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differentiated thyroid carcinoma

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https://www.readbyqxmd.com/read/29453554/in-vitro-studies-of-dna-damage-and-repair-mechanisms-induced-by-bnct-in-a-poorly-differentiated-thyroid-carcinoma-cell-line
#1
C Rodriguez, M Carpano, P Curotto, S Thorp, M Casal, G Juvenal, M Pisarev, M A Dagrosa
Boron neutron capture therapy (BNCT) for aggressive tumors is based on nuclear reaction [ 10 B (n, α) 7 Li]. Previously, we demonstrated that BNCT could be applied for the treatment of undifferentiated thyroid carcinoma. The aim of the present study was to describe the DNA damage pattern and the repair pathways that are activated by BNCT in thyroid cells. We analyzed γH2AX foci and the expression of Ku70, Rad51 and Rad54, main effector enzymes of non-homologous end joining (NHEJ) and homologous recombination repair (HRR) pathways, respectively, in thyroid follicular carcinoma cells...
February 16, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29451347/a-rare-case-of-ectopic-papillary-thyroid-carcinoma-transformed-into-squamous-cell-carcinoma
#2
Hironao Yasuoka, Yasushi Nakamura, Ken-Ichi Yoshida, Toshiro Shimo, Masayuki Tori, Yuuki Matsui, Yasushi Sakamaki, Masahiko Tsujimoto
A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. During the post-operative follow-up period, a rapidly growing 2 cm nodular lesion in the lower left lobe of the lung was detected...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29449729/parotid-metastasis-of-renal-cell-carcinoma-mimicking-primary-clear-cell-oncocytoma-report-of-a-case-and-brief-review-of-the-literature
#3
B J Rocca, A Gini, C Calandra, A Ginori, F Crivelli
Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. RCC has an unpredictable behavior and the unique potential to metastasize to nearly every organ in the body. Though not as frequent, metastatic RCC to the head and neck has been identified in the thyroid, salivary glands, skull base, sinuses, pharynx, tonsils, tongue, lip and skin...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29446856/thyroid-carcinoma-producing-%C3%AE-human-chorionic-gonadotropin-shows-different-clinical-behavior
#4
Haiyan Gu, Shaofeng Sui, Xiujie Cui, Bo Han, Chunyan Zhang, Mei Qi, Congcong Li, Zhiyan Liu
Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β-hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses...
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29446670/diagnostic-performance-of-margin-features-in-thyroid-nodules-in-prediction-of-malignancy
#5
Sean M Siebert, Adam J Gomez, Tie Liang, Ali M Tahvildari, Terry S Desser, R Brooke Jeffrey, Aya Kamaya
OBJECTIVE: The purpose of this study was to evaluate thyroid nodule margins for specific morphologic features and determine the diagnostic performance of these features in differentiating papillary carcinoma from benign thyroid nodules. MATERIALS AND METHODS: Nodules measuring 1-3 cm in largest diameter that had been evaluated with high-resolution ultrasound (12-18 MHz) and ultrasound-guided biopsy with definitive pathologic diagnosis were analyzed. Three blinded board-certified readers evaluated high-resolution images of each nodule for jagged edges, lobulated borders, and curved borders along their margins...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29445865/risk-of-recurrence-in-a-homogeneously-managed-pt3-differentiated-thyroid-carcinoma-population
#6
Nathalie Chereau, Etienne Dauzier, Gaëlle Godiris-Petit, Séverine Noullet, Isabelle Brocheriou, Laurence Leenhardt, Camille Buffet, Fabrice Menegaux
BACKGROUND: International guidelines for the management of differentiated thyroid cancers are based on the 7th TNM classification: pT3 tumors are defined as differentiated thyroid cancers (DTCs) measuring more than 4 cm in their greatest dimension that are limited to the thyroid or any tumor with minimal extrathyroidal extension (ETE; sternothyroid muscle or perithyroid soft tissues). Differences in clinicohistological features and prognosis among patients with pT3 tumors remain controversial, and studies regarding pT3 subgroups are lacking...
February 14, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29442477/role-of-thyroid-ultrasound-combined-with-thyroglobulin-in-the-diagnosis-of-postoperative-recurrence-of-thyroid-cancer
#7
Li Zhang, Guilan Zou
BACKGROUND: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice. METHODS: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29439609/-i-braf-i-and-i-ras-i-mutational-status-in-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-invasive-subtype-of-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-in-korea
#8
Mijin Kim, MinJi Jeon, Hye-Seon Oh, Suyeon Park, Tae Yong Kim, YoungKee Shong, Won Bae Kim, Kyunggon Kim, Won Gu Kim, Dong Eun Song
BACKGROUND: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor previously known as non-invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). The absence of <i>BRAF<sup>V600E</sup></i> mutations has been considered characteristic of NIFTPs. However, a recent study from Korea found that 28.6% of NIFTPs harbored a <i>BRAF</i> mutation. In this study, we evaluated <i>BRAF</i> and <i>RAS</i> mutations in NIFTPs and invasive subtype of EFVPTCs...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29438167/insm1-is-a-sensitive-and-specific-marker-of-neuroendocrine-differentiation-in-head-and-neck-tumors
#9
Lisa M Rooper, Justin A Bishop, William H Westra
The head and neck is the site of a wide and sometimes bewildering array of neuroendocrine (NE) tumors. Although recognition of NE differentiation may be necessary for appropriate tumor classification and treatment, traditional NE markers such as synaptophysin, chromogranin, and CD56 are not always sufficiently sensitive or specific to make this distinction. Insulinoma-associated protein 1 (INSM1) is a novel transcription factor that has recently demonstrated excellent sensitivity and specificity for NE differentiation in various anatomic sites, but has not yet been extensively evaluated in tumors of the head and neck...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29433884/squamous-differentiation-in-papillary-thyroid-carcinoma-a-rare-feature-of-aggressive-disease
#10
Toni Beninato, Wouter P Kluijfhout, Frederick Thurston Drake, Elham Khanafshar, Jessica E Gosnell, Wen T Shen, Quan-Yang Duh, Insoo Suh
BACKGROUND: Papillary thyroid carcinoma with squamous differentiation (PTC-SD) is a poorly understood pathologic finding of unknown clinical significance. Selected case reports have suggested that PTC-SD is an aggressive tumor with a poor prognosis. Here we present the largest case series of PTC-SD reported in the United States. MATERIALS AND METHODS: The cancer registry at our tertiary care referral center was reviewed to identify all patients from 1995-2015 who had been diagnosed with PTC-SD on initial total thyroidectomy or lymph node dissection for recurrent disease...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29429327/preoperative-cytologic-diagnosis-of-warthin-like-tumor-variant-of-papillary-thyroid-carcinoma
#11
Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution...
February 12, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29427661/mir-199a-5p-inhibits-the-progression-of-papillary-thyroid-carcinoma-by-targeting-snai1
#12
Sugang Ma, Wei Jia, Shiyu Ni
BACKGROUND: Increasing evidence has emphasized the important roles of differentially expressed miRNAs in papillary thyroid cancer (PTC) development. miR-199a-5p was previously documented to be downregulated in PTCs compared with normal thyroids. However, the role of miR-199a-5p in the progression of PTC and the underlying mechanism remain to be further addressed. METHODS: miR-199a-5p and snail family zinc finger 1 (SNAI1) mRNA expressions in PTC tissues and cells were detected by qRT-PCR...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29424371/incidental-thyroid-carcinoma-in-patients-with-tir1-tir2-and-tir3-fna
#13
Angela Pezzolla, Serafina Lattarulo, Graziana Barile, Daniele Paradies, Giuseppe Pentassuglia, Francesco Prete, Rinaldo Marzaioli
AIM: The aim of our study was to evaluate the presence of incidental differentiated thyroid carcinomas, at final histological examination, in patients undergoing thyroidectomy or lobectomy for presumed benign pathology or in those with cytological diagnosis of indeterminate nodules (TIR3). MATERIAL OF STUDY: 457 patients who underwent surgery for benign disease and 179 patients with indeterminate FNA were included in our study. RESULTS: 77 out of 457 patients had the diagnosis of differentiated thyroid carcinoma...
February 9, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29423055/hyperplastic-thymus-with-increased-angiogenesis-is-correlated-with-elevated-serum-thyroglobulin-level-in-differentiated-thyroid-cancer-patients-with-tenis-syndrome
#14
Guangjian Zhang, Rui Gao, Yuanbo Wang, Yan Liu, Juan Li, Xi Jia, Yiqian Liang, Aimin Yang
Aims: To investigate the association between angiogenetic activity of hyperplastic thymus and serum thyroglobulin (Tg) level in differentiated thyroid carcinoma patients with thyroglobulin (Tg)-elevated Negative Iodine Scintigraphy (TENIS) Syndrome. Methods: A cohort of 30 consecutive patients who underwent total thyroidectomy followed by radioiodine ablation and had TENIS syndrome received integrin αvβ3 targeted imaging with 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfk)]2 (99mTc-3PRGD2)...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29417654/prevalence-of-adverse-pathological-features-in-1-to-4%C3%A2-cm-low-risk-differentiated-thyroid-carcinoma
#15
Samskruthi P Murthy, Deepak Balasubramanian, Narayana Subramaniam, Gopalakrishnan Nair, Misha J C Babu, Priyank V Rathod, Krishnakumar Thankappan, Subramania Iyer, Smitha Nalumackal Vijayan, Chaya Prasad, Vasantha Nair
BACKGROUND: The American Thyroid Association (ATA) recommends thyroid lobectomy for 1 to 4 cm tumors without adverse features. We studied the prevalence of adverse pathological features in patients eligible for unilateral lobectomy. METHODS: We conducted a retrospective study of patients who underwent total thyroidectomy. Patients with differentiated thyroid cancer (DTC) with tumors measuring 1 to 4 cm with no known preoperative adverse features were included in this study...
February 8, 2018: Head & Neck
https://www.readbyqxmd.com/read/29416784/differential-expression-profile-of-cxcr3-splicing-variants-is-associated-with-thyroid-neoplasia-potential-role-in-papillary-thyroid-carcinoma-oncogenesis
#16
Soledad Urra, Martin C Fischer, José R Martínez, Loreto Véliz, Paulina Orellana, Antonieta Solar, Karen Bohmwald, Alexis Kalergis, Claudia Riedel, Alejandro H Corvalán, Juan C Roa, Rodrigo Fuentealba, C Joaquin Cáceres, Marcelo López-Lastra, Augusto León, Nicolás Droppelmann, Hernán E González
Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for PTC development. The CXCR3-ligand system is involved in thyroid inflammation and CXCR3 has been found upregulated in many tumors, suggesting its pro-tumorigenic role under the inflammatory microenvironment. CXCR3 ligands (CXCL4, CXCL9, CXCL10 and CXCL11) trigger antagonistic responses partly due to the presence of two splice variants, CXCR3A and CXCR3B...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413688/predictive-factors-of-outcome-in-poorly-differentiated-thyroid-carcinomas
#17
Christelle de la Fouchardière, Myriam Decaussin-Petrucci, Julien Berthiller, Françoise Descotes, Jonathan Lopez, Jean-Christophe Lifante, Jean-Louis Peix, Anne-Laure Giraudet, Armelle Delahaye, Sandrine Masson, Claire Bournaud-Salinas, Françoise Borson Chazot
BACKGROUND: The prognosis of poorly differentiated thyroid carcinomas (PDTC) is heterogeneous though generally poor. The objectives of this study were to identify clinical and molecular factors of poor prognosis. METHODS: One hundred four consecutive patients treated for a PDTC between 01/01/2000 and 31/12/2010 were included in this study. A pathological review was done for all cases (blinded to clinical data and outcome). RESULTS: All patients underwent thyroidectomy...
February 2, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29412392/coexistence-of-diffuse-large-b-cell-lymphoma-and-papillary-thyroid-carcinoma-in-a-patient-affected-by-hashimoto-s-thyroiditis
#18
Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412384/thyroglobulin-levels-before-radioactive-iodine-therapy-and-dynamic-risk-stratification-after-1-year-in-patients-with-differentiated-thyroid-cancer
#19
Leonardo Bandeira, Rosália do Prado Padovani, Ana Luiza Ticly, Adriano Namo Cury, Nilza Maria Scalissi, Marília Martins Silveira Marone, Carolina Ferraz
OBJECTIVES: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of response to therapy in these patients. A retrospective chart review of patients with differentiated thyroid cancer (DTC) who underwent RIT after surgery and were followed for at least 1 year, was carried out. SUBJECTS AND METHODS: Patients were classified according to the dynamic risk stratification 1 year after initial treatment...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29410129/non-small-cell-lung-carcinoma-with-diffuse-co-expression-of-thyroid-transcription-factor-1-and-%C3%AE-np63-p40
#20
Takuo Hayashi, Kazuya Takamochi, Yuka Yanai, Keiko Mitani, Hisashi Tomita, Kaoru Mogushi, Yoshiyuki Suehara, Fumiyuki Takahashi, Kenji Suzuki, Tsuyoshi Saito, Takashi Yao
Here, we present a case of non-small cell lung carcinoma (NSCLC) with widespread and strong nuclear immunopositivity for both thyroid transcription factor-1 (TTF-1) and ΔNp63/p40 (p40). Double immunofluorescence for TTF-1 and p40 showed co-expression of both markers in the tumor cells. Furthermore, PTEN (pHis123Asp) and TP53 (pVal272Leu) mutations were identified as possible mitogenic driver mutations by next-generation sequencing. To the best of our knowledge, this is the first case of NSCLC harboring concurrent PTEN and TP53 mutations with widespread and strong coexpression of TTF-1 and p40, which has been confirmed in the resected specimen, and only the second documented case of NSCLC with TTF-1 and p40 diffuse coexpression in the carcinoma cells from the same individual...
February 1, 2018: Human Pathology
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