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https://www.readbyqxmd.com/read/29154932/correlation-of-virtual-reality-simulation-and-dry-lab-robotic-technical-skills
#1
Laura K Newcomb, Megan S Bradley, Tracy Truong, Michelle Tang, Bryan Comstock, Yi-Ju Li, Anthony G Visco, Nazema Y Siddiqui
STUDY OBJECTIVE: To examine whether a set of virtual reality (VR) surgical simulation drills have correlative validity when compared to the validated Robotic Objective Structured Assessment of Technical Skills (R-OSATS) dry lab drills. DESIGN: A prospective methods comparison study (Canadian Task Force II-2). SETTING: A teaching hospital. PARTICIPANTS: Thirty current residents, fellows, and faculty from the departments of OB/GYN, Urology, and General Surgery...
November 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29028652/novel-dry-lab-training-method-for-totally-endoscopic-coronary-anastomosis-a-pilot-study
#2
Kosuke Ujihira, Akira Yamada
OBJECTIVE: We describe our original dry-lab training system for nonrobotic and beating heart endoscopic coronary artery anastomosis. METHODS: All the materials used for this training were commercially available. We selected a boxed machine, which can produce pulsatile movements of artificial vessels, and on its roof, we installed a two-dimensional home video camera and a monitor. A multiple-holed plate was placed in front of the machine, and through these holes, a trainee inserted endoscopic surgical instruments and anastomosed the artificial vessels by running fashion while watching the monitor...
September 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28834266/synthesis-enzyme-inhibitory-kinetics-and-computational-studies-of-novel-1-2-4-isobutylphenyl-propanoyl-3-arylthioureas-as-jack-bean-urease-inhibitors
#3
Tanzeela Abdul Fattah, Aamer Saeed, Pervaiz Ali Channar, Zaman Ashraf, Qamar Abbas, Mubashir Hassan, Fayaz Ali Larik
In this article synthesis of a novel 1-(2-(4-isobutylphenyl)propanoyl)-3-arylthioureas (4a-j) as jack bean urease inhibitors has been described. Freshly prepared 2-(4-isobutylphenyl) propanoyl isothiocyanate was treated with substituted aromatic anilines in one pot using anhydrous acetone. The compounds 4e, 4h and 4j showed IC50 values 0.0086nM, 0.0081nM and 0.0094nM respectively. The enzyme inhibitory kinetics results showed that compound 4h inhibit the enzyme competitively while derivatives 4e and 4j are the mixed type inhibitors...
August 21, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28734971/robotic-assistance-confers-ambidexterity-to-laparoscopic-surgeons
#4
Souzana Choussein, Serene S Srouji, Leslie V Farland, Ashley Wietsma, Stacey A Missmer, Michael Hollis, Richard N Yu, Charles N Pozner, Antonio R Gargiulo
STUDY OBJECTIVE: To examine whether a robotic surgical platform can complement the fine motor skills of the non-dominant hand, compensating for the innate difference in dexterity between the surgeon's hands, thereby conferring virtual ambidexterity. DESIGN: Crossover intervention study. DESIGN CLASSIFICATION: Level II-1 evidence. SETTING: Centers for medical simulation of two tertiary care hospitals of Harvard Medical School...
July 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28720354/training-modalities-in-robot-assisted-urologic-surgery-a-systematic-review
#5
REVIEW
Catherine Elizabeth Lovegrove, Oussama Elhage, M Shamim Khan, Giacomo Novara, Alex Mottrie, Prokar Dasgupta, Kamran Ahmed
CONTEXT: Novel surgical techniques demand that surgical training adapts to the need for technical and nontechnical skills. OBJECTIVE: To identify training methods available for robot-assisted surgical (RAS) training in urology, evaluate their effectiveness in terms of validation, educational impact, acceptability, and cost effectiveness, and assess their effect on learning curves (LCs). EVIDENCE ACQUISITION: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines searched Ovid Medline, Embase, PsycINFO, and the Cochrane Library...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28643868/the-potassium-battery-a-mobile-energy-source-for-transport-processes-in-plant-vascular-tissues
#6
REVIEW
Ingo Dreyer, Judith Lucia Gomez-Porras, Janin Riedelsberger
Contents I. II. III. IV. V. VI. VII. VIII. References SUMMARY: Plant roots absorb potassium ions from the soil and transport them in the xylem via the transpiration stream to the shoots. There, in source tissues where sufficient chemical energy (ATP) is available, K(+) is loaded into the phloem and then transported with the phloem stream to other parts of the plant; in part, transport is also back to the roots. This, at first sight, futile cycling of K(+) has been uncovered to be part of a sophisticated mechanism that (1) enables the shoot to communicate its nutrient demand to the root, (2) contributes to the K(+) nutrition of transport phloem tissues and (3) transports energy stored in the K(+) gradient between phloem cytosol and the apoplast...
June 23, 2017: New Phytologist
https://www.readbyqxmd.com/read/28572181/how-do-you-like-your-science-wet-or-dry-how-two-lab-experiences-influence-student-understanding-of-science-concepts-and-perceptions-of-authentic-scientific-practice
#7
Maureen Munn, Randy Knuth, Katie Van Horne, Andrew W Shouse, Sheldon Levias
This study examines how two kinds of authentic research experiences related to smoking behavior-genotyping human DNA (wet lab) and using a database to test hypotheses about factors that affect smoking behavior (dry lab)-influence students' perceptions and understanding of scientific research and related science concepts. The study used pre and post surveys and a focus group protocol to compare students who conducted the research experiences in one of two sequences: genotyping before database and database before genotyping...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28542395/carvacrol-derivatives-as-mushroom-tyrosinase-inhibitors-synthesis-kinetics-mechanism-and-molecular-docking-studies
#8
Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip
The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to possess potent tyrosinase inhibitory activity.The structures of the synthesized compounds were ascertained by their spectroscopic data (FTIR, 1HNMR, 13CNMR and Mass Spectroscopy).Mushroom tyrosinase inhibitory activity of synthesized compounds was determined and it was found that one of the derivative 6c possess higher activity (IC50 0...
2017: PloS One
https://www.readbyqxmd.com/read/28516300/predicting-surgical-skill-from-the-first-n-seconds-of-a-task-value-over-task-time-using-the-isogony-principle
#9
Anna French, Thomas S Lendvay, Robert M Sweet, Timothy M Kowalewski
PURPOSE: Most evaluations of surgical workflow or surgeon skill use simple, descriptive statistics (e.g., time) across whole procedures, thereby deemphasizing critical steps and potentially obscuring critical inefficiencies or skill deficiencies. In this work, we examine off-line, temporal clustering methods that chunk training procedures into clinically relevant surgical tasks or steps during robot-assisted surgery. METHODS: Features calculated from the isogony principle are used to train four common machine learning algorithms from dry-lab laparoscopic data gathered from three common training exercises...
July 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28413632/is-in-vivo-laparoscopic-simulation-learning-a-step-forward-in-the-undergraduate-surgical-education
#10
Panteleimon Pantelidis, Michail Sideris, Georgios Tsoulfas, Efstratia-Maria Georgopoulou, Ismini Tsagkaraki, Nikolaos Staikoglou, Georgios Stagias, Nikolaos Psychalakis, Parmenion Tsitsopoulos, Thanos Athanasiou, Georgios Zografos, Apostolos Papalois
BACKGROUND: Essentials Skills in the Management of Surgical Cases - ESMSC is an International Combined Applied Surgical Science and Wet Lab course addressed at the Undergraduate level. Laparoscopic Skills is a fundamental element of Surgical Education and various Simulation-Based Learning (SBL) models have been endorsed. This study aims to explore if there is any significant difference in delegates' performance depending on whether they completed In Vivo module prior to the equivalent in the laparoscopic simulator...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28376609/simulation-training-in-upper-tract-endourology-myth-or-reality-critical-analysis-of-the-literature
#11
Catherine E Lovegrove, Takashige Abe, Abdullatif Aydin, Domenico Veneziano, Kemal Sarica, M Shamim Khan, Prokar Dasgupta, Kamran Ahmed
Surgeons training in the twenty-first century are subject to a myriad of pressures, as has always been the case within surgical training. These include reduced hours available for training and increased threat of litigation against their operating practice. The Halstedian approach of "see one, do one, teach one" has been replaced within surgical training and simulation has become established to enable urology trainees to develop technical and non-technical skills away from the operating room. With the primary focus as patient safety and increasing operating skill, "simulation training" encompasses several modalities...
March 30, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28315241/silpronaq-a-convenient-approach-for-proteome-wide-analysis-of-protein-n-termini-and-n-terminal-acetylation-quantitation
#12
Willy V Bienvenut, Carmela Giglione, Thierry Meinnel
Protein N-terminal modifications have recently been involved in overall proteostasis through their impact on cell fate and protein life time. This explains the development of new approaches to characterize more precisely the N-terminal end of mature proteins. Although few approaches are available to perform N-terminal enrichment based on positive or negative discriminations, these methods are usually restricted to the enrichment in N-terminal peptides and their characterization by mass spectrometry. Recent investigation highlights both (1) the knowledge of the N-terminal acetylation status of most cytosolic proteins and (2) post-translational addition of this modification on the N-terminus of nuclear coded chloroplast proteins imported in the plastid and after the cleavage of the transit peptide...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28117766/combining-wet-and-dry-lab-techniques-to-guide-the-crystallization-of-large-coiled-coil-containing-proteins
#13
Jenna K Zalewski, Simone Heber, Joshua H Mo, Keith O'Conor, Jeffrey D Hildebrand, Andrew P VanDemark
Obtaining crystals for structure determination can be a difficult and time consuming proposition for any protein. Coiled-coil proteins and domains are found throughout nature, however, because of their physical properties and tendency to aggregate, they are traditionally viewed as being especially difficult to crystallize. Here, we utilize a variety of quick and simple techniques designed to identify a series of possible domain boundaries for a given coiled-coil protein, and then quickly characterize the behavior of these proteins in solution...
January 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27909613/the-novel-laparoscopic-training-3d-model-in-urology-with-surgical-anatomic-remarks-fresh-frozen-cadaveric-tissue
#14
REVIEW
Emre Huri, Mehmet Ezer, Eddie Chan
Laparoscopic surgery is routinely used to treat many urological conditions and it is the gold standard treatment option for many surgeries such as radical nephrectomy. Due to the difficulty of learning, laparoscopic training should start outside the operating room. Although it is a very different model of laparoscopic training; the aim of this review is to show the value of human cadaveric model for laparoscopic training and present our experience in this area. Fresh frozen cadaveric model in laparoscopic training, dry lab, cadaveric model, animal models and computer based simulators are the most commonly used models for laparoscopic training...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27720020/exome-and-genome-sequencing-for-inborn-errors-of-immunity
#15
REVIEW
Isabelle Meyts, Barbara Bosch, Alexandre Bolze, Bertrand Boisson, Yuval Itan, Aziz Belkadi, Vincent Pedergnana, Leen Moens, Capucine Picard, Aurélie Cobat, Xavier Bossuyt, Laurent Abel, Jean-Laurent Casanova
The advent of next-generation sequencing (NGS) in 2010 has transformed medicine, particularly the growing field of inborn errors of immunity. NGS has facilitated the discovery of novel disease-causing genes and the genetic diagnosis of patients with monogenic inborn errors of immunity. Whole-exome sequencing (WES) is presently the most cost-effective approach for research and diagnostics, although whole-genome sequencing offers several advantages. The scientific or diagnostic challenge consists in selecting 1 or 2 candidate variants among thousands of NGS calls...
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27647728/developing-and-assessing-a-cadaveric-training-model-for-transanal-total-mesorectal-excision-initial-experience-in-the-uk-and-usa
#16
M Penna, M Whiteford, R Hompes, P Sylla
AIM: Transanal total mesorectal excision (taTME) has become one of the most promising technical advancements in the surgical treatment of rectal cancer, with rising numbers of surgeons seeking training. We describe our experience with human cadaveric courses for taTME delivered in two countries. METHOD: Four fresh human cadaveric workshops conducted in Oxford, UK, in 2015 and two in Chicago, USA, in 2013-2014, trained a total of 52 surgeons. Parameters of operative performance for each delegate were recorded...
May 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27549358/simulation-based-training-and-assessment-in-urological-surgery
#17
REVIEW
Abdullatif Aydin, Nicholas Raison, Muhammad Shamim Khan, Prokar Dasgupta, Kamran Ahmed
Simulation has become widely accepted as a supplementary method of training. Within urology, the greatest number of procedure-specific models and subsequent validation studies have been carried out in the field of endourology. Many generic-skills simulators have been created for laparoscopic and robot-assisted surgery, but only a limited number of procedure-specific models are available. By contrast, open urological simulation has only seen a handful of validated models. Of the available modalities, virtual reality (VR) simulators are most commonly used for endourology and robotic surgery training, the former also employing many high-fidelity bench models...
September 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27403622/the-role-of-crowdsourcing-in-assessing-surgical-skills
#18
REVIEW
Andrew J Katz
BACKGROUND: Assessing surgical skill is critical in improving patient care while reducing medical errors, length of stay, and readmission rates. Crowdsourcing provides 1 potential method for accurately assessing this; only recently has crowdsourcing been studied as a valid way to provide feedback to surgeons. The results of such studies are explored. DATA SOURCES: A systematic literature search was performed on PubMed to identify studies that have attempted to validate crowdsourcing as a method for assessing surgical skill...
August 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27365004/crowdsourcing-a-valid-alternative-to-expert-evaluation-of%C3%A2-robotic-surgery%C3%A2-skills
#19
COMPARATIVE STUDY
Michael R Polin, Nazema Y Siddiqui, Bryan A Comstock, Helai Hesham, Casey Brown, Thomas S Lendvay, Martin A Martino
BACKGROUND: Robotic-assisted gynecologic surgery is common, but requires unique training. A validated assessment tool for evaluating trainees' robotic surgery skills is Robotic-Objective Structured Assessments of Technical Skills. OBJECTIVE: We sought to assess whether crowdsourcing can be used as an alternative to expert surgical evaluators in scoring Robotic-Objective Structured Assessments of Technical Skills. STUDY DESIGN: The Robotic Training Network produced the Robotic-Objective Structured Assessments of Technical Skills, which evaluate trainees across 5 dry lab robotic surgical drills...
November 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27278686/biomarker-discovery-using-dry-lab-technologies-and-high-throughput-screening
#20
Hao-Teng Chang
No abstract text is available yet for this article.
June 2016: Biomarkers in Medicine
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