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https://www.readbyqxmd.com/read/29791244/the-need-for-mapping-personal-goals-to-exercise-dosage-in-community-based-exercise-programs-for-people-with-parkinson-s-disease
#1
Allison L Amateis, Chelsea L Boesel, Bryan P Ehnert, Abby S Evans, Katheryn E Hurst, Katie L Marek, Amanda C Sullivan, Kathryn R Zalewski, Wendy E Huddleston
PURPOSE: Community-based exercise can support long-term management of Parkinson's disease, although it is not known if personal goals are met in these programs. The objectives of this study were to: (1) examine the goals of community based exercise programs from the participant and instructor perspectives; (2) establish the extent to which these programs meet self-described exercise outcomes; and (3) explore participant and instructor perspectives on barriers to meeting exercise expectations...
May 23, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29790385/kinect4fog-monitoring-and-improving-mobility-in-people-with-parkinson-s-using-a-novel-system-incorporating-the-microsoft-kinect-v2
#2
Amin Amini, Konstantinos Banitsas, William R Young
Parkinson's is a neurodegenerative condition associated with several motor symptoms including tremors and slowness of movement. Freezing of gait (FOG); the sensation of one's feet being "glued" to the floor, is one of the most debilitating symptoms associated with advanced Parkinson's. FOG not only contributes to falls and related injuries, but also compromises quality of life as people often avoid engaging in functional daily activities both inside and outside the home. In the current study, we describe a novel system designed to detect FOG and falling in people with Parkinson's (PwP) as well as monitoring and improving their mobility using laser-based visual cues cast by an automated laser system...
May 23, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29785679/drooling-in-parkinson-s-disease-evidence-of-a-role-for-divided-attention
#3
Hannah Reynolds, Nick Miller, Richard Walker
Drooling is a frequently reported symptom in Parkinson's Disease (PD) with significant psychosocial impact and negative health consequences including silent aspiration of saliva with the associated risk of respiratory infections. It is suggested that in PD drooling is associated with inefficient oropharyngeal swallowing which reduces the effective clearance of saliva rather than hyper-salivation. This is compounded by unintended mouth opening and flexed posture increasing anterior loss of saliva. It is reported to occur most frequently during cognitively distracting concurrent tasks suggesting an impact from divided attention in a dual-task situation...
May 21, 2018: Dysphagia
https://www.readbyqxmd.com/read/29785228/evaluating-the-utility-of-a-structured-clinical-protocol-for-reducing-the-impact-of-behavioural-and-psychological-symptoms-of-dementia-in-progressive-neurological-diseases-a-pilot-study
#4
Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29783725/polyphenols-in-parkinson-s-disease-a-systematic-review-of-in-vivo-studies
#5
REVIEW
Małgorzata Kujawska, Jadwiga Jodynis-Liebert
Parkinson's disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic agents. Herein, we have attempted to summarize results obtained in different animal models demonstrating their neuroprotective effects. The in vivo findings presented below are supported by human subject data and reports regarding the ability of polyphenols to cross the blood-brain barrier...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29782440/management-for-simultaneous-patella-tendon-and-anterior-cruciate-ligament-ruptures-a-systematic-review-of-available-literature
#6
Alexander Handel Matthews, Ethan James Fraser, Benjamin Parkinson
BACKGROUND: Combined rupture of the anterior cruciate ligament (ACL) and patella tendon (PT) is a rare injury pattern. Currently little evidence exists to help guide management decisions for these patients. METHODS: A systematic literature search was conducted using PubMed (MEDLINE) and Scopus (EMBASE, MEDLINE) for all articles reporting on combined rupture of the anterior cruciate ligament (ACL) and patella tendon (PT). The characteristic injury mechanisms, common presentation findings and outcomes of simultaneous and staged treatment strategies were determined to provide guidance for the management of this uncommon injury pattern...
May 15, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29782061/improving-self-management-for-persons-with-parkinson-s-disease-through-education-focusing-on-management-of-daily-life-patients-and-relatives-experience-of-the-swedish-national-parkinson-school
#7
Carina Hellqvist, Nil Dizdar, Peter Hagell, Carina Berterö, Märta Sund Levander
AIMS AND OBJECTIVE: The two folded aim of this study was firstly to identify and describe experiences valuable for managing daily life after participation in the NPS self-management intervention. The second part was to explore the applicability of the Self- and family management framework by Grey and colleagues for persons with Parkinson's Disease and their relatives. BACKGROUND: The impact of PD is evident on the lives of both patients and relatives. The National Parkinson School (NPS) is a Swedish self-management program designed for patients and relatives, aiming at teaching strategies helpful for the ability of self-management, in order to promote life satisfaction...
May 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29780321/toll-like-receptor-2-signaling-and-current-approaches-for-therapeutic-modulation-in-synucleinopathies
#8
REVIEW
Ian F Caplan, Kathleen A Maguire-Zeiss
The innate immune response in the central nervous system (CNS) is implicated as both beneficial and detrimental to health. Integral to this process are microglia, the resident immune cells of the CNS. Microglia express a wide variety of pattern-recognition receptors, such as Toll-like receptors, that detect changes in the neural environment. The activation of microglia and the subsequent proinflammatory response has become increasingly relevant to synucleinopathies, including Parkinson's disease the second most prevalent neurodegenerative disease...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29774765/-staying-safe-a-narrative-review-of-falls-prevention-in-people-with-parkinson-s-pdsafe
#9
Sophia Hulbert, Lynn Rochester, Alice Nieuwboer, Vicki Goodwin, Carolyn Fitton, Kim Chivers-Seymour, Ann Ashburn
BACKGROUND: Parkinson's disease demonstrates a spectrum of motor and non-motor symptoms. Falling is common and disabling. Current medical management shows minimal impact to reduce falls or fall-related risk factors, such as deficits in gait, strength, and postural instability. Despite evidence supporting rehabilitation in reducing fall risk factors, the most appropriate intervention to reduce overall fall rate remains inconclusive. This article aims to 1) synthesise current evidence and conceptual models of falls rehabilitation in Parkinson's in a narrative review; and based on this evidence, 2) introduce the treatment protocol used in the falls prevention and multi-centre clinical trial "PDSAFE"...
May 18, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29764353/non-motor-parkinson-disease-new-concepts-and-personalised-management
#10
Nataliya Titova, K Ray Chaudhuri
Most patients with Parkinson disease (PD) have non-motor symptoms (NMS), and on average these can range from four to 19 different symptoms. NMS dominate the prodromal phase of PD and some may serve as clinical biomarkers of PD. NMS can be dopaminergic, non-dopaminergic, of genetic origin or drug induced. Clinical assessment of NMS should include the NMS Questionnaire (completed by patients) for screening, as recommended by the International Parkinson and Movement Disorders Society and other international societies...
May 21, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29761156/viewpoint-and-practical-recommendations-from-a-movement-disorder-specialist-panel-on-objective-measurement-in-the-clinical-management-of-parkinson-s-disease
#11
REVIEW
Per Odin, K Ray Chaudhuri, Jens Volkmann, Angelo Antonini, Alexander Storch, Espen Dietrichs, Zvezdan Pirtošek, Tove Henriksen, Malcolm Horne, David Devos, Filip Bergquist
Motor aspects of Parkinson's disease, such as fluctuations and dyskinesia, can be reliably evaluated using a variety of "wearable" technologies, but practical guidance on objective measurement (OM) and the optimum use of these devices is lacking. Therefore, as a first step, a panel of movement disorder specialists met to provide guidance on how OM could be assessed and incorporated into clinical guidelines. A key aspect of the incorporation of OM into the management of Parkinson's disease (PD) is defining cutoff values that separate "controlled" from "uncontrolled" symptoms that can be modified by therapy and that relate to an outcome that is relevant to the person with PD (such as quality of life)...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29756227/the-genetic-nomenclature-of-recessive-cerebellar-ataxias
#12
REVIEW
Malco Rossi, Mathieu Anheim, Alexandra Durr, Christine Klein, Michel Koenig, Matthis Synofzik, Connie Marras, Bart P van de Warrenburg
The recessive cerebellar ataxias are a large group of degenerative and metabolic disorders, the diagnostic management of which is difficult because of the enormous clinical and genetic heterogeneity. Because of several limitations, the current classification systems provide insufficient guidance for clinicians and researchers. Here, we propose a new nomenclature for the genetically confirmed recessive cerebellar ataxias according to the principles and criteria laid down by the International Parkinson and Movement Disorder Society Task Force on Classification and Nomenclature of Genetic Movement Disorders...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29755536/preclinical-study-of-ibuprofen-loaded-transnasal-mucoadhesive-microemulsion-for-neuroprotective-effect-in-mptp-mice-model
#13
Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Krutika K Sawant, Bharat Bhushan Subudhi
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administration further limits its utility. Hence, the aim of this study was to investigate whether ibuprofen loaded mucoadhesive microemulsion (MMEI) could enhance the brain uptake and could also protect the dopaminergic neurons from MPTP-mediated neural inflammation. In this work, ibuprofen loaded polycarbophil based mucoadhesive microemulsion (MMEI) was developed by using response surface methodology (RSM)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29755356/anti-parkinson-potential-of-silymarin-mechanistic-insight-and-therapeutic-standing
#14
REVIEW
Hammad Ullah, Haroon Khan
Parkinson's disease (PD) involves aggregation of α-synuclein and progressive loss of dopaminergic neurons. Pathogenesis of PD may also be related to one's genetic background. PD is most common among geriatric population and approximately 1-2% of population suffers over age 65 years. Currently no successful therapies are in practice for the management of PD and available therapies tend to decrease the symptoms of PD only. Furthermore, these are associated with diverse range of adverse effects profile. The neuroprotective effects of polyphenols are widely studied and documented...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29754758/novel-valosin-containing-protein-mutations-associated-with-multisystem-proteinopathy
#15
Sejad Al-Tahan, Ebaa Al-Obeidi, Hiroshi Yoshioka, Anita Lakatos, Lan Weiss, Marjorie Grafe, Johanna Palmio, Matt Wicklund, Yadollah Harati, Molly Omizo, Bjarne Udd, Virginia Kimonis
Over fifty missense mutations in the gene coding for valosin-containing protein (VCP) are associated with a unique autosomal dominant adult-onset progressive disease associated with combinations of proximo-distal inclusion body myopathy (IBM), Paget's disease of bone (PDB), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS). We report the clinical, histological, and molecular findings in four new patients/families carrying novel VCP mutations: c.474 G > A (p.M158I); c.478 G > C (p...
April 17, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29751602/old-drugs-as-new-treatments-for-neurodegenerative-diseases
#16
REVIEW
Fernando Durães, Madalena Pinto, Emília Sousa
Neurodegenerative diseases are increasing in number, given that the general global population is becoming older. They manifest themselves through mechanisms that are not fully understood, in many cases, and impair memory, cognition and movement. Currently, no neurodegenerative disease is curable, and the treatments available only manage the symptoms or halt the progression of the disease. Therefore, there is an urgent need for new treatments for this kind of disease, since the World Health Organization has predicted that neurodegenerative diseases affecting motor function will become the second-most prevalent cause of death in the next 20 years...
May 11, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29748111/dat-spect-imaging-in-cases-of-drug-induced-parkinsonism-in-a-specialty-movement-disorders-practice
#17
Jacob Yomtoob, Kimberly Koloms, Danny Bega
OBJECTIVE: Compare clinical characteristics and outcomes in cases where DAT-SPECT imaging is used to distinguish Parkinson's disease from Drug-Induced Parkinsonsim. BACKGROUND: Clinical uncertainty in diagnosing Parkinson's disease is common when patients are on dopamine-blocking medications. DAT-SPECT imaging can improve diagnostic certainty but little data are available on clinical characteristics and outcomes associated with normal and abnormal scan results. METHODS: Retrospective chart review of patients seen at a movement disorders center between 2011 and 2017 where DAT-SPECT was ordered to distinguish Parkinson's disease from Drug-induced Parkinsonism...
May 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29746402/update-in-therapeutic-strategies-for-parkinson-s-disease
#18
Jaime Kulisevsky, Lais Oliveira, Susan H Fox
PURPOSE OF REVIEW: To review recent advances in therapeutics for motor and nonmotor symptoms of Parkinson's disease. RECENT FINDINGS: Neuroprotection remains a large area of investigation with preliminary safety data on alpha synuclein immunotherapy and glucagon-like peptide-1 agonists. Novel Monoamine Oxidase B and Caetchol-O-methyltransferase-inhibitors for motor fluctuations have shown benefit and are recently approved for clinical use. Long-acting amantadine has also been approved to reduce dyskinesia...
May 8, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29739324/zinc-and-linoleic-acid-pre-treatment-attenuates-biochemical-and-histological-changes-in-the-midbrain-of-rats-with-rotenone-induced-parkinsonism
#19
Ngala Elvis Mbiydzenyuy, Herbert Izo Ninsiima, Miriela Betancourt Valladares, Constant Anatole Pieme
BACKGROUND: Studies have suggested the supplementation of Zinc and Linoleic acid in the management of neurodegenerative disorders but none has investigated the combined effects. Little is known about the neuroprotective effects of either Zinc or Linoleic acid or their combination against development of Parkinsonism. This study was designed to investigate the neuroprotective effects of Zinc and Linoleic acid in rotenone-induced Parkinsonism in rats. METHODS: Thirty-six young adult female rats weighing 100-150 g divided into six groups were used...
May 9, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29738432/neuroimmunology-research-a-report-from-the-cuban-network-of-neuroimmunology
#20
María de Los Angeles Robinson-Agramonte, Lourdes Lorigados Pedre, Orlando Ramón Serrano-Barrera
Neuroimmunology can be traced back to the XIX century through the descriptions of some of the disease’s models (e.g., multiple sclerosis and Guillain Barret syndrome, amongst others). The diagnostic tools are based in the cerebrospinal fluid (CSF) analysis developed by Quincke or in the development of neuroimmunotherapy with the earlier expression in Pasteur’s vaccine for rabies. Nevertheless, this field, which began to become delineated as an independent research area in the 1940s, has evolved as an innovative and integrative field at the shared edges of neurosciences, immunology, and related clinical and research areas, which are currently becoming a major concern for neuroscience and indeed for all of the scientific community linked to it...
May 8, 2018: Behavioral Sciences
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