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https://www.readbyqxmd.com/read/28435477/acrodermatitis-enteropathica-in-a-pair-of-twins
#1
Abdullatif Al Rashed, Mohja Al Shehri, Feroze Kaliyadan
BACKGROUND: Acrodermatitis enteropathica (AE) is a rare autosomal recessive metabolic disorder. First described by Brandt in 1936 and was named by Danbolt. A mutation in the SLC39A4 gene on chromosome 8 q24.3 is responsible for this disorder, which encodes zinc transporter Zip4. The diagnosis is made by the clinical presentation and histopathology and laboratory tests. In this case, we reported a twin presented with a typical rash and low zinc level. To our knowledge, very few cases reported as a twin with typical acrodermatitis enteropathica presentation...
December 31, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28433098/wilson-disease-in-children
#2
Eve A Roberts, Piotr Socha
Wilson disease (WD) is an inherited disorder mainly of hepatocellular copper disposition, due to dysfunction of the Wilson ATPase, a P1B-ATPase encoded by the gene ATP7B. In children, as in older age brackets, clinical disease is highly diverse. Although hepatic disease is the common presentation in children/adolescents, neurologic, psychiatric, and hematologic clinical presentations do occur. Very young children may have clinically evident liver disease due to WD. Early diagnosis, preferably when the child/adolescent is asymptomatic, is most likely to result in near-normal longevity with generally good health so long as the patient tolerates effective medication, is adherent to the lifelong treatment regimen, and has consistent access to the medication...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28426828/consumption-of-fortified-infant-foods-reduces-dietary-diversity-but-has-a-positive-effect-on-subsequent-growth-in-infants-from-sumedang-district-indonesia
#3
Aly Diana, Simonette R Mallard, Jillian J Haszard, Dwi Monik Purnamasari, Ikrimah Nurulazmi, Pratami D Herliani, Gaga I Nugraha, Rosalind S Gibson, Lisa Houghton
Stunting and underweight among under-five children in Indonesia are common, raising public health concerns. Whether inappropriate complementary feeding (CF) practices compromise optimal growth during late infancy in Indonesia is uncertain. Therefore we characterized and evaluated CF practices in Indonesian infants and investigated their relationship with subsequent growth. We enrolled breastfed infants at 6 months of age (n = 230); and followed them at 9 (n = 202) and 12 months of age (n = 190). We collected socio-demographic and anthropometric data and two-day in-home weighed food records...
2017: PloS One
https://www.readbyqxmd.com/read/28425258/assessment-of-developmental-and-radiological-long-term-outcomeof-children-with-surgically-treated-midgut-volvulus
#4
Ahmet Murat Çakmak, Özlem Boybeyi Türer, Gülnur Göllü Bahadir, Bilge Türedi, Ufuk Ateş, Adalet Elçin Yildiz, Gönül Küçük, Ömer Suat Fitöz, Betül Ulukol, Mustafa Kemal Aslan, Tutku Soyer, Hüseyin Dindar
BACKGROUND/AIM: The aim is to evaluate the long-term outcome of asymptomatic patients who underwent surgical correction for midgut volvulus. MATERIALS AND METHODS: Seven patients managed surgically for midgut volvulus in the last 3 years were included. Demographic features, symptoms at presentation, diagnoses, surgical procedures, and complications were recorded. Patients were then contacted for follow-up and evaluation of long-term outcomes. General physical conditions, anthropometric parameters, feeding habits, and defecation histories were evaluated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28420205/do-chinese-children-get-enough-micronutrients
#5
Huijun Wang, Dantong Wang, Yifei Ouyang, Feifei Huang, Gangqiang Ding, Bing Zhang
The aim of this study was to examine usual daily micronutrient intake of Chinese children based on data from the 2011 China Health and Nutrition Survey. We analyzed data from 4 to 17-year-old participants, who provided dietary data on three consecutive days combined with the household weighing method in 2011. Usual daily intake of each nutrient was estimated using a mixed effects model based on the China Food Composition published in 2009. The means, medians and percentages below Estimated Average Requirements (EAR) were reported for selected micronutrients, including calcium, sodium, potassium, iron, zinc, selenium, vitamin A, thiamine, riboflavin and vitamin C...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28399577/drug-development-concepts-as-guides-for-optimizing-clinical-trials-of-supplemental-zinc-for-populations-at-risk-of-deficiency-or-diarrhea
#6
David H Alpers, Graeme P Young, Cuong D Tran, Elissa K Mortimer, Geetha L Gopalsamy, Nancy F Krebs, Mark J Manary, Balakrishnan S Ramakrishna, Henry J Binder, Ian L Brown, Leland V Miller
Studies on the efficacy of zinc supplementation for treatment or prevention of diarrhea have shown an inconsistent effect in populations at risk for zinc deficiency. Unlike drugs, which have no preexisting presence in the body, endogenous zinc must be assessed pharmacokinetically by isotope tracer studies. Although such methods have produced much data, very few studies have estimated the dose and the timing of dosing of zinc supplementation. This review examines drug kinetics used to establish the best dose, the timing of such doses, and the mechanism of action through pharmacodynamic markers and applies them, where possible, to zinc supplements...
March 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28389892/in-silico-identification-and-validation-of-a-novel-hypothetical-protein-in-cryptosporidium-hominis-and-virtual-screening-of-inhibitors-as-therapeutics
#7
Arpit Kumar Shrivastava, Subrat Kumar, Priyadarshi Soumyaranjan Sahu, Rajani Kanta Mahapatra
Computational approaches to predict structure/function and other biological characteristics of proteins are becoming more common in comparison to the traditional methods in drug discovery. Cryptosporidiosis is a major zoonotic diarrheal disease particularly in children, which is caused primarily by Cryptosporidium hominis and Cryptosporidium parvum. Currently, there are no vaccines for cryptosporidiosis and recommended drugs are ineffective. With the availability of complete genome sequence of C. hominis, new targets have been recognized for the development of effective and better drugs and/or vaccines...
April 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28388722/thyroid-and-islet-autoantibodies-predict-autoimmune-thyroid-disease-at-type-1-diabetes-diagnosis
#8
Berglind Jonsdottir, Christer Larsson, Annelie Carlsson, Gun Forsander, Sten Anders Ivarsson, Åke Lernmark, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Eva Örtqvist, Helena Elding Larsson
Context: Screening of autoimmune thyroid disease in children with type 1 diabetes is important but varies between clinics. Objective: To determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA-DQ at diagnosis of type 1 diabetes for autoimmune thyroid disease during follow-up. Setting: Forty-three Swedish pediatric endocrinology units. Design, Patients, and Main Outcome Measures: At diagnosis of type 1 diabetes, autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin, insulinoma-associated protein-2, and 3 variants of zinc transporter 8 (ZnT8W/R/QA) HLA-DQA1-B1 genotypes and thyroid function were analyzed in 2433 children...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28376916/utilization-of-health-facilities-and-predictors-of-health-seeking-behavior-for-under-five-children-with-acute-diarrhea-in-slums-of-addis-ababa-ethiopia-a-community-based-cross-sectional-study
#9
Metadel Adane, Bezatu Mengistie, Worku Mulat, Helmut Kloos, Girmay Medhin
BACKGROUND: Information on health-seeking behavior and utilization of health facilities in slums of Addis Ababa is scarce, impeding the implementation of effective interventions. The purpose of this study is to assess the status of health facilities utilization and predictors for health-seeking behavior of mothers/caregivers of under-five children with acute diarrhea in slums of Addis Ababa, Ethiopia. METHODS: A community-based cross-sectional study design was employed in five rounds of surveys in seven kebeles in slums of Addis Ababa among 472 mothers/caregivers of 472 under-five children with acute diarrhea in reference to Andersen's behavioral model...
April 4, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28359210/trends-in-iron-zinc-and-vitamin-a-status-biomarkers-among-colombian-children
#10
Wenchao Li, Oscar F Herrán, Eduardo Villamor
BACKGROUND: Micronutrient deficiencies are still highly prevalent in countries undergoing the nutrition transition, but nationally representative data documenting their burden in children are exceedingly rare. OBJECTIVE: To examine the distribution and recent trends in micronutrient status biomarkers of Colombian children. METHODS: We compared the distributions of plasma ferritin, serum zinc, and vitamin A in Colombian children between 2005 and 2010 using 2 cross-sectional, nationally representative surveys overall and by categories of sociodemographic variables...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28346055/a-to-i-editing-in-disease-is-not-fake-news
#11
Prajakta Bajad, Michael F Jantsch, Liam Keegan, Mary O'Connell
Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited with up to one hundred percent efficiency, leading to the production of alternative protein variants. However, the majority of editing events occur within longer stretches of dsRNA formed by pairing of repetitive sequences. Here, many different adenosine bases are potential targets but editing efficiency is usually much lower...
March 27, 2017: RNA Biology
https://www.readbyqxmd.com/read/28345660/zinc-deficiency-and-low-enterocyte-zinc-transporter-expression-in-human-patients-with-autism-related-mutations-in-shank3
#12
Stefanie Pfaender, Ann Katrin Sauer, Simone Hagmeyer, Katharina Mangus, Leonhard Linta, Stefan Liebau, Juergen Bockmann, Guillaume Huguet, Thomas Bourgeron, Tobias M Boeckers, Andreas M Grabrucker
Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic children, we have previously reported high incidence of Zn deficiency in PMDS. However, the underlying mechanisms are currently not well understood. Here, using inductively coupled plasma mass-spectrometry to measure the concentration of Zinc (Zn) and Copper (Cu) in hair samples from individuals with PMDS with 22q13.3 deletion including SHANK3 (SH3 and multiple ankyrin repeat domains 3), we report a high rate of abnormally low Zn/Cu ratios...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28343659/iron-and-zinc-supplementation-does-not-impact-urinary-arsenic-excretion-in-mexican-school-children
#13
Katarzyna Kordas, Aditi Roy, Patricia López, Gonzalo García-Vargas, Mariano E Cebrián, Eunice Vera-Aguilar, Jorge L Rosado
OBJECTIVE: To examine the role of iron and zinc in arsenic excretion and metabolism in children. STUDY DESIGN: An analysis of urinary arsenic (UAs) concentrations from a double-blind randomized trial originally testing the efficacy of iron and zinc for lowering blood lead levels in children. A 2 × 2 factorial design was used, with children randomized individually, stratified by sex and classroom, to receive 30 mg ferrous fumarate (n = 148), 30 mg zinc oxide (n = 144), iron and zinc together (n = 148), or placebo (n = 151)...
March 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28298275/the-impact-of-nutritional-interventions-beyond-the-first-2-years-of-life-on-linear-growth-a-systematic-review-and-meta-analysis
#14
REVIEW
Joseph L Roberts, Aryeh D Stein
A large body of evidence suggests that the first 1000 d from conception is a critical window in which interventions to address malnutrition will be most effective, but little is known about the impact on linear growth of nutritional interventions in children ≥2 y of age. The aim of this analysis was to evaluate the effectiveness of several nutrition-based interventions, specifically iron, zinc, calcium, iodine, vitamin A, multiple (≥2) micronutrients, protein, and food, at improving growth in children ≥2 y of age...
March 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28283951/relationships-between-element-contents-in-polish-children-s-and-adolescents-hair
#15
Maria Długaszek, Wojciech Skrzeczanowski
Environment, sex, and age are the main factors which determine the elemental composition of hair. The objective of the study is to determine the contents of calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in girls' and boys' hair in five age groups (within 1-19-year range) corresponding to successive human ontogenesis phases as well as to evaluate the relationships between these elements. Quantitative analysis has been carried out using atomic absorption spectrometry (AAS)...
March 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28271631/simulated-effects-of-home-fortification-of-complementary-foods-with-micronutrient-powders-on-risk-of-inadequate-and-excessive-intakes-in-west-gojjam-ethiopia
#16
Zeweter Abebe, Gulelat Desse Haki, Kaleab Baye
Home fortification of complementary foods (CFs) with multiple micronutrient powders (MNPs) is being scaled up in various countries, but little is known about the prevailing complementary feeding practices and the type and nutrient gaps to be filled with MNPs. The present study evaluated the complementary feeding practices of young children and simulated the risk of inadequate and excessive intakes associated with home fortification with MNPs. We have assessed the sociodemographic status, anthropometry, and complementary feeding practices of young children (N = 122) in Mecha district, rural Ethiopia...
March 8, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28261556/relationships-between-dietary-intake-and-cognitive-function-in-healthy-korean-children-and-adolescents
#17
Jin Young Kim, Seung Wan Kang
BACKGROUND: It has long been theorized that a relatively robust dietary intake impacts cognitive function. The aim of the study was to explore dietary intake and cognitive function in healthy Korean children and adolescents. METHODS: Three hundred and seventeen healthy children with no previous diagnosis of neurologic or psychiatric disorders were evaluated (167 girls and 150 boys with a mean age of 11.8 ± 3.3 years). Analysis indicators including food frequency questionnaires (FFQs) consisting of 76 items and neurocognitive tests including symbol digit modalities (SDMT), verbal memory, visual memory, shift attention, reasoning, and digit span (forward and backward) tests were observed and recorded...
January 2017: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/28251481/hair-zinc-and-severity-of-symptoms-are-increased-in-children-with-attention-deficit-and-hyperactivity-disorder-a-hair-multi-element-profile-study
#18
Torsak Tippairote, Piya Temviriyanukul, Wenika Benjapong, Dunyaporn Trachootham
Determination of bioelement levels in hair is an emerging non-invasive approach for screening bioelement deposition. However, the role of essential bioelement levels in hair and attention deficit/hyperactivity disorder (ADHD) risk or severity is largely unknown. In this study, we have compared multi-element hair profiles between healthy and ADHD Thai children. In addition, the correlations between bioelements and ADHD symptoms according to Diagnostic and Statistical Manual of Mental Disorders, 5th edition, diagnostic criteria were identified...
March 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28244709/diet-quality-and-eating-behavioural-patterns-in-preschool-children-in-hong-kong
#19
Pui-Sze Yip, Vivian Wai-Yen Chan, Queenie Kwan-Yee Lee, Hang-Mei Lee
BACKGROUND AND OBJECTIVES: To assess the diet quality and eating behaviour of preschool children, investigate parents' feeding practices, and obtain information on the kindergarten nutrition environment of Hong Kong children aged 30-60 months. METHODS AND STUDY DESIGN: Dietary information was obtained using multiple 24-hour recalls. Questionnaires were developed to obtain information on children' seating behaviour, parents' feeding practices and preschool nutrition environment...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28239540/differences-in-preschool-age-children-s-dietary-intake-between-meals-consumed-at-childcare-and-at-home
#20
S B Sisson, A C Kiger, K C Anundson, A H Rasbold, M Krampe, J Campbell, B DeGrace, L Hoffman
Preschool children need optimal nutrition, including a variety of nutrient-dense foods, for growth and development. The purpose of this study was to determine differences in foods and nutrients consumed at childcare and home environments. Children ages 3-to-5 years (n = 90, 3.8 ± 0.7 years; 56% female) from 16 childcare centers participated in this cross-sectional study from 2011 to 2014. Lunches at childcare were observed for two days; three days of dinners at home were reported by caregivers. Nutrient-dense and energy-dense foods were counted and nutrient content of meals was determined using FoodWorks®...
June 2017: Preventive Medicine Reports
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