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Hematopoietic cell transplant

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https://www.readbyqxmd.com/read/29471034/microbiome-host-interactions-in-hematopoietic-stem-cell-transplant-recipients
#1
Tessa Andermann, Jonathan Peled, Christine Ho, Pavan Reddy, Marcie Riches, Rainer Storb, Takanori Teshima, Marcel van den Brink, Amin Alousi, Sophia Balderman, Patrizia Chiusolo, William Clark, Ernst Holler, Alan Howard, Leslie Kean, Andrew Koh, Philip McCarthy, John McCarty, Mohamad Mohty, Ryotaro Nakamura, Katy Rezvani, Brahm Segal, Bronwen Shaw, Elizabeth Shpall, Anthony Sung, Daniela Weber, Jennifer Whangbo, John Wingard, William Wood, Miguel-Angel Perales, Robert Jenq, Ami Bhatt
No abstract text is available yet for this article.
February 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29470425/major-histocompatibility-complex-and-hematopoietic-stem-cell-transplantation-beyond-the-classical-hla-polymorphism
#2
REVIEW
Alice Bertaina, Marco Andreani
Allogeneic hematopoietic stem cell transplantation (HSCT) represents a curative treatment for many patients with hematological malignant or non-malignant disorders. Evaluation of potential donors for HSCT includes a rigorous assessment of the human leukocyte antigens (HLA) match status of family members, and the identification of suitable unrelated donors. Genes encoding transplantation antigens are placed both within and outside the major histocompatibility complex (MHC). The human MHC is located on the short arm of chromosome 6 and contains a series of genes encoding two distinct types of highly polymorphic cell surface glycoproteins...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29469961/relapse-and-survival-after-transplantation-for-complex-karyotype-acute-myeloid-leukemia-a-report-from-the-acute-leukemia-working-party-of-the-european-society-for-blood-and-marrow-transplantation-and-the-university-of-texas-md-anderson-cancer-center
#3
Stefan O Ciurea, Myriam Labopin, Gerard Socie, Liisa Volin, Jakob Passweg, Patrice Chevallier, Dietrich Beelen, Noel Milpied, Didier Blaise, Jan J Cornelissen, Nathalie Fegueux, Emmanuelle Polge, Piyanuch Kongtim, Gabriela Rondon, Jordi Esteve, Mohamad Mohty, Bipin N Savani, Richard E Champlin, Arnon Nagler
BACKGROUND: Despite recent advances in allogeneic hematopoietic stem cell transplantation (AHSCT), the outcome of patients who have acute myeloid leukemia (AML) with a complex karyotype (CK) remains poor. The objective of this study was to identify prognostic factors associated with post-transplantation survival in a large cohort of patients with CK AML. METHODS: In total, data on 1342 consecutively patients who underwent transplantation for CK (≥3 chromosomal abnormalities) AML were provided by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation and from the University of Texas MD Anderson Cancer Center database were included in the analysis...
February 22, 2018: Cancer
https://www.readbyqxmd.com/read/29469225/successful-hematopoietic-stem-cell-transplantation-for-osteopetrosis-using-reduced-intensity-conditioning
#4
Bella Shadur, Irina Zaidman, Adeeb NaserEddin, Elana Lokshin, Fatma Hussein, Hodaya Cohen Oron, Batia Avni, Sigal Grisariu, Polina Stepensky
BACKGROUND: Infantile malignant osteopetrosis (IMO) is an autosomal recessive condition characterized by defective osteoclast activity, with hematopoietic bone marrow transplant being the only available cure. Over the past several years, new conditioning regimes and donor options have emerged, thus extending the possibility of cure to a greater number of patients and improving the outcomes of bone marrow transplant. Here we detail the outcomes of bone marrow transplant in a cohort of 31 patients treated with a combination of fludarabine, treosulphan, thiotepa, and antithymocyte globulin...
February 22, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29469189/incorporation-of-gsta1-genetic-variations-into-a-population-pharmacokinetic-model-for-iv-busulfan-in-paediatric-hematopoietic-stem-cell-transplantation
#5
T Nava, N Kassir, M A Rezgui, C R S Uppugunduri, P Huezo-Diaz Curtis, M Duval, Y Théoret Y, L E Daudt, C Litalien, M Ansari, M Krajinovic, H Bittencourt
AIMS: To develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan imetabolism. METHODS: Busulfan concentration-time data was collected from 112 children and adolescents (median 5.4 years old, range: 0.1 to 20) who received intravenous busulfan during the conditioning regimen prior to stem cell transplantation. Weight, sex, baseline disease (malignant vs...
February 22, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29468554/sdf-1-alpha-attenuates-myocardial-injury-without-altering-the-direct-contribution-of-circulating-cells
#6
Andrew B Goldstone, Cassandra E Burnett, Jeffery E Cohen, Michael J Paulsen, Anahita Eskandari, Bryan E Edwards, Arnar B Ingason, Amanda N Steele, Jay B Patel, John W MacArthur, Judith A Shizuru, Y Joseph Woo
Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations...
February 21, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29467489/a-human-bone-marrow-mesodermal-derived-cell-population-with-hemogenic-potential
#7
Saloomeh Mokhtari, Evan Colletti, Weihong Yin, Chad Sanada, Zanetta Lamar, Paul J Simmons, Steven Walker, Colin Bishop, Anthony Atala, Esmail D Zanjani, Christopher D Porada, Graça Almeida-Porada
The presence, within the human bone marrow, of cells with both endothelial and hemogenic potential has been controversial. Herein, we identify, within the human fetal bone marrow, prior to establishment of hematopoiesis, a unique APLNR+, Stro-1+ cell population, co-expressing markers of early mesodermal precursors and/or hemogenic endothelium. In adult marrow, cells expressing similar markers are also found, but at very low frequency. These adult-derived cells can be extensively culture expanded in vitro without loss of potential, they preserve a biased hemogenic transcriptional profile, and, upon in vitro induction with OCT4, assume a hematopoietic phenotype...
February 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29467485/the-cell-fate-determinant-scribble-is-required-for-maintenance-of-hematopoietic-stem-cell-function
#8
Juliane Mohr, Banaja P Dash, Tina M Schnoeder, Denise Wolleschak, Carolin Herzog, Nuria Tubio Santamaria, Sönke Weinert, Sonika Godavarthy, Costanza Zanetti, Michael Naumann, Björn Hartleben, Tobias B Huber, Daniela S Krause, Thilo Kähne, Lars Bullinger, Florian H Heidel
Cell fate determinants influence self-renewal potential of hematopoietic stem cells. Scribble and Llgl1 belong to the Scribble polarity complex and reveal tumor-suppressor function in drosophila. In hematopoietic cells, genetic inactivation of Llgl1 leads to expansion of the stem cell pool and increases self-renewal capacity without conferring malignant transformation. Here we show that genetic inactivation of its putative complex partner Scribble results in functional impairment of hematopoietic stem cells (HSC) over serial transplantation and during stress...
January 30, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29467322/gut-microbiota-modulates-adoptive-cell-therapy-via-cd8%C3%AE-dendritic-cells-and-il-12
#9
Mireia Uribe-Herranz, Kyle Bittinger, Stavros Rafail, Sonia Guedan, Stefano Pierini, Ceylan Tanes, Alex Ganetsky, Mark A Morgan, Saar Gill, Janos L Tanyi, Frederic D Bushman, Carl H June, Andrea Facciabene
Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in the native composition of the gut microbiome or treatment with antibiotics, or by heterologous fecal transfer. Depletion of bacteria with vancomycin decreased the rate of tumor growth in mice from The Jackson Laboratory receiving ACT, whereas treatment with neomycin and metronidazole had no effect, indicating the role of specific bacteria in host response...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29466350/heart-rate-variability-markers-as-correlates-of-survival-in-recipients-of-hematopoietic-cell-transplantation
#10
Caroline Scheiber, Laura Johnston, Mary Packer, Richard Gevirtz, Katharine S Edwards, Oxana Palesh
OBJECTIVES: To assess pre-/post-transplantation changes in autonomic tone, as measured by heart rate variability (HRV), among patients undergoing hematopoietic cell transplantation (HCT) and to look at those changes as they relate to post-transplantation survival rates. 
. SAMPLE & SETTING: Data were derived from a sample of 27 English-speaking patients undergoing allogeneic or autologous HCT at Stanford University. 
. METHODS & VARIABLES: A survival analysis using the Kaplan-Meier estimator was employed to explore whether increased HRV would enhance survival probabilities over time among patients undergoing HCT...
March 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29466341/coming-of-age-with-cancer-physical-social-and-financial-barriers-to-independence-among-emerging-adult-survivors
#11
Eden Brauer, Huibrie C Pieters, Patricia A Ganz, Wendy Landier, Carol Pavlish, MarySue V Heilemann
PURPOSE: To explore the transition to self-care among a sample of emerging adult cancer survivors after hematopoietic cell transplantation (HCT). 
. PARTICIPANTS & SETTING: 18 HCT survivors who were aged 18-29 years at the time of HCT for a primary hematologic malignancy and were 8-60 months post-HCT participated in the study. The study took place in the hematology outpatient setting at City of Hope National Medical Center.
. METHODOLOGIC APPROACH: The authors conducted in-depth semistructured interviews and analyzed interview transcripts using grounded theory methodology...
March 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29465425/optimization-of-nutrition-during-allogeneic-hematologic-stem-cell-transplantation
#12
Annic Baumgartner, Katja Hoskin, Philipp Schuetz
PURPOSE OF REVIEW: Malnutrition before and during hematopoietic stem cell transplantation (HSCT) is an independent risk factor for mortality in patients undergoing hematopoietic stem cell transplantation. Yet, optimal use of nutritional support to improve outcomes remains controversial. Our aim was to do an up-to-date literature review regarding nutritional therapy in allogeneic HSCT, the neutropenic diet and the use of immunonutrients. RECENT FINDINGS: Several observational studies find malnutrition to be associated with poor outcome, increased complications and lower overall survival...
February 19, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29464898/matching-donor-and-recipient-based-on-predicted-indirectly-recognizable-human-leucocyte-antigen-epitopes
#13
REVIEW
K Geneugelijk, E Spierings
The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor-recipient compatibility. The PIRCHE algorithm determines donor-recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation...
February 21, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29464765/delay-of-alternative-antiviral-therapy-and-poor-outcomes-of-acyclovir-resistant-herpes-simplex-virus-infections-in-recipients-of-allogeneic-stem-cell-transplant
#14
Ella J Ariza-Heredia, Roy F Chemaly, Lokesh R Shahani, Ying Jang, Richard Champlin, Victor E Mulanovich
Acyclovir is commonly used to prevent and treat herpes simplex virus (HSV) reactivation after hematopoietic cell transplant (HCT), and only few reports have been published on acyclovir-resistant HSV in HCT recipients. We reviewed the medical records of patients with a microbiologic diagnosis of acyclovir-resistant HSV by plaque reduction test who received an HCT from 2002 through 2014. A total of 4028 HCTs were performed during the study period, and 18 of the recipients met the diagnostic criteria for acyclovir-resistant HSV...
February 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29463744/mhc-mismatched-mixed-chimerism-restores-peripheral-tolerance-of-noncross-reactive-autoreactive-t-cells-in-nod-mice
#15
Mingfeng Zhang, Jeremy J Racine, Qing Lin, Yuqing Liu, Shanshan Tang, Qi Qin, Tong Qi, Arthur D Riggs, Defu Zeng
Autoimmune type 1 diabetes (T1D) and other autoimmune diseases are associated with particular MHC haplotypes and expansion of autoreactive T cells. Induction of MHC-mismatched but not -matched mixed chimerism by hematopoietic cell transplantation effectively reverses autoimmunity in diabetic nonobese diabetic (NOD) mice, even those with established diabetes. As expected, MHC-mismatched mixed chimerism mediates deletion in the thymus of host-type autoreactive T cells that have T-cell receptor (TCR) recognizing (cross-reacting with) donor-type antigen presenting cells (APCs), which have come to reside in the thymus...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463563/first-in-human-phase-1-clinical-study-of-the-il-15-superagonist-complex-alt-803-to-treat-relapse-after-transplantation
#16
Rizwan Romee, Sarah Cooley, Melissa M Berrien-Elliott, Peter Westervelt, Michael R Verneris, John E Wagner, Daniel J Weisdorf, Bruce R Blazar, Celalettin Ustun, Todd E DeFor, Sithara Vivek, Lindsey Peck, John F DiPersio, Amanda F Cashen, Rachel Kyllo, Amy Musiek, András Schaffer, Milan J Anadkat, Ilana Rosman, Daniel Miller, Jack O Egan, Emily K Jeng, Amy Rock, Hing C Wong, Todd A Fehniger, Jeffrey S Miller
New therapies for patients with hematologic malignancies who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) are needed. Interleukin (IL)-15 is a cytokine that stimulates CD8+ T cell and NK cell anti-tumor responses, and we hypothesized this cytokine may augment anti-leukemia/lymphoma immunity in vivo. To test this, we performed a first-in-human multi-center phase 1 trial (ClinicalTrials.gov NCT01885897) of the IL-15 superagonist complex ALT-803 in patients who relapsed >60 days after allo-HCT...
February 20, 2018: Blood
https://www.readbyqxmd.com/read/29460229/ceftolozane-tazobactam-therapy-for-multidrug-resistant-pseudomonas-aeruginosa-infections-in-patients-with-hematologic-malignancies-and-hematopoietic-cell-transplant-recipients
#17
Morgan Hakki, James S Lewis
Multidrug-resistant (MDR) Pseudomonas aeruginosa infection causes significant mortality among patients with hematologic malignancies and hematopoietic-cell transplant recipients. Ceftolozane-tazobactam (C-T) is a novel therapeutic option for MDR-P. aeruginosa infections but clinical experience in these patients is limited. We report favorable clinical outcomes and lack of limiting toxicities using C-T monotherapy to treat invasive MDR-P. aeruginosa infections in these patient populations.
February 19, 2018: Infection
https://www.readbyqxmd.com/read/29459719/mir-142-3p-regulates-autophagy-by-targeting-atg16l1-in-thymic-derived-regulatory-t-cell-ttreg
#18
Chuanyong Zhang, Hongbing Shen, Yunjie Lu, Ji Gao, Shaopeng Zhang, Jian Gu, Hao Lu, Yongxiang Xia, Qin Zhu, Xiaofeng Qian, Feng Zhang, Keli L Hippen, Bruce R Blazar, Ling Lu, Xuehao Wang
Thymic-derived regulatory T cell (tTreg) clinical trials show therapeutic promise in the prevention of acute graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation patients. However, strategies are needed to improve tTreg proliferative ability and survival as a means to improve tTreg therapy and reduce the requirement for producing large numbers of Treg cells for adoptive tTreg transfer. Autophagy is a self-degradative process for cytosolic components, which is involved in cells death, differentiation, lymphocyte homeostasis, and tTreg function...
February 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29459712/the-e3-ubiquitin-ligase-triad1-influences-development-of-mll-ell-induced-acute-myeloid-leukemia
#19
Hao Wang, Ling Bei, Chirag A Shah, Weiqi Huang, Leonidas C Platanias, Elizabeth A Eklund
Chromosomal translocations involving the MLL1 gene characterize a poor prognosis subset of acute myeloid leukemia (AML), referred to as 11q23-AML. Transcription of the HOXA9 and HOXA10 genes is enhanced in hematopoietic stem and progenitor cells in these leukemias. We previously found the ARIH2 gene was repressed by HoxA9 in myeloid progenitors, but activated by HoxA10 during granulopoiesis. ARIH2 encodes the Triad1 protein, an anti-proliferative E3 ubiquitin ligase. In the current study, we investigate the role of Triad1 in leukemogenesis induced by an MLL1 fusion protein (Mll-Ell)...
February 20, 2018: Oncogene
https://www.readbyqxmd.com/read/29459665/a-randomized-placebo-controlled-pilot-trial-of-aprepitant-combined-with-standard-antiemetic-therapy-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-patients-undergoing-cyclophosphamide-based-conditioning-regimens-prior-to-hematopoietic-stem
#20
Joseph Bubalo, Kelsey Mulverhill, Gabrielle Meyers, Brandon Hayes-Lattin, Richard Maziarz
The aim of this study was to evaluate the safety and efficacy of aprepitant when used prophylactically to prevent nausea and vomiting during cyclophosphamide-based conditioning regimens. The primary objective of this study was to determine if there was a difference in the number of emesis-free days in patients who received aprepitant as compared to those who received placebo. This prospective, randomized, double blind, placebo-controlled study was performed in 40 adult patients who received a cyclophosphamide-containing HSCT conditioning regimen...
February 20, 2018: Bone Marrow Transplantation
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