Scott H Wirth, Jafesi Pulle, JangDong Seo, Nicholas J Ollberding, Doreen Nakagaayi, Craig Sable, Asha C Bowen, Tom Parks, Jonathan Carapetis, Emmy Okello, Andrea Beaton, Emma Ndagire
BACKGROUND: Rheumatic heart disease is the largest contributor to cardiac-related mortality in children worldwide. Outcomes in endemic settings after its antecedent illness, acute rheumatic fever, are not well understood. We aimed to describe 3-5 year mortality, acute rheumatic fever recurrence, changes in carditis, and correlates of mortality after acute rheumatic fever. METHODS: We conducted a prospective cohort study of Ugandan patients aged 4-23 years who were diagnosed with definite acute rheumatic fever using the modified 2015 Jones criteria from July 1, 2017, to March 31, 2020, enrolled at three rheumatic heart disease registry sites in Uganda (in Mbarara, Mulago, or Lira), and followed up for at least 1 year after diagnosis...
March 2024: Lancet Global Health