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hypothermia elderly

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https://www.readbyqxmd.com/read/29662269/two-siblings-with-congenital-central-hypothyroidism-caused-by-a-novel-mutation-in-the-igsf1-gene
#1
Makiko Oguma, Mizuki Kobayashi, Masayo Yamazaki, Koji Yokoyama, Shuntaro Morikawa, Takeshi Yamaguchi, Takanori Yamagata, Toshihiro Tajima
Genetic defects in the immunoglobulin superfamily member 1(IGSF1) protein are the cause of congenital central hypothyroidism (C-CH). Here we report two Japanese siblings with C-CH due to a novel IGSF1 mutation. The youngest brother showed a failure to thrive, hypothermia, and neonatal icterus six days after birth. Further endocrine evaluations led to the diagnosis of C-CH. In addition, PRL deficiency was later detected. In contrast, the elder brother did not show symptoms of severe hypothyroidism during the neonatal period, but he had been followed up by doctors due to psychomotor developmental delays since the age of 1 yr...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29518256/homicide-in-a-horse-barn
#2
Samuel P Prahlow, Joseph A Prahlow
As forensic scientists and physicians, forensic pathologists are duty-bound to perform their examinations with integrity and professionalism. The practice of medicine requires knowledge regarding the history and presentation of the patient. In forensic pathology, the history includes scene and other investigative information, and the decedent's medical and social history. Such information is important for the correct certification of the cause and manner of death. Herein, the authors present a case originally thought by police and death investigators to represent a sexual-assault-related homicide, as an elderly female's body was found partially nude, and apparently beaten, on the muddy floor of her horse barn...
March 8, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29286319/cellular-and-molecular-mechanisms-underlying-non-pharmaceutical-ischemic-stroke-therapy-in-aged-subjects
#3
REVIEW
Raluca Elena Sandu, Danut Dumbrava, Roxana Surugiu, Daniela-Gabriela Glavan, Andrei Gresita, Eugen Bogdan Petcu
The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29197846/severe-recurrent-hypothermia-in-an-elderly-patient-with-refractory-mania-associated-with-atypical-antipsychotic-valproic-acid-and-oxcarbazepine-therapy
#4
Oluwadamilare O Ajayi, Suzanne Holroyd
Hypothermia is a rare but serious condition that has been associated with various psychiatric medications. We present a 76-year-old woman with refractory mania who developed multiple episodes of severe hypothermia associated with several psychiatric medications including olanzapine, quetiapine, valproic acid and oxcarbazepine. These episodes resolved following discontinuation of the agents. The patient had never experienced hypothermia before, despite having been on these or similar agents for many years. With traditional treatments for mania not feasible, other medications were used to treat her including lithium, clonazepam, gabapentin and the novel protein kinase c inhibitor tamoxifen...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29070019/a-95-year-old-suffering-circulatory-arrest-after-accidental-hypothermia-a-case-report
#5
Anders Wetting Carlsen, Anders M Winnerkvist, Guri Greiff
BACKGROUND: The elderly are vulnerable to cold and prone to accidental hypothermia, both because of environmental and endogenous factors. The incidence of severe accidental hypothermia among the elderly is poorly described, but many cases probably go unrecorded. Going through literature one finds few publications on severe hypothermia among the elderly, and, to our knowledge, nothing about extracorporeal re-warming of geriatric hypothermia victims. CASE PRESENTATION: We present a case were a 95 year-old man with severe accidental hypothermia and circulatory arrest was brought to our hospital under on-going CPR, and was successfully resuscitated with extracorporeal circulation...
October 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28825577/-myxedema-coma
#6
Leonardo F L Rizzo, Daniela L Mana, Oscar D Bruno, Leonard Wartofsky
Hypothyroidism is a frequently diagnosed and simply treated disease. If not recognised, however, in time it may develop into the most severe manifestation of hypothyroidism known as myxedema coma. The term "myxedema coma" is generally seen as misleading since most patients do not initially present in a coma. The typical progression is lethargy evolving into stupor and, eventually, into coma with respiratory failure and hypothermia. It mainly affects elderly women, often occurring in winter and is relatively rare...
2017: Medicina
https://www.readbyqxmd.com/read/28807442/age-is-related-to-neurological-outcome-in-patients-with-out-of-hospital-cardiac-arrest-ohca-receiving-therapeutic-hypothermia-th
#7
Se Jong Oh, Jin Joo Kim, Jae Ho Jang, In Cheol Hwang, Jae Hyuk Woo, Yong Su Lim, Hyuk Jun Yang
INTRODUCTION: In this study, we retrospectively reviewed the patients' outcomes after cardiac arrest based on age in one center, to determine whether geriatric patients had worse outcomes. METHODS: This was a single-center, retrospective cohort study. The patients admitted to the intensive care unit on successful resuscitation after OHCA were retrospectively identified and evaluated. RESULTS: This was a retrospective cohort study of patients over 18years of-age with return of spontaneous circulation (ROSC) (>24h) after cardiac arrest who were admitted to the emergency intensive care unit (EICU) and received post-cardiac arrest care between March 2007 and December 2013...
February 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28766264/acetaminophen-paracetamol-induces-hypothermia-during-acute-cold-stress
#8
Josh Foster, Alexis R Mauger, Andrew Govus, David Hewson, Lee Taylor
BACKGROUND: Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (Tc ) in the absence of fever. However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen is exacerbated with cold exposure. OBJECTIVE: To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and thermal neutrality (25 °C)...
November 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28540093/myxedema-crisis-presenting-with-seizures-a-rare-life-threatening-presentation-a-case-report-and-review-of-the-literature
#9
Sonali Sihindi Chapa Gunatilake, Uditha Bulugahapitiya
Myxedema crisis is a life-threatening extreme form of hypothyroidism with a high mortality rate if left untreated. Myxedema crisis is commonly seen in older patients, especially in women, and is associated with signs of hypothyroidism, hypothermia, hyponatraemia, hypercarbia, and hypoxemia. Patients might present with different organ specific symptoms. Seizures are a recognized but rare manifestation of myxedema with a very high mortality rate. Prompt diagnosis and appropriate management may improve the prognosis...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28353593/warming-infusion-improves-perioperative-outcomes-of-elderly-patients-who-underwent-bilateral-hip-replacement
#10
RANDOMIZED CONTROLLED TRIAL
He Ma, Bingjie Lai, Shanshan Dong, Xinyu Li, Yunfeng Cui, Qianchuang Sun, Wenhua Liu, Wei Jiang, Feng Xu, Hui Lv, Hongyu Han, Zhenxiang Pan
BACKGROUND: This prospective, randomized, and controlled study was performed to determine the benefits of prewarmed infusion in elderly patients who underwent bilateral hip replacement. METHODS: Between September 2015 and April 2016, elderly patients who underwent bilateral hips replacement that met the inclusion and exclusion criteria were included in this study. After inclusion, patients were randomized into one of the study groups: in the control group, patients received an infusion of fluid kept at room temperature (22-23°C); in the warming infusion group, patients received an infusion of fluid warmed using an infusion fluid heating apparatus (35°C)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205299/perioperative-hypothermia-during-hip-fracture-surgery-an-observational-study
#11
Usha Gurunathan, Christopher Stonell, Paul Fulbrook
RATIONALE: Elderly patients are at high risk of accidental perioperative hypothermia. The primary objective of this study was to measure the changes in body temperature and the incidence of hypothermia in elderly patients undergoing hip fracture surgery. METHODS: We conducted a prospective observational study on all adult patients undergoing surgery for fractured neck of femur between December 2013 and July 2014. We monitored their temperatures in different perioperative areas at multiple time points and also noted the warming methods used...
August 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27488978/extended-use-of-hypothermia-in-elderly-patients-with-malignant-cerebral-edema-as-an-alternative-to-hemicraniectomy
#12
Han-Yeong Jeong, Jun-Young Chang, Kyu Sun Yum, Jeong-Ho Hong, Jin-Heon Jeong, Min-Ju Yeo, Hee-Joon Bae, Moon-Ku Han, Kiwon Lee
BACKGROUND AND PURPOSE: The use of decompressive hemicraniectomy (DHC) for the treatment of malignant cerebral edema can decrease mortality rates. However, this benefit is not sufficient to justify its use in elderly patients. We investigated the effects of therapeutic hypothermia (TH) on safety, feasibility, and functional outcomes in elderly patients with malignant middle cerebral artery (MCA) infarcts. METHODS: Elderly patients 60 years of age and older with infarcts affecting more than two-thirds of the MCA territory were included...
September 2016: Journal of Stroke
https://www.readbyqxmd.com/read/27475011/geriatric-trauma
#13
REVIEW
Casper Reske-Nielsen, Ron Medzon
Within the next 15 years, 1 in 5 Americans will be over age 65. $34 billion will be spent yearly on trauma care of this age group. This section covers situations in trauma unique to the geriatric population, who are often under-triaged and have significant injuries underestimated. Topics covered include age-related pathophysiological changes, underlying existing medical conditions and certain daily medications that increase the risk of serious injury in elderly trauma patients. Diagnostic evaluation of this group requires liberal testing, imaging, and a multidisciplinary team approach...
August 2016: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/27227069/temperature-and-toxic-tau-in-alzheimer-s-disease-new-insights
#14
REVIEW
Daniel Carneiro Carrettiero, Fernando Enrique Santiago, Anna Carolina Parracho Motzko-Soares, Maria Camila Almeida
Alzheimer's disease (AD), the most common dementia in the elderly, is characterized by cognitive impairment and severe autonomic symptoms such as disturbance in core body temperature (Tc), which may be predictors or early events in AD onset. Inclusions of phosphorylated Tau (p-Tau) are a hallmark of AD and other neurodegenerative disorders called "Tauopathies." Animal and human studies show that anesthesia augments p-Tau levels through reduction of Tc, with implications for AD. Additionally, hypothermia impairs memory and cognitive function...
October 2015: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27160113/effect-of-perioperative-inadvertent-hypothermia-on-the-ecg-parameters-in-patients-undergoing-transurethral-resection
#15
H Bayir, I Yildiz, F Erdem, U Y Tekelioglu, M E Ozyalvacli, M Bilgi, H Kocoglu
OBJECTIVE: Perioperative inadvertent hypothermia (PIH) (core body temperature to < 36 °C) is a common event during surgery. PIH may result from multiple factors. Elderly urology patients are at greater risk than other patients for hypothermia. PIH may cause adverse postoperative cardiac clinical manifestations. Our study aimed to determine the effects of postoperative alteration of core body temperature on the ECG parameters in patients undergoing transurethral resection. PATIENTS AND METHODS: Fifty-nine patients, 40-83 years of age, who were scheduled for elective Transurethral Resection Prostate and/or Bladder (TUR-P and/or TUR-B) were enrolled in the study...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27111243/a-descriptive-analysis-of-therapeutic-hypothermia-application-across-adult-age-groups
#16
MULTICENTER STUDY
Timothy J Mader, Brian H Nathanson, Ryan A Coute, Bryan F McNally
Therapeutic hypothermia (TH) has been recommended for comatose adults recovering from out-of-hospital cardiac arrest (OHCA) for a decade. However, TH has never been evaluated in a randomized control trial in patients aged 75 or older. How the administration of TH varies across age groups experiencing an OHCA is unknown. The objective was to describe the use of TH across predefined age groups with an emphasis on geriatric OHCA survivors using data compiled through Cardiac Arrest Registry to Enhance Survival (CARES)...
August 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27111131/reversible-hypothermia-in-a-drug-naive-inpatient-with-alzheimer-s-disease-receiving-pipamperone
#17
D Kamp, M Paschali, C Lange-Asschenfeldt
Hypothermia is a potentially life-threatening side effect of antipsychotic drugs, especially those with strong 5-HT2 antagonist properties. However, the exact underlying mechanism is still under debate. We discuss a case of hypothermia following pipamperone treatment in an elderly female inpatient with Alzheimer's disease, which occurred at day 4 after medication onset and vanished after dose reduction. Thus, this case demonstrates 1) the importance of monitoring body temperature even in low-potency antipsychotics, at least in the elderly, and 2) that in some cases, dose reduction may be a sufficient countermeasure...
September 2016: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27069938/prognostic-implications-of-acute-renal-failure-after-surgery-for-type-a-acute-aortic-dissection
#18
Fabrizio Sansone, Alessandro Morgante, Fabrizio Ceresa, Giovanni Salamone, Francesco Patanè
BACKGROUND: "Type A" acute aortic dissection (AAAD) is the most challenging among the emergency operations in cardiac surgery. The aim of this study was the evaluation of the role of acute renal failure (ARF) in postoperative survival of patients operated for AAAD. METHODS: From February 2010 to April 2012, 37 consecutive patients were operated at our department for AAAD. We studied our population by subdividing the patients within groups according to the presence of ARF requiring continuous veno-venous hemofiltration (CVVH) and according to hypothermic circulatory arrest (HCA) times and degrees...
June 2015: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/26866849/effect-of-therapeutic-hypothermia-on-survival-and-neurologic-outcome-in-the-elderly
#19
Nichole E Bosson, Amy H Kaji, William J Koenig, James T Niemann
Old age is considered a negative prognostic factor after out-of-hospital cardiac arrest (OHCA). The purpose of this study was to assess the benefit of therapeutic hypothermia (TH) on survival and neurologic outcome in the elderly. This is a retrospective study of patients treated for OHCA from April 2011 to August 2013 in a regional cardiac system. Patients with return of spontaneous circulation (ROSC) are directed to designated cardiac receiving centers with established TH protocols. The decision to initiate TH is determined by the treating physician...
June 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/26857616/geographic-distribution-of-disaster-specific-emergency-department-use-after-hurricane-sandy-in-new-york-city
#20
David C Lee, Silas W Smith, Brendan G Carr, Kelly M Doran, Ian Portelli, Corita R Grudzen, Lewis R Goldfrank
OBJECTIVE: We aimed to characterize the geographic distribution of post-Hurricane Sandy emergency department use in administrative flood evacuation zones of New York City. METHODS: Using emergency claims data, we identified significant deviations in emergency department use after Hurricane Sandy. Using time-series analysis, we analyzed the frequency of visits for specific conditions and comorbidities to identify medically vulnerable populations who developed acute postdisaster medical needs...
June 2016: Disaster Medicine and Public Health Preparedness
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