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Intracranial AVM

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https://www.readbyqxmd.com/read/27911248/international-multicenter-cohort-study-of-pediatric-brain-arteriovenous-malformations-part-1-predictors-of-hemorrhagic-presentation
#1
Dale Ding, Robert M Starke, Hideyuki Kano, David Mathieu, Paul P Huang, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Symeon Missios, Douglas Kondziolka, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Brain arteriovenous malformations (AVMs) are the most common cause of spontaneous intracranial hemorrhage in pediatric patients (age < 18 years). Since the cumulative lifetime risk of AVM hemorrhage is considerable in children, an improved understanding of the risk factors influencing hemorrhagic presentation may aid in the management of pediatric AVMs. The aims of this first of a 2-part multicenter, retrospective cohort study are to evaluate the incidence and determine the predictors of hemorrhagic presentation in pediatric AVM patients...
December 2, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27903193/three-dimensional-assessment-of-the-effects-of-high-density-embolization-material-on-the-absorbed-dose-in-the-target-for-gamma-knife-radiosurgery-of-arteriovenous-malformations
#2
Yoichi Watanabe, Divyajot Sandhu, Leighton Warmington, Sean Moen, Ramachandra Tummala
OBJECTIVE Arteriovenous malformation (AVM) is an intracranial vascular disorder. Gamma Knife radiosurgery (GKRS) is used in conjunction with intraarterial embolization to eradicate the nidus of AVMs. Clinical results indicate that patients with prior embolization tend to gain less benefit from GKRS. The authors hypothesized that this was partly caused by dosimetric deficiency. The actual dose delivered to the target may be smaller than the intended dose because of increased photon attenuation by high-density embolic materials...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27869147/interplay-between-vegf-and-nrf2-regulates-angiogenesis-due-to-intracranial-venous-hypertension
#3
Liwen Li, Hao Pan, Handong Wang, Xiang Li, Xiaomin Bu, Qiang Wang, Yongyue Gao, Guodao Wen, Yali Zhou, Zixiang Cong, Youqing Yang, Chao Tang, Zhengwei Liu
Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with the HIF-1α/VEGF signaling pathway. Nuclear factor erythroid 2-related factor 2(Nrf2) significantly influences angiogenesis; however, the interplay between Nrf2 and VEGF under VH in brain AVMs remains unclear. Therefore, our study aimed to investigate the interplay between Nrf2 and VEGF due to VH in brain AVMs. Immunohistochemistry indicated that Nrf2 and VEGF were highly expressed in human brain AVM tissues...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27815963/the-management-of-symptomatic-cerebral-developmental-venous-anomalies-a-clinical-experience-of-43-cases
#4
Xin-Guang Yu, Chen Wu, Hui Zhang, Zheng-Hui Sun, Zhi-Qiang Cui
BACKGROUND Developmental venous anomalies (DVAs) are rare vascular diseases becoming more frequently diagnosed. Most patients with DVAs have no clinical symptoms with the exception of a few patients with epilepsy, intracranial hemorrhage, or neuro-function deficit. There is still controversy with respect to treatment strategies for symptomatic DVAs. MATERIAL AND METHODS Forty-three cases of symptomatic DVAs from January 2006 to October 2015 were retrospectively reviewed and the imaging characteristics of DVAs by CT, MRI, and DSA and the treatment modalities for DVAs were studied...
November 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27760058/time-of-arrival-parametric-maps-and-virtual-bolus-images-derived-from-contrast-enhanced-time-resolved-radial-magnetic-resonance-angiography-improve-the-display-of-brain-arteriovenous-malformation-vascular-anatomy
#5
Tilman Schubert, Yijing Wu, Kevin M Johnson, Oliver Wieben, Jane Maksimovic, Charles Mistretta, Patrick Turski
OBJECTIVES: Time-of-arrival (TOA) maps can be derived from high-resolution 4-dimensional (4D) contrast-enhanced magnetic resonance angiography (MRA) data sets to provide a quantitative description of contrast material arrival time in each voxel. This information can further be processed to create a compressed time evolution curve that virtually shortens the contrast bolus (virtual bolus [VB]). The purpose of this project was to determine whether TOA-enhanced 4D MRA and/or VB imaging improve the display of contrast kinetics in patients with vascular disease...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27757503/predictors-for-occlusion-of-cerebral-avms-following-radiation-therapy-radiation-dose-and-prior-embolization-but-not-spetzler-martin-grade
#6
Stefan Knippen, Florian Putz, Sabine Semrau, Ulrike Lambrecht, Arzu Knippen, Michael Buchfelder, Sven Schlaffer, Tobias Struffert, Rainer Fietkau
BACKGROUND: Intracranial arteriovenous malformations (AVMs) may show a harmful development. AVMs are treated by surgery, embolization, or radiation therapy. OBJECTIVE: This study investigated obliteration rates and side effects in patients with AVMs treated by radiation therapy. METHODS: A total of 40 cases treated between 2005 and 2013 were analyzed. Single-dose stereotactic radiosurgery (SRS) was received by 13 patients and 27 received hypofractionated stereotactic radiation therapy (HSRT)...
October 18, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27637643/multimodality-management-of-cerebral-arteriovenous-malformations-with-special-reference-to-avm-related-hemorrhages-during-ongoing-staged-treatment
#7
Andreas Gruber, Gerhard Bavinzski, Klaus Kitz, Stephan Barthelmes, Magdalena Mayr, Engelbert Knosp
In this study we report and analyze the results of a multimodality management concept for intracranial arteriovenous malformations (AVMs), including microsurgery, embolization, and gamma knife radiosurgery. The study population consists of a consecutive series of 294 patients treated for 304 intracranial AVMs over a 10-year period.
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27601322/endovascular-treatment-of-pediatric-intracranial-arteriovenous-shunting
#8
Yasunari Niimi
Intracranial arteriovenous shunts (ICAVSs) in young children are characterized with frequent high flow fistulas. In association of high flow fistulas and physiological condition of the developing brain and heart, each disease tends to present at a certain age with unique symptoms. Vein of Galen aneurysmal malformation (VGAM) and dural sinus malformation (DSM) with arteriovenous (AV) shunts tend to present in neonate with high output cardiac failure. In infancy, VGAM, pial AVF and infantile dural AVF tend to present with hydrodynamic disorder such as macrocephaly, ventriculomegaly, prominent facial veins, and developmental delay...
September 7, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27588055/treatment-of-a-giant-arteriovenous-malformation-associated-with-intracranial-aneurysm-rupture-during-pregnancy-a-case-report
#9
Junhui Chen, Yuhai Wang, Peipei Li, Weiliang Chen, Jingxu Zhou, Xu Hu, Jie Zhu, Bingjie Jiang
Arteriovenous malformations (AVMs) associated with aneurysm have rarely been reported in the literature. The present study reports the case of a 21-year-old pregnant female patient who presented with a subarachnoid hemorrhage and an intracranial hematoma located in the anterior end of the corpus callosum. Furthermore, an anterior cerebral aneurysm and an AVM were identified by digital subtraction angiography and magnetic resonance angiography. The aneurysm was clipped and the AVM was successfully removed by microsurgery...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27550214/post-procedure-headache-in-patients-treated-for-neurovascular-arteriovenous-malformations-and-aneurysms-using-endovascular-therapy
#10
Sabrina Khan, Faisal Mohammad Amin, John Hauerberg, Markus Holtmannspötter, Julie Falkenberg Petersen, Zainab Fakhril-Din, David Gaist, Messoud Ashina
BACKGROUND: Though endovascular therapy (EVT) is increasingly applied in the treatment of intracranial vascular lesions, little is known about the effect of EVT on post-procedure headache. We aimed to investigate the prevalence of headache in patients who have undergone EVT for cerebral arteriovenous malformations (AVMs) and aneurysms. METHODS: A total of 324 patients underwent EVT treatment for aneurysms and AVMs at the Danish National Hospital from January 2012 to December 2014...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27544231/risk-of-hemorrhage-in-patients-over-age-60-with-arteriovenous-malformations-avms
#11
Wuyang Yang, Jose L Porras, Alice L Hung, Syed Khalid, Tomas Garzon-Muvdi, Justin M Caplan, Maria Braileanu, Joanna Y Wang, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Judy Huang
Treatment selection for patients 60years of age and older with intracranial arteriovenous malformations (AVMs), requires careful consideration of the natural history and post-treatment hemorrhagic risk. We aimed to directly compare the natural history of AVMs with post-treatment hemorrhagic risk in this population. We retrospectively reviewed our AVM database of 683 patients. Patients ⩾60years at diagnosis were included. Treatment modality was divided into four groups: surgery±embolization (SE), radiosurgery±embolization (RE), embolization only (Emb), and observation (Obs)...
August 17, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27533644/retinal-arteriovenous-malformation
#12
Kevin H Patel, Ananda Kalevar, H Richard McDonald, Robert N Johnson
PURPOSE: To describe a case of an isolated Group 3 retinal arteriovenous malformation (AVM). METHODS: Observational case report. RESULTS: A 15-year-old girl with no significant medical history presented with no light perception vision in her right eye and gradually decreasing vision in her left eye over several years. She was found to have a large AVM in the posterior pole of the right eye with associated perivascular sheathing in the periphery...
August 16, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27509452/gamma-knife-radiosurgery-for-arteriovenous-malformations-clinical-series-of-199-patients
#13
Ipek Arslan, Evrim Tezcanli, Meltem Yilmaz, Olcay Cizmeli, Meric Sengoz, Selcuk Peker
AIM: Cerebral arteriovenous malformations (AVM) are pathological connections between arteries and veins without capillaries. Stereotactic radiosurgery (RS) is a proven and accepted treatment method for cerebral AVMs. Our objective was to analyze the factors influencing the clinical outcome in patients suffering from AVMs. MATERIAL AND METHODS: We retrospectively reviewed 199 patients who were treated with Gamma-Knife RS for intracranial AVMs between 13 October 2005 and 31 October 2010...
September 21, 2015: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27492375/time-resolved-3d-rotational-angiography-display-of-detailed-neurovascular-anatomy-in-patients-with-intracranial-vascular-malformations
#14
Stephanie Lescher, Sonja Gehrisch, Sigrun Klein, Joachim Berkefeld
PURPOSE: The purpose of this pilot study was to demonstrate the applicability of time-resolved three-dimensional (3D) reconstructions from 3D digital subtraction angiography (DSA) rotational angiography (RA) datasets (four-dimensional (4D) DSA) to provide a more detailed display of the architecture of intracranial vascular malformations. METHODS: The experimental reconstruction software was applied to the existing 3D DSA datasets obtained with Siemens Artis zee biplane neuroangiography equipment...
August 4, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27473023/rapid-spontaneous-obliteration-of-intracranial-arteriovenous-malformation
#15
William R Stetler, Adam J Polikfa, W Christopher Fox, Brian Hoh
A 35-year-old male presented with headaches and was found to have a Spetzler-Martin grade 2 right occipital arteriovenous malformation (AVM) with single, superficial draining vein. The patient opted to undergo embolization for possible cure with resection scheduled in the event complete obliteration was not achieved. Three weeks later, angiography during his embolization procedure revealed that the AVM had spontaneously obliterated; no treatment was required. In conjunction with prior case reports/series, this patient highlights the need for current imaging prior to proceeding with intervention to confirm that spontaneous obliteration has not occurred between diagnosis and treatment...
July 26, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27399504/306%C3%A2-worse-stereotactic-radiosurgery-outcomes-for-intracranial-arteriovenous-malformations-after-repeat-vs-initial-treatment-a-matched-cohort-study
#16
Dale Ding, Zhiyuan Xu, Han-Hsun Shih, Robert M Starke, Chun-Po Yen, Or Cohen-Inbar, Jason P Sheehan
INTRODUCTION: Incompletely obliterated intracranial arteriovenous malformations (AVMs) after initial treatment with stereotactic radiosurgery (SRS) can be treated with a repeat session of SRS. However, the relative efficacy of repeat vs initial SRS is not well defined. The goal of this retrospective case-control study is to compare the outcomes of repeat vs initial SRS for the treatment of matched cohorts comprising angioarchitecturally similar AVMs. METHODS: We evaluated a prospective database of AVM patients treated with SRS from 1989 to 2013...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27399483/204%C3%A2-pediatrics-arteriovenous-malformations-treatment-with-stereotactic-radiosurgery-gamma-knife-our-institutional-experience
#17
Jody Filippo Capitanio, Alberto Luigi Gallotti, Pietro Panni, Silvia Snider, Francesco Scomazzoni, Pietro Mortini
INTRODUCTION: Arteriovenous malformations (AVMs) are the most common cause of intracranial hemorrhages in children. It is estimated that 12.18% will be symptomatic during the childhood. AVM obliteration depends on several factors, among the most important is a proper stereotactic nidus definition followed by delivery of an adequate dose. METHODS: We retrospectively reviewed 24 children (13 girls and 11 boys) treated with stereotactic radiosurgery Gamma knife (SRS GK) between 2001 and 2014...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27399435/156%C3%A2-effect-of-associated-arterial-aneurysms-on-outcomes-after-stereotactic-radiosurgery-for-intracranial-arteriovenous-malformations-a-matched-cohort-study
#18
Dale Ding, Zhiyuan Xu, Robert M Starke, Chun-Po Yen, Han-Hsun Shih, Thomas Buell, Jason P Sheehan
INTRODUCTION: Approximately 10% to 30% of intracranial arteriovenous malformations (AVMs) harbor AVM-associated arterial aneurysms (AAAs). The presence of an AAA has been found to significantly increase an untreated AVM's hemorrhage risk. Previous studies have also shown AVMs with patent AAAs to have higher hemorrhage rates after treatment with stereotactic radiosurgery (SRS). However, the effect of AAAs on AVM SRS outcomes remains incompletely understood. Therefore, the aim of this retrospective, matched cohort study is to determine the effect of AAAs on outcomes after SRS for AVMs...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27399392/112%C3%A2-stereotactic-radiosurgery-for-intracranial-arteriovenous-malformations-with-intranidal-and-prenidal-arterial-aneurysms
#19
Dale Ding, Zhiyuan Xu, Robert M Starke, Chun-Po Yen, Han-Hsun Shih, Thomas Buell, Jason P Sheehan
INTRODUCTION: The outcomes of stereotactic radiosurgery (SRS) for intracranial arteriovenous malformations (AVMs) with patent intranidal and prenidal AVM-associated arterial aneurysms (AAA) are poorly understood, because many AAAs are embolized before nidal intervention. The aim of this retrospective cohort study is to analyze the SRS outcomes for AVMs with AAAs. METHODS: We evaluated an institutional database of AVMs treated with Gamma Knife SRS from 1989 to 2013...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27366251/the-focus-on-aneurysm-principle-classification-and-surgical-principles-of-management-of-concurrent-arterial-aneurysm-with-arteriovenous-malformation-causing-intracranial-hemorrhage
#20
Vikas Jha, Sanjay Behari, Awadhesh K Jaiswal, Kamlesh Singh Bhaisora, Yogesh P Shende, Rajendra V Phadke
CONTEXT: Concurrent arterial aneurysms (AAs) occurring in 2.7-16.7% patients harboring an arteriovenous malformation (AVM) aggravate the risk of intracranial hemorrhage. AIM: We evaluate the variations of aneurysms simultaneously coexisting with AVMs. A classification-based management strategy and an abbreviated nomenclature that describes their radiological features is also proposed. SETTING: Tertiary care academic institute. STATISTICS: Test of significance applied to determine the factors causing rebleeding in the groups of patients with concurrent AVM and aneurysm and those with only AVMs...
July 2016: Asian Journal of Neurosurgery
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