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https://www.readbyqxmd.com/read/27909613/the-novel-laparoscopic-training-3d-model-in-urology-with-surgical-anatomic-remarks-fresh-frozen-cadaveric-tissue
#1
REVIEW
Emre Huri, Mehmet Ezer, Eddie Chan
Laparoscopic surgery is routinely used to treat many urological conditions and it is the gold standard treatment option for many surgeries such as radical nephrectomy. Due to the difficulty of learning, laparoscopic training should start outside the operating room. Although it is a very different model of laparoscopic training; the aim of this review is to show the value of human cadaveric model for laparoscopic training and present our experience in this area. Fresh frozen cadaveric model in laparoscopic training, dry lab, cadaveric model, animal models and computer based simulators are the most commonly used models for laparoscopic training...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27720020/exome-and-genome-sequencing-for-inborn-errors-of-immunity
#2
REVIEW
Isabelle Meyts, Barbara Bosch, Alexandre Bolze, Bertrand Boisson, Yuval Itan, Aziz Belkadi, Vincent Pedergnana, Leen Moens, Capucine Picard, Aurélie Cobat, Xavier Bossuyt, Laurent Abel, Jean-Laurent Casanova
The advent of next-generation sequencing (NGS) in 2010 has transformed medicine, particularly the growing field of inborn errors of immunity. NGS has facilitated the discovery of novel disease-causing genes and the genetic diagnosis of patients with monogenic inborn errors of immunity. Whole-exome sequencing (WES) is presently the most cost-effective approach for research and diagnostics, although whole-genome sequencing offers several advantages. The scientific or diagnostic challenge consists in selecting 1 or 2 candidate variants among thousands of NGS calls...
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27647728/developing-and-assessing-a-cadaveric-training-model-for-transanal-total-mesorectal-excision-initial-experience-in-the-uk-and-usa
#3
Marta Penna, Mark Whiteford, Roel Hompes, Patricia Sylla
AIM: Transanal Total Mesorectal Excision (taTME) has become one of the most promising technical advancement in the surgical treatment of rectal cancer, with rising numbers of surgeons seeking training. We describe our experience with human cadaveric courses for taTME delivered in two countries. METHOD: Four fresh human cadaveric workshops conducted in Oxford, UK in 2015 and two in Chicago, USA in 2013-2014, trained a total of 52 surgeons. Parameters of operative performance for each delegate were recorded...
September 19, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27549358/simulation-based-training-and-assessment-in-urological-surgery
#4
REVIEW
Abdullatif Aydin, Nicholas Raison, Muhammad Shamim Khan, Prokar Dasgupta, Kamran Ahmed
Simulation has become widely accepted as a supplementary method of training. Within urology, the greatest number of procedure-specific models and subsequent validation studies have been carried out in the field of endourology. Many generic-skills simulators have been created for laparoscopic and robot-assisted surgery, but only a limited number of procedure-specific models are available. By contrast, open urological simulation has only seen a handful of validated models. Of the available modalities, virtual reality (VR) simulators are most commonly used for endourology and robotic surgery training, the former also employing many high-fidelity bench models...
September 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27403622/the-role-of-crowdsourcing-in-assessing-surgical-skills
#5
Andrew J Katz
BACKGROUND: Assessing surgical skill is critical in improving patient care while reducing medical errors, length of stay, and readmission rates. Crowdsourcing provides 1 potential method for accurately assessing this; only recently has crowdsourcing been studied as a valid way to provide feedback to surgeons. The results of such studies are explored. DATA SOURCES: A systematic literature search was performed on PubMed to identify studies that have attempted to validate crowdsourcing as a method for assessing surgical skill...
August 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27365004/crowdsourcing-a-valid-alternative-to-expert-evaluation-of%C3%A2-robotic-surgery%C3%A2-skills
#6
Michael R Polin, Nazema Y Siddiqui, Bryan A Comstock, Helai Hesham, Casey Brown, Thomas S Lendvay, Martin A Martino
BACKGROUND: Robotic-assisted gynecologic surgery is common, but requires unique training. A validated assessment tool for evaluating trainees' robotic surgery skills is Robotic-Objective Structured Assessments of Technical Skills. OBJECTIVE: We sought to assess whether crowdsourcing can be used as an alternative to expert surgical evaluators in scoring Robotic-Objective Structured Assessments of Technical Skills. STUDY DESIGN: The Robotic Training Network produced the Robotic-Objective Structured Assessments of Technical Skills, which evaluate trainees across 5 dry lab robotic surgical drills...
June 27, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27278686/biomarker-discovery-using-dry-lab-technologies-and-high-throughput-screening
#7
Hao-Teng Chang
No abstract text is available yet for this article.
June 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27246302/robotic-surgical-training-where-are-we
#8
REVIEW
Jonathan R Foote, Fidel A Valea
BACKGROUND AND OBJECTIVE: Over the past 10years, robotic surgery has revolutionized the advancement of MIS in gynecologic oncology. As the use of robotic surgery has increased, so has the interest in the surgical training of gynecologic oncology fellows. The purpose of this review is to summarize the state of robotic surgical education in Gynecologic Oncology. METHODS: Several electronic databases were searched to identify studies that discussed robotic surgical education in gynecologic oncology...
October 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27240674/genetic-and-genomic-dissection-of-prolactin-revealed-potential-association-with-milk-production-traits-in-riverine-buffalo
#9
A Nadeem, J Maryam
Milk yield and quality has been a major selection criterion for genetic improvement in livestock species. Role of Prolactin gene in determining milk quality in terms of protein profile, lactose, lipids and other imperative macromolecules is very important. In this context, genetic profiling of Prolactin gene in riverine buffalo of Pakistan was performed and potential genetic markers were identified illustrating worth of this gene in marker-assisted selection of superior dairy buffaloes. Series of wet and dry lab experimentation was performed starting with genomic DNA isolation from true to breed representatives of indigenous river buffalo (Nili-Ravi)...
August 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27185502/a-review-of-gene-knockout-strategies-for-microbial-cells
#10
REVIEW
Phooi Wah Tang, Pooi San Chua, Shiue Kee Chong, Mohd Saberi Mohamad, Yee Wen Choon, Safaai Deris, Sigeru Omatu, Juan Manuel Corchado, Weng Howe Chan, Raha Abdul Rahim
BACKGROUND: Predicting the effects of genetic modification is difficult due to the complexity of metabolic net- works. Various gene knockout strategies have been utilised to deactivate specific genes in order to determine the effects of these genes on the function of microbes. Deactivation of genes can lead to deletion of certain proteins and functions. Through these strategies, the associated function of a deleted gene can be identified from the metabolic networks. METHODS: The main aim of this paper is to review the available techniques in gene knockout strategies for microbial cells...
2015: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27013278/establishing-benchmarks-for-minimum-competence-with-dry-lab-robotic-surgery-drills
#11
Nazema Y Siddiqui, Megan E Tarr, Elizabeth J Geller, Arnold P Advincula, Michael L Galloway, Isabel C Green, Hye-Chun Hur, Michael C Pitter, Emily E Burke, Martin A Martino
The Robotic Objective Structured Assessment of Technical Skills (R-OSATS) is a previously validated assessment tool that is used to assess 5 standardized inanimate robotic surgery drills. R-OSATS is used to evaluate performance on surgical drills, with scores of 0 to 20 for each drill. Our objective was to establish the minimum threshold score that denotes competence on these drills. Thus, we performed a standard setting study using data from surgeons and trainees in 8 academic medical centers. Cutoff scores for the minimal level of competence using R-OSATS were established using 2 techniques: the modified Angoff and the contrasting groups methods...
May 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/26964911/evaluation-of-robotic-cardiac-surgery-simulation-training-a-randomized-controlled-trial
#12
Matthew Valdis, Michael W A Chu, Christopher Schlachta, Bob Kiaii
OBJECTIVE: To compare the currently available simulation training modalities used to teach robotic surgery. METHODS: Forty surgical trainees completed a standardized robotic 10-cm dissection of the internal thoracic artery and placed 3 sutures of a mitral valve annuloplasty in porcine models and were then randomized to a wet lab, a dry lab, a virtual reality lab, or a control group that received no additional training. All groups trained to a level of proficiency determined by 2 expert robotic cardiac surgeons...
June 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26914650/beyond-2d-telestration-an-evaluation-of-novel-proctoring-tools-for-robot-assisted-minimally-invasive-surgery
#13
Anthony M Jarc, Swar H Shah, Troy Adebar, Eric Hwang, Monish Aron, Inderbir S Gill, Andrew J Hung
Experienced surgeons commonly mentor trainees as they move through their initial learning curves. During robot-assisted minimally invasive surgery, several tools exist to facilitate proctored cases, such as two-dimensional telestration and a dual surgeon console. The purpose of this study was to evaluate the utility and efficiency of three, novel proctoring tools for robot-assisted minimally invasive surgery, and to compare them to existing proctoring tools. Twenty-six proctor-trainee pairs completed validated, dry-lab training exercises using standard two-dimensional telestration and three, new three-dimensional proctoring tools called ghost tools...
June 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/26892059/robotic-vr-simulation-to-measure-competency-a-step-in-the-right-direction
#14
COMMENT
Costas D Lallas
No abstract text is available yet for this article.
February 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/26799843/a-computational-investigation-on-the-substrate-preference-of-ten-eleven-translocation-2-tet2
#15
Junyan Lu, Lulu Hu, Jingdong Cheng, Dong Fang, Chen Wang, Kunqian Yu, Hualiang Jiang, Qiang Cui, Yanhui Xu, Cheng Luo
TET proteins iteratively convert 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in a Fe(ii)/α-ketoglutarate-dependent manner. Our previous biochemical studies revealed that TET proteins are more active on 5mC than on 5hmC and 5fC. However, the source of the substrate preference of TET proteins still remains largely elusive. Here, we investigated the substrate binding and catalytic mechanisms of oxidation reactions mediated by TET2 on different substrates through computational approaches...
February 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/26716983/mirlab-an-r-based-dry-lab-for-exploring-mirna-mrna-regulatory-relationships
#16
Thuc Duy Le, Junpeng Zhang, Lin Liu, Huawen Liu, Jiuyong Li
microRNAs (miRNAs) are important gene regulators at post-transcriptional level, and inferring miRNA-mRNA regulatory relationships is a crucial problem. Consequently, several computational methods of predicting miRNA targets have been proposed using expression data with or without sequence based miRNA target information. A typical procedure for applying and evaluating such a method is i) collecting matched miRNA and mRNA expression profiles in a specific condition, e.g. a cancer dataset from The Cancer Genome Atlas (TCGA), ii) applying the new computational method to the selected dataset, iii) validating the predictions against knowledge from literature and third-party databases, and comparing the performance of the method with some existing methods...
2015: PloS One
https://www.readbyqxmd.com/read/26661411/robotic-assisted-laparoscopic-prostatectomy-ralp-a-new-way-to-training
#17
Raphael Rocha, Rossano Kepler Alvim Fiorelli, Gilberto Buogo, Maurício Rubistein, Rogério Moraes Mattos, Rodrigo Frota, Rafael Ferreira Coelho, Kenneth Palmer, Vipul Patel
The implementation of RALP program is usually associated with a steep learning curve (LC). Fellows are proctored for few cases, with long operating times, inferior outcomes and an increased number of complications. We report the initial results of 100 RALP procedures performed in Rio de Janeiro, Brazil, with the implementation of a structured program. Our goal was to evaluate if our approach to training would yield a safer outcomes for patients undergoing the procedure during the LC. From October 2012 to January 2014, five surgeons began a training program in RALP...
March 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/26650760/uncovering-the-molecular-mechanism-of-actions-between-pharmaceuticals-and-proteins-on-the-ad-network
#18
Shujuan Cao, Liang Yu, Jingyuan Mao, Quan Wang, Jishou Ruan
This study begins with constructing the mini metabolic networks (MMNs) of beta amyloid (Aβ) and acetylcholine (ACh) which stimulate the Alzheimer's Disease (AD). Then we generate the AD network by incorporating MMNs of Aβ and ACh, and other MMNs of stimuli of AD. The panel of proteins contains 49 enzymes/receptors on the AD network which have the 3D-structure in PDB. The panel of drugs is formed by 5 AD drugs and 5 AD nutraceutical drugs, and 20 non-AD drugs. All of these complexes formed by these 30 drugs and 49 proteins are transformed into dyadic arrays...
2015: PloS One
https://www.readbyqxmd.com/read/26530968/development-and-testing-of-a-robotic-surgical-training-curriculum-for-novice-surgeons
#19
Sondra Summers, Jennifer Anderson, Amy Petzel, Megan Tarr, Kimberly Kenton
A robotics practice curriculum was developed utilizing dry lab skills and testing parameters based upon the objective structured assessment of surgical tasks (OSATS) to determine its effectiveness in training novice surgeons. We recruited 20 medical students who were oriented to the DaVinci S console and instrumentation. They were pre-tested with four dry lab skills including manipulation, transection, suturing and knot tying. A control group was instructed to practice once weekly to attain proficiency and the intervention group was provided specific instructions regarding practice goals...
March 2015: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/25555724/peptide-toxicity-prediction
#20
Sudheer Gupta, Pallavi Kapoor, Kumardeep Chaudhary, Ankur Gautam, Rahul Kumar, Gajendra P S Raghava
Last decade has witnessed the revival of interest in peptides as potential therapeutics candidates. However, one of the bottlenecks in the success of therapeutic peptides in clinics is their toxicity towards eukaryotic cells. Therefore, considerable efforts have been made over the years both in wet and dry lab to overcome this limitation. With the advances in peptide synthesis, now it is possible to fine-tune the physicochemical properties of peptides by incorporating several chemical modifications and thus to optimize the peptide functionality in order to minimize the toxicity without compromising their therapeutic activity...
2015: Methods in Molecular Biology
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