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https://www.readbyqxmd.com/read/28025826/concurrent-use-of-continuous-and-pulsatile-flow-ventricular-assist-device-on-a-fontan-patient-a-simulation-study
#1
Arianna Di Molfetta, Gianfranco Ferrari, Roberta Iacobelli, Sergio Filippelli, Antonio Amodeo
The aim of this work is to develop and test a lumped parameter model of the cardiovascular system to simulate the concurrent use of pulsatile (PVAD) and continuous flow (CVAD) ventricular assist device (VAD) on Fontan patients. Echocardiographic and hemodynamic data of five Fontan patients were retrospectively collected and used to simulate the patients' baseline hemodynamics. Then, for each patient, the following assistance modality was simulated for the cavopulmonary and the single ventricle (SV): (a) CVAD for cavopulmonary assistance (RCF) and PVAD assisting the SV (LCF) (RPF + LCF), (b) CVAD assisting SV and PVAD for cavopulmonary assistance (LPF + RCF)...
December 26, 2016: Artificial Organs
https://www.readbyqxmd.com/read/28017353/significance-of-residual-mitral-regurgitation-after-continuous-flow-left%C3%A2-ventricular-assist-device-implantation
#2
Hayah Kassis, Krishna Cherukuri, Richa Agarwal, Manreet Kanwar, Subbarao Elapavaluru, George G Sokos, Robert J Moraca, Stephen H Bailey, Srinivas Murali, Raymond L Benza, Amresh Raina
OBJECTIVES: This study hypothesized that the presence of residual mitral regurgitation (MR) post-continuous flow (CF) left ventricular assist device (LVAD) implantation based on quantitative assessment would be negatively associated with right ventricular (RV) size and function and clinical outcomes. BACKGROUND: MR is associated with elevated left atrial pressure, secondary pulmonary hypertension and RV dysfunction. Implantation of a LVAD leads to mechanical unloading of the left ventricle and generally improves MR...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/28007868/systemic-right-ventricular-morphology-in-the-early-postoperative-course-after-extracardiac-fontan-operation-is-there-still-a-need-for-special-care
#3
Sarah Nordmeyer, Melanie Rohder, Johannes Nordmeyer, Oliver Miera, Björn Peters, Mi-Young Cho, Joachim Photiadis, Felix Berger, Stanislav Ovroutski
OBJECTIVES: We aimed to compare early postoperative outcome after extracardiac (EC) Fontan operation between patients with right (RV) or left (LV) systemic ventricles. METHODS: In total, 173 consecutive patients (median age 4 years, median weight 14 kg) underwent EC Fontan between 1995 and 2013. Pre- and intraoperative data as well as detailed postoperative haemodynamic variables were compared between patients with LV [n = 109 (63%)] and RV [n = 64 (37%)]...
December 22, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28003648/cardiac-structural-remodeling-in-hypertensive-cardiomyopathy
#4
Si-Jia Sun, Jia-Lu Yao, Lang-Biao Xu, Qing Rui, Nan-Nan Zhang, Min Chen, Yu-Feng Jiang, Hua-Jia Yang, Ya-Feng Zhou
Heart failure with preserved ejection fraction (HFpEF), which is a primary driver of morbidity and mortality, accounts for approximately half of all heart failure cases. Therefore, it is essential to develop preclinical animal models for HFpEF pharmacological treatment strategies. We created a porcine model of severe hypertension and hyperlipidemia by using a combination of deoxycorticosterone acetate (DOCA, 100 mg kg(-1)), Western diet (WD) and angiotensin II infusion. Systolic blood pressure, echocardiography and invasive pressure-volume loop were assessed at baseline, 12 weeks and 18 weeks...
December 22, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27999948/overestimation-by-echocardiography-of-the-peak-systolic-pressure-gradient-between-the-right-ventricle-and-right-atrium-due-to-tricuspid-regurgitation-and-the-usefulness-of-the-early-diastolic-transpulmonary-valve-pressure-gradient-for-estimating-pulmonary-artery
#5
Takuma Hioka, Sanae Kaga, Taisei Mikami, Kazunori Okada, Michito Murayama, Nobuo Masauzi, Masahiro Nakabachi, Hisao Nishino, Shinobu Yokoyama, Mutsumi Nishida, Hiroyuki Iwano, Mamoru Sakakibara, Satoshi Yamada, Hiroyuki Tsutsui
We investigated the influence of tricuspid regurgitation (TR) severity on the echocardiographic peak systolic transtricuspid pressure gradient (TRPG) and evaluated the usefulness of the peak early diastolic transpulmonary valve pressure gradient (PRPG) for estimating pulmonary artery (PA) pressure. In 55 consecutive right heart-catheterized patients, we measured the peak systolic right ventricular (RV)-right atrial (RA) pressure gradient (RV-RACATH), peak early diastolic PA-RV pressure gradient (PA-RVCATH), and mean PA pressure (MPAPCATH)...
December 20, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27987104/phenylephrine-increases-near-infrared-spectroscopy-determined-muscle-oxygenation-in-men
#6
H Sørensen, J H Thomsen, A S P Meyer, D Terzic, L Hilsted, J Kjærgaard, J P Goetze, T C Barbosa, N H Secher
Phenylephrine increases mean arterial pressure (MAP) by enhanced total peripheral resistance (TPR) but near-infrared spectroscopy (NIRS) determined muscle oxygenation (SmO2) increases. We addressed that apparent paradox during supine rest and head-up tilt (HUT). Variables were determined ± phenylephrine in males during supine rest (n = 17) and 40° HUT (n = 7). MAP, stroke volume (SV), heart rate (HR), and TPR were derived by Modelflow(®) and NIRS determined biceps SmO2 and (tibial) bone oxygenation (StibialO2)...
December 16, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27939353/three-dimensional-diastolic-blood-flow-in-the-left-ventricle
#7
Seyed Saeid Khalafvand, Eddie Yin-Kwee Ng, Liang Zhong, Tin-Kan Hung
Three-dimensional blood flow in a human left ventricle is studied via a computational analysis with magnetic resonance imaging of the cardiac motion. Formation, growth and decay of vortices during the myocardial dilation are analyzed with flow patterns on various diametric planes. They are dominated by momentum transfer during flow acceleration and deceleration through the mitral orifice. The posterior and anterior vortices form an asymmetric annular vortex at the mitral orifice, providing a smooth transition for the rapid inflow to the ventricle...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27932136/prognostic-value-of-high-sensitivity-troponin-t-to-identify-patients-at-risk-of-left-ventricular-graft-dysfunction-after-heart-transplantation
#8
A B Méndez, J Ordonez-Llanos, S Mirabet, J Galan, M L Maestre, V Brossa, M T Rivilla, L López, T Koller, A Sionis, E Roig
Primary graft dysfunction after heart transplantation (HTx) has a very high mortality rate, especially if the left ventricle (PGD-LV) is involved. Early diagnosis is important to select the appropriate therapy to improve prognosis. The value of high-sensitivity troponin T (HS-TNT) measurement obtained at patient arrival at the intensive care unit was analyzed in 71 HTx patients. Mild or moderate PGD-LV was defined by hemodynamic compromise with one of the following criteria: left ventricular ejection fraction <40%, hemodynamic compromise with right atrial pressure >15 mm Hg, pulmonary capillary wedge pressure >20 mm Hg, cardiac index <2...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27918847/left-ventricular-compressions-improve-hemodynamics-in-a-swine-model-of-out-of-hospital-cardiac-arrest
#9
Kenton L Anderson, Maria G Castaneda, Susan M Boudreau, Danny J Sharon, Vikhyat S Bebarta
INTRODUCTION: We hypothesized that chest compressions located directly over the left ventricle (LV) would improve hemodynamics, including coronary perfusion pressure (CPP), and return of spontaneous circulation (ROSC) in a swine model of cardiac arrest. METHODS: Transthoracic echocardiography (echo) was used to mark the location of the aortic root and the center of the left ventricle on animals (n = 26) which were randomized to receive chest compressions in one of the two locations...
December 5, 2016: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27904840/surgical-experience-on-chronic-constrictive-pericarditis-in-african-setting-review-of-35-years-experience-in-cote-d-ivoire
#10
Koffi Herve Yangni-Angate, Yves Tanauh, Christophe Meneas, Florent Diby, Anicet Adoubi, Manga Diomande
BACKGROUND: Surgical experience with chronic constrictive pericarditis (CCP) is rarely documented in Africa; the aim of this study is therefore to review our African experience with CCP from 1977 to 2012 in terms of clinical and surgical outcomes and risk factors of early death after pericardiectomy. METHODS: This retrospective study is related to 120 patients with CCP; there were 72 men and 48 women with an average age at 28.8±10.4 years standard deviation (SD) (8-51 years)...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27903393/-a-multi-center-study-on-the-long-term-mortality-and-related-risk-factors-in-patients-with-chronic-heart-failure-receiving-resynchronization-therapy
#11
S Y Qi, D M Wang, H B Yu, C Ding, F L Tian, L S Ru, J Li, B Zhang, Y L Han
Objective: To analyze long-term mortality and patients characteristics of cardiac resynchronization therapy (CRT) for patients with chronic heart failure. Methods: In-patients with chronic heart failure who received CRT in the three medical centers(Bethune International Peace Hospital, General Hospital of Shenyang Military Command of Chinese People's Liberation Army, and 251 Hospital of People's Liberation Army)from March 2001 to June 2013 were included.Mortality and related causes, echocardiographic parameters were analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27887729/valveless-pumping-mechanics-of-the-embryonic-heart-during-cardiac-looping-pressure-and-flow-through-micro-piv
#12
D L Bark, B Johnson, D Garrity, L P Dasi
Cardiovascular development is influenced by the flow-induced stress environment originating from cardiac biomechanics. To characterize the stress environment, it is necessary to quantify flow and pressure. Here, we quantify the flow field in a developing zebrafish heart during the looping stage through micro-particle imaging velocimetry and by analyzing spatiotemporal plots. We further build upon previous methods to noninvasively quantify the pressure field at a low Reynolds number using flow field data for the first time, while also comparing the impact of viscosity models...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27861290/pathophysiological-trends-during-withdrawal-of-life-support-implications-for-organ-donation-after-circulatory-death
#13
Arjun Iyer, Hong Chee Chew, Ling Gao, Jeanette Villanueva, Mark Hicks, Aoife Doyle, Gayathri Kumarasinghe, Andrew Jabbour, Paul Cassius Jansz, Michael P Feneley, Richard P Harvey, Robert M Graham, Kumud K Dhital, Peter S Macdonald
BACKGROUND: Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been limited by concern regarding the viability of DCD hearts. The aim of this study was to document the pathophysiological changes that occur in the heart and circulation during withdrawal of life (WLS) support...
December 2016: Transplantation
https://www.readbyqxmd.com/read/27845957/two-dimensional-speckle-tracking-echocardiography-based-left-atrial-strain-parameters-predict-masked-hypertension-in-patients-with-hypertensive-response-to-exercise
#14
Soe M Aung, Ahmet Güler, Yeliz Güler, Can Y Karabay, Ilyas Akdemir
OBJECTIVE: We aim to study left atrial (LA) strains in patients with hypertensive response to exercise (HRE) and determine their usefulness in predicting masked hypertension (HT). METHODS: Ninety-eight normotensive patients who had HRE were included and were divided into two groups after masked HT had been diagnosed by ambulatory blood pressure monitoring. Conventional echocardiographic parameters and two-dimensional speckle-tracking echocardiography-based LA strain parameters were compared...
November 11, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27815409/a-new-beating-heart-mitral-and-aortic-valve-assessment-model-with-implications-for-valve-intervention-training
#15
Wobbe Bouma, Jayant S Jainandunsing, Arash Khamooshian, Pim van der Harst, Massimo A Mariani, Ehsan Natour
OBJECTIVES: A thorough understanding of mitral and aortic valve motion dynamics is essential in mastering the skills necessary for performing successful valve intervention (open or transcatheter repair or replacement). We describe a reproducible and versatile beating-heart mitral and aortic valve assessment and valve intervention training model in human cadavers. METHODS: The model is constructed by bilateral ligation of the pulmonary veins, ligation of the supra-aortic arteries, creating a shunt between the descending thoracic aorta and the left atrial appendage with a vascular prosthesis, anastomizing a vascular prosthesis to the apex and positioning an intra-aortic balloon pump (IABP) in the vascular prosthesis, cross-clamping the descending thoracic aorta, and finally placing a fluid line in the shunt prosthesis...
November 3, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27809950/effects-of-prenatal-bisphenol-a-exposure-and-postnatal-overfeeding-on-cardiovascular-function-in-female-sheep
#16
S M J MohanKumar, T D Rajendran, A K Vyas, V Hoang, N Asirvatham-Jeyaraj, A Veiga-Lopez, N B Olivier, V Padmanabhan, P S MohanKumar
Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on the cardiovascular system. Pregnant sheep were given daily subcutaneous injections of corn oil (control) or BPA (0.5 mg/kg/day in corn oil) from day 30 to day 90 of gestation. A subset of female offspring of these dams were overfed to increase body weight to ~30% over that of normal fed controls...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27805509/decompression-of-left-ventricle-during-venoarterial-extracorporeal-membrane-oxygenation-support-as-a-step-to-transplant
#17
Bahadır Gültekin, Özgür Ersoy, İlknur Akkaya, Çağrı Kayıpmaz, Araş Pirat, Atilla Sezgin
OBJECTIVES: Left ventricular distention can be recognized during the use of venoarterial extracorporeal membrane oxygenation as a key complication. Left ventricular decompression may decrease pulmonary pressure, minimize ventricular distention, and allow myocardial recovery. MATERIALS AND METHODS: We applied venoarterial extracorporeal membrane oxygenation to 4 patients while on a wait list for cardiac transplant. RESULTS: Two patients with severe heart failure developed high end-diastolic pressures leading to left ventricular distention...
2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27801691/sudden-cardiac-death-in-transposition-of-the-great-arteries-with-a-mustard-or-senning-baffle-the-myocardial-ischemia-hypothesis
#18
Paul Khairy
PURPOSE OF REVIEW: The literature on sudden death in transposition of the great arteries (D-TGA) with atrial switch surgery is reviewed and a pathophysiological mechanism is proposed. RECENT FINDINGS: Over 80% of sudden deaths in patients with D-TGA and Mustard or Senning baffles occur during exercise. Factors most consistently associated with ventricular arrhythmias and sudden death include heart failure parameters and atrial arrhythmias. Atrial arrhythmias have been observed to trigger malignant ventricular arrhythmias...
January 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27776714/assessment-for-pulmonary-artery-hypertension-using-clinical-and-echocardiographic-criteria-in-patients-with-systemic-sclerosis
#19
Nadera Methia, Samia Latreche, Omar Ait Mokhtar, Jean-Jacques Monsuez, Salim Benkhedda
BACKGROUND: Prognosis of systemic sclerosis (SSc) is affected by pulmonary artery hypertension (PAH). METHODS: Among 202 patients (mean age: 46.1 ± 13.3 years; 177 women) with SSc, those with a tricuspid regurgitation (TR) jet maximal velocity at 2D-echocardiography (2DE) < 2.8m/second were not considered at high risk for PAH, whereas those with a TR velocity >3m/second or between 2.8 and 3m/second and associated with dyspnea were. RESULTS: Among 22 patients at risk, 15 (mean age: 50...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27768204/in-vitro-performance-investigation-of-syncardia%C3%A2-freedom%C3%A2-driver-via-patient-simulator-mock-loop
#20
Riccardo Toninato, Silvia Scuri, Vincenzo Tarzia, Gino Gerosa, Francesca M Susin
PURPOSE: The gold standard therapy for patients with advanced heart failure is heart transplant. The gap between donors and patients in waiting lists promoted the development of circulatory support devices, such as the total artificial heart (TAH). Focusing on in vitro tests performed with CardioWest™ TAH (CW) driven by the SynCardia Freedom® portable driver (FD) the present study goals are: i) prove the reliability of a hydraulic circuit used as patient simulator to replicate a quasi-physiological scenario for various hydrodynamic conditions, ii) investigate the hydrodynamic performance of the CW FD, iii) help clinicians in possible interpretation of clinical cases outcomes...
November 29, 2016: International Journal of Artificial Organs
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