Asmat Ullah, Evelina Stankevic, Louise Aas Holm, Sara E Stinson, Helene Bæk Juel, Cilius E Fonvig, Morten A V Lund, Cæcilie Trier, Line Engelbrechtsen, Lars Ängquist, Anna E Jonsson, Oluf Pedersen, Niels Grarup, Jens-Christian Holm, Torben Hansen
Bilirubin is the end product of heme catabolism, mainly produced by the breakdown of mature red blood cells. Due to its anti-inflammatory, antioxidant, antidiabetic, and antilipemic properties, circulating bilirubin concentrations are inversely associated with the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality in adults. Some genetic loci associated with circulating bilirubin concentrations have been identified by genome-wide association studies in adults. We aimed to examine the relationship between circulating bilirubin, cardiometabolic risk factors, and inflammation in children and adolescents and the genetic architecture of plasma bilirubin concentrations...
August 15, 2023: Antioxidants (Basel, Switzerland)