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https://www.readbyqxmd.com/read/29029278/efficacy-and-safety-of-delafloxacin-compared-with-vancomycin-plus-aztreonam-for-acute-bacterial-skin-and-skin-structure-infections-a-phase-3-double-blind-randomized-study
#1
J Pullman, J Gardovskis, B Farley, E Sun, M Quintas, L Lawrence, R Ling, S Cammarata
Background: Delafloxacin is an investigational anionic fluoroquinolone in development for oral or intravenous administration for the treatment of infections caused by Gram-positive (including MRSA), Gram-negative, atypical and anaerobic organisms. Objectives: To establish the non-inferiority of delafloxacin compared with vancomycin plus aztreonam for the treatment of acute bacterial skin and skin structure infections and to compare the safety of the two antimicrobials...
October 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029147/maternal-and-fetal-outcomes-among-pregnant-women-with-human-monkeypox-infection-in-the-democratic-republic-of-congo
#2
Placide K Mbala, John W Huggins, Therese Riu-Rovira, Steve M Ahuka, Prime Mulembakani, Anne W Rimoin, James W Martin, Jean-Jacques T Muyembe
Human monkeypox is an endemic disease in rain-forested regions of central Democratic Republic of Congo. We report fetal outcomes for 1 of 4 pregnant women who participated in an observational study at the General Hospital of Kole (Sankuru Province), where 222 symptomatic subjects were followed between 2007 and 2011. Of the 4 pregnant women, 1 gave birth to a healthy infant, 2 had miscarriages in the first trimester, and 1 had fetal death, with the macerated stillborn showing diffuse cutaneous maculopapillary skin lesions involving the head, trunk and extremities, including palms of hands and soles of feet...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028965/tuberculin-skin-test-conversions-and-occupational-exposure-risk-in-us-healthcare-workers
#3
Claudia C Dobler, Wigdan H Farah, Mouaz Alsawas, Khaled Mohammed, Laura E Breeher, M Hassan Murad, Robin G Molella
Background: Health care workers (HCWs) undergo occupational tuberculosis (TB) screening at regular intervals. However, the risk of contracting TB at the workplace in a setting with a low background TB incidence is unclear. We aimed to evaluate the risk of tuberculin skin test (TST) conversion and the risk of occupational TB infection among HCWs in such a setting. Methods: We conducted a retrospective cohort study of employees of a large tertiary medical center in the US Midwest who had undergone TST screening during the study period January 1, 1998 to May 31, 2014...
October 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29027743/generalized-pustular-psoriasis-triggered-by-zika-virus-infection
#4
A E Paniz Mondolfi, M Hernandez Perez, G Blohm, M Marquez, A Mogollon Mendoza, C E Hernandez-Pereira, M A Escalona, A Lodeiro Colatosti, J Rothe DeArocha, A J Rodriguez Morales
Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68-year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Based on recent experimental data on the biology of ZIKV infection in the cutaneous environment, we speculate that ZIKV may have directly triggered the development of generalized pustular psoriasis by stimulation of keratinocyte-derived mediators of inflammation and a polyfunctional T-cell driven immune reaction in the cutaneous milieu...
October 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29027520/further-evidence-associating-igg1-but-not-igg2-with-susceptibility-to-canine-visceral-leishmaniasis-caused-by-leishmania-l-infantum-chagasi-infection
#5
Luciana Vieira do R Lima, Liliane Almeida Carneiro, Marliane Batista Campos, Thiago Vasconcelos Dos Santos, Patrícia Karla Ramos, Márcia Dalastra Laurenti, Claudio Eduardo C Teixeira, Fernando T Silveira
We present here a cross-sectional study analyzing the IgG1 and IgG2 immune responses to natural canine Leishmania (L.) infantum chagasi-infection and their relationships with delayed-type hypersensitivity (DTH) in 50 mongrel dogs with previous positive serodiagnoses (IFAT-IgG) (56% with subclinical status [= apparently healthy] and 44% clinically sick), living in endemic areas for visceral leishmaniasis in the Brazilian Amazon. IgG1 and IgG2 responses were measured using commercial polyclonal antibodies in ELISA, while DTH was elicited by intradermal skin test using cultured promastigotes L...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29027327/laparoscopic-ventral-hernia-repair-using-only-5-mm-ports
#6
Nicholas Bell-Allen, Harriet O'Rourke, Lisa Hong, Nicholas O'Rourke
BACKGROUND: The technique of laparoscopic ventral hernia repair has been evolving since it was first described over 20 years ago. We report a new technique where polyester mesh was back loaded through a 5-mm port site, coming into contact with the skin. This avoids the need for any 10-12-mm ports. METHODS: A prospective database of laparoscopic ventral hernia repairs was examined. A single surgeon performed 344 laparoscopic ventral hernia repairs using this technique over 60 months...
October 12, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29026866/a-prospective-observational-study-of-the-epidemiology-management-and-outcomes-of-skin-and-soft-tissue-infections-due-to-carbapenem-resistant-enterobacteriaceae
#7
Oryan Henig, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, Keith S Kaye
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29026859/molecular-identification-of-leishmania-species-in-a-re-emerged-focus-of-cutaneous-leishmaniasis-in-varamin-district-iran
#8
Mahmoodreza Behravan, Vahideh Moin-Vaziri, Ali Haghighi, Nourina Rahbarian, Niloofar Taghipour, Alireza Abadi, Homa Hajjaran
BACKGROUND: Cutaneous leishmaniasis (CL) is one of the most important neglected tropical diseases and a major public health challenge in Iran caused by Leishmania spp and transmitted by phlebotomine sand flies. The number of CL cases has shown an increasing pattern all over the country, including the district of Varamin, southeast of Tehran, Iran. This study aimed to identify the Leishmania spp isolated from CL patients using molecular methods in Varamin during 2012-2013. METHODS: Exudate materials collected from the swollen edge of the skin lesions of 44 parasitological positive CL patients by disposable lancet...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29026649/unique-genome-organization-of-non-mammalian-papillomaviruses-provides-insights-into-the-evolution-of-viral-early-proteins
#9
Koenraad Van Doorslaer, Valeria Ruoppolo, Annie Schmidt, Amelie Lescroël, Dennis Jongsomjit, Megan Elrod, Simona Kraberger, Daisy Stainton, Katie M Dugger, Grant Ballard, David G Ainley, Arvind Varsani
The family Papillomaviridae contains more than 320 papillomavirus types, with most having been identified as infecting skin and mucosal epithelium in mammalian hosts. To date, only nine non-mammalian papillomaviruses have been described from birds (n = 5), a fish (n = 1), a snake (n = 1), and turtles (n = 2). The identification of papillomaviruses in sauropsids and a sparid fish suggests that early ancestors of papillomaviruses were already infecting the earliest Euteleostomi. The Euteleostomi clade includes more than 90 per cent of the living vertebrate species, and progeny virus could have been passed on to all members of this clade, inhabiting virtually every habitat on the planet...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/29026630/sinister-seafood-bacteraemia-secondary-to-non-o1-o139-vibrio-cholerae-infection
#10
Maxime J Billick, Philip W Lam, Isaac I Bogoch
Introduction.Vibrio species are curved, motile Gram-negative bacilli found in estuarine and marine environments, and are known to cause to gastroenteritis, skin and soft tissue infections, and septicaemia. While not responsible for cholera epidemics, non-O1/O139 Vibrio cholerae (NOVC) is increasingly reported as a cause of gastroenteritis. Case presentation. A 66-year-old man presented to an emergency department with a 1 week history of epigastric pain, emesis and fever. Blood cultures drawn on admission initially demonstrated Gram-negative bacilli, and ultimately grew NOVC, which was later confirmed by matrix-assisted laser desorption ionization-time of flight MS...
July 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026623/a-case-of-vibrio-vulnificus-infection-complicated-with-fulminant-purpura-gene-and-biotype-analysis-of-the-pathogen
#11
Masatoshi Hori, Akifumi Nakayama, Daisuke Kitagawa, Hidetada Fukushima, Hideki Asai, Yasuyuki Kawai, Kazuo Okuchi
Introduction.Vibrio vulnificus (V. vulnificus) causes a severe infection that develops in the compromised host. Its pathophysiology is classified into three types: (1) primary septicaemia, (2) gastrointestinal illness pattern and (3) wound infection pattern. Of these, primary septicaemia is critical. V. vulnificus can be classified into three biotypes and two genotypes and its pathogenicity is type-dependent. Case presentation. A 47-year-old man presented to a local hospital with chief complaints of fever, bilateral lower limb pain and diarrhoea...
May 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026615/an-unusual-cutaneous-infection-caused-by-mycobacterium-marinum
#12
Federica Veronese, Elisa Zavattaro, Pamela Farinelli, Enrico Colombo, Paola Savoia
Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026476/tenofovir-induced-leukocytoclastic-vasculitis
#13
Said A Al-Busafi, Abdulatif Al-Suleimani, Aysha Al-Hamadani, Wasif Rasool
Tenofovir, a nucleotide analog, is one of the first-line medications recommended for the treatment of active chronic hepatitis B virus infection (CHB) and as a primary prophylaxis to prevent hepatitis B reactivation in cases of immunosuppression. We report the first case of tenofovir-induced leukocytoclastic vasculitis (LCV). A 43-year-old obese woman, who was known to have inactive CHB, was diagnosed with chronic immune thrombocytopenic purpura (ITP). She was treated with corticosteroid therapy and was put on tenofovir to prevent hepatitis B virus reactivation...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29025669/preparation-and-evaluation-of-squid-ink-polysaccharide-chitosan-as-a-wound-healing-sponge
#14
Na Huang, Jiali Lin, Sidong Li, Yifeng Deng, Songzhi Kong, Pengzhi Hong, Ping Yang, Mingneng Liao, Zhang Hu
A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design-response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS)...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025667/adhesion-forces-of-biofilms-developed-in-vitro-from-clinical-strains-of-skin-wounds
#15
Elizabeth Alvarado-Gomez, Mario Perez-Diaz, Donato Valdez-Perez, Jaime Ruiz-Garcia, Martin Magaña-Aquino, Gabriel Martinez-Castañon, Fidel Martinez-Gutierrez
A biofilm is a very complex consortium formed by a mix of different microorganisms, which have become an important health problem, because its formation is a resistance mechanism used by bacteria against antibiotics or the immune system. In this work, we show differences between some physicochemical properties of biofilms in mono- and multi-species, formed by bacteria from clinical samples of infected chronic wounds. Of the most prevalent bacteria in wounds, two mono- and one multi-species biofilms were developed in vitro by Drip Flow Reactor: one biofilm was developed by S...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025616/the-peroneus-brevis-flap-in-the-treatment-of-bone-infections-of-the-lower-limb
#16
Andrea Antonini, Carlo Rossello, Carlo Salomone, Giovanni Riccio, Lamberto Felli, Giorgio Burastero
The Peroneus Brevis Flap is a described option for the soft tissue coverage and for small bone gap reconstruction in the lower third of the lower leg, where few other local flaps are available and reliable. We analysed retrospectively a case series of 11 consecutive patients whose age ranged from 31 to 87 years (mean 56), who underwent a reconstruction with a PB flap in the treatment of post-traumatic bone infections from October 2010 to February 2012. In our series, only one patient at a 3 year minimum follow-up showed recurrence of the bone infection and required further surgical treatment...
October 2017: Injury
https://www.readbyqxmd.com/read/29025111/protective-effects-of-household-based-tb-interventions-are-robust-to-neighbourhood-level-variation-in-exposure-risk-in-lima-peru-a-model-based-analysis
#17
Jon Zelner, Megan Murray, Mercedes Becerra, Jerome Galea, Leonid Lecca, Roger Calderon, Rosa Yataco, Zibiao Zhang, Ted Cohen
Background: Untargeted active screening and treatment programmes for tuberculosis (TB) have not been shown to be more effective than passive screening and isoniazid preventive therapy (IPT) for reducing TB incidence. In this manuscript, we compare the efficacy of targeting screening and IPT on high-risk household contacts of diagnosed TB cases, with less-targeted active screening approaches in Lima, Peru. Methods: We conducted a population-based prospective cohort study within households of TB cases in Lima...
September 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024922/isolation-and-whole-genome-analysis-of-endospore-forming-bacteria-from-heroin
#18
Jörn Kalinowski, Björn Ahrens, Arwa Al-Dilaimi, Anika Winkler, Daniel Wibberg, Uwe Schleenbecker, Christian Rückert, Roman Wölfel, Gregor Grass
Infections caused by endospore-forming bacteria have been associated with severe illness and death among persons who inject drugs. Analysis of the bacteria residing in heroin has thus been biased towards species that affect human health. Similarly, exploration of the bacterial diversity of seized street market heroin correlated with the skin microflora of recreational heroin users insofar as different Staphylococus spp. or typical environmental endospore formers including Bacillus cereus and other Bacilli outside the B...
October 4, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29024754/comparison-of-genetic-characteristics-of-canine-papillomaviruses-in-turkey
#19
Tuba Çiğdem Oğuzoğlu, Mehmet Özkan Timurkan, Bahattin Taylan Koç, Feray Alkan
Papillomavirus (PV) infections often cause benign and malignant skin neoplasia in dogs. To date, twenty types of canine papillomaviruses (CPVs) have been described worldwide. A detailed molecular characterization of CPVs in Turkey is lacking. In the present study, oral and mucosal lesions from 13 dogs with suspected CPV infection from the Mediterranean and central Anatolian regions of Turkey were analyzed. The partial gene sequences of the L1, E6, and E7 regions were compared with those of CPV types in the GenBank database...
October 9, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29024023/chronic-active-epstein-barr-virus-infection-with-cutaneous-lymphoproliferation-haemophagocytosis-in-the-skin-and-haemophagocytic-syndrome
#20
S Tokoro, T Namiki, K Miura, K Watanabe, A Arai, K Imadome, H Yokozeki
Patients with chronic active Epstein-Barr virus (EBV) infections (CAEBV) present with cutaneous manifestations including hydroa vacciniforme-like eruptions.(1) Haemophagocytic lymphohistiocytosis (HLH), a fatal complication, can occur in severe cases of CAEBV.(2,3) We retrieved 25 cases of CAEBV treated in our hospital and histopathologically characterized the skin lesions of 3 of those cases, including one case with haemophagocytosis. This is a novel report of CAEBV with haemophagocytosis in the skin. This article is protected by copyright...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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