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https://www.readbyqxmd.com/read/28225210/prophylactic-drug-management-for-febrile-seizures-in-children
#1
REVIEW
Martin Offringa, Richard Newton, Martinus A Cozijnsen, Sarah J Nevitt
BACKGROUND: Febrile seizures occurring in a child older than one month during an episode of fever affect 2% to 4% of children in Great Britain and the United States and recur in 30%. Rapid-acting antiepileptics and antipyretics given during subsequent fever episodes have been used to avoid the adverse effects of continuous antiepileptic drugs. OBJECTIVES: To evaluate primarily the effectiveness and safety of antiepileptic and antipyretic drugs used prophylactically to treat children with febrile seizures; but also to evaluate any other drug intervention where there was a sound biological rationale for its use...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28222184/ecological-and-human-health-risks-associated-with-abandoned-gold-mine-tailings-contaminated-soil
#2
Veronica Mpode Ngole-Jeme, Peter Fantke
Gold mining is a major source of metal and metalloid emissions into the environment. Studies were carried out in Krugersdorp, South Africa, to evaluate the ecological and human health risks associated with exposure to metals and metalloids in mine tailings contaminated soils. Concentrations of arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and zinc (Zn) in soil samples from the area varied with the highest contamination factors (expressed as ratio of metal or metalloid concentration in the tailings contaminated soil to that of the control site) observed for As (3...
2017: PloS One
https://www.readbyqxmd.com/read/28212474/-zinc-phosphide-poisoning-in-pediatric-patients-from-a-toxicology-center-at-mexico-city
#3
María Carmen Socorro Sánchez-Villegas, Alejandro Bárcena-Ruiz
BACKGROUND: Zinc phosphide is a chemical compound that is frequently used as a rodenticide; it is a highly toxic product that is widely used, among other spaces, at home. Given that it is a highly commercialized pesticide and that there is no antidote, it is mandatory to establish favorably the clinical manifestations of the intoxication. The aim was to describe the epidemiological and clinical profile of children intoxicated with zinc phosphide attended in a toxicological center of a tertiary referral hospital...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28208814/adequacy-of-usual-vitamin-and-mineral-intake-in-spanish-children-and-adolescents-enalia-study
#4
Ana M López-Sobaler, Aránzazu Aparicio, Liliana G González-Rodríguez, Esther Cuadrado-Soto, Josefa Rubio, Victoria Marcos, Rosa Sanchidrián, Sara Santos, Napoleón Pérez-Farinós, Marian Ángeles Dal Re, Carmen Villar, Teresa Robledo, J Javier Castrodeza, Rosa M Ortega
Background: The National Dietary Survey on the Child and Adolescent Population in Spain (ENALIA) provides data to assess the usual micronutrient intake among Spanish infants, children, and adolescents. Methods: Cross-sectional survey (November 2012-July 2014) of a representative sample of Spanish children and adolescents (six months-17 years) (n = 1862). Dietary information was collected using two non-consecutive one-day food diaries (six months-10 years old) or two 24 h dietary recalls (11 years and older) separated by at least 14 days...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28207797/mutation-increasing-%C3%AE-carotene-concentrations-does-not-adversely-affect-concentrations-of-essential-mineral-elements-in-pepper-fruit
#5
Nasya B Tomlekova, Philip J White, Jacqueline A Thompson, Emil A Penchev, Stephan Nielen
Vitamin and mineral deficiencies are prevalent in human populations throughout the world. Vitamin A deficiency affects hundreds of millions of pre-school age children in low income countries. Fruits of pepper (Capsicum annuum L.) can be a major dietary source of precursors to Vitamin A biosynthesis, such as β-carotene. Recently, pepper breeding programs have introduced the orange-fruited (of) trait of the mutant variety Oranzheva kapiya, which is associated with high fruit β-carotene concentrations, to the mutant variety Albena...
2017: PloS One
https://www.readbyqxmd.com/read/28205320/trace-elements-in-children-suffering-from-sickle-cell-anemia-a%C3%A2-case-control-study
#6
Joseph K Sungu, Olivier Mukuku, Augustin Mulangu Mutombo, Paul Mawaw, Michel N Aloni, Oscar N Luboya
BACKGROUND: Information on serum albumin and trace elements among children suffering from Sickle Cell Anemia (SCA) was poorly documented in Africa. The aim of this study was to describe and to compare different values of trace elements with published reports from other parts of the world. METHODS: We carried out a case-control study. Seventy-six steady state children suffering from SCA (Hb-SS). One hundred and fifty-two children were recruited with 76 (cases, Hb-SS) and 76 (control, Hb-AA) to compare the data...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28168597/the-role-of-nutritional-supplements-in-the-treatment-of-adhd-what-the-evidence-says
#7
REVIEW
Klaus W Lange, Joachim Hauser, Katharina M Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Yuko Sakaue, Tomoyuki Takano, Yoshihiro Takeuchi
Attention-deficit hyperactivity disorder (ADHD) is a common behavioral disorder in children and adolescents and may persist into adulthood. Insufficient nutritional supply of long-chain polyunsaturated fatty acids (LC-PUFAs) and other components including various minerals has been suggested to play a role in the development of ADHD symptoms. This review presents the evidence regarding the role of nutritional PUFA, zinc, iron, and magnesium supplements in the treatment of ADHD with a focus on the critical evaluation of the relevant literature published from 2014 to April 2016...
February 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28165362/relationship-between-selected-serum-metallic-elements-and-obesity-in-children-and-adolescent-in-the-u-s
#8
Yun Fan, Chunlan Zhang, Jin Bu
The prevalence of obesity has increased at an alarming rate worldwide. Metallic elements are involved in the pathogenesis of obesity and related diseases. To date, whether environmental exposure to metallic elements has effects on obesity in children and adolescents is still unclear. The aim of the current study was to investigate the association of blood metallic elements with obesity in U.S. children and adolescents. This cross-sectional study was performed with 5404 children and adolescents (6-19 years, 2745 males and 2659 females) who participated in the US National Health and Nutrition Examination Survey 2011-2014...
February 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28154759/diarrhea-no-more-does-zinc-help-the-poor-evidence-on-the-effectiveness-of-programmatic-efforts-to-reach-poorest-in-delivering-zinc-and-ors-at-scale-in-up-and-gujarat-india
#9
Amnesty E LeFevre, Diwakar Mohan, Sarmila Mazumder, Laura L Lamberti, Sunita Taneja, Robert E Black, Christa L Fischer-Walker
BACKGROUND: India has the greatest burden of diarrhea in children under 5 years globally. The Diarrhea Alleviation through zinc and oral rehydration salts (ORS) Therapy program (2010-2014) sought to improve access to and utilization of zinc and ORS among children 2-59 months in Gujarat and Uttar Pradesh (UP), India, through public and private sector delivery channels. In this analysis, we present findings on program's effect in reducing child-health inequities. METHODS: Data from cross-sectional baseline and endline surveys were used to assess disparities in key outcomes across six dimensions: socioeconomic strata, gender, caregiver education, ethnicity and geography...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/28152989/small-quantity-lipid-based-nutrient-supplements-containing-different-amounts-of-zinc-along-with-diarrhea-and-malaria-treatment-increase-iron-and-vitamin-a-status-and-reduce-anemia-prevalence-but-do-not-affect-zinc-status-in-young-burkinabe-children-a-cluster
#10
Souheila Abbeddou, Elizabeth Yakes Jimenez, Jérome W Somé, Jean Bosco Ouédraogo, Kenneth H Brown, Sonja Y Hess
BACKGROUND: We assessed the effects of providing a package of interventions including small-quantity lipid-based nutrient supplements (SQ-LNS) containing 0, 5 or 10 mg zinc and illness treatment to Burkinabe children from 9 to 18 months of age, on biomarkers of zinc, iron and vitamin A status at 18 months and compared with a non-intervention cohort (NIC). METHODS: Using a two-stage cluster randomized trial design, communities were randomly assigned to the intervention cohort (IC) or NIC, and extended family compounds within the IC were randomly assigned to different treatment groups...
February 2, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28150350/nutrient-intakes-and-compliance-with-nutrient-recommendations-in-children-aged-1-4-years-in-ireland
#11
J Walton, L Kehoe, B A McNulty, A P Nugent, A Flynn
BACKGROUND: The early childhood years represent a period of rapid growth and development characterised by unique requirements for energy and individual nutrients. METHODS: The present study uses data from the National Pre-School Nutrition Survey, a nationally representative sample of Irish children (1-4 years) (n = 500), aiming to estimate energy and nutrient intakes across age and compliance with recommendations (UK and European). A 4-day weighed food-record was used to collect dietary data and statistical modelling (National Cancer Institute method) was applied to estimate usual nutrient intakes...
February 2, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28138163/comparison-of-the-effectiveness-of-zinc-supplementation-in-tablets-form-with-that-of-the-suspension-form-in-the-treatment-of-acute-diarrhoea
#12
Sarwat Urooj, Hafeez Ullah Memon, Yasmeen Memon, Bibi Shazia Ali
OBJECTIVE: To compare the effectiveness of zinc supplementation in tablet form with that of the suspension form in the treatment of acute diarrhoea. METHODS: A comparative study was carried out at the Liaquat University Hospital, Hyderabad, Pakistan from October 2008 to April 2009, and comprised children aged6-24 months suffering from acute diarrhoea. The patients were divided into two groups on the basis of even and odd numbers. Group A (even numbers) received dispersible zinc tablets, and group B (odd numbers) received zinc suspension...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28123772/racecadotril-for-the-treatment-of-severe-acute-watery-diarrhoea-in-children-admitted-to-a-tertiary-hospital-in-kenya
#13
Jaspreet Gharial, Ahmed Laving, Fred Were
BACKGROUND: Diarrhoea is the second most common cause of death in children under 5 years of age in Kenya. It is usually treated with oral rehydration, zinc and continued feeding. Racecadotril has been in use for over 2 decades; however, there is a paucity of data regarding its efficacy from Africa. OBJECTIVES: The objectives of this study were: to compare the number of stools in the first 48 hours in children with severe gastroenteritis requiring admission and treated with either racecadotril or placebo, to study the impact of racecadotril on duration of inpatient stay as well as duration of diarrhoea and to describe the side effect profile of racecadotril...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28123507/inhibition-of-the-cyclind1-promoter-in-response-to-sonic-hedgehog-signaling-pathway-transduction-is-mediated-by-gli1
#14
Zhongxiao Lin, Hansong Sheng, Chaoguo You, Ming Cai, Yiping Zhang, Li Sheng Yu, Xiaoming Yu, Jian Lin, Nu Zhang
Medulloblastoma (MB) is the most common malignant tumor of the central nervous system in children. Accumulating evidence suggests a major role for the activation of the sonic hedgehog (SHH) signaling pathway in the development of MB cells; however, the mechanisms underlying the effect of this pathway on tumor survival and growth remain poorly understood. The Gli family zinc finger 1 (Gli1) transcription factor is considered as a mediator of the SHH signaling pathway in MB cells. Therefore, the present study investigated whether the SHH signaling pathway promotes the apoptosis of MB cells via downregulation of Gli1...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28118832/in-vitro-screening-for-antiviral-activity-of-turkish-plants-revealing-methanolic-extract-of-rindera-lanata-var-lanata-active-against-human-rotavirus
#15
Andrea Civra, Rachele Francese, Davide Sinato, Manuela Donalisio, Valeria Cagno, Patrizia Rubiolo, Ramazan Ceylan, Ahmet Uysal, Gokhan Zengin, David Lembo
BACKGROUND: Human rotavirus (HRoV) is the leading cause of severe gastroenteritis in infants and children under the age of five years. No specific antiviral drug is available for HRoV infections and the treatment of viral diarrhea is mainly based on rehydration and zinc treatment. In this study, we explored medicinal plants endemic to Turkey flora as a source of anti-HRoV compunds. METHODS: We performed an antiviral screening on Ballota macrodonta, Salvia cryptantha and Rindera lanata extracts by focus reduction assay...
January 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28118744/national-risk-of-zinc-deficiency-as-estimated-by-national-surveys
#16
Sonja Y Hess
BACKGROUND: Information is needed on the national prevalence of zinc deficiency to guide program development and evaluation. OBJECTIVE: To summarize results of national surveys that assessed plasma or serum zinc concentrations (PZC) and compare the prevalence of low PZC with other methods used to estimate countries' risk of zinc deficiency. METHODS: National surveys that included PZC were identified through Internet searches and personal contacts...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28115775/vacuum-impregnation-a-promising-way-for-mineral-fortification-in-potato-porous-matrix-potato-chips
#17
Alka Joshi, A Kar, S G Rudra, V R Sagar, E Varghese, M Lad, I Khan, B Singh
Potato chips can be considered as an ideal carrier for targeted nutrient/s delivery as mostly consumed by the vulnerable group (children and teen agers). The present study was planned to fortifiy potato chips with calcium (Calcium lactate) and zinc (Zinc sulphate) using vacuum impregnation technique. At about 70-80 mm Hg vacuum pressure, maximum level of impregnation of both the minerals was achieved. Results showed that after optimization, calcium lactate at 4.81%, zinc sulphate at 0.72%, and vacuum of 33...
December 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28110159/manganese-intake-is-inversely-associated-with-depressive-symptoms-during-pregnancy-in-japan-baseline-data-from-the-kyushu-okinawa-maternal-and-child-health-study
#18
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa
BACKGROUND: One epidemiological study in Canada has addressed the association between zinc intake and depressive symptoms during pregnancy while another epidemiological study in Korea has examined the association between iron intake and depressive symptoms during pregnancy. The present cross-sectional study in Japan examined the association between intake of zinc, magnesium, iron, copper, and manganese and depressive symptoms during pregnancy. METHODS: Study subjects were 1745 pregnant women...
March 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28104559/distribution-of-heavy-metals-and-metalloids-in-bulk-and-particle-size-fractions-of-soils-from-coal-mine-brownfield-and-implications-on-human-health
#19
Hongxia Li, Hongbing Ji, Chunjing Shi, Yang Gao, Yan Zhang, Xiangyu Xu, Huaijian Ding, Lei Tang, Yuxin Xing
Heavy metals (HMs) and metalloids migrate into their surroundings, thus increasing environmental risks and threatening human health. Current studies on coal-mine brownfields, however, have not thoroughly investigated soil-associated HMs and metalloids produced by coal mining. Therefore, this study explored the spatial and particle fraction distribution and human health implications of HMs and metalloids. The soil-associated HMs and metalloids are Arsenic (As), Cadmium (Cd), Chromium (Cr), Copper (Cu), Mercury (Hg), Manganese (Mn), Nickel (Ni), Lead (Pb), Scandium (Sc), Titanium (Ti) and Zinc (Zn)...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28103915/effects-of-community-health-volunteers-on-infectious-diseases-of-children-under-five-in-volta-region-ghana-study-protocol-for-a-cluster-randomized-controlled-trial
#20
Yeonji Ma, Heunghee Kim, Yinseo Cho, Jaeeun Lee, Joseph Kwami Degley, Abdul-Ghaffa Adam, Gyuhong Lee, Hoonsang Lee, Seungman Cha
BACKGROUND: In many low- and middle-income countries, community health volunteers (CHVs) are employed as a key element of the public health system in rural areas with poor accessibility. However, few studies have assessed the effectiveness of CHVs in improving child health in sub-Saharan Africa through randomized controlled trials. The present study aims to measure the impact of health promotion and case management implemented by CHVs on the health of under-5 children in Ghana. METHODS/DESIGN: This study presents the protocol of a cluster-randomized controlled trial assessing the impacts of CHVs, in which the community was used as the randomization unit...
January 19, 2017: BMC Public Health
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