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https://www.readbyqxmd.com/read/28211911/three-dimensional-printing-of-calcium-sulfate-and-mesoporous-bioactive-glass-scaffolds-for-improving-bone-regeneration-in-vitro-and-in-vivo
#1
Xin Qi, Peng Pei, Min Zhu, Xiaoyu Du, Chen Xin, Shichang Zhao, Xiaolin Li, Yufang Zhu
In the clinic, bone defects resulting from infections, trauma, surgical resection and genetic malformations remain a significant challenge. In the field of bone tissue engineering, three-dimensional (3D) scaffolds are promising for the treatment of bone defects. In this study, calcium sulfate hydrate (CSH)/mesoporous bioactive glass (MBG) scaffolds were successfully fabricated using a 3D printing technique, which had a regular and uniform square macroporous structure, high porosity and excellent apatite mineralization ability...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210902/deletion-of-mammalian-sterile-20-like-kinase-1-attenuates-neuronal-loss-and-improves-locomotor-function-in-a-mouse-model-of-spinal-cord-trauma
#2
Pan-Feng Wang, Da-Yuan Xu, Yuntong Zhang, Xiao-Bin Liu, Yan Xia, Pan-Yu Zhou, Qing-Ge Fu, Shuo-Gui Xu
Neuronal cell death following spinal cord injury (SCI) is an important contributor to neurological deficits. The purpose of our work was to delineate the function of mammalian sterile 20-like kinase 1 (Mst1), a pro-apoptotic kinase and key mediator of apoptotic signaling, in the pathogenesis of an experimental mouse model of SCI. Male mice received a mid-thoracic spinal contusion injury, and it was found that phosphorylation of Mst1 at the injured site was enhanced significantly following SCI. Furthermore, when compared to the wild-type controls, Mst1-deficient mice displayed improved locomotor function by increased Basso mouse scale score...
February 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28198794/open-tibia-shaft-fractures-and-soft-tissue-coverage-the-effects-of-management-by-an-orthopedic-trauma-microsurgical-team
#3
James VandenBerg, Daniel Osei, Martin I Boyer, Michael J Gardner, William M Ricci, Amanda Spraggs-Hughes, Christopher McAndrew
OBJECTIVES: To compare the timing of soft-tissue (flap) coverage and occurrence of complications before and after the establishment of an integrated orthopedic trauma/microsurgical team. DESIGN: Retrospective Cohort StudySETTING:: A single level 1 trauma centerPATIENTS:: 28 subjects (13 pre- and 15 post-integration) with open tibia shaft fractures (OTA/AO 42A, 42B, 42C) treated with flap coverage between January 2009 and March 2015. INTERVENTION: Flap coverage for open tibia shaft fractures treated before ("pre-integration") and after ("post-integration") implementation of an integrated orthopedic trauma/microsurgical team...
February 11, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28195605/the-implications-of-inaccuracy-comparison-of-coding-in-heterotopic-ossification-and-associated-trauma
#4
Matt Fury, Mitchell John, Stuart Schexnayder, Harry Molligan, Olivia Lee, Peter Krause, Vinod Dasa
Retrospective studies using large databases serve a major purpose in providing evidence in the current literature. However, the quality of medical coding is highly variable. This retrospective cohort study aimed to evaluate the documentation regarding the diagnosis of heterotopic ossification (HO) and the implications it may have for conducting retrospective research using electronic medical records (EMRs). A retrospective chart review using the EMR was performed to identify all patients with a diagnosis of HO within 7 university-affiliated hospital facilities...
February 13, 2017: Orthopedics
https://www.readbyqxmd.com/read/28194322/sural-artery-perforator-flap-with-posterior-tibial-neurovascular-decompression-for-recurrent-foot-ulcer-in-leprosy-patients
#5
Hossam El-Din Ali Ismail, Mohamed Hassan El Fahar
Introduction: The sensory loss and alteration of the shape of the foot make the foot liable to trauma and pressure, and subsequently cause more callus formation, blisters, and ulcers. Foot ulcers usually are liable to secondary infection as cellulitis or osteomyelitis, and may result in amputations. Foot ulcers are a major problem and a major cause of handicaps in leprosy patients. The current study is to present our clinical experience and evaluate the use of sural flap with posterior tibial neurovascular decompression (PTND) in recurrent foot ulcers in leprosy patients...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/28193459/epileptiform-activity-and-behavioral-arrests-in-mice-overexpressing-the-calcium-channel-subunit-%C3%AE-2%C3%AE-1
#6
Leonardo C Faria, Feng Gu, Isabel Parada, Ben Barres, Z David Luo, David A Prince
: The alpha2delta-1 subunit (α2δ-1) of voltage-gated calcium channels is a receptor for astrocyte-secreted thrombospondins that promote developmental synaptogenesis.Alpha2delta-1 receptors are upregulated in models of injury-induced peripheral pain and epileptogenic neocortical trauma associated with an enhancement of excitatory synaptic connectivity. These results lead to the hypothesis that overexpression of α2δ-1 alone in neocortex of uninjured transgenic (TG) mice might result in increased excitatory connectivity and consequent cortical hyperexcitability and epileptiform activity...
February 10, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28188004/introducing-a-morbidity-and-mortality-conference-in-rwanda
#7
Egide Abahuje, Innocent Nzeyimana, Jennifer L Rickard
OBJECTIVES: To assess the structure, format, and educational features of a morbidity and mortality (M&M) conference in Rwanda. To determine factors associated with adverse events and to define opportunities for improvement. DESIGN: Retrospective, descriptive study of all cases presented at a surgical M&M conference over a 1-year period. Cases were reviewed for factors associated with adverse events and opportunities for improvement. Factors were characterized as delays in presentation, delays in diagnosis, delays in the operating room, errors in judgment, technical errors, advanced disease, and missing resources or malnutrition...
February 7, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28187475/concomitant-sternal-fracture-in-flail-chest-an-analysis-of-21-741-polytrauma-patients-from-the-traumaregister-dgu%C3%A2
#8
Stefan Schulz-Drost, Sebastian Krinner, Andreas Langenbach, Pascal Oppel, Rolf Lefering, Dominic Taylor, Friedrich F Hennig, Andreas Mauerer
Background Isolated sternal fractures (SFs) rarely show complications, but their influence in a thorax trauma of the seriously injured still remains unclear. Methods A retrospective analysis of the TraumaRegister DGU(®) was performed involving the years 2009 to 2013 (Injury Severity Score [ISS] ≥ 16, primary admission to a trauma center). Cohort formation: Unilateral and bilateral flail chest (FC) injuries with and without a concomitant SF, respectively. Results In total, 21,741 patients (25% female) met the inclusion criteria, with 3,492 (16...
February 10, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28186446/de-novo-avm-formation-following-venous-sinus-thrombosis-and-prior-avm-resection-in-adults-report-of-2-cases
#9
Siyu Shi, Raghav Gupta, Justin M Moore, Christoph J Griessenauer, Nimer Adeeb, Rouzbeh Motiei-Langroudi, Ajith J Thomas, Christopher S Ogilvy
Brain arteriovenous malformations (AVMs) are traditionally considered congenital lesions, arising from aberrant vascular development during the intrauterine period. Rarely, however, AVMs develop in the postnatal period. Individual case reports of de novo AVM formation in both pediatric and adult patients have challenged the traditional dogma of a congenital origin. Instead, for these cases, a dynamic picture is emerging of AVM growth and development, initially triggered by ischemic and/or traumatic events, coupled with genetic predispositions...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28185382/autogenous-bone-block-grafting-provides-facial-implant-tissue-stability-long-term
#10
Fernando Verdugo, Agurne Uribarri, Antonio D'Addona
BACKGROUND: Mucosal recession (MR) and bone loss can compromise anterior implant esthetics. PURPOSE: To evaluate tissue stability and clinical outcomes of anterior implants augmented with autogenous block transplants long-term. MATERIALS AND METHODS: This prospective cross-sectional clinical study analyzed facial tissue recession of anterior implants augmented with autogenous bone blocks and compared them to adjacent teeth in forty patients 52 months post-augmentation...
February 10, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28179972/septic-shock-of-unknown-origin-a-case-report-of-a-pseudoaneurysm-of-the-mitral-aortic-intervalvular-fibrosa
#11
Julio Gil, Hugo Antunes, Bruno Marmelo, Luis Abreu, Maria Luisa Goncalves, Luis Ferreira Dos Santos, Jose Costa Cabral
Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare complication of infective endocarditis and trauma, particularly of aortic valve surgery. Clinical symptoms are usually unspecific and generally due to complications. Transesophageal echocardiography (TEE) is the most commonly used exam to diagnose P-MAIVF. The main echocardiographic feature is the presence of a cavity communicating with the left ventricular outflow tract that expands during systole and collapses during diastole. Most frequent complications are formation of a fistulous tract and compression of adjacent structures...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28177588/a-retrospective-study-of-isolated-fractures-of-the-alveolar-process-in-the-permanent-dentition
#12
Maja Marotti, Kurt Alois Ebeleseder, Gerold Schwantzer, Stefanie Jauk
BACKGROUND/AIM: There is a lack of studies of fractures of the alveolar process (FAP). Only five were published in the last fifty years. The aim of this study was to analyze the risk of pulp necrosis and infection (PN), pulp canal obliteration (PCO), infection-related root resorption (IRR), ankylosis-related resorption (ARR), marginal bone loss (MBL), and tooth loss (TL) as well as to identify the possible risk factors for teeth involved in an isolated alveolar process fracture. In the second part, any late complications of the involved teeth were reported in patients who responded to a follow-up examination...
February 8, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28169594/keratin-hydrogel-enhances-in-vivo-skeletal-muscle-function-in-a-rat-model-of-volumetric-muscle-loss
#13
Juliana A Passipieri, Hannah B Baker, Mevan Siriwardane, Mary Ellenburg, Manasi Vadhavkar, Justin M Saul, Seth Tomblyn, Luke Burnett, George Joseph Christ
Volumetric Muscle Loss (VML) injuries exceed the considerable intrinsic regenerative capacity of skeletal muscle resulting in permanent functional and cosmetic deficits. VML and VML-like injuries occur in military and civilian populations, due to trauma and surgery as well as a host of congenital and acquired diseases/syndromes. Current therapeutic options are limited, and new approaches are needed for more complete functional regeneration of muscle. A potential solution is human hair derived keratin (KN) biomaterials that may have significant potential for regenerative therapy...
February 7, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28167239/6-gingerol-protects-intestinal-barrier-from-ischemia-reperfusion-induced-damage-via-inhibition-of-p38-mapk-to-nf-%C3%AE%C2%BAb-signalling
#14
Yanli Li, Bin Xu, Ming Xu, Dapeng Chen, Yongjian Xiong, Mengqiao Lian, Yuchao Sun, Zeyao Tang, Li Wang, Chunling Jiang, Yuan Lin
Intestinal ischemia reperfusion (I/R) injury caused by severe trauma, intestinal obstruction, and operation is one of the tough challenges in clinic. 6-Gingerol (6G), a main active ingredient of ginger, is found to have anti-microbial, anti-inflammatory, anti-oxidative, and anti-cancer activities. The present study was designed to characterize the potential protective effects of 6G on rat intestinal I/R injury and reveal the correlated mechanisms. Rat intestinal I/R model was established with clamping the superior mesenteric artery (SMA) and 6G was intragastrically administered for three consecutive days before I/R injury...
February 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28167142/molecular-landscape-of-arthrofibrosis-microarray-and-bioinformatic-analysis-of-the-temporal-expression-of-380-genes-during-contracture-genesis
#15
Mark E Morrey, Matthew P Abdel, Scott M Riester, Amel Dudakovic, Andre J van Wijnen, Bernard F Morrey, Joaquin Sanchez-Sotelo
PURPOSE: Inflammatory changes are suspected in the pathophysiology of arthrofibrosis formation and require early molecular examination.Here, we assessed the hypothesis that early inflammatory genes are related to arthrofibrosis by ascertaining gene expression during the early stages of contracture genesis in an animal model. METHODS: Joint trauma was incited surgically in a cohort of rabbits (n=36) knees followed by immobilization in a model of contracture.Six groups of 6 rabbits were sacrificed at multiple time points (0, 6, 12, 24, 72h and 2weeks)...
February 3, 2017: Gene
https://www.readbyqxmd.com/read/28165797/strategies-of-enhancing-bone-regenerate-formation-in-distraction-osteogenesis
#16
Mohammad Mesfer Alzahrani, Emad Anam, Saad M AlQahtani, Asim M Makhdom, Reggie C Hamdy
Distraction osteogenesis (DO) is a commonly used technique in multiple orthopaedic specialties, including trauma, oncology and pediatrics. This technique aims to produce new bone formation in the distraction gap in a controlled manner. The issue with this technique has been the high risk of complications, one of which is poor regenerate formation during the distraction process. Although several factors (including patient and operative factors) and techniques (including surgical, mechanical and pharmacological) have been described to ensure successful regenerate formation during the process of DO, these factors are sometimes difficult to control clinically...
February 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28165778/delayed-biloma-formation-in-a-patient-with-blunt-liver-injury-after-low-velocity-trauma
#17
Jonathan Kam, Thomas J Hugh, Anthony Joseph
No abstract text is available yet for this article.
February 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28165057/a-novel-indication-of-platonin-a-therapeutic-immunomodulating-medicine-on-neuroprotection-against-ischemic-stroke-in-mice
#18
Joen-Rong Sheu, Zhih-Cherng Chen, Thanasekaran Jayakumar, Duen-Suey Chou, Ting-Lin Yen, Hsing-Ni Lee, Szu-Han Pan, Chih-Hsuan Hsia, Chih-Hao Yang, Cheng-Ying Hsieh
Thrombosis and stroke are major causes of disability and death worldwide. However, the regular antithrombotic drugs may have unsatisfactory results and side effects. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers and some acute inflammation. Here, we explored the neuroprotective effects of platonin against middle cerebral artery occlusion (MCAO)-induced ischemic stroke in mice. Platonin(200 μg/kg) substantially reduced cerebral infarct volume, brain edema, neuronal cell death and neurological deficit scores, and improved the MCAO-reduced locomotor activity and rotarod performance...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28151823/orbital-inclusion-cyst-formation-3-years-after-penetrating-orbital-trauma
#19
Kristen E Dunbar, Michael Kazim
No abstract text is available yet for this article.
February 1, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28142178/impact-of-abdominal-follow-up-sonography-in-trauma-patients-without-abdominal-parenchymal-organ-lesion-or%C3%A2-free-intraabdominal-fluid-in-whole-body-computed-tomography
#20
Emmanuel Schneck, Christian Koch, Mara Borgards, Martin Reichert, Andreas Hecker, Christian Heiß, Winfried Padberg, Enrique Alejandre-Lafont, Rainer Röhrig, Gabriele Anja Krombach, Markus Weigand, Michael Bernhard, Fritz Christian Roller
Purpose Patients suffering from severe blunt abdominal trauma are challenging because of their need for accurate diagnostic imaging and fast therapeutic action. Whole-body computed tomography (WBCT) is highly sensitive and represents the gold standard in the trauma room diagnostic setting. The aim of our study was to investigate the impact and therapy relevance of abdominal follow-up sonography (AFS) as part of the tertiary trauma survey (TTS) in patients without abdominal parenchymal organ lesions or free abdominal fluid in initial WBCT...
February 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
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