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https://www.readbyqxmd.com/read/28936912/epidural-hematoma-development-contralateral-to-dura-after-lumbar-transforaminal-epidural-steroid-injection
#1
Semih Gungor, Rohit Aiyer
AIM: To illustrate the anatomical and pathophysiological risks of epidural hematoma formation, other than direct needle trauma, after lumbar transforaminal epidural steroid injection in the setting of severe central canal stenosis. CASE REPORT: This case report presents the development of an epidural hematoma after lumbar transforaminal epidural steroid injection in a patient who has anatomical risk factor of severe lumbar spinal stenosis. The anatomic location of epidural hematoma was at the injected level, but on the contralateral side of the dura at a distance from the needle path...
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28934875/natural-type-ii-collagen-hydrogel-fibrin-sealant-and-adipose-derived-stem-cells-as-a-promising-combination-for-articular-cartilage-repair
#2
Mariana Lazarini, Pedro Bordeaux-Rego, Renata Giardini-Rosa, Adriana S S Duarte, Mariana Ozello Baratti, Alessandro Rozim Zorzi, João Batista de Miranda, Carlos Lenz Cesar, Ângela Luzo, Sara Teresinha Olalla Saad
Objective Articular cartilage is an avascular tissue with limited ability of self-regeneration and the current clinical treatments have restricted capacity to restore damages induced by trauma or diseases. Therefore, new techniques are being tested for cartilage repair, using scaffolds and/or stem cells. Although type II collagen hydrogel, fibrin sealant, and adipose-derived stem cells (ASCs) represent suitable alternatives for cartilage formation, their combination has not yet been investigated in vivo for focal articular cartilage defects...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28931824/boosted-regeneration-and-reduced-denervated-muscle-atrophy-by-neuroheal-in-a-pre-clinical-model-of-lumbar-root-avulsion-with-delayed-reimplantation
#3
David Romeo-Guitart, Joaquim Forés, Xavier Navarro, Caty Casas
The "gold standard" treatment of patients with spinal root injuries consists of delayed surgical reconnection of nerves. The sooner, the better, but problems such as injury-induced motor neuronal death and muscle atrophy due to long-term denervation mean that normal movement is not restored. Herein we describe a preclinical model of root avulsion with delayed reimplantation of lumbar roots that was used to establish a new adjuvant pharmacological treatment. Chronic treatment (up to 6 months) with NeuroHeal, a new combination drug therapy identified using a systems biology approach, exerted long-lasting neuroprotection, reduced gliosis and matrix proteoglycan content, accelerated nerve regeneration by activating the AKT pathway, promoted the formation of functional neuromuscular junctions, and reduced denervation-induced muscular atrophy...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930957/clot-dynamics-and-mortality-the-ma-r-ratio
#4
Stephanie A Savage, Ben L Zarzaur, Timothy H Pohlman, Brian L Brewer, Louis J Magnotti, Martin A Croce, Garrett H Lim, Ali C Martin
INTRODUCTION: The coagulopathy of trauma, illustrated by a short R-time, is common and well understood. The physiology behind this may be early thrombin burst with rapid clot formation. Rapid consumption of fibrinogen, however, may result in weak clot and substrate depletion, resulting in low MA. While these characteristics are interesting, utilizing thromboelastography (TEG) to identify those at risk of subsequent bleeding diathesis, especially in those who do not demonstrate early signs of physiologic derangement, is challenging...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28929807/splenic-artery-embolization-in-blunt-trauma-a-single-center-retrospective-comparison-of-the-use-of-gelatin-sponge-versus-coils
#5
Pasteur Rasuli, Bardia Moosavi, Gordon J French, William Petrcich, Ian Hammond
OBJECTIVE: The purpose of this study was to compare the efficacy of gelatin sponge with that of coils for splenic artery embolization in the treatment of blunt splenic injury. MATERIALS AND METHODS: A single-center retrospective review was performed with the records of 63 patients (45 men, 18 women; mean age, 45.5 years; range, 16-84 years) with blunt splenic injury treated at a tertiary care trauma center by splenic artery embolization with gelatin sponge (n = 30 patients) or metallic coils (n = 33 patients) between 2005 and 2014...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28929059/incidence-of-facial-nerve-canal-dehiscence-in-primary-and-revision-cholesteatoma-surgery
#6
Mohammad Faramarzi, Sareh Roosta
The aim of this retrospective study was to determine the incidence of facial canal dehiscence (FCD) in primary and revision cholesteatoma surgery in a tertiary referral center. Moreover, our second goal was to identify association between FCD and other intra-operative pathological findings in a group of patients with cholesteatoma surgery. Inclusion criteria were primary and revision canal wall up and canal wall down tympanomastoidectomy in patients who suffers from chronic otitis media (COM) with cholesteatoma...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28926192/testing-of-a-bioactive-moldable-bone-graft-substitute-in-an-infected-critically-sized-segmental-defect-model
#7
Matt E Brown, Yuan Zou, Rebecca Peyyala, Sarandeep S Huja, Larry L Cunningham, Todd A Milbrandt, Thomas D Dziubla, David A Puleo
Large infected bone defects, often resulting from high energy traumas, are difficult to treat due to their variability in complexity and location. Standard treatment for infected bone defects begins with a protocol that includes a series of debridements in conjunction with an extended course of systemic antibiotics. Only after the infection has been eliminated will repair of the defect commence, typically with implantation of autologous bone. To address some of the shortcomings of the standard treatment methods, such as serial procedures, limited grafting material, and the need for a second surgical site for autologous bone, a sequential, dual drug-releasing, moldable, calcium sulfate-based bone graft substitute was developed previously...
September 19, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28921846/improvement-of-polytrauma-management-quality-inspection-of-a-newly-introduced-course-concept
#8
Ingo Gräff, Shahab Ghamari, Sylvia Schacher, Procula Glien, Rolf Fimmers, Torsten Baehner, Se-Chan Kim
RATIONALE, AIMS, AND OBJECTIVES: A systematic literature search for training course concepts for care of severely injured and severely ill patients respecting improvement of process and outcome yielded little data. For several years, the University Hospital of Bonn has hosted a shock-room management course which, on the one hand, communicates human factor aspects and, on the other hand, pursues interdisciplinary and interprofessional team training. The Bonn shock-room management course (BSM-course®) differs from other courses in both format and principles...
September 17, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28921700/low-dose-fractionated-irradiation-promotes-axonal-regeneration-beyond-reactive-gliosis-and-facilitates-locomotor-function-recovery-after-spinal-cord-injury-in-beagle-dogs
#9
Qiang Zhang, Ying Xiong, Bo Zhu, Bifeng Zhu, Daishi Tian, Wei Wang
Injury to the adult central nervous system (CNS) results in the formation of glial scar tissues. Glial scar-induced failure of regenerative axon pathfinding may limit axon regrowth beyond the lesion site and cause incorrect reinnervation and dystrophic appearance of stalled growth after CNS trauma. Glial scars also upregulate chondroitin sulfate proteoglycans (CSPGs) and expression of proinflammatory factor(s) that form a barrier to axonal regeneration. Therefore, interventions for glial scarring are an attractive strategy for augmenting axonal sprouting and regeneration and overcoming the physical and molecular barriers impeding functional repair...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28918953/-superficial-temporal-artery-pseudoaneurysm-2-cases
#10
D Lebas, P Modiano, T Wiart
BACKGROUND: Pseudoaneurysm of the superficial temporal artery causes tumefaction in the temporal region. Herein, we report two cases. PATIENTS AND METHODS: Case 1 : a 32-year-old man presented with a slightly pulsatile nodular formation measuring 2 cm in the right temporal region that had appeared nine months after traumatic injury. A diagnosis of superficial temporal artery pseudoaneurysm was considered. Excision was performed with ligation of the afferent and efferent artery...
September 14, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28915647/necroptosis-as-a-potential-therapeutic-target-in-multiple-organ-dysfunction-syndrome
#11
Yao-Li Cui, Li-Hua Qiu, Shi-Yong Zhou, Lan-Fang Li, Zheng-Zi Qian, Xian-Ming Liu, Hui-Lai Zhang, Xiu-Bao Ren, Yong-Qiang Wang
PURPOSE: To investigate how necroptosisis, i.e. programmed necrosis, is involved in MODS, and to examine whether Nec-1, a specific necroptosis inhibitor, ameliorates multiorgan injury in MODS. EXPERIMENTAL DESIGN: A model of MODS was established in six-week old SD rats using fracture trauma followed by hemorrhage. Control animals received sham surgery. Cell death form and necrosome formation were measured by fluorescence-activated cell sorting and western blotting...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913385/closed-internal-degloving-of-the-flank
#12
Lindsay F Remy, Jacob Azurdia, Ashraf Fansa, Nabil A Ebraheim
Originally described in 1853 by Dr. Morel-Lavellee, closed internal degloving injuries represent an important, although uncommon, source of morbidity in trauma patients. These injuries are typically the result of a shearing or crushing force that traumatically separates the skin and subcutaneous tissue from the underlying fat. This results in disruption of perforating blood vessels and lymphatics, leading to hematoma/seroma formation. We describe two cases in which industrial crush injuries resulted in lumbar transverse process fracture...
July 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28902777/operative-versus-nonoperative-management-of-blunt-pancreatic-trauma-in-children-a-systematic-review
#13
Ezra Y Koh, Daan van Poll, J Carel Goslings, Olivier R Busch, Erik A Rauws, Matthijs W Oomen, Marc G Besselink
The aim of this study was to compare operative versus nonoperative management of blunt pancreatic trauma in children. A systematic literature search was performed. Studies including children with blunt pancreatic injuries classified according to the American Association for the Surgery of Trauma classification were included. The primary outcome was pseudocyst formation. After screening 526 studies, 23 studies with 928 patients were included. Sufficient data were available for 674 patients (73%). Of 309 patients with grade I or II injuries, 258 (83%) were initially managed nonoperatively with a 96% success rate...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28898722/influence-of-gamma-and-electron-beam-sterilization-on-the-stability-of-a-premixed-injectable-calcium-phosphate-cement-for-trauma-indications
#14
Kieran A Murray, Maurice N Collins, Regina P O'Sullivan, Guang Ren, Declan M Devine, Alan Murphy, Jarosław Sadło, Carol O'Sullivan, Brian McEvoy, Olivier Vrain, Cathriona O'Neill, Gerard Insley
Premixed calcium phosphate cements (CPC's) are becoming the material of choice for injectable cements as a result of their effective delivery to the target implantation site. For orthopaedic use, it is of vital importance that the attributes of these CPC's are not compromised by irradiation sterilization. Therefore, the aim of this study is to determine the influence of irradiation sterilization on a range of premixed CPC's, with an emphasis on improving product shelf life through the use of optimal packaging configurations and annealing steps...
September 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28893682/effects-of-flavonoids-incorporated-biological-macromolecules-based-scaffolds-in-bone-tissue-engineering
#15
REVIEW
S Preethi Soundarya, V Sanjay, A Haritha Menon, S Dhivya, N Selvamurugan
Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to address the unmet need for bone augmentation, bone tissue engineering and regenerative medicine have evolved in the recent years. Bone tissue engineering harnesses novel scaffolds, stem cells and biological factors that promise enhanced and more reliable bone formation. Increasingly phytochemicals, particularly flavonoids are gaining renowned interest lately for their therapeutic potential on bone...
September 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28885215/hyperspectral-imaging-as-a-novel-diagnostic-tool-in-microcirculation-of-wounds
#16
Georg Daeschlein, Inga Langner, Thomas Wild, Sebastian von Podewils, Claudia Sicher, Thomas Kiefer, Michael Jünger
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic wound management it is of utmost importance to realize and parametrize wound bed perfusion to verify actual, and plan further treatment by noninvasive diagnostics. Up to now monitoring is based on visual inspection of wounds as conventionally practiced over more than decades. The main problems of visual inspection are the lack of standardization and comparability because of interindividual variations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28883008/nasogastric-tube-knotting-a-rare-and-potentially-overlooked-complication-among-healthcare-professionals
#17
Vijay Chavda, Tariq Alhammali, Joanna Farrant, Leena Naidu, Saleem El-Rabaa
Nasogastric tube placement is a common procedure performed in surgical and medical specialities. The occurrence of knot formation is perhaps one of the least well-recognised complications associated with its usage. We present a case of nasogastric tube knotting to remind colleagues of this rare but important complication. A 75-year-old woman with adhesional bowel obstruction was admitted under the general surgery team. A wide bore nasogastric tube was inserted for drainage and decompression. Although placement of the tube was deemed to be successful, there was no drainage of gastric content evident...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28880362/cold-platelets-for-trauma-associated-bleeding-regulatory-approval-accreditation-approval-and-practice-implementation-just-the-tip-of-the-iceberg
#18
James R Stubbs, Sheryl A Tran, Richard L Emery, Scott A Hammel, De Anna L Haugen, Martin D Zielinski, Scott P Zietlow, Donald Jenkins
BACKGROUND: Laboratory and clinical evidence suggest that cold-stored platelets (CS-PLTs) might be preferable to room temperature platelets (RT-PLTs) for active bleeding. Ease of prehospital use plus potential hemostatic superiority led our facility to pursue approval of CS-PLTs for actively bleeding trauma patients. STUDY DESIGN AND METHODS: From November 18, 2013, through October 8, 2015, correspondence was exchanged between our facility, the AABB, and the US Food and Drug Administration (FDA)...
September 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28879314/protective-effects-of-remifentanil-against-h2o2-induced-oxidative-stress-in-human-osteoblasts
#19
Ji-Young Yoon, Do-Wan Kim, Eun-Jung Kim, Bong-Soo Park, Ji-Uk Yoon, Hyung-Joon Kim, Jeong-Hoon Park
BACKGROUND: Bone injury is common in many clinical situations, such as surgery or trauma. During surgery, excessive reactive oxygen species (ROS) production decreases the quality and quantity of osteoblasts. Remifentanil decreases ROS production, reducing oxidative stress and the inflammatory response. We investigated remifentanil's protective effects against H2O2-induced oxidative stress in osteoblasts. METHODS: To investigate the effect of remifentanil on human fetal osteoblast (hFOB) cells, the cells were incubated with 1 ng/ml of remifentanil for 2 h before exposure to H2O2...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28874183/urethral-calculi-with-a-urethral-fistula-a-case-report-and-review-of-the-literature
#20
Mingqiang Zeng, Fanchang Zeng, Zhao Wang, Ruizhi Xue, Liang Huang, Xuyu Xiang, Zhi Chen, Zhengyan Tang
BACKGROUND: To explore and summarize the reasons why urethral calculi cause a urethral fistula. CASE PRESENTATION: We retrospectively studied 1 patient in Xiangya hospital and all relevant literature published in English between 1989 and 2015. The patients (including those reported in the literature) were characterized by age, origin, location of calculus, size of calculus, fistulous track, and etiological factors. Most of urethral calculi associated with a urethral fistula were native generated...
September 6, 2017: BMC Research Notes
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