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https://www.readbyqxmd.com/read/28227459/leg-fluid-accumulation-during-prolonged-sitting
#1
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Azadeh Yadollahi, Jonathan Rubianto, Milos Popovic
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227085/an-object-oriented-model-of-the-cardiopulmonary-system-with-emphasis-on-the-gravity-effect
#2
Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Berno Misgeld
We introduce a novel comprehensive model of the cardiopulmonary system with emphasis on perfusion and ventilation distribution along the vertical thorax axis under the gravity effect. By using an object-oriented environment, the complex physiological system can be represented by a network of electrical, lumped-element compartments. The lungs are divided into three zones: upper, middle, and lower zone. Blood flow increases with the distance from the apex to the base of the lungs. The upper zone is characterized by a complete collapse of the pulmonary capillary vasculature; thus, there is no flow in this zone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223154/idiopathic-and-systemic-sclerosis-associated-pulmonary-arterial-hypertension-a-comparison-of-demographic-haemodynamic-and-magnetic-resonance-imaging-characteristics-and-outcomes
#3
Sheila Ramjug, Nehal Hussain, Judith Hurdman, Catherine Billings, Athanasios Charampopoulos, Charlie A Elliot, David G Kiely, Ian Sabroe, Smitha Rajaram, Andrew J Swift, Robin Condliffe
BACKGROUND: Previous studies have identified survival in systemic sclerosis (SSc)-associated pulmonary arterial hypertension (SSc-PAH) to be worse than in idiopathic pulmonary arterial hypertension (IPAH). We investigated differences between these conditions by comparing demographic, haemodynamic and radiological characteristics and outcomes in a large cohort of incident patients. METHODS: 651 patients diagnosed with IPAH or SSc-associated pre-capillary pulmonary hypertension were included...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28219811/stress-echocardiography-in-patients-who-experienced-mechanical-ventilation-weaning-failure
#4
Manuel Ruiz-Bailén, Jesús Cobo-Molinos, Ana Castillo-Rivera, María Dolores Pola-Gallego-de-Guzmán, Antonio Cárdenas-Cruz, Antonio Martínez-Amat, María Sevilla-Martínez, Clara Hernández-Caballero
INTRODUCTION: Critically ill patients may suffer varying degrees of temporary myocardial dysfunction during respiratory weaning that could play an important role in weaning failure. OBJECTIVES: In this study, we tried to assess the existence of temporary diastolic dysfunction during respiratory weaning. METHODS: Inclusion period is from 2006 to 2015. In this study, we included 181 ventilated patients with cardiogenic shock that were being weaned from mechanical ventilation...
January 18, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28215689/histomorphometry-of-the-placental-vasculature-and-microcotyledons-in-thoroughbred-mares-with-chronic-laminitis
#5
Fernanda M Pazinato, Bruna da Rosa Curcio, Cristina G Fernandes, Carlos A Santos, Lorena S Feijó, Antonio Sérgio Varela, Carlos E W Nogueira
The objective of this study was to assess the placental vasculature and microcotyledons in pregnant mares with chronic laminitis. Twenty-six pregnant mares were enrolled in the study, 13 had chronic laminitis (Laminitis Group) and 13 were healthy mares (Healthy Group). Arterial systolic pressure and heart rate were measured in the last 30 days of gestation. After foaling, the fetal membranes were grossly evaluated and samples were harvested for histopathologic examination. All mares had digitalized images taken from chorioallantois for histomorphometry analyses (software-NIH ImageJ)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28213151/automatic-method-for-estimation-of-in-situ-effective-contact-angle-from-x-ray-micro-tomography-images-of-two-phase-flow-in-porous-media
#6
Alessio Scanziani, Kamaljit Singh, Martin J Blunt, Alberto Guadagnini
Multiphase flow in porous media is strongly influenced by the wettability of the system, which affects the arrangement of the interfaces of different phases residing in the pores. We present a method for estimating the effective contact angle, which quantifies the wettability and controls the local capillary pressure within the complex pore space of natural rock samples, based on the physical constraint of constant curvature of the interface between two fluids. This algorithm is able to extract a large number of measurements from a single rock core, resulting in a characteristic distribution of effective in situ contact angle for the system, that is modelled as a truncated Gaussian probability density distribution...
February 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28211335/a-comparative-study-of-extractant-and-chromatographic-phases-for-the-rapid-and-sensitive-determination-of-six-phthalates-in-rainwater-samples
#7
M Fernández-Amado, M C Prieto-Blanco, P López-Mahía, S Muniategui-Lorenzo, D Prada-Rodríguez
Six phthalic acid esters were determined in rainwater samples, from which a very low sample volume was collected. This method combines on-line in-tube solid-phase microextraction coupled to high-performance liquid chromatography with a diode-array detector. In order to obtain a short analysis time and to reduce the consumption of organic solvents, two chromatographic phases (C18 monolithic and cyanopropyl silica) are compared. Although three critical pairs are found, faster separation, good resolution and lower pressures are achieved using C18 monolithic column...
February 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28210642/high-output-heart-failure-contributing-to-recurrent-epistaxis-kiesselbach-area-syndrome-in-a-patient-with-hereditary-hemorrhagic-telangiectasia
#8
Venugopal Brijmohan Bhattad, Jennifer N Bowman, Hemang B Panchal, Timir K Paul
Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare genetic blood disorder that leads to abnormal bleeding due to absent capillaries and multiple abnormal blood vessels known as arteriovenous malformations. A feature of HHT is high-output heart failure due to multiple arteriovenous malformations. High-output heart failure can lead to recurrent epistaxis Kiesselbach area syndrome (REKAS), further exacerbating heart failure through increased blood loss and resultant anemia...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28208779/proof-of-concept-of-integrated-load-measurement-in-3d-printed-structures
#9
Michaël Hinderdael, Zoé Jardon, Margot Lison, Dieter De Baere, Wim Devesse, Maria Strantza, Patrick Guillaume
Currently, research on structural health monitoring systems is focused on direct integration of the system into a component or structure. The latter results in a so-called smart structure. One example of a smart structure is a component with integrated strain sensing for continuous load monitoring. Additive manufacturing, or 3D printing, now also enables such integration of functions inside components. As a proof-of-concept, the Fused Deposition Modeling (FDM) technique was used to integrate a strain sensing element inside polymer (ABS) tensile test samples...
February 9, 2017: Sensors
https://www.readbyqxmd.com/read/28196095/depth-dependent-flow-and-pressure-characteristics-in-cortical-microvascular-networks
#10
Franca Schmid, Philbert S Tsai, David Kleinfeld, Patrick Jenny, Bruno Weber
A better knowledge of the flow and pressure distribution in realistic microvascular networks is needed for improving our understanding of neurovascular coupling mechanisms and the related measurement techniques. Here, numerical simulations with discrete tracking of red blood cells (RBCs) are performed in three realistic microvascular networks from the mouse cerebral cortex. Our analysis is based on trajectories of individual RBCs and focuses on layer-specific flow phenomena until a cortical depth of 1 mm. The individual RBC trajectories reveal that in the capillary bed RBCs preferentially move in plane...
February 14, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28195509/reduced-subarachnoid-fluid-diffusion-in-enlarged-subarachnoid-spaces-of-infancy
#11
Matthew T Whitehead, Bonmyong Lee, Audrey McCarron, Stanley T Fricke, Gilbert Vezina
Background and purpose Enlargement of the subarachnoid spaces in infancy (ESSI) is a common cause of macrocephaly without proven explanation. We have observed subarachnoid diffusion to be decreased in these patients. We aim to quantify the diffusivity of ventricular and subarachnoid cerebrospinal fluid in ESSI patients, to determine if diffusion characteristics deviate from normocephalic infants, and to propose a unique mechanism for ESSI. Materials and methods 227 consecutive brain magnetic resonance exams from different macrocephalic children were retrospectively reviewed after institutional review board waiver...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28194956/direct-imaging-of-single-plasmonic-metal-nanoparticles-in-capillary-with-laser-light-sheet-scattering-imaging
#12
Xuan Cao, Jingjing Feng, Qi Pan, Bin Xiong, Yan He, Edward S Yeung
Understanding the heterogeneous distribution of the physical and chemical properties of plasmonic metal nanoparticles is fundamentally important to their basic and applied research. Traditionally, they are obtained either indirectly via bulk spectroscopic measurements plus electron microscopic characterizations, or through single molecule/particle imaging of nanoparticles immobilized on planar substrates. In this study, by using light-sheet scattering microscopy with a supercontinuum white laser, highly sensitive imaging of individual MNPs flowing inside a capillary, driven by either pressure or electric field, was achieved for the first time...
February 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28193784/impaired-myogenic-response-of-the-afferent-arteriole-contributes-to-the-increased-susceptibility-to-renal-disease-in-milan-normotensive-rats
#13
Ying Ge, Fan Fan, Sean P Didion, Richard J Roman
Milan normotensive (MNS) rats are more susceptible to the development of renal disease than Milan hypertensive (MHS) rats, but the genes and pathways involved are unknown. This study compared the myogenic response of isolated perfused afferent arterioles (Af-Art) and autoregulation of renal blood flow (RBF) and glomerular capillary pressure (Pgc) in 6-9-week-old MNS and MHS rats. The diameter of the Af-Art of MHS rats decreased significantly from 14.3 ± 0.5 to 11.5 ± 0.6 μm when perfusion pressure was elevated from 60 to 120 mmHg...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28177279/sodium-glucose-co-transporter-2-inhibitors-and-their-nephroprotective-potential%C3%A2
#14
Natalia G Vallianou, Kyriakos Trigkidis, Christos Kazazis
Chronic kidney disease among patients with diabetes is on the rise. The sodium glucose co-transporters 2 inhibitors are a new class of glucose-lowering agents, which act through a novel mechanism by producing a decline in glucose reabsorption in the kidney, thereby increasing glucosuria and decreasing serum glucose levels. Data suggest that they possess nephroprotective properties. It is noteworthy that the efferent glomerular arteriole is 10 - 100 times more sensitive to the vasoconstrictive properties of angiotensin II than the afferent one and this might account for the consequently higher intra-glomerular capillary pressure, which is believed to be the cornerstone of diabetic nephropathy...
February 8, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28175965/effects-of-platelet-rich-plasma-on-tissue-expansion-in-rabbits
#15
Wang Jinming, Liu Caiyue, Wu Baojin, Liu Antang, Zhang Yingfan, Wang Hui, Zhu Lie, Jiang Hua
BACKGROUND: Tissue expansion has been widely applied in clinic practice. However, the expanded skin is always insufficient for clinical use and how to promote tissue expansion is still a challenge. Platelet-rich plasma (PRP) contains multiple tissue growth factors and has been widely utilized in hard- and soft-tissue augmentation. However, its feasibility to promote tissue expansion has not been explored. The purpose of this study was to evaluate the possible effect of PRP in tissue expansion...
February 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28168428/longer-than-average-length-of-stay-in-acute-heart-failure-determinants-and-outcomes
#16
H R Omar, M Guglin
BACKGROUND: Increased length of stay (LOS) during acute heart failure (HF) hospitalization is associated with readmission and mortality. METHODS: The ESCAPE trial data were utilized to identify determinants and post-discharge outcomes of patients with acute systolic HF requiring longer-than-average LOS (≥7 days). The study endpoints were 6‑month all-cause mortality, all-cause rehospitalization, and the composite endpoint of death, cardiac rehospitalization, and cardiac transplant...
February 6, 2017: Herz
https://www.readbyqxmd.com/read/28165248/molecular-modeling-and-adsorption-properties-of-ordered-silica-templated-cmk-mesoporous-carbons
#17
Surendra Kumar Jain, Roland J-M Pellenq, Keith E Gubbins, Xuan Peng
Realistic molecular models of silica-templated CMK-1, CMK-3, and CMK-5 carbon materials have been developed by using carbon rods and carbon pipes that were obtained by adsorbing carbon in a model MCM-41 pore. The interactions between the carbon atoms with the silica matrix were described using the PN-Traz potential, and the interaction between the carbon atoms was calculated by the reactive empirical bond order (REBO) potential. Carbon rods and pipes with different thicknesses were obtained by changing the silica-carbon interaction strength, the temperature, and the chemical potential of carbon vapor adsorption...
February 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28155717/sph-dem-approach-to-numerically-simulate-the-deformation-of-three-dimensional-rbcs-in-non-uniform-capillaries
#18
Hasitha-Nayanajith Polwaththe-Gallage, Suvash C Saha, Emilie Sauret, Robert Flower, Wijitha Senadeera, YuanTong Gu
BACKGROUND: Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shapes. Computational modelling techniques can be used to successfully predict the behaviour of the RBCs in capillaries. In this study, we report the application of a meshfree particle approach to model and predict the motion and deformation of three-dimensional RBCs in capillaries...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28153450/tailored-liquid-chromatography-mass-spectrometry-analysis-improves-the-coverage-of-the-intracellular-metabolome-of-heparg-cells
#19
Matthias Cuykx, Noelia Negreira, Charlie Beirnaert, Nele Van den Eede, Robim Rodrigues, Tamara Vanhaecke, Kris Laukens, Adrian Covaci
Metabolomics protocols are often combined with Liquid Chromatography-Mass Spectrometry (LC-MS) using mostly reversed phase chromatography coupled to accurate mass spectrometry, e.g. quadrupole time-of-flight (QTOF) mass spectrometers to measure as many metabolites as possible. In this study, we optimised the LC-MS separation of cell extracts after fractionation in polar and non-polar fractions. Both phases were analysed separately in a tailored approach in four different runs (two for the non-polar and two for the polar-fraction), each of them specifically adapted to improve the separation of the metabolites present in the extract...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28152535/the-blood-retinal-barrier-in-the-management-of-retinal-disease-euretina-award-lecture
#20
José Cunha-Vaz
Retinal diseases are the main causes of blindness in the Western world. Diabetic retinopathy and age-related macular degeneration continue to increase in prevalence and as main causes of vision loss. Intravitreal anti-VEGF and steroid injections have raised new expectations for their successful treatment. These agents act by stabilizing the blood-retinal barrier (BRB). Our group defined the BRB by identifying for the first time the tight junctions that unite retinal endothelial cells and are the basis for the inner BRB, an observation later confirmed in retinal pigment epithelial cells and in brain vessels...
2017: Ophthalmologica. Journal International D'ophtalmologie
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