keyword
MENU ▼
Read by QxMD icon Read
search

trauma formation

keyword
https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#1
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29773986/flavopiridol-protects-bone-tissue-by-attenuating-rankl-induced-osteoclast-formation
#2
Zi'ang Hu, Yilei Chen, Lijiang Song, Jasper H N Yik, Dominik R Haudenschild, Shunwu Fan
Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyclin-dependent kinase 9 (CDK9) is the major regulator of inflammation, as CDK9 inhibitor flavopiridol effectively suppress injury-induced inflammatory response. The objective of this study was to investigate the underlying mechanism through which flavopiridol regulates bone resorption...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29772857/-posterior-spinal-canal-decompression-with-screw-fixation-and-reconstruction-of-three-vertebral-column-for-thoracolumbar-burst-fractures-complicated-with-nerve-injury
#3
Li-Yong Wu, Xue-Mei Huang, Yue Wang, Zhao-Bo Yang, Sheng-Hui Su, Chun Wang
OBJECTIVE: To explore the feasibility and clinical effect of posterior spinal canal decompression with pedicle screw fixation and reconstruction of anterior and middle vertebral column for thoracolumbar burst fractures complicated with nerve injury. METHODS: A total of 36 patients with thoracolumbar burst fractures treated from March 2011 to April 2016 were enrolled in the retrospective study. There were 20 males and 16 females, aged from 21 to 52 years old with an average of 37...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29770226/massive-haemorrhagic-blister-formation-following-total-knee-arthroplasty
#4
Aadhar Sharma, Padmanabhan Subramanian, Sunil Shah, Mohan Remani, Muhammad Shahid
Skin blistering following trauma is not uncommon; however, large haemorrhagic bullous blisters following total knee arthroplasty is relatively rare and not widely documented in the literature.
May 2018: JRSM Open
https://www.readbyqxmd.com/read/29758989/the-double-hazard-of-bleeding-and-thrombosis-in-hemostasis-from-a-clinical-point-of-view-a-global-assessment-by-rotational-thromboelastometry-rotem
#5
Olga Meltem Akay
Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29756791/individual-and-group-cognitive-processing-therapy-effectiveness-across-two-veterans-affairs-posttraumatic-stress-disorder-treatment-clinics
#6
Kristen E Lamp, Kimberly M Avallone, Kelly P Maieritsch, Katherine R Buchholz, Sheila A M Rauch
OBJECTIVE: In accordance with Veterans Affairs (VA) policy, VA posttraumatic stress disorder (PTSD) clinics offer evidence-based treatments including cognitive processing therapy (CPT). To facilitate access to care, CPT is offered in both group and individual formats in many VA PTSD clinics. Group and individual delivery of CPT have been directly compared in active duty samples, but these findings have not been extended to VA populations. The present article directly compares the effectiveness of group and individual CPT with a written trauma account (CPT+A) across two VA PTSD clinics...
May 14, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29755271/clinical-radiological-and-histopathological-characteristics-of-surgically-removed-orbital-hematic-cysts-a-case-series
#7
Hind M Alkatan, Mohammad Al Otaibi, Azza M Y Maktabi, Hamad Aljaedi, Sahar M Elkhamary, Yasser Al-Faky, Adel H Alsuhaibani
Background: Hematic cyst is a rare orbital condition that has a wide range of clinical presentation and is characterized pathologically by lack of endothelial lining. Purpose: To correlate clinical and radiological features of hematic cysts, to tissue diagnosis, and investigate the possible etiology behind this condition, its relation to trauma and other interesting histopathological findings. Methods: Retrospective case series at King Khaled Eye Specialist Hospital (KKESH) and King Abdulaziz University Hospital (KAUH) of all orbital lesions with tissue findings supporting the clinical and/or radiological diagnosis of hematic cyst...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29753790/il-17-promotes-scar-formation-by-inducing-macrophage-infiltration
#8
Julei Zhang, Qiao Qiao, Mengdong Liu, Ting He, Jihong Shi, Xiaozhi Bai, Yijie Zhang, Yan Li, Weixia Cai, Shichao Han, Hao Guan, Dahai Hu
Trauma or burn injuries that affect the deep dermis often produce a hypertrophic scar, which limits patients' joint movement and generates an aesthetic problem. Inflammation is believed to be one of the main pathogenic mechanisms. We found that IL-17 was increased in scar tissues from patients with hypertrophic scar compared with normal skin. Recombinant mouse IL-17 was subcutaneously injected into mice that underwent full-thickness excision surgery to investigate the role of IL-17 in scar formation. Mice stimulated with IL-17 showed aggravated fibrogenesis, delayed wound healing, and increased inflammation...
May 11, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29747055/multiple-brain-abscess-after-professional-tooth-cleaning-case-report-and-literature-review
#9
Massimo Viviano, Serena Cocca
Brain abscess (BA) is an encapsulated infection and can be the consequence of head and cranio-maxillo-facial surgery or trauma, or may be secondary to cavernous thrombophlebitis, but is most frequently due to hematogenous septic dissemination from an adjacent site of infection, such as the paranasal sinuses, middle ear or oral cavity. We report a rare and unfortunate case of multiple BA caused by dental procedures in a young man with undiagnosed patent foramen ovale (PFO). Simple routine dental procedures, such as tooth brushing and professional oral hygiene, can predispose to life-threatening conditions...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29743351/survival-of-syngeneic-and-allogeneic-ipsc-derived-neural-precursors-after-spinal-grafting-in-minipigs
#10
Jan Strnadel, Cassiano Carromeu, Cedric Bardy, Michael Navarro, Oleksandr Platoshyn, Andreas N Glud, Silvia Marsala, Jozef Kafka, Atsushi Miyanohara, Tomohisa Kato, Takahiro Tadokoro, Michael P Hefferan, Kota Kamizato, Tetsuya Yoshizumi, Stefan Juhas, Jana Juhasova, Chak-Sum Ho, Taba Kheradmand, PeiXi Chen, Dasa Bohaciakova, Marian Hruska-Plochan, Andrew J Todd, Shawn P Driscoll, Thomas D Glenn, Samuel L Pfaff, Jiri Klima, Joseph Ciacci, Eric Curtis, Fred H Gage, Jack Bui, Kazuhiko Yamada, Alysson R Muotri, Martin Marsala
The use of autologous (or syngeneic) cells derived from induced pluripotent stem cells (iPSCs) holds great promise for future clinical use in a wide range of diseases and injuries. It is expected that cell replacement therapies using autologous cells would forego the need for immunosuppression, otherwise required in allogeneic transplantations. However, recent studies have shown the unexpected immune rejection of undifferentiated autologous mouse iPSCs after transplantation. Whether similar immunogenic properties are maintained in iPSC-derived lineage-committed cells (such as neural precursors) is relatively unknown...
May 9, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29740988/suppression-of-the-interleukin-1%C3%A3-induced-inflammatory-response-of-human-chang-liver-cells-by-acute-and-subacute-exposure-to-alcohol-an-in-vitro-study
#11
Katharina Mörs, Shinwan Kany, Jason-Alexander Hörauf, Nils Wagner, Claudia Neunaber, Mario Perl, Ingo Marzi, Borna Relja
AIM: To evaluate protective immunosuppressive dose and time-dependent effects of ethanol in an in vitro model of acute inflammation in human Chang liver cells. METHOD: The study was performed in 2016 and 2017 in the research laboratory of the Department of Trauma, Hand and Reconstructive Surgery, the University Hospital of the Goethe-University Frankfurt. Chang liver cells were stimulated with either interleukin (IL)-1β or IL-6 and subsequently treated with low-dose ethanol (85 mmol/L) or high-dose ethanol (170 mmol/L) for one hour (acute exposure) or 72 hours (subacute exposure)...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29734459/-application-of-vacuum-wound-therapy-with-split-thickness-skin-grafts-in-the-head-and-neck-area
#12
Julia Thierauf, Paul Severin Wiggenhauser, Thomas Karl Hoffmann, Jens Greve, Marc Scheithauer, Johannes Adrian Veit
OBJECTIVE: In vacuum wound therapy (VAC) a negative pressure can continuously clean effusions and enhance the formation of granulation tissue significantly. In visceral, trauma and burns surgery this technique is used frequently in critical wounds. In the head and neck area there is limited experience and publications. Especially in the combined use of split-thickness-skin grafts (STSG) and VAC there is no published evidence. MATERIAL AND METHODS: A retrospective database analysis was done and resulted in 36 single VAC therapies in 13 patients...
May 7, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29731908/calcific-myonecrosis-mimicking-soft-tissue-sarcoma-a-case-report
#13
Yuichiro Ukon, Takaaki Tanaka, Shigenori Nagata, Hiroki Hagizawa, Yoshinori Imura, Hironari Tamiya, Kazuya Oshima, Norifumi Naka, Yasuaki Aoki, Shigeyuki Kuratsu
Calcific myonecrosis is a rare soft tissue condition. The first case was reported in 1960, however, the precise pathophysiology of calcific myonecrosis remains unclear. The disease was thought to arise from compartment syndrome within a confined space resulting in necrosis and fibrosis, subsequent repeated intralesional hemorrhage, mass enlargement and calcification. Several previous reports have described calcific myonecrosis, which include the formation of calcific myonecrosis after a prolonged period of post trauma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731193/thirty-years-of-submental-intubation-a-review
#14
REVIEW
D Lim, B C Ma, R Parumo, P Shanmuhasuntharam
Submental intubation has been used as an alternative to conventional intubation in the field of oral and maxillofacial surgery since its introduction by Francisco Hernández Altemir in 1986. A review of submental intubation was performed using data from all case reports, case-series, and prospective and retrospective studies published between 1986 and 2016. The indications, variations in incision length, incision sites, types of endotracheal tube used, methods of exteriorization, and complications were recorded and analyzed...
May 3, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29719839/a-randomized-controlled-trial-on-intra-abdominal-irrigation-during-emergency-trauma-laparotomy-time-for-yet-another-paradigm-shift
#15
Hassan Mashbari, Mohannad Hemdi, Kevin L Chow, James C Doherty, Gary J Merlotti, Steven L Salzman, Eduardo Smith Singares
Objective: To determine the optimal volume of abdominal irrigation that will prevent surgical site infections (both deep and superficial), eviscerations and fistula formations; and improve 30-day mortality in trauma patients. Methods: We conducted a three-arm parallel clinical superiority randomized controlled trial comparing different volumes of effluent (5, 10 and 20 liters) used in trauma patients (both blunt and penetrating) age 14 and above undergoing an emergency laparotomy between April 2002 and July 2004 in a busy urban Level 1 trauma center...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29719605/-in-vivo-safety-and-efficacy-testing-of-a-thermally-triggered-injectable-hydrogel-scaffold-for-bone-regeneration-and-augmentation-in-a-rat-model
#16
Abbey A Thorpe, Christine Freeman, Paula Farthing, Jill Callaghan, Paul V Hatton, Ian M Brook, Chris Sammon, Christine Lyn Le Maitre
Bone loss resulting from degenerative diseases and trauma is a significant clinical burden which is likely to grow exponentially with the aging population. In a number of conditions where pre-formed materials are clinically inappropriate an injectable bone forming hydrogel could be beneficial. The development of an injectable hydrogel to stimulate bone repair and regeneration would have broad clinical impact and economic benefit in a variety of orthopedic clinical applications. We have previously reported the development of a Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel delivery system, loaded with hydroxyapatite nanoparticles (HAPna), which was capable of inducing osteogenic differentiation of mesenchymal stem cells (MSCs) without the need for additional growth factors in vitro ...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29714150/cinnamon-polyphenol-extract-exerts-neuroprotective-activity-in-traumatic-brain-injury-through-modulation-of-nfr2-and-cytokine-expression
#17
Burak Yulug, Ertugrul Kilic, Serdar Altunay, Cenk Ersavas, Cemal Orhan, Arman Dalay, Nurhan Sahin, Mehmet Tuzcu, Vijaya Juturu, Kazim Sahin
INTRODUCTION: Cinnamon cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for treatment of different disease conditions which are associated with inflammation and oxidative stress. Despite many preclinical studies showing the anti-oxidative, anti-inflammatory effects of CN, the underlying mechanisms in signaling pathways via which cinnamon protects the brain after brain trauma remained largely unknown. However, there is still no preclinical study delineating the possible molecular mechanism of neuroprotective effects cinnamon polyphenol extractin TBI...
April 30, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29707009/the-effect-of-canal-preparation-with-four-different-rotary-systems-on-formation-of-dentinal-cracks-an-in-vitro-evaluation
#18
Elham Khoshbin, Zakiyeh Donyavi, Erfan Abbasi Atibeh, Ghodratollah Roshanaei, Faranak Amani
Introduction: Endodontic rotary systems may result in dentinal cracks. They may propagate to vertical root fracture that compromises the outcome of endodontic treatment. This study aimed to compare Neolix and Reciproc (single-file systems), Mtwo and ProTaper (conventional rotary systems) in terms of dentinal crack formation in root canal walls. Methods and Materials: This in vitro study was conducted on 110 extracted human single-rooted teeth. The teeth were randomly divided into four experimental groups ( n =25) for root canal preparation with Neolix, Reciproc, Mtwo and ProTaper systems and two control groups ( n =5)...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29704727/how-do-skeletons-with-hiv-present-a-study-on-the-identified-cal-milano-cemetery-skeletal-collection
#19
Lucie Biehler-Gomez, Antonio Cabrini, Danilo De Angelis, Cristina Cattaneo
With the Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS) pandemic, the study of HIV/AIDS on bones has become of pivotal interest for research in bone pathologies, forensic applications (especially in the matter of identification when confronted to antemortem data) and medical purposes. In this paper, we document and discuss the macroscopic lesions found on the skeletons of nine individuals with known HIV, including four with known AIDS, coming from the identified CAL Milano Cemetery Skeletal Collection...
April 24, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29703488/clinical-characteristics-of-disseminated-intravascular-coagulation-in-patients-with-solid-and-hematological-cancers
#20
Marcel Levi
Malignant disease can be complicated by disseminated intravascular coagulation (DIC). DIC is defined as systemic intravascular triggering of coagulation (resulting in intravascular fibrin clot formation) and concurrent depletion of clotting factors and platelets (increasing the risk of hemorrhage). The clinical presentation of DIC in patients with cancer has usually a less fulminant presentation than DIC that may accompany other underlying disorders, such as sepsis and trauma. A more insidious, but also more protracted, diffuse activation of coagulation can proceed without any symptom...
April 2018: Thrombosis Research
keyword
keyword
100626
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"