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differentiated thyroid carcinoma

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https://www.readbyqxmd.com/read/28088877/the-concerted-action-of-type-2-and-type-3-deiodinases-regulates-the-cell-cycle-and-survival-of-basal-cell-carcinoma-cells
#1
Caterina Miro, Raffaele Ambrosio, Maria Angela De Stefano, Daniela Di Girolamo, Emery Di Cicco, Annunziata Gaetana Cicatiello, Giuseppina Mancino, Tommaso Porcelli, Maddalena Raia, Luigi Del Vecchio, Domenico Salvatore, Monica Dentice
BACKGROUND: Thyroid hormones (THs) mediate pleiotropic cellular processes involved in metabolism, cellular proliferation and differentiation. The intracellular hormonal environment can be tailored by the deiodinase enzymes, D2 and D3, which catalyze TH activation and inactivation, respectively. In many cellular systems, THs exert well documented stimulatory or inhibitory effects on cell proliferation, however, the molecular mechanisms by which they control rates of cell cycle progression have not yet been entirely clarified...
January 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28088233/successful-recovery-from-a-subclavicular-ulcer-caused-by-lenvatinib-for-thyroid-cancer-a-case-report
#2
Morimasa Kitamura, Tomomasa Hayashi, Chiaki Suzuki, Shigeru Hirano, Ichiro Tateya, Yo Kishimoto, Koichi Omori
BACKGROUND: There are currently no effective therapeutic methods for locally recurrent, metastatic, or progressive radioactive iodine (RAI)-refractory differentiated thyroid cancer. However, multitargeted tyrosine kinase inhibitors (TKIs) such as lenvatinib or sorafenib have been approved for patients with RAI-refractory differentiated thyroid cancer as a second targeted therapy, and these agents can prolong patient survival. However, several cases have been reported that TKIs have caused fatal complications such as fistula formation or bleeding...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28088216/immunohistochemical-features-of-giant-cell-ependymoma-of-the-filum-terminale-with-unusual-clinical-and-radiological-presentation
#3
Fernando Candanedo-Gonzalez, Cindy Sharon Ortiz-Arce, Samuel Rosales-Perez, Ana Lilia Remirez-Castellanos, Candelaria Cordova-Uscanga, Armando Gamboa-Dominguez
BACKGROUND: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior. CASE PRESENTATION: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion...
January 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28072974/-clinicopathologic-features-of-mammary-analogue-secretory-carcinoma-of-salivary-glands
#4
X P Zhang, H Ni, X Wang, H Chen, S S Shi, B Yu, X J Zhou, Q Rao
Objective: To investigate the clinicopathological features of mammary analogue secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential diagnosis, immunohistochemistry and molecular pathology. Methods: Seventeen cases of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital from 1997 to 2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28054519/radioiodine-as-an-adjuvant-therapy-and-its-role-in-follow-up-of-differentiated-thyroid-cancer
#5
REVIEW
S Padma, P Shanmuga Sundaram
Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. It has the same physical properties as stable iodine, thus both normal and malignant thyrocytes cannot differentiate radioactive from stable iodine...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28050206/thyroid-carcinoma-pattern-presentation-according-to-age
#6
Fábio Muradás Girardi
Introduction Patients with thyroid cancer in different age groups present with different prognosis. Objective The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups. Methods This is a retrospective study. From 2000 to 2010, 623 patients underwent thyroidectomy for cancer in our institution, with 596 enrolled. Patients were divided into groups of 10 years and then in four age subgroups (≤ 24, 25-44, 45-64, and ≥65 years) for statistical analysis...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28049373/long-term-follow-up-for-differentiated-thyroid-carcinoma-patients-a-reconsideration
#7
Robin A L van der Wardt, Adrienne C M Persoon, Esther N Klein Hesselink, Thera P Links
N/A.
January 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28049366/primary-thyroid-carcinoma-with-low-risk-histology-and-distant-metastases-clinico-pathologic-and-molecular-characteristics
#8
Bin Xu, R Michael Tuttle, Mona Sabra, Ian Ganly, Ronald Ghossein
BACKGROUND: Distant metastases (DM) are a rare occurrence in well differentiatedwell-differentiated thyroid carcinoma. The aim of our study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low risk histology that develop DM. METHODS: Detailed clinico-pathologic review and targeted next generation sequencing were performed on a cohort of well-differentiatedwell-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion or significant lymph node metastases but exhibiting distant metastases...
January 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28048806/su-g-iep4-05-experience-with-a-practical-approach-to-the-release-of-radioactive-patients-from-radiation-safety-isolation
#9
R Wendt, W Erwin, A Fisher, S Jones, S Jimenez, F Wong, A Jessop
PURPOSE: The radioactive patient releases of the nuclear medicine department in a large cancer center were analyzed to compare the estimated doses to others to the regulatory limit and institutional targets and to gauge how onerous the patients' instructions were. METHODS: In-house software that implements the NUREG 1556 approach and further considers fellow travelers, children and pregnant women and members of the public following Siegel, et al., is used to calculate release timing and to provide patients with individualized instructions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039715/identification-of-differential-pathways-in-papillary-thyroid-carcinoma-utilizing-pathway-co-expression-analysis
#10
Wei-Hai Qiu, Gui-Yan Chen, Lu Cui, Ting-Ming Zhang, Feng Wei, Yong Yang
PURPOSE: To identify differential pathways between papillary thyroid carcinoma (PTC) patients and normal controls utilizing a novel method which combined pathway with co-expression network. METHODS: The proposed method included three steps. In the first step, we conducted pretreatments for background pathways and gained representative pathways in PTC. Subsequently, a co-expression network for representative pathways was constructed using empirical Bayes (EB) approach to assign a weight value for each pathway...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28038793/histologic-characteristics-of-thymic-adenocarcinomas-clinicopathologic-study-of-a-nine-case-series-and-a-review-of-the-literature
#11
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Primary thymic adenocarcinoma is an extraordinarily rare malignancy; only 49 cases have been reported in the medical literature to date. Because of its rarity, clinical and pathologic characteristics of thymic adenocarcinoma are unclear. We present nine cases of primary thymic adenocarcinoma and discuss clinicopathologic findings in the context of the existing literature. Two-hundred twenty-six thymic carcinoma cases were diagnosed at Samsung Medical Center in Korea, from January, 2001 to July, 2016. Nine of these 226 cases were primary thymic adenocarcinomas...
November 15, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28030816/down-regulation-of-14q32-encoded-mirnas-and-tumor-suppressor-role-for-mir-654-3p-in-papillary-thyroid-cancer
#12
Murilo Vieira Geraldo, Helder Imoto Nakaya, Edna Teruko Kimura
Papillary thyroid carcinoma (PTC) is the most prevalent malignant neoplasia of the thyroid gland. A fraction of PTC cases show loss of differentiation and aggressive behavior, with radioiodine therapy resistance and metastasis. Although microRNAs (miRNAs) emerged as promising molecular markers for PTC, their role in the loss of differentiation observed during PTC progression remains to be fully understood. We performed the large-scale analysis of miRNA expression during PTC progression in BRAFT1799A-transgenic animals (Tg-Braf) and thyroid cancer cell lines and identified the marked downregulation of several miRNAs from the region 14q32...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028343/cribriform-morular-variant-of-papillary-thyroid-carcinoma-cytomorphology-differential-diagnosis-and-diagnostic-implications-in-patients-with-adenomatous-polyposis-coli
#13
Amarathunga Ah Priyani, Shamika T Opatha, Nisayuri W Gunathilake, Menaka Ds Lokuhetty
Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC), which has a better prognosis, is seen mostly in the setting of familial adenomatous polyposis (FAP). The cytomorphology of CMV-PTC is diverse; hence, it could be mistaken for other thyroid neoplasms with bad prognostic outcome. This case is of a 24-year-old female diagnosed with polyposis coli found to have thyroid nodules at screening ultrasonography. Aspirated thyroid smears were hypercellular with epithelial cells arranged in monolayer sheets, papillae with discohesion, and spindling of cells at the edges, cribriform clusters, and cell morules...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28028337/thyroid-fnac-containing-h%C3%A3-rthle-cells-and-h%C3%A3-rthle-like-cells-a-study-of-128-cases
#14
Aylin Yazgan, Serdar Balci, Nazmiye Dincer, Pamir Eren Ersoy, Dilek Tuzun, Reyhan Ersoy, Cigdem Irkkan, Bekir Cakir, Gulnur Guler
AIM: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterpretation is caused by PTC cells with large cytoplasm-like Hürthle cells. The aim of this study is to predict histologic outcome of the nodules, which have Hürthle cells in FNA according to cytological, clinical features, and BRAF(V600E) mutation status...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28024929/kidney-involvement-in-systemic-calcitonin-amyloidosis-associated-with-medullary-thyroid-carcinoma
#15
Timco Koopman, Cindy Niedlich-den Herder, Coen A Stegeman, Thera P Links, Johan Bijzet, Bouke P C Hazenberg, Arjan Diepstra
A 52-year-old woman with widely disseminated medullary thyroid carcinoma developed nephrotic syndrome and slowly decreasing kidney function. A kidney biopsy was performed to differentiate between malignancy-associated membranous glomerulopathy and tyrosine kinase inhibitor-induced focal segmental glomerulosclerosis. Surprisingly, the biopsy specimen revealed diffuse glomerular deposition of amyloid that was proved to be derived from the calcitonin hormone (Acal), produced by the medullary thyroid carcinoma...
December 23, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28011713/germline-compound-heterozygous-poly-glutamine-deletion-in-usf3-may-be-involved-in-predisposition-to-heritable-and-sporadic-epithelial-thyroid-carcinoma
#16
Ying Ni, Spencer Seballos, Benjamin Fletcher, Todd Romigh, Lamis Yehia, Jessica Mester, Leigha Senter, Farshad Niazi, Motoyasu Saji, Matthew D Ringel, Thomas LaFramboise, Charis Eng
Cowden syndrome (CS) is an autosomal dominant disorder that predisposes to breast, thyroid, and other epithelial cancers. Differentiated thyroid carcinoma (DTC), as one of the major component cancers of CS, is the fastest rising incident cancer in the USA, and the most familial of all solid tumors. To identify additional candidate genes of CS and potentially DTC, we analyzed a multi-generation CS-like family with papillary thyroid cancer (PTC), applying a combined linkage-based and whole-genome sequencing strategy and identified an in-frame germline compound heterozygous deletion, p...
December 22, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28007013/dynamic-risk-estimates-of-outcome-in-chinese-patients-with-well-differentiated-thyroid-cancer-after-total-thyroidectomy-and-radioactive-iodine-remnant-ablation
#17
Feng Chih Shen, Ching-Jung Hsieh, I Chin Huang, Yen Hsiang Chang, Pei Wen Wang
Background This study was conducted to compare the staging systems for the prediction of long-term disease status in patients with well-differentiated thyroid carcinoma (WDTC), and find out the earliest postoperative period predictor of long-term persistence/recurrence of disease. Methods Patients with WDTC (n=356, age 41.5 ± 12.7 years) followed for at least 5 years (12.3 ± 5.0 years) after thyroidectomy and 131I remnant ablation at a tertiary regional hospital in Taiwan were retrospectively studied. Each patient was risk-stratified using the American Joint Cancer Committee (AJCC) (stage I-IV), American Thyroid Association (ATA) (low, intermediate, high risk) staging systems after operation and first 131I remnant ablation and using response to initial therapy reclassification (RTR) (excellent, indeterminate, biochemical incomplete, structural incomplete response) system, which is determined 6-24 months after the first 131I ablation...
December 22, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28004221/overexpression-of-teneurin-transmembrane-protein-1-is-a-potential-marker-of-disease-progression-in-papillary-thyroid-carcinoma
#18
Shih-Ping Cheng, Ming-Jen Chen, Ming-Nan Chien, Chi-Hsin Lin, Jie-Jen Lee, Chien-Liang Liu
Although papillary thyroid cancer is a relatively indolent malignancy, its progression may be associated with dedifferentiation and resistance to radioactive iodine treatment. In this study, patterns of differentially expressed genes in association with disease progression were systemically evaluated. We firstly performed transcriptome analyses for four matched cancerous and noncancerous tissue pairs of the classical subtype of papillary thyroid cancer. Among the upregulated and downregulated genes, the expression of 164 and 183 genes increased and decreased, respectively, from stage I to stage IV...
December 21, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28004113/suberoyl-bis-hydroxamic-acid-activates-notch1-signaling-and-induces-apoptosis-in-anaplastic-thyroid-carcinoma-through-p53
#19
Jiansen Li, Xiangqian Zheng, Ming Gao, Jingzhu Zhao, Yigong Li, Xiangrui Meng, Biyun Qian, Jiafeng Li
Anaplastic thyroid cancer (ATC), usually derived from well-differentiated thyroid cancers is one of the most lethal human endocrine malignancies. In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular domain could not be detected in ATC-CAL-62 cells. Interesting, suberoyl bis-hydroxamic acid (SBHA) administration could induce Notch1 intracellular domain levels in a dose-dependent manner, coupled with the increase of p53 and p21. Furthermore, ectopic expression of Notch1 or deletion of p53 with small-interfering RNA was able to abolish the effects of SBHA to elevation of Notch1 and p53 in ATC cells...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/28002173/higher-preablative-serum-thyroid-stimulating-hormone-level-predicts-radioiodine-ablation-effectiveness-in-patients-with-differentiated-thyroid-carcinoma
#20
Ismaheel O Lawal, Nozipho E Nyakale, Lerwine M Harry, Thabo Lengana, Neo P Mokgoro, Mariza Vorster, Mike M Sathekge
INTRODUCTION: Radioiodine ablation of remnant thyroid tissue is an important adjuvant therapy of differentiated thyroid carcinoma (DTC) after thyroidectomy. Elevated serum thyroid-stimulating hormone (TSH) level is necessary for successful ablation. The optimum level of serum TSH level necessary for successful radioiodine ablation of well-DTC is, however, yet to be defined. We aimed to determine whether higher serum TSH level will result in a better rate of complete ablation of well-DTC using iodine-131 (I) following initial thyroidectomy...
December 20, 2016: Nuclear Medicine Communications
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