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differentiated thyroid carcinoma

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https://www.readbyqxmd.com/read/29234625/insight-into-differentiated-thyroid-cancer-gross-pathological-specimen-shrinkage-and-its-influence-on-tnm-staging
#1
Alexis Lacout, Emmanuel Chamorey, Juliette Thariat, Mostafa El Hajjam, Carole Chevenet, Renaud Schiappa, Pierre Yves Marcy
Introduction: This study aimed at comparing thyroid cancer staging when taking into account the differences between the "T" assessment" using ultrasound (US) and histopathological measurements. Material and Methods: This retrospective study included all consecutive differentiated follicular thyroid cancer (DTC) and medullary thyroid cancer (MTC) patients who underwent postoperative histopathological staging assessment at a single institution. Anaplastic thyroid carcinomas were excluded from the present study...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#2
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29228842/mammary-analogue-secretory-carcinoma-of-the-thyroid-mimicking-locally-advanced-papillary-thyroid-carcinoma-a-rare-case-report
#3
Haihui Liao, Ashraf Khan, Patricia M Miron, Kristine M Cornejo
Mammary analogue secretory carcinoma (MASC) harboring ETV6 gene rearrangements was first described in the salivary gland with a relatively favorable prognosis and a possible molecular therapeutic target with pan-Trk inhibitors. Recently, primary MASC of the thyroid gland has been reported. We report a case of a 4.0 cm MASC arising from the left thyroid of a 58-year-old female with extrathyroidal extension. Initially, it was diagnosed by fine needle aspiration as suspicious for papillary thyroid carcinoma (PTC) and subsequently called a poorly differentiated carcinoma on resection...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29221164/inhibition-of-x-linked-inhibitor-of-apoptosis-protein-suppresses-tumorigenesis-and-enhances-chemosensitivity-in-anaplastic-thyroid-carcinoma
#4
Yao Liu, Bing Zhang, Tiefeng Shi, Huadong Qin
Anaplastic thyroid carcinoma (ATC) is one of the most lethal carcinoma with a poor prognosis; however, molecular mechanisms underlying the aggressiveness of ATC remain unclear. Our goal was to examine the expression of X-linked inhibitor of apoptosis protein (XIAP) in ATC, as well as its role in ATC tumorigenesis. This is a retrospective study of ATC patients from the Second Affiliated Hospital of Harbin Medical University during June 2003 to October 2013. The expression of XIAP in tumor specimens of ATC patients was examined by immunohistochemical staining...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206325/growing-incidence-of-thyroid-carcinoma-in-recent-years-factors-underlying-overdiagnosis
#5
REVIEW
Alvaro Sanabria, Luiz P Kowalski, Jatin P Shah, Iain J Nixon, Peter Angelos, Michelle D Williams, Alessandra Rinaldo, Alfio Ferlito
There is an increasing incidence of well-differentiated thyroid cancer worldwide. Much of the increase is secondary to increased detection of small, low-risk tumors, with questionable clinical significance. This review addresses the factors that contribute to the increasing incidence and considers environmental, and patient-based and clinician-led influences. Articles addressing the causes of the increased incidence were critically reviewed. A complex interplay of environmental, medical, and social pressures has resulted in increased awareness of the thyroid disease risk, increased screening of thyroid cancers, and increased diagnosis of thyroid cancers...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29201169/p63-inhibits-cd44-cd24-cell-proliferation-and-chemoresistance-in-papillary-thyroid-carcinoma-cells
#6
Jing-Jing Guo, Hong-Shun Xu, Gang Wu, Zhen-Yu Ma
Thyroid cancer typically has a good prognosis; however, the risks of recurrence and chemoresistance associated with thyroid cancer remain a cause for concern. Papillary thyroid carcinoma (PTC) comprises 80% of all cases of thyroid carcinoma. A previous study reported that cluster of differentiation (CD) 44+/CD24- PTC cells may contribute to PTC recurrence and chemoresistance; however, the underlying molecular mechanisms remain elusive. In the present study, CD44+/CD24- cells were isolated from the TPC-1 PTC cell line and biological function assays revealed that CD44+/CD24- cells were significantly more proliferative and chemoresistant compared with CD44-/CD24- cells...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29197967/effects-of-nutraceuticals-on-anaplastic-thyroid-cancer-cells
#7
Lorenzo Allegri, Francesca Rosignolo, Catia Mio, Sebastiano Filetti, Federica Baldan, Giuseppe Damante
PURPOSE: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated. METHODS: Two ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays...
December 2, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29195126/stimulation-of-interferon-stimulated-gene-20-by-thyroid-hormone-enhances-angiogenesis-in-liver-cancer
#8
Syuan-Ling Lin, Sheng-Ming Wu, I-Hsiao Chung, Yang-Hsiang Lin, Ching-Ying Chen, Hsiang-Cheng Chi, Tzu-Kang Lin, Chau-Ting Yeh, Kwang-Huei Lin
Thyroid hormone, 3,3',5-triiodo-l-thyronine (T3), mediates several physiological processes, including embryonic development, cellular differentiation and cell proliferation, via binding to its nuclear thyroid receptors (TR). Previous microarray and Chromatin immunoprecipitation (ChIP)-on-ChIP analyses have revealed that interferon-stimulated gene 20 kDa (ISG20), an exoribonuclease involved in the antiviral function of interferon, is up-regulated by T3 in HepG2-TR cells. However, the underlying mechanisms of ISG20 action in tumor progression remain unknown to date...
November 28, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29181146/metastatic-prostate-adenocarcinoma-to-intradural-foramen-magnum
#9
Halil Olgun Peker, Nural Cafer Celik, Ulas Cikla, Mustafa K Baskaya
Intradural metastatic tumors are rarely reported in foramen magnum (FM), including cases of melanoma, pituitary carcinoma, thyroid carcinoma, and prostate carcinoma metastases. We report a 68-year-old male who presented with right-sided headache, progressive swallowing difficulty requiring gastrostomy tube and hoarseness over the course of 1 year. Images revealed a heterogeneous, contrast-enhancing lesion in the FM that compressed the anterior aspect of the medulla and upper spinal cord. Although metastatic tumor was considered in differential diagnosis, presumptive diagnosis was FM meningioma due to lack of bone destruction or sclerosis on CT and T2W isointense and T1W hypointense appearance on MRI...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29180096/differentiating-merkel-cell-carcinoma-of-lymph-nodes-without-a-detectable-primary-skin-tumor-from-other-metastatic-neuroendocrine-carcinomas-the-electhip-criteria
#10
Thibault Kervarrec, Julia Zaragoza, Pauline Gaboriaud, Amélie Le Gouge, Agnès Beby-Defaux, Yannick Le Corre, Eva Hainaut-Wierzbiecka, Francois Aubin, Guido Bens, Patrick Michenet, Hervé Maillard, Antoine Touzé, Mahtab Samimi, Serge Guyétant
BACKGROUND: Merkel cell carcinoma MCC) can present as a cutaneous tumor or a lymph node without primary tumor MCCWP). MCCWP can be misinterpreted on histologic examination as lymph node metastasis LNM) from other neuroendocrine carcinomas LNMNECs). However, this distinction is crucial for therapeutic management. OBJECTIVE: To determine the discriminative criteria for differential diagnosis between MCCWP, LNM from cutaneous MCC and LNMNECs. METHODS: Clinical, morphologic, immunohistochemical data expression of cytokeratin AE1/AE3, 7, 19, 20; chromogranin A, thyroid transcription factor-1 [TTF-1]) and presence of Merkel Cell Polyomavirus MCPyV) immunohistochemistry and PCR) were compared in patients with MCCWP n=17), LNM from cutaneous MCC n=11) and LNMNEC n=20: lung, n=8; thyroid, n=7; digestive tract, n=3; other, n=2)...
November 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29179642/a-follow-up-strategy-for-patients-with-excellent-response-to-initial-therapy-for-differentiated-thyroid-carcinoma-less-is-better
#11
MinJi Jeon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Tae Yong Kim, Won Bae Kim, YoungKee Shong, Won Gu Kim
BACKGROUND: The risk of recurrence in patients with differentiated thyroid cancer (DTC) can be estimated based on their response to initial therapy. The aim of this study is to evaluate adequate follow-up strategy for DTC patients with excellent response by assessing the characteristics of structural recurrence. METHODS: This historical cohort study included 1359 DTC patients who had excellent response to initial therapy after total thyroidectomy with radioactive iodine remnant ablation...
November 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29178507/is-doppler-ultrasonography-of-value-for-the-differentiation-between-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-and-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-iefvptc
#12
Pedro Weslley Rosario
Recently, the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) received the name "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) and was no longer considered "cancer".1 Furthermore, the treatment recommendations for differentiated thyroid cancer no longer apply to NIFTP, which is sufficiently treated by lobectomy only.1 The probability that a thyroid nodule corresponds to NIFTP has become of great interest in clinical practice, since it would at least influence the extent of surgery...
November 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29174934/primary-lesions-that-may-imitate-metastatic-tumors-histologically-a-selective-review
#13
REVIEW
Mark R Wick
Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones...
November 17, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29168459/p40-thyroid-transcription-factor-1-immunohistochemistry-a-useful-panel-to-characterize-non-small-cell-lung-carcinoma-not-otherwise-specified-nsclc-nos-category
#14
Ritika Walia, Deepali Jain, Karan Madan, Mehar C Sharma, Sandeep R Mathur, Anant Mohan, Venkateswaran K Iyer, Lalit Kumar
BACKGROUND & OBJECTIVES: Accurate histopathological subtyping of non-small cell lung carcinoma (NSCLC) is essential for targeted therapeutic agents. Immunohistochemistry (IHC) is helpful in identification of different tumour subtypes. In this study two marker approaches, one each for glandular and squamous cell differentiation was applied to maximize the proportion of accurately subtyped NSCLC not otherwise specified (NOS) tumours on small biopsy samples. METHODS: Two hundred and sixty three consecutive lung biopsies of primary lung carcinoma were prospectively studied...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168186/adipokines-and-inflammation-markers-and-risk-of-differentiated-thyroid-carcinoma-the-epic-study
#15
Laure Dossus, Silvia Franceschi, Carine Biessy, Anne-Sophie Navionis, Ruth C Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Agnès Fournier, Renee T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni Peppa, Rosario Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Raul Zamora-Ros, María-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sánchez, Jose Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Maria Nilsson, Julie A Schmidt, Kay-Tee Khaw, Konstantinos K Tsilidis, Dagfinn Aune, Elio Riboli, Sabina Rinaldi
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IL-10 and TNF-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29163685/expression-of-cancer-testis-antigens-mage-a-mage-c1-gage-and-ctag1b-in-benign-and-malignant-thyroid-diseases
#16
Daniel Hardy Melo, Rui Celso Martins Mamede, Luciano Neder, Wilson Araújo Silva, Mateus Camargo Barros-Filho, Luiz Paulo Kowalski, Clóvis Antonio Lopes Pinto, Marco Antônio Zago, David Livingstone Alves Figueiredo, Achim A Jungbluth
Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29162220/clinicopathologic-predictive-factors-of-cervical-lymph-node-metastasis-in-differentiated-thyroid-cancer
#17
Ronghao Sun, Hua Zhang, Kun Liu, Jinchuan Fan, Guojun Li, Xicheng Song, Chao Li
BACKGROUND: Cervical lymph node metastasis (LNM) has been proven to be a predictor for locoregional recurrence in differentiated thyroid carcinoma (DTC). Clinicopathological features could be effective predictive factors for central and lateral LNM of DTC, and provide references to surgeons for cervical neck dissection. METHODS: Retrospective analysis of clinicopathological data was performed on 420 patients who underwent initial surgery from 2010 to 2015. RESULTS: The incidence of central and lateral LNM was calculated...
November 18, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29158505/dynamic-profile-of-differentiated-thyroid-cancer-in-male-and-female-patients-with-thyroidectomy-during-2000-2013-in-china-a-retrospective-study
#18
Hui-Xian Yan, Ping Pang, Fu-Lin Wang, Wen Tian, Yu-Kun Luo, Wei Huang, Guo-Qing Yang, Nan Jin, Li Zang, Jin Du, Jian-Ming Ba, Jing-Tao Dou, Yi-Ming Mu, Zhao-Hui Lyu
The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors of differentiated thyroid carcinoma (DTC) in Chinese patients. A total of 7385 consecutive thyroid cancer patients who underwent thyroidectomy were retrospectively reviewed. 4087 (55.3%) were diagnosed as benign and the other (3298, 44.7%) were as malignant. DTC accounted for 97.6% in the malignant tumor. More single nodules turned out to be DTC in male compared to multiple nodules (46...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157630/the-first-postoperative-stimulated-serum-thyroglobulin-is-a-prognostic-factor-for-thyroid-microcarcinomas
#19
Isabela de Oliveira Amui, José Vicente Tagliarini, Emanuel C Castilho, Mariângela de Alencar Marques, Yoshio Kiy, José Eduardo Corrente, Gláucia M F S Mazeto
INTRODUCTION: Endogenous thyroid-stimulating hormone-stimulated thyroglobulin collected after total thyroidectomy is a useful predictor of better prognosis in patients with differentiated thyroid carcinomas in general, but studies with microcarcinomas are scarce. OBJECTIVE: To assess whether the first postoperative stimulated thyroglobulin measurement is a prognostic factor in patients with microcarcinoma. METHODS: The medical data of 150 differentiated thyroid carcinoma patients were studied retrospectively, and 54 (36%) cases with microcarcinoma were selected...
October 31, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29151906/hbme-1-expression-in-differentiated-thyroid-carcinoma-and-its-correlation-with-the-ultrasonic-manifestation-of-thyroid
#20
Jiwei Qiao, Chunyu Li, Yuying Zhang, Shuangyan Wang, Shan Gao
We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (papillary carcinoma group) and follicular differentiated thyroid carcinoma (follicular carcinoma group) to investigate the differences in expression of HBME-1...
December 2017: Oncology Letters
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