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rodriguez bosch

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https://www.readbyqxmd.com/read/28463681/cerebral-amyloid-angiopathy-in-down-syndrome-and-sporadic-and-autosomal-dominant-alzheimer-s-disease
#1
María Carmona-Iragui, Mircea Balasa, Bessy Benejam, Daniel Alcolea, Susana Fernández, Laura Videla, Isabel Sala, María Belén Sánchez-Saudinós, Estrella Morenas-Rodriguez, Roser Ribosa-Nogué, Ignacio Illán-Gala, Sofía Gonzalez-Ortiz, Jordi Clarimón, Frederick Schmitt, David K Powell, Beatriz Bosch, Albert Lladó, Michael S Rafii, Elizabeth Head, José Luis Molinuevo, Rafael Blesa, Sebastián Videla, Alberto Lleó, Raquel Sánchez-Valle, Juan Fortea
INTRODUCTION: We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than in sporadic early-onset forms of Alzheimer's disease (AD) (early-onset AD [EOAD]). METHODS: Neuroimaging features of CAA, apolipoprotein (APOE), and cerebrospinal fluid amyloid β (Aβ) 40 levels were studied in subjects with Down syndrome (DS, n = 117), autosomal-dominant AD (ADAD, n = 29), sporadic EOAD (n = 42), and healthy controls (n = 68)...
April 29, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28398808/isolation-methods-of-peripheral-blood-mononuclear-cells-in-spanish-biobanks-an-overview
#2
Irene Consuegra, Clara Rodríguez-Aierbe, Inés Santiuste, Anna Bosch, Rosario Martínez-Marín, Ma Antonia Fortuto, Tatiana Díaz, Salvador Martí, Ma Ángeles Muñoz-Fernández
The Spanish Hematic Derivatives Group, consisting of 26 biobanks, was established in 2011. We describe here the viability results of our publically available standard operating procedure to freeze and thaw peripheral blood mononuclear cells (PBMCs). Our protocol maximizes PBMC viability while avoiding where possible interbiobank and intrabiobank assay variability.
February 22, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28321779/transfection-of-bovine-fetal-fibroblast-with-polyethylenimine-pei-nanoparticles-effect-of-particle-size-and-presence-of-fetal-bovine-serum-on-transgene-delivery-and-cytotoxicity
#3
D O Forcato, A E Fili, F E Alustiza, J M Lázaro Martínez, S Bongiovanni Abel, M F Olmos Nicotra, A P Alessio, N Rodríguez, C Barbero, P Bosch
The development of efficient transfection protocols for livestock cells is crucial for implementation of cell-based transgenic methods to produce genetically modified animals. We synthetized fully deacylated linear 22, 87 and 217 kDa polyethylenimine (PEI) nanoparticles and compared their transfection efficiency and cytotoxicity to commercial branched 25 kDa PEI and linear 58 kDa poly(allylamine) hydrochloride. We studied the effect of PEI size and presence of serum on transfection efficiency on primary cultures of bovine fetal fibroblasts and established cells lines (HEK 293 and Hep G2)...
March 20, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28291123/medullary-carcinoma-of-the-penis-a-distinctive-hpv-related-neoplasm-a-report-of-12-cases
#4
Sofía Cañete-Portillo, Omar Clavero, Diego F Sanchez, Arturo Silvero, Francisco Abed, Ingrid M Rodriguez, Gustavo Ayala, Laia Alemany, Nubia Munoz, Silvia de Sanjose, Wim Quint, Francesc X Bosch, Antonio L Cubilla
A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Here we report a novel penile tumor associated with HPV. Twelve cases were selected from 1010 penile carcinomas, part of an international HPV detection study conducted at the Institut Català d'Oncologia, Barcelona, Spain. Immunostaining with p16 was performed on all cases, and HPV-mRNA detection was also performed...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28279691/-use-of-urine-drug-screening-in-the-emergency-department-of-a-paediatric-hospital
#5
Núria Ferrer Bosch, Lidia Martínez Sánchez, Victoria Trenchs Sainz de la Maza, Jesús Velasco Rodríguez, Elsa García González, Carles Luaces Cubells
OBJECTIVE: To describe the situations in which urine drug screening is used in a Paediatric Emergency Department (ED). An analysis is also made on its potential usefulness on whether it changes the patient management, and if the results are confirmed by using specific techniques. METHODOLOGY: A retrospective study was conducted on patients under the age of 18 attended in the ED during 2014 and in whom urine drug screening was requested. Depending on the potential capacity of the screening result to change patient management, two groups were defined (potentially useful and not potentially useful)...
March 6, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28225543/cuba-s-aging-and-alzheimer-longitudinal-study
#6
Juan de Jesús Llibre-Rodríguez, Adolfo Valhuerdi-Cepero, Ana M López-Medina, Lisseth Noriega-Fernández, Rutbeskia Porto-Álvarez, Milagros A Guerra-Hernández, Rodolfo I Bosch-Bayard, Tania Zayas-Llerena, Elaine Hernandez-Ulloa, Ana L Rodríguez-Blanco, Enrique Salazar-Pérez, Juan C Llibre-Guerra, Jorge J Llibre-Guerra, Beatriz Marcheco-Teruel
Aging and Alzheimer is a prospective, longitudinal cohort study involving 2944 adults aged ≥65 years from selected areas in Cuba's Havana and Matanzas Provinces. This door-to-door study, which began in 2003, includes periodic assessments of the cohort based on an interview; physical exam; anthropometric measurements; and diagnosis of dementia and its subtypes, other mental disorders, and other chronic non-communicable diseases and their risk factors. Information was gathered on sociodemographic characteristics; disability, dependency and frailty; use of health services; and characteristics of care and caregiver burden...
January 2017: MEDICC Review
https://www.readbyqxmd.com/read/28225490/clinical-characteristics-and-outcome-of-spanish-patients-with-anca-associated-vasculitides-impact-of-the-vasculitis-type-anca-specificity-and-treatment-on-mortality-and-morbidity
#7
MULTICENTER STUDY
Roser Solans-Laqué, Guadalupe Fraile, Monica Rodriguez-Carballeira, Luis Caminal, Maria J Castillo, Ferran Martínez-Valle, Luis Sáez, Juan J Rios, Xavier Solanich, Joaquim Oristrell, Francisco Pasquau, Eva Fonseca, Monica Zamora, Jose L Callejas, Begoña Frutos, Monica Abdilla, Patricia Fanlo, Isabel García-Sánchez, Miguel López-Dupla, Bernardo Sopeña, Almudena Pérez-Iglesias, Josep A Bosch
The aim of this study was to describe the clinical characteristics of ANCA-associated vasculitides (AAV) at presentation, in a wide cohort of Spanish patients, and to analyze the impact of the vasculitis type, ANCA specificity, prognostic factors, and treatments administered at diagnosis, in the outcome.A total of 450 patients diagnosed between January 1990 and January 2014 in 20 Hospitals from Spain were included. Altogether, 40.9% had granulomatosis with polyangiitis (GPA), 37.1% microscopic polyangiitis (MPA), and 22% eosinophilic granulomatosis with polyangiitis (EGPA)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28220453/epidemiology-of-sepsis-in-catalonia-analysis-of-incidence-and-outcomes-in-a-european-setting
#8
Juan Carlos Yébenes, Juan Carlos Ruiz-Rodriguez, Ricard Ferrer, Montserrat Clèries, Anna Bosch, Carol Lorencio, Alejandro Rodriguez, Xavier Nuvials, Ignacio Martin-Loeches, Antoni Artigas
BACKGROUND: Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding selection bias in relation to different complexity hospitals. METHODS: A large retrospective analysis of a 5-year period (2008-2012) was conducted of hospital discharge records obtained from the Catalan Health System (CatSalut) Minimum Basic Data Set for Acute-Care Hospitals (a mandatory population-based register of admissions to all public and private acute-care hospitals in Catalonia)...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28201713/escherichia-coli-an-old-friend-with-new-tidings
#9
J Vila, E Sáez-López, J R Johnson, U Römling, U Dobrindt, R Cantón, C G Giske, T Naas, A Carattoli, M Martínez-Medina, J Bosch, P Retamar, J Rodríguez-Baño, F Baquero, S M Soto
No abstract text is available yet for this article.
July 1, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28198025/haemoglobin-responses-to-transfusion-in-severe-iron-deficiency-anaemia-potential-impact-of-gastrointestinal-disorders
#10
X Bosch, E Montori, M Guerra-García, J Costa-Rodríguez, M H Quintanilla, P E Tolosa-Chapasian, P Moreno, N Guasch, A López-Soto
BACKGROUND AND OBJECTIVES: Red blood cell (RBC) transfusion may be justified in iron deficiency anaemia (IDA) when an increase in oxygen delivery is needed, as sometimes occurs in subjects with haemoglobin <8·0 mg/dL, serious comorbidities or at risk of cardiovascular instability. Earlier investigations showed that some patients with severe IDA requiring transfusion had lower than expected post-transfusion haemoglobin levels with poorer clinical outcomes than other patients. After hypothesizing that haemoglobin responses to transfusion were different and that the underlying gastrointestinal (GI) disorders causing IDA could be a confounder explaining this association, these responses were analysed in a prospective cohort of IDA adults referred for outpatient GI investigation...
April 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28187641/cryptic-within-cryptic-genetics-morphometrics-and-bioacoustics-delimitate%C3%A2-a-new-species-of-i-eleutherodactylus-i-anura-eleutherodactylidae-from-eastern-cuba
#11
Ariel Rodríguez, Álvaro Dugo-Cota, Santiago Montero-Mendieta, Alejandro Gonzalez-Voyer, Roberto Alonso Bosch, Miguel Vences, Carles Vilà
We studied the variation in genetics, bioacustics, and morphology in Eleutherodactylus glamyrus, a regionally endemic frog species restricted to high elevations in the Sierra Maestra Massif, Western Cuba that was originally described as a cryptic species hidden under the name E. auriculatus. Genetic analysis of mtDNA sequences of the 16S and cob genes identify two allopatric and strongly supported mitochondrial clades (phylogroups) which also showed no haplotype sharing in the nuclear Rag-1 gene. Bioacustic, and morphological comparisons concordantly identify these two phylogroups as independent evolutionary lineages...
January 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/28094842/impact-of-microbial-invasion-of-amniotic-cavity-and-the-type-of-microorganisms-on-short-term-neonatal-outcome-in-women-with-preterm-labor-and-intact-membranes
#12
Teresa Cobo, Irene Vives, Adriano Rodríguez-Trujillo, Clara Murillo, Martina A Ángeles, Jordi Bosch, Andrea Vergara, Eduard Gratacós, Montse Palacio
INTRODUCTION: The objective was to evaluate the impact of microbial invasion of the amniotic cavity and the type of microorganisms on pregnancy and short-term neonatal outcomes in women with preterm labor. MATERIAL AND METHODS: Prospective observational cohort study including women with preterm labor from 22.0 to 36.0 weeks. Microbial invasion of the amniotic cavity was defined based on amniotic fluid aerobic/anaerobic/mycoplasma cultures, and intra-amniotic inflammation on amniotic fluid interleukin-6 levels...
January 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28088073/strategies-to-design-clinical-studies-to-identify-predictive-biomarkers-in-cancer-research
#13
REVIEW
Jose Luis Perez-Gracia, Miguel F Sanmamed, Ana Bosch, Ana Patiño-Garcia, Kurt A Schalper, Victor Segura, Joaquim Bellmunt, Josep Tabernero, Christopher J Sweeney, Toni K Choueiri, Miguel Martín, Juan Pablo Fusco, Maria Esperanza Rodriguez-Ruiz, Alfonso Calvo, Celia Prior, Luis Paz-Ares, Ruben Pio, Enrique Gonzalez-Billalabeitia, Alvaro Gonzalez Hernandez, David Páez, Jose María Piulats, Alfonso Gurpide, Mapi Andueza, Guillermo de Velasco, Roberto Pazo, Enrique Grande, Pilar Nicolas, Francisco Abad-Santos, Jesus Garcia-Donas, Daniel Castellano, María J Pajares, Cristina Suarez, Ramon Colomer, Luis M Montuenga, Ignacio Melero
The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promising targets and are seldom validated. The lack of a proper methodology also determines that many anti-cancer drugs are developed below their potential, due to failure to identify predictive biomarkers...
February 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28065528/a-comprehensive-evaluation-of-the-gastrointestinal-tract-in-iron-deficiency-anemia-with-predefined-hemoglobin-below-9mg-dl-a-prospective-cohort-study
#14
Xavier Bosch, Elisabet Montori, Mar Guerra-García, Jaime Costa-Rodríguez, Mariano H Quintanilla, Paula E Tolosa-Chapasian, Pedro Moreno, Neus Guasch, Alfons López-Soto
BACKGROUND: Anemia is defined as hemoglobin below the cutoff of normal in studies examining the gastrointestinal (GI) tract in iron-deficiency anemia (IDA). Although the risk of GI cancer (GIC) increases as hemoglobin decreases, guidelines do not usually recommend hemoglobin thresholds for IDA investigation. METHODS: To elucidate whether underlying GI disorders explain the different hemoglobin values and clinical outcomes observed initially in IDA patients referred for GI workup, we prospectively investigated the diagnostic yield of a thorough GI examination in consecutive IDA adults with predefined hemoglobin <9g/dL and no extraintestinal bleeding...
April 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28053046/properties-of-human-disease-genes-and-the-role-of-genes-linked-to-mendelian-disorders-in-complex-disease-aetiology
#15
Nino Spataro, Juan Antonio Rodríguez, Arcadi Navarro, Elena Bosch
Do genes presenting variation that has been linked to human disease have different biological properties than genes that have never been related to disease? What is the relationship between disease and fitness? Are the evolutionary pressures that affect genes linked to Mendelian diseases the same to those acting on genes whose variation contributes to complex disorders? The answers to these questions could shed light on the architecture of human genetic disorders and may have relevant implications when designing mapping strategies in future genetic studies...
February 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28040474/deep-sequencing-in-the-management-of-hepatitis-virus-infections
#16
REVIEW
Josep Quer, Francisco Rodríguez-Frias, Josep Gregori, David Tabernero, Maria Eugenia Soria, Damir García-Cehic, Maria Homs, Albert Bosch, Rosa María Pintó, Juan Ignacio Esteban, Esteban Domingo, Celia Perales
The hepatitis viruses represent a major public health problem worldwide. Procedures for characterization of the genomic composition of their populations, accurate diagnosis, identification of multiple infections, and information on inhibitor-escape mutants for treatment decisions are needed. Deep sequencing methodologies are extremely useful for these viruses since they replicate as complex and dynamic quasispecies swarms whose complexity and mutant composition are biologically relevant traits. Population complexity is a major challenge for disease prevention and control, but also an opportunity to distinguish among related but phenotypically distinct variants that might anticipate disease progression and treatment outcome...
December 28, 2016: Virus Research
https://www.readbyqxmd.com/read/27935108/abscisic-acid-and-transpiration-rate-are-involved-in-the-response-to-boron-toxicity-in-arabidopsis-plants
#17
Miguel Ángel Macho-Rivero, Juan José Camacho-Cristóbal, María Begoña Herrera-Rodríguez, Maren Müller, Sergi Munné-Bosch, Agustín González-Fontes
Boron (B) is an essential microelement for vascular plant development, but its toxicity is a major problem affecting crop yields in arid and semi-arid areas of the world. In the literature, several genes involved in abscisic acid (ABA) signalling and responses are upregulated in Arabidopsis roots after treatment with excess B. It is known that the AtNCED3 gene, which encodes a crucial enzyme for ABA biosynthesis, plays a key role in the plant response to drought stress. In this study, root AtNCED3 expression and shoot ABA content were rapidly increased in wild-type plants upon B-toxicity treatment...
December 9, 2016: Physiologia Plantarum
https://www.readbyqxmd.com/read/27829648/cuba-s-strategy-for-alzheimer-disease-and-dementia-syndromes
#18
Rodolfo I Bosch-Bayard, Juan J Llibre-Rodríguez, Alberto Fernández-Seco, Carmen Borrego-Calzadilla, Mayra R Carrasco-García, Tania Zayas-Llerena, Carmen R Moreno-Carbonell, Ana G Reymond-Vasconcelos
Dementia is a great challenge to public health in Cuba due to its impact on society and families. Cuba's National Intervention Strategy for Alzheimer Disease and Dementia Syndromes is designed to address this challenge. The Strategy includes working guidelines for primary and secondary care, education about rights of people with cognitive impairment, professional development, research, and health promotion and dementia prevention. An associated action plan, focused on primary care, includes proposals for creation of memory clinics, day centers and comprehensive rehabilitation services for cognitive stimulation...
October 2016: MEDICC Review
https://www.readbyqxmd.com/read/27821812/karyotypic-complexity-rather-than-chromosome-8-abnormalities-aggravates-the-outcome-of-chronic-lymphocytic-leukemia-patients-with-tp53-aberrations
#19
Gonzalo Blanco, Anna Puiggros, Panagiotis Baliakas, Anastasia Athanasiadou, MªDolores García-Malo, Rosa Collado, Aliki Xochelli, María Rodríguez-Rivera, Margarita Ortega, Mª José Calasanz, Elisa Luño, MªTeresa Vargas, Javier Grau, Carolina Martínez-Laperche, Alberto Valiente, José Cervera, Achilles Anagnostopoulos, Eva Gimeno, Eugènia Abella, Evangelia Stalika, Jesús Mª Hernández-Rivas, Francisco José Ortuño, Diego Robles, Ana Ferrer, David Ivars, Marcos González, Francesc Bosch, Pau Abrisqueta, Kostas Stamatopoulos, Blanca Espinet
Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14...
December 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27808108/improving-virus-production-through-quasispecies-genomic-selection-and-molecular-breeding
#20
Francisco J Pérez-Rodríguez, Lucía D'Andrea, Montserrat de Castellarnau, Maria Isabel Costafreda, Susana Guix, Enric Ribes, Josep Quer, Josep Gregori, Albert Bosch, Rosa M Pintó
Virus production still is a challenging issue in antigen manufacture, particularly with slow-growing viruses. Deep-sequencing of genomic regions indicative of efficient replication may be used to identify high-fitness minority individuals suppressed by the ensemble of mutants in a virus quasispecies. Molecular breeding of quasispecies containing colonizer individuals, under regimes allowing more than one replicative cycle, is a strategy to select the fittest competitors among the colonizers. A slow-growing cell culture-adapted hepatitis A virus strain was employed as a model for this strategy...
November 3, 2016: Scientific Reports
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