keyword
https://read.qxmd.com/read/37868542/statin-associated-autoimmune-myopathy-masquerading-as-recurrent-falls-in-an-older-adult
#21
Malarkodi Suppamutharwyam, Tunku Muzafar Shah
Statins are widely prescribed in clinical practice. Statin-induced myopathy is relatively common, benign, and resolves after statin withdrawal. However, statin-associated autoimmune myopathy is an exceptionally rare and devastating complication that can occur any time after statin initiation. It is characterized by persistent muscle weakness and elevated creatine kinase levels that persist after statin withdrawal. Herein, we present a challenging case of a statin-associated autoimmune myopathy that developed after a decade of atorvastatin use that resulted in debilitating weakness...
September 2023: Curēus
https://read.qxmd.com/read/37866703/prescribing-statin-therapy-in-physically-in-active-individuals-vs-prescribing-physical-activity-in-statin-treated-patients-a-four-scenario-practical-approach
#22
JOURNAL ARTICLE
Blanca Gavilán-Carrera, Alberto Soriano-Maldonado, Juan Diego Mediavilla-García, Carl J Lavie, José Antonio Vargas-Hitos
Statins are among the most commonly prescribed medications worldwide. Statin-associated muscle symptoms (SAMS) represent a frequent statin-related adverse effect associated with statin discontinuation and increased cardiovascular disease (CVD) events. Emerging evidence indicate that the majority of SAMS might not be actually caused by statins, and the nocebo/drucebo effect (i.e. adverse effects caused by negative expectations) might also explain SAMS. Lifestyle advice in including physical activity (PA) is a cornerstone in the management of CVD risk...
October 20, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37818695/exploring-signals-of-myopathy-associated-with-statin-and-contraindicated-comedications-in-the-realworld
#23
JOURNAL ARTICLE
Sewon Park, Ju Won Lee, Dal Ri Nam, Sun-Young Jung
BACKGROUND: Using statins in combination with other drugs was reported to increase the risk of myopathy. However, there was a sparse number of studies on the incidence of adverse events (AEs) associated with the concomitant use of statin and contraindicated drugs in the real world. OBJECTIVES: This study aimed to identify the risk of concomitant use of statins with contraindicated drugs by exploring signals related to statin-drug interactions. METHODS: We performed a disproportionality analysis for drugs and AEs by applying the case/non-case study using the KIDS-KAERS database (KIDS-KD), 2016-2020...
October 11, 2023: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/37809236/a-case-report-of-mcardle-disease-diagnosed-following-statin-induced-myositis
#24
João S Teles, Catarina T Ramos, Beatriz M Almeida, Anabela V Sousa
McArdle disease is a rare condition, characterized by a deficiency of phosphorylase muscle isoform, an enzyme responsible for the breaking down of glycogen, necessary for obtaining energy. Patients typically present with exercise intolerance, myalgias, fatigue, cramps, muscle stiffness, and/or weakness induced by physical activity. The diagnosis is generally established late, with a median delay of about 29 years. We present the case of a female patient with a long history of myalgias, muscle weakness, and exercise intolerance, diagnosed with McArdle disease by the age of 74, after statin-induced myopathy...
September 2023: Curēus
https://read.qxmd.com/read/37772584/a-case-of-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-myopathy-associated-with-advanced-cervical-carcinoma
#25
JOURNAL ARTICLE
Arnaud Saillant, Mathilde Rasclard, Jean-Baptiste Gaume, Odile Souchaud, Matthieu Bainaud
BACKGROUND: Necrotizing autoimmune myopathy is characterized by skeletal muscle weakness and is frequently associated with cancer. Absence of treatment can lead to severe muscular atrophy but initial symptoms may be insidious and delay the diagnosis. Here, we describe the case of a 70-year-old woman who was diagnosed with mnti-3-hydroxy-3-methylglutaryl-coenzyme A reductase myopathy during chemotherapy course for cervical cancer. CASE REPORT: A 70-year-old woman received chemotherapy for an advanced cervical carcinoma...
October 2023: Anticancer Research
https://read.qxmd.com/read/37771688/a-case-of-anti-hmgcr-myopathy-in-a-patient-with-breast-cancer-and-anti-th-to-antibodies
#26
Mohammad Yassine Chérif, Ioannis Raftakis, Marjolaine Weynand, Elena Dragan, Carole Nagant, Sophie Lecomte, Valérie Badot
Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported. Muscular adverse symptoms are various and, rarely, statin exposure may lead to authentic immune-mediated necrotizing myopathy (IMNM), namely anti-HMGCR myopathy. However, cases of IMNM associated with cancer have been described...
September 2023: Oxford Medical Case Reports
https://read.qxmd.com/read/37658350/pharmacogenetic-analysis-of-inter-ethnic-variability-in-the-uptake-transporter-slco1b1-gene-in-colombian-mozambican-and-portuguese-populations
#27
JOURNAL ARTICLE
Mulata Haile Nega, Derbew Fikadu Berhe, Vera Ribeiro
BACKGROUND: Statin-induced myopathy is reported to be associated with the solute carrier organic anion transporter family member 1B1 gene single nucleotide polymorphism, c.521 T > C. There is no epidemiologic data on this gene polymorphism in several countries. Therefore, this study aimed at assessing the genotype and allele frequencies of the gene variant in three countries. METHODS: This study involved healthy individuals from Colombia, Mozambique, and Portugal...
September 1, 2023: BMC Medical Genomics
https://read.qxmd.com/read/37638785/late-onset-facioscapulohumeral-muscular-dystrophy-type-1-in-previously-undiagnosed-families-presenting-clinical-features-in-an-often-misdiagnosed-disorder
#28
JOURNAL ARTICLE
Kevin J Felice, Charles H Whitaker
INTRODUCTION/AIMS: In our experience, patients with late-onset facioscapulohumeral muscular dystrophy type 1 (FSHD1) are frequently misdiagnosed, some for many years. The aim of this report is to document this clinical experience including the presenting symptoms and misdiagnoses and to discuss the challenges in diagnosing patients with late-onset FSHD1. METHODS: We performed a retrospective medical record review and recorded clinical data on patients with a genetically confirmed diagnosis of FSHD1, who began to have symptoms at 50 years of age or older, and either had no family history of FSHD1 or had a history of an undiagnosed weakness in a family member...
August 28, 2023: Muscle & Nerve
https://read.qxmd.com/read/37634874/editorial-statin-induced-myopathy-a-rare-entity
#29
EDITORIAL
Wirth Theo, Guis Sandrine
No abstract text is available yet for this article.
August 25, 2023: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/37625939/statins-and-immune-mediated-necrotizing-myopathy-variability-in-the-risk
#30
JOURNAL ARTICLE
Thierry Trenque, Jed Hadjoudj, Agathe Trenque, Federica Tralongo, Salomé Martin, Brahim Azzouz
INTRODUCTION: Immune-mediated necrotizing myopathy (IMNM) is a form of statin myopathy characterized by the presence of antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti HMGCR). OBJECTIVES: The aim of this study was to investigate the relationship between the different statins and the risk of IMNM. METHODS: A two-time approach was used. First, we performed a descriptive analysis of the French national pharmacovigilance database (FNPV) for the period from 1985 to december2020...
July 30, 2023: Thérapie
https://read.qxmd.com/read/37612317/dysfunctional-endocannabinoid-cb1-receptor-expression-and-signaling-contribute-to-skeletal-muscle-cell-toxicity-induced-by-simvastatin
#31
JOURNAL ARTICLE
Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Mónika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti
Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000 patients. In this study, we explored the role of the endocannabinoid system (ECS) during muscle toxicity induced by simvastatin. In murine C2C12 myoblasts exposed to simvastatin, levels of the endocannabinoids AEA and 2-AG as well the expression of specific miRNAs (in particular miR-152) targeting the endocannabinoid CB1 gene were increased in a time-dependent manner...
August 23, 2023: Cell Death & Disease
https://read.qxmd.com/read/37605694/spontaneous-development-of-immune-mediated-necrotizing-myopathy-imnm-after-chronic-use-of-statins-a-case-report
#32
Michael T Luong, Paul Danahy, Gerald Y Ho
Statin medications, in addition to lifestyle modifications, have been the regimen of choice for addressing dyslipidemia in the general population. Its widespread use has been justified by increasing evidence that hyperlipidemia is a strong risk factor for the development of atherosclerotic disease resulting in myocardial infarction and other cardiovascular events. Unfortunately, this medication is not tolerated by some patients as it causes uncomfortable side effects such as myalgias, arthralgias, and headaches to name a few...
July 2023: Curēus
https://read.qxmd.com/read/37562881/autoimmune-inflammatory-myopathies
#33
REVIEW
Marinos C Dalakas
The autoimmune inflammatory myopathies constitute a heterogeneous group of acquired myopathies that have in common the presence of endomysial inflammation and moderate to severe muscle weakness. Based on currently evolved distinct clinical, histologic, immunopathologic, and autoantibody features, these disorders can be best classified as dermatomyositis, necrotizing autoimmune myositis, antisynthetase syndrome-overlap myositis, and inclusion body myositis. Although polymyositis is no longer considered a distinct subset but rather an extinct entity, it is herein described because its clinicopathologic information has provided over many years fundamental information on T-cell-mediated myocytotoxicity, especially in reference to inclusion body myositis...
2023: Handbook of Clinical Neurology
https://read.qxmd.com/read/37497026/cost-effectiveness-analysis-of-implementing-polygenic-risk-score-in-a-workplace-cardiovascular-disease-prevention-program
#34
JOURNAL ARTICLE
Deo Mujwara, Jen Kintzle, Paolo Di Domenico, George B Busby, Giordano Bottà
BACKGROUND: Polygenic risk score for coronary artery disease (CAD-PRS) improves precision in assessing the risk of cardiovascular diseases and is cost-effective in preventing cardiovascular diseases in a health system and may be cost-effective in other settings and prevention programs such as workplace cardiovascular prevention programs. Workplaces provide a conducitve environment for cardiovascular prevention interventions, but the cost-effectiveness of CAD-PRS in a workplace setting remains unknown...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37489210/from-studio-to-rehab-a-debilitating-form-of-anti-hmgcr-myopathy
#35
Comfort Anim-Koranteng, Okeoghene Akpoigbe, Michael Miller, Yelena Averbukh
Immune-mediated necrotizing myopathy is a subtype of immune-mediated myopathy associated with or without statin use. Statins, or HMG-CoA reductase inhibitors, are the most prescribed medications for dyslipidemia. The statin-associated myopathic syndromes range from asymptomatic elevations in creatine kinase to severe debilitating muscle weakness with associated rhabdomyolysis and elevated liver enzymes. Clinical improvement occurs upon discontinuation of statins, but some patients do not recover completely...
June 2023: Curēus
https://read.qxmd.com/read/37465805/chronic-anti-hmg-coa-reductase-positive-necrotizing-myositis-with-remote-exposure-to-statins
#36
Tooba Salar, Massiel Jimenez, Mazin Hameed, Anthony Ocon
The use of statins may be associated with muscle-related side effects ranging from myalgia to rhabdomyolysis. A rare adverse effect is statin-induced anti-hydroxy-3-methyl-glutaryl-coenzyme A reductase (anti-HMGCR) necrotizing myositis, which may develop after exposure to statins due to autoantibodies against HMG-Co-A reductase. We present the case of a 76-year-old male who developed progressive muscle weakness three years after exposure to statins. He had significantly elevated creatine kinase (CK) levels, despite the discontinuation of statins three years prior...
June 2023: Curēus
https://read.qxmd.com/read/37451842/rosuvastatin-induced-rhabdomyolysis-case-report-and-call-for-proactive-multifactorial-risk-assessment-and-preventive-management-of-statin-therapy-in-high-risk-patients
#37
JOURNAL ARTICLE
David Franklin Niedrig, Martin Pyra, Roger Lussmann, Andreas Serra, Stefan Russmann
Cholesterol-lowering statins are frequently prescribed for primary and secondary prevention of ischaemic vascular events. Whereas most patients tolerate statins without problems, statin-associated myopathy is well documented, as are several risk factors. We present a case report of an 80-90-year-old man with coronary artery disease who rapidly developed severe rhabdomyolysis during treatment with rosuvastatin while in intensive care. He had several concomitant risk factors for statin-induced myopathy including high dosage, old age, renal and hepatic impairment, and a pharmacogenetic SLCO1B1*1 a/*5 variant...
July 14, 2023: European Journal of Hospital Pharmacy. Science and Practice
https://read.qxmd.com/read/37425714/tomm40-and-tomm22-of-the-translocase-outer-mitochondrial-membrane-complex-rescue-statin-impaired-mitochondrial-dynamics-morphology-and-mitophagy-in-skeletal-myotubes
#38
Neil V Yang, Sean Rogers, Rachel Guerra, David J Pagliarini, Elizabeth Theusch, Ronald M Krauss
BACKGROUND: Statins are the drugs most commonly used for lowering plasma low-density lipoprotein (LDL) cholesterol levels and reducing cardiovascular disease risk. Although generally well tolerated, statins can induce myopathy, a major cause of non-adherence to treatment. Impaired mitochondrial function has been implicated as a cause of statin-induced myopathy, but the underlying mechanism remains unclear. We have shown that simvastatin downregulates transcription of TOMM40 and TOMM22 , genes that encode major subunits of the translocase of outer mitochondrial membrane (TOM) complex which is responsible for importing nuclear-encoded proteins and maintaining mitochondrial function...
June 26, 2023: bioRxiv
https://read.qxmd.com/read/37417539/impact-of-metformin-on-statin-associated-myopathy-risks-in-dyslipidemia-patients
#39
JOURNAL ARTICLE
Keunhyeong Bak, Suhyeon Moon, Minjung Ko, Yeo Jin Choi, Sooyoung Shin
A growing number of patients with metabolic disorders are receiving statin and antidiabetic therapies as comedications. A signal of increased risk of myotoxicity due to potential interactions between antidiabetics and statins has been detected in previous studies. To investigate the effects of metformin on myopathy risks when added to preexisting statin therapy in dyslipidemia patients, we performed a retrospective cohort study using the Korean national health insurance data in statin-treated dyslipidemia patients with or without concomitant metformin use...
August 2023: Pharmacology Research & Perspectives
https://read.qxmd.com/read/37381157/statin-therapy-induces-gut-leakage-and-neuromuscular-disjunction-in-patients-with-chronic-heart-failure
#40
JOURNAL ARTICLE
Firdos Ahmad, Asima Karim, Javaidullah Khan, Rizwan Qaisar
Statins are commonly used to limit the risk of cardiovascular diseases, including ischemic heart attack and stroke. However, treatment often leads to myopathy and muscle weakness. Therefore, a better understanding of underlying pathomechanism is needed to improve the clinical outcomes. Here we assessed the physical performance, including handgrip strength (HGS), gait speed (GS), and short physical performance battery (SPPB) in 172 patients diagnosed with chronic heart failure (CHF) treated with (n=50) or without (n=122) statin, and 59 controls...
June 27, 2023: Journal of Cardiovascular Pharmacology
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