keyword
MENU ▼
Read by QxMD icon Read
search

potassium amphotericine

keyword
https://www.readbyqxmd.com/read/27896234/frequency-and-associated-factors-of-amphotericin-b-nephrotoxicity-in-hospitalized-patients-in-hematology-oncology-wards-in-the-southwest-of-iran
#1
Iman Karimzadeh, Marziyeh Heydari, Mani Ramzi, Mohammad Mahdi Sagheb
BACKGROUND: Nephrotoxicity is the most clinically significant adverse reaction of amphotericin B. Different aspects of amphotericin B (AmB) nephrotoxicity have not been studied well in our population. OBJECTIVES: The purpose of this study was to assess the frequency, time onset, and possible associated factors of AmB nephrotoxicity in hospitalized patients in hematology-oncology wards in the southwest of Iran. PATIENTS AND METHODS: A cross-sectional, observational study was performed over a period of 9 months at 2 hematology-oncology and 1 hematopoietic stem cell transplantation wards at Namazi Hospital...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27771622/refractory-sporotrichosis-due-to-sporothrix-brasiliensis-in-humans-appears-to-be-unrelated-to-in-vivo-resistance
#2
Rodrigo Almeida-Paes, Manoel Marques Evangelista Oliveira, Dayvison Francis Saraiva Freitas, Antônio Carlos Francesconi do Valle, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira
Sporotrichosis is a subacute to chronic infection caused by members of the Sporothrix schenckii complex. Itraconazole is the first choice antifungal drug for treating this infection, with terbinafine and potassium iodide as alternatives and amphotericin B used in cases of severe infections. Correlation of antifungal susceptibility data with the clinical outcome of the patients is scarce. The aim of this study was to correlate clinical and mycological data in patients with refractory sporotrichosis. In this work, antifungal susceptibilities, determined according to the reference M38-A2 CLSI protocol, of 25 Sporothrix strains, isolated from seven human cases of sporotrichosis with adversities in the treatment, are presented...
October 22, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27724891/safety-and-efficacy-of-liposomal-amphotericin-b-for-treatment-of-complicated-visceral-leishmaniasis-in-patients-without-hiv-north-west-ethiopia
#3
Aschalew Tamiru, Bethlehem Tigabu, Sisay Yifru, Ermias Diro, Asrat Hailu
BACKGROUND: Visceral leishmaniasis (VL) is a protozoan disease that is invariably fatal if left untreated. The disease is found in 70 countries with incidence of 0.2 - 0.4 million cases. The mainstay of treatment in resource limited countries like Ethiopia is antimonials, while use of liposomal amphotericin B is reserved for treatment of complicated VL cases. The aim of this study was to assess the safety and efficacy of liposomal amphotericin B in HIV negative VL patients diagnosed with complications...
October 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27467556/prevalence-and-hospital-management-of-amphotericin-b-deoxycholate-related-toxicities-during-treatment-of-hiv-associated-cryptococcal-meningitis-in-south-africa
#4
Susan Meiring, Melony Fortuin-de Smidt, Ranmini Kularatne, Halima Dawood, Nelesh P Govender
BACKGROUND: We aimed to establish the prevalence of amphotericin B deoxycholate (AmBd)-related toxicities among South African patients with cryptococcosis and determine adherence to international recommendations to prevent, monitor and manage AmBd-related toxicities. METHODS: Clinical data were collected from cases of laboratory-confirmed cryptococcosis at 25 hospitals, October 2012 -February 2013. Anemia was defined as hemoglobin (Hb) concentration <10 g/dl, hypokalemia as serum potassium (K) <3...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27376878/gastro-intestinal-basidiobolomycosis-in-a-2-year-old-boy-dramatic-response-to-potassium-iodide
#5
Anahita Sanaei Dashti, Amir Nasimfar, Hossein Hosseini Khorami, Gholamreza Pouladfar, Mohammad Rahim Kadivar, Bita Geramizadeh, Masoomeh Khalifeh
Gastro-intestinal basidiobolomycosis (GIB) is a rare fungal infection caused by Basidiobolus ranarum. Treatment includes surgical resection and long-term antifungal therapy. A 2.5-year-old boy presented with a 10-day history of abdominal pain, fever and diarrhoea, and a palpable abdominal mass was detected. Resection was undertaken and histology confirmed basidiobolomycosis. Treatment with amphotericin B and itraconazole was commenced, but the infection progressed and spread to involve the intestines, liver, ribs and lung, and also the abdominal wall after 6 months, requiring four operative procedures...
July 4, 2016: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/26880338/chaetomium-atrobrunneum-and-aspergillus-fumigatus-in-multiple-tracheal-aspirates-copathogens-or-symbiosis
#6
He Wang, Yali Liu, Sharon C-A Chen, Yun Long, Fanrong Kong, Ying-Chun Xu
Chaetomium atrobrunneum has never been reported to be associated with pneumonia. We report the isolation of C. atrobrunneum and Aspergillus fumigatus from a Chinese elderly patient with fatal pneumonia. Branched, long, and septate hyphae were observed in potassium hydroxide preparations and Gram-stained smears, and confluent C. atrobrunneum growth and a few A. fumigatus colonies were found in tracheal aspirates (nine separate occasions). These isolates were identified by conventional morphological methods and by sequencing the internal transcribed spacer and the D1/D2 domain of the 26S rRNA gene...
April 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/26870686/exploration-of-the-anticandidal-mechanism-of-cassia-spectabilis-in-debilitating-candidiasis
#7
Angeline Torey, Soundararajan Vijayarathna, Subramanion L Jothy, Sivapragasam Gothai, Yeng Chen, Lachimanan Yoga Latha, Jagat R Kanwar, Saravanan Dharmaraj, Sreenivasan Sasidharan
Candida albicans has become resistant to the commercially available, toxic, and expensive anti-Candida agents that are on the market. These factors force the search for new antifungal agents from natural resources. Cassia spectabilis had been traditionally employed by healers for many generations. The possible mechanisms of the C. spectabilis leaf extract were determined by potassium leakage study and the effect of the extract on the constituents of the cell wall and enzymes as well as the morphological changes on C...
January 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/26761695/prevention-of-amphotericin-b-nephrotoxicity-through-use-of-phytotherapeutic-medication
#8
Fábio Dos Santos Schlottfeldt, Sheila Marques Fernandes, Daniel Malisani Martins, Priscilla Cordeiro, Cassiane Dezoti da Fonseca, Mirian Watanabe, Maria de Fatima Fernandes Vattimo
Objective To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated...
February 2015: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/26645511/pharmacokinetic-evaluation-of-liposomal-amphotericin-b-l-amb-in-patients-with-invasive-fungal-infection-population-approach-in-japanese-pediatrics
#9
MULTICENTER STUDY
Yuka Ohata, Yoshiko Tomita, Kota Suzuki, Takashi Maniwa, Yoshitaka Yano, Keisuke Sunakawa
UNLABELLED: The pharmacokinetic characteristics of liposomal amphotericin B (L-AMB; AmBisome(®)) in patients with invasive fungal infection were investigated. A population pharmacokinetic (PK) model in Japanese pediatric patients was developed based on 159 serum amphotericin B (AMPH-B) concentrations obtained in a post-marketing clinical study. The subjects were 39 patients with a mean age of 8.4 years (SD 4.5) and mean body weight of 27.1 kg (SD 14.1). A two-compartment PK model with zero-order input and first-order elimination was fitted to serum AMPH-B concentrations for L-AMB doses of 1...
December 2015: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/26537212/morphological-and-physiological-comparison-of-taxa-comprising-the-sporothrix-schenckii-complex
#10
Ming-dan Zhao, Xun Zhou, Ting-ting Liu, Zhi-bang Yang
Based on recent molecular data, it has been suggested that Sporothrix globosa is the main causal agent of sporotrichosis in China. The objective of this study was to compare the morphology, growth characteristics, patterns of carbon source usage, and susceptibility to antifungal agents among Sporothrix strains. A total of 15 clinical strains confirmed to be S. globosa, from three different regions of China, and 11 ex-type strains from the CBS-KNAW biodiversity center were obtained. The elongated conidia of S...
November 2015: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/26170185/changing-epidemiology-of-mucoralean-fungi-chronic-cutaneous-infection-caused-by-mucor-irregularis
#11
Jagdish Chander, Mandeep Kaur, Mala Bhalla, Rajpal Singh Punia, Nidhi Singla, Kalyani Bhola, Ana Alastruey-Izquierdo, Alberto M Stchigel, Josep Guarro
INTRODUCTION: The fungi pertaining to order Mucorales usually cause an acute form of clinical disease called mucormycosis. A primary chronic presentation in an immunocompetent patient is a rare form of mucormycosis. Mucor irregularis is known for causing chronic cutaneous infections geographically confined to Asia, mainly in China. We describe a case of primary chronic cutaneous mucormycosis caused by M. irregularis from a new geographical niche in India, highlighting changing aspects of its epidemiology...
October 2015: Mycopathologia
https://www.readbyqxmd.com/read/25734140/standardized-electrolyte-supplementation-and-fluid-management-improves-survival-during-amphotericin-therapy-for-cryptococcal-meningitis-in-resource-limited-settings
#12
Nathan C Bahr, Melissa A Rolfes, Abdu Musubire, Henry Nabeta, Darlisha A Williams, Joshua Rhein, Andrew Kambugu, David B Meya, David R Boulware
BACKGROUND: Amphotericin B is the preferred treatment for cryptococcal meningitis, but it has cumulative severe side effects, including nephrotoxicity, hypokalemia, and hypomagnesemia. Amphotericin-induced severe hypokalemia may predispose the patient to cardiac arrhythmias and death, and there is very little data available regarding these toxicities in resource-limited settings. We hypothesized that standardized electrolyte management during amphotericin therapy is essential to minimize toxicity and optimize survival in sub-Saharan Africa...
September 2014: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/25614735/sporotrichosis-an-overview-and-therapeutic-options
#13
REVIEW
Vikram K Mahajan
Sporotrichosis is a chronic granulomatous mycotic infection caused by Sporothrix schenckii, a common saprophyte of soil, decaying wood, hay, and sphagnum moss, that is endemic in tropical/subtropical areas. The recent phylogenetic studies have delineated the geographic distribution of multiple distinct Sporothrix species causing sporotrichosis. It characteristically involves the skin and subcutaneous tissue following traumatic inoculation of the pathogen. After a variable incubation period, progressively enlarging papulo-nodule at the inoculation site develops that may ulcerate (fixed cutaneous sporotrichosis) or multiple nodules appear proximally along lymphatics (lymphocutaneous sporotrichosis)...
2014: Dermatology Research and Practice
https://www.readbyqxmd.com/read/25596015/heart-failure-duration-progressively-modulates-the-arrhythmia-substrate-through-structural-and-electrical-remodeling
#14
Victor P Long, Ingrid M Bonilla, Pedro Vargas-Pinto, Yoshinori Nishijima, Arun Sridhar, Chun Li, Kent Mowrey, Patrick Wright, Murugesan Velayutham, Sanjay Kumar, Nam Y Lee, Jay L Zweier, Peter J Mohler, Sandor Györke, Cynthia A Carnes
AIMS: Ventricular arrhythmias are a common cause of death in patients with heart failure (HF). Structural and electrical abnormalities in the heart provide a substrate for such arrhythmias. Canine tachypacing-induced HF models of 4-6 weeks duration are often used to study pathophysiology and therapies for HF. We hypothesized that a chronic canine model of HF would result in greater electrical and structural remodeling than a short term model, leading to a more arrhythmogenic substrate...
February 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/25569595/diagnosis-and-treatment-of-cerebral-salt-wasting-syndrome-with-cryptococcal-meningitis-in-hiv-patient
#15
Sunggeun Lee, Anitsira Collado, Montish Singla, Roger Carbajal, Ashok Chaudhari, Donald Baumstein
Hyponatremia is one of the most common electrolyte imbalances in HIV patients. The differential diagnosis may include hypovolemic hyponatremia, syndrome of inappropriate antidiuretic hormone secretion (SIADH), and adrenal insufficiency. Here, we describe a case of hyponatremia secondary to cerebral salt wasting syndrome (CSWS) in an HIV patient with cryptococcal meningitis. A 52-year-old man with a history of diabetes and HIV was admitted for headache and found to have cryptococcal meningitis. He was also found to have asymptomatic hyponatremia...
March 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/25557523/a-new-look-at-the-antibiotic-amphotericin-b-effect-on-candida-albicans-plasma-membrane-permeability-and-cell-viability-functions
#16
Barbara Chudzik, Mateusz Koselski, Aleksandra Czuryło, Kazimierz Trębacz, Mariusz Gagoś
Amphotericin B (AmB) is an antifungal polyene for which the most accepted mode of action is formation of protein-like ion channels in the cell membrane. Patch-clamp research on Candida albicans protoplasts carried out in the outside-out configuration showed that application of 0.05 and 0.1 μM AmB caused a decrease in seal resistance. Such a phenomenon can be correlated with a decrease in membrane tightness. AmB applied at a 0.05 μM concentration also caused a decrease in the number of active TOK1 (two-pore outward rectifiers) potassium channels, but did not significantly change their open probability...
February 2015: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/25550388/toxicity-and-efficacy-differences-between-liposomal-amphotericin-b-formulations-in-uninfected-and-aspergillus-fumigatus-infected-mice
#17
COMPARATIVE STUDY
J A Olson, J A Schwartz, D Hahka, N Nguyen, T Bunch, G M Jensen, J P Adler-Moore
Because of the reduced toxicity associated with liposomal amphotericin B preparations, different amphotericin B liposome products have been made. In the present study, we compared the amphotericin B liposomal formulations, AmBisome(®) (AmBi) and Lambin(®) (Lbn), in uninfected and Aspergillus fumigatus infected mice, using several in vitro and in vivo toxicity and efficacy assays. The results showed that the formulations were significantly different, with Lbn 1.6-fold larger than AmBi. Lbn was also more toxic than AmBi based on the RBC potassium release assay and intravenous dosing in uninfected mice given a single 50 mg/kg dose (80% mortality for Lbn vs...
February 1, 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/25541558/in-vitro-inhibitory-activity-of-terpenic-derivatives-against-clinical-and-environmental-strains-of-the-sporothrix-schenkii-complex
#18
Raimunda Sâmia Nogueira Brilhante, Natalya Fechine Silva, Francisca Jakelyne de Farias Marques, Débora de Souza Collares Maia Castelo-Branco, Rita Amanda Chaves de Lima, Angela Donato Maia Malaquias, Erica Pacheco Caetano, Giovanna Riello Barbosa, Zoilo Pires de Camargo, Anderson Messias Rodrigues, André Jalles Monteiro, Tereza de Jesus Pinheiro Gomes Bandeira, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, José Luciano Bezerra Moreira, Marcos Fábio Gadelha Rocha
Sporotrichosis is a subacute or chronic subcutaneous infection, caused by the fungus Sporothrix schenkii complex, occurring in human and animal tissues. Potassium iodide and itraconazole have been used as effective therapy for first-choice treatment, while amphotericin B may be indicated for disseminated infection. However, the adverse effects of potassium iodide and amphotericin B or the long duration of therapy with itraconazole often weigh against their use, leading to the search for alternatives for the treatment of severe infections...
February 1, 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/25477076/feline-sporotrichosis-epidemiological-and-clinical-aspects
#19
REVIEW
Isabella D F Gremião, Rodrigo C Menezes, Tânia M P Schubach, Anna B F Figueiredo, Maíra C H Cavalcanti, Sandro A Pereira
Feline sporotrichosis, which is caused by species of the Sporothrix schenckii complex, is endemic to Rio de Janeiro, Brazil. More than 4000 cases of the disease were diagnosed at Fundação Oswaldo Cruz, Brazil, between 1998 and 2012. Sporotrichosis in cats has been reported in several countries, but nowhere has an outbreak of animal sporotrichosis been as large as that seen in Brazil. The clinical manifestations of the disease range from an isolated skin lesion that can progress to multiple skin lesions and even fatal systemic involvement...
January 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/25377138/human-fungal-pathogens-of-mucorales-and-entomophthorales
#20
REVIEW
Leonel Mendoza, Raquel Vilela, Kerstin Voelz, Ashraf S Ibrahim, Kerstin Voigt, Soo Chan Lee
In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota...
November 6, 2014: Cold Spring Harbor Perspectives in Medicine
keyword
keyword
100654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"