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https://www.readbyqxmd.com/read/28101405/deep-tissue-photoacoustic-computed-tomography-with-a-fast-and-compact-laser-system
#1
Depeng Wang, Yuehang Wang, Weiran Wang, Dandan Luo, Upendra Chitgupi, Jumin Geng, Yang Zhou, Lidai Wang, Jonathan F Lovell, Jun Xia
Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 - 200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diode-pumped laser used in this study had a miniature footprint (13 × 14 × 7 cm(3)), weighed only 1...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28098816/estrogen-enhances-the-expression-of-the-multidrug-transporter-gene-abcg2-increasing-drug-resistance-of-breast-cancer-cells-through-estrogen-receptors
#2
Fung-Wei Chang, Hueng-Chuen Fan, Jui-Ming Liu, Tai-Ping Fan, Jin Jing, Chia-Ling Yang, Ren-Jun Hsu
BACKGROUND: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding the molecular mechanisms of drug resistance is important for the reasonable design and use of new treatment strategies to effectively confront cancers. RESULTS: In our study, ATP-binding cassette sub-family G member 2 (ABCG2), adenosine triphosphate (ATP) synthase and cytochrome c oxidase subunit VIc (COX6C) were over-expressed more in the MCF-7/MX cell line than in the normal MCF7 cell line...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28094880/milk-ejection-patterns-remain-consistent-during-the-first-and-second-lactations
#3
Hazel Gardner, Jacqueline C Kent, Danielle K Prime, Ching-Tat Lai, Peter E Hartmann, Donna T Geddes
OBJECTIVE: Milk ejection is a critical physiological process for successful lactation in humans and without it little milk can be removed. Individual milk ejection patterns have been shown to remain consistent between breasts at different lactation stages and using different vacuum patterns with an electric breast pump. Little is known about the milk ejection characteristics during the second lactation period in the same mother. The objective of this study was to examine milk ejection characteristics in the same woman over two lactations...
January 17, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28078789/-breastfeeding-without-baby-a-longitudinal-qualitative-investigation-of-how-mothers-perceive-feel-about-and-practice-human-milk-expression
#4
Julia P Felice, Sheela R Geraghty, Caroline W Quaglieri, Rei Yamada, Adriana J Wong, Kathleen M Rasmussen
Most American mothers who produce human milk (HM) now pump in place of some or all feeding at the breast, and most American infants are now fed pumped HM. We aimed to investigate mothers' perceptions of, attitudes toward, and practices for pumping and providing pumped HM. Results related to pumping are reported here. We conducted in-depth, semi-structured interviews among a diverse sample of 20 mothers who pumped, following each from pregnancy through infant HM-feeding cessation up to 1 year postpartum. Data were analyzed using thematic analysis with Atlas...
January 12, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28056181/an-adoptive-mother-who-became-a-human-milk-donor
#5
Beatriz Flores-Antón, Nadia Raquel García-Lara, Carmen Rosa Pallás-Alonso
Inducing lactation in the absence of pregnancy (nonpuerperal lactation) is not always successful and, in many cases, only partial breastfeeding is achieved. Different protocols have been described, but scientific evidence and research are lacking in this area. The authors describe the case of a woman with a history of a miscarriage, for whom the lactation induction process was so effective that she became a milk donor even before she received her adopted child. She had not previously used hormone treatment...
January 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28036031/drug-transporter-expression-and-activity-in-human-hepatoma-huh-7-cells
#6
Elodie Jouan, Marc Le Vée, Claire Denizot, Yannick Parmentier, Olivier Fardel
Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter expression, activity and regulation in human hepatoma HuH-7 cells, in order to determine the potential relevance of these cells for drug transport assays. HuH-7 cells displayed notable multidrug resistance-associated protein (MRP) activity, presumed to reflect expression of various hepatic MRPs, including MRP2...
December 28, 2016: Pharmaceutics
https://www.readbyqxmd.com/read/28006904/resin-glycosides-from-ipomoea-alba-seeds-as-potential-chemosensitizers-in-breast-carcinoma-cells
#7
Sara Cruz-Morales, Jhon Castañeda-Gómez, Daniel Rosas-Ramírez, Mabel Fragoso-Serrano, Gabriela Figueroa-González, Argelia Lorence, Rogelio Pereda-Miranda
Multidrug resistance is the expression of one or more efflux pumps, such as P-glycoprotein, and is a major obstacle in cancer therapy. The use of new potent and noncytotoxic efflux pump modulators, coadministered with antineoplastic agents, is an alternative approach for increasing the success rate of therapy regimes with different drug combinations. This report describes the isolation and structure elucidation of six new resin glycosides from moon vine seeds (Ipomoea alba) as potential mammalian multidrug-resistance-modifying agents...
December 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/28000997/in-cell-activation-of-organo-osmium-ii-anticancer-complexes
#8
Russell J Needham, Carlos Sanchez-Cano, Xin Zhang, Isolda Romero-Canelón, Abraha Habtemariam, Margaret S Cooper, Levente Meszaros, Guy J Clarkson, Philip J Blower, Peter J Sadler
The family of iodido Os(II) arene phenylazopyridine complexes [Os(η(6) -p-cym)(5-R(1) -pyridylazo-4-R(2) -phenyl))I](+) (where p-cym=para-cymene) exhibit potent sub-micromolar antiproliferative activity towards human cancer cells and are active in vivo. Their chemical behavior is distinct from that of cisplatin: they do not readily hydrolyze, nor bind to DNA bases. We report here a mechanism by which they are activated in cancer cells, involving release of the I(-) ligand in the presence of glutathione (GSH)...
December 21, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27984841/does-circadian-variation-of-mothers-affect-macronutrients-of-breast-milk
#9
Aslihan Köse Çetinkaya, Evrim Alyamaç Dizdar, Erbu Yarcı, Fatma Nur Sari, Serife Suna Oguz, Nurdan Uras, Fuat Emre Canpolat
Objective To determine the within-day variation of fat, protein, and carbohydrate content of breast milk. Methods The study was conducted at Zekai Tahir Burak Maternity Teaching Hospital between April 2013 and January 2014. We obtained milk samples from lactating mothers of hospitalized infants through hand expression after breast-feeding or pumping three times a day. A mid-infrared human milk analyzer was used for measuring the macronutrient contents of breast milk samples. Results Lactating mothers of 52 infants (30 preterm, 22 term) were recruited to the study...
December 16, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27966827/safe-and-effective-reversal-of-cancer-multidrug-resistance-using-sericin-coated-mesoporous-silica-nanoparticles-for-lysosome-targeting-delivery-in-mice
#10
Jia Liu, Qilin Li, Jinxiang Zhang, Lei Huang, Chao Qi, Luming Xu, Xingxin Liu, Guobin Wang, Lin Wang, Zheng Wang
Multidrug resistance (MDR) and adverse side effects are the major challenges facing cancer chemotherapy. Here, pH/protease dually responsive, sericin-coated mesoporous silica nanoparticles (SMSNs) for lysosomal delivery of doxorubicin (DOX) to overcome MDR and reduce systemic toxicity are reported. Sericin, a natural protein from silkworm cocoons, is coated onto MSNs as a gatekeeper via pH sensitive imine linkages. The sericin shell prevents the premature leakage of encapsulated DOX from MSNs in extracellular environment...
December 14, 2016: Small
https://www.readbyqxmd.com/read/27965034/the-ins-and-outs-of-calcium-signalling-in-lactation-and-involution-implications-for-breast-cancer-treatment
#11
Felicity M Davis
The mammary epithelium is highly responsive to hormonal and non-hormonal signalling cues for physiological growth, function and tissue remodelling. Whilst steroid hormones freely diffuse across the cell membrane to bind to intracellular hormone receptors, cell-impermeable ligands, including many peptide hormones, growth factors and cytokines, bind to receptors on the plasma membrane and relay their message via the specific activation of intracellular signal transduction pathways. A signalling pathway that is indispensable for decoding many extracellular signals into cellular responses is calcium (Ca(2+))...
December 10, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27902504/a-password-protected-web-site-for-mothers-expressing-milk-for-their-preterm-infants
#12
MaryAnn Blatz, Donna Dowling, Patricia W Underwood, Amy Bieda, Gregory Graham
BACKGROUND: Research has demonstrated that breast milk significantly decreases morbidities that impact length of stay for preterm infants, but there is a need to test interventions to improve breastfeeding outcomes. Since many Americans are using technologies such as the Intranet and smartphones to find health information and manage health, a Web site was developed for mothers who provide breast milk for their preterm hospitalized infants. PURPOSE: This study examined the efficacy of a Web site for mothers to educate them about breast milk expression and assist them in monitoring their breast milk supply...
November 29, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27882659/interventions-for-women-who-have-a-caesarean-birth-to-increase-uptake-and-duration-of-breastfeeding-a-systematic-review
#13
REVIEW
Sarah Beake, Debra Bick, Cath Narracott, Yan-Shing Chang
Rates of breastfeeding uptake are lower after a caesarean birth than vaginal birth, despite caesarean rates increasing globally over the past 30 years, and many high-income countries reporting overall caesarean rates of above 25%. A number of factors are likely to be associated with women's infant feeding decisions following a caesarean birth such as limited postoperative mobility, postoperative pain, and ongoing management of medical complications that may have triggered the need for a caesarean birth. The aim of this systematic review was to evaluate evidence of interventions on the initiation and duration of any and exclusive breastfeeding among women who had a planned or unplanned caesarean birth...
November 24, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27878697/nf%C3%AE%C2%BAbp65-transcription-factor-modulates-resistance-to-doxorubicin-through-abc-transporters-in-breast-cancer
#14
Kobra Velaei, Nasser Samadi, Sina Soltani, Balal Barazvan, Jafar Soleimani Rad
BACKGROUND: Shedding light on chemoresistance biology of breast cancer could contribute to enhance the clinical outcome. Intrinsic or acquired resistance to chemotherapy is a major problem in breast cancer treatment. METHODS AND MATERIALS: The NFκB pathway by siRNAP65 and JSH-23 as a translocational inhibitor of NFκBP65 in the doxorubicin-resistant MCF-7 (MCF-7/Dox) and MCF-7 cells was blocked. Then, the ABC transporter expression and function were assessed by real-time qRT-PCR and flow cytometry, respectively...
November 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27864561/incidence-of-deep-vein-thrombosis-in-patients-undergoing-breast-reconstruction-with-autologous-tissue-transfer
#15
Hisato Konoeda, Takashi Yamaki, Atsumori Hamahata, Masakazu Ochi, Atsuyoshi Osada, Yuki Hasegawa, Miho Kirita, Hiroyuki Sakurai
BACKGROUND: Breast reconstruction is associated with multiple risk factors for venous thromboembolism. However, the incidence of deep vein thrombosis in patients undergoing breast reconstruction is uncertain. OBJECTIVE: The aim of this study was to prospectively evaluate the incidence of deep vein thrombosis in patients undergoing breast reconstruction using autologous tissue transfer and to identify potential risk factors for deep vein thrombosis. METHODS: Thirty-five patients undergoing breast reconstruction were enrolled...
November 17, 2016: Phlebology
https://www.readbyqxmd.com/read/27828726/early-breast-milk-pumping-intentions-among-postpartum-women
#16
Yiska Loewenberg Weisband, Sarah A Keim, Lisa M Keder, Sheela R Geraghty, Maria F Gallo
INTRODUCTION: Milk expression has become common, but little is known about women's intentions and motivations for pumping. Our objectives were to measure, among newly postpartum women, intentions related to breast milk feeding and pumping, reasons for intending to pump, and timing of pumping initiation. METHODS: We conducted a cross-sectional study at a large university hospital in 2015 using a convenience sample of 100 women before their discharge following delivery, who intended to feed their infant breast milk for at least 6 months...
November 9, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27809299/the-v-atpase-a2-isoform-controls-mammary-gland-development-through-notch-and-tgf-%C3%AE-signaling
#17
Sahithi Pamarthy, Liquin Mao, Gajendra K Katara, Sara Fleetwood, Arpita Kulshreshta, Alice Gilman-Sachs, Kenneth D Beaman
Among all tissues and organs, the mammary gland is unique because most of its development occurs in adulthood. Notch signaling has a major role in mammary gland development and has been implicated in breast cancer. The vacuolar-ATPase (V-ATPase) is a proton pump responsible for the regulation and control of pH in intracellular vesicles and the extracellular milieu. We have previously reported that a2V-ATPase (a2V), an isoform of 'a' subunit of V-ATPase, regulates processing of Notch receptor and alters Notch signaling in breast cancer...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27780727/methylation-of-notch3-modulates-chemoresistance-via-p-glycoprotein
#18
Xiaoting Gu, Yangfan Lu, Dongxu He, Chunxiao Lu, Jian Jin, Xiaojie Lu, Xin Ma
The global gene expression and DNA methylation of genes in adriamycin-resistant human breast cancer cells (MCF-7/ADM cells) are similar to those in paclitaxel-resistant MCF-7 cells (MCF-7/PTX) and are significantly different from those in wild-type MCF-7 cells. DNA methylation is associated with chemoresistance in breast cancer and changes the characteristics of chemoresistant and chemosensitive cells. Here, we showed that the tumor-suppressor gene Notch3 was inactivated due to epigenetic silencing DNA hypermethylation in MCF-7/ADM cells...
December 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27754430/reflux-incidence-among-exclusively-breast-milk-fed-infants-differences-of-feeding-at-breast-versus-pumped-milk
#19
Jennifer Yourkavitch, Sabrina Zadrozny, Valerie L Flax
The practice of feeding infants expressed breast milk is increasing in the United States, but the impacts on infant and maternal health are still understudied. This study examines the monthly incidence of regurgitation (gastro-esophageal reflux) in exclusively breast milk fed infants from ages two to six months. Among infants whose mothers participated in the Infant Feeding Practices II Study (IFPS II; 2005-2007), data on reflux and feeding mode were collected by monthly questionnaires. A longitudinal, repeated measures analysis was used, with feeding mode lagged by one month in order to compare reflux incidence among infants fed directly at the breast to infants receiving pumped breast milk...
October 14, 2016: Children
https://www.readbyqxmd.com/read/27737436/association-of-proton-pump-inhibitors-and-capecitabine-efficacy-in-advanced-gastroesophageal-cancer-secondary-analysis-of-the-trio-013-logic-randomized-clinical-trial
#20
Michael P Chu, J Randolph Hecht, Dennis Slamon, Zev A Wainberg, Yung-Jue Bang, Paulo M Hoff, Alberto Sobrero, Shukui Qin, Karen Afenjar, Vincent Houe, Karen King, Sheryl Koski, Karen Mulder, Julie Price Hiller, Andrew Scarfe, Jennifer Spratlin, Yingjie J Huang, Saba Khan-Wasti, Neil Chua, Michael B Sawyer
Importance: Capecitabine is an oral cytotoxic chemotherapeutic commonly used across cancer subtypes. As with other oral medications though, it may suffer from drug interactions that could impair its absorption. Objective: To determine if gastric acid suppressants such as proton pump inhibitors (PPIs) may impair capecitabine efficacy. Design, Setting, and Participants: This secondary analysis of TRIO-013, a phase III randomized trial, compares capecitabine and oxaliplatin (CapeOx) with or without lapatinib in 545 patients with ERBB2/HER2-positive metastatic gastroesophageal cancer (GEC); patients were randomized 1:1 between CapeOx with or without lapatinib...
October 13, 2016: JAMA Oncology
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