Read by QxMD icon Read

rodriguez bosch

Rosa M Pintó, Francisco-Javier Pérez-Rodríguez, Lucia D' Andrea, Montserrat de Castellarnau, Susana Guix, Albert Bosch
Codon usage bias is universal to all genomes. Hepatitis A virus (HAV) codon usage is highly biased and deoptimized with respect to its host. Accordingly, HAV is unable to induce cellular translational shutoff and its internal ribosome entry site (IRES) is inefficient. Codon usage deoptimization may be seen as a hawk (host cell) versus dove (HAV) game strategy for accessing transfer RNA (tRNA). HAV avoids use of abundant host cell codons and thereby eludes competition for the corresponding tRNAs. Instead, codons that are abundant or rare in cellular messenger RNAs (mRNAs) are used relatively rarely in its genome, although intermediately abundant host cell codons are abundant in the viral genome...
March 12, 2018: Cold Spring Harbor Perspectives in Medicine
Manuel A Gomez-Marcos, Maria C Patino-Alonso, Jose I Recio-Rodriguez, Cristina Agudo-Conde, Montserrat Romaguera-Bosch, Olga Magdalena-Gonzalez, Amparo Gomez-Arranz, Nere Mendizabal-Gallastegui, Jose Angel Fernandez-Diez, Leticia Gomez-Sanchez, Jose A Maderuelo-Fernandez, Emiliano Rodriguez-Sanchez, Luis Garcia-Ortiz
BACKGROUND: Evidence on the efficacy of smartphone applications (apps) for reducing body weight and other measurements of adiposity sustainably is not conclusive. OBJECTIVE: To evaluate the effect of adding an app for 3 months to traditional counselling on physical activity (PA) and a heart-healthy diet for the modification of measurements of adiposity at 3 and 12 months after intervention. METHODS: This randomised clinical trial included 833 subjects...
February 1, 2018: European Journal of Cardiovascular Nursing
Dolors Bosch, Marcela A Rodríguez, Laura Depalo, Jesús Avilla
The codling moth, Cydia pomonella (L.) (Lepidoptera: Tortricidae), is the key pest on pome fruit and walnut orchards worldwide. Its resistance to available insecticides has been widely reported. Chlorantraniliprole is an anthranilic diamide that was introduced in European countries in 2008-2009 and acts by activating the insect's ryanodine receptors. The aims of this study were to determine the baseline susceptibility of European populations of C. pomonella to chlorantraniliprole, to establish the discriminant concentrations (DC) to check the possible development of resistance, and to know the role of cytochrome P450 monooxygenases (P450) in the possible susceptibility decrease of field populations to the insecticide...
February 9, 2018: Journal of Economic Entomology
Elena Martín-Hernández, María Elena Rodríguez-García, Chun-An Chen, Francisco Javier Cotrina-Vinagre, Patricia Carnicero-Rodríguez, Marcello Bellusci, Christian P Schaaf, Francisco Martínez-Azorín
We report the clinical and biochemical findings from a patient who presented with Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS), an autosomal-dominant disorder characterized by optic atrophy, developmental delay and intellectual disability. In addition, the patient also displays hypotonia, stroke-like episodes, and complex IV deficiency of the mitochondrial respiratory chain. Whole-exome sequencing (WES) uncovered a novel heterozygous mutation in the NR2F1 gene (NM_005654:c.286A>G:p.Lys96Glu) that encodes for the COUP transcription factor 1 protein (COUP-TF1)...
February 6, 2018: Journal of Human Genetics
Vicente Aldasoro Cáceres, Rosario Ibáñez Bosch, Nathalí Rivas Zavaleta, Belén Álvarez Rodríguez, Juan José Intxausti Irazábal, Juan Ramón de Dios Jiménez de Aberasturi, Ana Ruibal Escribano, Olga Maíz Alonso, Jaime Calvo Alén
OBJECTIVES: Describe patients with noninfectious aortitis and their response to treatment in a regional hospital. METHODS: Review of patients with noninfectious aortitis, diagnostic technique used and immunosuppressive therapy received. RESULTS: We report 8 patients (7 women and one man) diagnosed with aortitis by positron emission tomography (PET). The mean age was 69years (interquartile range [IQR] 62-72.2). Three months of treatment with tocilizumab improved symptoms, erythrocyte sedimentation rate and C-reactive protein level (P<...
February 1, 2018: Reumatología Clinica
David Romeo-Guitart, Joaquim Forés, Mireia Herrando-Grabulosa, Raquel Valls, Tatiana Leiva-Rodríguez, Elena Galea, Francisco González-Pérez, Xavier Navarro, Valerie Petegnief, Assumpció Bosch, Mireia Coma, José Manuel Mas, Caty Casas
Here we used a systems biology approach and artificial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. Unbiased proteomic data from our preclinical models were used for machine learning algorithms and for restrictions to be imposed on mathematical solutions...
January 30, 2018: Scientific Reports
Dolors Bosch, Marcela A Rodríguez, Jesús Avilla
BACKGROUND: A widespread resistance of Cydia pomonella to organophosphates was demonstrated in populations from the Spanish Ebro Valley area that showed high levels of enzymatic detoxification. To determine the efficacy of new insecticides, neonate larvae bioassays were carried out on twenty field codling moth populations collected from three different Spanish apple production areas. Synergist bioassays were performed to detect the enzymatic mechanisms involved. RESULTS: The least active ingredients were methoxyfenozide, with 100% of the populations showing significantly lower mortality than the susceptible strain, and lambda-cyhalothrin, with very high resistant ratios (872...
November 16, 2017: Pest Management Science
Guillem Caldentey, Pablo García De Frutos, Helena Cristóbal, Manel Garabito, Antonio Berruezo, Xavier Bosch, Rodolfo San Antonio, Eduardo Flores-Umanzor, Rosario J Perea, Teresa M De Caralt, Jany Rodríguez, José T Ortiz-Pérez
BACKGROUND: Serum soluble AXL (sAXL) and its ligand, Growth Arrest-Specific 6 protein (GAS6), intervene in tissue repair processes. AXL is increased in end-stage heart failure, but the role of GAS6 and sAXL in ST-segment elevation myocardial infarction (STEMI) is unknown. OBJECTIVES: To study the association of sAXL and GAS6 acutely and six months following STEMI with heart failure and left ventricular remodelling. METHODS: GAS6 and sAXL were measured by enzyme-linked immunosorbent assay at one day, seven days and six months in 227 STEMI patients and 20 controls...
November 1, 2017: European Heart Journal. Acute Cardiovascular Care
Adriano Rodríguez-Trujillo, José Ríos, Martina A Ángeles, David E Posadas, Clara Murillo, Claudia Rueda, Francesc Botet, Jordi Bosch, Andrea Vergara, Eduard Gratacós, Montse Palacio, Teresa Cobo
OBJECTIVE: To evaluate the influence of perinatal inflammation on neurodevelopmental outcome of premature infants. STUDY DESIGN: From a retrospective cohort study of women with preterm labor with intact membranes or preterm prelabor rupture of membranes (PPROM) with an amniocentesis to rule out intra-amniotic inflammation (IAI) and microbial invasion of the amniotic cavity (MIAC), we evaluated neurodevelopmental outcome of their infants born between 24.0 and 34...
November 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
Clément François, Maria Teixidó, Sylvain Takerkart, Thaïs Agut, Laura Bosch, Antoni Rodriguez-Fornells
Words and melodies are some of the basic elements infants are able to extract early in life from the auditory input. Whether melodic cues contained in songs can facilitate word-form extraction immediately after birth remained unexplored. Here, we provided converging neural and computational evidence of the early benefit of melodies for language acquisition. Twenty-eight neonates were tested on their ability to extract word-forms from continuous flows of sung and spoken syllabic sequences. We found different brain dynamics for sung and spoken streams and observed successful detection of word-form violations in the sung condition only...
September 29, 2017: Scientific Reports
David Gallardo, Anna Bosch-Vizcaya, Rocío Rodríguez-Romanos, Nazly Santos, Ismael Buño, Rafael de la Cámara, Salut Brunet, Antonio Jiménez-Velasco, Marcos González, Jose B Nieto, Carolina Martínez-Laperche, Carlos Vallejo, Christelle Ferrá, Antònia Sampol, Javier López-Jiménez, Jose A Pérez-Simón, Carmen Martínez, Jose L Díez
Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor...
December 2017: Biology of Blood and Marrow Transplantation
Paula L Monteagudo, Anna Lacasta, Elisabeth López, Laia Bosch, Javier Collado, Sonia Pina-Pedrero, Florencia Correa-Fiz, Francesc Accensi, María Jesús Navas, Enric Vidal, María J Bustos, Javier M Rodríguez, Andreas Gallei, Veljko Nikolin, María L Salas, Fernando Rodríguez
African swine fever is a highly contagious viral disease of mandatory declaration to the World Organization for Animal Health (OIE). The lack of available vaccines makes its control difficult; thus, African swine fever virus (ASFV) represents a major threat to the swine industry. Inactivated vaccines do not confer solid protection against ASFV. Conversely, live attenuated viruses (LAV), either naturally isolated or obtained by genetic manipulation, have demonstrated reliable protection against homologous ASFV strains, although little or no protection has been demonstrated against heterologous viruses...
November 1, 2017: Journal of Virology
Juan Antonio Rodríguez, Urko M Marigorta, David A Hughes, Nino Spataro, Elena Bosch, Arcadi Navarro
Senescence has long been a public health challenge as well as a fascinating evolutionary problem. There is neither a universally accepted theory for its ultimate causes, nor a consensus about what may be its impact on human health. Here we test the predictions of two evolutionary explanations of senescence-mutation accumulation and antagonistic pleiotropy-which postulate that genetic variants with harmful effects in old ages can be tolerated, or even favoured, by natural selection at early ages. Using data from genome-wide association studies (GWAS), we study the effects of genetic variants associated with diseases appearing at different periods in life, when they are expected to have different impacts on fitness...
January 30, 2017: Nature Ecology & Evolution
F Javier Sangrós, Jesús Torrecilla, Carolina Giráldez-García, Lourdes Carrillo, José Mancera, Teresa Mur, Josep Franch, Javier Díez, Albert Goday, Rosario Serrano, F Javier García-Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Moreno, J Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, M Soledad Mayayo, Mercedes Del Castillo, Emma Navarro, Fernando Malo, Ainhoa Cambra, Riánsares López, M Ángel Gutiérrez, Luisa Gutiérrez, Carmen Boente, J Javier Mediavilla, Luis Prieto, Luis Mendo, M José Mansilla, Francisco Javier Ortega, Antonia Borras, L Gabriel Sánchez, J Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana M Hernández, Dulce Suárez, J Carlos Álvarez, Isabel Sáenz, F Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, M Teresa Marín, Félix Gutiérrez, Jaime Innerárity, M Del Mar Álvarez, Sara Artola, M Jesús Bedoya, Santiago Poveda, Fernando Álvarez, M Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, José Félix Rubio, M Carmen Durán, Julio Sagredo, M Teresa Gijón, M Ángeles Rollán, Pedro P Pérez, Javier Gamarra, Francisco Carbonell, Luis García-Giralda, J Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Antonio Ruiz, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, José Luis Torres, Concepción Blanco, Ángeles Jurado, José Luis Martín, Jorge Navarro, Gloria Sanz, Rafael Colas, Blanca Cordero, Cristina de Castro, Mercedes Ibáñez, Alicia Monzón, Nuria Porta, María Del Carmen Gómez, Rafael Llanes, J José Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J Carles González, M Isabel Bobé, Manel Mata, Irene Ruiz, Flora López, Marti Birules, Oriol Armengol, Rosa Mar de Miguel, Laura Romera, Belén Benito, Neus Piulats, Beatriz Bilbeny, J José Cabré, Xavier Cos, Ramón Pujol, Mateu Seguí, Carmen Losada, A María de Santiago, Pedro Muñoz, Enrique Regidor
INTRODUCTION AND OBJECTIVES: Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin). METHODS: Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase)...
August 5, 2017: Revista Española de Cardiología
Ester Borras, Kyle Chang, Mala Pande, Amanda Cuddy, Jennifer L Bosch, Sarah A Bannon, Maureen E Mork, Miguel A Rodriguez-Bigas, Melissa W Taggart, Patrick M Lynch, Y Nancy You, Eduardo Vilar
Lynch syndrome (LS) is a genetic condition secondary to germline alterations in the DNA mismatch repair (MMR) genes with 30% of changes being variants of uncertain significance (VUS). Our aim was to perform an in silico reclassification of VUS from a large single institutional cohort that will help prioritizing functional validation. A total of 54 VUS were detected with 33 (61%) novel variants. We integrated family history, pathology, and genetic information along with supporting evidence from eight different in silico tools at the RNA and protein level...
October 2017: Cancer Prevention Research
Rebeca Rivero, Fabrisio Alustiza, Virginia Capella, Cecilia Liaudat, Nancy Rodriguez, Pablo Bosch, Cesar Barbero, Claudia Rivarola
Cationic, anionic and non-ionic hydrogels having acrylamide polymer backbones were synthesized via free radical polymerization with N,N-methylenebisacrylamide (BIS) as crosslinker. The chemical structures of the hydrogels were characterized by Fourier Transform Infrared Spectroscopy (FTIR). Physicochemical properties such as swelling kinetic, maximum swelling capacity, volume phase transition temperature (VPTT) and wettability (static water contact angle) of hydrogels swollen in aqueous and cell culture medium, at room and cell culture temperatures were studied...
October 1, 2017: Colloids and Surfaces. B, Biointerfaces
Isabel González-Gascón Y Marín, María Hernández-Sanchez, Ana Eugenia Rodríguez-Vicente, Anna Puiggros, Rosa Collado, Elisa Luño, Teresa González, Neus Ruiz-Xivillé, Margarita Ortega, Eva Gimeno, Carolina Muñoz, Maria Stefania Infante, Julio Delgado, María Teresa Vargas, Marcos González, Francesc Bosch, Blanca Espinet, Jesús María Hernández-Rivas, José Ángel Hernández
We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q-), 17p13 (17p-) or trisomy 12 (+12)). The combination of 13q- with 11q- and 13q- with 17p-, accounted for 58.2% of the series, in contrast to 11q- with 17p- (3.7%). Patients carrying MA since diagnosis presented a short time to first therapy(TTFT) (27 months) and overall survival (OS) (76 months)...
July 21, 2017: Leukemia & Lymphoma
Ander Regueiro, Diego Fernández-Rodríguez, Xavier Freixa, Xavier Bosch, Victoria Martín-Yuste, Salvatore Brugaletta, Mercè Roqué, Manel Sabaté, Mónica Masotti
INTRODUCTION AND OBJECTIVES: ST-segment elevation myocardial infarction (STEMI) network activation by a noncardiologist reduces delay times but may increase the rate of false-positive STEMI diagnoses. We aimed to determine the prevalence, predictors, and clinical impact of false-positive activations within the Catalonian STEMI network (Codi Infart). METHODS: From January 2010 through December 2011, all consecutive patients treated within the Codi Infart network were included...
July 12, 2017: Revista Española de Cardiología
María Carmona-Iragui, Mircea Balasa, Bessy Benejam, Daniel Alcolea, Susana Fernández, Laura Videla, Isabel Sala, María Belén Sánchez-Saudinós, Estrella Morenas-Rodriguez, Roser Ribosa-Nogué, Ignacio Illán-Gala, Sofía Gonzalez-Ortiz, Jordi Clarimón, Frederick Schmitt, David K Powell, Beatriz Bosch, Albert Lladó, Michael S Rafii, Elizabeth Head, José Luis Molinuevo, Rafael Blesa, Sebastián Videla, Alberto Lleó, Raquel Sánchez-Valle, Juan Fortea
INTRODUCTION: We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than in sporadic early-onset forms of Alzheimer's disease (AD) (early-onset AD [EOAD]). METHODS: Neuroimaging features of CAA, apolipoprotein (APOE), and cerebrospinal fluid amyloid β (Aβ) 40 levels were studied in subjects with Down syndrome (DS, n = 117), autosomal-dominant AD (ADAD, n = 29), sporadic EOAD (n = 42), and healthy controls (n = 68)...
November 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Irene Consuegra, Clara Rodríguez-Aierbe, Inés Santiuste, Anna Bosch, Rosario Martínez-Marín, Ma Antonia Fortuto, Tatiana Díaz, Salvador Martí, Ma Ángeles Muñoz-Fernández
The Spanish Hematic Derivatives Group, consisting of 26 biobanks, was established in 2011. We describe here the viability results of our publically available standard operating procedure to freeze and thaw peripheral blood mononuclear cells (PBMCs). Our protocol maximizes PBMC viability while avoiding where possible interbiobank and intrabiobank assay variability.
August 2017: Biopreservation and Biobanking
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"