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Ischemic stroke

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https://www.readbyqxmd.com/read/29029200/lateral-cerebellar-nucleus-stimulation-has-selective-effects-on-glutamatergic-and-gabaergic-perilesional-neurogenesis-after-cortical-ischemia-in-the-rodent-model
#1
Hugh H Chan, Jessica Cooperrider, Zhihong Chen, John T Gale, Kenneth B Baker, Connor A Wathen, Claire R Modic, Hyun-Joo Park, Andre G Machado
BACKGROUND: Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression of long-term potentiation markers in the perilesional cerebral cortex. OBJECTIVE: To further investigate the cellular changes associated with chronic LCN stimulation in the ischemic rodent by examining neurogenesis along the cerebellothalamocortical pathway...
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29027964/microglia-and-monocytes-macrophages-polarization-reveal-novel-therapeutic-mechanism-against-stroke
#2
REVIEW
Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohata
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types, ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival rate or improve the quality of life after ischemic and hemorrhagic stroke in the subacute to chronic phases. Therefore, it is necessary to establish therapeutic strategies to facilitate functional recovery in patients with stroke during both phases. Cell-based therapies, using microglia and monocytes/macrophages preconditioned by optimal stimuli and/or any therapies targeting these cells, might be an ideal therapeutic strategy for managing stroke...
October 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29027438/-meta-analysis-on-indirect-comparison-of-erigeron-breviscapus-injection-and-breviscapus-injection-in-treatment-of-acute-ischemic-stroke
#3
Yu-Fang Zhang, Xi-Tong Ke, Bao-Cai Li, Cheng Xiang, Song Zhao
Erigeron breviscapus injection(DZXI) and Breviscapus injection(DZSI) are two popular injections in treatment of acute ischemic stroke in China. Both of them are manufactured from a same herbal medicine, E. breviscapus, but DZXI is an herbal extract(mixture) preparation and DZSI is a pure compound injection. This article was aimed to systemically evaluate and compare their efficacy and safety in treatment of acute ischemic stroke. The randomized controlled trials(RCTs) were collected for comparing DZXI and DZSI with Salvia miltiorrhiza injection(FDI) as the medium, and they were compared with indirect Meta-analysis(ITC)...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027122/hi1a-as-a-novel-neuroprotective-agent-for-ischemic-stroke-by-inhibition-of-acid-sensing-ion-channel-1a
#4
Yandong Ren, Chengchong Li, Jinlong Chang, Rui Wang, Yuhua Wang, Xiang-Ping Chu
Strokes are the second-leading cause of death worldwide, and the cellular and molecular mechanisms underlying stroke-induced brain damage are still uncertain. The present therapy for acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen activator (rtPA). However, rtPA has a narrow therapeutic timeframe of 3-4.5 h, and only approximately 5% of stroke patients can benefit from rtPA treatment. Neuroprotective agents, such as N-methyl-D-aspartate receptor antagonists, have shown great promise in preclinical studies...
October 13, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29026741/salt-reduction-strategy-at-population-level
#5
Madhavi Bhargava
World is facing a huge burden of noncommunicable diseases such as hypertension, ischemic health diseases, and stroke. Moreover, the developing countries have had a relatively speedy rise of the problem, with noncommunicable diseases occurring at much lower age as compared to the developed world. The World Health Organization, therefore, recommends reduction in salt intake at population level to <5 g/day. Not all researchers and public health physicians agree to it, leading to conflicting information for a primary care physician...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026617/cerebral-vasculitis-and-intracranial-multiple-aneurysms-in-a-child-with-lyme-neuroborreliosis
#6
Elisa Kortela, Jukka Hytönen, Jussi Numminen, Margit Overmyer, Harri Saxen, Jarmo Oksi
Introduction. Lyme borreliosis is a multisystem tick-borne disease caused by Borrelia burgdorferi. Neurological manifestations are reported in up to 15 % of adult patients with Lyme disease, while the frequency among children is higher. The most common manifestations are painful radiculopathy, facial nerve paresis and lymphocytic meningitis. Epileptic seizures and cerebral vasculitis with stroke or aneurysms are very rare complications. Case presentation. We describe a paediatric patient with sensorineural auditory dysfunction, headache, fatigue and epileptic seizures as sequelae of meningoencephalitis/Lyme neuroborreliosis (LNB) caused by B...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29025926/enhancing-spinal-plasticity-amplifies-the-benefits-of-rehabilitative-training-and-improves-recovery-from-stroke
#7
Anna M Wiersma, Karim Fouad, Ian R Winship
The limited recovery that occurs following stroke happens almost entirely in the first weeks post injury. Moreover, the efficacy of rehabilitative training is limited beyond this narrow time frame. Sprouting of spared corticospinal tract axons in the contralesional spinal cord makes a significant contribution to sensorimotor recovery, but this structural plasticity is also limited to the first few weeks after stroke. Here, we tested the hypothesis that inducing plasticity in the spinal cord during chronic stroke could improve recovery from persistent sensorimotor impairment...
October 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29025728/necessary-catheter-diameters-for-mechanical-thrombectomy-with-adapt
#8
O Nikoubashman, A Nikoubashman, M Büsen, M Wiesmann
BACKGROUND AND PURPOSE: Large-bore catheters allow mechanical thrombectomy in ischemic stroke by engaging and retrieving clots without additional devices (direct aspiration first-pass technique [ADAPT]). The purpose of this study was to establish a model for minimal catheter diameters needed for ADAPT. MATERIALS AND METHODS: We established a theoretic model for the calculation of minimal catheter diameters needed for ADAPT. We then verified its validity in 28 ADAPT maneuvers in a porcine in vivo model...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29025724/correlation-between-clinical-outcomes-and-baseline-ct-and-ct-angiographic-findings-in-the-swift-prime-trial
#9
A P Jadhav, H-C Diener, A Bonafe, V M Pereira, E I Levy, B W Baxter, T G Jovin, R G Nogueira, D R Yavagal, C Cognard, D D Purcell, B K Menon, R Jahan, J L Saver, M Goyal
BACKGROUND AND PURPOSE: Patient selection for endovascular therapy remains a great challenge in clinic practice. We sought to determine the effect of baseline CT and angiography on outcomes in the Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial and to identify patients who would benefit from endovascular stroke therapy. MATERIALS AND METHODS: The primary end point was a 90-day modified Rankin Scale score of 0-2...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29024624/the-prognostic-impact-of-mild-hypokalemia-in-terms-of-death-and-stroke-in-the-general-population-a-prospective-population-study
#10
Nick Mattsson, Olav Wendelboe Nielsen, Linda Johnson, Eva Prescott, Peter Schnohr, Gorm Boje Jensen, Lars Køber, Ahmad Sajadieh
BACKGROUND: Potassium supplementation reduces the risk of cardiovascular mortality and stroke in population studies; however, the prognostic impact of mild hypokalemia in the general population has not been thoroughly investigated. We aimed to investigate associations between mild hypokalemia and endpoints in the general population. METHODS: participants (48-76 year old) from the general population study "Copenhagen City Heart Study" (n=5916) were studied. Participants were divided into groups according to baseline-values of plasma-potassium (potassium); Hypokalemia (<3...
October 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29024109/long-term-use-of-proton-pump-inhibitors-dose-response-relationship-and-associated-risk-of-ischemic-stroke-and-myocardial-infarction
#11
Thomas S G Sehested, Thomas A Gerds, Emil L Fosbøl, Peter W Hansen, Mette G Charlot, Nicholas Carlson, Mark A Hlatky, Christian Torp-Pedersen, Gunnar H Gislason
BACKGROUND: Use of proton pump inhibitors (PPIs) has been associated with cardiovascular disease among patients not on antiplatelet therapy. The associations of PPI use, duration and dose, with risk of first-time ischemic stroke and myocardial infarction (MI) are poorly understood. METHODS: All Danish individuals with no prior history of MI or stroke, who had an elective upper gastrointestinal endoscopy performed between 1997 and 2012, were identified from nationwide registries...
October 12, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29023958/stroke-induced-chronic-systolic-dysfunction-driven-by-sympathetic-overactivity
#12
Michael Bieber, Rudolf A Werner, Edit Tanai, Ulrich Hofmann, Takahiro Higuchi, Kai Schuh, Peter U Heuschmann, Stefan Frantz, Oliver Ritter, Peter Kraft, Christoph Kleinschnitz
OBJECTIVE: Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. While it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated cardiac enzymes and plasma catecholamines in the acute phase, nothing is known about the delayed consequences of ischemic stroke on cardiovascular function...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29023523/the-role-of-glutamate-in-neuronal-ion-homeostasis-a-case-study-of-spreading-depolarization
#13
Niklas Hübel, Mahshid S Hosseini-Zare, Jokūbas Žiburkus, Ghanim Ullah
Simultaneous changes in ion concentrations, glutamate, and cell volume together with exchange of matter between cell network and vasculature are ubiquitous in numerous brain pathologies. A complete understanding of pathological conditions as well as normal brain function, therefore, hinges on elucidating the molecular and cellular pathways involved in these mostly interdependent variations. In this paper, we develop the first computational framework that combines the Hodgkin-Huxley type spiking dynamics, dynamic ion concentrations and glutamate homeostasis, neuronal and astroglial volume changes, and ion exchange with vasculature into a comprehensive model to elucidate the role of glutamate uptake in the dynamics of spreading depolarization (SD)-the electrophysiological event underlying numerous pathologies including migraine, ischemic stroke, aneurysmal subarachnoid hemorrhage, intracerebral hematoma, and trauma...
October 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29023416/neuro-coagulopathy-blood-coagulation-factors-in-central-nervous-system-diseases
#14
REVIEW
Ciro De Luca, Assunta Virtuoso, Nicola Maggio, Michele Papa
Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central nervous system (CNS). The protease-activated receptors (PARs) pathway can be considered the central hub of this regulatory network, mainly through thrombin or activated protein C (aPC). These proteins, in fact, showed peculiar properties, being able to interfere with synaptic homeostasis other than coagulation itself. These specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix...
October 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29022854/single-center-mid-term-experience-with-chimney-graft-technique-for-the-preservation-of-flow-to-the-supra-aortic-branches
#15
Robert Shahverdyan, Spyridon Mylonas, Michael Gawenda, Jan Brunkwall
Objectives To investigate the feasibility and the mid-term outcomes of the chimney-graft technique for the revascularization of supra-aortic branches in patients with thoracic aortic pathologies involving the aortic arch. Methods A retrospective analysis of a prospectively maintained database between January 2010 and July 2016 was performed. Primary endpoints were 30-day and overall mortality. Secondary endpoints were technical success, target vessel patency, stroke/transitory ischemic attack and type I/III endoleak rate...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/29022745/real-world-adherence-to-oral-anticoagulant-in-non-valvular-atrial-fibrillation-patients-in-china
#16
Xiao Xiang, Yaying Cao, Kexin Sun, Jing Song, Yaohua Tian, Qiongzhou Yin, Juan Juan, Yonghua Hu
BACKGROUND AND OBJECTIVE: Adherence to oral anticoagulants is crucial for the prevention of ischemic stroke in atrial fibrillation patients; however, evidence of oral-anticoagulant adherence from developing countries is still lacking. Our study aimed to evaluate the current situation and predictors of oral-anticoagulant adherence in non-valvular atrial fibrillation (NVAF) patients in China. METHODS: Records of NVAF patients were obtained from a regional claims database...
October 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29022506/autologous-cell-therapy-for-vascular-regeneration-the-role-of-proangiogenic-cells
#17
Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani, Matteo Pirro
Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions. Both experimental and clinical studies indicate a therapeutic potential for different proangiogenic cells (PCs), including endothelial progenitor cells (EPCs) in the treatment of peripheral artery disease. A significant improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, contrasting results from different meta-analyses question the efficacy of PC-based approaches on long-term outcomes, including amputation and survival...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022132/an-exploratory-study-of-the-electronic-medical-record-and-outpatient-vascular-neurology-consultations
#18
Larissa Georgeon, Philip B Gorelick, Tenko Raykov, Muhammad U Farooq, Jiangyong Min, Christopher Goshgarian, Bradley Haveman-Gould, Amy Groenhout, Molly McCarthy
We carried out a quality improvement project utilizing the electronic medical record (EMR) to determine (1) the quality of vascular neurologists' recommendations for recurrent stroke prevention and (2) primary care provider (PCP) acknowledgement of the vascular neurologists' recurrent stroke prevention recommendations and their frequency of meeting the recommended metrics for risk factor control and lifestyle modification. We conducted a retrospective EMR chart review on a convenience sample of ischemic stroke patients during two epochs...
October 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29021986/integrated-treatment-modality-of-cathodal-transcranial-direct-current-stimulation-with-peripheral-sensory-stimulation-affords-neuroprotection-in-a-rat-stroke-model
#19
Yu-Hang Liu, Su Jing Chan, Han-Chi Pan, Aishwarya Bandla, Nicolas K K King, Peter Tsun Hon Wong, You-Yin Chen, Wai Hoe Ng, Nitish V Thakor, Lun-De Liao
Cathodal-transcranial direct current stimulation induces therapeutic effects in animal ischemia models by preventing the expansion of ischemic injury during the hyperacute phase of ischemia. However, its efficacy is limited by an accompanying decrease in cerebral blood flow. On the other hand, peripheral sensory stimulation can increase blood flow to specific brain areas resulting in rescue of neurovascular functions from ischemic damage. Therefore, the two modalities appear to complement each other to form an integrated treatment modality...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/29021776/sex-differences-in-rt-pa-utilization-at-hospitals-treating-stroke-the-national-inpatient-sample
#20
Amelia K Boehme, Brendan G Carr, Scott Eric Kasner, Karen C Albright, Michael J Kallan, Mitchell S V Elkind, Charles C Branas, Michael T Mullen
BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US. METHODS: Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs. RESULTS: There were 304,152 hospitalizations with a primary diagnosis of ischemic stroke between 2004 and 2010 in the analysis: 75,160 (24...
2017: Frontiers in Neurology
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