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Suzanne Gonzalez, Jayanta Gupta, Erika Villa, Indika Mallawaarachchi, Marco Rodriguez, Mercedes Ramirez, Juan Zavala, Regina Armas, Albana Dassori, Javier Contreras, Deborah Flores, Alvaro Jerez, Alfonso Ontiveros, Humberto Nicolini, Michael Escamilla
OBJECTIVES: Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these polymorphisms would also be associated with BD in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with BD and/or SC and ancestral haploblocks containing these single nucleotide polymorphisms (SNPs) in a sample of Latino subjects with BD...
September 2016: Bipolar Disorders
Aysu Arslan, Soner Çakmak, Alper Cengiz, Menemşe Gümüşderelioğlu
The aliphatic-aromatic copolyester, poly(butylene adipate-co-terephthalate) (PBAT) combines good mechanical and thermal properties with biodegradation ability. However, until now, researches in its potential medical use remain limited. Only in a few studies blends of PBAT with routinely used biocompatible polymers had been prepared and investigated regarding tissue engineering applications. Therefore, in this study, we decided to determine processability of neat PBAT as a scaffold material for bone tissue by using different fabrication methods i...
October 10, 2016: Journal of Biomaterials Science. Polymer Edition
Marcos Mariano, Nadia El Kissi, Alain Dufresne
Composite materials were prepared by extrusion and injection molding from polybutyrate adipate terephthalate (PBAT) and high aspect ratio cellulose nanocrystals (CNCs) extracted from capim dourado fibers. Three CNC contents were used, corresponding to 0.5, 1, and 2 times the theoretical percolation threshold. Small-amplitude oscillary shear (SAOS) experiments show that as the CNC content increases, a more elastic behavior is observed but no percolating network can form within the polymeric matrix as a result of the high shear rates involved during the injection-molding process...
October 4, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Ju Yup Lee, Nayoung Kim, Kyung Sik Park, Hyun Jin Kim, Seon Mee Park, Gwang Ho Baik, Ki-Nam Shim, Jung Hwan Oh, Suck Chei Choi, Sung Eun Kim, Won Hee Kim, Seon-Young Park, Gwang Ha Kim, Bong Eun Lee, Yunju Jo, Su Jin Hong
BACKGROUND: The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resistance to tetracycline or to amoxicillin is relatively low. A 14-day modified bismuth quadruple protocol as first-line H. pylori treatment was compared with 10-day sequential therapy. METHODS: In total, 390 H. pylori-infected subjects participated in the randomized clinical trial: 10-day sequential therapy (40 mg pantoprazole plus 1 g amoxicillin twice a day for 5 days, then 40 mg pantoprazole and 500 mg clarithromycin twice a day and 500 mg metronidazole three times a day for 5 days) or 14-day modified bismuth quadruple therapy (40 mg pantoprazole, 600 mg bismuth subcitrate, 1 g tetracycline, and 1 g amoxicillin, twice a day)...
2016: BMC Gastroenterology
Ling Zhang, Ren Zhang, Mingxia Gao, Xiangmin Zhang
A bioorthogonal Raman reporter-embedded Au-core and polydopamine-shell nanoprobe was initially designed and synthesized for live cell surface-enhanced Raman scattering (SERS) imaging in Raman-silent region. The firstly synthetic bioorthogonal Raman reporter (E)-2- ((4-(phenylethynyl) benzylidene)amino)ethanethiol (PBAT) provided intense Raman signal at 2220cm(-1) in Raman-silent region. And its synthetic method was environmentally benign, high yield and easy in operation. In addition, the hydrophobicity of PBAT led to slightly aggregation of gold nanoparticles, which enhance the SERS intensity of the nanoprobe through hot spots...
September 1, 2016: Talanta
Yichen Guo, Shan He, Kai Yang, Yuan Xue, Xianghao Zuo, Yingjie Yu, Ying Liu, Chung-Chueh Chang, Miriam H Rafailovich
"Green" polymer nanocomposites were made by melt blending biodegradable poly(lactic acid) (PLA) and poly(butylene adipate-co-butylene terephthalate) (PBAT) with either montmorillonite clays (Cloisite Na(+)), halloysite nanotubes (HNTs), the resorcinol diphenyl phosphate (RDP)-coated Cloisite Na(+), and coated HNTs. A technique for measuring the work of adhesion (Wa) between nanoparticles and their matrixes was used to determine the dispersion preference of the nanoparticles in the PLA/PBAT blend system. Transmission electron microscopy (TEM) images of thin sections indicated that even though both RDP-coated nanotubes and clay platelets segregated to the interfacial regions between the two immiscible polymers, only the platelets, having the larger specific surface area, were able to reduce the PBAT domain sizes...
July 13, 2016: ACS Applied Materials & Interfaces
Veronika Perz, Klaus Bleymaier, Carsten Sinkel, Ulf Kueper, Melanie Bonnekessel, Doris Ribitsch, Georg M Guebitz
The aliphatic-aromatic copolyester poly(butylene adipate-co-butylene terephthalate) (PBAT), also known as ecoflex, contains adipic acid, 1,4-butanediol and terephthalic acid and is proven to be compostable [1], [2], [3]). We describe here data for the synthesis and analysis of poly(butylene adipate-co-butylene terephthalate variants with different adipic acid:terephatalic acid ratios and 6 oligomeric PBAT model substrates. Data for the synthesis of the following oligomeric model substrates are described: mono(4-hydroxybutyl) terephthalate (BTa), bis(4-(hexanoyloxy)butyl) terephthalate (HaBTaBHa), bis(4-(decanoyloxy)butyl) terephthalate (DaBTaBDa), bis(4-(tetradecanoyloxy)butyl) terephthalate (TdaBTaBTda), bis(4-hydroxyhexyl) terephthalate (HTaH) and bis(4-(benzoyloxy)butyl) terephthalate (BaBTaBBa)...
June 2016: Data in Brief
Sheng-Yang Zhou, Hua-Dong Huang, Xu Ji, Ding-Xiang Yan, Gan-Ji Zhong, Benjamin S Hsiao, Zhong-Ming Li
Remarkable combination of excellent gas barrier performance, high strength, and toughness was realized in polylactide (PLA) composite films by constructing the supernetworks of oriented and pyknotic crystals with the assistance of ductile in situ nanofibrils of poly(butylene adipate-co-terephthalate) (PBAT). On the basis that the permeation of gas molecules through polymer materials with anisotropic structure would be more frustrated, we believe that oriented crystalline textures cooperating with inerratic amorphism can be favorable for the enhancement of gas barrier property...
March 2016: ACS Applied Materials & Interfaces
Veronika Perz, Altijana Hromic, Armin Baumschlager, Georg Steinkellner, Tea Pavkov-Keller, Karl Gruber, Klaus Bleymaier, Sabine Zitzenbacher, Armin Zankel, Claudia Mayrhofer, Carsten Sinkel, Ulf Kueper, Katharina Schlegel, Doris Ribitsch, Georg M Guebitz
Recently, a variety of biodegradable polymers have been developed as alternatives to recalcitrant materials. Although many studies on polyester biodegradability have focused on aerobic environments, there is much less known on biodegradation of polyesters in natural and artificial anaerobic habitats. Consequently, the potential of anaerobic biogas sludge to hydrolyze the synthetic compostable polyester PBAT (poly(butylene adipate-co-butylene terephthalate) was evaluated in this study. On the basis of reverse-phase high-performance liquid chromatography (RP-HPLC) analysis, accumulation of terephthalic acid (Ta) was observed in all anaerobic batches within the first 14 days...
March 15, 2016: Environmental Science & Technology
Bruno V M Rodrigues, Aline S Silva, Gabriela F S Melo, Luana M R Vasconscellos, Fernanda R Marciano, Anderson O Lobo
The use of poly (butylene adipate-co-terephthalate) (PBAT) in tissue engineering, more specifically in bone regeneration, has been underexplored to date due to its poor mechanical resistance. In order to overcome this drawback, this investigation presents an approach into the preparation of electrospun nanocomposite fibers from PBAT and low contents of superhydrophilic multi-walled carbon nanotubes (sMWCNT) (0.1-0.5wt.%) as reinforcing agent. We employed a wide range of characterization techniques to evaluate the properties of the resulting electrospun nanocomposites, including Field Emission Scanning Electronic Microscopy (FE-SEM), Transmission Electronic Microscopy (TEM), tensile tests, contact angle measurements (CA) and biological assays...
February 2016: Materials Science & Engineering. C, Materials for Biological Applications
Veronika Perz, Armin Baumschlager, Klaus Bleymaier, Sabine Zitzenbacher, Altijana Hromic, Georg Steinkellner, Andris Pairitsch, Andrzej Łyskowski, Karl Gruber, Carsten Sinkel, Ulf Küper, Doris Ribitsch, Georg M Guebitz
Two novel esterases from the anaerobe Clostridium botulinum ATCC 3502 (Cbotu_EstA and Cbotu_EstB) were expressed in Escherichia coli BL21-Gold(DE3) and were found to hydrolyze the polyester poly(butylene adipate-co-butylene terephthalate) (PBAT). The active site residues (triad Ser, Asp, His) are present in both enzymes at the same location only with some amino acid variations near the active site at the surrounding of aspartate. Yet, Cbotu_EstA showed higher kcat values on para-nitrophenyl butyrate and para-nitrophenyl acetate and was considerably more active (sixfold) on PBAT...
May 2016: Biotechnology and Bioengineering
Sonia A El Saiedi, Wael A Attia
AIM: Some difficult atrial septal defect (ASD) cases with deficient rims or large defects may require specific maneuvers to facilitate transcatheter occlusion of these defects with self-centering devices. In our center, we developed a modification of balloon-assisted technique (BAT) for difficult ASDs to assist proper positioning of the device. Our aim was to demonstrate the efficiency of ASD closure with self-centering devices in children and to present the results of the new pediatric version of BAT (PBAT) in young children and its relation to the interatrial septal thickness...
November 2015: Journal of Invasive Cardiology
Antonino Biundo, Altijana Hromic, Tea Pavkov-Keller, Karl Gruber, Felice Quartinello, Karolina Haernvall, Veronika Perz, Miriam S Arrell, Manfred Zinn, Doris Ribitsch, Georg M Guebitz
Certain α/β hydrolases have the ability to hydrolyze synthetic polyesters. While their partial hydrolysis has a potential for surface functionalization, complete hydrolysis allows recycling of valuable building blocks. Although knowledge about biodegradation of these materials is important regarding their fate in the environment, it is currently limited to aerobic organisms. A lipase from the anaerobic groundwater organism Pelosinus fermentans DSM 17108(PfL1) was cloned and expressed in Escherichia coli BL21-Gold (DE3) and purified from the cell extract...
February 2016: Applied Microbiology and Biotechnology
Dafu Wei, Hao Wang, Zainab Ziaee, Felipe Chibante, Anna Zheg, Huining Xiao
The antimicrobial thermoplastic starch (ATPS) containing guanidine-based polymers was obtained using a twin-screw extrusion with potato starch and polyhexamethylene guanidine hydrochloride (PHGH). Furthermore, the non-leaching antimicrobial biodegradable poly(butylene adipate-co-terephthalate) (PBAT) was prepared through reactive extrusion with PBAT and ATPS in the presence of the coupling agent, 2,2'-(1,3-phenylene)-bis (2-oxazoline) (PBO). Finally, the antimicrobial PBAT films were obtained by using a blown film extrusion system...
January 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
François Touchaleaume, Lluís Martin-Closas, Hélène Angellier-Coussy, Anne Chevillard, Guy Cesar, Nathalie Gontard, Emmanuelle Gastaldi
In the aim of resolving environmental key issues such as irreversible soil pollution by non-biodegradable and non-recoverable polyethylene (PE) fragments, a full-scale field experiment was set up to evaluate the suitability of four biodegradable materials based on poly(butylene adipate-co-terephtalate) (PBAT) to be used as sustainable alternatives to PE for mulching application in vineyard. Initial ultimate tensile properties, functional properties during field ageing (water vapour permeability and radiometric properties), biodegradability and agronomical performance of the mulched vines (wood production and fruiting yield) were studied...
February 2016: Chemosphere
Dafu Wei, Hao Wang, Huining Xiao, Anna Zheng, Yang Yang
The biodegradable poly(butylene adipate-co-terephthalate)(PBAT)/thermoplastic starch (TPS) composite has received considerable attention because of the environmental concerns raised by solid waste disposal. However, the application of PBAT/TPS blends was limited due to the poor mechanical properties originating from the incompatibility between PBAT and TPS. In this work, two approaches were developed to improve the mechanical properties of PBAT/TPS blends. One approach is to use compatibilizers, including the synthesized reactive compatibilizer - a styrene-maleic anhydride-glycidyl methacrylate (SMG) terpolymer, and the commercial compatibilizer (Joncryl-ADR-4368)...
June 5, 2015: Carbohydrate Polymers
Dibyendu Mondal, Biplab Bhowmick, Dipanwita Maity, Md Masud R Mollick, Dipak Rana, Vivek Rangarajan, Ramkrishna Sen, Dipankar Chattopadhyay
Polymeric nanocomposites embedded with nontoxic antimicrobial agents have recently gained potential industrial significance, mainly for their applicability to preserve food quality and ensure safety. In this study, a poly(butylene adipate-co-terephthalate) (PBAT)/organoclay (CMMT) based nanocomposite film doped with sodium benzoate (SB) as antimicrobial agent was prepared by a solution mixing process. A homogenous dispersion of organoclay (cetyltrimethylammonium-modified montmorillonite [CMMT]) in PBAT matrix was observed by X-ray diffraction and transmission electron microscopy...
March 2015: Journal of Food Science
J B Olivato, J Marini, E Pollet, F Yamashita, M V E Grossmann, L Avérous
The incorporation of nano-sized sepiolite clays into thermoplastic starch/poly(butylene adipate-co-terephthalate) (TPS/PBAT) blends has been investigated with the goal of improving the matrix properties. TPS/PBAT nano-biocomposites were elaborated with two different proportions of the polymeric phases. The influence of the sepiolite nanoclays on the mechanical, thermal and structural properties of the corresponding blends was evaluated. SEM images confirmed the good dispersion of the sepiolite clay, with a low occurrence of small aggregates in the polymeric matrix...
March 15, 2015: Carbohydrate Polymers
Jung-Hung Chen, Ming-Chien Yang
Nanocomposites of poly(butylene adipate-co-terephthalate) (PBAT) with montmorillonite (MMT) nanoparticles were prepared via melt blending. Natural MMT was modified by either octadecylamine (ODA) or dihexylamine (DHA). Neat PBAT was grafted with maleic anhydride via melt grafting process. Intercalation of the organoclay in the PBAT matrix was studied by X-ray diffraction (XRD). From the results of transmission electron microscope (TEM), the dispersion of ODA-modified MMT in the PBAT matrix was more homogeneous than that of neat MMT...
January 2015: Materials Science & Engineering. C, Materials for Biological Applications
Fumihito Miura, Takashi Ito
The current gold standard method for methylome analysis is whole-genome bisulfite sequencing (WGBS), but its cost is substantial, especially for the purpose of multi-sample comparison of large methylomes. Shotgun bisulfite sequencing of target-enriched DNA, or targeted methylome sequencing (TMS), can be a flexible, cost-effective alternative to WGBS. However, the current TMS protocol requires a considerable amount of input DNA and hence is hardly applicable to samples of limited quantity. Here we report a method to overcome this limitation by using post-bisulfite adaptor tagging (PBAT), in which adaptor tagging is conducted after bisulfite treatment to circumvent bisulfite-induced loss of intact sequencing templates, thereby enabling TMS of a 100-fold smaller amount of input DNA with far fewer cycles of polymerase chain reaction than in the current protocol...
February 2015: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
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