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vitamin D and hypertension

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https://www.readbyqxmd.com/read/29158563/vitamin-d-missing-link-between-hypertension-and-muscle-mass
#1
EDITORIAL
Maja Baretić, Martina Matovinović, Tea Vukić, Darjan Ranilović
No abstract text is available yet for this article.
November 20, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29135923/the-association-between-serum-25-oh-d-status-and-blood-pressure-in-participants-of-a-community-based-program-taking-vitamin-d-supplements
#2
Naghmeh Mirhosseini, Hassanali Vatanparast, Samantha M Kimball
BACKGROUND: Vitamin D deficiency is a risk factor for hypertension. METHODS: We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry...
November 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29133192/maternal-micronutrients-omega-3-fatty-acids-and-gene-expression-of-angiogenic-and-inflammatory-markers-in-pregnancy-induced-hypertension-rats
#3
Nisha Kemse, Deepali Sundrani, Anvita Kale, Sadhana Joshi
BACKGROUND AND AIMS: Preeclampsia is a disorder of pregnancy and is associated with inflammation and altered angiogenesis. The present study examines the effect of micronutrient and omega-3 fatty acid supplementation (individual, as well as combined) on genes involved in inflammation and angiogenesis, as well as global DNA methylation levels in a pregnancy induced hypertension (PIH) rat model. METHODS: Pregnant Wistar rats were randomly assigned to six dietary groups: control, PIH (Pregnancy induced hypertension) Induced; PIH Induced with micronutrient supplements with vitamin B12 (PIHB), folate (PIHF), omega-3 fatty acid (PIHO), and combined supplementation (PIHC) (micronutrients and omega-3 fatty acids)...
November 10, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29124703/vitamin-d-cardiovascular-disease-and-risk-factors
#4
Tea Skaaby, Betina H Thuesen, Allan Linneberg
Observational studies have suggested a possible protective role of vitamin D on the cardiovascular system. The available evidence does not support either cardiovascular benefits or harms of vitamin D supplementation. This chapter provides an overview and discussion of the current knowledge of vitamin D effects from a cardiovascular health perspective. It focuses on vitamin D in relation to cardiovascular disease, i.e. ischemic heart disease, and stroke; the traditional cardiovascular risk factors hypertension, abnormal blood lipids, obesity; and the emerging risk factors hyperparathyroidism, microalbuminuria, chronic obstructive pulmonary diseases, and non-alcoholic fatty liver disease...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29122812/nebivolol-but-not-metoprolol-treatment-improves-endothelial-fibrinolytic-capacity-in-adults-with-elevated-blood-pressure
#5
Brian L Stauffer, Caitlin A Dow, Kyle J Diehl, Tyler D Bammert, Jared J Greiner, Christopher A DeSouza
BACKGROUND: Vascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β-blockers on endothelial fibrinolysis is unknown. This study compared the effects of chronic nebivolol and metoprolol treatment on endothelial tissue-type plasminogen activator (t-PA) release in adults with elevated blood pressure (BP). METHODS AND RESULTS: Forty-four middle-aged adults (36% women) with elevated BP completed a 3-month, double-blind, randomized, placebo-controlled trial comparing nebivolol (5 mg/d), metoprolol succinate (100 mg/d), and placebo...
November 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29114197/low-levels-of-vitamin-d-an-emerging-risk-for-cardiovascular-diseases-a-review
#6
REVIEW
Farrukh Majeed
Sunlight is regarded among greatest gifts that are presented in abundance to the human beings from the God. Sunlight is also a rich source of Vitamin D (Vit D) that prevents us from numerous ailments such as autoimmune disorders, various types of cancer, and the above all cardiovascular diseases (CVD). Evident from recent research that Vit D deficiency may be the cause for hypertension, cardiac autonomic imbalance, vascular endothelial dysfunction, metabolic syndrome, and even diabetes. Concurrently, many studies present research outcomes that are contradictory to earlier results and also raised a concern not for general public but also among their treating physicians...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29102596/assessment-of-novel-cardiovascular-biomarkers-in-women-with-a-history-of-recurrent-miscarriage
#7
M M Wagner, J W Jukema, W Hermes, S le Cessie, C J M de Groot, J A Bakker, J M M van Lith, K W M Bloemenkamp
OBJECTIVES: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. STUDY DESIGN: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-up study (between 2012 and 2014)...
October 28, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29093562/glucocorticoid-exposure-induces-preeclampsia-via-dampening-1-25-dihydroxyvitamin-d3
#8
Dongxin Zhang, Ji Zeng, Xili Miao, Haojing Liu, Liangfang Ge, Wei Huang, Jinyu Jiao, Duyun Ye
The pathogenesis of preeclampsia (PE) involves a number of biological processes that may be directly or indirectly affected by glucocorticoid (GC) and vitamin D. GC exposure increases the risk of PE, and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) deficiency may result in PE. The purpose of the present study was to confirm the involvement of GC/1,25-(OH)2D3 axis in the pathogenesis of PE. In the study, cortisol levels of PE patients were found to be higher than that of non-complicated pregnancies, while 1,25-(OH)2D3 were decreased in both PE women and GC-induced PE rats...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29089365/cardiometabolic-healthy-and-unhealthy-obesity-does-vitamin-d-play-a-role
#9
Eliana Piantanida, Daniela Gallo, Giovanni Veronesi, Eugenia Dozio, Eugenia Trotti, Adriana Lai, Silvia Ippolito, Jessica Sabatino, Maria Laura Tanda, Antonio Toniolo, Marco Ferrario, Luigi Bartalena
The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. Design and methods One-hundred-ninety-six consecutive patients (152 women; mean age 51±13 years) with visceral obesity [mean body weight 103±20 Kg, mean waist circumference (WC) 119±13 cm] were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D [25(OH)D)], fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed...
October 31, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29083435/dairy-intakes-in-older-irish-adults-and-effects-on-vitamin-micronutrient-status-data-from-the-tuda-study
#10
E Laird, M C Casey, M Ward, L Hoey, C F Hughes, K McCarroll, C Cunningham, J J Strain, H McNulty, A M Molloy
BACKGROUND: Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for health in older adults is three servings per day but recent analysis of the NHANES data for older adults reported 98% were not meeting these recommendations. No studies have investigated the consequences of such declines in the dairy intakes of Irish older adults and the subsequent effects on vitamin micronutrient status...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29080634/role-of-vitamin-d-in-cardiovascular-diseases
#11
REVIEW
Vikrant Rai, Devendra K Agrawal
Vitamin D is critical in mineral homeostasis and skeletal health and plays a regulatory role in nonskeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity, both strong risk factors for cardiovascular diseases (CVDs). CVDs, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality...
December 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29064176/calciphylaxis-after-parathyroidectomy
#12
Sathish Karmegam, Anupkumar Shetty
A 60-year-old African American man with end stage renal disease on hemodialysis (HD) for the past 2.5 years developed severe hyperparathyroidism. Other past medical history included atrial fibrillation, type II diabetes mellitus, hypertension, gout, pericardial effusion needing pericardial window, deep vein thrombosis, mitral insufficiency, and cardiomyopathy with implantable cardioversion device placement. His parathyroid hormone (PTH) level peaked at 4,191 pg/mL despite being on cinacalcet, sevelamer, and paricalcitol...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29057843/calcium-and-vitamin-d-supplementation-for-prevention-of-preeclampsia-a-systematic-review-and-network-meta-analysis
#13
REVIEW
Win Khaing, Sakda Arj-Ong Vallibhakara, Visasiri Tantrakul, Orawin Vallibhakara, Sasivimol Rattanasiri, Mark McEvoy, John Attia, Ammarin Thakkinstian
Vitamin D supplementation effects with or without calcium in pregnancy for reducing risk of preeclampsia and gestational or pregnancy induced hypertension are controversial. Literature was systematically searched in Medline, Scopus and Cochrane databases from inception to July 2017. Only randomized controlled trials (RCTs) in English were selected if they had any pair of interventions (calcium, vitamin D, both, or placebo). Systematic review with two-step network-meta-analysis was used to indirectly estimate supplementary effects...
October 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29055500/long-term-systemic-corticosteroid-exposure-a-systematic-literature-review
#14
REVIEW
J Bradford Rice, Alan G White, Lauren M Scarpati, George Wan, Winnie W Nelson
PURPOSE: While corticosteroids are relatively inexpensive and commonly used as treatment for a variety of conditions, long-term use is known to be associated with certain toxicities. Prior systematic reviews have revealed an increased risk for costly adverse events (AEs), including bone fracture, infection, and gastrointestinal bleeding. The objective of this study was to conduct a systematic literature review of recent publications on the burden of long-term corticosteroid exposure, specifically, to summarize the AEs and economic impact of long-term corticosteroid use and to reveal data gaps for additional research...
October 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29046405/potato-consumption-does-not-increase-blood-pressure-or-incident-hypertension-in-2-cohorts-of-spanish-adults
#15
Emily A Hu, Miguel A Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Antonio Garcia-Rodriguez, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Cristina Razquin, Mònica Bulló, José V Sorlí, Helmut Schröder, Casey M Rebholz, Estefania Toledo
Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension.Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations.Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means ± SDs) of 42...
October 18, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29042901/vitamin-d-and-hypertension
#16
REVIEW
Hye Yun Jeong, Kyung Mi Park, Mi Jung Lee, Dong Ho Yang, Sang Hoon Kim, So-Young Lee
Vitamin D has the pleiotropic effects in multiple organ systems, and vitamin D deficiency was suggested to be associated with high blood pressure according to previous reports. Several interventional studies have examined the effect of vitamin D supplementation on high blood pressure patients, but the results have been inconsistent. In this article, we examined the literature that have proposed a mechanism involving vitamin D in the regulation of blood pressure and review previous observational and interventional studies that have shown the relationship between vitamin D and hypertension among various populations...
September 2017: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/29041890/-effect-of-cholecalciferol-and-diuretics-as-components-of-combination-antihypertensive-therapy-on-plasma-renin-activity-and-endothelial-function-in-patients-with-arterial-hypertension
#17
V L Yankouskaya, A V Snezhitskiy, N M Mamedov
AIM: To evaluate the effect of cholecalciferol and diuretics as components of combination antihypertensive therapy (CAHT) on plasma renin activity (PRA) and endothelial function in patients with arterial hypertension (AH). MATERIALS AND METHODS: We included in this prospective study 153 patients with II-degree AH. Duration of follow-up was 15.8±1.8 months. Patients were divided into four groups: patients of group 0 received CAHT without cholecalciferol or diuretic; of group 1 - CAHT with cholecalciferol (2000 IU daily); of group 2 - CAHT with diuretic; of group 3 - CAHT with diuretic and cholecalciferol 2000 IU daily...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/28993865/two-year-cortical-and-trabecular-bone-loss-in-ckd-5d-biochemical-and-clinical-predictors
#18
H H Malluche, M-C Monier-Faugere, G Blomquist, D L Davenport
This prospective two-year study of patients on chronic dialysis measured changes in bone mineral density (BMD). Patients with higher baseline BMD and shorter dialysis vintage lost more bone. Treatment with anti-hypertensives acting on the central nervous system was protective against bone loss. Baseline serum levels of sclerostin and bone-specific alkaline phosphatase predicted bone loss. INTRODUCTION: This prospective 2-year study of chronic kidney disease on dialysis (CKD-5D) patients assessed trabecular and cortical bone loss at the hip and spine and examined potential demographic, clinical, and serum biochemical predictors of bone loss...
October 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28981319/vitamin-d-supplementation-prevents-placental-ischemia-induced-endothelial-dysfunction-by-downregulating-placental-soluble-fms-like-tyrosine-kinase-1
#19
Su-Ling Ma, Xiao-Yu Tian, Ya-Qi Wang, Hui-Feng Zhang, Lei Zhang
Maternal vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. Vascular endothelial dysfunction is a major phenotype of pregnancies with preeclampsia, contributing to increased maternal hypertension and proteinuria. We sought to determine whether vitamin D supplementation would alleviate preeclampsia associated endothelial dysfunction and explore the underlying mechanism using the reduced uterine perfusion pressure (RUPP) rat model. RUPP operated rats were supplemented with 1,25(OH)2D (RUPP+VD) on day 1, 7, and 14 of pregnancy by subcutaneous injection...
October 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28975092/self-limited-membranous-nephropathy-after-intravitreal-bevacizumab-therapy-for-age-related-macular-degeneration
#20
Gebran Khneizer, Ahmad Al-Taee, Bahar Bastani
BACKGROUND: Monoclonal antibodies targeting vascular endothelial growth factor (VEGF), such as bevacizumab, are administered intravitreally for the treatment of wet or exudative age-related macular degeneration (ARMD). Systemic use of bevacizumab has been linked to a wide range of renal adverse effects including proteinuria and hypertension. CASE PRESENTATION: We present the case of a 77-year-old Caucasian male with a past medical history of hypertension, vitamin D deficiency and paroxysmal atrial fibrillation who presented to primary care clinic with a 2-week history of bilateral lower extremity edema, 2 months after completing four monthly intravitreal injections of bevacizumab for ARMD...
July 2017: Journal of Nephropathology
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