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Functional Rehab

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https://www.readbyqxmd.com/read/28832656/involvement-of-insulin-resistance-in-d-galactose-induced-age-related-dementia-in-rats-protective-role-of-metformin-and-saxagliptin
#1
Sara Kenawy, Rehab Hegazy, Azza Hassan, Siham El-Shenawy, Nawal Gomaa, Hala Zaki, Amina Attia
Age-related dementia is one of the most devastating disorders affecting the elderly. Recently, emerging data suggest that impaired insulin signaling is the major contributor in the development of Alzheimer's dementia (AD), which is the most common type of senile dementia. In the present study, we investigated the potential therapeutic effects of metformin (Met) and saxagliptin (Saxa), as insulin sensitizing agents, in a rat model of brain aging and AD using D-galactose (D-gal, 150 mg/kg/day, s.c. for 90 successive days)...
2017: PloS One
https://www.readbyqxmd.com/read/28813696/effects-of-standardized-home-training-in-patients-with-cognitive-impairment-following-geriatric-rehabilitation-a-randomized-controlled-pilot-study
#2
Klaus Hauer, Phoebe Ullrich, Ilona Dutzi, Rainer Beurskens, Sylvia Kern, Jürgen Bauer, Michael Schwenk
BACKGROUND: Post-ward geriatric rehabilitation programs have hardly been developed and validated, which leaves a substantial gap in rehabilitative care in older adults and hinders full exploitation of maintained, but often unrecognized rehabilitation potentials. Geriatric rehabilitation patients with cognitive impairment represent a highly vulnerable population which is often affected by a lack of an ongoing support at the intersection between ward-based and post-ward rehabilitation. OBJECTIVE: To determine the effect of a standardized home-based training program in geriatric patients with cognitive impairment following ward-based rehabilitation...
August 17, 2017: Gerontology
https://www.readbyqxmd.com/read/28771070/efficacy-of-tele-rehabilitation-compared-with-office-based-physical-therapy-in-patients-with-knee-osteoarthritis-a-randomized-clinical-trial
#3
Kamran Azma, Zahra RezaSoltani, Farid Rezaeimoghaddam, Afsaneh Dadarkhah, Sarasadat Mohsenolhosseini
Introduction Knee osteoarthritis is a major cause of disability among the middle to senior age groups. Despite being effective, office-based physical therapy (OBPT) needs professional human resources and is both costly and time-consuming. We aimed to compare the efficacy of tele-rehabilitation (tele-rehab) compared with OBPT in patients with knee osteoarthritis. Methods In this randomized clinical trial, patients with symptomatic osteoarthritis of the knee were assigned to participate in either a 6-week home-based tele-rehab or an OBPT program between 2015 and 2016...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28730332/-a%C3%A2-phase-model-of-trauma-rehabilitation-how-can-we-avoid-the-rehab-hole
#4
Stefan Simmel, Wolf-Dieter Müller, Christoph Reimertz, Christian Kühne, Jean-Jacques Glaesener
Advances in the rescue chain and first aid of polytrauma patients, which have consequently increased their chance of survival, have led to an increase in demands for rehabilitation. However, there is still a large hole in the continuity of rehabilitation between acute patient care and in-patient rehabilitation, the so-called "rehab-hole". The consequences are untapped rehabilitation potential, loss of strength, endurance and motivation as well as impairment of function of the patient.Based on the phase model of neurological/neurosurgical rehabilitation, we propose a step model for the rehabilitation of polytrauma patients that ensures an uninterrupted chain of rehabilitation...
July 20, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28696373/rehabilitation-plus-onabotulinumtoxina-improves-motor-function-over-onabotulinumtoxina-alone-in-post-stroke-upper-limb-spasticity-a-single-blind-randomized-trial
#5
Deidre Devier, JoAnn Harnar, Leandro Lopez, Allison Brashear, Glenn Graham
BACKGROUND: OnabotulinumtoxinA (BoNT-A) can temporarily decrease spasticity following stroke, but whether there is an associated improvement in upper limb function is less clear. This study measured the benefit of adding weekly rehabilitation to a background of BoNT-A treatments for chronic upper limb spasticity following stroke. METHODS: This was a multi-center clinical trial. Thirty-one patients with post-stroke upper limb spasticity were treated with BoNT-A. They were then randomly assigned to 24 weeks of weekly upper limb rehabilitation or no rehabilitation...
July 11, 2017: Toxins
https://www.readbyqxmd.com/read/28638411/regular-dental-visits-influence-on-health-related-quality-of-life-in-1-607-patients-with-oral-squamous-cell-carcinoma
#6
Simon Spalthoff, Henrik Holtmann, Gertrud Krüskemper, Rüdiger Zimmerer, Jörg Handschel, Nils-Claudius Gellrich, Philipp Jehn
BACKGROUND: The incidence of oral squamous cell carcinoma (OSCC) is in the top 10 of all cancer entities. Regular oral examinations by dentists play an important role in oral cancer prevention. METHODS: Patients with OSCC (n = 1,607) and physicians (n = 1,489) completed questionnaires during the DÖSAK Rehab Study. The psychosocial and functional factors collected in these questionnaires were assessed in the present study. We compared patients who visited their dentist at least once a year (group A) with those who visited their dentist less than once a year (group B)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28624037/trauma-care-in-a-multiethnic-population-effects-of-being-undocumented
#7
Jonathan M Wyrick, Brittany A Kalosza, George N Coritsidis, Raymond Tse, George Agriantonis
BACKGROUND: Epidemiologic studies have shown that undocumented immigrants (UIs) display characteristics of having a low socioeconomic status and are primarily of ethnic minorities. These social determinants of health are known to be associated with diminished health care access and poor clinical outcomes. We therefore investigated the impact of documentation status on the clinical outcomes of patients with traumatic injuries. MATERIALS AND METHODS: We conducted a retrospective review of the trauma registry at our safety net institution for all adult patients who were admitted from 2010 to 2014...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28561453/the-impact-of-developing-a-speech-and-swallow-rehab-program-improving-patient-satisfaction-and-multidisciplinary-care
#8
Heather M Starmer, Noel Ayoub, Cynthia Byward, Jennifer Kizner, Quynh Le, Wendy Hara, F Christopher Holsinger
OBJECTIVES/HYPOTHESIS: The objective of this study was to evaluate the impact of developing an integrated head and neck cancer speech and swallowing rehabilitation program on physician/team focus on functional outcomes. STUDY DESIGN: Prospective cross-sectional design. METHODS: Surveys regarding physician behavior and patient satisfaction with speech and swallowing were administered in an academic oncology practice prior to and 1 year following establishment of a dedicated head and neck speech and swallowing rehabilitation program...
May 31, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28552824/functional-recovery-following-early-mobilization-after-middle-third-clavicle-osteosynthesis-for-acute-fractures-or-nonunion-a-case-control-study
#9
A Lädermann, S Abrassart, P J Denard, J Tirefort, A Nowak, A J Schwitzguebel
BACKGROUND: Good outcomes have been reported after surgical treatment for acute or nonunion of displaced midshaft clavicle fractures. However, the postoperative rehabilitation and timeline for a complete functional recovery are poorly documented. The purpose of the current study was to evaluate the efficacy of an immediate motion protocol following plate fixation of a midshaft clavicle fracture and to compare functional recovery between acute and nonunion cases. METHODS: Between October 2011 and July 2015, all patients above the age of 18, having either an acute or a nonunion of the midshaft clavicle fracture, were considered as potentially eligible for inclusion in this prospective case-control study...
May 25, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28520624/cardiac-rehabilitation-outcomes-by-ethnocultural-background-results-from-the-canadian-cardiac-rehab-registry
#10
Briar Findlay, Paul Oh, Sherry L Grace
BACKGROUND: Patients of diverse ethnocultural backgrounds are underrepresented among participants and, hence, little is known about their outcomes. The objectives of this study were to compare cardiac rehabilitation (CR) utilization, cardiovascular risk factor reduction (blood pressure, lipids, anthropometrics), and functional capacity between white and ethnocultural minority patients participating in CR across Canada. METHODS: The study was a retrospective, observational cohort study using the Canadian Cardiac Rehab Registry (CCRR)...
September 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28428892/a-comparison-of-earlier-and-enhanced-rehabilitation-of-mechanically-ventilated-patients-in-critical-care-compared-to-standard-care-rehab-study-protocol-for-a-single-site-randomised-controlled-feasibility-trial
#11
Catherine Snelson, Charlotte Jones, Gemma Atkins, James Hodson, Tony Whitehouse, Tonny Veenith, David Thickett, Emma Reeves, Aisling McLaughlin, Lauren Cooper, David McWilliams
BACKGROUND: Mortality from critical illness is improving, but survivors suffer from prolonged weakness and psychological and cognitive impairments. Maximising the recovery after critical illness has been highlighted as a research priority, especially in relation to an ageing population who present with higher rates of pre-morbid disability. Small studies have shown that starting rehabilitation early within the intensive care unit (ICU) improves short-term outcomes. Systematic reviews have highlighted the need for robust multicentre randomised controlled trials with longer term follow-up...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28427091/-development-and-evaluation-of-herzwegweiser-de-an-informational-website-designed-for-post-rehabilitation-support-of-cardiac-patients-and-their-healthcare-professionals-in-berlin-brandenburg
#12
Sabine Stamm-Balderjahn, Susanne Bartel, Kristin Wilke, Karla Spyra
ObjectiveThe internet portal 'herzwegweiser.de' was developed to assist individuals with cardiovascular diseases in the phase III rehabilitation in the region of Berlin-Brandenburg. It provides information on this specific disease as well as on aftercare services, e. g. regional cardiac groups. For the medical and therapeutic colleagues specific information such as treatment guidelines and a cardiac group placement service for trainers and medical doctors were set up. MethodsThe study was based on a mixed-methods design...
April 20, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/28419206/short-term-preoperative-exercise-therapy-does-not-improve-long-term-outcome-after-lung-cancer-surgery-a-randomized-controlled-study
#13
Wolfram Karenovics, Marc Licker, Christoph Ellenberger, Michel Christodoulou, John Diaper, Chetna Bhatia, John Robert, Pierre-Olivier Bridevaux, Frédéric Triponez
OBJECTIVES: Poor aerobic fitness is a potential modifiable risk factor for long-term survival and quality of life in patients with lung cancer. This randomized trial evaluates the impact of adding rehabilitation (Rehab) with high-intensity interval training (HIIT) before lung cancer surgery to enhance cardiorespiratory fitness and improve long-term postoperative outcome. METHODS: Patients with operable lung cancer were randomly assigned to usual care (UC, n  = 77) or to intervention group (Rehab, n  = 74) that entailed HIIT that was implemented only preoperatively...
July 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28382499/sitagliptin-exerts-anti-apoptotic-effect-in-nephrotoxicity-induced-by-cisplatin-in-rats
#14
Rehab S Abdelrahman
Sitagliptin is a selective inhibitor of dipeptidylpeptidase-4 enzyme used for the management of diabetes mellitus type II. The anti-inflammatory, antioxidant, and anti-apoptotic properties of sitagliptin were documented. This study was designed to explore the effect of sitagliptin (10 mg/kg, orally) on nephrotoxicity induced by cisplatin (7 mg/kg, i.p.) in Sprague-Dawley rats. Nephrotoxicity of cisplatin was manifested by elevation in renal somatic index, proteinuria, blood urea nitrogen, creatinine in serum, lactate dehydrogenase, kidney malondialdehyde, NF-κB, Bax, and annexin V...
July 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28317527/phototherapy-and-combination-therapies-for-vitiligo
#15
REVIEW
Samia Esmat, Rehab A Hegazy, Suzan Shalaby, Stephen Chu-Sung Hu, Cheng-Che E Lan
Vitiligo is a disease characterized by disappearance of melanocytes from the skin. It can negatively influence the physical appearance of affected individuals, and may profoundly affect a person's psychosocial function and quality of life. Therefore, vitiligo should not be considered as merely a condition that affects a patient's appearance, but needs to be actively treated in patients who seek medical help. Phototherapy has been used as the main treatment modality for patients with vitiligo. Different forms of phototherapy for vitiligo include broadband UVB, narrowband UVB, excimer light and excimer laser, and psoralen plus UVA...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28285121/a-novel-rehabilitation-intervention-for%C3%A2-older-patients-with-acute%C3%A2-decompensated%C3%A2-heart-failure-the-rehab-hf-pilot-study
#16
Gordon R Reeves, David J Whellan, Christopher M O'Connor, Pamela Duncan, Joel D Eggebeen, Timothy M Morgan, Leigh Ann Hewston, Amy Pastva, Mahesh J Patel, Dalane W Kitzman
OBJECTIVES: This study sought to assess a novel physical rehabilitation intervention in older patients hospitalized for acute decompensated heart failure (ADHF). BACKGROUND: After ADHF, older patients, who are frequently frail with multiple comorbidities, have prolonged and incomplete recovery of physical function and remain at high risk for poor outcomes. METHODS: The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) pilot study was a 3-site, randomized, attention-controlled pilot study of a tailored, progressive, multidomain physical rehabilitation intervention beginning in the hospital and continuing for 12 weeks post-discharge in patients ≥60 years hospitalized with ADHF...
May 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28279729/access-to-posthospitalization-acute-care-facilities-is-associated-with-payer-status-for-open-abdominal-aortic-repair-and-open-lower-extremity-revascularization-in-the-vascular-quality-initiative
#17
Jesus G Ulloa, Karen Woo, Chi-Hong Tseng, Melinda Maggard-Gibbons, David Rigberg
BACKGROUND: Uninsured patients may not have access to postacute care facilities that play an important role in clinical recovery, and functional outcomes after vascular surgery. We sought to determine whether discharge disposition is associated with insurance status. METHODS: We retrospectively reviewed data from the Vascular Quality Initiative(®) for patients who underwent open abdominal aortic repair, infrainguinal bypass, or suprainguinal bypass (SB) between January 2012 and July 2015...
March 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28267466/rehabilitation-therapy-in-older-acute-heart-failure-patients-rehab-hf-trial-design-and-rationale
#18
RANDOMIZED CONTROLLED TRIAL
Gordon R Reeves, David J Whellan, Pamela Duncan, Christopher M O'Connor, Amy M Pastva, Joel D Eggebeen, Leigh Ann Hewston, Timothy M Morgan, Shelby D Reed, W Jack Rejeski, Robert J Mentz, Paul B Rosenberg, Dalane W Kitzman
BACKGROUND: Acute decompensated heart failure (ADHF) is a leading cause of hospitalization in older persons in the United States. Reduced physical function and frailty are major determinants of adverse outcomes in older patients with hospitalized ADHF. However, these are not addressed by current heart failure (HF) management strategies and there has been little study of exercise training in older, frail HF patients with recent ADHF. HYPOTHESIS: Targeting physical frailty with a multi-domain structured physical rehabilitation intervention will improve physical function and reduce adverse outcomes among older patients experiencing a HF hospitalization...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28266775/bone-marrow-derived-mesenchymal-stem-cells-mitigate-caspase-3-and-8-hydroxy-proline-induced-via-%C3%AE-adrenergic-agonist-in-pulmonary-injured-rats
#19
Mai O Kadry, Rehab M Abdel-Megeed
Estimating the ability of bone marrow-derived mesenchymal stem cells (BM-MSCs) to alleviate pulmonary injury induced via isoproterenol (ISP). ISP was injected in a dose of (100 mg/kg, subcutaneously twice at an interval of 24 h). One month post BM-MSCs transplantation by intravenous injection, pulmonary oxidative stress was assessed, and Western blot analyses and histopathological investigations were conducted. Compared with the normal control group, BM-MSCs transplantation significantly decreased the expression of pulmonary anti-oxidative stress marker...
August 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28177688/hepato-and-neuro-protective-influences-of-biopropolis-on-thioacetamide-induced-acute-hepatic-encephalopathy-in-rats
#20
Rasha E Mostafa, Abeer A A Salama, Rehab F Abdel-Rahman, Hanan A Ogaly
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that ultimately occurs as a complication of acute or chronic liver failure; accompanied by hyperammonemia. This study aimed to evaluate the potential of biopropolis as a hepato- and neuro-protective agent using thioacetamide (TAA)-induced acute HE in rats as a model. Sixty Wistar rats were divided into 5 groups: Group 1 (normal control) received only saline and paraffin oil. Group 2 (hepatotoxic control) received TAA (300 mg/kg, once). Groups 3, 4, and 5 received TAA followed by vitamin E (100 mg/kg) and biopropolis (100 and 200 mg/kg), respectively, daily for 30 days...
May 2017: Canadian Journal of Physiology and Pharmacology
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