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differentiated thyroid carcinoma

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https://www.readbyqxmd.com/read/29690556/fine-needle-aspiration-cytology-for-neck-masses-in-childhood-an-illustrative-approach
#1
REVIEW
Consolato Sergi, Aneesh Dhiman, Jo-Ann Gray
The primary indication of fine-needle aspiration cytology of the head and neck region is a thyroid nodule or a mass located in the cervical area or the head. Although a thyroid nodule may raise the suspicion of malignancy, less than one in 20 cases results in a carcinoma. In addition, the list of differential diagnoses is quite different according to the age of the patient. A number of benign lesions, such as branchial cysts, sialadenosis, and sialoadenitis are often seen in childhood and youth. The malignant lesions that are on the top of the list of a pediatric mass of the head and neck (H&N) region include rhabdomyosarcoma, neuroblastoma, and papillary carcinoma of the thyroid gland...
April 22, 2018: Diagnostics
https://www.readbyqxmd.com/read/29688947/impact-of-patient-age-and-histological-type-on-radioactive-iodine-avidity-of-recurrent-lesions-of-differentiated-thyroid-carcinoma
#2
Kenichi Nakanishi, Toyone Kikumori, Noriyuki Miyajima, Yuko Takano, Sumiyo Noda, Dai Takeuchi, Shingo Iwano, Yasuhiro Kodera
BACKGROUND: Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. The present study was conducted to evaluate the impact of age and histological type on the RAI avidity of recurrent lesions of DTC...
April 23, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29672887/young-age-is-associated-with-increased-rates-of-residual-recurrent-pediatric-differentiated-thyroid-carcinoma
#3
Sarah Hampson, Derek Stephens, Jonathan D Wasserman
OBJECTIVE: Differentiated thyroid carcinoma is rare in young children. There are conflicting data as to whether disease in this age group differs from that in adolescents and specifically, if it is more aggressive. Current practice guidelines do not differentiate treatment between these groups, but speculate that differences may exist. We sought to compare clinical features, treatment and outcomes between children (<12 years) and adolescents (12-18 years) with thyroid nodules and thyroid malignancy over a 20 year period...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29664794/positive-surgical-margins-in-favorable-stage-differentiated-thyroid-cancer
#4
Catherine E Mercado, Peter A Drew, Christopher G Morris, Peter T Dziegielewski, William M Mendenhall, Robert J Amdur
OBJECTIVE: The significance of positive margin in favorable-stage well-differentiated thyroid cancer is controversial. We report outcomes of positive-margin patients with a matched-pair comparison to a negative-margin group. MATERIALS AND METHODS: A total of 25 patients with classic-histology papillary or follicular carcinoma, total thyroidectomy +/- node dissection, stage T1-3N0-1bM0, positive surgical margin at primary site, adjuvant radioactive iodine (I-131), and age older than 18 years were treated between 2003 and 2013...
April 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29663333/prognostic-significance-of-gross-extrathyroidal-extension-invading-only-strap-muscles-in-differentiated-thyroid-carcinoma
#5
S Y Park, H I Kim, J-H Kim, J S Kim, Y L Oh, S W Kim, J H Chung, H W Jang, T H Kim
BACKGROUND: In the eighth edition of the AJCC staging system for differentiated thyroid carcinoma (DTC), minimal extrathyroidal extension (ETE) is no longer a determinant of T3 category. Instead, gross ETE invading only strap muscles has been designated as a new T3b category. The long-term prognosis of patients with DTC and gross ETE invading only strap muscles was investigated. METHODS: This was a retrospective analysis of patients who underwent thyroidectomy between 1996 and 2005...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29662562/the-predictive-values-of-lesion-size-f-18-fdg-avidity-and-i-131-avidity-for-the-clinical-outcome-of-i-131-treatment-in-patients-with-metastatic-differentiated-thyroid-carcinoma-only-in-the-lung
#6
Joon Ho Choi, Byung Hyun Byun, Ilhan Lim, Hansol Moon, Jihyun Park, Kyoung Jin Chang, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
Purpose: We aimed to evaluate the prognostic values of radiography, F-18 FDG PET, and I-131 whole body scans in patients with lung-only metastasis from differentiated thyroid carcinoma (DTC). Methods: Between 1998 and 2013, we included 31 patients (F: 26, M: 5) with lung-only metastasis from DTC who had been treated with I-131 and underwent PET. Lung metastasis was categorized according to the size (macronodular ≥1.0 cm vs. micronodular <1.0 cm), FDG avidity (avid vs...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29659324/montelukast-attenuates-radioactive-i131-induced-pulmonary-damage-on-rats
#7
Arif Osman Tokat, Aylin Akbulut, Deniz Billur, Gokhan Koca, Pinar Bayram, Serdar Kuru, Sezgin Karasu, Suheyla Aydogmus, Hüseyin Cakmak, Sengul Ozmert, Meliha Korkmaz
PURPOSE: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas, however, I131 also accumulates in non-thyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29651624/in-papillary-thyroid-carcinoma-expression-by-immunohistochemistry-of-braf-v600e-pd-l1-and-pd-1-is-closely-related
#8
Yanhua Bai, Ting Guo, Xiaozheng Huang, Qi Wu, Dongfeng Niu, Xinqiang Ji, Qin Feng, Zhongwu Li, Kennichi Kakudo
Immune checkpoint inhibitor therapies targeting PD-L1/PD-1 have been shown to be effective in treating several types of human cancer. In papillary thyroid carcinoma (PTC), little is known about the expression of PD-L1/PD-1 in the tumor microenvironment or its potential correlation with BRAF V600E mutation status. In this study, we examined the expression of PD-L1, PD-1, and BRAF V600E in PTC by immunohistochemistry and investigated the clinical significance of expression status. We studied the expression of PD-L1, PD-1, and BRAF V600E by immunohistochemical staining in 110 cases of PTC with a diameter > 1 cm...
April 12, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29650525/flushing-disorders-associated-with-gastrointestinal-symptoms-part-1-neuroendocrine-tumors-mast-cell-disorders-and-hyperbasophila
#9
REVIEW
Vaibhav Rastogi, Devina Singh, Joseph J Mazza, Dennis Yang, Dipendra Parajuli, Steven H Yale
Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands...
April 12, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29642647/erbb1-and-erbb2-positive-medullary-thyroid-carcinoma-a-case-report
#10
Michele Minuto, Emanuela Varaldo, Gianluca Marcocci, Amleto de Santanna, Ermanno Ciccone, Katia Cortese
Medullary thyroid carcinomas (MTCs) are rare thyroid tumors occurring in both sporadic and hereditary forms, whose pathogenesis is related to RET proto-oncogene alterations. MTCs originate from parafollicular cells, which produce calcitonin that represents the biochemical activity of MTC. Total thyroidectomy is the main treatment for MTC and often cures patients with confined diseases. In the presence of metastasis, the therapeutic approach depends on the rate of disease progression. We report a case of a 54-year-old female with a single, incidentally discovered, thyroid nodule of 1 cm, classified as suspicious MTC after a stimulation test with intravenous (iv) calcium...
April 10, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29626249/molecular-markers-in-well-differentiated-thyroid-cancer
#11
REVIEW
Anil K D'Cruz, Richa Vaish, Abhishek Vaidya, Iain J Nixon, Michelle D Williams, Vincent Vander Poorten, Fernando López, Peter Angelos, Ashok R Shaha, Avi Khafif, Alena Skalova, Alessandra Rinaldo, Jennifer L Hunt, Alfio Ferlito
PURPOSE: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. This review covers the fundamental role of the signaling pathways and genetic changes involved in thyroid carcinogenesis. The current literature on the prognostic significance of these markers is also described...
April 6, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29625265/network-based-meta-analysis-in-the-identification-of-biomarkers-for-papillary-thyroid-cancer
#12
Hengqiang Zhao, Hehe Li
Papillary thyroid carcinoma (PTC) has been increasing across the world with incomplete understanding of its pathogenesis. We aimed to investigate gene alterations and biomarkers contributing to PTC development. A total of five eligible microarray datasets including 94 PTC and 81 normal thyroid samples were included to identify gene expression signatures. Using integrative meta-analysis of expression data (INMEX) program, we identified a total of 2699 differentially expressed genes (DEGs) (1333 overexpressed and 1366 underexpressed genes) in PTC relative to normal thyroid samples...
April 3, 2018: Gene
https://www.readbyqxmd.com/read/29624700/sarcomatoid-pilomatrix-carcinoma
#13
Angel Fernandez-Flores, David S Cassarino
Pilomatrical (pilomatrix) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only four cases previously published. We present an additional case on the hand of a 78 year-old man which appeared as a 6 mm hyperkeratotic ─focally ulcerated─ plaque. A shave biopsy demonstrated a dermal infiltrative neoplasm, composed of markedly atypical-appearing basaloid cells with focal necrotic/ghost cells, as well as an intimately associated population of atypical oval to spindle-shaped cells...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29619107/unusual-presentation-of-differentiated-thyroid-cancer-metastasis
#14
Haissan Iftikhar, Mubasher Ikram, Adnan Yar Muhammad, Karim Rizwan Nathani
Introduction  The rates of thyroid cancers are on a rise, especially well-differentiated thyroid cancers. This could be partly due to newer diagnostic modalities, like high-resolution ultrasound, that can pick up smaller lesions. Differentiated thyroid cancers with distant metastases are not common, and even rarer is the initial presentation with complaints not related to the neck. Objectives  The objective of this series was to study and report the unusual cases of patients with differentiated thyroid cancer with distant metastasis...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29618671/prognostic-value-of-the-8-th-tumor-node-metastasis-classification-for-follicular-carcinoma-and-poorly-differentiated-carcinoma-of-the-thyroid-in-japan
#15
Yasuhiro Ito, Akira Miyauchi, Mitsuyoshi Hirokawa, Masatoshi Yamamoto, Hitomi Oda, Hiroo Masuoka, Hisanori Sasai, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Akihiro Miya
Follicular thyroid carcinoma (FTC), a form of differentiated thyroid carcinoma, is the second most common malignancy arising from thyroid follicular cells. Recently, the tumor-node-metastasis (TNM) classification for differentiated thyroid carcinoma was revised from the 7th to the 8th edition. The diagnostic criteria for poorly differentiated carcinoma (PDC) were also updated in the latest World Health Organization (WHO) classification. In this study, we investigated whether these changes are appropriate for accurately predicting prognosis...
April 4, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29608439/quantitative-analysis-of-the-benefits-and-risk-of-thyroid-nodule-evaluation-in-patients-%C3%A2-70-years-old
#16
Zhihong Wang, Chirag M Vyas, Olivia Van Benschoten, Matt A Nehs, Francis D Moore, Ellen Marqusee, Jeffrey F Krane, Matthew I Kim, Howard T Heller, Atul A Gawande, Mary C Frates, Peter M Doubilet, Gerard M Doherty, Nancy L Cho, Edmund S Cibas, Carol B Benson, Justine A Barletta, Ann Marie Zavacki, P Reed Larsen, Erik K Alexander, Trevor E Angell
BACKGROUND: In older patients, thyroid nodules are frequently detected and referred for evaluation, though usually prove to be benign disease or low-risk cancer. Therefore, management should be guided not solely by malignancy risk, but also by the relative risks of any intervention. Unfortunately, few such data are available for patients ≥70 years old. METHODS: All consecutive patients ≥70 years old assessed by ultrasound (US) and fine-needle aspiration (FNA) between 1995 and 2015 were analyzed...
April 2, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29596551/thyroidectomy-practice-after-implementation-of-the-2015-american-thyroid-association-guidelines-on-surgical-options-for-patients-with-well-differentiated-thyroid-carcinoma
#17
Nir Hirshoren, Kira Kaganov, Jeffrey M Weinberger, Benjamin Glaser, Beatrice Uziely, Ido Mizrahi, Ron Eliashar, Haggi Mazeh
Importance: The recommended extent of surgery for well-differentiated thyroid carcinoma has been modified considerably in the updated 2015 American Thyroid Association guidelines published in January 2016. To date, the changes in clinical practice after publication of these new guidelines have not been demonstrated. Objective: The aim of this study was to evaluate clinical practice changes associated with implementation of the updated guidelines on the surgical procedure rates of total thyroidectomy, thyroid lobectomy, and completion thyroidectomy at a single tertiary medical center...
March 29, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29594049/positron-emission-tomography-pet-and-pet-ct-in-thyroid-cancer-a-systematic-review-and-meta-analysis
#18
Friederike Schütz, Christine Lautenschläger, Kerstin Lorenz, Johannes Haerting
Background: Positron emission tomography (PET) and PET/CT are functional imaging methods that are widely used in diagnostic procedures in oncology. Objectives: The objective of this study was to assess the patient-relevant benefit of PET or PET/CT in patients with thyroid cancer based on a literature review and meta-analysis. Methods: A systematic review including studies that had been published until December 2013 was performed. To be included, studies had to prospectively investigate patients with thyroid cancer in a clinical setting of staging, restaging, or diagnosing tumour recurrence...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29588604/primary-mucinous-carcinoma-of-thyroid-gland-with-prominent-signet-ring-cell-differentiation-a-case-report-and-review-of-the-literature
#19
Jian Wang, Qie-Re Guli, Xiao-Cui Ming, Hai-Tao Zhou, Yong-Jie Cui, Yue-Feng Jiang, Di Zhang, Yang Liu
Purpose: This study reports a case of primary mucinous carcinoma of the thyroid gland with signet-ring-cell differentiation, and reviews the literature to evaluate its real incidence and the prognosis of these patients. Patients and methods: A 74-year-old Chinese woman, presenting with a mass in the right lobe of thyroid gland, came to the hospital. Computed tomography revealed a mass in the right lobe of the thyroid gland, accompanied with right neck lymphadenectasis and airway deviation caused by tumor compression...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29584698/loss-of-one-or-two-patz1-alleles-has-a-critical-role-in-the-progression-of-thyroid-carcinomas-induced-by-the-ret-ptc1-oncogene
#20
Mario Monaco, Giuseppe Palma, Michela Vitiello, Anna Capiluongo, Barbara D'Andrea, Emilia Vuttariello, Antonio Luciano, Laura Cerchia, Gennaro Chiappetta, Claudio Arra, Alfredo Fusco, Monica Fedele
POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) is an emerging cancer-related gene that is downregulated in different human malignancies, including thyroid cancer, where its levels gradually decrease going from papillary thyroid carcinomas (PTC) to poorly differentiated and undifferentiated highly aggressive anaplastic carcinomas (ATC). The restoration of PATZ1 expression in thyroid cancer cells reverted their malignant phenotype by inducing mesenchymal-to-epithelial transition, thus validating a tumor suppressor role for PATZ1 and suggesting its involvement in thyroid cancer progression...
March 27, 2018: Cancers
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