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https://www.readbyqxmd.com/read/28239908/pathogenicity-of-conidiobolus-coronatus-and-fusarium-solani-in-mouse-models
#1
Yadi Li, Xiangang Fang, Xiaoqian Zhou, Suying Geng, Yuxin Wang, Xiumin Yang
To study the pathogenicity of Conidiobolus coronatus (C. coronatus) and Fusarium solani (F. solani) in animal models. Immunocompromised mice were treated with cyclophosphamide and prednisolone via intraperitoneal injection before and after inoculation. According to pathogenic characteristics of different fungi, C. coronatus was used to infect mice via intravenous inoculation, intraperitoneal inoculation, gastrointestinal infusion and intradermal inoculation methods. And F. solani was used to infect mice by inoculation via the abraded or normal skin...
February 27, 2017: Mycoses
https://www.readbyqxmd.com/read/28239902/ecthyma-gangrenosum-without-bacteraemia-evidence-in-favour-of-a-broader-definition
#2
L Ferguson, H Chong, M Singh
Ecthyma gangrenosum (EG) is often defined as a cutaneous manifestation of Pseudomonas aeruginosa septicaemia, typically secondary to neutropenia. There is increasing recognition that a broader definition is warranted, as numerous causative organisms and predisposing conditions have been reported. We describe two cases of EG that occurred without bacteraemia. In this atypical subset of cases, the skin is thought to represent the primary inoculation site from which haematogenous spread can occur. The first case occurred in the context of human immunodeficiency virus (HIV) infection, a rarely reported association...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28239885/cutaneous-leishmaniasis-associated-with-anti-tumour-necrosis-factor-%C3%AE-drugs-an-emerging-disease
#3
J Marcoval, R M Penín, N Sabé, F Valentí-Medina, M Bonfill-Ortí, L Martínez-Molina
Leishmaniasis is endemic in several geographic areas of the world. In each of these areas, particular species of Leishmania with differing aggressiveness to humans predominate. In the European Mediterranean basin, cutaneous leishmaniasis usually presents with discrete, self-healing skin lesions. Although it is known that tumour necrosis factor (TNF) inhibitors may increase the risk of developing infections such as tuberculosis, there is scarce literature on Leishmania infections in patients treated with these drugs...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28239875/american-cutaneous-leishmaniasis-in-situ-immune-response-of-patients-with-recent-and-late-lesions
#4
Aparecida Helena Souza Gomes, Roosecelis Brasil Martines, Cristina Takami Kanamura, Maria Lourdes Peris Barbo, Silvia D'Andretta Iglezias, José Angelo Lauletta Lindoso, Vera Lucia Pereira-Chioccola
TNF-α, IFN-γ, IL-10, IL-17, CD68, and CD57 were evaluated in biopsies of patients with American cutaneous leishmaniasis living in Sorocaba, Brazil. The analyses were performed considering the time of lesions from 23 patients with recent lesions (Group I) and 19 patients with late lesions (Group II). All patients were infected with Leishmania (Viannia) braziliensis. Immunostaining cells for CD68, CD57, TNF- α, IFN-γ, IL-10, and IL-17 were performed by immunohistochemistry. Except for CD68 and IL-17, the distribution of in situ for CD57, IL-10, TNF-α and IFN-γ showed that patients with recent lesions expressed higher levels than those with late lesions...
February 26, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28239370/capb2-expression-is-associated-with-staphylococcus-aureus-pathogenicity
#5
Dan Li, Yinjuan Guo, Shanshan Wang, Jingnan Lv, Xiuqin Qi, Zengqiang Chen, Lizhong Han, Xueqing Zhang, Liangxing Wang, Fangyou Yu
CapB2 is recognized as a tyrosine kinase and is likely a vital factor in extracellular polysaccharide synthesis in Staphylococcus aureus, but its pathogenicity function and regulatory mechanism remain obscure. Here, we demonstrate that CapB2 enhances bacterial virulence in a murine model. Mice infected with the wild type SA75 strain exhibited significantly larger (P < 0.05) skin lesions from days 4 to 7 of infection than those challenged with the capB2 mutant strain. The effect on virulence was reverted by restoring the capB2 mutation to the wild type...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28238880/analysis-on-the-expression-and-function-of-a-chicken-type-and-goose-type-lysozymes-in-chinese-giant-salamanders-andrias-davidianus
#6
Hui Yang, Ranran Liu, Dan Cui, Haixia Liu, Dongmei Xiong, Xiaolin Liu, Lixin Wang
Lysozymes as an important immune factor, play vital roles in innate immune response against pathogen infection. In the present study, one c-type and g-type lysozymes were identified from Chinese giant salamander (Andrias davidianus). They shared highly conserved structural features with lysozymes from other species. Spatial expression analysis revealed that AdlysC transcript was most abundant in liver and stomach, and least in muscle and brain. In contrast, the expression level of AdlysG was most abundant in liver and least in muscle and skin...
February 23, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28238633/early-neonatal-death-a-challenge-worldwide
#7
REVIEW
Liisa Lehtonen, Ana Gimeno, Anna Parra-Llorca, Máximo Vento
Early neonatal death (ENND), defined as the death of a newborn between zero and seven days after birth, represents 73% of all postnatal deaths worldwide. Despite a 50% reduction in childhood mortality, reduction of ENND has significantly lagged behind other Millennium Developmental Goal achievements and is a growing contributor to overall mortality in children aged <5 years. The etiology of ENND is closely related to the level of a country's industrialization. Hence, prematurity and congenital anomalies are the leading causes in high-income countries...
February 23, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28238336/human-papilloma-virus-dermatosis-in-human-immunodeficiency-virus-positive-patients-a-14-year-retrospective-study-in-965-patients
#8
Almudena Nuno-Gonzalez, Juan Emilio Losa Garcia, José Luis López Estebaranz, María Dolores Martin-Rios
INTRODUCTION: The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients. PATIENTS AND METHODS: Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. We analyzed patients' demographic factors and factors related to the HPV...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28238217/antibacterial-and-anti-biofilm-effects-of-sodium-hypochlorite-against-staphylococcus-aureus-isolates-derived-from-patients-with-atopic-dermatitis
#9
S Eriksson, M J A van der Plas, M Mörgelin, A Sonesson
INTRODUCTION: Atopic dermatitis (AD) is characterised by an increased susceptibility for skin infections. Staphylococcus aureus is reported to dominate in AD lesions and reports have revealed the presence of staphylococcal biofilms. These infections contribute to aggravating the eczema. Sodium hypochlorite is known to reduce bacterial load of skin lesions as well as disease severity in AD patients but the effect on biofilms is unknown. OBJECTIVES: The aim of this study was to investigate the antimicrobial and anti-biofilm effects of sodium hypochlorite against S...
February 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28237775/new-insights-into-the-ameliorative-effects-of-ferulic-acid-in-pathophysiological-conditions
#10
REVIEW
Sumit Ghosh, Priyanka Basak, Sayanta Dutta, Sayantani Chowdhury, Parames C Sil
Ferulic acid, a natural phytochemical has gained importance as a potential therapeutic agent by virtue of its easy commercial availability, low cost and minimal side-effects. It is a derivative of curcumin and possesses the necessary pharmacokinetic properties to be retained in the general circulation for several hours. The therapeutic effects of ferulic acid are mediated through its antioxidant and anti-inflammatory properties. It exhibits different biological activities such as anti-inflammatory, anti-apoptotic, anti-carcinogenic, anti-diabetic, hepatoprotective, cardioprotective, neuroprotective actions, etc...
February 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28237766/n-acetylcysteine-inhibits-growth-adhesion-and-biofilm-formation-of-gram-positive-skin-pathogens
#11
Daria Eroshenko, Tatyana Polyudova, Vladimir Korobov
N-Acetylcysteine (NAC) is a non-antibiotic drug with antimicrobial properties against biofilm phenotypes of Gram-positive and Gram-negative bacteria. Our aim was to assess the effects of NAC on the growth of Gram-positive human skin and mucous membrane pathogens in the planktonic and biofilm phases. The minimum inhibitory concentrations (MICs) of NAC against Enterococcus faecalis, Corynebacterium ammoniagenes, Mycobacterium smegmatis, Propionibacterium acnes, Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes, and 14 clinical strains of coagulase-negative staphylococci (CNS) ranged from 0...
February 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28237623/effect-of-underlying-immune-compromise-on-the-manifestations-and-outcomes-of-group-a-streptococcal-bacteremia
#12
Kathleen A Linder, Leen Alkhouli, Mayur Ramesh, George A Alangaden, Carol A Kauffman, Marisa H Miceli
BACKGROUND: Group A streptococcal bloodstream infection is the most common presentation of invasive group A streptococcal disease. We sought to determine the impact of immunosuppression on severity of disease and clinical outcomes. METHODS: This retrospective review of 148 patients with at least one positive blood culture for Streptococcus pyogenes from 1/2003 to 3/2013 compared immunocompromised patients with those with no immunocompromise in regards to development of severe complications and mortality...
February 22, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28237374/intertrigo-caused-by-streptococcus-pyogenes
#13
Anca Chiriac, Alina Murgu, Marius Florin Coroș, Adrian Naznean, Cristian Podoleanu, Simona Stolnicu
Well-demarcated, beefy-red lesions of the skin folds, without satellite lesions, are the clinical hallmarks of intertrigo, frequently misdiagnosed especially in young children. We present 6 cases of streptococcal intertrigo to draw attention to this easily diagnosed and treated, but frequently overlooked, infection.
February 22, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28236847/is-von-willebrand-disease-linked-to-cholesteatoma-aetiology
#14
 Reis Rego, M Santos, M Coutinho, T Feliciano, C Almeida E Sousa
Cholesteatoma is a common clinical picture seen by otolaryngologists. The disease is characterised by an abnormal grow "of skin in the wrong place". Specifically, in acquired cholesteatoma, the main causative issue is associated with ventilatory deficits within the middle ear and results in chronic infection. Molecular science has associated the presence of specific molecules with its development, and moreover recent research suggests that deregulated angiogenesis is a crucial process in the development of cholesteatoma and its recurrence...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28235982/-transcutaneous-osseointegration-after-limb-amputation-a-review-over-27-years
#15
Horst-Heinrich Aschoff
Intramedullary, bone-anchored (osseointegrated), transcutaneous docking of artificial limbs has been in clinical use for more than 25 years. This system of prosthetic limb attachment is a valuable treatment option in the rehabilitation of patients after limb amputation. Only a few centers are systematically investigating this topic worldwide so that current knowledge on this special treatment option is still limited; however, mainstream medical opinion still regards percutaneous skeletal prosthetic docking with some skepticism...
February 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28231455/synthetic-investigation-physicochemical-characterization-and-antibacterial-evaluation-of-ternary-bi-iii-systems-with-hydroxycarboxylic-acid-and-aromatic-chelator-substrates
#16
C M Nday, E Halevas, A Tsiaprazi-Stamou, D Eleftheriadou, A Hatzidimitriou, G Jackson, D Reid, A Salifoglou
Due to its physical and chemical properties, bismuth (Bi(III)) is widely used in the treatment of several gastrointestinal and skin diseases, and infections caused by bacteria. Herein, its known antimicrobial potential was taken into consideration in the synthesis of two new hybrid ternary materials of Bi(III) with the physiological α-hydroxycarboxylic glycolic acid and 1,10-phenanthroline (phen), [Bi2(C2H2O3)2(C2H3O3)(NO3)]n(.) nH2O (1) and [Bi(C12H8N2)(NO3)4](C10H8N4) (2), aiming at improving its antibacterial properties...
February 11, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28231023/increasing-nocardia-incidence-associated-with-bronchiectasis-at-a-tertiary-care-center
#17
Michael H Woodworth, Jennifer L Saullo, Paul M Lantos, Gary M Cox, Jason E Stout
RATIONALE: Nocardia is a genus of pathogens that most commonly afflicts immunocompromised hosts, but may be an emerging infection among persons with bronchiectasis. OBJECTIVES: To examine the epidemiology and clinical presentation of adult patients with Nocardia and bronchiectasis relative to other patient groups. METHODS: We examined a retrospectively-assembled cohort of adults at Duke University Hospital in Durham, North Carolina with at least one positive culture from a bodily fluid or tissue specimen for Nocardia between January 1996 and December 2013...
February 23, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28229358/postmastectomy-radiation-therapy-and-breast-reconstruction-with-autologous-tissue
#18
Yasunobu Terao, Koichiro Taniguchi, Miwako Fujii, So Moriyama
Immediate breast reconstruction is an important tool for patients to accept and overcome their breast cancer, as well as for cosmetic reasons. However, its use in patients who require postmastectomy radiation therapy (PMRT) is not yet clear. The purpose of this study was to analyze the effects of PMRT and reconstruction on each other. The time of initiation of PMRT, the prognosis, and the cosmetic results were investigated in patients who underwent immediate reconstruction using autologous tissue. In the case of delayed reconstruction using autologous tissue after PMRT, radiation damage of the chest skin, design of the flap, and cosmetic results were investigated...
February 22, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28229229/management-of-unstable-distal-third-clavicle-fractures-clinical-and-radiological-outcomes-of-the-arthroscopy-assisted-conoid-ligament-reconstruction-and-fracture-cerclage-with-sutures
#19
Luis Natera Cisneros, Juan Sarasquete Reiriz
INTRODUCTION: Surgical treatment is indicated for the management of Neer type IIB fractures of the distal third of the clavicle. The aim of this study was to assess the clinical and radiological outcomes, in cases of unstable distal third clavicle fractures managed by means of an arthroscopy-assisted conoid ligament reconstruction and fracture cerclage with sutures. METHODS: Nine patients with unstable distal third clavicle fractures (Neer type IIB) managed arthroscopically by means of a conoid ligament reconstruction and fracture cerclage with sutures, between 2008 and 2012, were included...
February 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28228944/semi-closed-surgical-technique-for-treatment-of-pilonidal-sinus-disease
#20
Georgios Sahsamanis, Stavros Samaras, Georgios Mitsopoulos, Titos Deverakis, Georgios Dimitrakopoulos, Dionysios Pinialidis
INTRODUCTION: Pilonidal sinus disease (PSD) is a highly debatable disorder regarding its surgical management, despite an assortment of surgical techniques described in the medical literature. The aim of this report is to provide an alternate semi-closed surgical method for treatment of PSD, with early recovery and a satisfactory cosmetic result. METHODS: In this retrospective study, 34 patients underwent surgical treatment for primary PSD; 32 male and 2 female. Patients were suffering from primary PSD, with the cyst located in the gluteal midline...
March 2017: Annals of Medicine and Surgery
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