keyword
https://read.qxmd.com/read/38299805/elevation-of-depressed-skull-fracture-in-neonates-using-a-breast-pump-and-a-custom-molded-flange
#21
JOURNAL ARTICLE
Emilie L Martinez, Ashley Welscher, Manish N Shah, David I Sandberg
BACKGROUND AND IMPORTANCE: "Ping-pong fractures" (PPF) can occur in neonates and result in cosmetic deformity and local mass effect. Standard treatment involves surgical elevation of the depressed bone when the indentation is considerable or cosmetically apparent. Surgical correction of PPF subjects patients to the risks of surgery and general anesthesia. This article and corresponding video demonstrate a novel means of correcting PPF at bedside without surgery or anesthesia. We used a hospital-grade breast pump connected to a custom-fabricated flange to successfully elevate PPF in two neonates...
February 1, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38291934/-top-5-research-studies-of-the-month-for-italian-primary-care-physicians-january-2024
#22
JOURNAL ARTICLE
Peter K Kurotschka, Alice Serafini, Mark H Ebell
This monthly article provides a collection of summaries of the most relevant studies identified as POEMs (patient-oriented evidence that matters) for Italian primary care physicians. 1) A recent high-quality systematic review (SR) of 76 SRs found that, compared to all other lipid-lowering medications, for overall, primary, and secondary prevention the best balance of benefits, harms, and costs is provided by statins. 2) To our surprise, a network meta-analysis of 12 randomized controlled trials (RCTs) concluded that acetaminophen and ketorolac were more effective than morphine in alleviating pain from renal colic and were less likely than morphine to cause adverse effects and the need for rescue analgesia...
February 2024: Recenti Progressi in Medicina
https://read.qxmd.com/read/38284677/left-atrial-strain-is-reduced-following-trastuzumab-in-breast-cancer-patients
#23
JOURNAL ARTICLE
Mats C Højbjerg Lassen, Farzin Arya, Tor Biering-Sørensen, Jacob L T Reeh, Michelle E Melisko, Shabir Sarwary, Alan H Baik, Mandar A Aras, Atif Qasim
BACKGROUND: The effect of trastuzumab therapy on left atrial (LA) function remains largely unknown. Our aim was to assess the changes in LA strain parameters longitudinally in patients treated with trastuzumab. METHODS: We retrospectively studied 170 patients with stage I-IV HER2+ breast cancer. All patients had baseline echocardiograms and repeat echocardiograms at 3 months and after 1 year. We measured LA strain at all three time points. Changes in LA strain and strain rate (sr) parameters were evaluated using repeated-measures mixed-effects models...
January 2024: Echocardiography
https://read.qxmd.com/read/38284386/dual-loaded-liposomal-carriers-to-combat-chemotherapeutic-resistance-in-breast-cancer
#24
REVIEW
Mohamed El-Tanani, Hamdi Nsairat, Alaa A Aljabali, Ismail I Matalka, Alaaldin M Alkilany, Murtaza M Tambuwala
INTRODUCTION: The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses the potential of dual-loaded liposomal carriers to combat chemoresistance and improve outcomes for breast cancer patients. AREAS COVERED: This review discusses breast cancer chemotherapy resistance and dual-loaded liposomal carriers. Drug efflux pumps, DNA repair pathways, and signaling alterations are discussed as chemoresistance mechanisms...
January 29, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38271767/electroencephalographic-activity-during-direct-breastfeeding-and-breast-milk-expression-in-primiparous-mothers
#25
JOURNAL ARTICLE
M Pérez-Hernández, J P García-Hernández, R M Hidalgo-Aguirre, M A Guevara, F A Robles-Aguirre, M Hernández-González
Breastfeeding is recognized worldwide as the best option for infant feeding. Expressing breast milk is an alternative for mothers to provide their infants all the benefits of maternal milk. During breast milk expression, mothers receive a distinct kind of sensory stimulation, because there is no direct bodily or affective interaction with their infants, many women report feeling isolated, generating a love-hate relation with pumping, and even low levels of satisfaction while expressing breast milk. While it is well known that the prefrontal, parietal, and temporal cortices play important roles in the emotional and cognitive processing of maternal stimuli, knowledge about how these cortical areas function during breastfeeding is lacking...
January 20, 2024: Early Human Development
https://read.qxmd.com/read/38252450/premarket-notifications-and-patents-for-breast-pumps-before-and-after-the-aca
#26
JOURNAL ARTICLE
Oluwarantimi Adetunji, Pallavi Pemmireddy, Trinidad Beleche, Sonal Parasrampuria
No abstract text is available yet for this article.
January 22, 2024: JAMA
https://read.qxmd.com/read/38244190/use-of-pharmacokinetic-and-pharmacodynamic-data-to-develop-the-cdk4-6-inhibitor-ribociclib-for-patients-with-advanced-breast-cancer
#27
REVIEW
Yan Ji, Hilmar Schiller, Shu Yang, Michelle Quinlan, Christelle Darstein, Felix Huth, Serge Winter, Abhijit Chakraborty
Ribociclib is an orally bioavailable, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. CDK4/6 inhibition by ribociclib leads to retinoblastoma tumor suppressor protein (Rb) reactivation, thereby restoring Rb-mediated cell cycle arrest. Ribociclib is approved for the treatment of patients with hormone receptor-positive/human epidermal growth factor receptor-2-negative (HR+/HER2-) advanced breast cancer (ABC), at the dose of 600 mg once daily (QD) during cycles of 21 days on/7 days off, with optional dose reduction to 400 mg and 200 mg...
January 20, 2024: Clinical Pharmacokinetics
https://read.qxmd.com/read/38241129/milk-biomarkers-of-secretory-activation-in-breast-pump-dependent-mothers-of-preterm-infants-an-integrative-review
#28
REVIEW
Leslie A Parker, Rebecca Hoban, Marion M Bendixen, Clarisa Medina-Poeliniz, Tricia J Johnson, Paula P Meier
Background: Lack of mother's own milk (MOM) at discharge from the neonatal intensive care unit (NICU) is a global problem and is often attributable to inadequate MOM volume. Evidence suggests that the origins of this problem are during the first 14 days postpartum, a time period that includes secretory activation (SA; lactogenesis II, milk coming in ). Objectives: To describe and summarize evidence regarding use of MOM biomarkers (MBMs) as a measure of SA in pump-dependent mothers of preterm infants in the NICU and to identify knowledge gaps requiring further investigation...
January 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38235759/influence-of-donor-characteristics-on-the-milk-donation-volume-and-microbiological-quality-of-donated-human-milk-in-first-3-years-of-work-of-the-croatian-human-milk-bank-retrospective-observational-study
#29
JOURNAL ARTICLE
Jurjana Novoselac, Branka Golubić Ćepulić, Barbara Kalenić, Anita Pavičić Bošnjak
OBJECTIVES: Donated human milk is the best possible alternative when mother's own milk is not available. The aim of this study is to investigate whether there are differences in the milk donation volumes and microbiological quality of donated milk depending on human milk donors (HMDs) characteristics. METHODS: We analyzed data on the HMDs who donated milk in first three years of work of human milk bank (HMB) - November 2019 to January 2023. The data on the volume of donated milk in L and suitable microbiological quality assessed by the number and isolated species of bacteria were collected from questionnaires filled out by HMDs and documentation administered by HMB employees and are presented using descriptive and comparative statistics...
January 19, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38225606/effect-of-ultrasound-guided-continuous-erector-spinae-plane-block-on-postoperative-pain-and-inflammatory-response-in-patients-undergoing-modified-radical-mastectomy-for-breast-cancer-study-protocol-for-a-randomised-controlled-trial
#30
JOURNAL ARTICLE
Liang Yu, Xiao-Juan Shen, He Liu, Yu-Ting Zhou, Qin Zhang, Zhen-Duo Zhang, Shu-Min Shen
BACKGROUND: A single injection of local anaesthetic (LA) in the erector spinae plane block (ESPB) can reduce pain after modified radical mastectomy (MRM) surgery, but the duration of analgesia is affected by the duration of the LA. The aim of this study is to investigate the effect of continuous ESPB on acute and chronic pain and inflammatory response after MRM surgery. METHODS: In this prospective, randomised, controlled trial, we will recruit 160 patients, aged 18-80 years, scheduled for elective MRM surgery under general anaesthesia...
January 15, 2024: Trials
https://read.qxmd.com/read/38213472/development-of-a-cost-effective-compact-diode-laser-based-photoacoustic-sensing-instrument-for-breast-tissue-diagnosis
#31
JOURNAL ARTICLE
Suhel Khan, Sramana Mukhopadhyay, Srivathsan Vasudevan, Garima Goel, Deepti Joshi, Neelkamal Kapoor, Saikat Das
SIGNIFICANCE: The photoacoustic (PA) technique, a noninvasive pump-probe technique, has found interesting applications in biomedical tissue diagnosis over the last decade. To take it a step further to clinical applications, the PA technique needs to be designed as an instrument focusing on a compact design, reducing the cost, and quickly providing a quantitative diagnosis. AIM: This work presents a design and characterization of a cost-effective, compact PA sensing instrument for biomedical tissue diagnosis...
January 2024: Journal of Biomedical Optics
https://read.qxmd.com/read/38192365/effect-of-personality-and-pain-catastrophizing-on-postoperative-analgesia-following-cesarean-section-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Yunhong Ren, Yinhao Guo, Jing Tang, Ling He, Meiling Li, Xuemei Huang, Qin Lu, Baoxia Sun, Haixia Feng, Huan Liu, Juan Du, Jun Li
PURPOSE: This study aimed to investigate the effects of different psychological personalities and pain catastrophizing levels on postoperative analgesia in patients undergoing cesarean section. PATIENTS AND METHODS: Puerperas who underwent cesarean section at our hospital between January and August 2023 were recruited into the study and assessed using the Eysenck Personality Questionnaire-Revised Short Scale (EPQRSC) and Pain Catastrophizing Scale (PCS). Data on the numerical pain intensity at rest and during activity 24 h after surgery, number and dosage of analgesia pumps, and satisfaction with analgesia were recorded...
2024: Journal of Pain Research
https://read.qxmd.com/read/38191870/human-milk-oligosaccharides-and-the-association-with-microbiota-in-colostrum-a-pilot-study
#33
JOURNAL ARTICLE
Wen Sun, Lin Tao, Chen Qian, Peipei Xue, Xiankun Tong, Li Yang, Fang Lu, Hua Wan, Yingna Tao
HMOs (Human milk oligosaccharide) has an impact on maternal and infant health. Colostrum samples of 70 breastfeeding women in China were collected and recorded clinical characteristics. The major oligosaccharides and microbiota were quantitated in colostrum. The concentration of fucosylated HMOs in primipara was higher than that of multipara (p = 0.030). The concentration of N-acetylated HMOs in vaginal delivery milk was less than that of cesarean (p = 0.038). Non-fucosylated HMOs of breastfeeding women were less than that of breast pump (p = 0...
January 8, 2024: Archives of Microbiology
https://read.qxmd.com/read/38191497/breastfeeding-support-among-re-hospitalized-young-children-a-survey-from-italy
#34
JOURNAL ARTICLE
Elena Scarpato, Guglielmo Salvatori, Michelangelo Barbaglia, Deborah Casero, Teresa Cazzato, Veronica Righetti, Annamaria Staiano, Riccardo Davanzo
BACKGROUND: In 2021, the Task Force on Breastfeeding of the Italian Ministry of Health released a document calling for the provision of breastfeeding support in case of re-hospitalization of the child after birth. Since type and quality of breastfeeding support during re-hospitalization in Italian Pediatric Units (PUs) is largely unknown, the Breastfeeding Section of the Italian Society of Pediatrics (TASIP) conducted an ad hoc national survey. METHODS: In March 2023, a specifically designed electronic questionnaire was sent to the Directors of 328 PUs, who were requested to fill it online...
January 8, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38153096/the-conception-and-birth-of-the-lactation-consultant-profession-1977-1983-an-interview-with-chele-marmet-part-i
#35
JOURNAL ARTICLE
Chele Marmet, Joan E Dodgson
In 2015, Miriam Labbok, MD, MPH, entrusted Chele Marmet with the task of writing a chapter on the early history of the lactation consultant profession for the public health textbook she was preparing about lactation, saying, "I invited you to author it because you conceptualized and pioneered the profession, and there is nobody else I could ask who could do it justice," (M. Labbok, personal communication, June 28, 2015). Chele Marmet envisioned the allied health field of lactation consulting, complete with international educational standards, professional organizations, and a scope of practice...
December 28, 2023: Journal of Human Lactation
https://read.qxmd.com/read/38152415/examining-the-efficacy-of-treatments-for-arm-lymphedema-in-breast-cancer-survivors-an-overview-of-systematic-reviews-with-meta-analyses
#36
JOURNAL ARTICLE
Bolette Skjødt Rafn, Anne Bodilsen, Annika von Heymann, Maja Johannsen Lindberg, Sofia Byllov, Tine Ginnerup Andreasen, Christoffer Johansen, Peer Christiansen, Robert Zachariae
BACKGROUND: Lymphedema affects one in six breast cancer survivors making it a global healthcare challenge. There is considerable debate about the efficacy of different treatments for lymphedema. We aimed to summarize the current evidence for treatments for lymphedema in breast cancer survivors. METHODS: In this overview of systematic reviews with meta-analyses (SRMAs), five databases were searched for SRMAs of randomised controlled trials (RCTs) reporting effects of medications, surgery, exercise, laser therapy, acupuncture, kinesio taping, or complex decongestive physiotherapy (CDP) for breast cancer-related lymphedema published from database inception up to March 7, 2023...
January 2024: EClinicalMedicine
https://read.qxmd.com/read/38104849/combating-multidrug-resistance-of-breast-cancer-with-ginsenoside-rh2-irrigated-nano-in-thermogel
#37
JOURNAL ARTICLE
Jieyu Long, Wanshan Hu, Tao Ren, Xuewen Wang, Chao Lu, Xin Pan, Chuanbin Wu, Tingting Peng
The emergence of multidrug resistance (MDR) is the leading cause of mortality in patients with breast cancer. Overexpressed P-glycoprotein (P-gp) that can pump out chemotherapeutics from multidrug-resistant cancer cells is the main cause of chemotherapy failure. P-gp inhibitors are hence increasingly used to sensitize chemotherapy to breast cancer with MDR by reducing the efflux of drugs. However, representative P-gp inhibitors usually have severe side effects and the effect of their release behavior on chemotherapy are neglected in current studies...
December 15, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/38101600/amino-acid-derivative-of-probenecid-potentiates-apoptosis-inducing-effects-of-vinblastine-by-increasing-oxidative-stress-in-a-cancer-cell-specific-manner
#38
JOURNAL ARTICLE
Johanna Huttunen, Janne Tampio, Juulia Järvinen, Ahmed B Montaser, Magdalena Markowicz-Piasecka, Kristiina M Huttunen
Many chemotherapeutic drugs suffer from multidrug resistance (MDR). Efflux transporters, namely ATP-binding cassettes (ABCs), that pump the drugs out of the cancer cells comprise one major reason behind MDR. Therefore, ABC inhibitors have been under development for ages, but unfortunately, without clinical success. In the present study, an L-type amino acid transporter 1 (LAT1)-utilizing derivative of probenecid (PRB) was developed as a cancer cell-targeted efflux inhibitor for P-glycoprotein (P-gp), breast cancer resistant protein (BCRP) and/or several multidrug resistant proteins (MRPs), and its ability to increase vinblastine (VBL) cellular accumulation and apoptosis-inducing effects were explored...
December 13, 2023: Chemico-biological Interactions
https://read.qxmd.com/read/38078440/resiliency-in-breastfeeding-and-lactation-research-a-conversation-about-scholastic-transparency-bias-and-systems-of-support
#39
EDITORIAL
Ellen Chetwynd
No abstract text is available yet for this article.
December 11, 2023: Journal of Human Lactation
https://read.qxmd.com/read/38055460/continuing-breastfeeding-upon-returning-to-work-feelings-challenges-and-strategies-of-breastfeeding-nurses
#40
JOURNAL ARTICLE
Lourdes Maria Nunes Almeida, Maithê de Carvalho E Lemos Goulart, Fernanda Garcia Bezerra Góes, Fernanda Maria Vieira Pereira-Ávila, Carina Bulcão Pinto, Aline Cerqueira Santos Santana da Silva, Luana Ramos Garcia, Larissa Sousa Oliva Brun
OBJECTIVE: To describe feelings, challenges and strategies related to the continuity of breastfeeding after returning to work in the perception of lactating nurses. METHOD: Descriptive, exploratory, qualitative study, with snowball sampling. Data collection occurred virtually between August and September 2020 in the State of Rio de Janeiro. Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires software and a thematic analysis were used...
2023: Revista Gaúcha de Enfermagem
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