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https://www.readbyqxmd.com/read/29137399/molecular-characteristics-and-serodiagnostic-potential-of-chitinase-like-protein-from-sarcoptes-scabiei
#1
Ran He, Nengxing Shen, Haojie Zhang, Yongjun Ren, Manli He, Jing Xu, Cheng Guo, Yue Xie, Xiaobin Gu, Weimin Lai, Xuerong Peng, Guangyou Yang
Scabies, caused by the mite Sarcoptes scabiei, is an allergic skin disease that affects millions of people and other mammals worldwide. This highly contagious parasitic disease is among the top 50 epidemic disease and is regarded as a neglected tropical disease. Diagnosis of scabies is difficult in the early stage, and the pathogenesis of scabies is not currently clear. Here, we expressed, identified and located the chitinase-like protein of S. scabiei (SsCLP), and evaluated its potential as an early-stage diagnostic antigen for rabbit scabies...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128241/-diagnosis-and-treatment-of-scabies-by-general-practitioners-a-survey-of-practices-in-france
#2
A R Schmidt-Guerre, B Aranda-Hulin, M Maumy-Bertrand, F Aubin
BACKGROUND: Although there is evidence suggesting an epidemiologic increase of scabies in France, few studies have assessed medical practice in terms of diagnosis and treatment. OBJECTIVES: To describe the management of scabies by general practitioners (GPs). PATIENTS AND METHODS: A questionnaire was addressed to the 524 GPs of the Doubs department in France regarding the management of cases of scabies diagnosed between January and June 2015...
November 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29113603/identification-of-a-novel-pyp-1-gene-in-sarcoptes-scabiei-and-its-potential-as-a-serodiagnostic-candidate-by-indirect-elisa
#3
Jing Xu, Xing Huang, Manli He, Yongjun Ren, Nengxing Shen, Chunyan Li, Ran He, Yue Xie, Xiaobin Gu, Bo Jing, Xuerong Peng, Guangyou Yang
Scabies is a parasitic disease caused by the ectoparasite Sarcoptes scabiei, affecting different mammalian species, including rabbits, worldwide. In the present study, we cloned and expressed a novel inorganic pyrophosphatase, Ssc-PYP-1, from S. scabiei var. cuniculi. Immunofluorescence staining showed that native Ssc-PYP-1 was localized in the tegument around the mouthparts and the entire legs, as well as in the cuticle of the mites. Interestingly, obvious staining was also observed on the fecal pellets of mites and in the integument of the mites...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29090458/a-narrative-review-of-dermatologic-protocols-for-primary-care-medical-service-trips-in-latin-america-and-the-caribbean
#4
Christopher Dainton, Charlene H Chu
BACKGROUND: Skin disorders are prevalent on primary care medical service trips in Latin America and the Caribbean and commonly include scabies, superficial mycoses, and pyoderma. There have been no previous attempts to describe protocols that international volunteer clinicians use in managing these patients. The purpose of this study was to collect North American clinical protocols used by sending organizations in their volunteer operations in Latin America and the Caribbean, summarize the most common pharmacologic and nonpharmacologic management strategies, and compare these to published international practice recommendations...
October 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29077242/contribution-of-the-%C3%AE-glucosidase-bglc-to-the-onset-of-the-pathogenic-lifestyle-of-streptomyces-scabies
#5
Samuel Jourdan, Isolde M Francis, Benoit Deflandre, Elodie Tenconi, Jennifer Riley, Sören Planckaert, Pierre Tocquin, Loïc Martinet, Bart Devreese, Rosemary Loria, Sébastien Rigali
Common scab disease on root and tuber plants is caused by Streptomyces scabies and related species which use the cellulose synthase inhibitor thaxtomin A as the main phytotoxin. Thaxtomin production is primarily triggered by the import of cello-oligosaccharides. Once inside the cell, the fate of the cello-oligosaccharides is dichotomized into i) fueling glycolysis with glucose for the saprophytic lifestyle through the action of β-glucosidase(s) (BG), and ii) eliciting the pathogenic lifestyle by inhibiting the CebR-mediated transcriptional repression of thaxtomin biosynthetic genes...
October 27, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29066901/increased-risk-of-pernicious-anemia-following-scabies-a-nationwide-population-based-matched-cohort-study
#6
Jui-Ming Liu, Ren-Jun Hsu, Fung-Wei Chang, Feng-Hsiang Chiu, Chia-Lun Yeh, Chun-Fa Huang, Shu-Ting Chang, Hung-Chang Lee, Hsin Chi, Chien-Yu Lin
OBJECTIVES: Scabies is a common and annoying disorder. Pernicious anemia (PA) is a serious disease which, when untreated, leads to death. Mounting evidence suggests that immune-mediated inflammatory processes play a role in the pathophysiology of both diseases. The relationship between these two diseases has not been investigated. We conducted this study to explore the potential relationship between scabies and PA. MATERIALS AND METHODS: This nationwide, population-based study was conducted using the National Health Insurance Research Database of Taiwan...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29018829/comparative-efficacy-of-topical-pertmehrin-crotamiton-and-sulfur-ointment-in-treatment-of-scabies
#7
Celestyna Mila-Kierzenkowska, Alina Woźniak, Ewa Krzyżyńska-Malinowska, Lucyna Kałużna, Roland Wesołowski, Wojciech Poćwiardowski, Marcin Owcarz
BACKGROUND: Scabies is an ectoparasitic infection, which occurs because of direct skin-to skin contact. The ideal treatment modality is still unclear and further research on this topic is warranted. The aim of the study was to compare the efficacy and safety of the topical scabicides: permethrin, crotamiton and sulfur ointment. METHODS: Fifty four patients with diagnosed scabies were randomly divided into three treatment groups. The first group received 5% permethrin cream twice with one week interval, the patients from the second group were given crotamiton lotion for two days twice with one week interval, while the third group received 10% sulfur ointment for two or three weeks...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29016306/case-report-bullous-scabies-in-two-children-below-10-years
#8
Ze-Yu Luo, Mei Zeng, Qian Gao, Yu-Kun Zhao, Rashmi Sarkar, Shu-Ping Liao, Di-Qing Luo
Bullous scabies is an infrequent and atypical presentation of scabies, with predilection for elderly and males. Its median age of presentation is 70 years. We report two male cases of bullous scabies who were 7 years and 6 months old. Both patients had excellent response to 10% sulfur ointment alone and have had no recurrence in more than 3 months of follow-up.
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016295/ignoring-the-itch-the-global-health-problem-of-scabies
#9
Lola V Stamm, Lindsay C Strowd
Infestation with Sarcoptes scabiei var. hominis is a common human parasitic affliction endemic in tropical developing countries. Scabies is transmitted by close person-person contact, and outbreaks have been reported in reception centers for asylum seekers. Scabies presents clinically as extremely pruritic excoriated papules and linear burrows in the skin. This infestation predisposes to bacterial skin infections that can result in serious complications affecting the kidneys and possibly the heart. Treatment of individuals with scabies and their close contacts involves the use of antiparasitic agents...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28989526/scabies-outbreak-among-healthcare-workers-in-a-german-acute-care-hospital
#10
Rasmus Leistner, Dirk Buchwald, Marc Beyer, Sandra Philipp
BACKGROUND: This article reports on a scabies outbreak among healthcare workers (HCW) in an acute care hospital. The outbreak was associated with a patient suffering from a chronic skin disease that was later diagnosed as crusted scabies. OBJECTIVE: The objective was to determine the outbreak drivers and define a prevention strategy against future outbreaks. METHODS: All staff that had contact with the patient were treated with 5% permethrin ointment...
July 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/28960268/mucocutaneous-manifestations-in-human-immunodeficiency-virus-hiv-infected-patients-in-nouakchott-mauritania
#11
Boushab M Boushab, Fatim-Zahra Malick Fall, Taleb K Ould Cheikh Mohamed Vadel, Mohamed L Ould Cheikh Melaïnine, Mohamed V Maazouz, Mamoudou Savadogo, Leonardo K Basco
BACKGROUND: Mucocutaneous manifestations are one of the first clinical signs in patients infected with human immunodeficiency virus (HIV). To the best of our knowledge, there has been no previous study describing dermatologic manifestations in Mauritanians infected with HIV. The aim of the present study was to determine the profiles of mucocutaneous manifestations in relation to CD4 T cell count in HIV-positive Mauritanian patients. METHODS: A total of 86 adult patients aged > 18 years old attending the Ambulatory Treatment Center of the National Hospital of Nouakchott, Mauritania, with newly diagnosed HIV and who were not under antiretroviral treatment were included in the study in 2015...
September 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28954112/norwegian-scabies-in-a-patient-treated-with-tripterygium-glycoside-for-rheumatoid-arthritis
#12
Xiaolin Bu, Juan Fan, Xiaoli Hu, Xinling Bi, Bin Peng, Denghai Zhang
We report an 80-year-old male patient with severe rheumatoid arthritis who was treated with tripterygium glycoside, an immunosuppressive agent made from the extract of a Chinese medicinal herb called Tripterygium wilfordii Hook F. The patient had no apparent skin lesions before the treatment, but he developed aggressive hyperkeratotic lesions with rapid progression after using tripterygium glycoside. He was repeatedly diagnosed with eczema, but treatment failed to achieve efficacy. Interestingly, a microscopic examination of the lesions revealed numerous scabies mites and eggs...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28948630/scabies-an-ancient-itch-that-is-still-rampant-today
#13
J Thomas, J K Christenson, E Walker, K E Baby, G M Peterson
WHAT IS KNOWN AND OBJECTIVE: Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT: There are relatively few current treatment options for scabies, and they possess important limitations. The treatments are ineffective in preventing relapse, inflammatory skin reactions and associated bacterial skin infections. There are also safety concerns, especially in children and pregnant women...
September 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28947407/skin-diseases-of-the-male-external-genitalia-in-the-tanlangai-hospital-in-brazzaville-congo
#14
E S Bayonne Kombo, A Gathse, R B Soussa, A W S Odzebe
To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. The data were processed with Epi Info 3.5.4 software. The records revealed 76 dermatoses of the male external genitalia treated in the three-year study period...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28941562/scratching-the-itch-is-scabies-a-truly-neglected-disease
#15
Olivier Chosidow, L Claire Fuller
No abstract text is available yet for this article.
September 20, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28941561/the-global-burden-of-scabies-a-cross-sectional-analysis-from-the-global-burden-of-disease-study-2015
#16
Chante Karimkhani, Danny V Colombara, Aaron M Drucker, Scott A Norton, Roderick Hay, Daniel Engelman, Andrew Steer, Margot Whitfeld, Mohsen Naghavi, Robert P Dellavalle
BACKGROUND: Numerous population-based studies have documented high prevalence of scabies in overcrowded settings, particularly among children and in tropical regions. We provide an estimate of the global burden of scabies using data from the Global Burden of Disease (GBD) Study 2015. METHODS: We identified scabies epidemiological data sources from an extensive literature search and hospital insurance data and analysed data sources with a Bayesian meta-regression modelling tool, DisMod-MR 2·1, to yield prevalence estimates...
September 20, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28938255/scabies-periorbital-cellulitis-and-recurrent-skin-abscesses-due-to-panton-valentine-leukocidin-positive-staphylococcus-aureus-mimic-hyper-ige-syndrome-in-an-infant
#17
Renate Krüger, Leif G Hanitsch, Rasmus Leistner, Sylke Schneider-Burrus, Pia-Alice Hoppe, Sylvia Steinberg, Fabian Hauck, Horst von Bernuth
We describe the clinical course of a 2-month-old infant who was evaluated for autosomal dominant Hyper IgE Syndrome based on eczema, periorbital cellulitis, skin abscesses, increased total IgE levels and blood eosinophilia. However, scabies and nasal colonization by Panton-Valentine Leucocidin-positive S. aureus were eventually diagnosed. After specific treatment, the child was asymptomatic.
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28937579/pyrethroids-inhibit-k2p-channels-and-activate-sensory-neurons-basis-of-insecticide-induced-paraesthesias
#18
Aida Castellanos, Alba Andres, Laura Bernal, Gerard Callejo, Nuria Comes, Arcadi Gual, Jonathan P Giblin, Carolina Roza, Xavier Gasull
Pyrethroid insecticides are widely used for pest control in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging sensations, and paraesthesias. Despite the well-known effects of pyrethroids on sodium channels, actions on other channels that control sensory neuron excitability are less studied. Given the role of 2-pore domain potassium (K2P) channels in modulating sensory neuron excitability and firing, both in physiological and pathological conditions, we examined the effect of pyrethroids on K2P channels mainly expressed in sensory neurons...
September 25, 2017: Pain
https://www.readbyqxmd.com/read/28924288/an-endemic-of-scabies-in-kahuta-azad-kashmir-the-study-shows-a-lack-of-awareness-of-scabies-mass-treatment-is-needed
#19
Afaque Ali
The study was planned to find the awareness of scabies in the Forward Kahuta area of Azad Jammu and Kashmir, Pakistan. For this, a questionnaire related to scabies was distributed among the patients at different walk-in clinics in the region from June 2015 to May 2016. Of the 234 participants, 97(41.5%) were males and 137(58.5%) were females. All of them reported with itching, but 120(51.3%) of the participants didn't even know that itching may be due to scabies which was found in 157(67%) patients, and of them, 106(67...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28892427/norwegian-or-crusted-sarcoptic-mange-in-two-leishmanial-dogs
#20
Flora Kaltsogianni, Rania Farmaki, Alexander F Koutinas
Norwegian or crusted scabies (N/CS) is a rare skin disease with very few cases reported in the dog or the cat. Two adult, stray dogs were admitted in our clinic with a generalized, multifocal to diffuse and nonpruritic dermatitis that was characterized by severe crusting, scaling, and ulceration. In both instances, leishmaniosis and N/CS were diagnosed by immunofluorescent antibody test serology, lymph node cytology, and skin scrapings in which high numbers of Sarcoptes mites were found. The combination of miticidal and antileishmanial treatment, supported by topical treatment and nutritional support, resulted in the complete resolution of the skin lesions and spectacular improvement of the body condition in both cases...
September 11, 2017: Journal of the American Animal Hospital Association
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