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Voxel based volumetry

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https://www.readbyqxmd.com/read/28941760/bilateral-cingulum-fiber-reductions-in-temporal-lobe-epilepsy-with-unilateral-hippocampal-sclerosis
#1
H Urbach, K Egger, K Rutkowski, J M Nakagawa, B Schmeiser, M Reisert, A Brandt, B J Steinhoff, A Schulze-Bonhage, T Hammen
PURPOSE: To evaluate whether white matter tracts within the Papez circuit are altered in patients with unilateral hippocampal sclerosis (HS). METHODS: Twenty patients with histologically proven unilateral HS and 20 age-matched controls were studied with a 3T Epilepsy-dedicated MRI protocol including a MPRAGE sequence for hippocampus volumetry and a diffusion tensor imaging (DTI) sequence (61 diffusion-encoding directions, 2×2×2mm(3) voxels) for diffusion tensor tractography (DTT)...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28792656/amygdala-and-regional-volumes-in-treatment-resistant-versus-nontreatment-resistant-depression-patients
#2
Anca-Larisa Sandu, Eric Artiges, André Galinowski, Thierry Gallarda, Frank Bellivier, Hervé Lemaitre, Bernard Granger, Damien Ringuenet, Eleni T Tzavara, Jean-Luc Martinot, Marie-Laure Paillère Martinot
BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented. METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls...
August 9, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28699215/automated-t2-relaxometry-of-the-hippocampus-for-temporal-lobe-epilepsy
#3
Gavin P Winston, Sjoerd B Vos, Jane L Burdett, M Jorge Cardoso, Sebastien Ourselin, John S Duncan
OBJECTIVE: Hippocampal sclerosis (HS), the most common cause of refractory temporal lobe epilepsy, is associated with hippocampal volume loss and increased T2 signal. These can be identified on quantitative imaging with hippocampal volumetry and T2 relaxometry. Although hippocampal segmentation for volumetry has been automated, T2 relaxometry currently involves subjective and time-consuming manual delineation of regions of interest. In this work, we develop and validate an automated technique for hippocampal T2 relaxometry...
September 2017: Epilepsia
https://www.readbyqxmd.com/read/28408290/automated-template-based-brain-localization-and-extraction-for-fetal-brain-mri-reconstruction
#4
Sébastien Tourbier, Clemente Velasco-Annis, Vahid Taimouri, Patric Hagmann, Reto Meuli, Simon K Warfield, Meritxell Bach Cuadra, Ali Gholipour
Most fetal brain MRI reconstruction algorithms rely only on brain tissue-relevant voxels of low-resolution (LR) images to enhance the quality of inter-slice motion correction and image reconstruction. Consequently the fetal brain needs to be localized and extracted as a first step, which is usually a laborious and time consuming manual or semi-automatic task. We have proposed in this work to use age-matched template images as prior knowledge to automatize brain localization and extraction. This has been achieved through a novel automatic brain localization and extraction method based on robust template-to-slice block matching and deformable slice-to-template registration...
July 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28374074/abnormal-subcortical-nuclei-shapes-in-patients-with-type-2-diabetes-mellitus
#5
Ji Chen, Junxiang Zhang, Xuebing Liu, Xiaoyang Wang, Xiangjin Xu, Hui Li, Bo Cao, Yanqiu Yang, Jingjing Lu, Ziqian Chen
OBJECTIVES: Type 2 diabetes mellitus (T2DM) increases the risk of brain atrophy and dementia. We aimed to elucidate deep grey matter (GM) structural abnormalities and their relationships with T2DM cognitive deficits by combining region of interest (ROI)-based volumetry, voxel-based morphometry (VBM) and shape analysis. METHODS: We recruited 23 T2DM patients and 24 age-matched healthy controls to undergo T1-weighted structural MRI scanning. Images were analysed using the three aforementioned methods to obtain deep GM structural shapes and volumes...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28057431/advanced-structural-neuroimaging-in-progressive-supranuclear-palsy-where-do-we-stand
#6
REVIEW
Albert Stezin, Abhishek Lenka, Ketan Jhunjhunwala, Jitender Saini, Pramod K Pal
Progressive supranuclear palsy (PSP) is a progressive neurological disorder characterized by presence of supranuclear gaze palsy, early postural instability, parkinsonism and cognitive impairment. Advanced structural neuroimaging studies have demonstrated variable areas of grey and white matter involvement in PSP. Grey matter (GM) involvement is predominantly reported in the midbrain, subcortical structures such as thalamus and basal ganglia, and cerebellum. Most white matter (WM) tracts are also reported to be damaged in PSP...
March 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28047588/su-f-i-20-volumetric-reduction-of-the-corpus-callosum-in-alzheimer-s-disease-and-mild-cognitive-impairment
#7
R Juh, T Suh, J Han, C Kim, C Oh
PURPOSE: This study investigated correlations between regional corpus callosum (CC) atrophy and cognitive measurements in AD subjects at mild disease stages with volumetry. Our aims were to replicate ROI-based findings of reduced volumes of the CC in mild cognitive impairment (MCI) patients relative to AD and to investigate, on a voxel-by-voxel basis, the presence of significant correlations between CC atrophy and cognitive test scores in AD subjects. METHODS: We used the VBM and cross-sectional ROI-based volumetry approach to conduct a detailed assessment of CC volumetric reductions in a probable AD patient (n=40) in comparison to MCI (n=40) and Subjective memory impairment (SMI) (n=12) matched for age...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#8
MULTICENTER STUDY
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
January 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/27836833/the-whole-brain-pattern-of-magnetic-susceptibility-perturbations-in-parkinson-s-disease
#9
Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Matthew J Betts, Michaela Butryn, Jose P Valdes-Herrera, Imke Galazky, Peter J Nestor
Although iron-mediated oxidative stress has been proposed as a potential pathomechanism in Parkinson's disease, the global distribution of iron accumulation in Parkinson's disease has not yet been elucidated. This study used a new magnetic resonance imaging contrast, quantitative susceptibility mapping, and state-of-the-art methods to map for the first time the whole-brain landscape of magnetostatic alterations as a surrogate for iron level changes in n = 25 patients with idiopathic Parkinson's disease versus n = 50 matched controls...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27734300/early-effects-of-a-high-caloric-diet-and-physical-exercise-on-brain-volumetry-and-behavior-a-combined-mri-and-histology-study-in-mice
#10
Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27592844/heterogeneity-of-anatomic-regions-by-mr-volumetry-in-juvenile-myoclonic-epilepsy
#11
B E Swartz, J Spitz, A L Vu, M Mandelkern, M L Su
OBJECTIVE: To investigate brain volumes in patients with well-characterized juvenile myoclonic epilepsy (JME). MATERIALS AND METHODS: We studied the MRI images of seventeen subjects with EEG and clinically defined JME and seventeen age- and sex-matched controls using voxel-based morphometry (VBM) and automated and manual volumetry. RESULTS: We found no significant group differences in the cortical volumes by automated techniques for all regions or for the whole brain...
October 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27431758/intra-and-interscanner-variability-of-magnetic-resonance-imaging-based-volumetry-in-multiple-sclerosis
#12
Viola Biberacher, Paul Schmidt, Anisha Keshavan, Christine C Boucard, Ruthger Righart, Philipp Sämann, Christine Preibisch, Daniel Fröbel, Lilian Aly, Bernhard Hemmer, Claus Zimmer, Roland G Henry, Mark Mühlau
Brain volumetric measurements in multiple sclerosis (MS) reflect not only disease-specific processes but also other sources of variability. The latter has to be considered especially in multicenter and longitudinal studies. Here, we compare data generated by three different 3-Tesla magnetic resonance scanners (Philips Achieva; Siemens Verio; GE Signa MR750). We scanned two patients diagnosed with relapsing remitting MS six times per scanner within three weeks (T1w and FLAIR, 3D). We assessed T2-hyperintense lesions by an automated lesion segmentation tool and determined volumes of grey matter (GM), white matter (WM) and whole brain (GM+WM) from the lesion-filled T1-weighted images using voxel-based morphometry (SPM8/VBM8) and SIENAX (FSL)...
November 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/27403591/hippocampal-volume-in-first-episode-schizophrenia-and-longitudinal-course-of-the-illness
#13
Martin Hýža, Matyáš Kuhn, Eva Češková, Libor Ustohal, Tomáš Kašpárek
OBJECTIVES: Several lines of evidence suggest an adverse effect of psychotic episodes on brain morphology. It is not clear if this relationship reflects the cumulative effect of psychotic outbursts on the gradual progressive reduction of hippocampal tissue or an increased tendency toward psychotic episodes in patients with a smaller hippocampus at the beginning of the illness. METHODS: This is a longitudinal 4-year prospective study of patients with first-episode schizophrenia (FES, N = 58)...
September 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27294295/disability-specific-atlases-of-gray-matter-loss-in-relapsing-remitting-multiple-sclerosis
#14
Allan MacKenzie-Graham, Florian Kurth, Yuichiro Itoh, He-Jing Wang, Michael J Montag, Robert Elashoff, Rhonda R Voskuhl
IMPORTANCE: Multiple sclerosis (MS) is characterized by progressive gray matter (GM) atrophy that strongly correlates with clinical disability. However, whether localized GM atrophy correlates with specific disabilities in patients with MS remains unknown. OBJECTIVE: To understand the association between localized GM atrophy and clinical disability in a biology-driven analysis of MS. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, magnetic resonance images were acquired from 133 women with relapsing-remitting MS and analyzed using voxel-based morphometry and volumetry...
August 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27171035/thalamic-volume-is-reduced-in-cervical-and-laryngeal-dystonias
#15
Jeff L Waugh, John K Kuster, Jacob M Levenstein, Nikos Makris, Trisha J Multhaupt-Buell, Lewis R Sudarsky, Hans C Breiter, Nutan Sharma, Anne J Blood
BACKGROUND: Dystonia, a debilitating movement disorder characterized by abnormal fixed positions and/or twisting postures, is associated with dysfunction of motor control networks. While gross brain lesions can produce secondary dystonias, advanced neuroimaging techniques have been required to identify network abnormalities in primary dystonias. Prior neuroimaging studies have provided valuable insights into the pathophysiology of dystonia, but few directly assessed the gross volume of motor control regions, and to our knowledge, none identified abnormalities common to multiple types of idiopathic focal dystonia...
2016: PloS One
https://www.readbyqxmd.com/read/27159989/reliable-volumetry-of-the-cervical-spinal-cord-in-ms-patient-follow-up-data-with-cord-image-analyzer-cordial
#16
Michael Amann, Simon Pezold, Yvonne Naegelin, Ketut Fundana, Michaela Andělová, Katrin Weier, Christoph Stippich, Ludwig Kappos, Ernst-Wilhelm Radue, Philippe Cattin, Till Sprenger
Spinal cord (SC) atrophy is an important contributor to the development of disability in many neurological disorders including multiple sclerosis (MS). To assess the spinal cord atrophy in clinical trials and clinical practice, largely automated methods are needed due to the sheer amount of data. Moreover, using these methods in longitudinal trials requires them to deliver highly reliable measurements, enabling comparisons of multiple data sets of the same subject over time. We present a method for SC volumetry using 3D MRI data providing volume measurements for SC sections of fixed length and location...
July 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27104135/structural-and-diffusion-imaging-versus-clinical-assessment-to-monitor-amyotrophic-lateral-sclerosis
#17
Arturo Cardenas-Blanco, Judith Machts, Julio Acosta-Cabronero, Joern Kaufmann, Susanne Abdulla, Katja Kollewe, Susanne Petri, Stefanie Schreiber, Hans-Jochen Heinze, Reinhard Dengler, Stefan Vielhaber, Peter J Nestor
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper and lower motor neurons. Observational and intervention studies can be tracked using clinical measures such as the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) but for a complete understanding of disease progression, objective in vivo biomarkers of both central and peripheral motor pathway pathology are highly desirable. The aim of this study was to determine the utility of structural and diffusion imaging as central nervous system biomarkers compared to the standard clinical measure, ALSFRS-R, to track longitudinal evolution using three time-point measurements...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27098675/cervical-cord-and-ventricle-affection-in-neuromyelitis-optica
#18
COMPARATIVE STUDY
R Schneider, B Bellenberg, I Kleiter, R Gold, O Köster, F Weiler, H Hahn, C Lukas
OBJECTIVES: Cervical cord involvement is common in neuromyelitis optica (NMO) and multiple sclerosis (MS), but its impact on disability in NMO has rarely been studied. Recent publications on NMO examined the periventricular system, areas of high aquaporin-4 expression, but not yet by using ventricle volumetry. PURPOSE: To compare cervical cord atrophy, ventricular widening, and supra- and infratentorial brain measures between NMO and MS, and study their impact on clinical disability...
March 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/26841856/repeatability-of-brain-volume-measurements-made-with-the-atlas-based-method-from-t1-weighted-images-acquired-using-a-0-4-tesla-low-field-mr-scanner
#19
Masami Goto, Makoto Suzuki, Shinya Mizukami, Osamu Abe, Shigeki Aoki, Tosiaki Miyati, Michinari Fukuda, Tsutomu Gomi, Tohoru Takeda
PURPOSE: An understanding of the repeatability of measured results is important for both the atlas-based and voxel-based morphometry (VBM) methods of magnetic resonance (MR) brain volumetry. However, many recent studies that have investigated the repeatability of brain volume measurements have been performed using static magnetic fields of 1-4 tesla, and no study has used a low-strength static magnetic field. The aim of this study was to investigate the repeatability of measured volumes using the atlas-based method and a low-strength static magnetic field (0...
October 11, 2016: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/26808504/a-voxel-based-morphometric-mri-study-in-young-adults-with-borderline-personality-disorder
#20
Xinhu Jin, Mingtian Zhong, Shuqiao Yao, Xiyu Cao, Changlian Tan, Jun Gan, Xiongzhao Zhu, Jinyao Yi
BACKGROUND: Increasing evidence has documented subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). However, results of magnetic resonance imaging volumetry in patients with BPD are inconsistent. In addition, few researchers using voxel-based morphometry (VBM) have focused on attachment and childhood trauma in BPD. This preliminary study was performed to investigate structural brain changes and their relationships to attachment and childhood trauma in a homogenous sample of young adults with BPD...
2016: PloS One
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