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https://www.readbyqxmd.com/read/29763354/randomized-controlled-trial-of-pulpotomy-in-primary-molars-using-mta-and-formocresol-compared-to-3mixtatin-a-novel-biomaterial
#1
Zahra Jamali, Vajiheh Alavi, Ebrahim Najafpour, Naser Asl Aminabadi, Sajjad Shirazi
OBJECTIVE: This study was conducted to compare the efficacy of 3Mixtatin (a combination of simvastatin and 3Mix antibiotic) with MTA and Formocresol for the pulpotomy of primary molars. STUDY DESIGN: 114 children aged 3-6 years old with 150 primary molars were randomly allocated to three groups. MTA, Formocresol or 3Mixtatin were used for Pulpotomies. Hard setting zinc oxide eugenol was used to cover these materials. The teeth were restored with amalgam. Blinded radiographic and clinical examinations were conducted at 6, 12 and 24 months after treatment for the presence of pain, tenderness to palpation and percussion, sinus tract, swelling, presence of internal or external root resorption, inter-radicular radiolucency, and periapical lesion...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29749445/knockdown-of-zinc-transporter-zip8-expression-inhibits-neuroblastoma-progression-and-metastasis-in-vitro
#2
Zhengrong Mei, Pengke Yan, Ying Wang, Shaozhi Liu, Fang He
Neuroblastoma is one of the leading causes of cancer‑associated mortality worldwide, particularly in children, partially due to the absence of effective therapeutic targets and diagnostic biomarkers. Therefore, novel molecular targets are critical to the development of therapeutic approaches for neuroblastoma. In the present study, the functions of zinc transporter ZIP8 (Zip8), a member of the zinc transporting protein family, were investigated as novel molecular targets in neuroblastoma cancer cells. The proliferation rates of neuroblastoma cancer cells were significantly decreased when Zip8 was knocked down by lentiviral‑mediated RNA interference...
May 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29724127/growth-components-of-cow-s-milk-emphasis-on-effects-in-undernourished-children
#3
Benedikte Grenov, Kim F Michaelsen
BACKGROUND: Cow's milk is a core ingredient in foods for prevention and treatment of undernutrition in children. It promotes growth, but there is limited knowledge of which components in milk have growth-stimulating effects. OBJECTIVE: To discuss the growth-stimulating effects of milk in undernourished children with emphasis on protein, lactose, and minerals. METHODS: We reviewed literature on dairy and growth in undernourished children. RESULTS: Cow's milk has a specific stimulating effect on linear growth, even in well-nourished children, and it may stimulate weight gain and muscle accretion in wasted children...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29720136/prevalence-and-predictors-of-under-nutrition-among-school-children-in-a-rural-south-eastern-nigerian-community-a-cross-sectional-study
#4
Rufina N B Ayogu, Ifeoma C Afiaenyi, Edith U Madukwe, Elizabeth A Udenta
BACKGROUND: School children in developing countries like Nigeria are faced with numerous nutrition and health problems. Lack of functional school health and nutrition programmes in Enugu state, Nigeria may be associated with dearth of data on associated factors. Identifying these factors could inform the design and implementation of school-based programmes aimed at ameliorating these problems. METHODS: A cross sectional survey involving 450 primary and secondary school children aged 6-15 years was conducted in Ede-Oballa, a rural community in Enugu state, South-eastern Nigeria...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29714159/burden-and-risk-factors-of-antimicrobial-use-in-under-five-children-with-diarrheal-illness-in-rural-bangladesh
#5
Shahnawaz Ahmed, Poonum Korpe, Tahmeed Ahmed, Mohammod Jobayer Chisti, Abu Syed Golam Faruque
Antimicrobial overuse contributes to antimicrobial resistance. Empiric use of antimicrobials for diarrheal illness is warranted only in a minority of cases, because of its self-limiting nature and multifactorial etiology. This study aims to describe the factors contributing to antimicrobial overuse for diarrheal disease among children less than 5 years of age in rural Bangladesh. A total of 3,570 under-five children presenting with diarrhea in a tertiary level hospital were enrolled in the study. The rate of antimicrobial use at home was 1,395 (39%), compared with 2,084 (89%) during a hospital visit...
April 30, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29713463/zinc-as-an-adjunct-therapy-in-the-management-of-severe-pneumonia-among-gambian-children-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Stephen Howie, Christian Bottomley, Osaretin Chimah, Readon Ideh, Bernard Ebruke, Uduak Okomo, Charles Onyeama, Simon Donkor, Onike Rodrigues, Mary Tapgun, Marie Janneh, Claire Oluwalana, Bankole Kuti, Godwin Enwere, Pamela Esangbedo, Conor Doherty, Grant Mackenzie, Brian Greenwood, Tumani Corrah, Andrew Prentice, Richard Adegbola, Syed Zaman
Background: The benefit of zinc as an adjunct therapy for severe pneumonia is not established. We assessed the benefit of adjunct zinc therapy for severe pneumonia in children and determined whether the study children were zinc deficient. Methods: This was a randomized, parallel group, double-blind, placebo-controlled trial with an allocation ratio of 1:1 conducted in children with severe pneumonia to evaluate the efficacy of daily zinc as an adjunct treatment in preventing 'treatment failure' (presence of any sign of severe pneumonia) on day-5 and day-10 and in reducing the time to resolution of signs of severe pneumonia...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29703512/urinary-metal-concentrations-among-mothers-and-children-in-a-mexico-city-birth-cohort-study
#7
Ryan C Lewis, John D Meeker, Niladri Basu, Alison M Gauthier, Alejandra Cantoral, Adriana Mercado-García, Karen E Peterson, Martha Maria Téllez-Rojo, Deborah J Watkins
Personal care product use is a potential source of metals exposure among children, but studies have been limited. We measured urinary concentrations of 10 metals (aluminum, arsenic [As], barium [Ba], cadmium, cobalt [Co], lead [Pb], manganese [Mn], molybdenum [Mo], nickel, and zinc [Zn]) in third trimester pregnant women (n = 212) and their children at 8-14 years of age (n = 250). Demographic factors (child sex, age, socioeconomic status, and maternal education), body mass index (BMI) z-score, and child personal care product use in the 24 h prior to urine collection were examined as predictors of urinary metal concentrations...
April 22, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29697381/-biosubstrates-as-dental-health-indicators-in-school-age-children
#8
T Shishniashvili, N Suladze, M Beridze, N Manjavidze
Lack of essential elements can lead to the development of general and dental diseases. To assess the level of microelements in the human body, the most informative biosubstrates are hair and dental hard tissues, in which the chemical elements are concentrated and fully reflect the quality of essential elements. We examined 34 6-12 years-old children to study the content of essential elements in biosubstrates, as in dental health indicators (in the period of formation and mineralization of most permanent teeth)...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29693403/second-national-integrated-micronutrient-survey-in-iran-study-design-and-preliminary-findings
#9
Hamed Pouraram, Abolghasem Djazayery, Kazem Mohammad, Mahboobeh Parsaeian, Zahra Abdollahi, Ahmadreza Dorosty Motlagh, Mahmoud Djalali, Katayoon Khodaverdian, Gity Sotoudeh, Amirhusein Yarparvar, Ramin Heshmat, Fereydoun Siassi
BACKGROUND: The main objective of the Second National Integrated Micronutrient Survey (NIMS-II) was to assess the nutritional status of four micronutrients, namely iron, zinc, and vitamins A and D, and also to conduct an anthropometric assessment of selected groups of children, adolescents, pregnant women, and adults, disaggregated by sex and residential area in nationally representative samples. This paper reports the design of the study along with preliminary findings. METHODS: In this study, 32 770 individuals were selected by using single-stage cluster sampling...
April 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29692662/changes-in-the-chemical-composition-of-mineralised-teeth-in-children-after-antineoplastic-treatment
#10
Ewa Krasuska-Sławińska, Bożenna Dembowska-Bagińska, Agnieszka Brożyna, Dorota Olczak-Kowalczyk, Elżbieta Czarnowska, Agnieszka Sowińska
Introduction: Chemotherapy, neoplasms, and their complications linked to malabsorption, malnutrition, and metabolic disorders may lead to improper tooth development and frequent severe caries in patients during/after antineoplastic treatment and to a more frequent improper tooth development in patients undergoing chemotherapy during odontogenesis. However, the causes of these abnormalities remain unknown; there are no studies on the impact of antineoplastic treatment and its complications on the chemical composition of mineralised teeth...
2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29684495/carcinogenic-and-non-carcinogenic-health-risks-of-metal-oid-s-in-tap-water-from-ilam-city-iran
#11
Yadolah Fakhri, Narottam Saha, Amir Sheikhmohammadi, Milad Rasouli, Moayed Avazpour, Aziz Rahimizadeh, Seyed-Mohammad Riahi, Mansour Ghaderpoori, Hassan Keramati, Bigard Moradi, Nazak Amanidaz, Zahra Baninameh, Amin Mousavi Khaneghah
One of the most important pathways for exposure to metals is drinking water ingestion. Chronic or acute exposure to metals can endanger the health of the exposed population, and hence, estimation of human health risks is crucial. In the current study for the first time, the concentrations of Mercury (Hg), Arsenic (As), Zinc (Zn), Lead (Pb) and Cobalt (Co) in 120 collected tap water samples (2015, July-November) from Ilam city, Iran were investigated using flame atomic absorption spectrophotometer. Also, the metal-induced carcinogenic and non-carcinogenic risks for consumers exposed to tap drinking water were calculated...
April 20, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29681083/novel-de-novo-zbtb20-mutations-in-three-cases-with-primrose-syndrome-and-constant-corpus-callosum-anomalies
#12
Caroline Alby, Lucile Boutaud, Bettina Bessières, Valérie Serre, Marlene Rio, Valerie Cormier-Daire, Judith de Oliveira, Amale Ichkou, Linda Mouthon, Christopher T Gordon, Maryse Bonnière, Charlotte Mechler, Patrick Nitschke, Christine Bole, Stanislas Lyonnet, Nadia Bahi-Buisson, Nathalie Boddaert, Laurence Colleaux, Philippe Roth, Yves Ville, Michel Vekemans, Féréchté Encha-Razavi, Tania Attié-Bitach, Sophie Thomas
Corpus callosum (CC) is the major brain commissure connecting homologous areas of cerebral hemispheres. CC anomalies (CCAs) are the most frequent brain anomalies leading to variable neurodevelopmental outcomes making genetic counseling difficult in the absence of a known etiology that might inform the prognosis. Here, we used whole exome sequencing, and a targeted capture panel of syndromic CCA known causal and candidate genes to screen a cohort of 64 fetuses with CCA observed upon autopsy, and 34 children with CCA and intellectual disability...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29668570/value-of-serum-zinc-in-diagnosing-and-assessing-severity-of-liver-disease-in-children-with-wilson-disease
#13
Palittiya Sintusek, Eirini Kyrana, Anil Dhawan
Supplemental Digital Content is available in the textABSTRACT OBJECTIVES:: Wilson disease (WD) is a rare inborn error of copper metabolism with diverse manifestations. There has been no study of zinc (Zn), the copper's antagonist, in WD diagnosis and severity so far. Our aims were to evaluate serum Zn in WD and its correlation with the disease severity score (revised WD index). Although the ATP7B mutation analysis is highly accurate for WD diagnosis, it may not be readily available in a resource-limiting setting...
April 17, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29661930/the-critical-role-of-zinc-in-a-new-murine-model-of-enterotoxigenic-e-coli-etec-diarrhea
#14
D T Bolick, P H Q S Medeiros, S E Ledwaba, A A M Lima, J P Nataro, E M Barry, R L Guerrant
Enterotoxigenic E. coli are major causes of traveler's diarrhea as well as endemic diarrhea and stunting in children in developing areas. However a small mammal model has been badly needed to better understand and assess mechanisms, vaccines and interventions. We report a murine model of ETEC diarrhea, weight loss and enteropathy, and investigate the role of zinc on the outcomes. LT+ST producing enterotoxigenic E. coli (ETEC) given to weaned C57BL/6 mice after antibiotic disruption of normal microbiota cause growth impairment, watery diarrhea, heavy stool shedding and mild to moderate intestinal inflammation, the latter worse with zinc deficiency...
April 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29627419/health-risk-assessment-of-heavy-metals-in-freshwater-fish-in-the-central-and-eastern-north-china
#15
Wenjue Zhong, Yanfeng Zhang, Zihao Wu, Rongyan Yang, Xinyue Chen, Jing Yang, Lingyan Zhu
The distribution and potential health risks of eight heavy metals (Copper (Cu), Chromium (Cr), Zinc (Zn), Lead (Pb), Arsenic (As), Cadmium (Cd), Manganese (Mn), Nickel (Ni)) in 16 freshwater systems from central and eastern North China, were investigated. The fish were divided as wild fish, which grew naturally without artificially feeding, and farmed fish. The total concentrations of the eight heavy metals ranged from 82.9 to 226 μg/L in the surface water samples and 3.32-27.6 mg/kg dw in the fish samples...
April 5, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29622578/relationship-between-islet-autoantibody-status-and-the-clinical-characteristics-of-children-and-adults-with-incident-type-1-diabetes-in-a-uk-cohort
#16
Vassiliki Bravis, Akaal Kaur, Helen C Walkey, Ian F Godsland, Shivani Misra, Polly J Bingley, Alistair J K Williams, David B Dunger, Colin M Dayan, Mark Peakman, Nick S Oliver, Desmond G Johnston
OBJECTIVES: To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. DESIGN: Observational cohort study. SETTING: 146 mainly secondary care centres across England and Wales. PARTICIPANTS: 3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network...
April 4, 2018: BMJ Open
https://www.readbyqxmd.com/read/29620600/environmental-enteropathy-micronutrient-adequacy-and-length-velocity-in-nepalese-children-the-mal-ed-birth-cohort-study
#17
Marianne S Morseth, Sigrun Henjum, Catherine Schwinger, Tor A Strand, Sanjaya K Shrestha, Binob Shrestha, Ram K Chandyo, Manjeswori Ulak, Liv Elin Torheim
OBJECTIVES: Environmental enteropathy (EE) is likely associated with growth retardation in children, but the association between EE and length velocity z-score (LVZ) has not been investigated. The objective of the study was to assess associations between fecal markers for intestinal inflammation and LVZ and whether these associations were influenced by micronutrient adequacy among 9-24 months old children in Bhaktapur, Nepal. METHODS: Data was divided into 5 time slots (9-12, 12-15, 15-18, 18-21 and 21-24 months)...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29618936/trace-elements-and-oxidative-stress-in-children-with-type-1-diabetes-mellitus
#18
Ashgan Abdalla Alghobashy, Usama M Alkholy, Mohamed A Talat, Nermin Abdalmonem, Ahmed Zaki, Ihab A Ahmed, Randa H Mohamed
Background: The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D. Methods: A case-control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29607430/immunomodulator-effect-of-topical-zinc-oxide-application-in-tuberculin-skin-test
#19
Cagatay Nuhoglu, Evrim Hepkaya, Zehra Esra Onal, Narin Akici, Tamay Gurbuz, Vildan Atasayan, Omer Ceran
OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29603391/cut-off-serum-zinc-concentration-affecting-the-appetite-growth-and-nutrition-status-of-undernourished-children-supplemented-with-zinc
#20
Hsun-Chin Chao, Yi-Jung Chang, Wan-Ling Huang
BACKGROUND: Zinc supplementation has varied effects on the linear growth of children who exhibited stunted growth. MATERIALS AND METHODS: This observational study involved 761 undernourished children, aged 2-10 years, who received a 24-week course of 10-mg elemental zinc per day. The clinical parameters for evaluation included appetite, height, weight, and body mass index (BMI). Evaluation of the effect of zinc supplementation was stratified by the initial serum zinc concentration...
March 30, 2018: Nutrition in Clinical Practice
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