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Sharee Kuny, Marc-André Filion, Miyoung Suh, Frédéric Gaillard, Yves Sauvé
PURPOSE: To examine the pattern of cone degeneration in the retina of a transgenic mouse model of Stargartd-like dystrophy (STGD3). METHODS: Investigations were performed on ELOVL4/TG1-2 transgenic (TG) mice and wild-type (WT) littermates from 1 to 24 months of age. Phenotypes were assessed by fundus imaging, fatty acid analysis, and electroretinogram (ERG) recording. Cone degeneration pattern was determined on retina whole mounts using immunohistochemistry and Voronoi domain analyses...
January 2014: Investigative Ophthalmology & Visual Science
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