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https://www.readbyqxmd.com/read/28087304/sleep-and-neurodegeneration-a-critical-appraisal
#1
REVIEW
Jagan A Pillai, James B Leverenz
Sleep abnormalities are clearly recognized as distinct clinical symptom of concern in neurodegenerative disorders. Appropriate management of sleep related symptoms has a positive impact on the quality of life of patients with neurodegenerative disorders. This review provides an overview of mechanisms that are currently being considered that tie sleep with neurodegeneration. It appraises the literature regarding specific sleep changes among common neurodegenerative diseases with a focus on Alzheimer's disease and synucleinopathies (i...
January 10, 2017: Chest
https://www.readbyqxmd.com/read/28081533/eeg-monitoring-technique-influences-the-management-of-hypoxic-ischemic-seizures-in-neonates-undergoing-therapeutic-hypothermia
#2
Saber Jan, Frances J Northington, Charlamaine M Parkinson, Carl E Stafstrom
Electroencephalogram (EEG) monitoring techniques for neonatal hypoxia-ischemia (HI) are evolving over time, and the specific type of EEG utilized could influence seizure diagnosis and management. We examined whether the type of EEG performed affected seizure treatment decisions (e.g., the choice and number of antiseizure drugs [ASDs]) in therapeutic hypothermia-treated neonates with HI from 2007 to 2015 in the Johns Hopkins Hospital Neonatal Intensive Care Unit. During this period, 3 different EEG monitoring protocols were utilized: Period 1 (2007-2009), single, brief conventional EEG (1 h duration) at a variable time during therapeutic hypothermia treatment, i...
January 17, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28074748/possible-parkinson-s-disease-induced-by-chronic-manganese-supplement-ingestion
#3
Michael J Schuh
OBJECTIVE: The objective is to report a case of possible neurotoxicity resulting from an incorrect dietary supplement for osteoporosis taken at a toxic dose. SUMMARY: The case study examined here is a 37-year-old African-American female who consumed excessive manganese over a period of years, resulting in Parkinson's disease (PD). This patient was referred to the pharmacist pharmacotherapy service by a neurology physician. PD has been shown in the medical literature to be caused by chronic exposure to high levels of manganese...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28073650/the-utilisation-of-one-district-hospital-emergency-department-by-people-with-parkinson-s-disease
#4
Marion Harris, Margaret Fry
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder in Australia and the economic burden is more than $8.3 billion a year and predicted to escalate. However, little is known of the trends and characteristics of people with Parkinson's disease presenting to emergency departments (ED). METHOD: The study design was a 12 month retrospective medical record audit. The study was conducted in one metropolitan 300 bed district hospital in an outer suburb of Sydney...
January 7, 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/28069007/the-benzopyrone-biochanin-a-as-a-reversible-competitive-and-selective-monoamine-oxidase-b-inhibitor
#5
Najla O Zarmouh, Suresh K Eyunni, Karam F A Soliman
BACKGROUND: Monoamine oxidase-B (MAO-B) inhibitors are widely used in the treatment of Parkinson's disease. They increase vital monoamine neurotransmitters in the brain. However, there is a need for safer natural reversible MAO inhibitors with MAO-B selectivity. Our previous studies showed that Psoralea corylifolia seeds (PCS) extract contains compounds that inhibit monoamine oxidase-B. METHODS: In this study, six of PCS constituents sharing a benzopyrone structure were investigated...
January 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28066979/when-proteostasis-goes-bad-protein-aggregation-in-the-cell
#6
REVIEW
Mona Radwan, Rebecca J Wood, Xiaojing Sui, Danny M Hatters
Protein aggregation is a hallmark of the major neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's and motor neuron and is a symptom of a breakdown in the management of proteome foldedness. Indeed, it is remarkable that under normal conditions cells can keep their proteome in a highly crowded and confined space without uncontrollable aggregation. Proteins pose a particular challenge relative to other classes of biomolecules because upon synthesis they must typically follow a complex folding pathway to reach their functional conformation (native state)...
January 9, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28063896/clinical-correlation-of-abnormal-findings-on-magnetic-resonance-elastography-in-idiopathic-normal-pressure-hydrocephalus
#7
Avital Perry, Christopher S Graffeo, Nikoo Fattahi, Mona M ElSheikh, Nealey Cray, Arvin Arani, Richard L Ehman, Kevin J Glaser, Armando Manduca, Fredric B Meyer, John Huston
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is ventriculomegaly syndrome characterized by dementia, urinary incontinence, and gait disturbance, which is potentially reversible following ventriculoperitoneal shunting (VPS). Magnetic resonance elastography (MRE) is an evolving imaging technology that noninvasively measures tissue viscoelasticity. OBJECTIVE: We studied iNPH patients using MRE prior to shunting, compared them to normal controls, and analyzed associations between MRE findings and clinical features, as a pilot assessment of MRE in iNPH...
January 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28063757/-no-motor-signs-in-parkinson-s-disease
#8
Jean-Philippe Azulay, Tatiana Witjas, Alexandre Eusebio
In Parkinson's disease, motor signs have long been the main targets of the management of the disease. In recent years, non-motor disorders have elicited increasing interest. These disorders are under diagnosed and managed more difficultly than motor signs and are sometimes perceived as more disturbing by the patients. These signs are polymorphous, sometimes occurring before the motor symptoms but increase with the disease duration and complicating always the late stages. They may fluctuate as the motor signs, while being under the control of dopaminergic pathways, or be linked to the degeneration of other neuronal circuits...
January 4, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28063683/diphasic-dyskinesias-during-levodopa-carbidopa-intestinal-gel-lcig-infusion-in-parkinson-s-disease
#9
Meloni Mario, Solla Paolo, Mascia Mario Marcello, Marrosu Francesco, Cannas Antonino
OBJECTIVES: Levodopa-carbidopa intestinal gel infusion (LCIG) is indicated in patients with advanced levodopa-responsive Parkinson's disease (PD) for the treatment of motor fluctuations and dyskinesias. Here we describe 4 PD patients who developed disabling diphasic dyskinesias after LCIG initiation. METHODS: The clinical data of 33 PD patients consecutively treated with LCIG therapy were obtained through direct clinical observation and detailed review of medical records...
December 31, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28057301/axgxe-using-flies-to-interrogate-the-complex-etiology-of-neurodegenerative-disease
#10
C Burke, K Trinh, V Nadar, S Sanyal
Progressive and late-onset neurological disorders such as Parkinson's disease and Alzheimer's disease affect up to 50 million people globally-a number postulated to double every 20 years in a continually aging population. While predisposing allelic variants in several genes clearly confer risk, individual age and specific environmental influences are equally important discriminators of disease onset age and progression. However, none of these factors can independently predict disease with significant precision...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28054129/the-relevance-of-gender-in-parkinson-s-disease-a-review
#11
REVIEW
Marina Picillo, Alessandra Nicoletti, Vincenza Fetoni, Barbara Garavaglia, Paolo Barone, Maria Teresa Pellecchia
Since the official and systematic inclusion of sex and gender in biomedical research, gender differences have been acknowledged as important determinants of both the susceptibility to develop neurodegenerative diseases in general population and the clinical and therapeutic management of neurodegenerative patients. In this review, we gathered the available evidence on gender differences in Parkinson's disease (PD) regarding clinical phenotype (including motor and non-motor symptoms), biomarkers, genetics and therapeutic management (including pharmacological and surgical treatment)...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28050656/the-recommendations-of-a-consensus-panel-for-the-screening-diagnosis-and-treatment-of-neurogenic-orthostatic-hypotension-and-associated-supine-hypertension
#12
REVIEW
Christopher H Gibbons, Peter Schmidt, Italo Biaggioni, Camille Frazier-Mills, Roy Freeman, Stuart Isaacson, Beverly Karabin, Louis Kuritzky, Mark Lew, Phillip Low, Ali Mehdirad, Satish R Raj, Steven Vernino, Horacio Kaufmann
Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management. To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards 'best practices' when treating patients with nOH and associated supine hypertension...
January 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28049252/neurological-complications-resulting-from-non-oral-occupational-methanol-poisoning
#13
Ji Hyun Choi, Seung Keun Lee, Young Eun Gil, Jia Ryu, Kyunghee Jung-Choi, Hyunjoo Kim, Jun Young Choi, Sun Ah Park, Hyang Woon Lee, Ji Young Yun
Methanol poisoning results in neurological complications including visual disturbances, bilateral putaminal hemorrhagic necrosis, parkinsonism, cerebral edema, coma, or seizures. Almost all reported cases of methanol poisoning are caused by oral ingestion of methanol. However, recently there was an outbreak of methanol poisoning via non-oral exposure that resulted in severe neurological complications to a few workers at industrial sites in Korea. We present 3 patients who had severe neurological complications resulting from non-oral occupational methanol poisoning...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28038673/feature-visualization-and-classification-for-the-discrimination-between-individuals-with-parkinson-s-disease-under-levodopa-and-dbs-treatments
#14
Alessandro R P Machado, Hudson Capanema Zaidan, Ana Paula Souza Paixão, Guilherme Lopes Cavalheiro, Fábio Henrique Monteiro Oliveira, João Areis Ferreira Barbosa Júnior, Kheline Naves, Adriano Alves Pereira, Janser Moura Pereira, Nader Pouratian, Xiaoyi Zhuo, Andrew O'Keeffe, Justin Sharim, Yvette Bordelon, Laurice Yang, Marcus Fraga Vieira, Adriano O Andrade
BACKGROUND: Over the years, a number of distinct treatments have been adopted for the management of the motor symptoms of Parkinson's disease (PD), including pharmacologic therapies and deep brain stimulation (DBS). Efficacy is most often evaluated by subjective assessments, which are prone to error and dependent on the experience of the examiner. Our goal was to identify an objective means of assessing response to therapy. METHODS: In this study, we employed objective analyses in order to visualize and identify differences between three groups: healthy control (N = 10), subjects with PD treated with DBS (N = 12), and subjects with PD treated with levodopa (N = 16)...
December 30, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28028671/anesthesia-considerations-for-patients-with-an-implanted-deep-brain-stimulator-undergoing-surgery-a-review-and-update
#15
Tze Yeng Yeoh, Pirjo Manninen, Suneil K Kalia, Lashmi Venkatraghavan
PURPOSE: Deep brain stimulation (DBS) can be an effective treatment option for patients with essential tremor and Parkinson's disease. This review provides an overview on the functioning of neurostimulators and recent advances in this technology and presents an updated guide on the anesthetic management of patients with an implanted neurostimulator undergoing surgery or medical intervention. SOURCE: A search was conducted on MEDLINE®, EMBASE™, and Cochrane Database of Systematic Reviews databases to identify studies published in English from 1974 to December 2015...
December 27, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28027343/recommendations-for-the-treatment-of-patients-with-parkinson-disease-during-ramadan
#16
Philippe Damier, Jasem Al-Hashel
Importance: Every year, Ramadan fasting is practiced by many Muslim individuals. In cases of chronic disease, religious texts allow fasting to be broken. However, many believers still want to fast even at the risk of damaging their health. To our knowledge, there are no published recommendations on the medical management of Parkinson disease (PD) during Ramadan. Effective treatments exist in PD and usually require several daily drug intakes. Apart from worsening symptoms, interrupting PD treatment might lead to a severe withdrawal syndrome...
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/28027070/innovations-in-functional-neurosurgery-and-anesthetic-implications
#17
Lauren K Dunn, Marcel E Durieux, W Jeffrey Elias, Edward C Nemergut, Bhiken I Naik
Functional neurosurgery has undergone rapid growth over the last few years fueled by advances in imaging technology and novel treatment modalities. These advances have led to new surgical treatments using minimally invasive and precise techniques for conditions such as Parkinson's disease, essential tremor, epilepsy, and psychiatric disorders. Understanding the goals and technological issues of these procedures is imperative for the anesthesiologist to ensure safe management of patients presenting for functional neurosurgical procedures...
December 23, 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28017151/synopsis-on-managing-strategies-for-neurodegenerative-disorders-challenges-from-bench-to-bedside-in-successful-drug-discovery-and-development
#18
Sheraz Ahmad Bhat, Mohammad Amjad Kamal, Ghulam Md Ashraf
The maintenance of health requires successful cell functioning which in turn depends upon the proper and active conformation of proteins besides other biomolecules. However, occasionally these proteins may misfold and lead to the appearance and progression of protein conformational diseases. These diseases apart from others include several neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson's disease, Huntington disease, multiple sclerosis, amyotrophic lateral sclerosis, and other less well known diseases...
December 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28007002/physical-therapy-and-occupational-therapy-in-parkinson-s-disease
#19
Danielle L M Radder, Ingrid H Sturkenboom, Marlies van Nimwegen, Samyra H Keus, Bastiaan R Bloem, Nienke M de Vries
Current medical management is only partially effective in controlling the symptoms of Parkinson's disease. As part of comprehensive multidisciplinary care, physical therapy and occupational therapy aim to support people with Parkinson's disease in dealing with the consequences of their disease in daily activities. In this narrative review, we address the limitations that people with Parkinson's disease may encounter despite optimal medical management, and we clarify both the unique and shared approaches that physical therapists and occupational therapists can apply in treating these limitations...
December 22, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28000926/virtual-reality-for-rehabilitation-in-parkinson-s-disease
#20
REVIEW
Kim Dockx, Esther Mj Bekkers, Veerle Van den Bergh, Pieter Ginis, Lynn Rochester, Jeffrey M Hausdorff, Anat Mirelman, Alice Nieuwboer
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder that is best managed by a combination of medication and regular physiotherapy. In this context, virtual reality (VR) technology is proposed as a new rehabilitation tool with a possible added value over traditional physiotherapy approaches. It potentially optimises motor learning in a safe environment, and by replicating real-life scenarios could help improve functional activities of daily living. OBJECTIVES: The objective of this review was to summarise the current best evidence for the effectiveness of VR interventions for the rehabilitation of people with PD in comparison with 1) active interventions, and 2) passive interventions...
December 21, 2016: Cochrane Database of Systematic Reviews
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