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Ischemic stroke

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https://www.readbyqxmd.com/read/29232701/differential-impact-of-white-matter-hyperintensities-on-long-term-outcomes-in-ischemic-stroke-patients-with-large-artery-atherosclerosis
#1
Minyoul Baik, Kyoungsub Kim, Joonsang Yoo, Hyeon Chang Kim, Seong Ho Jeong, Ki Hoon Kim, Hyung Jong Park, Young Dae Kim, Ji Hoe Heo, Hyo Suk Nam
BACKGROUND: The presence of white matter hyperintensity (WMH) is related to poor long-term outcomes in stroke patients. However, the long-term outcome is unknown in patients with both large artery atherosclerosis (LAA) and WMH. METHODS: We investigated the impact of WMH on long-term outcome in patients with LAA. Consecutive patients in a prospective stroke registry were included. Patients were followed for a median of 7.7 years (interquartile range, 5.6-9.7). The degree of WMH was assessed by Fazekas grade on fluid-attenuated inversion recovery images...
2017: PloS One
https://www.readbyqxmd.com/read/29232256/prognosis-comparisons-in-acute-ischemic-stroke-patients-with-thrombolysis-and-nonthrombolysis-therapy-a-retrospective-study-with-larger-sample-size
#2
Haojun Li, Yupeng Wu
: We compared the short-term, middle-term and long-term primary outcomes between thrombolysis and nonthrombolysis therapy in acute ischemic stroke (AIS) patients. Medical records were collected from patients suffered from AIS between 2010 and 2013 and allocated into either the intravenous recombinant tissue plasminogen activator (as rt-PA group) treatment, or non-rt-PA treatment group (as control group). The primary outcomes included a proportion of patients with favorable outcome [as defined with a modified Rankin Scale (mRS) of 0-1], functional independence (mRS of 0-2) or with bad outcome (mRS of 5-6) at 3, 6 and 12 months and the overall mortality...
December 11, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29231162/evaluation-of-clinical-outcomes-among-nonvalvular-atrial-fibrillation-patients-treated-with-rivaroxaban-or-warfarin-stratified-by-renal%C3%A2-function%C3%A2
#3
Matthew R Weir, Lloyd Haskell, Jeffrey S Berger, Veronica Ashton, François Laliberté, Concetta Crivera, Kip Brown, Patrick Lefebvre, Jeffrey Schein
BACKGROUND: Renal dysfunction increases the risk of thromboembolic and bleeding events in patients with nonvalvular atrial fibrillation (NVAF). MATERIALS AND METHODS: Adult NVAF patients with ≥ 6 months prior to first warfarin or rivaroxaban dispensing were selected from the IMS Health Real-World Data Adjudicated Claims database (05/2011 - 06/2015) with electronic medical records. Ischemic stroke events, thromboembolic events (venous thromboembolism, myocardial infarction, or ischemic stroke), and major bleeding events were compared between patients by renal function identified by 1) relevant ICD-9-CM diagnosis codes and 2) estimated creatinine clearance (eCrCl)...
December 12, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29230625/systemic-lupus-erythematosus-and-the-risk-of-perioperative-major-adverse-cardiovascular-events
#4
Nathaniel R Smilowitz, Gregory Katz, Jill P Buyon, Robert M Clancy, Jeffrey S Berger
Systemic lupus erythematosus (SLE) is a significant risk factor for cardiovascular disease. The relationship between SLE and perioperative cardiovascular risks following non-cardiac surgery is uncertain. We investigated associations between a diagnosis of SLE and outcomes following major non-cardiac surgery in a large national database from the United States. Patients age ≥ 18 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data from 2004 to 2014...
December 11, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29230011/pairing-sound-with-vagus-nerve-stimulation-modulates-cortical-synchrony-and-phase-coherence-in-tinnitus-an-exploratory-retrospective-study
#5
Sven Vanneste, Jeffrey Martin, Robert L Rennaker, Michael P Kilgard
Recent research has shown that vagus nerve stimulation (VNS) paired with tones or with rehabilitative training can help patients to achieve reductions in tinnitus perception or to expedite motor rehabilitation after suffering an ischemic stroke. The rationale behind this treatment is that VNS paired with experience can drive neural plasticity in a controlled and therapeutic direction. Since previous studies observed that gamma activity in the auditory cortex is correlated with tinnitus loudness, we assessed resting-state source-localized EEG before and after one to three months of VNS-tone pairing in chronic tinnitus patients...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229726/prognostic-significance-of-blood-pressure-variability-on-beat-to-beat-monitoring-after-transient-ischemic-attack-and-stroke
#6
Alastair J S Webb, Sara Mazzucco, Linxin Li, Peter M Rothwell
BACKGROUND AND PURPOSE: Visit-to-visit and day-to-day blood pressure (BP) variability (BPV) predict an increased risk of cardiovascular events but only reflect 1 form of BPV. Beat-to-beat BPV can be rapidly assessed and might also be predictive. METHODS: In consecutive patients within 6 weeks of transient ischemic attack or nondisabling stroke (Oxford Vascular Study), BPV (coefficient of variation) was measured beat-to-beat for 5 minutes (Finometer), day-to-day for 1 week on home monitoring (3 readings, 3× daily), and on awake ambulatory BP monitoring...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29229724/serum-galectin-3-and-poor-outcomes-among-patients-with-acute-ischemic-stroke
#7
Aili Wang, Chongke Zhong, Zhengbao Zhu, Tian Xu, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Jianhui Zhang, Xiaodong Yuan, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND PURPOSE: Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke. METHODS: Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, ≥3) at 3 months after stroke...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29229723/prospective-study-of-fasting-blood-glucose-and-intracerebral-hemorrhagic-risk
#8
Cheng Jin, Guohong Li, Kathryn M Rexrode, Mahmut E Gurol, Xiaodong Yuan, Ying Hui, Chunyu Ruan, Anand Vaidya, Yanxiu Wang, Shouling Wu, Xiang Gao
BACKGROUND AND PURPOSE: Although diabetes mellitus is an established independent risk factor for ischemic stroke, the association between fasting blood glucose and intracerebral hemorrhage (ICH) is limited and inconsistent. The objective of the current study was to examine the potential impact of long-term fasting blood glucose concentration on subsequent risk of ICH. METHODS: This prospective study included 96 110 participants of the Kailuan study, living in Kailuan community, Tangshan city, China, who were free of cardiovascular diseases and cancer at baseline (2006)...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29229619/optimizing-systems-of-care-for-endovascular-thrombectomy-in-ischemic-stroke-drip-and-ship-versus-mothership
#9
EDITORIAL
Bruce C V Campbell, Geoffrey A Donnan, Stephen M Davis
No abstract text is available yet for this article.
December 12, 2017: Circulation
https://www.readbyqxmd.com/read/29229471/patent-foramen-ovale-closure-for-secondary-prevention-of-cryptogenic-stroke-updated-meta-analysis-of-randomized-clinical-trials
#10
Muthiah Vaduganathan, Arman Qamar, Ankur Gupta, Navkaranbir Bajaj, Harsh B Golwala, Ambarish Pandey, Deepak L Bhatt
BACKGROUND: Patent foramen ovale closure represents a potential secondary prevention strategy for cryptogenic stroke, but available trials have varied by size, device studied, and follow-up. METHODS: We conducted a systematic search of published randomized clinical trials (RCTs) evaluating patent foramen ovale closure vs. medical therapy in patients with recent stroke or transient ischemic attack using PubMED, EMBASE, and Cochrane through September 2017. Weighting was by random effects models...
December 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29229232/dyslipidemia-in-children-with-arterial-ischemic-stroke-prevalence-and-risk-factors
#11
Sally Sultan, Michael Dowling, Adam Kirton, Gabrielle DeVeber, Alexandra Linds, Mitchell S V Elkind
BACKGROUND: Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. METHODS: We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values...
October 10, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29228661/interactions-between-acyp2-genetic-polymorphisms-and-environment-factors-with-susceptibility-to-ischemic-stroke-in-a-han-chinese-population
#12
Qiong Cheng, Yong-Kun Li, Feng Lu, Lianhua Yin, Yin-Zhou Wang, Wen Wei, Qian Lin
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within ACYP2 gene and additional gene- environment interaction with ischemic stroke (IS) risk in a Chinese population. Results: IS risk was significantly higher in carriers with the G allele of rs11896604 than those with CC genotype (CG or GG versus CC), adjusted OR (95%CI) =1.60 (1.18-2.20), and higher in carriers with the A allele of rs12615793 than those with GG genotype (GA or AA versus GG), adjusted OR (95%CI) = 1...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228630/transplantation-of-ips-cell-derived-neural-progenitors-overexpressing-sdf-1%C3%AE-increases-regeneration-and-functional-recovery-after-ischemic-stroke
#13
Monica Chau, Todd C Deveau, Mingke Song, Zheng Z Wei, Xiaohuan Gu, Shan Ping Yu, Ling Wei
Ischemic stroke is a leading cause of human death and disability while clinical treatments are limited. The adult brain possesses endogenous regenerative activities that may benefit tissue repair after stroke. Trophic factors such as stromal cell-derived factor 1 alpha (SDF-1α) are upregulated in the ischemic brain, which promote endogenous regeneration. The regenerative response, however, is normally insufficient. Transplantation of exogenous cells has been explored as regenerative therapies. One promising cell type for transplantation is induced pluripotent stem (iPS) cells which are cells genetically reprogrammed from adult somatic cells...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228591/up-regulation-of-angiotensin-converting-enzyme-in-response-to-acute-ischemic-stroke-via-erk-nf-%C3%AE%C2%BAb-pathway-in-spontaneously-hypertensive-rats
#14
Zhou Ou, Meng-Xing Tao, Qing Gao, Xue-Ling Zhang, Yang Yang, Jun-Shan Zhou, Ying-Dong Zhang
Cerebral ischemic stroke is usually caused by a temporary or permanent decrease in blood supply to the brain. Despite general progress in diagnosis and treatment, the prognosis of stroke is still unsatisfactory, and more detailed potential mechanisms are needed to investigate underlying the pathological process. Here, we showed that serum angiotensin-converting enzyme (ACE) concentration was positively correlated with infarct volume after acute ischemic stroke (AIS). Moreover, using a permanent middle cerebral artery occlusion rat model, we indicated for the first time that increased ACE expression in response to AIS was regulated by the ERK/NF-κB pathway in peri-infarct regions...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228037/potential-serum-biomarkers-and-metabonomic-profiling-of-serum-in-ischemic-stroke-patients-using-uplc-q-tof-ms-ms
#15
Hongxue Sun, Jiaying Zhao, Di Zhong, Guozhong Li
BACKGROUND: Stroke still has a high incidence with a tremendous public health burden and it is a leading cause of mortality and disability. However, biomarkers for early diagnosis are absent and the metabolic alterations associated with ischemic stroke are not clearly understood. The objectives of this case-control study are to identify serum biomarkers and explore the metabolic alterations of ischemic stroke. METHODS: Metabonomic analysis was performed using ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry and multivariate statistical analysis was employed to study 60 patients with or without ischemic stroke (30 cases and 30 controls)...
2017: PloS One
https://www.readbyqxmd.com/read/29227292/association-of-hyperglycemia-systolic-and-diastolic-hypertension-and-hyperthermia-relative-to-baseline-in-the-acute-phase-of-stroke-with-poor-outcome-after-intravenous-thrombolysis
#16
Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Paolo Bovi, Manuel Cappellari
: In the acute phase of ischemic stroke, the trend of some physiological variables, such as blood glucose (BG), blood pressure, and body temperature (BT), might influence outcome. We aimed to assess the association of hyperglycemia, systolic and diastolic hypertension, and hyperthermia relative to baseline BG, systolic blood pressure, diastolic blood pressure and BT, respectively, in the first 12 h with poor outcome after intravenous thrombolysis (IVT). We conducted a retrospective analysis of data prospectively collected from 200 consecutive anterior ischemic stroke patients treated with IVT...
December 8, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29227260/factors-associated-with-post-stroke-fatigue-during-the-second-half-year-after-stroke
#17
M Delva, N Lytvynenko, I Delva
Post-stroke fatigue (PSF) is a common and often debilitating sequel of both ischemic and hemorrhagic strokes Aim - identify socio-demographic, personal and psychological factors associated with different PSF domains over the second half year after stroke occurrence. There were examined patients consequently in definite time points: at 6 months (156 patients), at 9 months (139 patients) and at 12 months (128 patients) after ischemic or hemorrhagic strokes. Global PSF and certain PSF domains (physical, mental, motivational, activity-related) were measured by multidimensional fatigue inventory-20 scale...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29227258/-causes-of-lethality-of-ischemic-stroke-and-ways-to-improve-prevention-methods
#18
Y Uteuliyev, K Konysbayeva, L Tekebaeva, B Alibekov, G Tokmurziyeva
In this article, the authors conduct an in-depth analysis of the causes of mortality from ischemic stroke in Almaty city of the Republic of Kazakhstan. Based on the materials of the city pathoanatomical bureau for 2015, 2016, and nine months of 2017. Autopsy materials and results of histological examination were analyzed. The materials of the study were processed using the methods of applied biostatistics. According to the results of the study, the authors came to the conclusion that the greatest number of patients who died of this pathology is in men aged 51 and older than 80 years, and in women 61 and older...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29225622/correlation-between-ch2ds2-vasc-score-and-serum-leptin-levels-in-cardioembolic-stroke-patients-the-impact-of-metabolic-syndrome
#19
Anna Szczepańska-Szerej, Jacek Kurzepa, Aneta Grabarska, Joanna Bielewicz, Ewa Wlizło-Dyś, Konrad Rejdak
Objective: To determine adipokines levels in patients with different etiologic subtypes of acute ischemic stroke (AIS) and metabolic syndrome (MetS) status. Methods: Serum adiponectin, leptin, and resistin levels were determined by ELISA in 99 AIS patients and 59 stroke-free control group subjects. Stroke patients were grouped based on MetS, modified TOAST classification, and CHA2DS2-VASc scale in case of cardioembolic stroke following atrial fibrillation. Results: No differences were found in all adipokine serum levels between AIS patients and appropriately matched control group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29225325/omentin-1-is-associated-with-carotid-plaque-instability-among-ischemic-stroke-patients
#20
Tian Xu, Peng Zuo, Lin Cao, Zhiwei Gao, Kaifu Ke
AIMS: Omentin-1 was proved to be associated with ischemic stroke clinical functional outcome. It also predicted carotid atherosclerosis among metabolic syndrome subjects and type 2 diabetes patients. Our aim was to examine the association of omentin-1 levels with carotid plaque instability and stenosis degree among ischemic stroke patients. METHODS: A total of 173 acute ischemic stroke patients were included in this study. Serum omentin-1 levels were assayed. Carotid ultrasound examinations were performed to evaluate the carotid plaque instability and stenosis degree...
December 9, 2017: Journal of Atherosclerosis and Thrombosis
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