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Diabetes transition

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https://www.readbyqxmd.com/read/29340756/differential-effect-of-a-patient-education-transition-intervention-in-adolescents-with-ibd-vs-diabetes
#1
Silke Schmidt, Henriette Markwart, Franziska Bomba, Holger Muehlan, Annette Findeisen, Martina Kohl, Ingo Menrath, Ute Thyen
Patient education programs (PEPs) to improve disease management are part of standard and regular treatment in adolescents with diabetes. In Germany, youth with inflammatory bowel disease (IBD) receive individual counseling but not PEPs in group settings. Generic PEPs have been developed in order to improve transition from child-centered to adolescent health services. The aim of the study was to investigate the effects of a transition-oriented PEP on quality of life (QoL) and self-management in young patients with IBD (PEP naive), compared to patients with diabetes (familiar with PEPs)...
January 16, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29337718/physical-inactivity-from-youth-to-adulthood-and-risk-of-impaired-glucose-metabolism
#2
Petri Kallio, Katja Pahkala, Olli J Heinonen, Tuija Tammelin, Mirja Hirvensalo, Risto Telama, Markus Juonala, Costan G Magnussen, Suvi Rovio, Harri Helajärvi, Nina Hutri-Kähönen, Jorma Viikari, Olli T Raitakari
INTRODUCTION: Physical activity (PA) is important in the prevention and treatment of impaired glucose metabolism. However, association of physical inactivity during the transition between childhood and adulthood with glucose metabolism is unknown. Therefore, we studied the association of persistent physical inactivity since childhood with glucose metabolism in adulthood. METHODS: Data were drawn from the ongoing, Cardiovascular Risk in Young Finns Study with repeated follow-ups between 1980-2011 (baseline age 3-18 years, n=3596)...
January 15, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29335249/hypertension-and-diabetes-mellitus-coprediction-and-time-trajectories
#3
Vasilis Tsimihodimos, Clicerio Gonzalez-Villalpando, James B Meigs, Ele Ferrannini
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of diabetes mellitus is characterized by a relatively rapid increase in plasma glucose values. Whether a similar phenomenon occurs during the development of hypertension is not known. We analyzed the pattern of blood pressure (BP) changes during the development of hypertension in patients with or without diabetes mellitus using data from the MCDS (Mexico City Diabetes Study; a population-based study of diabetes mellitus in Hispanic whites) and in the FOS (Framingham Offspring Study, a community-based study in non-Hispanic whites) during a 7-year follow-up...
January 15, 2018: Hypertension
https://www.readbyqxmd.com/read/29331655/what-makes-it-so-difficult-for-nurses-to-coach-patients-in-shared-decision-making-a-process-evaluation
#4
Stephanie Anna Lenzen, Ramon Daniëls, Marloes Amantia van Bokhoven, Trudy van der Weijden, Anna Beurskens
BACKGROUND: Primary care nurses play a crucial role in coaching patients in shared decision making about goals and actions. This presents a challenge to practice nurses, who are frequently used to protocol-based working routines. Therefore, an approach was developed to support nurses to coach patients in shared decision making. OBJECTIVES: To investigate how the approach was implemented and experienced by practice nurses and patients. DESIGN: A process evaluation was conducted using quantitative and qualitative methods...
December 16, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29331414/inhibition-of-fasn-and-er%C3%AE-signalling-during-hyperglycaemia-induced-matrix-specific-emt-promotes-breast-cancer-cell-invasion-via-a-caveolin-1-dependent-mechanism
#5
H A Zielinska, J M P Holly, A Bahl, C M Perks
Since disturbed metabolic conditions such as obesity and diabetes can be critical determinants of breast cancer progression and therapeutic failure, we aimed to determine the mechanism responsible for their pro-oncogenic effects. Using non-invasive, epithelial-like ERα-positive MCF-7 and T47D human breast cancer cells we found that hyperglycaemia induced epithelial to mesenchymal transition (EMT), a key programme responsible for the development of metastatic disease. This was demonstrated by loss of the epithelial marker E-cadherin together with increases in mesenchymal markers such as vimentin, fibronectin and the transcription factor SLUG, together with an enhancement of cell growth and invasion...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29327131/renal-vein-thrombosis-complicating-severe-acute-pyelonephritis-with-renal-abscesses-and-associated-bacteraemia-caused-by-extended-spectrum-beta-lactamase-producing-escherichia-coli
#6
Stelios F Assimakopoulos, Pantelis Kraniotis, Charalambos Gogos, Markos Marangos
Acute pyelonephritis might be complicated by the formation of renal and perirenal abscesses and very rarely by renal vein thrombosis, which is a life-threatening condition. The main causative agents of acute pyelonephritis are enterobacteriaceae with the incidence of extended-spectrum beta-lactamase (ESBL)-producing strains increasing worldwide. We present the case of a 71-year-old Greek man with history of diabetes mellitus and recent hospitalization, who suffered from severe pyelonephritis with renal abscesses formation and associated bacteraemia caused by ESBL-producing Escherichia coli, complicated by extensive thrombosis of the ipsilateral renal vein and its branches, protruding also in the inferior venal cava...
January 11, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29324755/hiv-1-co-receptor-tropism-and-liver-fibrosis-in-hiv-infected-patients
#7
Annalisa Saracino, Alessandro Cozzi-Lepri, Milensu Shanyinde, Francesca Ceccherini Silberstein, Silvia Nozza, Antonio Di Biagio, Giovanni Cassola, Giuseppe Bruno, Maria Capobianchi, Massimo Puoti, Laura Monno, Antonella d'Arminio Monforte
BACKGROUND: In vitro, gp120 of both X4 and R5 HIV-1 strains activates human hepatic stellate cells, but if it can promote liver fibrosis in vivo is unknown. We aimed to evaluate if patients carrying X4 or R5 strains have a different liver fibrosis (LF) progression over time. METHODS: A total of 1,137 HIV-infected patients in ICONA cohort (21% females, 7% HCV co-infected) with an available determination of HIV-1 co-receptor tropism (CRT), a Fibrosis-4 Index for Liver Fibrosis (FIB-4) <3...
2018: PloS One
https://www.readbyqxmd.com/read/29303370/the-effects-of-subcutaneous-insulin-infusion-versus-multiple-insulin-injections-on-glucose-variability-in-young-adults-with-type-1-diabetes-the-2-year-follow-up-of-the-observational-metro-study
#8
Maria Ida Maiorino, Giuseppe Bellastella, Ofelia Casciano, Paolo Cirillo, Vittorio Simeon, Paolo Chiodini, Michela Petrizzo, Maurizio Gicchino, Ornella Romano, Paola Caruso, Dario Giugliano, Katherine Esposito
BACKGROUND: Type 1 diabetic patients have high instability of daily glucose levels. The aim of this study was to evaluate the long-term effects of continuous subcutaneous insulin infusion (CSII) therapy, compared with multiple daily injections of insulin (MDI), on glucose variability, in young type 1 diabetic patients transitioned to the adult diabetes care. METHODS: Patients aged 18-30 years and considered eligible for insulin pump therapy were included in the study...
January 5, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29302537/morbidity-pattern-and-its-relation-to-functional-limitations-among-old-age-rural-population-in-kerala-india
#9
R Anil Das, S Ganesh Kumar, Gautam Roy
Background: In the present era of demographic transition, morbidity pattern among geriatric population and its relation to functional limitations is an important health issue in developing countries. Objective: The objective of this study was to assess the reported morbidities and its relation to functional limitations among rural geriatric population. Materials and Methods: A community-based cross-sectional study was carried out among 167 old age participants aged ≥60 years to assess morbidities and its relation to functional limitations in a rural area of Kerala, India...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29299678/diabetes-and-number-of-years-of-life-lost-with-and-without-cardiovascular-disease-a-multi-state-homogeneous-semi-markov-model
#10
Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh, Amir Abbas Momenan
AIMS: We quantified the impact of type 2 diabetes on incidence of non-fatal cardiovascular disease (CVD) and mortality, considering CVD as a continuum from occurrence of diabetes to the end point, and estimated the 15-year life expectancy with and without CVD. METHODS: A total of 7239 Iranian adults (3246 men), aged ≥ 30 years, were followed from 1999 to 2014. We applied a multi-state semi-Markov model with three transitions including CVD-free to non-fatal CVD, CVD-free to death and non-fatal CVD to death, and studied the influence of diabetes on each transition rate, stratifying by sex and adjusting for confounders...
January 3, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29296567/carthami-flos-regulates-gastrointestinal-motility-functions
#11
Iksung Kim, Jinsoo Bae, Byung Joo Kim
Background: Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility. Methods: We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin. Results: Both ITRs and gastric emptying were increased by CF (0.0025-0...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29295829/medication-therapy-management-after-hospitalization-in-ckd-a-randomized-clinical-trial
#12
Katherine R Tuttle, Radica Z Alicic, Robert A Short, Joshua J Neumiller, Brian J Gates, Kenn B Daratha, Celestina Barbosa-Leiker, Sterling M McPherson, Naomi S Chaytor, Brad P Dieter, Stephen M Setter, Cynthia F Corbett
BACKGROUND AND OBJECTIVES: CKD is characterized by remarkably high hospitalization and readmission rates. Our study aim was to test a medication therapy management intervention to reduce subsequent acute care utilization. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The CKD Medication Intervention Trial was a single-blind (investigators), randomized clinical trial conducted at Providence Health Care in Spokane, Washington. Patients with CKD stages 3-5 not treated by dialysis who were hospitalized for acute illness were recruited...
January 2, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29295576/intracellular-renin-inhibits-mitochondrial-permeability-transition-pore-via-activated-mitochondrial-extracellular-signal-regulated-kinase-erk-1-2-during-ischemia-in-diabetic-hearts
#13
Terumori Satoh, Masao Saotome, Hideki Katoh, Daishi Nonaka, Prottoy Hasan, Hideharu Hayashi, Yuichiro Maekawa
Although beneficial effects of non-secreting intracellular renin (ns-renin) against ischemia have been reported, the precise mechanism remains unclear. In this study, we investigated the roles of ns-renin and mitochondrial extracellular signal-related kinase (ERK) 1/2 on mitochondrial permeability transition pore (mPTP) opening during ischemia in diabetes mellitus (DM) hearts. When isolated hearts from Wistar rats (non-DM hearts) and Goto-Kakizaki rats (DM hearts) were subjected to ischemia for 70 min by left anterior descending coronary artery ligation, DM hearts exhibited higher left ventricular (LV) developed pressure and lower LV end-diastolic pressure than non-DM hearts, suggesting ischemic resistance...
December 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29290941/eucalyptol-ameliorates-snail1-%C3%AE-catenin-dependent-diabetic-disjunction-of-renal-tubular-epithelial-cells-and-tubulointerstitial-fibrosis
#14
Dong Yeon Kim, Min-Kyung Kang, Sin-Hye Park, Eun-Jung Lee, Yun-Ho Kim, Hyeongjoo Oh, Yean-Jung Choi, Young-Hee Kang
Renal tubulointerstitial fibrosis is an important event in the pathogenesis of diabetic nephropathy. Under pathologic conditions, renal tubular epithelial cells undergo transition characterized by loss of cell-cell adhesion and increased cell migration. This study investigated that eucalyptol inhibited tubular epithelial cell disjunction and tubulointerstitial fibrosis stimulated by glucose. Human renal proximal tubular epithelial cells were incubated for up to 72 h in media containing 27.5 mM mannitol as osmotic controls or 33 mM glucose in the presence of 1-20 μM eucalyptol...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289437/ampk-and-friends-central-regulators-of-%C3%AE-cell-biology
#15
REVIEW
Jillian L Rourke, Queenie Hu, Robert A Screaton
If left unchecked, prediabetic hyperglycemia can progress to diabetes and often life-threatening attendant secondary complications. Central to the process of glucose homeostasis are pancreatic β cells, which sense elevations in plasma glucose and additional dietary components and respond by releasing the appropriate quantity of insulin, ensuring the arrest of hepatic glucose output and glucose uptake in peripheral tissues. Given that β cell failure is associated with the transition from prediabetes to diabetes, improved β cell function ('compensation') has a central role in preventing type 2 diabetes mellitus (T2DM)...
December 27, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29287106/life-expectancy-with-and-without-cognitive-impairment-by-diabetes-status-among-older-americans
#16
Carlos Díaz-Venegas, Daniel C Schneider, Mikko Myrskylä, Neil K Mehta
Diabetes affects mortality and cognitive functioning. It is not known how diabetes influences life expectancy (LE) with and without cognitive impairment. We seek to examine age at onset of cognitive impairment and life expectancy (LE) with and without cognitive impairment by diabetes status among middle- and older-aged Americans. Data come from the U.S. Health and Retirement Study 2000-2012 linked to the National Death Index (N = 13,687). We use multinomial regression models stratified by gender and controlling for age, education and race/ethnicity to estimate diabetes-status specific transition probabilities, then use a Markov chain matrix population model to calculate age at onset of cognitive impairment and LE with and without cognitive impairment by diabetes status at age 50...
2017: PloS One
https://www.readbyqxmd.com/read/29286194/antidiarrheal-effect-of-sodium-hydrosulfide-in-diabetic-rats-in-vitro-and-in-vivo-studies
#17
M Saghazadeh-Dezfuli, H Fanaei, M K Gharib-Naseri, S Nasri, S A Mard
BACKGROUND: The inhibitory effects of H2 S on spontaneous contractions of smooth muscles of small, and large intestines well-established but its role in the pathophysiology of diarrhea has not been identified. Therefore, this study evaluated the role of exogenous H2 S (NaHS) on diabetic-induced diarrhea and determined mRNA expression of cystathionine β-lyase (CSE) and cystathionine γ-synthase (CBS) in diabetic rats. METHODS: In order to evaluate antidiarrheal effect of H2 S, normal and diabetic rats received NaHS and L-Cysteine and the total number of fecal pellets (FP) determined...
December 29, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29284718/cohort-profile-study-of-transition-outcomes-and-gender-strong-to-assess-health-status-of-transgender-people
#18
Virginia P Quinn, Rebecca Nash, Enid Hunkeler, Richard Contreras, Lee Cromwell, Tracy A Becerra-Culqui, Darios Getahun, Shawn Giammattei, Timothy L Lash, Andrea Millman, Brandi Robinson, Douglas Roblin, Michael J Silverberg, Jennifer Slovis, Vin Tangpricha, Dennis Tolsma, Cadence Valentine, Kevin Ward, Savannah Winter, Michael Goodman
PURPOSE: The Study of Transition, Outcomes and Gender (STRONG) was initiated to assess the health status of transgender people in general and following gender-affirming treatments at Kaiser Permanente health plans in Georgia, Northern California and Southern California. The objectives of this communication are to describe methods of cohort ascertainment and data collection and to characterise the study population. PARTICIPANTS: A stepwise methodology involving computerised searches of electronic medical records and free-text validation of eligibility and gender identity was used to identify a cohort of 6456 members with first evidence of transgender status (index date) between 2006 and 2014...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29284155/a-retrospective-analysis-comparing-oral-stepdown-therapy-for-enterobacteriaceae-bloodstream-infections-fluoroquinolones-versus-beta-lactams
#19
Nicholas J Mercuro, Patricia Stogsdill, Minkey Wungwattana
Enterobacteriaceae bloodstream infections (EB-BSI) are a common manifestation of Gram-negative sepsis, and are initially managed with empiric intravenous (IV) antibiotics. Upon stabilization and source control, patients are often transitioned to an oral agent. The fluoroquinolone (FQ) class plays a prominent role in stepdown therapy for severe infections due to favorable pharmacokinetic parameters; however, serious adverse effects have been documented with their use. Two hundred and twenty-four adults with EB-BSI initiated on empiric IV antibiotics with stepdown to oral beta-lactam (BLM) (n= 84) or FQ (n= 140) were included to compare clinical success and identify risk factors for treatment failure...
December 25, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29279000/oxygen-uptake-on-kinetics-during-six-minute-walk-test-predicts-short-term-outcomes-after-off-pump-coronary-artery-bypass-surgery
#20
Isadora Salvador Rocco, Marcela Viceconte, Hayanne Osiro Pauletti, Bruna Caroline Matos-Garcia, Natasha Oliveira Marcondi, Caroline Bublitz, Douglas William Bolzan, Rita Simone Lopes Moreira, Michel Silva Reis, Nelson Américo Hossne, Walter José Gomes, Ross Arena, Solange Guizilini
PURPOSE: We aimed to investigate the ability of oxygen uptake kinetics to predict short-term outcomes after off-pump coronary artery bypass grafting. METHODS: Fifty-two patients aged 60.9 ± 7.8 years waiting for off-pump coronary artery bypass surgery were evaluated. The 6-min walk test distance was performed pre-operatively, while simultaneously using a portable cardiopulmonary testing device. The transition of oxygen uptake kinetics from rest to exercise was recorded to calculate oxygen uptake kinetics fitting a monoexponential regression model...
December 26, 2017: Disability and Rehabilitation
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