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Diabetes transition

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https://www.readbyqxmd.com/read/28212301/the-phytocomplex-from-fucus-vesiculosus-and-ascophyllum-nodosum-controls-postprandial-plasma-glucose-levels-an-in-vitro-and-in-vivo-study-in-a-mouse-model-of-nash
#1
Daniela Gabbia, Stefano Dall'Acqua, Iole Maria Di Gangi, Sara Bogialli, Valentina Caputi, Laura Albertoni, Ilaria Marsilio, Nicola Paccagnella, Maria Carrara, Maria Cecilia Giron, Sara De Martin
Edible seaweeds have been consumed by Asian coastal communities since ancient times. Fucus vesiculosus and Ascophyllum nodosum extracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM)...
February 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28196555/dohad-at-the-intersection-of-maternal-immune-activation-and-maternal-metabolic-stress-a-scoping-review
#2
J A Goldstein, S A Norris, D M Aronoff
The prenatal environment is now recognized as a key driver of non-communicable disease risk later in life. Within the developmental origins of health and disease (DOHaD) paradigm, studies are increasingly identifying links between maternal morbidity during pregnancy and disease later in life for offspring. Nutrient restriction, metabolic disorders during gestation, such as diabetes or obesity, and maternal immune activation provoked by infection have been linked to adverse health outcomes for offspring later in life...
February 15, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28192030/medical-care-expenditures-for-individuals-with-prediabetes-the-potential-cost-savings-in-reducing-the-risk-of-developing-diabetes
#3
Tamkeen Khan, Stavros Tsipas, Gregory Wozniak
The United States has 86 million adults with prediabetes. Individuals with prediabetes can prevent or delay the development of type 2 diabetes through lifestyle modifications such as participation in the National Diabetes Prevention Program (DPP), thereby mitigating the medical and economic burdens associated with diabetes. A cohort analysis of a commercially insured population was conducted using individual-level claims data from Truven Health MarketScan(®) Lab Database to identify adults with prediabetes, track whether they develop diabetes, and compare medical expenditures for those who are newly diagnosed with diabetes to those who are not...
February 13, 2017: Population Health Management
https://www.readbyqxmd.com/read/28191472/suppression-of-excessive-histone-deacetylases-activity-in-diabetic-hearts-attenuates-myocardial-ischemia-reperfusion-injury-via-mitochondria-apoptosis-pathway
#4
Yang Wu, Yan Leng, Qingtao Meng, Rui Xue, Bo Zhao, Liying Zhan, Zhongyuan Xia
Background. Histone deacetylases (HDACs) play a pivotal role in signaling modification and gene transcriptional regulation that are essential for cardiovascular pathophysiology. Diabetic hearts with higher HDACs activity were more vulnerable to myocardial ischemia/reperfusion (MI/R) injury compared with nondiabetic hearts. We are curious about whether suppression of excessive HDACs activity in diabetic heart protects against MI/R injury. Methods. Diabetic rats were subjected to 45 min of ischemia, followed by 3 h of reperfusion...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28185153/role-of-the-gut-on-glucose-homeostasis-lesson-learned-from-metabolic-surgery
#5
REVIEW
V Kamvissi-Lorenz, M Raffaelli, S Bornstein, G Mingrone
PURPOSE OF REVIEW: Bariatric surgery was initially intended to reduce weight, and only subsequently was the remission of type two diabetes (T2D) observed as a collateral event. At the moment, the term "metabolic surgery" is used to underline the fact that this type of surgery is performed specifically to treat diabetes and its metabolic complications, such as hyperlipidemia. RECENT FINDINGS: Randomized, controlled studies have recently supported the use of bariatric surgery, and in particular of Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion (BPD) as an effective treatment for decompensated T2D...
February 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28181342/mrna-destabilization-improves-glycemic-responsiveness-of-transcriptionally-regulated-hepatic-insulin-gene-therapy-in-vitro-and-in-vivo
#6
Peter M Thulé, Yulin Lin, Dingwu Jia, Darin E Olson, Shiue-Cheng Tang, Athanassios Sambanis
BACKGROUND: Hepatic insulin gene therapy (HIGT) employing a glucose and insulin sensitive promoter to direct insulin transcription can lower blood sugars within 2 hours of an intra-peritoneal glucose challenge. However, post-challenge blood sugars frequently decline to below baseline. We hypothesize that this "over-shoot" hypoglycemia results from sustained translation of long-lived transgene message, and that reducing pro-insulin message half-life will ameliorate post-challenge hypoglycemia...
February 8, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28179696/effects-of-oral-vanadium-on-glycaemic-and-lipid-profile-in-rats
#7
Syed Zubair Hussain Shah, Abdul Khaliq Naveed, Amir Rashid
OBJECTIVE: Vanadyl sulphate, an inorganic tetravalent salt of transition metal vanadium is conventionally used to treat diabetes and by athletes as body-building supplement. Vanadyl sulphate is a constituent of many supplements and herbal preparations available over the counter in many parts of the world. In this study the efficacy of the salt as hypoglycaemic agent and its effects on lipid profile were determined when administered in therapeutic dose range (in humans) to healthy Sprague Dawley rats for a considerable duration...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28177738/sorbitol-increases-muscle-glucose-uptake-ex-vivo-and-inhibits-intestinal-glucose-absorption-ex-vivo-and-in-normal-and-type-2-diabetic-rats
#8
Chika I Chukwuma, Md Shahidul Islam
Previous studies have suggested that sorbitol, a known polyol sweetener possesses glycemic control potentials. However, the effect of sorbitol on intestinal glucose absorption and muscle glucose uptake still remains elusive. The present study investigated the effects of sorbitol on intestinal glucose absorption and muscle glucose uptake as possible anti-hyperglycemic or glycemic control potentials using <i>ex vivo </i>and in vivo experimental models. Sorbitol (2.5% to 20%) inhibited glucose absorption in isolated rat jejuna (IC<sub>50</sub> = 14...
December 12, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177592/predictors-of-type-1-diabetes-mellitus-outcomes-in-young-adults-after-transition-from-pediatric-care
#9
Alassaf Abeer, Gharaibeh Lubna, Grant Christina, Punthakee Zubin
BACKGROUND: Type 1 diabetes is a common chronic disease. Poor health outcomes are often noted after transfer to adult health care. It is important to determine the predictors of such outcomes to decrease the morbidity and mortality. METHODS: This retrospective study included patients followed ≥1year pre-transfer and ≥1 year post-transfer to adult care in a Canadian tertiary diabetes center. Data including demographics, education, comorbidity and pediatric diabetes management-related factors were analyzed as possible independent predictors of adult HbA1c, number of adult diabetes-related hospitalization and clinic visits...
February 8, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28176508/a-structured-therapeutic-education-program-for-children-and-adolescents-with-type-1-diabetes-an-analysis-of-the-efficacy-of-the-pediatric-education-for-diabetes-project
#10
Alessandra Mauri, Susanna Schmidt, Valentina Sosero, Maria Sambataro, Laura Nollino, Francesco Fabris, Anna Corò, Antonella Scantamburlo, Michela Cazziola-Merlotto, Tania Ciani, Michele Tessarin, Agostino Paccagnella
BACKGROUND: Therapeutic education for Type 1 Diabetes involves the process of transmitting knowledge and developing the skills and behavior required to treat the disease. guidelines agree on stressing the importance of therapeutic educational intervention in teaching self-management skills to children and adolescents with Type 1 Diabetes (T1D). This study presents the results of the "Pediatric Education for Type 1 Diabetes (T1D)" (PED) project, specifically designed for children and adolescents aged 6 to 16, and structured on guidelines indications, as part of a broader clinical-educational intervention for Type 1 diabetes...
February 7, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28166726/endothelial-colony-forming-cells-ecfcs-in-murine-aki-implications-for-future-cell-based-therapies
#11
D Patschan, K Schwarze, B Tampe, M Zeisberg, S Patschan, G A Müller
BACKGROUND: In recent years, early Endothelial Progenitor Cells (eEPCs) have been proven as effective tool in murine ischemic AKI and in diabetic nephropathy. The mechanisms of eEPC-mediated vasoprotection have been elucidated in detail. Besides producing a diverse range of humoral factors, the cells also act by secreting vasomodulatory microvesicles. Only few data in contrast have been published about the role of so-called Endothelial Colony Forming Cells (ECFCs - late EPCs) in ischemic AKI...
February 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28166324/effect-of-intensive-blood-pressure-control-on-gait-speed-and-mobility-limitation-in-adults-75-years-or-older-a-randomized-clinical-trial
#12
Michelle C Odden, Carmen A Peralta, Dan R Berlowitz, Karen C Johnson, Jeffrey Whittle, Dalane W Kitzman, Srinivasan Beddhu, John W Nord, Vasilios Papademetriou, Jeff D Williamson, Nicholas M Pajewski
Importance: Intensive blood pressure (BP) control confers a benefit on cardiovascular morbidity and mortality; whether it affects physical function outcomes is unknown. Objective: To examine the effect of intensive BP control on changes in gait speed and mobility status. Design, Setting, and Participants: This randomized, clinical trial included 2636 individuals 75 years or older with hypertension and no history of type 2 diabetes or stroke who participated in the Systolic Blood Pressure Intervention Trial (SPRINT)...
February 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28164326/developmentally-regulated-alternative-splicing-is-perturbed-in-type-1-diabetic-skeletal-muscle
#13
Curtis A Nutter, Elizabeth Jaworski, Sunil K Verma, Yareli Perez-Carrasco, Muge N Kuyumcu-Martinez
INTRODUCTION: Type 1 diabetic patients can develop skeletal muscle weakness and atrophy by molecular mechanisms that are not well understood. Alternative splicing (AS) is critical for gene expression in the skeletal muscle and its dysregulation is implicated in muscle weakness and atrophy. Therefore, we investigated if AS patterns are affected in Type 1 diabetic skeletal muscle contributing to skeletal muscle defects. METHODS: AS patterns were determined by RT-PCR and levels of RNA binding proteins were assessed by Western blot in Type 1 diabetic mouse skeletal muscle and during normal mouse skeletal muscle development...
February 6, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28163747/tangzhiqing-granules-alleviate-podocyte-epithelial-mesenchymal-transition-in-kidney-of-diabetic-rats
#14
Haiyan Xu, Xu Wang, Mingming Liu, Xueyuan He
This study discussed the effect of Tangzhiqing granules on podocyte epithelial-mesenchymal transition in kidney of diabetic rats. The diabetic rats were divided randomly into five groups: DM group treated with vehicle, Tangzhiqing granules low-dose treatment group, Tangzhiqing granules middle-dose treatment group, and Tangzhiqing granules high-dose treatment group. Eight Wistar rats used as control group were given saline solution. The intervention was all intragastric administration for 8 weeks. At the end of the 8 weeks, biochemical parameters and kidney weight/body weight ratio were measured...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28163084/research-needs-for-effective-transition-in-lifelong-care-of-congenital-genitourinary-conditions-a-workshop-sponsored-by-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases
#15
REVIEW
Michael H Hsieh, Hadley M Wood, Brad E Dicianno, Nienke P Dosa, Veronica Gomez-Lobo, Tej K Mattoo, Rosalia Misseri, Jenna M Norton, Kathleen J Sawin, Peter Scal, James E Wright, Robert A Star, Tamara Bavendam
Over the last 5 decades, health-care advances have yielded quantum improvements in the life expectancy of individuals with congenital genitourinary conditions (CGCs), leading to a crisis of care. Many individuals with CGC enter adulthood unprepared to manage their condition. Pediatric CGC specialists lack training to manage adulthood-related health-care issues, whereas adult genitourinary specialists lack training within the context of CGCs. To address these challenges, the National Institutes of Diabetes and Digestive and Kidney Diseases convened individuals with CGCs and experts from a variety of fields to identify research needs to improve transitional urology care...
February 2, 2017: Urology
https://www.readbyqxmd.com/read/28159531/a-validated-lc-ms-ms-method-for-the-estimation-of-glimepiride-and-pitavastatin-in-rat-plasma-application-to-drug-interaction-studies
#16
Shruti Surendran, David Paul, Ratna Sushmita, Lavanya Krishna, Nirbhay Kumar Tiwari, Sanjeev Giri, Nanjappan Satheeshkumar
Glimepiride (GLI) is prescribed for the management of type-2 diabetes where as pitavastatin (PIT) for the treatment of diabetes associated dyslipidemia. Both the drugs are metabolized by CYP2C9 and have the potential of altering the enzyme through either inhibition or induction. In this respect, we present a simple, fast and validated bioanalytical LC-MS/MS method for the simultaneous estimation of GLI and PIT from rat plasma. Waters XTerra RP HPLC column (4.6×100mm, 5μm) with mobile phase consisting of acetonitrile and 10mM ammonium acetate (pH-6...
January 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28153000/effectiveness-of-the-cardiac-diabetes-transcare-program-protocol-for-a-randomised-controlled-trial
#17
Chiung-Jung Jo Wu, John J Atherton, Richard J MacIsaac, Mary Courtney, Anne M Chang, David R Thompson, Karam Kostner, Andrew I MacIsaac, Michael d'Emden, Nick Graves, Steven M McPhail
BACKGROUND: This paper presents a protocol for a randomised controlled trial of the Cardiac-Diabetes Transcare program which is a transitional care, multi-modal self-management program for patients with acute coronary syndrome comorbid with type 2 diabetes. Prior research has indicated people hospitalised with dual cardiac and diabetes diagnoses are at an elevated risk of hospital readmissions, morbidity and mortality. The primary aim of this study is to evaluate the effectiveness (and cost-effectiveness) of a Cardiac-Diabetes Transcare intervention program on 6-month readmission rate in comparison to usual care...
February 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28149314/transition-in-public-knowledge-of-risk-factors-of-cardiovascular-disease-in-an-iranian-general-population-a-latent-transition-analysis-lta-on-a-longitudinal-large-community-based-educational-prevention-program
#18
Mahsa Rafiee Alhossaini, Akbar Hassanzadeh, Awat Feizi, Nizal Sarrafzadegan
BACKGROUND: Cardiovascular diseases (CVD) are the second leading cause of death, after accidents, in Iran. This study was performed to assess the change in levels of knowledge about 8 risk factors of CVD and its associated determinants the Iranian general population. METHODS: The current repeated cross-sectional study included 3014 people in 2004, 3012 in 2005, and 4719 in 2007, aged older than 19 years. Knowledge about 8 risk factors (high blood pressure, nutrition, physical inactivity, smoking, diabetes, heredity, stress, and obesity) as the major causes of CVD was evaluated using latent transition analysis (LTA)...
July 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28149017/malabsorption-orocecal-transit-time-and-small-intestinal-bacterial-overgrowth-in-type-2-diabetic-patients-a-connection
#19
S V Rana, Aastha Malik, Sanjay K Bhadada, Naresh Sachdeva, Rajesh Kumar Morya, Gaurav Sharma
Type 2 diabetes mellitus consists of dysfunctions characterized by hyperglycemia and resulting from combination of resistance to insulin action and inadequate insulin secretion. Most of diabetic patients report significant gastrointestinal symptoms. Entire GI tract can be affected by diabetes from oral cavity to large bowel and anorectal region. Proteins, carbohydrates, fats, and most fluids are absorbed in small intestine. Malabsorption may occurs when proper absorption of nutrients does not take place due to bacterial overgrowth or altered gut motility...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28146141/type-1-diabetes-from-adolescence-to-adulthood-is-there-a-permanent-need-for-nutrition-education-and-reeducation
#20
Maja Baretić, Martina Matovinović Osvatić, Eva Pavić, Nada Rabađija, Valentina Uroić, Carolina Koletić, Nataša Rojnić Putarek, Ivana Pavlić Renar
BACKGROUND: The transition for type 1 diabetes patients from paediatric to adult diabetology care is challenging process for both medical team and patients. Adult diabetology usually insists on stricter goals and focuses on increased empowerment and self-care. We set to find a more practical and effective way to determine patient knowledge and skills during the transition. The aim of the study was to identify screening questions which best represent knowledge in management of type 1 diabetes and to explore the differences in the effect of a structured educational program for type 1 diabetes patient diagnosed in childhood versus adulthood...
January 31, 2017: Minerva Endocrinologica
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