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https://www.readbyqxmd.com/read/29328498/an-uplc-ms-ms-method-for-simultaneous-determination-of-five-flavonoids-from-stellerachamaejasme-l-in-rat-plasma-and-its-application-to-a-pharmacokinetic-study
#1
Yun-Qing Li, Cheng-Jian Li, Lei Lv, Qing-Qing Cao, Xian Qian, Si Wei Li, Hui Wang, Liang Zhao
Stellerachamaejasme L. has been used as a Traditional Chinese Medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis. A sensitive and selective ultra-high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous determination of five flavonoids (stelleranol, chamaechromone, neochamaejasmin A, chamaejasmine and isochamaejasmin) of Stellerachamaejasme L. in rat plasma. Chromatographic separation was accomplished on an Agilent Poroshell 120 EC-C18 column (2...
January 12, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29318996/a-case-report-of-real-time-in-vivo-demonstration-of-sarcoptes-scabiei
#2
Mehmet Salih Gürel, Aslı Vefa Turgut Erdemir, Burak Tekin
Scabies is a pruritic dermatosis caused by the ectoparasite Sarcoptes scabiei var. hominis. The diagnosis of scabies is usually made on clinical grounds, but histopathological and/or dermoscopic examinations may sometimes be of assistance. However, these diagnostic modalities do not offer a detailed in vivo demonstration of the motile microorganism. Reflectance confocal microscopy (RCM) is a relatively novel imaging modality that permits in vivo examination of the skin at a resolution similar to that used during similar to histopathologic resolution...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29316196/genetic-background-affects-pathogenicity-island-function-and-pathogen-emergence-in-streptomyces
#3
Yucheng Zhang, Guangde Jiang, Yousong Ding, Rosemary Loria
With few exceptions, thaxtomin A (ThxA), a nitrated diketopiperazine, is the pathogenicity determinant for plant pathogenic Streptomyces species. In Streptomyces scabiei (syn. S. scabies), the ThxA biosynthetic cluster is located within a 177 Kb mobile pathogenicity island, called the toxicogenic region (TR). In S. turgidiscabies, the ThxA biosynthetic cluster is located within a 674 Kb pathogenicity island (PAIst). Emergence of new plant pathogens occurs in this genus, but not frequently. This raises the question of whether mobilization of these pathogenicity regions, through mating, is widespread and whether TR and PAIst can confer plant pathogenicity...
January 9, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29307013/the-coronafacoyl-phytotoxins-structure-biosynthesis-regulation-and-biological-activities
#4
Dawn R D Bignell, Zhenlong Cheng, Luke Bown
Phytotoxins are secondary metabolites that contribute to the development and/or severity of diseases caused by various plant pathogenic microorganisms. The coronafacoyl phytotoxins are an important family of plant toxins that are known or suspected to be produced by several phylogenetically distinct plant pathogenic bacteria, including the gammaproteobacterium Pseudomonas syringae and the actinobacterium Streptomyces scabies. At least seven different family members have been identified, of which coronatine was the first to be described and is the best-characterized...
January 6, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29279260/scabies-crusted-norwegian-scabies-and-the-diagnosis-of-mite-sensitisation
#5
REVIEW
M Sánchez-Borges, L González-Aveledo, A Capriles-Hulett, F Caballero-Fonseca
Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE class antibodies to Sarcoptes scabiei allergens which cross-react with Dermatophagoides major allergens Der p 1 and Der p 2, positive immediate-type skin tests to house dust mite extracts should be interpreted cautiously...
December 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29241784/ivermectin-versus-permethrin-in-the-treatment-of-scabies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Ashar Dhana, Hsi Yen, Jean-Phillip Okhovat, Eunyoung Cho, NaNa Keum, Nonhlanhla P Khumalo
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29232427/what-s-eating-you-scabies-in-the-developing-world
#7
Fernanda Salgado, Dirk M Elston
Scabies infestation is a major cause of impetigo and subsequent renal failure in the developing world, and efforts to eradicate widespread infestation are underway. Ivermectin, topical sulfur, and topical benzyl benzoate often are used to treat widespread outbreaks.
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29208876/disease-pattern-among-children-attending-pediatric-outpatient-department-in-community-based-medical-college-hospital-bangladesh
#8
M Begum, M K Khan, M T Hossain, M Y Ali, F S Alam, S S Dipu, A H Hasan, M Nasrin
Disease pattern is based on socio-demographic characteristics, comprehensive health care services, and environmental variables like water supply, basic sanitation and housing, illness behavior like quick decision to arrive at health care facility, and treatment behavior like the modality of treatment they receive. The descriptive cross-sectional study was conducted during the period of January 2014 to December 2015. The study was carried out among 310 purposively selected children attended at Pediatric Outpatient department of Community Based Medical College Hospital, Bangladesh...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208763/characterization-of-the-catalytic-signature-of-scabin-toxin-a-dna-targeting-adp-ribosyltransferase
#9
Bronwyn Lyons, Miguel R Lugo, Stephanie Carlin, Taylor Lidster, A Rod Merrill
Scabin was previously identified as a novel DNA-targeting mono-ADP-ribosyltransferase toxin from the plant pathogen 87.22 strain of Streptomyces scabies Scabin is a member of the Pierisin-like subgroup of mono-ADP-ribosyltransferase toxins, since it targets DNA. An in-depth characterization of both the glycohydrolase and transferase enzymatic activities of Scabin was conducted. Several protein variants were developed based on an initial Scabin·DNA molecular model. Consequently, three residues were deemed important for DNA binding and transferase activity...
December 5, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29199154/leukocytoclastic-vasculitis-associated-with-crusted-scabies
#10
Katsuhiko Nishihara, Ken Shiraishi, Koji Sayama
No abstract text is available yet for this article.
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29198783/common-child-and-adolescent-cutaneous-infestations-and-fungal-infections
#11
Sherman J Alter, Megan B McDonald, Julie Schloemer, Ryan Simon, Julian Trevino
Cutaneous infections and infestations are common among children and adolescents. Ectoparasitic infestations affect individuals across the globe. Head lice, body lice, scabies, and infestations with bed bugs are seen in individuals who reside in both resource poor areas and in developed countries. Superficial cutaneous and mucosal candida occur throughput the life cycle. Dermatophyte infections of keratin-containing skin and skin structures result in tinea capitis (scalp), tinea corporis (body), tinea pedis (foot), and tinea unguium (nails)...
November 30, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29190667/hospital-admissions-for-skin-infections-among-western-australian-children-and-adolescents-from-1996-to-2012
#12
Tasnim Abdalla, David Hendrickx, Parveen Fathima, Roz Walker, Christopher C Blyth, Jonathan R Carapetis, Asha C Bowen, Hannah C Moore
The objective of this study was to describe the occurrence of skin infection associated hospitalizations in children born in Western Australia (WA). We conducted a retrospective cohort study of all children born in WA between 1996 and 2012 (n = 469,589). Of these, 31,348 (6.7%) were Aboriginal and 240,237 (51.2%) were boys. We report the annual age-specific hospital admission rates by geographical location and diagnostic category. We applied log-linear regression modelling to analyse changes in temporal trends of hospitalizations...
2017: PloS One
https://www.readbyqxmd.com/read/29190303/scabies-in-the-age-of-increasing-drug-resistance
#13
REVIEW
Samar Khalil, Ossama Abbas, Abdul Ghani Kibbi, Mazen Kurban
Scabies is an infestation of the skin by the mite Sarcoptes scabiei. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. This paper will review the mechanisms of resistance proposed in the literature and some of the potential solutions to this problem.
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29186253/crusted-scabies-due-to-indiscriminate-use-of-glucocorticoid-therapy-in-infant
#14
Fernanda Carvalho da Rocha Lima, Ana Maria Mósca Cerqueira, Manuela Boleira Sieiro Guimarães, Carolina Barbosa de Sousa Padilha, Fernanda Helena Craide, Marina Bombardelli
Crusted or Norwegian scabies is a parasitic infectious disease caused by Sarcoptes scabiei var. hominis that mainly affects immunocompromised individuals and those with neurological patients. We report a case of crusted scabies in a 4-month-old infant who had been treated erroneously for atopic dermatitis with high doses of corticosteroids. This initial misdiagnosis associated with the abusive use of corticosteroid facilitated the evolution of scabies to crusted scabies and its main complications of secondary infection and sepsis...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29183283/mitochondrial-genome-sequencing-reveals-potential-origins-of-the-scabies-mite-sarcoptes-scabiei-infesting-two-iconic-australian-marsupials
#15
Tamieka A Fraser, Renfu Shao, Nicholas M Fountain-Jones, Michael Charleston, Alynn Martin, Pam Whiteley, Roz Holme, Scott Carver, Adam Polkinghorne
BACKGROUND: Debilitating skin infestations caused by the mite, Sarcoptes scabiei, have a profound impact on human and animal health globally. In Australia, this impact is evident across different segments of Australian society, with a growing recognition that it can contribute to rapid declines of native Australian marsupials. Cross-host transmission has been suggested to play a significant role in the epidemiology and origin of mite infestations in different species but a chronic lack of genetic resources has made further inferences difficult...
November 28, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29137399/molecular-characteristics-and-serodiagnostic-potential-of-chitinase-like-protein-from-sarcoptes-scabiei
#16
Ran He, Nengxing Shen, Haojie Zhang, Yongjun Ren, Manli He, Jing Xu, Cheng Guo, Yue Xie, Xiaobin Gu, Weimin Lai, Xuerong Peng, Guangyou Yang
Scabies, caused by the mite Sarcoptes scabiei, is an allergic skin disease that affects millions of people and other mammals worldwide. This highly contagious parasitic disease is among the top 50 epidemic disease and is regarded as a neglected tropical disease. Diagnosis of scabies is difficult in the early stage, and the pathogenesis of scabies is not currently clear. Here, we expressed, identified and located the chitinase-like protein of S. scabiei (SsCLP), and evaluated its potential as an early-stage diagnostic antigen for rabbit scabies...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128241/-diagnosis-and-treatment-of-scabies-by-general-practitioners-a-survey-of-practices-in-france
#17
A R Schmidt-Guerre, B Aranda-Hulin, M Maumy-Bertrand, F Aubin
BACKGROUND: Although there is evidence suggesting an epidemiologic increase of scabies in France, few studies have assessed medical practice in terms of diagnosis and treatment. OBJECTIVES: To describe the management of scabies by general practitioners (GPs). PATIENTS AND METHODS: A questionnaire was addressed to the 524 GPs of the Doubs department in France regarding the management of cases of scabies diagnosed between January and June 2015...
November 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29113603/identification-of-a-novel-pyp-1-gene-in-sarcoptes-scabiei-and-its-potential-as-a-serodiagnostic-candidate-by-indirect-elisa
#18
Jing Xu, Xing Huang, Manli He, Yongjun Ren, Nengxing Shen, Chunyan Li, Ran He, Yue Xie, Xiaobin Gu, Bo Jing, Xuerong Peng, Guangyou Yang
Scabies is a parasitic disease caused by the ectoparasite Sarcoptes scabiei, affecting different mammalian species, including rabbits, worldwide. In the present study, we cloned and expressed a novel inorganic pyrophosphatase, Ssc-PYP-1, from S. scabiei var. cuniculi. Immunofluorescence staining showed that native Ssc-PYP-1 was localized in the tegument around the mouthparts and the entire legs, as well as in the cuticle of the mites. Interestingly, obvious staining was also observed on the fecal pellets of mites and in the integument of the mites...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29090458/a-narrative-review-of-dermatologic-protocols-for-primary-care-medical-service-trips-in-latin-america-and-the-caribbean
#19
Christopher Dainton, Charlene H Chu
BACKGROUND: Skin disorders are prevalent on primary care medical service trips in Latin America and the Caribbean and commonly include scabies, superficial mycoses, and pyoderma. There have been no previous attempts to describe protocols that international volunteer clinicians use in managing these patients. The purpose of this study was to collect North American clinical protocols used by sending organizations in their volunteer operations in Latin America and the Caribbean, summarize the most common pharmacologic and nonpharmacologic management strategies, and compare these to published international practice recommendations...
October 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29077242/contribution-of-the-%C3%AE-glucosidase-bglc-to-the-onset-of-the-pathogenic-lifestyle-of-streptomyces-scabies
#20
Samuel Jourdan, Isolde M Francis, Benoit Deflandre, Elodie Tenconi, Jennifer Riley, Sören Planckaert, Pierre Tocquin, Loïc Martinet, Bart Devreese, Rosemary Loria, Sébastien Rigali
Common scab disease on root and tuber plants is caused by Streptomyces scabies and related species which use the cellulose synthase inhibitor thaxtomin A as the main phytotoxin. Thaxtomin production is primarily triggered by the import of cello-oligosaccharides. Once inside the cell, the fate of the cello-oligosaccharides is dichotomized into i) fueling glycolysis with glucose for the saprophytic lifestyle through the action of β-glucosidase(s) (BG), and ii) eliciting the pathogenic lifestyle by inhibiting the CebR-mediated transcriptional repression of thaxtomin biosynthetic genes...
October 27, 2017: Molecular Plant Pathology
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