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https://www.readbyqxmd.com/read/28326205/shigella-sonnei-bacteremia-presenting-with-profound-hepatic-dysfunction
#1
Oluwaseun Shogbesan, Andrew Rettew, Bilal Shaikh, Abdullateef Abdulkareem, Anthony Donato
Worldwide, Shigellosis is a significant public health issue, associated with nearly one million deaths annually. About half a million cases of Shigella infection are reported annually in the United States. Shigella bacteremia is uncommon and generally seen in children and immunocompromised adults. We present a case of a Shigella sonnei bacteremia with marked hepatic derangement in a 27-year-old previously healthy homosexual male with history of Roux-en-Y gastric bypass, who presented to the emergency room with a 4-day history of loose watery stool, abdominal cramps, nausea and vomiting, and yellow skin of 2-day duration...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28320203/dietary-pectic-oligosaccharide-administration-improves-the-growth-performance-and-immunity-in-weaned-pigs-infected-by-rotavirus
#2
Hao Chen, Haiyan Hu, Daiwen Chen, Jun Tang, Bing Yu, Junqiu Luo, Jun He, Yuheng Luo, Jie Yu, Xiangbing Mao
Rotavirus infection is one of the main pathogenic causes of gastroenteritis and diarrhea in children and young animals. The present study aimed to determine whether dietary pectic oligosaccharide (POS) supplementation could improve the growth performance and immunity in weaned pigs infected by porcine rotavirus (PRV). Twenty-eight crossbred weaned galts were randomly divided into two groups fed with basal diet with or without POS for 18 d. On 15th day, the PRV were orally infused to half of the pigs. ADFI, ADG and F/G ratio were impaired by PRV infection in weaned pigs (P < 0...
March 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28315028/potential-for-screening-for-pancreatic-exocrine-insufficiency-using-the-fecal-elastase-1-test
#3
REVIEW
J Enrique Domínguez-Muñoz, Philip D Hardt, Markus M Lerch, Matthias J Löhr
The early diagnosis of pancreatic exocrine insufficiency (PEI) is hindered because many of the functional diagnostic techniques used are expensive and require specialized facilities, which prevent their widespread availability. We have reviewed current evidence in order to compare the utility of these functional diagnostic techniques with the fecal elastase-1 (FE-1) test in the following three scenarios: screening for PEI in patients presenting with symptoms suggestive of pancreatic disease, such as abdominal pain or diarrhea; determining the presence of PEI in patients with an established diagnosis of pancreatic disease, such as chronic pancreatitis or cystic fibrosis; determining exocrine status in disorders not commonly tested for PEI, but which have a known association with this disorder...
March 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28288854/irinotecan-induced-bile-acid-malabsorption-is-associated-with-down-regulation-of-ileal-asbt-slc10a2-in-mice
#4
A-Xi Shi, Yan Zhou, Xiao-Yi Zhang, Yan-Shu Zhao, Hong-Yan Qin, Yan-Ping Wang, Xin-An Wu
Irinotecan, (CPT-11), an antitumor agent primarily used for the treatment of solid tumors, has often compromised clinical application due to the inducement of severe delay-onset diarrhea. Bile acid malabsorption (BAM) is widely accepted as the common cause of diarrhea. However, whether CPT-11-induced diarrhea has correlation with BAM is unknown. The aim of this study was to investigate the effect of CPT-11 on the bile acid homeostasis in mice. The mice were administrated with CPT-11 intravenously for four consecutive days...
March 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28288591/correlates-of-thymus-size-and-changes-during-treatment-of-children-with-severe-acute-malnutrition-a-cohort-study
#5
Maren Johanne Heilskov Rytter, Hanifa Namusoke, Christian Ritz, Kim F Michaelsen, André Briend, Henrik Friis, Dorthe Jeppesen
BACKGROUND: The impairment of immune functions associated with malnutrition may be one reason for the high mortality in children with severe acute malnutrition (SAM), and thymus atrophy has been proposed as a marker of this immunodeficiency. The aim of this study was to identify nutritional and clinical correlates of thymus size in children with SAM, and predictors of change in thymus size with nutritional rehabilitation. METHODS: In an observational study among children aged 6-59 months admitted with SAM in Uganda, we measured thymus area by ultrasound on hospital admission to treatment with F75 and F100, on hospital discharge and after 8 weeks of nutritional rehabilitation with ready-to-use therapeutic food, as well as in well-nourished healthy children...
March 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28286114/mechanism-of-deoxynivalenol-effects-on-the-reproductive-system-and-fetus-malformation-current-status-and-future-challenges
#6
REVIEW
Miao Yu, Liangkai Chen, Zhao Peng, Andreas K Nüssler, Qinghua Wu, Liegang Liu, Wei Yang
Deoxynivalenol (DON) is a toxic fungal secondary metabolite produced by molds of the Fusarium genus, and it is known to cause a spectrum of diseases both in humans and animals, such as emesis, diarrhea, anorexia, immunotoxicity, hematological disorders, impairment of maternal reproduction, and fetal development. The recently revealed teratogenic potential of DON has received much attention. In various animal models, it has been shown that DON led to skeletal deformities of the fetus. However, the underlying mechanisms are not yet fully understood, and toxicological data are also scarce...
March 7, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28282296/herbal-and-dietary-supplements-related-to-diarrhea-and-acute-kidney-injury-a-case-report
#7
Suphamat Wanitsriphinyo, Mayuree Tangkiatkumjai
Background There is very little evidence relating to the association of herbal medicine with diarrhea and the development of acute kidney injury (AKI). This study reports a case of diarrhea-induced AKI, possibly related to an individual ingesting copious amounts of homemade mixed fruit and herb puree. Case presentation A 45-year-old Thai man with diabetes had diarrhea for 2 days, as a result of taking high amounts of a puree made up of eight mixed fruits and herbs over a 3-day period. He developed dehydration and stage 2 AKI, with a doubling of his serum creatinine...
March 1, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28281162/the-effect-of-porcine-epidemic-diarrhea-ped-on-ovarian-function-and-reproductive-performance-after-weaning-in-berkshire-sows
#8
Yosuke Sasaki, Tadahiro Kawabata, Michiko Noguchi
The purpose of this study was to investigate the ovarian condition at weaning and subsequent reproductive performance of Berkshire sows following an outbreak of PED. This study was conducted on a farrow-to-finish farm that experienced a PED outbreak beginning on January 6, 2014. Blood samples were collected at weaning from 19 to 20 sows every month from July 2013 until July 2014 to investigate the ovarian condition. The mean progesterone concentration was numerically higher during January 2014 than the other months, but this difference was not significant...
March 10, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28277870/safety-and-effectiveness-of-tadalafil-in-patients-with-pulmonary-arterial-hypertension-japan-post-marketing-surveillance-data
#9
Hiroyoshi Yamazaki, Noriko Kobayashi, Masanori Taketsuna, Koyuki Tajima, Masahiro Murakami
OBJECTIVE: To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS: This prospective, multicenter, noninterventional, post-marketing surveillance included patients with PAH who were observed for up to 2 years after initiation of tadalafil. Safety was assessed by analyzing the frequency of adverse drug reactions (ADRs), discontinuations due to adverse events (AEs), and serious adverse drug reactions (SADRs)...
February 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28277856/electrical-therapies-for-gastrointestinal-motility-disorders
#10
Jiande D Z Chen, Jieyun Yin, Wei Wei
Gastrointestinal (GI) motility disorders are common in clinical settings, including esophageal motility disorders, gastroesophageal reflux disease, functional dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction, post-operative ileus, irritable bowel syndrome, diarrhea and constipation. While a number of drugs have been developed for treating GI motility disorders, few are currently available. Emerging electrical stimulation methods may provide new treatment options for these GI motility disorders...
March 6, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28276853/worsening-of-rest-activity-circadian-rhythm-and-quality-of-life-in-female-breast-cancer-patients-along-progression-of-chemotherapy-cycles
#11
Armiya Sultan, Vivek Choudhary, Arti Parganiha
Chemotherapy and its associated side effects can induce the disruption of circadian rest-activity rhythm and may have negative consequences on health-related quality of life (HRQoL) of cancer patients. In the current study, repeated-measures cross-sectional design was implemented to determine the status of circadian rest-activity rhythm and to assess the HRQoL of newly diagnosed female breast cancer patients those were planned to receive six cycles of chemotherapy. Rest activity and HRQoL were assessed in twenty-five patients during chemotherapy cycles 1st (C1), 3rd (C3), and 6th (C6) immediately after they reported to the outdoor ward of the Regional Cancer Center, Pt...
February 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28275187/tight-junction-protein-occludin-is-a-porcine-epidemic-diarrhea-virus-entry-factor
#12
Xiaolei Luo, Longjun Guo, Jian Zhang, Yunfei Xu, Weihong Gu, Li Feng, Yue Wang
Porcine epidemic diarrhea virus (PEDV), the causative agent of porcine epidemic diarrhea, has caused huge economic losses in pig-producing countries. Although it was long believed to replicate in the intestinal epithelium using aminopeptidase N as a receptor, the mechanisms of PEDV infection are not fully characterized. In this study, we found that PEDV infection of epithelial cells resulted in the disruption of the tight junctional distribution of occludin to the intracellular localization. Overexpression of occludin in target cells makes them more susceptible for PEDV infection, whereas ablation of occludin expression using siRNA in target cells significantly reduces their susceptibility to virus infection...
March 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28275113/potential-mechanisms-of-effects-of-serum-derived-bovine-immunoglobulin-protein-isolate-therapy-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome
#13
Nelson Valentin, Michael Camilleri, Paula Carlson, Sean C Harrington, Deborah Eckert, Jessica O'Neill, Duane Burton, Jun Chen, Audrey L Shaw, Andres Acosta
Serum-derived bovine immunoglobulin/protein isolate (SBI), an oral nutritional therapy, is efficacious in diverse diarrheal diseases. In an open-label study in 15 patients with irritable bowel syndrome-diarrhea (IBS-D), we evaluated effects of SBI (5.0 g, twice a day) for 8 weeks on safety, on bowel function and abdominal pain, tryptophan metabolism (K:T ratio), intestinal permeability ((13)C-mannitol and lactulose excretion), bile acid synthesis (fasting serum FGF-19 and C4), duodenal and stool microbiome, and the expression of 90 genes related to inflammation, immune function, and tight junctions in duodenal mucosa...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28274109/what-is-new-in-rome-iv
#14
REVIEW
Max J Schmulson, Douglas Arnold Drossman
Functional gastrointestinal disorders (FGIDs) are diagnosed and classified using the Rome criteria; the criteria may change over time as new scientific data emerge. The Rome IV was released in May 2016. The aim is to review the main changes in Rome IV. FGIDs are now called disorders of gut-brain interaction (DGBI). Rome IV has a multicultural rather than a Western-culture focus. There are new chapters including multicultural, age-gender-women's health, intestinal microenvironment, biopsychosocial, and centrally mediated disorders...
March 9, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28274108/small-intestinal-bacterial-overgrowth-and-irritable-bowel-syndrome-a-bridge-between-functional-organic-dichotomy
#15
REVIEW
Uday C Ghoshal, Ratnakar Shukla, Ujjala Ghoshal
The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is the realization that gut dysbiosis, including small intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78% of patients with IBS and 1% and 40% of controls have SIBO; such wide variations in prevalence might result from population differences, IBS diagnostic criteria, and, most importantly, methods to diagnose SIBO...
March 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28273275/assessing-the-sleep-quality-and-depression-anxiety-stress-in-irritable-bowel-syndrome-patients
#16
Nadieh Baniasadi, Mohammad Moein Dehesh, Elham Mohebbi, Mahdy Hayatbakhsh Abbasi, Zohreh Oghabian
BACKGROUND: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders with chronic abdominal pain and altered bowel habit without any organic reason. Sleep disorders may be associated to IBS. OBJECTIVE: We aimed to assess sleep disturbances and depression-anxiety-stress in IBS patients. METHODS: In this analytical cross sectional study from November 2013 to May 2014, A total of 123 IBS patients were recruited by simple random sampling...
February 23, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28273273/prevalence-of-small-intestine-bacterial-overgrowth-in-patients-with-gastrointestinal-symptoms
#17
Carolina Piedade Martins, Caio Henrique Amorim Chaves, Maurício Gustavo Bravim de Castro, Isabel Cristina Gomes, Maria do Carmo Friche Passos
BACKGROUND: Small intestine bacterial overgrowth is a heterogeneous syndrome characterized by an increase in the number and/or the presence of atypical microbiota in the small intestine. The symptoms of small intestine bacterial overgrowth are unspecific, encompassing abdominal pain/distension, diarrhea and flatulence. Due to the increased cost and complexity for carrying out the jejunal aspirate, the gold standard for diagnosis of the syndrome, routinely the hydrogen (H 2 ) breath test has been used, utilizing glucose or lactulose as substrate, which is able to determine, in the exhaled air, the H 2 concentration produced from the intestinal bacterial metabolism...
February 23, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28272692/gelatin-tannate-and-tyndallized-probiotics-a-novel-approach-for-treatment-of-diarrhea
#18
L Lopetuso, C Graziani, A Guarino, A Lamborghini, S Masi, V Stanghellini
OBJECTIVE: Intestinal permeability impairment is implicated in many gastrointestinal (GI) diseases. Chronic diarrhea, defined as the presence of diarrhea for more than 3 weeks in adults and 2 weeks in children, requires a different diagnostic and therapeutic work-up than acute diarrhea. Gelatin tannate, by reducing the clinical activity of acute colitis and the proinflammatory effects of lipopolysaccharide (LPS), is emerging as a mucosal barrier protector. MATERIALS AND METHODS: New therapeutic strategies focusing on the physiological function of the intestinal barrier, may offer an innovative approach for the clinical improvement of highly debilitating chronic GI diseases...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28267828/satoyoshi-syndrome-with-progressive-orofacial-manifestations-a-case-history-report
#19
Jian Li, Dong Peng, Ting Jiang, Limor Avivi-Arber
A young female patient suffering from Satoyoshi syndrome had the first characteristic signs and symptoms of hair loss and progressive spontaneous intermittent painful spasms of limb muscles at age 6.5 years. Thereafter, she developed chronic diarrhea, amenorrhea, and skeletal deformities. In the orofacial region, she suffered from painful spasms of the masseter (jaw closing) muscles, progressive tooth loss, and degeneration of the mandibular condyles. Treatment with steroids and provision of complete dentures improved the signs and symptoms...
March 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28261667/protein-malnutrition-modifies-innate-immunity-and-gene-expression-by-intestinal-epithelial-cells-and-human-rotavirus-infection-in-neonatal-gnotobiotic-pigs
#20
Anastasia N Vlasova, Francine C Paim, Sukumar Kandasamy, Moyasar A Alhamo, David D Fischer, Stephanie N Langel, Loic Deblais, Anand Kumar, Juliet Chepngeno, Lulu Shao, Huang-Chi Huang, Rosario A Candelero-Rueda, Gireesh Rajashekara, Linda J Saif
Malnutrition affects millions of children in developing countries, compromising immunity and contributing to increased rates of death from infectious diseases. Rotavirus is a major etiological agent of childhood diarrhea in developing countries, where malnutrition is prevalent. However, the interactions between the two and their combined effects on immune and intestinal functions are poorly understood. In this study, we used neonatal gnotobiotic (Gn) pigs transplanted with the fecal microbiota of a healthy 2-month-old infant (HIFM) and fed protein-deficient or -sufficient bovine milk diets...
March 2017: MSphere
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