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https://www.readbyqxmd.com/read/28638961/evaluation-of-systolic-and-diastolic-properties-of-hypertensive-heart-failure-using-speckle-tracking-echocardiography-with-high-volume-rates
#1
Shingo Minatoguchi, Masanori Kawasaki, Ryuhei Tanaka, Takashi Yoshizane, Koji Ono, Maki Saeki, Maki Nagaya, Hidemaro Sato, Kazuhiko Nishigaki, Toshiyuki Noda, Michael R Zile, Shinya Minatoguchi
Left ventricular (LV) properties in hypertension (HTN) could be deteriorated by pressure overload, especially in endocardium, resulting in hypertensive heart failure (HHF). We sought to noninvasively examine LV systolic and diastolic functions at three myocardial layers in HTN and elucidate features of HHF by speckle-tracking echocardiography (STE) with high volume rates. We examined normotensive controls (n = 54), HTN patients without LV hypertrophy (LVH) (n = 50), and HTN patients with LVH (n = 40) and HHF patients (n = 45)...
June 21, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28638785/hydrophilic-sponges-for-leaf-inspired-continuous-pumping-of-liquids
#2
Tingjiao Zhou, Jinbin Yang, Deyong Zhu, Jieyao Zheng, Stephan Handschuh-Wang, Xiaohu Zhou, Junmin Zhang, Yizhen Liu, Zhou Liu, Chuanxin He, Xuechang Zhou
A bio-inspired, leaf-like pumping strategy by mimicking the transpiration process through leaves is developed for autonomous and continuous liquid transport enabled by durable hydrophilic sponges. Without any external power sources, flows are continuously generated ascribed to the combination of capillary wicking and evaporation of water. To validate this method, durable hydrophilic polydimethylsiloxane sponges modified with polyvinyl alcohol via a "dip-coat-dry" method have been fabricated, which maintains hydrophilicity more than 2 months...
June 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28637722/cross-sectional-surveillance-study-to-phenotype-lorry-drivers-sedentary-behaviours-physical-activity-and-cardio-metabolic-health
#3
Veronica Varela-Mato, Orlagh O'Shea, James A King, Thomas Yates, David J Stensel, Stuart Jh Biddle, Myra A Nimmo, Stacy A Clemes
OBJECTIVES: Elevated risk factors for a number of chronic diseases have been identified in lorry drivers. Unhealthy lifestyle behaviours such as a lack of physical activity (PA) and high levels of sedentary behaviour (sitting) likely contribute to this elevated risk. This study behaviourally phenotyped UK lorry drivers' sedentary and non-sedentary behaviours during workdays and non-workdays and examined markers of drivers cardio-metabolic health. SETTING: A transport company from the East Midlands, UK...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28637706/endothelial-mineralocorticoid-receptor-contributes-to-systolic-dysfunction-induced-by-pressure-overload-without-modulating-cardiac-hypertrophy-or-inflammation
#4
Ane M Salvador, M Elizabeth Moss, Mark Aronovitz, Kathleen B Mueller, Robert M Blanton, Iris Z Jaffe, Pilar Alcaide
Heart Failure (HF) is associated with increased circulating levels of aldosterone and systemic inflammation. Mineralocorticoid receptor (MR) antagonists block aldosterone action and decrease mortality in patients with congestive HF However, the molecular mechanisms underlying the therapeutic benefits of MR antagonists remain unclear. MR is expressed in all cell types in the heart, including the endothelial cells (EC), in which aldosterone induces the expression of intercellular adhesion molecule 1 (ICAM-1)...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28627046/donor-specific-antibodies-are-associated-with-micro-and-macrovascular-coronary-disease-restrictive-myocardial-damage-and-poor-outcome-in-heart-transplanted-patients
#5
Tor Skibsted Clemmensen, Pernille Koefoed-Nielsen, Lis-Ann Jensen, Steen Hvitfeldt Poulsen, Niels Ramsing Holm, Brian Bridal Løgstrup, Evald Høj Christiansen, Jouke Dijkstra, Kamilla Pernille Bjerre Valen, Hans Eiskjaer
AIMS: We examined the relationship between donor-specific HLA antibody (DSA) presence and graft function, hemodynamics, cardiac allograft vasculopathy (CAV), and major adverse cardiac events (MACE) in stable long-term heart-transplanted (HTx) patients. METHODS: Sera from 79 patients (median 7.5 years after HTx) were analyzed for DSA presence. Graft function was evaluated by echocardiography and right heart catheterization. CAV-burden was determined by coronary angiography, optical coherence tomography (OCT), and coronary flow velocity reserve (CFVR)...
June 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28626160/effect-of-anemia-on-cardiovascular-hemodynamics-therapeutic-strategy-and-clinical-outcomes-in-patients-with-heart-failure-and-hemodynamic-congestion
#6
Muneyoshi Tanimura, Kaoru Dohi, Naoki Fujimoto, Keishi Moriwaki, Taku Omori, Yuichi Sato, Emiyo Sugiura, Naoto Kumagai, Shiro Nakamori, Tairo Kurita, Eitaro Fujii, Norikazu Yamada, Masaaki Ito
BACKGROUND: We investigated the effect of anemia on cardiovascular hemodynamics, therapeutic strategies and clinical outcomes in heart failure (HF) patients.Methods and Results:We divided 198 consecutive HF patients who underwent right heart catheterization before in-hospital HF treatment into 2 groups according to the presence or absence of hemodynamic congestion (HC: mean pulmonary capillary wedge pressure ≥15 mmHg and/or mean right atrial pressure ≥10 mmHg). The hemoglobin level correlated with the cardiac index (CI) and systemic vascular resistance index (SVRI) (r=-0...
June 17, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28625438/efficacy-of-prophylactic-doses-of-intravenous-nitroglycerin-in-preventing-myocardial-ischemia-under-general-anesthesia-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis
#7
REVIEW
Hiroshi Hoshijima, Yohei Denawa, Takahiro Mihara, Risa Takeuchi, Norifumi Kuratani, Tsutomu Mieda, Yoshinori Iwase, Toshiya Shiga, Zen'ichiro Wajima, Hiroshi Nagasaka
STUDY OBJECTIVE: To evaluate the efficacy of intravenous nitroglycerin (TNG) in preventing intraoperative myocardial ischemia (MI) under general anesthesia. Moreover, we analyzed the hemodynamic changes in heart rate (HR), mean blood pressure (MBP), and pulmonary capillary wedge pressure (PCWP) associated with TNG administration both before and after the induction of anesthesia. DESIGN: Meta-analysis. SETTING: Operating room, cardiac surgery or non-cardiac surgery, all surgeries were elective measurements...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28625241/-efficacy-and-safety-of-intravenous-recombinant-human-brain-natriuretic-peptide-in-patients-with-severe-heart-failure-a-prospective-multicenter-clinical-study
#8
Xue Feng, Yue Wu, Ying Meng, Yizhen Wei
OBJECTIVE: To explore the efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) in the patients with severe heart failure (HF). METHODS: A prospective multicenter study was conducted. Patients whose age > 18 years old, and with the New York Heart Association (NYHA) cardiac function grade over III-IV, acute cardiac insufficiency and the acute exacerbation of chronic cardiac insufficiency admitted to intensive care unit/cardiovascular care unit (ICU/CCU) of 58 Hospitals in China were enrolled...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625165/transpulmonary-thermodilution-advantages-and-limits
#9
REVIEW
Xavier Monnet, Jean-Louis Teboul
BACKGROUND: For complex patients in the intensive care unit or in the operating room, many questions regarding their haemodynamic management cannot be answered with simple clinical examination. In particular, arterial pressure allows only a rough estimation of cardiac output. Transpulmonary thermodilution is a technique that provides a full haemodynamic assessment through cardiac output and other indices. MAIN BODY: Through the analysis of the thermodilution curve recorded at the tip of an arterial catheter after the injection of a cold bolus in the venous circulation, transpulmonary thermodilution intermittently measures cardiac output...
June 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28619665/computer-modelling-of-electro-osmotically-augmented-three-layered-microvascular-peristaltic-blood-flow
#10
Dharmendra Tripathi, Abhilesh Borode, Ravinder Jhorar, O Anwar Bég, Abhishek Kumar Tiwari
A theoretical study is presented here for the electro-osmosis modulated peristaltic three-layered capillary flow of viscous fluids with different viscosities in the layers. The layers considered here are the core layer, the intermediate layer and the peripheral layer. The analysis has been carried out under a number of physical restrictions viz. Debye-Hückel linearization (i.e. wall zeta potential ≤25mV) is assumed sufficiently small, thin electric double layer limit (i.e. the peripheral layer is much thicker than the electric double layer thickness), low Reynolds number and large wavelength approximations...
June 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28618635/enhanced-drainage-and-thinning-of-liquid-films-between-bubbles-and-solids-that-support-surface-waves
#11
Amihai Horesh, Matvey Morozov, Ofer Manor
We study the thinning and drainage of the intermediate liquid film between a bubble and a solid surface at close proximity in the presence of a surface acoustic wave (SAW) in the solid. Specifically, we employ the diffraction of light to observe a long air bubble confined in a solid rectangular channel filled with silicone oil. This setup, constituting a two-dimensional physical model of thin film drainage, allows us to analyze the influence of a SAW on the rate of thinning of the micron-thick liquid film separating the bubble and the solid substrate...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28615900/predictors-of-outcome-in-children-with-status-epilepticus-during-resuscitation-in-pediatric-emergency-department-a-retrospective-observational-study
#12
Indumathy Santhanam, Sangeetha Yoganathan, V Akila Sivakumar, Rubini Ramakrishnamurugan, Sharada Sathish, Murali Thandavarayan
OBJECTIVES: To study the clinical profile and predictors of outcome in children with status epilepticus (SE) during resuscitation in pediatric emergency department. MATERIALS AND METHODS: This retrospective study was carried out in a tertiary care teaching hospital. Admission and resuscitation data of children, aged between 1 month and 12 years, treated for SE, between September 2013 and August 2014, were extracted using a standard data collection form. Our SE management protocol had employed a modified pediatric assessment triangle to recognize and treat acute respiratory failure, cardiovascular dysfunction (CD), and subtle SE until all parameters resolved...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28615653/electrophoresis-assisted-time-of-flow-mass-spectrometry-using-hollow-nanomechanical-resonators
#13
Swathi Chaudhari, Kamalesh Chaudhari, Seokbeom Kim, Faheem Khan, Jungchul Lee, Thomas Thundat
This report discusses the first demonstration of electrophoresis assisted time-of-flow mass spectrometry using 'U' shaped hollow nanomechanical resonators (HNR). Capillary electrophoresis was coupled with the HNR based mass detection to overcome low ionic conductivity of channels embedded in the HNR preventing direct in-situ electrophoretic separation. The flow of analytes through the HNR was achieved by balancing the hydrodynamic pressure to override the electromotive force and inhibit the motion of analytes towards the anode for capillary electrophoresis...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613962/significant-association-between-renal-function-and-area-of-amyloid-deposition-in-kidney-biopsy-specimens-in-both-aa-amyloidosis-associated-with-rheumatoid-arthritis-and-al-amyloidosis
#14
Takeshi Kuroda, Naohito Tanabe, Eriko Hasegawa, Ayako Wakamatsu, Yukiko Nozawa, Hiroe Sato, Takeshi Nakatsue, Yoko Wada, Yumi Ito, Naofumi Imai, Mitsuhiro Ueno, Masaaki Nakano, Ichiei Narita
The kidney is a major target organ for systemic amyloidosis, which results in proteinuria and an elevated serum creatinine level. The clinical manifestations and precursor proteins of amyloid A (AA) and light-chain (AL) amyloidosis are different, and the renal damage due to amyloid deposition also seems to differ. The purpose of this study was to clarify haw the difference in clinical features between AA and AL amyloidosis are explained by the difference in the amount and distribution of amyloid deposition in the renal tissues...
June 14, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28613315/bulk-advection-and-interfacial-flows-in-the-binary-coalescence-of-surfactant-laden-and-surfactant-free-drops
#15
Emilia Nowak, Zhihua Xie, Nina M Kovalchuk, Omar K Matar, Mark J H Simmons
This work focuses on the study of bulk flows accompanying the coalescence of two aqueous drops, one containing surfactant and the other surfactant-free, in silicone oils of various viscosities. It is observed that the surfactant-free drop intrudes into the surfactant-laden drop in the form of a penetrating jet whose speed increases and average radius decreases with increasing outer phase viscosity. Mixing patterns within the coalescing drops are due to the force imbalance caused by capillary pressure difference and surfactant-induced Marangoni stresses...
June 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28610738/blood-pressure-and-blood-sugar-assessment-by-recent-dental-school-graduates
#16
Michael N Hatton, Heather Orom, Patrick L Anders
OBJECTIVE: Recent dental school graduates' willingness to assess blood pressure and blood sugar in practice is positively influenced by having a workplace policy fostering these assessments. Negative influences toward these assessments include practice culture issues and time management concerns. The aim of this study was to determine whether 2010-2014 graduates of the School of Dental Medicine at Buffalo, NY (UB-SDM) continue to assess blood pressure and capillary blood sugar after graduation...
July 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28605420/prognostic-value-of-mean-pulmonary-artery-pressure-in-the-stable-phase-after-heart-transplantation
#17
Jan-Philip Molkentin, Matthias P Nägele, Michelle Frank, Isabella Sudano, Frank Enseleit, Markus J Wilhelm, Thomas F Lüscher, Francesco Maisano, Frank Ruschitzka, Andreas J Flammer
OBJECTIVES: In heart transplant recipients, elevated mean pulmonary artery pressure (mPAP) shortly before or after transplantation represents a powerful predictor for an adverse short-term outcome. Less is known on cardiac and pulmonary pressures measured in the stable phase after heart transplantation. The aim of this study was to assess the predictive value of mPAP, mean pulmonary capillary wedge pressure and mean central venous pressure in the stable phase after transplantation. METHODS: All patients ( n  = 260, mean age 47...
June 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28604571/hvad-waveform-analysis-as-a-noninvasive-marker-of-pulmonary-capillary-wedge-pressure-a-first-step-toward-the-development-of-a-smart-left-ventricular-assist-device-pump
#18
Jonathan Grinstein, Daniel Rodgers, Sara Kalantari, Gabriel Sayer, Gene H Kim, Nitasha Sarswat, Sirtaz Adatya, Takeyoshi Ota, Valluvan Jeevanandam, Daniel Burkhoff, Nir Uriel
Flow waveforms are an important feature of the HVAD left ventricular assist device (LVAD) that provides information about HVAD function and patient hemodynamics. We assessed the properties of one specific aspect of the waveform, the slope of the ventricular filling phase (VFP), and its correlation with pulmonary capillary wedge pressure (PCWP). A total of 101 screenshots from the HVAD monitor and simultaneous hemodynamic measurements were obtained simultaneously during sequential stages of invasive hemodynamic ramp studies...
June 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28602085/implementation-of-online-preconcentration-and-microsecond-time-resolution-to-capillary-electrophoresis-single-particle-inductively-coupled-plasma-mass-spectrometry-ce-sp-icp-ms-and-its-application-in-silver-nanoparticle-analysis
#19
Darya Mozhayeva, Ingo Strenge, Carsten Engelhard
Capillary electrophoresis (CE) coupled to single particle inductively coupled plasma mass-spectrometry (SP-ICP-MS) was used for the first time with a prototype data acquisition (μsDAQ) system that features 5 μs time resolution (100% duty cycle) to separate and quantify mixtures of silver nanoparticles (Ag NPs). Additionally, an online preconcentration technique, reversed electrode polarity stacking mode (REPSM), was applied for Ag NPs analysis with CE-SP-ICP-MS for the first time. After optimization, best results were achieved using a injection time of 110 s and a constant pressure of 50 mbar in hydrodynamic injection mode...
June 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28599863/recent-advances-in-capillary-ultrahigh-pressure-liquid-chromatography
#20
REVIEW
Laura E Blue, Edward G Franklin, Justin M Godinho, James P Grinias, Kaitlin M Grinias, Daniel B Lunn, Stephanie M Moore
In the twenty years since its initial demonstration, capillary ultrahigh pressure liquid chromatography (UHPLC) has proven to be one of most powerful separation techniques for the analysis of complex mixtures. This review focuses on the most recent advances made since 2010 towards increasing the performance of such separations. Improvements in capillary column preparation techniques that have led to columns with unprecedented performance are described. New stationary phases and phase supports that have been reported over the past decade are detailed, with a focus on their use in capillary formats...
May 17, 2017: Journal of Chromatography. A
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