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https://www.readbyqxmd.com/read/29774765/-staying-safe-a-narrative-review-of-falls-prevention-in-people-with-parkinson-s-pdsafe
#1
Sophia Hulbert, Lynn Rochester, Alice Nieuwboer, Vicki Goodwin, Carolyn Fitton, Kim Chivers-Seymour, Ann Ashburn
BACKGROUND: Parkinson's disease demonstrates a spectrum of motor and non-motor symptoms. Falling is common and disabling. Current medical management shows minimal impact to reduce falls or fall-related risk factors, such as deficits in gait, strength, and postural instability. Despite evidence supporting rehabilitation in reducing fall risk factors, the most appropriate intervention to reduce overall fall rate remains inconclusive. This article aims to 1) synthesise current evidence and conceptual models of falls rehabilitation in Parkinson's in a narrative review; and based on this evidence, 2) introduce the treatment protocol used in the falls prevention and multi-centre clinical trial "PDSAFE"...
May 18, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29739371/effectiveness-of-three-interventions-for-secondary-prevention-of-low-back-pain-in-the-occupational-health-setting-a-randomised-controlled-trial-with-a-natural-course-control
#2
J Rantonen, J Karppinen, A Vehtari, S Luoto, E Viikari-Juntura, M Hupli, A Malmivaara, S Taimela
BACKGROUND: We assessed the effectiveness of three interventions that were aimed to reduce non-acute low back pain (LBP) related symptoms in the occupational health setting. METHODS: Based on a survey (n = 2480; response rate 71%) on LBP, we selected a cohort of 193 employees who reported moderate LBP (Visual Analogue Scale VAS > 34 mm) and fulfilled at least one of the following criteria during the past 12 months: sciatica, recurrence of LBP ≥ 2 times, LBP ≥ 2 weeks, or previous sickness absence...
May 8, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29721912/a-middle-eastern-founder-mutation-expands-the-genotypic-and-phenotypic-spectrum-of-mitochondrial-micu1-deficiency-a-report-of-13-patients
#3
Sara Musa, Wafaa Eyaid, Kimberli Kamer, Rehab Ali, Mariam Al-Mureikhi, Noora Shahbeck, Fatma Al Mesaifri, Nawal Makhseed, Zakkiriah Mohamed, Wafaa Ali AlShehhi, Vamsi K Mootha, Jane Juusola, Tawfeg Ben-Omran
MICU1 encodes a Ca2+ sensing, regulatory subunit of the mitochondrial uniporter, a selective calcium channel within the organelle's inner membrane. Ca2+ entry into mitochondria helps to buffer cytosolic Ca2+ transients and also activates ATP production within the organelle. Mutations in MICU1 have previously been reported in 17 children from nine families with muscle weakness, fatigue, normal lactate, and persistently elevated creatine kinase, as well as variable features that include progressive extrapyramidal signs, learning disabilities, nystagmus, and cataracts...
May 3, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29668338/morphometric-and-ultrastructural-analysis-of-tramadol-effects-on-epididymis-an-experimental-study
#4
Abdalla Mohamed Attia, Ola Ahmed Bakry, Hossam Yassin, Naglaa Sarhan, Rehab Samaka, Nahla Gamal
The effect of tramadol addiction on epididymal structure was not investigated before. Therefore, this experimental study was carried out to investigate the effect of chronic tramadol use on the epididymal structure using light and electron microscopies. Thirty adult Wister Albino male rats were divided into two groups: control group (five rats) and tramadol-treated group (25 rats), which was further subdivided into five subgroups that received tramadol orally at 4.5, 9, 45, 90, and 135 mg/kg/day, respectively, for 18 weeks...
April 18, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29660970/inflammation-and-rehabilitation-outcomes-in-patients-with-nontraumatic-intracranial-haemorrhage
#5
Mirella Boselli, Roberto Aquilani, Roberto Maestri, Maria Pia Achilli, Nadia Arrigoni, Evasio Pasini, Anna Maria Condino, Federica Boschi, Maurizia Dossena, Daniela Buonocore, Manuela Verri
BACKGROUND: Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS: We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP and or interleukine-6, IL-6) to establish their impact on functional status (Functional Independence Measure, FIM: 18 indicating the worst performance and 126, a normal score)...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29655678/anti-inflammatory-and-antioxidant-activities-of-naringin-isolated-from-carissa-carandas-l-in-vitro-and-in-vivo-evidence
#6
Ahmed H El-Desoky, Rehab F Abdel-Rahman, Osama K Ahmed, Hossam S El-Beltagi, Masao Hattori
BACKGROUND: Carissa carandas L. is known in folk medicine for its anti-inflammatory and hepatoprotective activities. Meanwhile it is an evergreen shrub that constitutes a continuous source of leaves throughout the year. HYPOTHESIS/PURPOSE: The leaves of Carissa carandas L. may be rich in compounds that can be used as safe anti-inflammatory and antioxidant remedies. The combined antioxidant and anti-inflammatory activities provoked the study of the hepatoprotective effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29649611/predictors-of-adverse-discharge-disposition-in-adult-spinal-deformity-and-associated-costs
#7
Peter G Passias, Gregory W Poorman, Cole A Bortz, Rabia Qureshi, Bassel G Diebo, Justin C Paul, Samantha R Horn, Frank A Segreto, Alexandra Pyne, Cyrus M Jalai, Virginie Lafage, Shay Bess, Frank J Schwab, Hamid Hassanzadeh
BACKGROUND CONTEXT: With advances in the understanding of adult spinal deformity (ASD), more complex osteotomy and fusion techniques are being implemented with increasing frequency. Patients undergoing ASD corrections infrequently require extended acute care, longer inpatient stays, and are discharged to supervised care. Given the necessity of value-based health care, identification of clinical indicators for adverse discharge disposition in ASD surgeries is paramount. PURPOSE: On nationwide and surgeon-created databases, identify predictors of adverse discharge disposition after ASD surgeries and view corresponding differences in charges...
April 9, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29617006/relevance-of-b-lines-on-lung-ultrasound-in-volume-overload-and-pulmonary-congestion-clinical-correlations-and-outcomes-in-patients-on-hemodialysis
#8
Marc M Saad, Jeanne Kamal, Elias Moussaly, Boutros Karam, Wissam Mansour, Emad Gobran, Saqib Hussen Abbasi, Ahmed Mahgoub, Puja Singh, Ross Hardy, Devjani Das, Cara Brown, Monica Kapoor, Seleshi Demissie, Morton J Kleiner, Elie El Charabaty, Suzanne E El Sayegh
BACKGROUND: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes. METHODS: End-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29556126/modulation-of-cyp450-als1-and-cox-2-signaling-pathways-induced-by-candida-albicans-infection-via-novel-antifungal-agents
#9
Rehab M Abdel Megeed, Dalia B Fayed, Amira Abood, Mai O Kadry
Although, fluconazole is widely used in clinical treatment as an antifungal drug, it recorded potential problems as resistance and intracellular accumulation. Female albino mice were injected with single ip dose of Candida albicans (1.5 × 106 CFU) . Three weeks post treatment with fluconazole and two novel synthesized compounds [(2-(4-(Pyridin-2-yl) aminosulfonylphenylamino)-6-(naphthalen-2-yl)-4-(pyridin-2-yl) pyridine-3carbonitrile) and (2-(4-(Pyrimidin-2-yl) aminosulfonylphenylamino)-6-(naphthalen-2-yl)-4-(pyridine-2-yl)pyridine-3-carbonitrile) (13b & 14b, respectively)] in both low and high doses (50 mg/kg & 200 mg/kg), liver function and vaginal inflammation were assessed...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29452233/role-of-adipose-tissue-derived-stem-cells-differentiated-into-insulin-producing-cells-in-the-treatment-of-type-i-diabetes-mellitus
#10
Mona G Amer, Azza S Embaby, Rehab A Karam, Marwa G Amer
Generation of new β cells is an important approach in the treatment of type 1 diabetes mellitus (type 1 DM). Adipose tissue-derived stem cells (ADSCs) might be one of the best sources for cell replacement therapy for diabetes. Therefore, this work aimed to test the possible role of transplanted insulin-producing cells (IPCs) differentiated from ADSCs in treatment of streptozotocin (STZ) induced type I DM in rats. Type 1 DM was induced by single intra peritoneal injection with STZ (50 mg/kg BW). Half of the diabetic rats were left without treatment and the other half were injected with differentiated IPCs directly into the pancreas...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29427035/probiotics-as-a-complementary-therapy-in-the-model-of-cadmium-chloride-toxicity-crosstalk-of-%C3%AE-catenin-bdnf-and-star-signaling-pathways
#11
Mai O Kadry, Rehab Abdel Megeed
Cadmium chloride (CdCl2 ) is a ubiquitous environmental toxicant that causes a variety of disturbances in biological systems, including brain dysfunction and testicular tissue degeneration. On the other hand, it is supposed that beneficial properties of probiotic bacteria (Lactobacillus and Acidobacillus) are related to their capacity to adhere or bind different targets, thus leading to improved intestinal microbial balance and other benefits to the host. Bearing aforementioned in mind, the present study was undertaken to investigate the protective effect of probiotic supplementation against cadmium chloride-induced brain and testis toxicity in mice model...
February 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29424355/cytotoxicity-of-propolis-nanopreparations-in-cancer-cell-monolayers-multimode-of-action-including-apoptotsis-and-nitric-oxide-production
#12
Mahmoud S Sherif, Taha A Rehab, Zayed A Hamdia, Vladmir P Torchilin
Natural products are invaluable resource of anticancer drug discovery. They generally viewed as safe but weak, within the framework of nanotechnology, they can serve as template for potent anticancer drugs. We first evaluated the cytotoxic activity of different propolis extracts (water, 70% ethanol, absolute ethanol and hexane) in many cancer cell lines, then the solid nanoparticles from the organic solvent extracts were prepared and their cytotoxicity was evaluated as well. Finally, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes were prepared from the most cytotoxic organic solvent extract and their cytotoxicity was also evaluated...
January 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29400686/prehab-vs-rehab-presurgical-treatment-in-vestibular-schwannoma-surgery-enhances-recovery-of-postural-control-better-than-postoperative-rehabilitation-retrospective-case-series
#13
Fredrik Tjernström, Per-Anders Fransson, Babar Kahlon, Mikael Karlberg, Sven Lindberg, Peter Siesjö, Måns Magnusson
OBJECT: To evaluate post-surgical postural stability when treating patients with remaining vestibular function with intratympanic gentamicin (PREHAB) prior to schwannoma surgery. METHOD: 44 consecutive patients with some form remaining vestibular function scheduled for vestibular schwannoma surgery. 20 were medically deafferented with intratympanic gentamicin before surgery and 24 were not. Both groups were of the same age, had the same tumor size, same type of surgery, and same perioperative sensory rehabilitation (training exercises), and no surgical complications...
2018: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29391361/effect-of-spinal-orthoses-and-postural-taping-on-balance-gait-and-quality-of-life-in-older-people-with-thoracic-hyperkyphosis-protocol-for-a-systematic-review-and-meta-analysis
#14
Atefeh Aboutorabi, Mokhtar Arazpour, Monireh Ahmadi Bani, Abbas Ali Keshtkar
INTRODUCTION: Thoracic hyperkyphosis is one of the most common spinal disorders in older people, creating impairment, postural instability, gait disorders and a reduced quality of life. The use of spinal orthoses and/or postural taping may be feasible conservative interventions, but their efficacy is uncertain. The aim of this review is therefore to investigate the effectiveness of spinal orthoses and taping on the balance and gait of older people with hyperkyphosis. METHODS AND ANALYSIS: We will include randomised controlled trials and clinical trial studies which assess the efficacy of spinal orthoses and taping using the WHO International Classification of Functioning, Disability and Health (ICF) outcome measures in older people with hyperkyphosis of the thoracic spine...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29366868/in-vivo-assessment-of-the-hepatotoxicity-of-a-new-nostoc-isolate-from-the-nile-river-nostoc-sp-strain-nri
#15
Marwa M Abu-Serie, Nermine Nasser, Abeer Abd El-Wahab, Rehab Shehawy, Harrison Pienaar, Nahed Baddour, Ranya Amer
Nostoc sp. is one of the most widely distributed cyanobacterial genera that produce potentially protein phosphatase (PP) inhibitor; microcystins (MCs). MCs have posed a worldwide concern due to predominant hepatotoxicity to human health. We have previously isolated a Nostoc strain (NR1) from the Nile River (the main water supply in Egypt) and this strain exerted production of rare and highly toxic MC; demethylated microcystin-LR. There is no data concerning risk factors of liver diseases for human and animal exposure to NR1-contaminated drinking water yet...
March 1, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29352683/discharge-to-inpatient-rehab-does-not-result-in-improved-functional-outcomes-following-primary-total-knee-arthroplasty
#16
Douglas E Padgett, Alexander B Christ, Amethia D Joseph, You-Yu Lee, Steven B Haas, Stephen Lyman
BACKGROUND: Monitored rehabilitation has long been considered an essential part of the recovery process in total knee arthroplasty (TKA). However, the optimal setting for rehabilitation remains uncertain. We sought to determine whether inpatient rehabilitation settings result in improved functional and patient-reported outcomes after primary TKA. METHODS: All patients undergoing primary TKA from May 2007 to February 2011 were identified from our institutional total joint registry...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29327644/evaluation-of-supervised-multimodal-prehabilitation-programme-in-cancer-patients-undergoing-colorectal-resection-a-randomized-control-trial
#17
Guillaume Bousquet-Dion, Rashami Awasthi, Sarah-Ève Loiselle, Enrico M Minnella, Ramanakumar V Agnihotram, Andreas Bergdahl, Francesco Carli, Celena Scheede-Bergdahl
BACKGROUND: Prehabilitation has been previously shown to be more effective in enhancing postoperative functional capacity than rehabilitation alone. The purpose of this study was to determine whether a weekly supervised exercise session could provide further benefit to our current prehabilition program, when comparing to standard post-surgical rehabilitation. METHODS: A parallel-arm single-blind randomized control trial was conducted in patients scheduled for non-metastatic colorectal cancer resection...
January 12, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29326488/resveratrol-prevents-liver-fibrosis-via-two-possible-pathways-modulation-of-alpha-fetoprotein-transcriptional-levels-and-normalization-of-protein-kinase-c-responses
#18
Alyaa Farouk Hessin, Rehab Rehab Hegazy, Azza Ahmed Hassan, Nemat Zakaria Yassin, Sanaa Abdel-Baky Kenawy
OBJECTIVE: Liver fibrosis is a global health problem that causes approximately 1.4 million deaths per year. It is associated with inflammation, oxidative stress, necrosis and ends with cirrhosis, liver cancer, or liver failure. Therefore, the present study was constructed to investigate the protective effect of resveratrol (RVT) on liver fibrosis, focusing on the possible involvement of alpha 1-fetoprotein and protein kinase C signaling. MATERIALS AND METHODS: Rats received thioacetamide (TAA) (200 mg/kg, intraperitoneal) twice weekly, for 4 successive weeks to induce liver fibrosis...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29301410/factors-influencing-the-potency-of-alzheimer-inhibitors-computational-and-docking-studies
#19
Faten Atlam, Mohamed Awad, Rehab Salama
Density functional theory (B3LYP/6-31G [d]) is performed to study the effect of molecular and electronic structures of the investigated β-secretase 1 (BACE1) Alzheimer's inhibitors on their biological activities and discuss the correlation between their inhibition efficiencies and quantum chemical descriptors. IC50 values of the investigated compounds are mostly affected by the substituted R2 phenyl moiety. The calculations show that the presence of electron withdrawing group increases the half maximal inhibitory concentration (IC50 )...
May 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29218260/a-case-of-streptococcus-anginosus-brain-abscess-caused-by-contiguous-spread-from-sinusitis-in-an-immunocompetent-patient
#20
Nathan Esplin, John W Stelzer, Sean All, Sundeep Kumar, Ejaz Ghaffar, Sayed Ali
Brain abscesses are infections of the brain parenchyma that can arise from either contiguous spread from local infection or by hematogenous spread from a distant site. Streptococcus anginosus of the Streptococcus anginosus group (SAG) is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract. We present a case of mono-microbial brain abscess caused by contiguous spread from relatively asymptomatic sinusitis that initially presented as a subdural hemorrhage on computed tomography...
October 4, 2017: Curēus
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