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pancreatic tumours

Emre Demirci, Levent Kabasakal, Turkay Toklu, Meltem Ocak, Onur E Şahin, Nalan Alan-Selcuk, Ahmet Araman
PURPOSE: Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively investigated its efficacy and effect on the survival in patients with both well-differentiated and grade III NETs who had high uptake in pretherapeutic Ga-DOTATATE PET/computed tomography scans...
June 15, 2018: Nuclear Medicine Communications
S Balakrishnan, S Kapoor, P Vijayanath, H Singh, A Nandhakumar, K Venkatesulu, V Shanmugam
Coeliac artery stenosis (CAS) is rarely of consequence owing to rich collateral supply from the superior mesenteric artery via the pancreatic head. Pancreaticoduodenectomy (PD) in CAS disrupts these collaterals, and places the liver, stomach and spleen at risk of ischaemia. A 56-year-old man presented with a 3-week history of obstructive jaundice. Computed tomography revealed an operable periampullary tumour with CAS due to compression by the median arcuate ligament with multiple collaterals in the pancreatic head and a prominent gastroduodenal artery (GDA)...
June 18, 2018: Annals of the Royal College of Surgeons of England
Sheng Wang, Yiqun Lei, Zeling Cai, Xiaoman Ye, Lianhong Li, Xiagang Luo, Chunzhao Yu
Girdin functions as an Akt phosphorylation enhancer (APE), which expedites the proliferation and survival of many types of tumours. However, the influence of Girdin on pancreatic cancer and the underlying molecular mechanisms have yet to be uncovered. Hence, in the present study, we sought to elucidate the function of Girdin in pancreatic cancer malignancy, particularly its role in pancreatic cancer cell proliferation, migration and apoptosis. Immunohistochemistry (IHC) was used to evaluate Girdin expression in pancreatic cancer tissues and to analyse its correlation with pathological grade...
May 31, 2018: Oncology Reports
Yongquan Lin, Lihua Rong, Jingrong Zhao, Ronghui Lin, Shuhua Li
MicroRNAs (miRNAs) possess oncogenic and tumour‑suppressive roles in the carcinogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) by regulating the expression of numerous cancer‑related genes. Thus, the investigation on the expression and roles of miRNAs in PDAC may facilitate the identification of novel and effective targets for the clinical diagnosis and treatment of patients with PDAC. miRNA‑539 (miR‑539) has been studied in multiple types of human cancer. However, its expression and potential biological function in PDAC remain unclear...
May 31, 2018: Molecular Medicine Reports
Remy Klaassen, Oliver J Gurney-Champion, Marc R W Engelbrecht, Jaap Stoker, Johanna W Wilmink, Marc G Besselink, Arjan Bel, Geertjan van Tienhoven, Hanneke W M van Laarhoven, Aart J Nederveen
PURPOSE: To compare 6 diffusion-weighted imaging (DWI) MRI models for response evaluation in patients with pancreatic ductal adenocarcinoma (PDAC). MATERIALS AND METHODS: DWI images were acquired at 3T for b = 0-600 s/mm2 in fourteen patients with advanced PDAC during 2 separate pretreatment sessions and 9 patients with (borderline) resectable PDAC pre and post neoadjuvant chemoradiation. Data was fitted with a mono-exponential (ADC), double mono-exponential to b = 0 and 100 s/mm2 (ADCfast ), and b = 100 and 600 s/mm2 (ADCslow ), IVIM model with D* free (D, f, D*) and fixed (D, f), tri-exponent (D, f1 , f2 ), and stretched exponent model (DDC, α)...
May 4, 2018: International Journal of Radiation Oncology, Biology, Physics
Kumar Vinchurkar, Vishwanath M Pattanshetti, Manoj Togale, Santosh Hazare, Varadraj Gokak
Currently, pancreaticoduodenectomy (PD) is considered a common and feasibly performed surgery for periampullary tumours, but it is still a high-risk surgical procedure with potential morbidity and mortality rates. Previously, it was emphasised for the need of high-volume centres to perform specialised surgery such as PD. The authors have made an attempt to know the relation between low-volume centre and outcomes of PD. The study was conducted in a Tier-II city referral hospital located in Karnataka, India. A total of 37 patients with suspected periampullary neoplasms underwent surgical exploration with curative intent over a period of 4 years, i...
June 2018: Indian Journal of Surgical Oncology
K L Zhao, J Liu, W N Jiang, J H Hao
Objective: To investigate the prognostic effect of tumour-infiltrating immune cell, including CD8(+) T cell, regulatory T-cell (Treg) and myeloid-derived suppressor cells (MDSC) on pancreatic patients. Methods: This study retrospectively collected the data of 80 patients who were histologically diagnosed of pancreatic cancer and underwent classical R0 surgical resection at Tianjin Medical University Cancer Institute and Hospital from January 2010 to May 2012. All patients survival were followed up until the cut-off date of January 2015...
June 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Yudi Zhu, Shaosi Liang, Huafeng Pan, Zhongliang Cheng, Xin Rui
Recently, microRNA-1247 (miR-1247) has been reported to function as tumour suppressor in several cancer types, including pancreatic cancer, hepatocellular cancer and lung cancer. However, the biological function of miR-1247 in bladder cancer and the underlying mechanisms have remained largely uncovered. In this study, the expression of miR-1247 was significantly downregulated, while RAB36 protein was remarkably upregulated in bladder cancer tissues and cell lines compared with that in paired adjacent normal tissues or normal cell line (SU-HUC-1)...
June 2018: Journal of Biosciences
Philippe Bulens, Melissa Thomas, Christophe M Deroose, Karin Haustermans
Radiotherapy is the standard of care in the multimodality treatment of a variety of gastrointestinal (GI) tumours, such as oesophageal cancer, gastric cancer, rectal cancer and anal cancer. Additionally, radiotherapy has served as an alternative for surgery in patients with liver cancer, cancer of the biliary tract and pancreatic cancer. Positron-emission tomography (PET), generally in combination with computed tomography (CT), has an established role in the diagnosis, response assessment and (re-)staging of several GI tumours...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Maria Luisa Belli, Martina Mori, Sara Broggi, Giovanni Mauro Cattaneo, Valentino Bettinardi, Italo Dell'Oca, Federico Fallanca, Paolo Passoni, Emilia Giovanna Vanoli, Riccardo Calandrino, Nadia Di Muzio, Maria Picchio, Claudio Fiorino
PURPOSE: To investigate the robustness of PET radiomic features (RF) against tumour delineation uncertainty in two clinically relevant situations. METHODS: Twenty-five head-and-neck (HN) and 25 pancreatic cancer patients previously treated with 18 F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)-based planning optimization were considered. Seven FDG-based contours were delineated for tumour (T) and positive lymph nodes (N, for HN patients only) following manual (2 observers), semi-automatic (based on SUV maximum gradient: PET_Edge) and automatic (40%, 50%, 60%, 70% SUV_max thresholds) methods...
May 2018: Physica Medica: PM
Célia Cintas, Thibaut Douché, Nicole Therville, Silvia Arcucci, Fernanda Ramos-Delgado, Céline Basset, Benoît Thibault, Julie Guillermet-Guibert
For patients with metastatic pancreatic cancer that are not eligible for surgery, signal-targeted therapies have so far failed to significantly improve survival. These therapeutic options have been tested in phase II/III clinical trials mostly in combination with the reference treatment gemcitabine. Innovative therapies aim to annihilate oncogenic dependency, or to normalize the tumoural stroma to allow immune cells to function and/or re-vascularisation to occur. Large scale transcriptomic and genomic analysis revealed that pancreatic cancers display great heterogeneity but failed to clearly delineate specific oncogene dependency, besides oncogenic Kras...
June 1, 2018: Cancers
Maria Antonietta Bali, Serena Pullini, Thierry Metens, Julie Absil, Shih-Li Chao, Raphael Marechal, Celso Matos, Bibi Mooneera Peerboccus, Jean-Luc Van Laethem
PURPOSE: To prospectively assess chemotherapy-induced changes in pancreatic ductal adenocarcinoma (PDA) with diffusion-weighted (DW)-MR quantitative metrics, including apparent diffusion coefficient (ADC) and histogram-derived parameters, compared with RECIST 1.1. METHODS: 24 patients underwent DW-MR at baseline, week-2 and week-8 after chemotherapy initiation. Tumour diameter was assessed on T2-weighted images. Regions-of-interest (ROI) were drawn on ADC map for ROI-ADC...
July 2018: European Journal of Radiology
Yukai Xiang, Wen Ye, Chaohao Huang, Dinglai Yu, Hao Chen, Tuo Deng, Fan Zhang, Bin Lou, Jie Zhang, Keqing Shi, Bicheng Chen, Mengtao Zhou
Although gemcitabine is the standard chemotherapy treatment for advanced pancreatic cancer, its benefits are quite limited due to prevalent chemoresistance, and the mechanism underlying gemcitabine chemoresistance remains unclear. Currently, Nrf2 has been deemed as a significant contributor to gemcitabine chemoresistance in pancreatic cancer. Brusatol is a unique inhibitor of the Nrf2 pathway, and in previous studies, we determined that brusatol exhibits the effects of growth inhibition and proapoptosis in pancreatic cancer cells...
2018: Oxidative Medicine and Cellular Longevity
Sadaf Batool, Awais Amjad Malik, Hassaan Bari, Irfan Ul Islam, Faisal Hanif
Option for borderline resectable pancreatic cancer is pancreaticoduodenectomy (PD) with vascular resection and reconstruction. We would like to share our experience of vascular reconstruction. First patient was a 51-year male with pancreatic head carcinoma, involving posterior wall of portal vein (PV) and replacing right hepatic artery (RHA). Along with PD, he underwent PV and RHA resection and reconstruction. Second case was a 33-year female who had distal pancreatic cyst and PV-splenic vein junction involved by tumor...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Jack D Godfrey, Jennifer P Morton, Ania Wilczynska, Owen J Sansom, Martin D Bushell
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognostic implications. This is partly due to a large proportion of PDACs carrying mutations in TP53, which impart gain-of-function characteristics that promote metastasis. There is evidence that microRNAs (miRNAs) may play a role in both gain-of-function TP53 mutations and metastasis, but this has not been fully explored in PDAC. Here we set out to identify miRNAs which are specifically dysregulated in metastatic PDAC. To achieve this, we utilised established mouse models of PDAC to profile miRNA expression in primary tumours expressing the metastasis-inducing mutant p53R172H and compared these to two control models carrying mutations, which promote tumour progression but do not induce metastasis...
May 29, 2018: Cell Death & Disease
Caroline Verbeke, Lena Häberle, Daniela Lenggenhager, Irene Esposito
Neoadjuvant treatment has increasingly become an integral part of the multimodal management of patients with pancreatic cancer. In patients who are able to undergo surgery following preoperative therapy, tumour regression grading remains the diagnostic gold standard for the histomorphological assessment of the effect of neoadjuvant treatment. In recent years, however, there has been growing concern about inherent flaws of tumour regression grading systems as well as their imprecise and impractical criteria that result in divergence of practice and lack of interobserver agreement...
April 25, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Tinghui Jiang, Qiuying Li, Ping Xiao, Yan Liu, Kai Wang, Xiaofei Liang, Xianjun Sun
Circulating tumour cells isolated from the peripheral blood of patients have the advantage of being non-invasive. The aim of this study was to develop an effective method for detecting pancreatic cancer micrometastasis from peripheral blood and explore the clinical application value of the separation of circulating pancreatic cancer cells using epithelial cell adhesion molecule (EpCAM) lipid magnetic spheres (ELMS) and plastin monoclonal antibody for identification. The pancreatic cancer PANC-1 cells were respectively added to phosphate-buffered saline (PBS) and fresh blood provided by healthy volunteers to detect cell recovery using ELMS...
June 1, 2018: Journal of Biomedical Nanotechnology
S Drápela, R Fedr, P Khirsariya, K Paruch, M Svoboda, K Souček
BACKGROUND: Nucleoside analogues represent a relevant class of antimetabolites used for therapy of various types of cancer. However, their effectivity is limited by drug resistance. The nucleoside transport capability of tumour cells is considered to be a determinant of the clinical outcome of treatment regimens using antimetabolites. Due to hydrophilic properties of antimetabolites, their transport across the plasma membrane is mediated by two families of transmembrane proteins, the SLC28 family of cation-linked concentrative nucleoside transporters (hCNTs) and SLC29 family of energy-independent equilibrative nucleoside transporters (hENTs)...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Marta Łukaszewicz-Zając, Mariusz Gryko, Barbara Mroczko
Pancreatic carcinoma is a highly malignant disease associated with an extremely poor prognosis, which is caused by late presentation, aggressive invasion and metastases, as well as the detection of pancreatic carcinoma in its advanced stages. Thus, better understanding of the tumour biology of this malignancy is sorely needed to improve the clinical outcome. A great challenge for the medical practice is finding a new biomarker of pancreatic carcinoma that will be helpful in diagnosis, in prognosis and in making clinical decisions, including the assessment of patients' response to therapy...
May 2018: International Journal of Biological Markers
Brian K P Goh, Tze-Yi Low, Ser-Yee Lee, Chung-Yip Chan, Alexander Y F Chung, London L P J Ooi
BACKGROUND: Presently, the worldwide experience with robotic pancreatic surgery (RPS) is increasing although widespread adoption remains limited. In this study, we report our initial experience with RPS. METHODS: This is a retrospective review of a single institution prospective database of 72 consecutive robotic hepatopancreatobiliary surgeries performed between 2013 and 2017. Of these, 30 patients who underwent RPS were included in this study of which 25 were performed by a single surgeon...
May 24, 2018: ANZ Journal of Surgery
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