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https://www.readbyqxmd.com/read/29771701/dynamic-contrast-enhanced-ultrasound-identifies-microcirculatory-alterations-in-sepsis-induced-acute-kidney-injury
#1
Alexandre Lima, Tom van Rooij, Bulent Ergin, Michele Sorelli, Yasin Ince, Patricia A C Specht, Egbert G Mik, Leonardo Bocchi, Klazina Kooiman, Nico de Jong, Can Ince
OBJECTIVES: We developed quantitative methods to analyze microbubble kinetics based on renal contrast-enhanced ultrasound imaging combined with measurements of sublingual microcirculation on a fixed area to quantify early microvascular alterations in sepsis-induced acute kidney injury. DESIGN: Prospective controlled animal experiment study. SETTING: Hospital-affiliated animal research institution. SUBJECTS: Fifteen female pigs...
May 15, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29763373/oral-glucose-challenge-impairs-skeletal-muscle-microvascular-blood-flow-in-healthy-people
#2
Ryan D Russell, Donghua Hu, Timothy Greenaway, James E Sharman, Stephen Rattigan, Stephen M Richards, Michelle A Keske
Skeletal muscle microvascular (capillary) blood flow increases in the post-prandial state or during insulin infusion due to dilation of pre-capillary arterioles to augment glucose disposal. This effect occurs independent of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict pre-capillary arterioles, and causes muscle insulin resistance in vivo. We hypothesize that acute hyperglycemia impairs post-prandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29757656/multilevel-morphology-of-complex-nanoporous-materials
#3
Ahmad Motahari, Naiping Hu, Amir Vahid, Abdollah Omrani, Abbas Ali Rostami, Dale W Schaefer
This work exploits gas adsorption and small-angle X-ray scattering (SAXS) to illuminate morphology of complex nanoporous materials. We resolve multiple classes of porosity including previously undetected large-scale texture that significantly compromises the canonical interpretation of gas adsorption. Specifically, a UVM-7 class mesoporous silica was synthesized that has morphological features on three length scales: macropores due to packing of 150-nm globules, 1.9-nm-radius spherical mesopores inside the globules and >7-nm pockets on and between the globules...
May 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29755961/correlation-and-interchangeability-of-venous-and-capillary-blood-gases-in-non-critically-ill-neonates
#4
Ratna N G B Tan, Steffen C Pauws, Evelyne van Loon, Vivanne E H J Smits, Enrico Lopriore, Arjan B Te Pas
Background: Venous blood gas (VBG) is frequently used in the neonatal unit as alternative for capillary blood gas (CBG). However, studies reporting correlation are conflicting and data on interchangeability in neonates are lacking. Objective: We investigated the correlation and interchangeability of the components between VBG and CBG in infants admitted to the neonatal intensive care unit. Methods: In a prospective study in the neonatal unit in Leiden University Medical Center (Netherlands), simultaneously VBG and CBG were withdrawn in neonates when both venous puncture and intravenous access as blood gas monitoring was indicated...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29755623/main-considerations-of-cardiogenic-shock-and-its-predictors-systematic-review
#5
REVIEW
Maria Christiane Valeria Braga Braile-Sternieri, Eliana Migliorini Mustafa, Victor Rodrigues Ribeiro Ferreira, Sofia Braile Sabino, Giovanni Braile Sternieri, Lucia Angelica Buffulin de Faria, Bethina Canaroli Sbardellini, Cibele Olegario Vianna Queiroz, Domingo Marcolino Braile, Idiberto Jose Zotarelli Filho
The mortality rate of post-infarction cardiogenic shock (CS) was 80.0-90.0%. Recent studies show a significant reduction of hospital mortality to approximately 50.0%. CS is defined as systemic tissue hypoperfusion resulting from systolic and/or diastolic heart dysfunction, the main cause of which is acute myocardial infarction (AMI). The main predictors are biological markers such as troponin, CKMB and lactate. A systematic literature review and meta-analysis is performed in order to present and correlate the main literary findings on CS and its evolution with possible changes in biomarkers such as troponin, lactate and CKMB...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29754663/the-prognostic-value-of-the-relationship-between-right-atrial-and-pulmonary-capillary-wedge-pressure-in-diverse-cardiovascular-conditions
#6
Douglas Marshall Brinkley, Kalon K L Ho, Mark H Drazner, Robb D Kociol
BACKGROUND: Physical examination of jugular venous pressure is used to estimate right atrial (RA) pressure and infer left-sided filling pressure to assist volume management. Previous studies in advanced heart failure patients showed about 75% concordance between RA and pulmonary capillary wedge (PCW) pressures. We sought to determine the relationship between mean RA and mean PCW pressure and assess the clinical significance in a broad population of patients undergoing invasive right heart catheterization (RHC)...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29750713/valsalva-maneuver-and-peripapillary-oct-angiography-vessel-density
#7
Gábor Holló
PURPOSE: To investigate the potential influence of breath holding on the results of peripapillary vessel density (VD) measurement with optical coherence tomography angiography (OCTA). METHODS: Three peripapillary VD measurements were made at 2-minute intervals on the right eye of 12 healthy young volunteers using the Angiovue/RTvue-XR OCT (software version 2017.1, Phase 7 update) without changing the head and body positions. During the first 2 measurements the volunteers were breathing normally...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29745477/outcomes-of-patients-with-cardiogenic-shock-treated-with-tandemheart-%C3%A2-percutaneous-ventricular-assist-device-importance-of-support-indication-and-definitive-therapies-as-determinants-of-prognosis
#8
LaVone Smith, Anthony Peters, Sula Mazimba, Michael Ragosta, Angela M Taylor
OBJECTIVES: The objective of this study was to review the characteristics of patients in cardiogenic shock treated with TandemHeart® percutaneous ventricular assist device (pVAD) to determine influential predictors of survival. BACKGROUND: The TandemHeart® pVAD is used in the management of patients with cardiogenic shock resulting from a variety of conditions. Several studies have documented the efficacy of this therapy and outlined its complications. Still, there is little data to guide the effective and appropriate use of this resource...
May 10, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29743074/genetic-analyses-in-a-cohort-of-191-pulmonary-arterial-hypertension-patients
#9
Hang Yang, Qixian Zeng, Yanyun Ma, Bingyang Liu, Qianlong Chen, Wenke Li, Changming Xiong, Zhou Zhou
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder associated with high pulmonary artery pressure. Genetic testing enables early diagnosis and offers an opportunity for family screening. To identify genetic mutations and help make a precise diagnosis, we performed genetic testing in 191 probands with PAH and tried to analyze the genotype-phenotype correlation. METHODS: Initially, PAH samples (n = 119) were submitted to BMPR2 screening using Sanger sequencing...
May 9, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29742453/effect-of-p-tyrosol-on-hemorheological-parameters-and-cerebral-capillary-network-in-young-spontaneously-hypertensive-rats
#10
Mark B Plotnikov, Oleg I Aliev, Anastasia V Sidekhmenova, Alexander Y Shamanaev, Anna M Anishchenko, Tatiana I Fomina, Tatiana M Plotnikova, Alexander M Arkhipov
BACKGROUND: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms. OBJECTIVE: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied. METHODS: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i...
May 6, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29733761/determination-of-low-solvent-concentration-by-nano-porous-silicon-photonic-sensors-using-volatile-organic-compound-method
#11
Huy Bui, Van Hoi Pham, Van Dai Pham, Thi Hong Cam Hoang, Thanh Binh Pham, Thuy Chi Do, Quang Minh Ngo, Thuy Van Nguyen
A vast majority of the organic solvents used in industry and laboratories are volatile, hazardous and toxic organic compounds, they are considered as a potent problem for human health and a cause of environmental pollution. Although analytical laboratory methods can determine extremely low solvent concentration, the sensing method with low cost and high sensitivity remains a conundrum. This paper presents and compares three methods (volatile organic compound (VOC), liquid drop and saturated vapour pressure) for determination of organic solvents in liquid environment by using photonic sensor based on nano-porous silicon (pSi) microcavity structures...
May 7, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29732498/multiobjective-optimization-of-liquid-chromatography-triple-quadrupole-mass-spectrometry-analysis-of-underivatized-human-urinary-amino-acids-through-chemometrics
#12
Manuel David Peris-Díaz, Miguel A Sentandreu, Enrique Sentandreu
Optimization of instrumental settings of a triple-quadrupole mass analyzer was performed by Box-Behnken design, support vector machines, and a Pareto-optimality approach. This time-saving, stepped chemometric strategy was used to model the signal response of underivatized human urinary amino acids. Drying gas flow, nebulizer pressure, sheath gas flow, and capillary voltage settings were exhaustively studied beyond the parameters conventionally optimized in triple-quadrupole devices (multiple reaction monitoring transitions, fragmentor and collision energy voltages)...
May 7, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29732150/efficacy-of-prophylactic-epidural-ketamine-for-reducing-shivering-in-patients-undergoing-caesarean-section-with-combined-spinal-epidural-anesthesia
#13
Xing Xue, Ying Lv, Youhong Zhao, Yufang Leng, Yan Zhang
Intravenous ketamine is known to inhibit postoperative shivering; however, at present, there has been little research on whether this effect may be achieved with epidural application. The aim of the present study was to evaluate the efficacy and safety of epidural ketamine as a prophylactic agent to prevent shivering in patients undergoing caesarean section during combined spinal-epidural anesthesia. A prospective, randomized, double-blind study was performed. A total of 60 patients who were undergoing elective caesarean section under combined spinal-epidural anesthesia and had an American Society of Anesthesiologists physical status of I or II were recruited...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29724647/preparation-characterization-and-application-of-polymethacrylate-based-monolithic-columns-for-fast-and-efficient-separation-of-alkanes-alcohols-alkylbenzenes-and-isomeric-mixtures-by-gas-chromatography
#14
Munir S Obbed, Ahmad Aqel, Z A Al Othman, A-Yacine Badjah-Hadj-Ahmed
Application of monolithic columns in gas chromatography is still considered very limited. In this work, several polymethacrylate-based monolithic capillary columns were fabricated, characterized and used in gas chromatography. The five monomers used were: methyl methacrylate, (MMA), hexyl methacrylate (HMA), glycidyl methacrylate (GMA), 2-butoxyethyl methacrylate (BEMA) and isobornyl methacrylate (IBMA), while ethylene dimethacrylate was the crosslinker. The monoliths were synthesized in 30 cm length capillaries possessing inner diameters (i...
April 23, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29718770/endothelial-nitric-oxide-synthase-genotype-is-associated-with-pulmonary-hypertension-severity-in-left-heart-failure-patients
#15
Julio D Duarte, Mayank Kansal, Ankit A Desai, Katherine Riden, Meghan J Arwood, Alex A Yacob, Thomas D Stamos, Larisa H Cavallari, Roham T Zamanian, Sanjiv J Shah, Roberto F Machado
The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role of NOS in HF-PH. DNA samples from 118 patients with HF-PH were genotyped for the NOS3 rs1799983 and NOS2 rs3730017 polymorphisms. A multiple regression model was used to compare hemodynamic measurements between genotype groups...
April 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29716488/a-two-centre-observational-study-of-simultaneous-pulse-oximetry-and-arterial-oxygen-saturation-recordings-in-intensive-care-unit-patients
#16
S J Ebmeier, M Barker, M Bacon, R C Beasley, R Bellomo, C Knee Chong, G M Eastwood, J Gilchrist, H Kagaya, J Pilcher, S K Reddy, E Ridgeon, N Sarma, S Spragas, A Tanaka, M Tweedie, M Weatherall, P J Young
The influence of variables that might affect the accuracy of pulse oximetry (SpO<sub>2</sub>) recordings in critically ill patients is not well established. We sought to describe the relationship between paired SpO<sub>2</sub>/SaO<sub>2</sub> (oxygen saturation via arterial blood gas analysis) in adult intensive care unit (ICU) patients and to describe the diagnostic performance of SpO<sub>2</sub> in detecting low SaO<sub>2</sub> and PaO<sub>2</sub>...
May 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29713107/lymphatic-system-flows
#17
James E Moore, Christopher D Bertram
The supply of oxygen and nutrients to tissues is performed by the blood system, and involves a net leakage of fluid outward at the capillary level. One of the principal functions of the lymphatic system is to gather this fluid and return it to the blood system to maintain overall fluid balance. Fluid in the interstitial spaces is often at subatmospheric pressure, and the return points into the venous system are at pressures of approximately 20 cmH2 O. This adverse pressure difference is overcome by the active pumping of collecting lymphatic vessels, which feature closely spaced one-way valves and contractile muscle cells in their walls...
January 2018: Annual Review of Fluid Mechanics
https://www.readbyqxmd.com/read/29710689/pulmonary-hemodynamic-effects-and-pulmonary-arterial-compliance-during-hypovolemic-shock-and-reinfusion-with-human-relaxin-2-serelaxin-treatment-in-a-sheep-model
#18
René Schiffner, Thomas Lehmann, Sabine J Bischoff, Timo Zippelius, Marius Nistor, Martin Schmidt
BACKGROUND: Previous studies on the recombinant form of human relaxin-2 (serelaxin) have shown a decrease of pulmonary hemodynamics after serelaxin injection. Currently, the effect of serelaxin treatment during hypovolemia in a large animal model remains mostly unknown. METHODS: 12 sheep were randomly assigned to a sham or serelaxin (30μg/kg serelaxin) group and underwent right heart catheterization. 50% of the estimated total blood volume were removed to induce hypovolemia, and subsequently retransfused 20 min later (reinfusion)...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29706077/non-wettable-hierarchical-structure-effect-on-droplet-impact-and-spreading-dynamics
#19
Hyungmo Kim, SeolHa Kim
In this study, the nano/micro hierarchical structure effect of a non-wettable surface on droplet impact was investigated by high-speed visualization. A dual-scale structure of a superhydrophobic surface was designed for manipulating a wide range of capillary pressures (103-106 Pa), and it was supposed to trigger a hierarchical effect on the droplet dynamics. Distilled water droplet of various size and initial velocity were subjected to the prepared samples, and the impact behavior, the spreading diameter and contacted time, were quantitatively measured...
April 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29704029/ion-concentration-in-micro-and-nanoscale-electrospray-emitters
#20
Elizabeth M Yuill, Lane A Baker
Solution-phase ion transport during electrospray has been characterized for nanopipettes, or glass capillaries pulled to nanoscale tip dimensions, and micron-sized electrospray ionization emitters. Direct visualization of charged fluorophores during the electrospray process is used to evaluate impacts of emitter size, ionic strength, analyte size, and pressure-driven flow on heterogeneous ion transport during electrospray. Mass spectrometric measurements of positively- and negatively-charged proteins were taken for micron-sized and nanopipette emitters under low ionic strength conditions to further illustrate a discrepancy in solution-driven transport of charged analytes...
April 28, 2018: Analytical and Bioanalytical Chemistry
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