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Daniel J Peart, Richard J Kirk, Leigh A Madden, Rebecca V Vince
The aim of this study was to investigate if a pre-exercise alkalosis-mediated attenuation of HSP72 had any effect on the response of the same stress protein after a subsequent exercise. Seven physically active males [25.0 ± 6.5 years, 182.1 ± 6.0 cm, 74.0 ± 8.3 kg, peak aerobic power (PPO) 316 ± 46 W] performed a repeated sprint exercise (EXB1) following a dose of 0.3 g kg(-1) body mass of sodium bicarbonate (BICARB), or a placebo of 0.045 g kg(-1) body mass of sodium chloride (PLAC). Participants then completed a 90-min intermittent cycling protocol (EXB2)...
February 2016: Amino Acids
Michael E Percival, Brian J Martin, Jenna B Gillen, Lauren E Skelly, Martin J MacInnis, Alex E Green, Mark A Tarnopolsky, Martin J Gibala
We tested the hypothesis that ingestion of sodium bicarbonate (NaHCO3) prior to an acute session of high-intensity interval training (HIIT) would augment signaling cascades and gene expression linked to mitochondrial biogenesis in human skeletal muscle. On two occasions separated by ∼1 wk, nine men (mean ± SD: age 22 ± 2 yr, weight 78 ± 13 kg, V̇O(2 peak) 48 ± 8 ml·kg(-1)·min(-1)) performed 10 × 60-s cycling efforts at an intensity eliciting ∼90% of maximal heart rate (263 ± 40 W), interspersed with 60 s of recovery...
December 1, 2015: Journal of Applied Physiology
Miles D Witham, Margaret M Band, Roberta C Littleford, Alison Avenell, Roy L Soiza, Marion E T McMurdo, Deepa Sumukadas, Simon A Ogston, Edmund J Lamb, Geeta Hampson, Paul McNamee
BACKGROUND: Metabolic acidosis is more common with advancing chronic kidney disease, and has been associated with impaired physical function, impaired bone health, accelerated decline in kidney function and increased vascular risk. Although oral sodium bicarbonate is widely used to correct metabolic acidosis, there exist potential risks of therapy including worsening hypertension and fluid overload. Little trial evidence exists to decide whether oral bicarbonate therapy is of net benefit in advanced chronic kidney disease, particularly in older people who are most commonly affected, and in whom physical function, quality of life and vascular health are at least as important outcomes as decline in renal function...
2015: Trials
Junbao Yu, Fanzhu Qu, Huifeng Wu, Ling Meng, Siyao Du, Baohua Xie
Modified Hedley fraction method was used to study the forms and profile distribution in the tidal river network region subjected to rapid deposition and hydrologic disturbance in the Yellow River Delta (YRD) estuary, eastern China. The results showed that the total P (Pt) ranged from 612.1 to 657.8 mg kg(-1). Dilute HCl extractable inorganic P (Pi) was the predominant form in all profiles, both as absolute values and as a percentage of total extracted Pi. The NaOH extractable organic P (Po) was the predominant form of total extracted Po, while Bicarb-Pi and C...
2014: TheScientificWorldJournal
Matthew J Northgraves, Daniel J Peart, Christian A Jordan, Rebecca V Vince
The use of nutritional supplements to improve sporting performance and increase training adaptations is commonplace among athletes and is an expanding market in terms of product choice and availability. The purpose of this study was to examine the effects of 2 ergogenic aids with extracellular blood buffering potential, namely sodium bicarbonate (NaHCO3) and a lactate supplement, during a 40-km cycling time trial. Seven recreationally active men (age, 22.3 ± 3.3 years; height, 182.5 ± 6.5 cm; body mass, 79...
January 2014: Journal of Strength and Conditioning Research
Daniel J Peart, Richard J Kirk, Angela R Hillman, Leigh A Madden, Jason C Siegler, Rebecca V Vince
The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg(-1) body mass of sodium bicarbonate (NaHCO(3)) (BICARB), or a placebo of 0.045 g kg(-1) body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0...
January 2013: European Journal of Applied Physiology
Eugenio José Garcia, Tatiane Luiza Cadorin Oldoni, Severino Matias de Alencar, Alessandra Reis, Alessandro D Loguercio, Rosa Helena Miranda Grande
The aim of this study was to assess, using the DPPH assay, the antioxidant activity of several substances that could be proposed to immediately revert the problems caused by bleaching procedures. The percentage of antioxidant activity (AA%) of 10% ascorbic acid solution (AAcidS), 10% ascorbic acid gel (AAcidG), 10% sodium ascorbate solution (SodAsS), 10% sodium ascorbate gel (SodAsG), 10% sodium bicarbonate (Bicarb), Neutralize(®) (NE), Desensibilize(®) (DES), catalase C-40 at 10 mg/mL (CAT), 10% alcohol solution of alpha-tocopherol (VitE), Listerine(®) (LIS), 0...
2012: Brazilian Dental Journal
L A González, A Ferret, X Manteca, S Calsamiglia
Four Holstein heifers (264 ± 12 kg initial BW) were used in a 4 × 4 Latin square design with 21-day experimental periods to determine the effect of increasing levels of sodium bicarbonate (BICARB) (0%, 1.25%, 2.5% and 5%, of concentrate dry matter (DM) basis) on chewing and feed intake behavior when fed high-concentrate diets. Concentrate (13.41% CP, 13.35% NDF) and barley straw were fed once a day at 0830 h ad libitum. Feed bunks placed on scales and video recording were used to measure 24-h feed intake and chewing behavior, respectively...
May 2008: Animal: An International Journal of Animal Bioscience
L A González, A Ferret, X Manteca, S Calsamiglia
Four ruminally fistulated Holstein heifers (BW = 264 ± 12 kg) were used in a 4 × 4 Latin square design experiment to determine the effect of increasing levels of sodium bicarbonate (BICARB; 0%, 1.25%, 2.50% and 5%, on concentrate dry matter (DM) basis) on DM intake (DMI), water consumption and ruminal fermentation. Sampling was carried out in the last week of each four 21-day experimental periods. Heifers were offered concentrate (13.4 ± 0.04% crude protein (CP), 13.3 ± 0.44% NDF, 51.7 ± 0.97% starch) and barley straw once daily at 0830 h ad libitum...
May 2008: Animal: An International Journal of Animal Bioscience
Maryam Baeeri, Marjan Shariatpanahi, Amir Baghaei, Seyedeh Farnaz Ghasemi-Niri, Hamidreza Mohammadi, Azadeh Mohammadirad, Shokoufeh Hassani, Zahra Bayrami, Asieh Hosseini, Seyed Mahdi Rezayat, Mohammad Abdollahi
The present study was designed to determine the effect of a new (25)Mg(2+)-carrying nanoparticle ((25)MgPMC16) on energy depletion, oxidative stress, and electrocardiographic (ECG) parameters on heart tissue of the rats poisoned by aluminum phosphide (AlP). (25)MgPMC16 at doses of 0.025, 0.05, and 0.1 median lethal dose (LD50 = 896 mg/kg) was administered intravenously (iv) 30 min after a single intragastric administration of AlP (0.25 LD50). Sodium bicarbonate (Bicarb; 2 mEq/kg, iv) was used as the standard therapy...
March 2013: Toxicology and Industrial Health
Chao Li, Libin Zhang, Lili Ding, Hongqiang Ren, Hao Cui
Conductive polymer, one of the most attractive electrode materials, has been applied to coat anode of MFC to improve its performance recently. In this paper, two conductive polymer materials, polyaniline (PANI) and poly(aniline-co-o-aminophenol) (PAOA) were used to modify carbon felt anode and physical and chemical properties of the modified anodes were studied. The power output and biodiversity of modified anodes, along with unmodified carbon anode were compared in two-chamber MFCs. Results showed that the maximum power density of PANI and PAOA MFC could reach 27...
June 15, 2011: Biosensors & Bioelectronics
S Volianitis, P Rasmussen, T Seifert, H B Nielsen, N H Secher
Exercise lowers the cerebral metabolic ratio of O2 to carbohydrate (glucose+1/2 lactate) and metabolic acidosis appears to promote cerebral lactate uptake. However, the influence of pH on cerebral lactate uptake and, in turn, on the cerebral metabolic ratio during exercise is not known. Sodium bicarbonate (Bicarb, 1 M; 350-500 ml) or an equal volume of normal saline (Sal) was infused intravenously at a constant rate during a '2000 m' maximal ergometer row in six male oarsmen (23±2 years; mean±S.D.). During the Sal trial, pH decreased from 7...
January 15, 2011: Journal of Physiology
Katherine M Bakes, Jeff Faragher, Vince J Markovchick, Kevin Donahoe, Jason S Haukoos
OBJECTIVES: Anion gap (AG) and serum bicarbonate concentration (BICARB) may help confirm a diagnosis of seizure in an unwitnessed collapse; however, little data exist to support this practice. Our objective was to assess the association between AG metabolic acidosis and generalized seizure and to derive a simple score to predict seizure. METHODS: This was a case-control study at an urban teaching hospital. Patients transported to our emergency department with witnessed loss of consciousness and final confirmed diagnoses of generalized seizure (cases) or syncope (controls) were eligible for enrollment...
November 2011: American Journal of Emergency Medicine
Jason C Siegler, Damien O Gleadall-Siddall
The purpose of the present investigation was to observe the ergogenic potential of 0.3 g·kg-1 of sodium bicarbonate (NaHCO3) in competitive, nonelite swimmers using a repeated swim sprint design that eliminated the technical component of turning. Six male (181.2 ± 7.2 cm; 80.3 ± 11.9 kg; 50.8 ± 5.5 ml·kg-1·min-1 VO2max) and 8 female (168.8 ± 5.6 cm; 75.3 ± 10.1 kg; 38.8 ± 2.6 ml·kg-1·min-1 VO2max) swimmers completed 2 trial conditions (NaHCO3 [BICARB] and NaCl placebo [PLAC]) implemented in a randomized (counterbalanced), single blind manner, each separated by 1 week...
November 2010: Journal of Strength and Conditioning Research
J C Siegler, L R McNaughton, A W Midgley, S Keatley, A Hillman
Pre-exercise alkalosis and an active recovery improve the physiological state of recovery through slightly different mechanisms (e. g. directly increasing extracellular bicarbonate (HCO3 (-)) vs. increasing blood flow), and combining the two conditions may provide even greater influence on blood acid-base recovery from high-intensity exercise. Nine subjects completed four trials (Placebo Active ( PLAC A), sodium bicarbonate (NaHCO3) Active ( BICARB A), Placebo Passive ( PLAC P) and NaHCO3 Passive ( BICARB P)), each consisting of three, 30-s maximal efforts with a three min recovery between each effort...
November 2010: International Journal of Sports Medicine
Robert C De Lisle
Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is still not completely understood. In this issue of the JCI, Garcia and colleagues show that mucin--the heavily glycosylated protein contained within mucus--requires CFTR and bicarbonate in order to be released from mouse intestine (see the related article beginning on page 2613)...
September 2009: Journal of Clinical Investigation
Jason C Siegler, Kristian Hirscher
Boxing is a sport that consists of multiple high-intensity bouts separated by minimal recovery time and may benefit from a pre-exercise alkalotic state. The purpose of this study was to observe the ergogenic potential of sodium bicarbonate (NaHCO3) ingestion on boxing performance. Ten amateur boxers volunteered to participate in 2 competitive sparring bouts. The boxers were prematched for weight and boxing ability and consumed either 0.3 body weight (BW) of NaHCO3 (BICARB) or 0.045 BW of NaCl placebo (PLAC) mixed in diluted low calorie-flavored cordial...
January 2010: Journal of Strength and Conditioning Research
J C Siegler, S Keatley, A W Midgley, A M Nevill, L R McNaughton
The aim of this study was to observe the influence of pre-exercise sodium bicarbonate (NaHCO3) ingestion and varying recovery modes on acid-base recovery from a single bout of supramaximal exercise. Nine male subjects completed four separate, randomized cycle ergometer exercise trials to volitional fatigue at 120% maximum power output, under the following conditions: 0.3 BW NaHCO3 ingestion with passive recovery (BICARB P), 0.3 (-1) BW NaHCO3 ingestion with active recovery (BICARB A), placebo ingestion with passive recovery (PLAC P) and placebo ingestion with active recovery (PLAC A)...
July 2008: International Journal of Sports Medicine
L Lokesh, P Kumar, S Murki, A Narang
UNLABELLED: Very little evidence is available that supports or disproves the use of medications in neonatal resuscitation. In this randomized controlled trial, we evaluated the effect of sodium bicarbonate given during neonatal resuscitation, on survival and neurological outcome at discharge. SUBJECTS AND METHODS: Consecutively born asphyxiated neonates continuing to need positive pressure ventilation at 5min of life received either sodium bicarbonate or 5% dextrose...
February 2004: Resuscitation
S B Shew, P R Beckett, T H Keshen, F Jahoor, T Jaksic
The use of a stable isotope-labeled [13C]bicarbonate infusion to measure energy expenditure is advantageous, as a complete collection of expired air is not required. This technique allows for facile measurements of energy expenditure in intubated neonates. The aim of the present study was to determine the accuracy of energy expenditure estimates in postsurgical neonates by using the [13C]bicarbonate method compared with the current standard, indirect calorimetry. Eight neonates who were receiving total parenteral nutrition [98 +/- 21 (SD) kcal x kg(-1) x d(-1); 3...
June 2000: Pediatric Research
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