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osteoporosis and running

Xi Chen, Lihui Li, Jianmin Guo, Lingli Zhang, Yu Yuan, Binglin Chen, Zhongguang Sun, Jiake Xu, Jun Zou
This study examined the effects of different exercise intensities and durations on bone mineral density (BMD) and bone strength in senescence-accelerated mouse prone 6 (SAMP6) and determined the involvement of the Wnt signaling pathway in exercise-induced osteogenesis. Three-month-old male SAMP6 mice were randomly assigned to different speeds of treadmill running exercise representing low, medium and high intensity, with the duration of five and nine weeks, respectively. We showed that medium-intensity exercise had positive effects on skeletal health, including BMD and bone strength, and the efficacy was higher than that of low-intensity exercise...
September 19, 2016: Oncotarget
Morteza Dehghan, Razieh Pourahmad-Jaktaji
INTRODUCTION: Vitamin D receptor gene is one of candidate genes related to osteoporosis expansion. The association of ApaI, TaqI, BsmI polymorphisms in vitamin D receptor gene with bone metabolism and density has been area of interest in many studies. AIM: This study was conducted to further investigate the association between the ApaI, TaqI, BsmI polymorphisms and bone density. This study was analytical study. Centers for bone density measurement in southwestern Iran...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Ripalta Colìa, Addolorata Corrado, Francesco Paolo Cantatore
Inflammatory bowel diseases (IBDs) often present as a complex inflammatory process wherein colon lesions (ulcerative colitis, UC) or widespread ulceration and fissure (Crohn's disease, CD) might be accompanied by ancillary extraintestinal manifestations (EIMs) that could involve almost every organ system, but also by autoimmune disorders ranging from psoriasis and rheumatoid arthritis to connective tissue diseases. Certain EIMs are more common related to the activity of the IBD (joint, skin, ocular and oral manifestations), other EIMs typically run a course independent of the IBD activity (hepatobiliary disorders) and some are non-specific disorders (osteoporosis and amyloidosis)...
June 16, 2016: Annals of Medicine
Liang Tang, Xiaohang Gao, Xiaoying Yang, Didi Zhang, Xiaojun Zhang, Haiping Du, Yanqi Han, Lijun Sun
Weight-bearing exercise is beneficial to bone health. Myostatin (MSTN) deficiency has a positive effect on bone formation. We wondered if a combination of weight-bearing training and polyclonal antibody for MSTN (MsAb) would augment bone formation to a greater degree than single treatment. In this study, rats were randomly assigned to four groups: Control, weight-bearing training (WT), MsAb, and WT+MsAb. The trained rats ran at 15 m/min bearing with 35% of their body weight, 40 min/day (2 min of running followed by 2 min of rest), 6 days/week, for 8 weeks...
April 20, 2016: International Journal of Sport Nutrition and Exercise Metabolism
Tom Richardson, Michael Grant, Prakash Chandran
Femoral neck stress fractures in young healthy individuals are rare and occur in those who take part in physical training with repetitive loading and those with osteoporosis. Bone density is related to sex hormone status, which is artificially manipulated during gender reassignment. Conflicting evidence currently exists on the effect of cross sex hormone treatment on bone density, with no literature suggesting a link between hormone treatment in gender reassignment and stress fractures. Our aim is to highlight the potential risk of stress fractures amongst transsexual patients receiving cross sex hormones as part of gender reassignment...
2016: BMJ Case Reports
Márcio Passini Gonçalves de Souza
Articles that update the state of knowledge regarding osteoporosis run the risk of quickly becoming obsolete because research and studies on osteoporosis today are arousing great interest among researchers, the pharmaceutical and medical equipment industries, governments and even WHO. All orthopedists know about osteoporosis because of its most deleterious effect: osteoporotic fracture. Osteoporosis without fractures does not arouse suspicion because this is a pathological condition with a nonspecific clinical profile...
May 2010: Revista Brasileira de Ortopedia
Dirk Wildemeersch
OBJECTIVE: The use of a levonorgestrel intrauterine system (LNG-IUS) is useful in preventing pregnancy and for the treatment of menstrual disturbances. A smooth or symptom-free transition to and through menopause is possible when LNG-IUS is combined with estrogen therapy. Unfortunately the majority of physicians are generally unaware of this usefulness combined hormonal therapy in the pre-, peri- and postmenopausal women. DESIGN AND METHOD: Based on long-term clinical experience with LNG-IUS in the form of Femilis®, 104 women where followed from the premenopause through the menopausal transition into the postmenopause...
March 1, 2016: Gynecological Endocrinology
Nadezhda G Gumanova, Alexander D Deev, Marina V Klimushina, Alexander Y Kots, Svetlana A Shalnova
BACKGROUND: Nitric oxide and its metabolites, nitrate and nitrite, are important regulators linked various diseases. We studied the association of fasting serum concentrations of nitrate and nitrite, combined as NOx, without special diet, with the prevalence of various chronic diseases. METHODS: We have assayed fasting concentrations of NOx in a cohort of 1087 patients recruited to Stress Aging and Health in Russia study that represents male and female population in Moscow, Russia, over 55 years of age...
February 19, 2016: International Angiology: a Journal of the International Union of Angiology
N Suhm, C Meier, M Kraenzlin, E Kungler, B Savic, S Mueller, M Jakob, D Rikli
The increasing importance of preventive measures in the field of orthopedics and trauma surgery becomes apparent because of the demographic changes and the high risk for secondary fractures following osteoporotic fractures. Within the fracture treatment chain, orthopedics and trauma surgery are in the "pole position" to initiate these measures in geriatric patients. In the past orthopedists and trauma surgeons have constantly accused of neglecting secondary fracture prevention in fragility fracture patients...
January 2016: Der Unfallchirurg
Z J Daruwalla, S S Huq, K L Wong, P Y Nee, K M Leong, K R Pillay, D P Murphy
UNLABELLED: Both men and women who sustain a fracture of the distal forearm run an increased risk of sustaining a subsequent hip fracture. Our study implies that these patients may not necessarily constitute a group in which osteoporosis screening is warranted. INTRODUCTION: People who sustain a distal radius fracture run an increased risk of sustaining a subsequent hip fracture. However, many institutions only screen for osteoporosis at the time of a hip fracture...
January 2016: Osteoporosis International
Nele Cielen, Karen Maes, Nele Heulens, Thierry Troosters, Geert Carmeliet, Wim Janssens, Ghislaine N Gayan-Ramirez
Physical inactivity is an important contributor to skeletal muscle weakness, osteoporosis, and weight loss in chronic obstructive pulmonary disease. However, the effects of physical inactivity, in interaction with smoking, on lung, muscle, and bone are poorly understood. To address this issue, male mice were randomly assigned to an active (daily running), moderately inactive (space restriction), or extremely inactive group (space restriction followed by hindlimb suspension to mimic bed rest) during 24 weeks and simultaneously exposed to either cigarette smoke or room air...
May 2016: American Journal of Respiratory Cell and Molecular Biology
Kelvin S Ng, Thomas M Kuncewicz, Jeffrey M Karp
While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigenetic changes conferred by secretory action of the MSCs.
October 6, 2015: Cell Metabolism
Harshini Katugampola, Vrinda Saraff, Anitha Kumaran, Jeremy Allgrove, Nick J Shaw
Conditions related to abnormalities of calcium and bone metabolism are large in number and are characterised by hypocalcaemia, hypercalcaemia, primary and secondary osteoporosis, rickets resulting from both vitamin D and phosphate metabolism disorders, and a series of miscellaneous conditions. Included in this chapter is a series of cases drawn from our clinics and from colleagues who have presented these clinical problems at the recent Advanced Courses in Paediatric Bone and Calcium Metabolism run by the British Paediatric and Adolescent Bone group...
2015: Endocrine Development
Tie-Lin Yang, Yan Guo, Ji-Gang Zhang, Chao Xu, Qing Tian, Hong-Wen Deng
Runs of homozygosity (ROHs), in which both parental alleles are identical, have been proposed to have recessive effects on multiple human complex diseases. Osteoporosis is a common complex disease characterized by low bone mineral density (BMD), which is highly heritable. And recessive loci that contribute to BMD variations have been identified. In this study, we performed a genome-wide ROHs association study using our SNP array data from three GWAS samples including 4,900 subjects from Caucasian and Chinese populations...
November 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Massimo Accorinti, Francesca Romana Pesci, Maria Pia Pirraglia, Roberta Priori, Paola Pivetti-Pezzi
OBJECTIVES: To report on the clinical course of ocular and extraocular involvement in a multidrug-resistant patient with Behçet's disease (BD). METHODS: A 22-year-old male with BD (bilateral panuveitis and retinal vasculitis, oral ulcers, erythema nodosum, arthralgia, epididymitis) was followed-up from 1999 to 2014. He was treated continuously with corticosteroids in combination with different immunosuppressive therapies (cyclosporine, azathioprine, methotrexate, interferon, infliximab, mycophenolate), which exerted numerous side-effects such as nephrotoxicity, nephrolithiasis, increase of liver enzymes, severe depression with suicidal ideation, severe leucopenia, pulmonary tuberculosis, pulmonary legionellosis, recurrent bronchopneumonia...
November 2015: Clinical and Experimental Rheumatology
Jennifer T Lee, Carolyn E Moore, John D Radcliffe
UNLABELLED: Calcium is an important structural component of the skeletal system. Although an adequate intake of calcium helps to maintain bone health and reduce the risk of osteoporosis, many women do not meet recommended daily intakes of calcium. Previous interventions studies designed to increase dietary intake of women have utilized primarily dairy sources of calcium or supplements. However, lactose intolerance, milk protein allergies, or food preferences may lead many women to exclude important dairy sources of dietary calcium...
2015: PloS One
Lei Si, Tania M Winzenberg, Mingsheng Chen, Qicheng Jiang, Andrew J Palmer
OBJECTIVE: To determine the residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women. METHODS: A validated state-transition microsimulation model was used. Microsimulation and probabilistic sensitivity analyses were performed to address the uncertainties in the model. All parameters including fracture incidence rates and mortality rates were retrieved from published literature. Simulated subjects were run through the model until they died to estimate the residual lifetime fracture risks...
June 2015: Current Medical Research and Opinion
Hany Farid Eid Morsy Elsisi, Gihan Samir Mohamed Mousa, Mohamed Taher Mahmoud ELdesoky
BACKGROUND AND PURPOSE: Osteoporosis is a common skeletal disorder with costly complications and a global health problem and one of the leading causes of morbidity and mortality worldwide. Magnetic field therapy and physical activity have been proven as beneficial interventions for prevention and treatment of osteoporosis. The purpose of this study was to compare the response of bone mineral content and bone mineral density (BMD) in elderly women to either low-frequency low-intensity pulsed magnetic field (LFLIPMF) or circuit weight training (CWT) on short-run basis (after 12 weeks)...
2015: Clinical Interventions in Aging
I H Murai, H Roschel, L V S Pabis, L Takayama, R B de Oliveira, R T Dos Santos Pereira, W S Dantas, R M R Pereira, V Jorgetti, R Y Ballester, B Gualano
UNLABELLED: Evidence suggests that creatine may have some beneficial effects on bone. The study aimed to investigate the effects of exercise alone or combined with creatine on bone health in ovariectomized rats. Findings show that exercise, but not creatine, has an important role in improving bone health. INTRODUCTION: The aim of this study was to investigate the effects of exercise training alone or combined with creatine supplementation on bone health parameters in ovariectomized rats...
April 2015: Osteoporosis International
Su Ryun Jung, Sang Hyun Kim, Na Young Ahn, Ki Jin Kim
PURPOSE: This study is aimed at providing clear guidance on treatment and prevention of osteoporosis by comparing and analyzing some well-known methods out of drug and exercise therapies. METHODS: For this purpose, eight-week experiments (drug therapy and exercise therapy) were carried out by using rats whose menopause was induced by the removal of an ovary. In the treatment of the drug therapy, the effects of soy protein, one of the well-known alendronate and estrogen replacement therapy, were compared and analyzed...
March 2014: Journal of Exercise Nutrition & Biochemistry
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