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osteoporosis and nutrition

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https://www.readbyqxmd.com/read/29624982/clinical-interventions-in-osteosarcopenic-obesity-nutrition-physical-and-psychological-activity
#1
Ana Isabel García-González, Zoraida Axtle-Serrano, Miriam López-Teros, Claudia Szlejf, Adrián Martínez-Ruiz, Oscar Rosas-Carrasco
Osteosarcopenic obesity (OSO) is a condition associated with adverse outcomes in older adults. Since it is a condition which includes three tissues (obesity, sarcopenia and osteopenia/osteoporosis), it requires simultaneous and multidisciplinary clinical interventions to revert it. Until this moment, there have been published review articles only focused on nutrition or physical activity. However, we believe that assembling the existing evidence on potential treatments (nutritional intervention with micro- and macronutrients), physical activity, farmacological treatment for osteopenia/osteoporosis, possible farmacological treatment for sarcopenia, and, finally, psychological interventions focused on the treatment of psychiatric comorbidities (such as anxiety or depression) will help healthcare providers to improve the body composition of older adults...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29608214/heart-rate-and-bone-mineral-density-in-older-women-with-hypertension-results-from-the-korea-national-health-and-nutritional-examination-survey
#2
Mi-Hyang Jung, Ho-Joong Youn, Sang-Hyun Ihm, Hae Ok Jung, Kyung-Soon Hong
OBJECTIVES: To determine whether high heart rate is associated with low bone mineral density (BMD) in older women with hypertension. DESIGN: Retrospective cohort study. SETTING: Population-based study conducted in Korea (Korea National Health and Nutritional Examination Survey 2009-10). PARTICIPANTS: Postmenopausal women aged 60 and older with hypertension (N=981) divided into 2 groups according to resting heart rate, with a cut-off value of 80 bpm, which has been found to be associated with osteoporosis...
April 2, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29593131/-milk-daily-products-and-bone-health-effect-of-milks-and-daily-products-on-bone-health
#3
Megumi Kubota, Rikako Inoue
In Japan, nutrition education programs to prevent osteoporosis and osteoporotic fractures have focused primarily on increasing dietary calcium intake and recommended the consumption of milk and dairy products. However, the effect of milk and dairy product consumption on bone density loss or fracture incidence in Japanese has rarely been evaluated in randomized controlled studies. In the present study, we reviewed the literature investigating the consumption of milk and dairy products in relation to bone density and fracture risk...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29574535/epigenetics-of-skeletal-diseases
#4
REVIEW
Alvaro Del Real, Leyre Riancho-Zarrabeitia, Laura López-Delgado, José A Riancho
PURPOSE OF REVIEW: Epigenetic mechanisms modify gene activity in a stable manner without altering DNA sequence. They participate in the adaptation to the environment, as well as in the pathogenesis of common complex disorders. We provide an overview of the role of epigenetic mechanisms in bone biology and pathology. RECENT FINDINGS: Extensive evidence supports the involvement of epigenetic mechanisms (DNA methylation, post-translational modifications of histone tails, and non-coding RNAs) in the differentiation of bone cells and mechanotransduction...
March 24, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29564302/new-skeletal-muscle-mass-index-in-diagnosis-of-sarcopenia
#5
Jeong Jae Moon, Sam-Guk Park, Seung Min Ryu, Chan-Ho Park
Background: We sought to develop a novel index based on the skeletal muscle mass that reflects the change of quality of life (QOL), and is the most appropriate index for the body composition of the elderly in Korea. Whether lower extremity skeletal muscle mass index (LESMI) is an appropriate novel new index to diagnose patients with sarcopenia was also evaluated. A cut-off value for each index was reported to facilitate the diagnosis of patients with sarcopenia in a Korean population...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29541429/effect-of-secondhand-smoking-determined-by-urinary-cotinine-level-on-bone-health
#6
Ji Hyun Moon, Mi Hee Kong, Hyeon Ju Kim
Background: We evaluated the relationship between secondhand smoke (SHS) inhalation, as verified by urinary cotinine levels, and bone health. Methods: We analyzed the nationwide, population-based, cross-sectional health survey. We included 1936 men aged 50 years or older who checked bone mineral density (BMD) from the Korean National Health and Nutrition Examination Survey (2008-2010). Current smokers assessed by urinary cotinine levels higher than 500 ng/mL were excluded ( n = 616)...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29532755/homocysteine-and-hyperhomocysteinaemia
#7
Bozidarka L Zaric, Milan Obradovic, Vladan Bajic, Mohamed A Haidara, Milos Jovanovic, Esma R Isenovic
Homocysteine (Hcy) is thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical reactions that are necessary for degradation of Hcy require the presence of the folic acid, vitamins B6 and B12. Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia (HHcy) and homocystinuria are connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis, chronic renal failure, megaloblastic anemia, osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29522985/persistent-organic-pollutants-and-penile-bone-mineral-density-in-east-greenland-and-canadian-polar-bears-ursus-maritimus-during-1996-2015
#8
Tobias Daugaard-Petersen, Rikke Langebæk, Frank F Rigét, Markus Dyck, Robert J Letcher, Lars Hyldstrup, Jens-Erik Bech Jensen, Rune Dietz, Christian Sonne
Persistent organic pollutants (POPs) are long-range transported to the Arctic via atmospheric and oceanic currents, where they biomagnify to high concentrations in the tissues of apex predators such as polar bears (Ursus maritimus). A major concern of POP exposure is their physiological effects on vital organ-tissues posing a threat to the health and survival of polar bears. Here we examined the relationship between selected POPs and baculum bone mineral density (BMD) in the East Greenland and seven Canadian subpopulations of polar bears...
March 6, 2018: Environment International
https://www.readbyqxmd.com/read/29518117/nuclear-receptor-and-vegf-pathways-for-gene-blood-lead-interactions-on-bone-mineral-density-in-korean-smokers
#9
Ho-Sun Lee, Taesung Park
Osteoporosis has a complex etiology and is considered a multifactorial polygenic disease, in which genetic determinants are modulated by hormonal, lifestyle, environmental, and nutritional factors. Therefore, investigating these multiple factors, and the interactions between them, might lead to a better understanding of osteoporosis pathogenesis, and possible therapeutic interventions. The objective of this study was to identify the relationship between three blood metals (Pb, Cd, and Al), in smoking and nonsmoking patients' sera, and prevalence of osteoporosis...
2018: PloS One
https://www.readbyqxmd.com/read/29509552/effects-of-essential-ad2-supplement-on-blood-acetaldehyde-levels-in-individuals-who-have-aldehyde-dehydrogenase-aldh2-deficiency
#10
Ken Fujioka, Spencer Gordon
BACKGROUND: It is estimated that 1 billion people in the world have a point mutation in the gene encoding the aldehyde dehydrogenase 2 (ALDH2) enzyme, the primary enzyme responsible for the metabolism of acetaldehyde. The presence of this mutation is called ALDH2 deficiency. Because of limited ability to metabolize acetaldehyde, individuals with ALDH2 deficiency experience elevated levels of blood acetaldehyde after exposure to various common sources such as recreational alcohol. Because of higher levels of acetaldehyde, individuals with ALDH2 deficiency are at higher risk for numerous diseases, including liver cirrhosis, esophageal and gastric cancer, osteoporosis, and Alzheimer disease...
February 21, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29509291/short-bowel-syndrome-influence-of-nutritional-therapy-and-incretin-glp1-on-bone-marrow-adipose-tissue
#11
Luciana T Parreiras-E-Silva, Iana M de Araújo, Jorge Elias, Marcello H Nogueira-Barbosa, Vivian M M Suen, Julio S Marchini, Jéssica Bonella, Andressa K Nahas, Carlos E G Salmon, Francisco J A de Paula
Energy deprivation leads to a decrease in white adipose tissue and bone mineral density (BMD), while simultaneously inducing the expansion of marrow adipose tissue (MAT). In short bowel syndrome (SBS), parenteral nutrition mitigates the deterioration of nutritional status, including decreases in MAT. Osteoporosis is, however, a frequent complication of SBS. The objective of our study here was to evaluate the association of fat deposit sites (subcutaneous and visceral adipose tissues: intrahepatic lipid (IHL) and MAT) and the incretin glucagon-like peptide 1 (GLP1) with BMD in individuals with SBS...
March 6, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29504042/bone-mineral-density-and-nutritional-status-in-children-with-quadriplegic-cerebral-palsy
#12
Citlalli Alvarez Zaragoza, Edgar Manuel Vasquez Garibay, Andrea A García Contreras, Alfredo Larrosa Haro, Enrique Romero Velarde, Alejandro Rea Rosas, José Luis Cabrales de Anda, Israel Vega Olea
This study demonstrated the relationship of low bone mineral density (BMD) with the degree of motor impairment, method of feeding, anthropometric indicators, and malnutrition in children with quadriplegic cerebral palsy (CP). The control of these factors could optimize adequate bone mineralization, avoid the risk of osteoporosis, and would improve the quality of life. PURPOSE: The purpose of the study is to explore the relationship between low BMD and nutritional status in children with quadriplegic CP...
March 4, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29503055/vitamin-d-nutritional-status-and-bone-turnover-markers-in-childhood-acute-lymphoblastic-leukemia-survivors-a-petale-study
#13
E Delvin, N Alos, F Rauch, V Marcil, S Morel, M Boisvert, M-A Lecours, C Laverdière, D Sinnett, M Krajinovic, J Dubois, S Drouin, G Lefebvre, M Samoilenko, C Nyalendo, E Cavalier, E Levy
BACKGROUND: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. OBJECTIVE: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors...
February 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29485420/hypocalcemia-after-denosumab-in-a-pulmonary-hypertension-patient-receiving-epoprostenol
#14
Benedicte De Muynck, Mathias Leys, Joke Cuypers, Dirk Vanderschueren, Marion Delcroix, Catharina Belge
We report the case of a 50-year-old woman with anorexigen-induced pulmonary arterial hypertension treated with epoprostenol, who presented with Trousseau's sign, leading to the diagnosis of severe hypocalcemia for which substitution was started (initially orally, followed by intravenous substitution). After further analysis, we assume that epoprostenol-induced diarrhea caused malabsorption (as other reasons were excluded), leading to nutritional osteomalacia with secondary hyperparathyroidism. We discovered that even more severe hypocalcemia was induced by the treatment with the anti-osteoporotic drug denosumab, which was started after the diagnosis of osteoporosis on bone densitometry...
2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29479832/osteoporosis-in-chronic-liver-disease
#15
Núria Guañabens, Albert Parés
Osteoporosis is a frequent complication in patients with chronic liver disease, especially in end-stages and in chronic cholestasis, in addition to nonalcoholic fatty liver disease, hemochromatosis and alcoholism. Mechanisms underlying osteoporosis are poorly understood, but osteoporosis mainly results from low bone formation. In this setting, sclerostin, a key regulator of the Wnt/ß-catenin signalling pathway which regulates bone formation, in addition to the effects of the retained substances of cholestasis such as bilirubin and bile acids on osteoblastic cells, may influence the decreased bone formation in chronic cholestasis...
February 26, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29467386/bmi-reduction-and-vitamin-d-insufficiency-mediated-osteoporosis-and-fragility-fractures-in-patients-at-nutritional-risk-a-cross-sectional-study
#16
Yatong Li, Min Hui, Xiao Chang, Mei Li, Yipeng Wang, Baozhong Zhang, Jianchun Yu
It seemed to be common sense that malnutrition was associated with osteoporosis, but there were few studies with detailed data proving that. Additionally, the association between BMI and osteoporosis was still under discussion. In our study of 138 patients, we first confirmed the association between nutrition and osteoporosis with propensity score matching method reducing the confounding bias, then discovered that body mass index (BMI) and 25OHD level acted as two crucial factors of nutrition risk-mediated osteoporosis...
February 21, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29463015/association-between-bone-mineral-density-of-femoral-neck-and-geriatric-nutritional-risk-index-in-rheumatoid-arthritis-patients-treated-with-biological-disease-modifying-anti-rheumatic-drugs
#17
Hiroto Tokumoto, Hiroyuki Tominaga, Yoshiya Arishima, Go Jokoji, Masaki Akimoto, Hideo Ohtsubo, Eiji Taketomi, Nobuhiko Sunahara, Satoshi Nagano, Yasuhiro Ishidou, Setsuro Komiya, Takao Setoguchi
Treatment of rheumatoid arthritis (RA) with biological disease-modifying anti-rheumatic drugs (bDMARDs) induces rapid remission. However, osteoporosis and its management remains a problem. The Geriatric Nutritional Risk Index (GNRI) evaluates the risk of malnutrition-related complications in elderly patients and has been shown to be a significant predictor of many diseases. We evaluated the correlation between GNRI and RA activity. In addition, risk factors for femoral neck bone loss were evaluated in RA patients treated with bDMARDs...
February 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29461563/external-skeletal-robusticity-of-children-and-adolescents-european-references-from-birth-to-adulthood-and-international-comparisons
#18
Rebekka Mumm, Elena Godina, Slawomir Koziel, Martin Musalek, Petr Sedlak, Ursula Wittwer-Backofen, Volker Hesse, Parasmani Dasgupta, Maciej Henneberg, Christiane Scheffler
Background: In our modern world, the way of life in nutritional and activity behaviour has changed. As a consequence, parallel trends of an epidemic of overweight and a decline in external skeletal robusticity are observed in children and adolescents. Aim: We aim to develop reference centiles for external skeletal robusticity of European girls and boys aged 0 to 18 years using the Frame Index as an indicator and identify population specific age-related patterns. Methods: We analysed cross-sectional & longitudinal data on body height and elbow breadth of boys and girls from Europe (0-18 years, n = 41...
February 20, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29445830/bone-health-assessment-in-older-people-with-or-without-muscle-health-impairment
#19
M Locquet, C Beaudart, O Bruyère, J A Kanis, L Delandsheere, J-Y Reginster
This study investigated the relationship between muscle and bone status in elderly individuals. Our results suggested links between sarcopenia and osteoporosis; impairment in muscle status (i.e., muscle mass, muscle strength, and physical performance) is associated with deterioration in bone mass and texture subsequently leading to an increased risk of fracture. INTRODUCTION: Accumulating evidence has shown associations between sarcopenia and osteoporosis, but existing studies face inconsistencies in the clinical definition of both conditions...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29439738/dietary-inflammatory-index-a-potent-association-with-cardiovascular-risk-factors-among-patients-candidate-for-coronary-artery-bypass-grafting-cabg-surgery
#20
Mahdieh Abbasalizad Farhangi, Mahdi Najafi
BACKGROUND: Recently, the clinical importance of dietary inflammatory index (DII) in predicting the inflammatory potential of diet and its role in pathogenesis of several chronic disease including some types of cancers, osteoporosis, cardiovascular disease and renal disease has been proposed. However, its association with the disease severity and progression and cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet...
February 13, 2018: Nutrition Journal
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