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current controversies management of colorectal carcinoma

Aaron J Franke, Hiral Parekh, Jason S Starr, Sanda A Tan, Atif Iqbal, Thomas J George
Colorectal carcinoma is the second leading cause of cancer-related deaths in the United States, with rectal cancer accounting for approximately one-third of newly diagnosed cases, thus representing a major socioeconomic health burden. Although minimally invasive procedures (ie, transanal excision) may be appropriate for a subset of patients with small, superficially invasive tumors, a more comprehensive trimodality approach with neoadjuvant chemoradiotherapy, total mesorectal excision, and systemic chemotherapy is recommended for medically operable patients with nonmetastatic, locally advanced rectal cancer (LARC)...
March 2018: Clinical Colorectal Cancer
Isidoro Di Carlo, Adriana Toro
The annual World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO) was held in Bangkok, Thailand, from 5-9 December 2012, hosted under the auspices of the President of the Association, Masatoshi Makuuchi and the General Secretary Nicolas Lygidakis. The President of the Congress and of the local committee was Nopadol Wora-Urai from Bangkok University (Bangkok, Thailand). The organization of the congress was excellent, and both the location and the kindness of the local people were marvellous...
April 2013: Future Oncology
James Clark, Paul Ziprin
Transanal endoscopic microsurgery (TEMS) will play an even greater role in the treatment of rectal cancer as the UK national colorectal cancer screening program becomes national. With more rectal tumors being uncovered at earlier stages, a greater emphasis will be placed on treatment options that do not involve radical surgery and the possibility of a stoma. This article reviews the data surrounding TEMS, focusing on its current role in the treatment of early rectal cancer but with a view on how this option may develop in the future, particularly with regards to the more advanced rectal cancers and in view of the improved chemoradiotherapy regimens available...
February 2008: Future Oncology
Tsung-Jen Huang, Jaw-Yuan Wang, Li-Wei Lee, Fang-Ming Chen, Chieh-Han Chuan, Hon-Man Chan, Ming-Feng Hou, Che-Jen Huang, Yu-Sheng Huang, Jan-Sing Hsieh
A one-stage operation for obstructing left-sided colorectal carcinoma remains controversial. This study was performed to compare our surgical management of patients with left-sided colorectal cancer (at or distal to splenic flexure) obstruction presenting to the Kaohsiung Medical University Hospital from January 1995 to December 2000. Ninety-six patients underwent immediate operation within 24 hours of admission. Of these, 73 patients (76%) who underwent immediate tumor resection and anastomosis in one stage after appropriate resuscitation were enrolled into our study...
July 2002: Kaohsiung Journal of Medical Sciences
M J Eskelinen, U H Haglund
Cancer of the exocrine pancreas is a disease of considerable importance in gastroenterology. In Western countries it is the fourth commonest cause of death from cancer after those of lung, colorectal, and breast. The incidence of pancreatic carcinoma has increased in Northern Europe and North America during recent decades and contrary to for example, lung, gastric and oesophageal carcinoma, its incidence is still increasing the annual incidence is about 8-10/100,000 population. The causes of its increased incidence are unknown, as is the aetiology of the disease itself...
April 1999: European Journal of Surgery, Acta Chirurgica
L Stocchi, H Nelson
PURPOSE: The study contained herein was undertaken to review and summarize the current literature on diagnostic and therapeutic applications of monoclonal antibodies in colorectal cancer. RESULTS: Limitations of traditional imaging techniques have encouraged development of targeted imaging strategies using radiolabeled monoclonal antibodies. Diagnostic immunoscintigraphy can detect lesions not identified by conventional imaging modalities, although it has not proven useful in the management of primary colorectal cancers and in hepatic metastases...
February 1998: Diseases of the Colon and Rectum
M P Boente, K Yeh, W M Hogan, R F Ozols
Colon and rectal carcinomas. Accurate staging of colon and rectal carcinomas (CRCs) is vital to insure appropriate surgical and adjuvant therapy, and appropriate enrollment in and interpretation of adjuvant or neoadjuvant trials. Historically, CRC staging has relied on pathologic examination of surgical speciments. These newer techniques of endoscopic and intraoperative ultrasound, laparoscopy, and radioimmunoguided surgery may permit increased accuracy of staging by the surgeon. Cautious interpretation of investigations of these modalities is warranted, as studies include small numbers of patients and some of the work is preliminary...
1996: Cancer Treatment and Research
M Lise, P P Da Pian, D Nitti, P L Pilati, C Prevaldi
The management of patients with hepatic metastases from colorectal carcinoma is controversial. While a "no treatment" attitude still persists, other patients undergo systemic chemotherapy with very limited results. Other possible options are hepatic resection and locoregional treatments. One hundred twenty-three patients with hepatic metastases from colorectal cancer were treated at the authors' institution over a period of 15 years. Thirty-nine patients underwent hepatic resection while 84 underwent various forms of locoregional treatment...
August 1990: Diseases of the Colon and Rectum
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