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https://www.readbyqxmd.com/read/29771976/skin-disease-prevalence-study-in-schoolchildren-in-rural-c%C3%A3-te-d-ivoire-implications-for-integration-of-neglected-skin-diseases-skin-ntds
#1
Rie Roselyne Yotsu, Kouamé Kouadio, Bamba Vagamon, Konan N'guessan, Amari Jules Akpa, Aubin Yao, Julien Aké, Rigobert Abbet Abbet, Barbine Tchamba Agbor Agbor, Roger Bedimo, Norihisa Ishii, L Claire Fuller, Roderick Hay, Oriol Mitjà, Henning Drechsler, Kingsley Asiedu
BACKGROUND: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process. METHODS: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa...
May 17, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29771941/efficacy-of-ivermectin-mass-drug-administration-to-control-scabies-in-asylum-seekers-in-the-netherlands-a-retrospective-cohort-study-between-january-2014-march-2016
#2
Dorien T Beeres, Sofanne J Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D Wijnholds, Jessica J H Hendriks, Johanneke Kleinnijenhuis, Till F Omansen, Ymkje Stienstra
Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was introduced in the main national reception centre based on frequent observations of scabies and its complications amongst Eritrean and Ethiopian asylum seekers in the Netherlands...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29769145/phylogenetic-relationships-stage-specific-expression-and-localisation-of-a-unique-family-of-inactive-cysteine-proteases-in-sarcoptes-scabiei
#3
Deepani D Fernando, Simone L Reynolds, Martha Zakrzewski, Ehtesham Mofiz, Anthony T Papenfuss, Deborah Holt, Katja Fischer
BACKGROUND: Scabies is worldwide one of the most common, yet neglected, parasitic skin infections, affecting a wide range of mammals including humans. Limited treatment options and evidence of emerging mite resistance against the currently used drugs drive our research to explore new therapeutic candidates. Previously, we discovered a multicopy family of genes encoding cysteine proteases with their catalytic sites inactivated by mutation (SMIPP-Cs). This protein family is unique in parasitic scabies mites and is absent in related non-burrowing mites...
May 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29769017/a-cross-sectional-investigation-of-the-health-needs-of-asylum-seekers-in-a-refugee-clinic-in-germany
#4
Laura F Goodman, Guy W Jensen, Joseph M Galante, Diana L Farmer, Stephanie Taché
BACKGROUND: Over one million asylum seekers were registered in Germany in 2016, most from Syria and Afghanistan. The Refugee Convention guarantees access to healthcare, however delivery mechanisms remain heterogeneous. There is an urgent need for more data describing the health conditions of asylum seekers to guide best practices for healthcare delivery. In this study, we describe the state of health of asylum seekers presenting to a multi-specialty primary care refugee clinic. METHODS: Demographic and medical diagnosis data were extracted from the electronic medical records of patients seen at the ambulatory refugee clinic in Dresden, Germany between 15 September 2015 and 31 December 2016...
May 16, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29734959/calculation-of-the-age-of-the-first-infection-for-skin-sores-and-scabies-in-five-remote-communities-in-northern-australia
#5
M J Lydeamore, P T Campbell, W Cuningham, R M Andrews, T Kearns, D Clucas, R Gundjirryirr Dhurrkay, J Carapetis, S Y C Tong, J M McCaw, J McVernon
Prevalence of skin sores and scabies in remote Australian Aboriginal communities remains unacceptably high, with Group A Streptococcus (GAS) the dominant pathogen. We aim to better understand the drivers of GAS transmission using mathematical models. To estimate the force of infection, we quantified the age of first skin sores and scabies infection by pooling historical data from three studies conducted across five remote Aboriginal communities for children born between 2001 and 2005. We estimated the age of the first infection using the Kaplan-Meier estimator; parametric exponential mixture model; and Cox proportional hazards...
May 8, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29723368/atypical-crusted-scabies-in-a-patient-with-chronic-liver-disease-caused-by-hepatitis-b-and-d-viruses
#6
Mônica Santos, Gustavo Ávila Maquiné, Carolina Talhari, Antonio Pedro Mendes Schettini
Crusted scabies is a less common variant of scabies that is highly contagious, difficult to treat and involves infestation by Sarcoptes scabiei var. hominis. The classical clinical presentation includes crusted, scaly and generally non-pruritic lesions usually located on the head, neck, palmar, plantar and periungual region. It was first described in Norway in 1848 in patients with leprosy who presented with crusted lesions. In this study, we report the case of a patient with crusted scabies with florid clinical manifestations and chronic liver disease due to hepatitis B and delta virus infection...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29702253/infectious-disease-profiles-of-syrian-and-eritrean-migrants-presenting-in-europe-a-systematic-review
#7
Egon Isenring, Jan Fehr, Nejla Gültekin, Patricia Schlagenhauf
BACKGROUND: In the past decade, a large influx of migrants presented in Europe. Their country of origin was mainly either Syria or Eritrea. Public health institutions in host countries in Europe are challenged to screen and care for migrant populations with regard to infectious diseases. METHODS: We performed a systematic literature review (according to PRISMA guidelines) to define the infectious disease profile of migrants originating in Syria and Eritrea. RESULTS: The search resulted in 825 papers of possible relevance for infectious diseases in migrants from Syria, of which, after screening, we included 35 in the systematic review...
April 24, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29698535/biological-control-of-potato-common-scab-by-bacillus-amyloliquefaciens-ba01
#8
Chih Lin, Chia-Hsin Tsai, Pi-Yu Chen, Chia-Yen Wu, Ya-Lin Chang, Yu-Liang Yang, Ying-Lien Chen
Potato common scab, which is caused by soil-borne Streptomyces species, is a severe plant disease that results in a significant reduction in the economic value of potatoes worldwide. Due to the lack of efficacious pesticides, crop rotations, and resistant potato cultivars against the disease, we investigated whether biological control can serve as an alternative approach. In this study, multiple Bacillus species were isolated from healthy potato tubers, and Bacillus amyloliquefaciens Ba01 was chosen for further analyses based on its potency against the potato common scab pathogen Streptomyces scabies...
2018: PloS One
https://www.readbyqxmd.com/read/29692685/itraq-based-quantitative-proteomic-analysis-of-processed-euphorbia-lathyris-l-for-reducing-the-intestinal-toxicity
#9
Yu Zhang, Yingzi Wang, Shaojing Li, Xiuting Zhang, Wenhua Li, Shengxiu Luo, Zhenyang Sun, Ruijie Nie
Background: Euphorbia lathyris L., a Traditional Chinese medicine (TCM), is commonly used for the treatment of hydropsy, ascites, constipation, amenorrhea, and scabies. Semen Euphorbiae Pulveratum, which is another type of Euphorbia lathyris that is commonly used in TCM practice and is obtained by removing the oil from the seed that is called paozhi, has been known to ease diarrhea. Whereas, the mechanisms of reducing intestinal toxicity have not been clearly investigated yet. Methods: In this study, the isobaric tags for relative and absolute quantitation (iTRAQ) in combination with the liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic method was applied to investigate the effects of Euphorbia lathyris L...
2018: Proteome Science
https://www.readbyqxmd.com/read/29667798/delusional-infestation-in-psychodermatology
#10
Monica Rosales Santillan, Dustin L Taylor, Jason S Reichenberg
Delusional infestation (DI), also known as delusional parasitosis, consists of a patient's strong belief that he or she is infested with a nonliving substance or living organism despite lack of medical evidence to support this belief. The most commonly reported sources of infestation include insects, fibrous strands, worms, and scabies. Delusional infestation is predominantly seen in women and older patients. This disorder has a variable course and prognosis in patients. Delusional infestation can be a primary psychiatric problem, or secondary to underlying medical conditions or other psychiatric disorders...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667664/identification-of-a-novel-aminopolycarboxylic-acid-siderophore-gene-cluster-encoding-the-biosynthesis-of-ethylenediaminesuccinic-acid-hydroxyarginine-edha
#11
Marius Spohn, Simone Edenhart, Mohammad Alanjary, Nadine Ziemert, Daniel Wibberg, Jörn Kalinowski, Timo H J Niedermeyer, Evi Stegmann, Wolfgang Wohlleben
The mechanism of siderophore-mediated iron supply enhances fitness and survivability of microorganisms under iron limited growth conditions. One class of naturally occurring ionophores is the small aminopolycarboxylic acids (APCAs). Although they are structurally related to the most famous anthropogenic chelating agent, ethylenediaminetetraacetate (EDTA), they have been largely neglected by the scientific community. Here, we demonstrate the detection of APCA gene clusters by a computational screening of a nucleotide database...
April 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29663338/tackling-scabies-novel-agents-for-a-neglected-disease
#12
REVIEW
Hima Gopinath, Manju Aishwarya, Kaliaperumal Karthikeyan
The scabies mite, Sarcoptes scabiei var hominis, is an obligate ectoparasite of humans. It has been a source of distress for humanity since antiquity. The troublesome mite is emerging triumphant over current acaricidal agents with reports of emerging resistance and treatment failures. Scabies in endemic areas and crusted scabies offer additional management challenges. Exploration of indigenous plants and better understanding of mite biology and pathogenesis provide opportunities for the development of novel agents for this common pest...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29653437/early-infectious-exposures-are-not-associated-with-increased-risk-of-pediatric-onset-multiple-sclerosis
#13
Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves
OBJECTIVE: We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS: This was a case-control study of children with MS or clinically isolated syndrome (CIS) and healthy controls enrolled at sixteen clinics participating in the US Network of Pediatric MS Centers. Parents completed a comprehensive environmental questionnaire that captured early infectious exposures, habits, and illnesses in the first five years of life...
March 26, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29624634/the-efficacy-of-a-nested-pcr-in-detecting-cytochrome-c-oxidase-subunit-1-gene-of-sarcoptes-scabiei-var-hominis-for-diagnosing-scabies
#14
J E Hahm, C W Kim, S S Kim
BACKGROUND: A widespread scabies infestation, associated to long-term residence in nursing homes, is becoming a serious issue in developed countries. Mineral oil examination is regarded as the gold standard in diagnosing scabies, but the sensitivity of this method is generally low-approximately 50%. Molecular tests may contribute to enhance the sensitivity of current tests for laboratory diagnosis of human scabies. OBJECTIVES: In this study, we developed new primers for a nested PCR for the cytochrome c oxidase subunit 1 (cox1) gene of Sarcoptes scabiei var...
April 6, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29619436/concomitant-sexually-transmitted-diseases-in-patients-with-diagnosed-hiv-aids-a-retrospective-study
#15
Densy Violina Harnanti, Afif Nurul Hidayati, Muhammad Miftahussurur
Background: Human immunodeficiency virus (HIV) is a virus that causes Acquired Immunodeficiency Syndrome (AIDS) which weaken the human immune system and thus increasing the incidence of sexually transmitted infections (STIs) and vice versa. Materials and Methods: A retrospective study of STIs in HIV/AIDS patients in Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) Dr. Soetomo General Hospital Surabaya was conducted from January 1st, 2013 to December 31st, 2014...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29611610/prevalence-of-skin-diseases-amongst-moroccan-fishermen
#16
Omar Laraqui, Nadia Manar, Salwa Laraqui, Tarik Ghailan, Frédéric Deschamps, Reda Hammouda, Chakib El Houssine Laraqui
BACKGROUND: The main objective was to evaluate the prevalence of skin diseases amongst fishermen, to specify the different clinical forms, associations and most frequent localisations, and to identify potential aetiological factors. The secondary objectives were to assess the knowledge, attitudes and practices of seafarers regarding occupational dermatoses to conduct information, awareness and education campaigns on risk factors and behaviours and to propose adapted prevention. MATERIALS AND METHODS: This cross-sectional survey involved 1102 artisanal fishermen who attended the annual legal medical consultation at the occupational health service...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29608022/ivermectin-and-permethrin-for-treating-scabies
#17
REVIEW
Stefanie Rosumeck, Alexander Nast, Corinna Dressler
BACKGROUND: Scabies is an intensely itchy parasitic infection of the skin. It occurs worldwide, but is particularly problematic in areas of poor sanitation, overcrowding, and social disruption. In recent years, permethrin and ivermectin have become the most relevant treatment options for scabies. OBJECTIVES: To assess the efficacy and safety of topical permethrin and topical or systemic ivermectin for scabies in people of all ages. SEARCH METHODS: We searched the following databases up to 25 April 2017: the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, and IndMED...
April 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29603527/de-novo-biosynthesis-of-non-natural-thaxtomin-phytotoxins
#18
Michael Winn, Daniel Francis, Jason Micklefield
Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity and novel mode of action there has been considerable interest in developing thaxtomins as herbicides for crop protection. To address the need for more stable derivatives, we have developed a new approach for structural diversification of thaxtomins. Genes encoding the thaxtomin NRPS from S. scabies, along with genes encoding a promiscuous tryptophan synthase (TrpS) from Salmonella typhimurium, were assembled in a heterologous host Streptomyces albus...
March 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29602574/ige-and-t-cell-responses-to-house-dust-mite-allergen-components
#19
Wayne R Thomas
Using the terminology for Dermatophagoides pteronyssinus, IgE responses to house dust mites have been shown to be mostly directed to the serodominant Der p 1, 2 and 23 allergen components with mid -tier responses to Der p 4, 5, 7 and 21 that are made by 30-50% of subjects with titers proportional to those of the serodominant specificities. This pattern can be seen to evolve in childhood and although responses to minor allergens appear to contribute little to the total IgE they are at least markers for a greater propensity to develop disease...
March 27, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29579037/scabies-in-residential-care-homes-modelling-inference-and-interventions-for-well-connected-population-sub-units
#20
Timothy Kinyanjui, Jo Middleton, Stefan Güttel, Jackie Cassell, Joshua Ross, Thomas House
In the context of an ageing population, understanding the transmission of infectious diseases such as scabies through well-connected sub-units of the population, such as residential care homes, is particularly important for the design of efficient interventions to mitigate against the effects of those diseases. Here, we present a modelling methodology based on the efficient solution of a large-scale system of linear differential equations that allows statistical calibration of individual-based random models to real data on scabies in residential care homes...
March 26, 2018: PLoS Computational Biology
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