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differentiated thyroid carcinoma

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https://www.readbyqxmd.com/read/28434042/erratum-to-curcumin-induces-g2-m-arrest-apoptosis-nf-%C3%AE%C2%BAb-inhibition-and-expression-of-differentiation-genes-in-thyroid-carcinoma-cells
#1
Suzan Schwertheim, Frederik Wein, Klaus Lennartz, Karl Worm, Kurt Werner Schmid, Sien-Yi Sheu-Grabellus
No abstract text is available yet for this article.
April 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28428828/bioinformatics-analysis-of-key-genes-and-latent-pathway-interactions-based-on-the-anaplastic-thyroid-carcinoma-gene-expression-profile
#2
Yun Huang, Yiming Tao, Xinying Li, Shi Chang, Bo Jiang, Feng Li, Zhi-Ming Wang
Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated with ATC. The GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, which included 11 ATC and 45 normal thyroid samples. The differentially expressed genes (DEGs) in ATC were identified using the Limma package in R. The Gene Ontology functions and Kyoto Encyclopedia of Genes and Genomes pathways of the selected DEGs were enriched using the Database for Annotation, Visualization and Integrated Discovery...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28425432/angiogenic-and-lymphangiogenic-profiles-in-histological-variants-of-papillary-thyroid-carcinoma
#3
Vesna Skuletic, Gordana D Radosavljevic, Jelena Pantic, Bojana Simovic Markovic, Ivan Jovanovic, Nikola Jankovic, Dusica Petrovic, Andra Jevtovic, Radan Dzodic, Nebojsa Arsenijevic
INTRODUCTION    Papillary thyroid carcinoma (PTC) is a well-differentiated tumor that occurs in several histological variants whose biological behaviors remain unclear. Angiogenesis and lymphangiogenesis are critical processes that enable tumor progression.  OBJECTIVES    The purpose of this study was to evaluate the angiogenic and lymphangiogenic phenotypes of PTC considering the differences between histological variants. PATIENTS AND METHODS    Angiogenic and lymphangiogenic profiles were analyzed by microvascular density (MVD) and lymphovascular density (LVD) determination in 73 cases of PTC using immunohistochemistry...
April 20, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28423638/her-inhibitor-promotes-braf-mek-inhibitor-induced-redifferentiation-in-papillary-thyroid-cancer-harboring-brafv600e
#4
Lingxiao Cheng, Yuchen Jin, Min Liu, Maomei Ruan, Libo Chen
Redifferentiation therapy with BRAF/MEK inhibitors to facilitate treatment with radioiodine represents a good choice for radioiodine-refractory differentiated thyroid carcinoma, but recent initial clinical outcomes were modest. MAPK rebound caused by BRAF/MEK inhibitors-induced activation of HER2/HER3 is a resistance mechanism, and combination with HER inhibitor to prevent MAPK rebound may sensitize BRAFV600E-mutant thyroid cancer cells to redifferentiation therapy. To evaluate if inhibiting both BRAF/MEK and HER can produce stronger redifferetiation effect, we tested the effects of BRAF/MEK inhibitor dabrafenib/selumetinib alone or in combination with HER inhibitor lapatinib on the expression and function of iodine- and glucose-handling genes in BRAFV600E-positive BCPAP and K1 cells, using BHP 2-7 cells harboring RET/PTC1 rearrangement as control...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423545/hobnail-variant-of-papillary-thyroid-carcinoma-molecular-profiling-and-comparison-to-classical-papillary-thyroid-carcinoma-poorly-differentiated-thyroid-carcinoma-and-anaplastic-thyroid-carcinoma
#5
Lianghong Teng, Wanglong Deng, Junliang Lu, Jing Zhang, Xinyu Ren, Huanli Duan, Shannon Chuai, Feidie Duan, Wei Gao, Tao Lu, Huanwen Wu, Zhiyong Liang
BACKGROUND: As a rare but aggressive papillary thyroid carcinoma (PTC) variant, the genetic changes of hobnail variant of PTC (HVPTC) are still unclear. RESULTS: The prevalence of HVPTC was 1.69% (18/1062) of all PTC diagnosed in our cohort. 73 samples from 55 patients (17 HVPTC, 26 CPTC, 7 PDTC and 5 ATC) were successfully analyzed using targeted NGS with an 18-gene panel. Thirty-seven mutation variant types were identified among 11 genes. BRAF V600E mutation was the most common mutation, which is present in almost all HVPTC samples (16/17, 94%), most CPTC samples (20/26, 77%), and none of the ATC and PDTC samples...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420659/very-low-expression-of-pd-l1-in-medullary-thyroid-carcinoma
#6
Massimo Bongiovanni, Caterina Rebecchini, Chiara Saglietti, Jean-Luc Bulliard, Laura Marino, Laurence De Leval, Gerasimos P Sykiotis
Monoclonal antibodies that inhibit the interaction between PD1 and PD-L1 are approved for clinical use in several cancer types, and they are also in clinical trials for additional indications, including thyroid carcinomas. A few papers have reported on PD-L1 expression in thyroid carcinomas, including a recent large study by Ahn et al. in Endocrine-Related Cancer using tissue microarrays on differentiated and anaplastic thyroid carcinoma. However, the expression of PD-L1 in medullary thyroid carcinoma (MTC) has not been reported so far, even though ongoing clinical studies aim to test the effectiveness of checkpoint inhibitors in this rare histotype as well...
April 18, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28419762/hobnail-variant-of-papillary-thyroid-carcinoma-a-case-with-an-unusual-presentation
#7
Mohammed T Lilo, Justin A Bishop, Syed Z Ali
Variants of papillary thyroid carcinoma (PTC) account for up to 25% of the cases, some of which are proven to be associated with aggressive clinical behavior such as tall cell and columnar cell variants. Hobnail variant of PTC (HVPTC) is recently described as a rare and aggressive variant of PTC. Herein, we are reporting a case of HVPTC in a patient who presented with hemoptysis and an intratracheal blood clot that was aspirated and submitted for cytopathological examination. Cytomorphology displayed neoplastic cells with profound micropapillary architecture, elongated nuclei, and prominent hobnail configuration...
April 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28417929/histogram-analysis-of-diffusion-weighted-imaging-at-3t-is-useful-for-prediction-of-lymphatic-metastatic-spread-proliferative-activity-and-cellularity-in-thyroid-cancer
#8
Stefan Schob, Hans Jonas Meyer, Julia Dieckow, Bhogal Pervinder, Nikolaos Pazaitis, Anne Kathrin Höhn, Nikita Garnov, Diana Horvath-Rizea, Karl-Titus Hoffmann, Alexey Surov
Pre-surgical diffusion weighted imaging (DWI) is increasingly important in the context of thyroid cancer for identification of the optimal treatment strategy. It has exemplarily been shown that DWI at 3T can distinguish undifferentiated from well-differentiated thyroid carcinoma, which has decisive implications for the magnitude of surgery. This study used DWI histogram analysis of whole tumor apparent diffusion coefficient (ADC) maps. The primary aim was to discriminate thyroid carcinomas which had already gained the capacity to metastasize lymphatically from those not yet being able to spread via the lymphatic system...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28414279/short-term-effects-of-radioiodine-therapy-on-auditory-function
#9
Deniz Tuna Edizer, Suat Bilici, Muhammet Yıldız, Özgür Yiğit, Tevfik Fikret Çermik
OBJECTIVE: Radioiodine therapy (RIT) is frequently utilized as an adjunctive treatment option for differentiated thyroid carcinoma following surgical intervention. The side effects of RIT are considered to emerge as a result of radioiodine accumulation in non-thyroidal tissues capable of iodine uptake. We aimed to evaluate the effects of RIT on auditory function. MATERIALS AND METHODS: Patients who had undergone total thyroidectomy and diagnosed to have differentiated thyroid carcinoma were analyzed...
April 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28413206/differential-diagnostic-significance-of-hbme-1-ck19-and-s100-in-various-thyroid-lesions
#10
S Palo, D S Biligi
OBJECTIVE: Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions. MATERIALS AND METHODS: Immunohistochemical analysis of 60 thyroidectomy specimens (10 hyperplastic nodules, 14 follicular adenomas and 36 malignant thyroid neoplasms) was carried out...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28411177/expression-of-mrp1-and-abcg2-is-associated-with-adverse-clinical-outcomes-of-the-papillary-thyroid-carcinoma-with-a-solid-component
#11
Ryuji Ohashi, Kiyoko Kawahara, Shigeki Namimatsu, Ritsuko Okamura, Takehito Igarashi, Iwao Sugitani, Zenya Naito
Solid variant of papillary thyroid carcinoma is characterized by a solid component (SC) retaining classical cytological features of papillary thyroid carcinoma (PTC). Despite some controversies, PTC cases with SC (PTCSC) have poor prognosis compared to well-differentiated PTC. We investigated if cancer stem cells (CSC) may have a role in pathogenesis of PTCSC. PTCSC tumors (n=27) was histologically represented by mixture of papillary component (PC) and varying degree of SC involving 10-85% of the tumor. Immunohistochemical expression of CSC markers ABCG2 and MRP1, and HBME1 and CK19 was compared between SC and PC within each tumor in association with clinicopathological parameters...
April 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/28409442/surgical-management-of-medullary-thyroid-carcinoma
#12
REVIEW
Agathoklis Konstantinidis, Michael Stang, Sanziana A Roman, Julie Ann Sosa
Medullary thyroid cancer (MTC) is a malignant tumor of the parafollicular C cells of the thyroid and comprises only 1-2% of all thyroid cancer cases. Unlike most differentiated thyroid cancer, MTC is associated with a mean survival of 8.6 years and accounts for a disproportionate 8.6% of thyroid cancer deaths. Surgery is the mainstay of treatment for loco-regional disease and the only current means of cure for MTC. The relatively low incidence of MTC has made the comprehensive study of this disease difficult and most research to date has been based largely on single institution, retrospective, and/or non-randomized studies...
April 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28408701/low-grade-mucoepidermoid-tumor-of-parotid-gland-presenting-as-focal-asymmetry-in-the-follow-up-radioiodine-scan-in-a-patient-of-differentiated-papillary-carcinoma-of-thyroid
#13
Chinna Naik, Sandip Basu
Low grade mucoepidermoid tumor of the right parotid gland presenting as focal uptake in the follow-up whole body iodine scan in a patient of differentiated papillary carcinoma of thyroid 1 year after successful ablation is presented in this report. Following surgical excision, the histopathology was proven. The illustrated case represents false positive focal accumulation of (131)I in low grade mucoepidermoid carcinoma of the salivary gland that arose early in the follow-up course in differentiated thyroid carcinoma post-radioiodine (RAI)...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28404918/human-a-l-fucosidase-1-attenuates-the-invasive-properties-of-thyroid-cancer
#14
Giancarlo Vecchio, Alessia Parascandolo, Chiara Allocca, Clara Ugolini, Fulvio Basolo, Marco Moracci, Andrea Strazzulli, Beatrice Cobucci-Ponzano, Mikko O Laukkanen, Maria Domenica Castellone, Nobuo Tsuchida
Glycans containing α-L-fucose participate in diverse interactions between cells and extracellular matrix. High glycan expression on cell surface is often associated with neoplastic progression. The lysosomal exoenzyme, α-L-fucosidase-1 (FUCA-1) removes fucose residues from glycans. The FUCA-1 gene is down-regulated in highly aggressive and metastatic human tumors. However, the role of FUCA-1 in tumor progression remains unclear. It is speculated that its inactivation perturbs glycosylation of proteins involved in cell adhesion and promotes cancer...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401794/chinese-data-of-efficacy-of-low-and-high-dose-of-iodine-131-for-the-ablation-of-thyroid-remnant
#15
Chao Ma, Fang Feng, Shaoyan Wang, Hongliang Fu, Shuqi Wu, Zhiyi Ye, Suyun Chen, Hui Wang
BACKGROUND: Chinese data of efficacy of low- and high-dose of radioiodine for thyroid remnant is still absent. The aim of the study is to investigate whether the low-dose of radioiodine is as effective as high-dose for remnant ablation in Chinese patients. METHODS: Patients presenting for radioiodine ablation in our department were included. Inclusion criteria were an age of 16 years or older; total or near total thyroidectomy; tumor-node-metastasis (TNM) stage of pT1-3, any N stage and M0...
April 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28396808/usefulness-of-stereotactic-radiotherapy-using-cyberknife-for-recurrent-lymph-node-metastasis-of-differentiated-thyroid-cancer
#16
Joji Kawabe, Shigeaki Higashiyama, Mitsuharu Sougawa, Atsushi Yoshida, Kohei Kotani, Susumu Shiomi
A woman in her 60s presented with a recurrent lymph node metastasis from a papillary thyroid carcinoma in the right parapharyngeal space. She had already undergone total thyroidectomy, five resections for cervical lymph node metastases, and right carotid rebuilding. Surgical resection of the current metastasis was impossible. (131)I-radioiodine therapy (RIT) with 3.7 GBq (131)I was not effective; therefore, stereotactic radiation therapy (SRT) using a CyberKnife radiotherapy system was scheduled. The prescription dose was 21 Gy, and a dose covering 95% of the planning target volume (PTV) in three fractions was administered...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28393379/surveillance-neck-sonography-after-thyroidectomy-for-papillary-thyroid-carcinoma-pitfalls-in-the-diagnosis-of-locally-recurrent-and-metastatic-disease
#17
Wynne Yuru Chua, Jill E Langer, Lisa P Jones
A sonographic examination of the neck performed 6 to 12 months after thyroid surgery in patients with differentiated thyroid cancer is strongly recommended by the American Thyroid Association and considered mandatory by the European Thyroid Association for locoregional surveillance. The aim of this article is to review the normal anatomic changes expected after thyroid surgery and the pathologic mimics of thyroid carcinoma recurrence in post-thyroidectomy patients as they appear on neck sonography. We hope to offer some pearls to increase diagnostic confidence in this setting...
April 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28390289/lenvatinib-an-oral-multi-kinases-inhibitor-associated-hypertension-potential-role-of-vascular-endothelial-dysfunction
#18
Daisuke Sueta, Koichi Suyama, Aiko Sueta, Noriaki Tabata, Takayoshi Yamashita, Mai Tomiguchi, Takashi Takeshita, Mutsuko Yamamoto-Ibusuki, Eiichiro Yamamoto, Yasuhiro Izumiya, Koichi Kaikita, Yutaka Yamamoto, Seiji Hokimoto, Hirotaka Iwase, Kenichi Tsujita
BACKGROUND AND AIMS: Lenvatinib (Lenvima(®)), an oral multi-kinase inhibitor, is effective in the treatment of differentiated thyroid carcinomas (DTCs). A severe adverse effect of lenvatinib is hypertension, thus limiting its use as an anti-cancer treatment. Although the pathogenesis of hypertension is generally assumed to involve microvascular bed reduction and an increase in peripheral vascular resistance due to a decrease in nitrogen oxide (NOx) production after vascular endothelial growth factor (VEGF) inhibition, the effects of hypertension on vascular endothelial function in actual patients remain unclear...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28385370/thyroid-cancer-surgery-guidelines-in-an-era-of-de-escalation
#19
REVIEW
K J Kovatch, C W Hoban, A G Shuman
Well-differentiated thyroid carcinoma has seen a tremendous rise in global incidence over the past three decades, largely owing to widespread screening and identification of small, incidentally detected tumors. With this increased incidence has emerged a movement questioning whether all cases of thyroid cancer merit a treatment approach focused on oncologic completeness. Such trends towards thoughtful, evidence-based treatment de-escalation paradigms reflect better risk stratification of thyroid cancers, and recognition that not all detected disease poses a threat to health or survival...
March 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28384879/primary-sarcomas-of-thyroid-gland-series-of-three-cases-with-brief-review-of-spindle-cell-lesions-of-thyroid
#20
Amita Jain Gupta, Meeta Singh, Poonam Rani, Nita Khurana, Anurag Mishra
Primary Malignant Fibrous Histiocytoma (MFH-T) and Leiomyosarcoma (LMS-T) of the thyroid gland are extremely rare tumors. Very few cases have been reported in the literature. Both entities occur more commonly in women than men. The closest clinical and histological differential diagnosis is anaplastic carcinoma of thyroid. We present three cases of rare primary sarcomas of thyroid gland. Case-1 was a 63-year-old woman and Case-2 was a 52-year-old woman. Both of them presented with a rapidly increasing thyroid mass clinically mimicking anaplastic carcinoma (AC-T)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
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