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https://www.readbyqxmd.com/read/28916723/fibroblast-growth-factor-2-fgf2-regulates-cytoglobin-expression-and-activation-of-human-hepatic-stellate-cells-via-jnk-signaling
#1
Misako Sato-Matsubara, Tsutomu Matsubara, Atsuko Daikoku, Yoshinori Okina, Lisa Longato, Krista Rombouts, Le Thi Thanh Thuy, Jun Adachi, Takeshi Tomonaga, Kazuo Ikeda, Katsutoshi Yoshizato, Massimo Pinzani, Norifumi Kawada
Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in hepatic stellate cells (HSCs) in the liver. In addition to its gas-binding ability, CYGB is relevant to hepatic inflammation, fibrosis, and cancer because of its antioxidative properties; however, the regulation of CYGB gene expression remains unknown. Here, we sought to identify factors that induce CYGB expression in HSCs and to clarify the molecular mechanism involved. We used the human HSC cell line HHSteC and primary human HSCs isolated from intact human liver tissues...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28899582/fgf2-mediated-attenuation-of-myofibroblast-activation-is-modulated-by-distinct-mapk-signaling-pathways-in-human-dermal-fibroblasts
#2
David M Dolivo, Sara A Larson, Tanja Dominko
BACKGROUND: Previous human and animal studies have demonstrated the ability of exogenously administered basic fibroblast growth factor (FGF2) to act as an antifibrotic agent in the skin. Though the activity of FGF2 as an anti-scarring agent is well-established for fibrotic skin wounds, the mechanisms by which FGF2 exerts these actions are not entirely understood. Canonical FGF2 signaling proceeds in part via FGFR/MAPK pathways in human dermal fibroblasts, and FGF2 has been described to prevent or reverse the fibroblast-to-myofibroblast transition, which is driven by TGFβ signaling and understood to be an important step in the formation of a fibrotic scar in vivo...
September 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28799756/caffeic-acid-phenethyl-ester-propolis-extract-ameliorates-insulin-resistance-by-inhibiting-jnk-and-nf-%C3%AE%C2%BAb-inflammatory-pathways-in-diabetic-mice-and-hepg2-cells-models
#3
Jia-Rui Nie, Ya-Ning Chang, Yujia Li, Yingjun Zhou, Jiawen Qin, Zhen Sun, Haibin Li
Caffeic acid phenethyl ester (CAPE), extracted from propolis, was evaluated the ameliorative effects on insulin resistance and identified the mechanisms, using noninsulin-dependent diabetes mellitus (NIDDM) model mice and insulin resistance (IR) model cells. After 5-week of CAPE supplementation, insulin sensitivity, hyperlipidemia, and peroxisome proliferator-activated receptor-α (PPAR-α) levels were improved in mice. Pro-inflammatory cytokines in serum and the expressions of tumour necrosis factor- alpha (TNF-α) mRNA in tissues were markedly down-regulated from CAPE-treated mice...
August 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28769771/upregulation-of-matrix-metalloproteinase-9-in-primary-cultured-rat-astrocytes-induced-by-2-chloroethanol-via-mapk-signal-pathways
#4
Tong Wang, Yingjun Liao, Qi Sun, Hongge Tang, Gaoyang Wang, Fenghong Zhao, Yaping Jin
2-Chloroethanol (2-CE) is one of the reactive metabolites of 1,2-DCE in vivo, which might contribute to brain edema formation induced by 1,2-dichloroethane (1,2-DCE) poisoning. Thus, the purpose of this study was to explore the roles of mitogen-activated protein kinase (MAPK) signal pathways in upregulation of matrix metalloproteinase-9 (MMP-9) in 2-CE exposed rat astrocytes. Expression of p38 MAPK (p38), extracellular signal regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK) and MMP-9 at both protein and gene levels in rat astrocytes were determined using western blot and real-time RT-PCR methods...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28689355/vitamin-d3-reverses-the-hippocampal-cytoskeleton-imbalance-but-not-memory-deficits-caused-by-ovariectomy-in-adult-wistar-rats
#5
Cassiana Siebert, Paula Pierozan, Janaina Kolling, Tiago Marcon Dos Santos, Matheus Coimbra Sebotaio, Eduardo Peil Marques, Helena Biasibetti, Aline Longoni, Fernanda Ferreira, Regina Pessoa-Pureur, Carlos Alexandre Netto, Angela T S Wyse
The objective of study was to investigate changes caused by ovariectomy (OVX) on aversive and non-aversive memories, as well as on cytoskeleton phosphorylating system and on vitamin D receptor (VDR) immunocontent in hippocampus. The neuroprotective role of vitamin D was also investigated. Ninety-day-old female Wistar rats were divided into four groups: SHAM, OVX, VITAMIN D and OVX + VITAMIN D; 30 days after the OVX, vitamin D supplementation (500 IU/kg), by gavage, for 30 days was started. Results showed that OVX impaired short-term and long-term recognition, and long-term aversive memories...
July 8, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28681938/%C3%AF-hydroxyundec-9-enoic-acid-induces-apoptosis-by-ros-mediated-jnk-and-p38-phosphorylation-in-breast-cancer-cell-lines
#6
Joungjwa Ahn, Youn Wook Chung, Jin-Byung Park, Kyung Mi Yang
ω-Hydroxyundec-9-enoic acid (ω-HUA), a plant secondary metabolite, exhibits anti-fungal activity. However, its effect on breast cancer cells is unknown. Here, we investigated the anti- breast cancer activity of ω-HUA and its underlying mechanism. Treatment of human breast cancer cell lines, MDA-MB-231 and MDA-MB-435, with ω-HUA induced apoptotic cell death with increased cleaved caspase-3 and poly (ADP-ribose) polymerase (PARP) levels, and p38 and JNK phosphorylation. Inhibition of these mitogen-activated protein kinase (MAPK) pathways using specific inhibitors or siRNA, for p38 and JNK, respectively, blocked the ω-HUA-induced apoptosis in a dose-dependent manner...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28619064/protective-effect-of-rutin-supplementation-against-cisplatin-induced-nephrotoxicity-in-rats
#7
Ali R Alhoshani, Mohamed M Hafez, Sufia Husain, Abdel Malek Al-Sheikh, Moureq R Alotaibi, Salim S Al Rejaie, Musaad A Alshammari, Mashal M Almutairi, Othman A Al-Shabanah
BACKGROUND: Cisplatin (CP) is commonly used in the treatment of different types of cancer but nephrotoxicity has been a major limiting factor. Therefore, the present study aimed to study the possible protective effect of rutin against nephrotoxicity induced by cisplatin in rats. METHODS: Forty male Wistar albino rats were randomly divided into 4 groups. Rats of group 1 control group intraperitoneal (i.p.) received 2.5 ml/kg, group 2 CP group received single dose 5 mg/kg cisplatin i...
June 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28585748/effects-of-curcumin-on-tobacco-smoke-induced-hepatic-mapk-pathway-activation-and-epithelial-mesenchymal-transition-in-vivo
#8
Zhaofeng Liang, Rui Wu, Wei Xie, Chunfeng Xie, Jieshu Wu, Shanshan Geng, Xiaoting Li, Mingming Zhu, Weiwei Zhu, Jianyun Zhu, Cong Huang, Xiao Ma, Wenrong Xu, Caiyun Zhong, Hongyu Han
Tobacco smoke is a major risk factor for hepatic cancer. Epithelial-mesenchymal transition (EMT) induced by tobacco smoke is crucially involved in the initiation and development of cancer. Mitogen-activated protein kinase (MAPK) pathways play important roles in tobacco smoke-associated carcinogenesis including EMT process. The chemopreventive effect of curcumin supplementation against cancers has been reported. In this study, we investigated the effects of tobacco smoke on MAPK pathway activation and EMT alterations, and then the preventive effect of curcumin was examined in the liver of BALB/c mice...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28559210/cinnamaldehyde-in-diabetes-a-review-of-pharmacology-pharmacokinetics-and-safety
#9
REVIEW
Ruyuan Zhu, Haixia Liu, Chenyue Liu, Lili Wang, Rufeng Ma, Beibei Chen, Lin Li, Jianzhao Niu, Min Fu, Dongwei Zhang, Sihua Gao
Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent advances of cinnamaldehyde in its glucolipid lowering effects, its pharmacokinetics, and its safety by consulting the Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, National Science and Technology Library, Wanfang Data, and the Web of Science Databases...
May 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28546532/regulation-of-c-jun-n-terminal-protein-kinase-jnk-pathway-in-apoptosis-of-endothelial-outgrowth-cells-induced-by-asymmetric-dimethylarginine
#10
Fu-Qing Zhang, Wei Lu, Wen-Xiao Yuan, Xin Li
BACKGROUND Endothelial outgrowth cells (EOCs) are terminal endothelial progenitor cells (EPCs). Asymmetric dimethylarginine (ADMA) has been identified as a novel risk factor for cardiovascular diseases. Our aim in the present study was to investigate the effect of regulation of asymmetric dimethylarginine (ADMA) on EOCs apoptosis and to explore the underlining mechanisms of c-Jun N-terminal protein kinase (JNK) pathway in the process. MATERIAL AND METHODS EOCs were harvested from umbilical cord blood and obtained by using density gradient centrifugation and adhesive culture methods...
May 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28522560/effect-of-long-term-maternal-smoking-on-the-offspring-s-lung-health
#11
Surpon Sukjamnong, Yik Lung Chan, Razia Zakarya, Sonia Saad, Pawan Sharma, Rachana Santiyanont, Hui Chen, Brian G Oliver
Maternal smoking during pregnancy contributes to long-term health problems in offspring, especially respiratory disorders that can manifest in either childhood or adulthood. Receptors for advanced glycation end products (RAGE) are multiligand receptors abundantly localized in the lung, capable of responding to by-products of reactive oxygen species and proinflammatory responses. RAGE signaling is a key regulator of inflammation in cigarette smoking-related pulmonary diseases. However, the impact of maternal cigarette smoke exposure on lung RAGE signaling in the offspring is unclear...
August 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28503189/eicosapentaenoic-acid-shows-anti-inflammatory-effect-via-gpr120-in-3t3-l1-adipocytes-and-attenuates-adipose-tissue-inflammation-in-diet-induced-obese-mice
#12
Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-Ichi Momomura, Masanobu Kawakami, San-E Ishikawa, Kazuo Hara
BACKGROUND: Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrophages. However, the anti-inflammatory effects of unsaturated fatty acids in adipocytes have yet to be elucidated. Hence, the aims of the present study were to evaluate the anti-inflammatory effects of eicosapentaenoic acid (EPA) via GPR120 in adipocytes. METHODS: We used 250 μM palmitate as a representative saturated fatty acid...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28471490/hydroxyeicosapentaenoic-acids-and-epoxyeicosatetraenoic-acids-attenuate-early-occurrence-of-nonalcoholic-fatty-liver-disease
#13
Chunjiong Wang, Wenli Liu, Liu Yao, Xuejiao Zhang, Xu Zhang, Chenji Ye, Hongfeng Jiang, Jinlong He, Yi Zhu, Ding Ai
BACKGROUND AND PURPOSE: The ω-3 polyunsaturated fatty acids (PUFAs) mediate protective effects on several metabolic disorders. However, the functions of their metabolites in the early stage of nonalcoholic fatty liver disease (NAFLD) are largely unknown. EXPERIMENTAL APPROACH: Mice were fed a control diet, high-fat diet (HFD) or ω-3 PUFA-enriched HFD (ω3HFD) for 4 days and phenotypes were analysed. LC-MS/MS was used to determine the eicosanoid profiles. Primary hepatocytes and peritoneal macrophages were used for the mechanism study...
July 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28464236/neuroprotection-by-plumbagin-involves-bdnf-trkb-pi3k-akt-and-erk1-2-jnk-pathways-in-isoflurane-induced-neonatal-rats
#14
Jun-Hui Yuan, Feng Pan, Jie Chen, Cai-Er Chen, Deng-Pan Xie, Xing-Zhu Jiang, Su-Juan Guo, Jun Zhou
OBJECTIVES: This study was designed to assess the effects of plumbagin on isoflurane-induced neurotoxicity. METHODS: Neonatal Sprague Dawley rat pups were treated with plumbagin (50, 100 or 150 mg/kg body weight, orally) from postnatal day 2. The pups on postnatal day 7 were subjected to isoflurane (0.75%) exposure for 6 h. Neuronal apoptosis in the hippocampal tissues was detected by TUNEL assay and FluroJade B staining following isoflurane exposure. Protein expressions were analysed by immunoblotting...
May 2, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28420111/plantago-asiatica-l-ameliorates-puromycin-aminonucleoside-induced-nephrotic-syndrome-by-suppressing-inflammation-and-apoptosis
#15
Min Chul Kho, Ji Hun Park, Byung Hyuk Han, Rui Tan, Jung Joo Yoon, Hye Yoom Kim, You Mee Ahn, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
OBJECTIVE: Nephrotic syndrome, a kidney disease with a variety of causes, is mainly characterized by heavy proteinuria, hypoproteinemia, and ascites. This study was designed to evaluate the underlying mechanism of action of Plantago asiatica L. (PAL) in treating nephrotic syndrome induced by puromycin aminonucleoside. METHODS: PAL has been used in Asia as a traditional medicine and dietary health supplement. Sprague-Dawley (SD) rats were intravenously injected with puromycin aminonucleoside (75 mg/kg/day), then treated with either Losartan (30 mg/kg/day) or PAL (200 mg/kg/day) by oral gavage for seven days...
April 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28411010/effects-of-vitamin-d-and-resveratrol-on-metabolic-associated-markers-in-liver-and-adipose-tissue-from-samp8-mice
#16
Yehua Rui, Jinbo Cheng, Liqiang Qin, Cheng Shan, Jie Chang, Guiping Wang, Zhongxiao Wan
SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES: We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combination of vitamin D (VD) with resveratrol (RSV) will affect aging associated metabolic impairment in liver and adipose tissue from SAMP8 mice. METHODS: SAMP8 mice and their control SAMR1 mice were divided into 5 groups, i...
July 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28377722/curcumin-improves-palmitate-induced-insulin-resistance-in-human-umbilical-vein-endothelial-cells-by-maintaining-proteostasis-in-endoplasmic-reticulum
#17
Mao Ye, Hong Qiu, Yingkang Cao, Min Zhang, Yan Mi, Jing Yu, Changhua Wang
Dysfunction of proteasome and autophagy will result in disturbance of endoplasmic reticulum (ER) proteostasis, and thus lead to long-term and chronic ER stress and subsequent unfolded protein response (UPR), which is implicated in the occurrence and development of insulin resistance. Curcumin exerts beneficial metabolic effects in in vitro cells and in vivo animal models of diabetes and diabetic complications including cardiovascular diseases, due to its powerful anti-oxidative and anti-inflammatory properties...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28282614/inhibition-of-drp1-protects-against-senecionine-induced-mitochondria-mediated-apoptosis-in-primary-hepatocytes-and-in-mice
#18
Xiao Yang, Hua Wang, Hong-Min Ni, Aizhen Xiong, Zhengtao Wang, Hiromi Sesaki, Wen-Xing Ding, Li Yang
Pyrrolizidine alkaloids (PAs) are a group of compounds found in various plants and some of them are widely consumed in the world as herbal medicines and food supplements. PAs are potent hepatotoxins that cause irreversible liver injury in animals and humans. However, the mechanisms by which PAs induce liver injury are not clear. In the present study, we determined the hepatotoxicity and molecular mechanisms of senecionine, one of the most common toxic PAs, in primary cultured mouse and human hepatocytes as well as in mice...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28255652/attenuation-of-liver-cancer-development-by-oral-glycerol-supplementation-in-the-rat
#19
Alejo M Capiglioni, Florencia Lorenzetti, Ariel D Quiroga, Juan P Parody, María T Ronco, Gerardo B Pisani, María C Carrillo, María P Ceballos, María de Luján Alvarez
PURPOSE: Glycerol usage is increasing in food industry for human and animal nutrition. This study analyzed the impact of glycerol metabolism when orally supplemented during the early stage of rat liver carcinogenesis. METHODS: Wistar rats were subjected to a 2-phase model of hepatocarcinogenesis (initiated-promoted, IP group). IP animals also received glycerol by gavage (200 mg/kg body weight, IPGly group). RESULTS: Glycerol treatment reduced the volume of preneoplastic lesions by decreasing the proliferative status of liver foci, increasing the expression of p53 and p21 proteins and reducing the expression of cyclin D1 and cyclin-dependent kinase 1...
March 2, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28246130/nicotinamide-mononucleotide-an-nad-precursor-rescues-age-associated-susceptibility-to-aki-in-a-sirtuin-1-dependent-manner
#20
Yi Guan, Su-Rong Wang, Xin-Zhong Huang, Qiong-Hong Xie, Yun-Yu Xu, Da Shang, Chuan-Ming Hao
The rapid growth of an aging population creates challenges regarding age-related diseases, including AKI, for which both the prevalence and death rate increase with age. The molecular mechanism by which the aged kidney becomes more susceptible to acute injury has not been completely elucidated. In this study, we found that, compared with the kidneys of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD(+) Supplementation with nicotinamide mononucleotide (NMN), an NAD(+) precursor, restored renal SIRT1 activity and NAD(+) content in 20-month-old mice and further increased both in 3-month-old mice...
August 2017: Journal of the American Society of Nephrology: JASN
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