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Voxel based volumetry

Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
B E Swartz, J Spitz, A L Vu, M Mandelkern, M L Su
OBJECTIVE: To investigate brain volumes in patients with well-characterized juvenile myoclonic epilepsy (JME). MATERIALS AND METHODS: We studied the MRI images of seventeen subjects with EEG and clinically defined JME and seventeen age- and sex-matched controls using voxel-based morphometry (VBM) and automated and manual volumetry. RESULTS: We found no significant group differences in the cortical volumes by automated techniques for all regions or for the whole brain...
October 2016: Acta Neurologica Scandinavica
Viola Biberacher, Paul Schmidt, Anisha Keshavan, Christine C Boucard, Ruthger Righart, Philipp Sämann, Christine Preibisch, Daniel Fröbel, Lilian Aly, Bernhard Hemmer, Claus Zimmer, Roland G Henry, Mark Mühlau
Brain volumetric measurements in multiple sclerosis (MS) reflect not only disease-specific processes but also other sources of variability. The latter has to be considered especially in multicenter and longitudinal studies. Here, we compare data generated by three different 3-Tesla magnetic resonance scanners (Philips Achieva; Siemens Verio; GE Signa MR750). We scanned two patients diagnosed with relapsing remitting MS six times per scanner within three weeks (T1w and FLAIR, 3D). We assessed T2-hyperintense lesions by an automated lesion segmentation tool and determined volumes of grey matter (GM), white matter (WM) and whole brain (GM+WM) from the lesion-filled T1-weighted images using voxel-based morphometry (SPM8/VBM8) and SIENAX (FSL)...
July 15, 2016: NeuroImage
Martin Hýža, Matyáš Kuhn, Eva Češková, Libor Ustohal, Tomáš Kašpárek
OBJECTIVES: Several lines of evidence suggest an adverse effect of psychotic episodes on brain morphology. It is not clear if this relationship reflects the cumulative effect of psychotic outbursts on the gradual progressive reduction of hippocampal tissue or an increased tendency toward psychotic episodes in patients with a smaller hippocampus at the beginning of the illness. METHODS: This is a longitudinal 4-year prospective study of patients with first-episode schizophrenia (FES, N = 58)...
September 2016: World Journal of Biological Psychiatry
Allan MacKenzie-Graham, Florian Kurth, Yuichiro Itoh, He-Jing Wang, Michael J Montag, Robert Elashoff, Rhonda R Voskuhl
IMPORTANCE: Multiple sclerosis (MS) is characterized by progressive gray matter (GM) atrophy that strongly correlates with clinical disability. However, whether localized GM atrophy correlates with specific disabilities in patients with MS remains unknown. OBJECTIVE: To understand the association between localized GM atrophy and clinical disability in a biology-driven analysis of MS. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, magnetic resonance images were acquired from 133 women with relapsing-remitting MS and analyzed using voxel-based morphometry and volumetry...
August 1, 2016: JAMA Neurology
Jeff L Waugh, John K Kuster, Jacob M Levenstein, Nikos Makris, Trisha J Multhaupt-Buell, Lewis R Sudarsky, Hans C Breiter, Nutan Sharma, Anne J Blood
BACKGROUND: Dystonia, a debilitating movement disorder characterized by abnormal fixed positions and/or twisting postures, is associated with dysfunction of motor control networks. While gross brain lesions can produce secondary dystonias, advanced neuroimaging techniques have been required to identify network abnormalities in primary dystonias. Prior neuroimaging studies have provided valuable insights into the pathophysiology of dystonia, but few directly assessed the gross volume of motor control regions, and to our knowledge, none identified abnormalities common to multiple types of idiopathic focal dystonia...
2016: PloS One
Michael Amann, Simon Pezold, Yvonne Naegelin, Ketut Fundana, Michaela Andělová, Katrin Weier, Christoph Stippich, Ludwig Kappos, Ernst-Wilhelm Radue, Philippe Cattin, Till Sprenger
Spinal cord (SC) atrophy is an important contributor to the development of disability in many neurological disorders including multiple sclerosis (MS). To assess the spinal cord atrophy in clinical trials and clinical practice, largely automated methods are needed due to the sheer amount of data. Moreover, using these methods in longitudinal trials requires them to deliver highly reliable measurements, enabling comparisons of multiple data sets of the same subject over time. We present a method for SC volumetry using 3D MRI data providing volume measurements for SC sections of fixed length and location...
July 2016: Journal of Neurology
Arturo Cardenas-Blanco, Judith Machts, Julio Acosta-Cabronero, Joern Kaufmann, Susanne Abdulla, Katja Kollewe, Susanne Petri, Stefanie Schreiber, Hans-Jochen Heinze, Reinhard Dengler, Stefan Vielhaber, Peter J Nestor
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper and lower motor neurons. Observational and intervention studies can be tracked using clinical measures such as the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) but for a complete understanding of disease progression, objective in vivo biomarkers of both central and peripheral motor pathway pathology are highly desirable. The aim of this study was to determine the utility of structural and diffusion imaging as central nervous system biomarkers compared to the standard clinical measure, ALSFRS-R, to track longitudinal evolution using three time-point measurements...
2016: NeuroImage: Clinical
R Schneider, B Bellenberg, I Kleiter, R Gold, O Köster, F Weiler, H Hahn, C Lukas
OBJECTIVES: Cervical cord involvement is common in neuromyelitis optica (NMO) and multiple sclerosis (MS), but its impact on disability in NMO has rarely been studied. Recent publications on NMO examined the periventricular system, areas of high aquaporin-4 expression, but not yet by using ventricle volumetry. PURPOSE: To compare cervical cord atrophy, ventricular widening, and supra- and infratentorial brain measures between NMO and MS, and study their impact on clinical disability...
April 21, 2016: Acta Neurologica Scandinavica
Masami Goto, Makoto Suzuki, Shinya Mizukami, Osamu Abe, Shigeki Aoki, Tosiaki Miyati, Michinari Fukuda, Tsutomu Gomi, Tohoru Takeda
PURPOSE: An understanding of the repeatability of measured results is important for both the atlas-based and voxel-based morphometry (VBM) methods of magnetic resonance (MR) brain volumetry. However, many recent studies that have investigated the repeatability of brain volume measurements have been performed using static magnetic fields of 1-4 tesla, and no study has used a low-strength static magnetic field. The aim of this study was to investigate the repeatability of measured volumes using the atlas-based method and a low-strength static magnetic field (0...
February 3, 2016: Magnetic Resonance in Medical Sciences: MRMS
Xinhu Jin, Mingtian Zhong, Shuqiao Yao, Xiyu Cao, Changlian Tan, Jun Gan, Xiongzhao Zhu, Jinyao Yi
BACKGROUND: Increasing evidence has documented subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). However, results of magnetic resonance imaging volumetry in patients with BPD are inconsistent. In addition, few researchers using voxel-based morphometry (VBM) have focused on attachment and childhood trauma in BPD. This preliminary study was performed to investigate structural brain changes and their relationships to attachment and childhood trauma in a homogenous sample of young adults with BPD...
2016: PloS One
Veronica Popescu, Menno M Schoonheim, Adriaan Versteeg, Nimisha Chaturvedi, Marianne Jonker, Renee Xavier de Menezes, Francisca Gallindo Garre, Bernard M J Uitdehaag, Frederik Barkhof, Hugo Vrenken
BACKGROUND: Studies disagree on the location of grey matter (GM) atrophy in the multiple sclerosis (MS) brain. AIM: To examine the consistency between FSL, FreeSurfer, SPM for GM atrophy measurement (for volumes, patient/control discrimination, and correlations with cognition). MATERIALS AND METHODS: 127 MS patients and 50 controls were included and cortical and deep grey matter (DGM) volumetrics were performed. Consistency of volumes was assessed with Intraclass Correlation Coefficient/ICC...
2016: PloS One
Tina Roostaei, Shokufeh Sadaghiani, Min Tae M Park, Rahil Mashhadi, Aria Nazeri, Sina Noshad, Mohammad Javad Salehi, Maryam Naghibzadeh, Abdorreza Naser Moghadasi, Mahsa Owji, Rozita Doosti, Amir Pejman Hashemi Taheri, Ali Shakouri Rad, Amirreza Azimi, M Mallar Chakravarty, Aristotle N Voineskos, Arash Nazeri, Mohammad Ali Sahraian
OBJECTIVE: To determine the motor-behavioral and neural correlates of putative functional common variants in the sodium-channel NaV1.8 encoding gene (SCN10A) in vivo in patients with multiple sclerosis (MS). METHODS: We recruited 161 patients with relapsing-onset MS and 94 demographically comparable healthy participants. All patients with MS underwent structural MRI and clinical examinations (Expanded Disability Status Scale [EDSS] and Multiple Sclerosis Functional Composite [MSFC])...
February 2, 2016: Neurology
Till Burkhardt, Daniel Lüdecke, Lothar Spies, Linus Wittmann, Manfred Westphal, Jörg Flitsch
OBJECT Cushing's disease (CD) may cause atrophy of different regions of the human brain, mostly affecting the hippocampus and the cerebellum. This study evaluates the use of 3-T MRI of newly diagnosed patients with CD to detect atrophic degeneration with voxel-based volumetry. METHODS Subjects with newly diagnosed, untreated CD were included and underwent 3-T MRI. Images were analyzed using a voxelwise statistical test to detect reduction of brain parenchyma. In addition, an atlas-based volumetric study for regions likely to be affected by CD was performed...
November 2015: Neurosurgical Focus
Anne Maass, Sandra Düzel, Tanja Brigadski, Monique Goerke, Andreas Becke, Uwe Sobieray, Katja Neumann, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Rüdiger Braun-Dullaeus, Dörte Ahrens, Hans-Jochen Heinze, Notger G Müller, Volkmar Lessmann, Michael Sendtner, Emrah Düzel
Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating exercise-induced structural and functional changes in the hippocampus. Recently, also platelet derived growth factor-C (PDGF-C) has been shown to promote blood vessel growth and neuronal survival. Moreover, reductions of these neurotrophic and angiogenic factors in old age have been related to hippocampal atrophy, decreased vascularization and cognitive decline...
May 1, 2016: NeuroImage
Yun Jeong Hong, Bora Yoon, Yong S Shim, Kook Jin Ahn, Dong Won Yang, Jae-Hong Lee
Subjective memory impairment (SMI) is now increasingly recognized as a risk factor of progression to dementia. This study investigated gray and white matter changes in the brains of SMI patients compared with normal controls and mild cognitive impairment (MCI) patients. We recruited 28 normal controls, 28 subjects with SMI, and 29 patients with MCI aged 60 or older. We analyzed gray and white matter changes using a voxel-based morphometry (VBM), hippocampal volumetry and regions of interest in diffusion tensor imaging (DTI)...
November 2015: Journal of Korean Medical Science
Stephan Cj Huijbregts, Marisa Loitfelder, Serge A Rombouts, Hanna Swaab, Berit M Verbist, Enrico B Arkink, Mark A Van Buchem, Ilya M Veer
BACKGROUND: Neurofibromatosis type 1 (NF1) is a single-gene neurodevelopmental disorder, in which social and cognitive problems are highly prevalent. Several commonly observed central nervous system (CNS) abnormalities in NF1 might underlie these social and cognitive problems. Cerebral volumetric abnormalities are among the most consistently observed CNS abnormalities in NF1. This study investigated whether differences were present between NF1 patients and healthy controls (HC) in volumetric measures of cortical and subcortical brain regions and whether differential associations existed for NF1 patients and HC between the volumetric measures and parent ratings of social skills, attention problems, social problems, autistic mannerisms, and executive dysfunction...
2015: Journal of Neurodevelopmental Disorders
Rami Homsi, Michael Meier-Schroers, Jürgen Gieseke, Darius Dabir, Julian A Luetkens, Daniel L Kuetting, Claas P Naehle, Christian Marx, Hans H Schild, Daniel K Thomas, Alois M Sprinkart
There is growing evidence that pericardial and epicardial fat volume (PFV, EFV) are associated with cardiovascular risk. We evaluated a novel method for accurate measurement of PFV and EFV using a 3D-Dixon based cardiac magnetic resonance (CMR) approach. An electrocardiography triggered and respiratory navigator gated 3D-gradient echo pulse sequence was used for cardiac Dixon imaging. Based on this sequence, voxels predominantly containing fat were identified and added up for volumetry. After accuracy assessment in phantoms, consisting of muscle tissue and seven different fat samples (50-200 ml), the sequence was acquired in 34 healthy volunteers (22 male, BMI range 14-42 kg/m(2), age range 21-79 years) at 1...
February 2016: International Journal of Cardiovascular Imaging
Anna Altbäcker, Enikő Plózer, Gergely Darnai, Gábor Perlaki, Réka Horváth, Gergely Orsi, Szilvia Anett Nagy, Péter Bogner, Attila Schwarcz, Norbert Kovács, Sámuel Komoly, Zsófia Clemens, József Janszky
Neuroimaging findings suggest that excessive Internet use shows functional and structural brain changes similar to substance addiction. Even though it is still under debate whether there are gender differences in case of problematic use, previous studies by-passed this question by focusing on males only or by using gender matched approach without controlling for potential gender effects. We designed our study to find out whether there are structural correlates in the brain reward system of problematic Internet use in habitual Internet user females...
September 23, 2015: Brain Imaging and Behavior
Ji Sun Kim, Jin-Ju Yang, Dong-Kyun Lee, Jong-Min Lee, Jinyoung Youn, Jin Whan Cho
BACKGROUND/AIMS: Previous studies indicate that patients with the parkinsonian subtype of multiple system atrophy (MSA-P) experience cognitive impairment. This study aimed to identify the existence of cognitive impairments and the different topographic patterns of morphological changes in MSA-P by means of imaging analysis, and also whether these morphological changes could be associated with cognitive dysfunctions in MSA-P. METHODS: We recruited 15 nondemented probable MSA-P patients and 32 normal controls (NC) for neuropsychological testing and MRI...
2015: Neuro-degenerative Diseases
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