keyword
MENU ▼
Read by QxMD icon Read
search

atherosis

keyword
https://www.readbyqxmd.com/read/27859887/preclinical-atherosclerosis-at-the-time-of-pre-eclamptic-pregnancy-and-up-to-10-years-postpartum-systematic-review-and-meta-analysis
#1
REVIEW
Natasa M Milic, Jelena Milin-Lazovic, Tracey L Weissgerber, Goran Trajkovic, Wendy M White, Vesna D Garovic
OBJECTIVES: Preeclampsia, a pregnancy-specific hypertensive disorder, has been associated with cardiovascular risk factors and vascular changes, such as acute atherosis in placental blood vessels, which are similar to early-stage atherosclerosis. The objective of this study was to determine whether women with preeclampsia have increased atherosclerotic burden, as determined by carotid intima-media thickness (CIMT), when compared to women without preeclampsia. METHODS: We conducted a systematic review and meta-analysis of studies that reported CIMT, a non-invasive, ultrasound-based measure of subclinical atherosclerosis, in women who did vs...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27801754/intratumoral-vasculopathy-in-leiomyoma-treated-with-tranexamic-acid
#2
Satoru Kudose, Hannah R Krigman
Although intravascular thrombi and infarct-type necrosis have been reported in leiomyomas following with tranexamic acid therapy, intratumoral vasculopathy resembling acute atherosis has not been reported to date in patients without exposure to gonadotropin receptor agonist. We describe a case of intratumoral vasculopathy resembling acute atherosis in a leiomyoma in a 49-year-old woman, with hereditary hemorrhagic telangiectasia and menorrhagia, treated with tranexamic acid. The patient had no exposure to gonadotropin receptor agonists...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27624400/preeclampsia-with-and-without-intrauterine-growth-restriction-two-pathogenetically-different-entities
#3
Jelena Milosevic-Stevanovic, Miljan Krstic, Dragana Radovic-Janosevic, Milan Stefanovic, Vladimir Antic, Ivana Djordjevic
OBJECTIVE: The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS: A prospective case-control study included a study group consisting of 30 pregnant women with preeclampsia completed by cesarean section (CS), in 19 of whom preeclampsia was associated with IUGR, and in 11 it was not. The control group consisted of 20 healthy pregnant women delivered by elective CS...
September 13, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27219485/spiral-artery-remodeling-and-maternal-cardiovascular-risk-the-spiral-artery-remodeling-spar-study
#4
Jan H W Veerbeek, Laura Brouwers, Maria P H Koster, Steven V Koenen, Elvira O G van Vliet, Peter G J Nikkels, Arie Franx, Bas B van Rijn
BACKGROUND: Women with a history of placental bed disorders, including preeclampsia and intrauterine growth restriction have an increased long-term risk of cardiovascular disease (CVD). Further, similarities exist between atherosclerosis and abnormalities observed in placental bed spiral arteries in pregnancies affected by preeclampsia and intrauterine growth restriction, such as acute atherosis and defective remodeling. This suggests a common pathophysiological pathway underlying both disorders...
August 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26718026/anticancer-effect-of-xanthohumol-induces-growth-inhibition-and-apoptosis-of-human-liver-cancer-through-nf-%C3%AE%C2%BAb-p53-apoptosis-signaling-pathway
#5
Xiangqian Zhao, Kai Jiang, Bin Liang, Xiaoqiang Huang
Xanthohumol may prevent and cure diabetes and atherosis, have oxidation resistance and antiviral function as well as anticancer effect preventing cancer cell metastasis. We investigate whether the anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-κB/p53-apoptosis signaling pathway. Human liver cancer HepG2 cell were treated with 10, 20, 30 and 40 µM xanthohumol for 48 h. The present study showed that the anticancer effect of xanthohumol was effective in inhibiting proliferation and inducing apoptosis of human liver cancer HepG2 cells...
February 2016: Oncology Reports
https://www.readbyqxmd.com/read/26608629/acute-atherosis-in-vacuum-suction-biopsies-of-decidua-basalis-an-evidence-based-research-definition
#6
Patji Alnaes-Katjavivi, Fiona Lyall, Borghild Roald, Christopher W G Redman, Anne Cathrine Staff
BACKGROUND: Acute atherosis (AA) of the uteroplacental spiral arteries has been characterised by subendothelial lipid-laden foam cells, perivascular leukocyte infiltrates (PVI) and fibrinoid necrosis. Because precise diagnostic criteria are not available for comparative research studies we developed and tested new simplified criteria based on 237 cases. METHODS: Decidual basalis samples were collected by vacuum suction at elective cesarean deliveries. Spiral arteries were evaluated in serial decidual tissue sections from women with normal pregnancy, preeclampsia, and diabetes...
January 2016: Placenta
https://www.readbyqxmd.com/read/26569622/decrease-in-sphingomyelin-d18-1-16-0-in-stem-villi-and-phosphatidylcholine-16-0-20-4-in-terminal-villi-of-human-term-placentas-with-pathohistological-maternal-malperfusion
#7
Kaori Yamazaki, Noritaka Masaki, Yukiko Kohmura-Kobayashi, Chizuko Yaguchi, Takahiro Hayasaka, Hiroaki Itoh, Mitsutoshi Setou, Naohiro Kanayama
Placental villi play pivotal roles in feto-maternal transportation and phospholipids constitute a major part of the villous membrane. We have been developing and optimizing an imaging system based on a matrix-assisted laser desorption/ionization (MALDI)-based mass spectrometer, which provides clear two-dimensional molecular distribution patterns using highly sensitive mass spectrometry from mixtures of ions generated on tissue surfaces. We recently applied this technology to normal human uncomplicated term placentas and detected the specific distribution of sphingomyelin (SM) (d18:1/16:0) in stem villi and phosphatidylcholine (PC) (16:0/20:4) in terminal villi...
2015: PloS One
https://www.readbyqxmd.com/read/26530045/acute-atherosis-of-the-uterine-spiral-arteries-clinicopathologic-implications
#8
REVIEW
Joo-Yeon Kim, Yeon Mee Kim
Acute atherosis is unique vascular changes of the placenta associated with poor placentation. It is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis of the arterial wall, perivascular lymphocytic infiltration, and it is histologically similar to early-stage atherosclerosis. Acute atherosis is rare in normal pregnancies, but is frequently observed in non- transformed spiral arteries in abnormal pregnancies, such as preeclampsia, small for gestational age (SGA), fetal death, spontaneous preterm labor and preterm premature rupture of membranes...
November 2015: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/26527498/a-suggestion-about-the-cause-of-inflammation-in-acute-atherosis-complicating-poor-placentation-in-preeclampsia
#9
Arnold E Eggers
The hypothesis is set forth that maternal release of epinephrine in the adrenal medulla causes systemic platelet activation (SPA) which, in turn, initiates coagulation via the intrinsic pathway and leads to thrombin generation. Thrombin causes inflammation, which is the underlying cause of acute atherosis in preeclampsia (PE). Each step of this cascade is examined in detail and supporting literature documented. SPA is associated with migraine headaches, which are a prominent clinical feature of PE and may help explain why PE is a risk factor for future maternal cardiovascular disease...
December 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26104649/the-six-stages-of-pre-eclampsia
#10
Cwg Redman
For many years pre eclampsia has been considered to be a two-stage disease. The first stage comprises poor placentation. The second stage is the clinical expression of the disease namely new hypertension and new proteinuria. The first stage is preclinical and symptomless, which evolves between weeks 8 and 18 of pregnancy, when the uteroplacental circulation is established by spiral artery remodelling. Its consequence is dysfunctional perfusion of the intervillous space of the placenta with oxidative and haemodynamic stress...
July 2014: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25917671/kalrn-rare-and-common-variants-and-susceptibility-to-ischemic-stroke-in-chinese-han-population
#11
COMPARATIVE STUDY
Meizheng Dang, Zhenzhen Wang, Ruyou Zhang, Xiaoying Li, Yanqing Peng, Xuesong Han, Litao Sun, Jiawei Tian
Stroke is the second most common cause of mortality worldwide, and it is a major cause of physical disability. Several genome-wide association studies have yielded numerous common variants which increase the risk of ischemic stroke, including the Kalirin-coding gene, KALRN. KALRN strongly associates with early-onset coronary artery disease and atherosclerosis and plays an important role in stroke in the European population. In this study, we analyzed four KALRN gene SNPs in 503 ischemic stroke patients and 493 control subjects, separating the patients into separate research groups based on comorbidity with hypertension or diabetes and stroke type (atherosis or lacunar and combination type)...
September 2015: Neuromolecular Medicine
https://www.readbyqxmd.com/read/25911290/chronic-villitis-of-unknown-etiology-and-massive-chronic-intervillositis-have-similar-immune-cell-composition
#12
C A Labarrere, J W Hardin, D M Haas, G S Kassab
INTRODUCTION: Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic characteristics. METHODS: A cross-sectional study of third trimester placentas was conducted to identify immune cell subpopulations in CVUE and MCI (n = 17/group)...
June 2015: Placenta
https://www.readbyqxmd.com/read/25889304/anti-inflammatory-and-morphologic-effects-of-pitavastatin-on-carotid-arteries-and-thoracic-aorta-evaluated-by-integrated-backscatter-trans-esophageal-ultrasound-and-pet-ct-a-prospective-randomized-comparative-study-with-pravastatin-epicentre-study
#13
RANDOMIZED CONTROLLED TRIAL
Takatomo Watanabe, Masanori Kawasaki, Ryuhei Tanaka, Koji Ono, Nobuo Kako, Maki Saeki, Noriyuki Onishi, Maki Nagaya, Noriaki Sato, Hirotaka Miwa, Masazumi Arai, Toshiyuki Noda, Sachiro Watanabe, Shinya Minatoguchi
BACKGROUND: We sought to evaluate the effects of a strong lipophilic statin (pitavastatin) on plaque components and morphology assessed by transesophageal echocardiography (TEE) and transthoracic echocardiography (TTE), as well as plaque inflammation assessed by 18F-fluorodeoxyglucose (FDG) PET/CT in the thoracic aorta and the carotid artery. Furthermore, we compared the effects of pitavastatin with those of mild hydrophilic statin (pravastatin). METHODS: We examined atherosclerotic plaques in the thoracic aorta by TEE and those in the carotid artery by integrated backscatter (IBS)-TTE and PET/CT...
April 2, 2015: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/25760902/pathology-of-endometrial-ablation-failures-a-clinicopathologic-study-of-164-cases
#14
Rochelle A Simon, M Ruhul Quddus, W Dwayne Lawrence, C James Sung
Endometrial ablation is a minimally invasive alternative to hysterectomy for abnormal uterine bleeding. Although the failure rate is low, continued bleeding or development of pelvic pain after ablation does occur. We analyzed the clinicopathologic features of 164 hysterectomy specimens after endometrial ablation, 19 of which were performed for indications other than failed ablation (control cases). Pathologic findings included: dense fibrosis and hyalinization of the endometrial surface ablative necrosis within the uterine cavity and adherent to the endometrial surface, persistent months after ablation; uterine cavity lined by superficial, large, congested, patent blood vessels with atherosis; ablation changes present only in the lower uterine segment; and residual endometrium present in the cornual regions...
May 2015: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25308204/the-frequency-of-acute-atherosis-in-normal-pregnancy-and-preterm-labor-preeclampsia-small-for-gestational-age-fetal-death-and-midtrimester-spontaneous-abortion
#15
Yeon Mee Kim, Piya Chaemsaithong, Roberto Romero, Majid Shaman, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M Jacques, Ahmed I Ahmed, Tinnakorn Chaiworapongsa, Sonia S Hassan, Lami Yeo, Steven J Korzeniewski
OBJECTIVE: Acute atherosis is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis and perivascular lymphocytic infiltration. This lesion is generally confined to non-transformed spiral arteries and is frequently observed in patients with preeclampsia. However, the frequency of acute atherosis in the great obstetrical syndromes is unknown. The purpose of this study was to determine the frequency and topographic distribution of acute atherosis in placentas and placental bed biopsy samples obtained from women with normal pregnancy and those affected by the "great obstetrical syndromes"...
2015: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25183023/placental-lesions-associated-with-acute-atherosis
#16
Yeon Mee Kim, Piya Chaemsaithong, Roberto Romero, Majid Shaman, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M Jacques, Ahmed I Ahmed, Tinnakorn Chaiworapongsa, Sonia S Hassan, Lami Yeo, Steven J Korzeniewski
OBJECTIVE: Acute atherosis is a lesion of the spiral arteries characterized by fibrinoid necrosis of the vessel wall, an accumulation of fat-containing macrophages, and a mononuclear perivascular infiltrate, which can be found in patients with preeclampsia, fetal death, small-for-gestational age, spontaneous preterm labor/premature prelabor rupture of membrane, and spontaneous mid-trimester abortion. This lesion is thought to decrease blood flow to the intervillous space which may lead to other vascular lesions of the placenta...
September 2015: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25062083/placental-lesions-of-vascular-insufficiency-are-associated-with-anti-angiogenic-state-in-women-with-preeclampsia
#17
Kedak Baltajian, Jonathan L Hecht, Julia B Wenger, Saira Salahuddin, Stefan Verlohren, Frank H Perschel, Zsuzsanna K Zsengeller, Ravi Thadhani, S Ananth Karumanchi, Sarosh Rana
OBJECTIVE: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. MATERIALS AND METHODS: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio ≥85 and normal angiogenic preeclampsia with sFlt1/PlGF < 85...
November 2014: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/24906549/placental-pathologic-changes-of-maternal-vascular-underperfusion-in-bronchopulmonary-dysplasia-and-pulmonary-hypertension
#18
K K Mestan, J Check, L Minturn, S Yallapragada, K N Farrow, X Liu, E Su, N Porta, N Gotteiner, L M Ernst
INTRODUCTION: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of infancy, and BPD-associated pulmonary hypertension (PH) is a serious complication that can negatively impact later childhood health. There is growing evidence that lung injury leading to BPD and PH is due to chronic fetal hypoxia-ischemia. The purpose of this study was to investigate whether placental pathologic changes of maternal vascular underperfusion (MVU) are associated with BPD, and further increased with PH...
August 2014: Placenta
https://www.readbyqxmd.com/read/24625285/histologic-differences-in-placentas-of-preeclamptic-eclamptic-gestations-by-birthweight-placental-weight-and-time-of-onset
#19
Matthew W Stark, Latoya Clark, Randall D Craver
With preeclampsia/eclampsia (PE/E), infants more often are either large or small for gestational age. We explored whether the differences in infant birthweight (BW), placental weights (PW), or time of onset are associated with histologic features of maternal vascular underperfusion. A retrospective chart identified 243 PE/E gestations between 2007 and 2010. Gestational age only was known at slide review. Investigated features included increased syncytial knots, villous agglutination, increased intervillous fibrin, distal villous hypoplasia, acute atherosis, mural hypertrophy of membrane arterioles, muscularized basal plate arteries, increased placental site giant cells, increased immature intermediate trophoblasts, infarcts, and villitis...
May 2014: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/24411701/ifpa-award-in-placentology-lecture-preeclampsia-the-decidual-battleground-and-future-maternal-cardiovascular-disease
#20
A C Staff, C W G Redman
The decidua basalis is one of the frontiers between placenta and mother. Its spiral arteries ensure that the placenta and fetus have adequate access to the maternal circulation, without compromising maternal health. Normally this requires a tightly regulated collaboration between tissues of genetically different individuals. But like all frontiers it can become a battlefield. The decidua is difficult to sample systematically. Some of the problems have been resolved by our vacuum suction method. We review the technique and how it has contributed to what we know of decidual tissue, especially when it becomes a battlefield in preeclampsia, with its increased oxidative stress and inflammation...
February 2014: Placenta
keyword
keyword
100643
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"