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Siyeon Kim, Joo-Young Lee
BACKGROUND: Menthol chemically triggers cold-sensitive receptors in the skin without conductive skin cooling. We investigated the effects of menthol-induced activation of cutaneous cold receptors on the cold-induced vasodilation (CIVD) of the finger. We hypothesized that the menthol application would attenuate typical CIVD responses. METHODS: 1.5% L-menthol was fully applied over the left hand and forearm, and then, the middle finger of the left hand was immersed into 4 °C water for 30 min...
May 9, 2018: Journal of Physiological Anthropology
Gary J Hodges, Matthew M Mallette, Stephen S Cheung
Whether sympathetic withdrawal or endothelial dilators such as nitric oxide (NO) contributes to cold-induced vasodilation (CIVD) events is unclear. We measured blood flow and finger skin temperature (Tfinger ) of the index finger in nine participants during hand immersion in a water bath at 35 °C for 30 min, then at 8 °C for 30 min. Data were binned into 10 s averages for the entire 60 min protocol for laser-Doppler flux (LDF) and Tfinger . At baseline, Tfinger was 35.3 ± 0.2 °C and LDF was 227 ± 28 PU...
March 2, 2018: European Journal of Applied Physiology
Zuying Chai, Changhe Wang, Rong Huang, Yuan Wang, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, Zhuan Zhou
Action potential induces membrane depolarization and triggers intracellular free Ca2+ concentration (Ca2+ )-dependent secretion (CDS) via Ca2+ influx through voltage-gated Ca2+ channels. We report a new type of somatic exocytosis triggered by the action potential per se-Ca2+ -independent but voltage-dependent secretion (CiVDS)-in dorsal root ganglion neurons. Here we uncovered the molecular mechanism of CiVDS, comprising a voltage sensor, fusion machinery, and their linker. Specifically, the voltage-gated N-type Ca2+ channel (CaV 2...
December 20, 2017: Neuron
Lena Norrbrand, Roger Kölegård, Michail E Keramidas, Igor B Mekjavic, Ola Eiken
PURPOSE: The purpose was to examine whether associations exist between temperature responses in the fingers vs. toes and hand vs. foot during local cold-water immersion and rewarming phases. METHODS: Seventy healthy subjects (58 males, 12 females) immersed their right hand or right foot, respectively, in 8 °C water for 30 min (CWI phase), followed by a 15-min spontaneous rewarming (RW) in 25 °C air temperature. RESULTS: Temperature was lower in the toes than the fingers during the baseline phase (27...
June 2017: European Journal of Applied Physiology
Joo-Young Lee, Joonhee Park, Eunsook Koh, Seongwon Cha
The aim of the present study was to evaluate the local cold tolerance of older Korean female divers, haenyeo (N = 22) in terms of cold acclimatization and ageing. As control groups, older non-diving females (N = 25) and young females from a rural area (N = 15) and an urban area (N = 51) participated in this study. To evaluate local cold tolerance, finger cold-induced vasodilation (CIVD) during finger immersion of 4 °C water was examined. As a result, older haenyeos showed greater minimum finger temperature and recovery finger temperature than older non-diving females (P < 0...
July 2017: International Journal of Biometeorology
Aklima Khatun, Sakura Ashikaga, Hisaho Nagano, Md Abdul Hasib, Akihiro Taimura
BACKGROUND: The human thermoregulation system responds to changes in environmental temperature, so humans can self-adapt to a wide range of climates. People from tropical and temperate areas have different cold tolerance. This study compared the tolerance of Bangladeshi (tropical) and Japanese (temperate) people to local cold exposure on cold-induced vasodilation (CIVD). METHODS: Eight Bangladeshi males (now residing in Japan) and 14 Japanese males (residing in Japan) participated in this study...
2016: Journal of Physiological Anthropology
Catherine O'Brien, John W Castellani, Stephen R Muza
Mountain environments have combined stressors of lower ambient temperature and hypoxia. Cold alone can reduce finger temperature, resulting in discomfort, impaired dexterity, and increased risk of cold injury. Whether hypobaric hypoxia exacerbates these effects is unclear. To examine this, finger temperature responses to two cold water immersion tests were measured at sea level (SL, 99 kPa), 3000 m (70 kPa), and 4675 m (56 kPa) at the same air temperature (22°-23°C). Nine males sat quietly for 30 min, then completed the tests in balanced order...
September 2015: High Altitude Medicine & Biology
Joonhee Park, Joo-Young Lee
This study was conducted to investigate relationships of self-identified cold tolerance and cold-induced vasodilatation (CIVD) in the finger. Nine males and 34 females participated in the following 2 tests: a CIVD test and a self-reported survey. The CIVD test was conducted 30-min cold-water immersion (3.8 ± 0.3 °C) of the middle finger at an air temperature of 27.9 ± 0.1 °C. The self-reported questionnaire consisted of 28 questions about whole and local body cold and heat tolerances. By a cluster analysis on the survey results, the participants were divided into two groups: high self-identified cold tolerance (HSCT, n = 25) and low self-identified cold tolerance (LSCT, n = 18)...
April 2016: International Journal of Biometeorology
Christopher James Tyler, Tom Reeve, Stephen S Cheung
The present study compared the thermal responses of the finger to 0 and 8°C water immersion, two commonly used temperatures for cold-induced vasodilation (CIVD) research. On two separate and counterbalanced occasions 15 male and 15 female participants immersed their index finger in 20°C water for 5 min followed by either 0 or 8°C water for 30 min. Skin temperature, cardiovascular and perceptual data were recorded. Secondary analyses were performed between sexes and comparing 0.5, 1 and 4°C CIVD amplitude thresholds...
2015: PloS One
Matthew J Maley, Clare M Eglin, James R House, Michael J Tipton
PURPOSE: Cold injuries are more prevalent in individuals of African descent (AFD). Therefore, we investigated the effect of extremity cooling on skin blood flow (SkBF) and temperature (T sk) between ethnic groups. METHODS: Thirty males [10 Caucasian (CAU), 10 Asian (ASN), 10 AFD] undertook three tests in 30 °C air whilst digit T sk and SkBF were measured: (i) vasomotor threshold (VT) test--arm immersed in 35 °C water progressively cooled to 10 °C and rewarmed to 35 °C to identify vasoconstriction and vasodilatation; (ii) cold-induced vasodilatation (CIVD) test--hand immersed in 8 °C water for 30 min followed by spontaneous warming; (iii) cold sensitivity (CS) test--foot immersed in 15 °C water for 2 min followed by spontaneous warming...
November 2014: European Journal of Applied Physiology
Jean-François Viallard, Catherine Ruiz, Marina Guillet, Jean-Luc Pellegrin, Jean-François Moreau
A higher chronic expansion of effector cytotoxic CD8(+)DR(+) T-lymphocytes has been reported in common variable immunodeficiency (CVID) patients with complications such as splenomegaly, autoimmune disease and/or granulomatous disease. In order to document the features associated with this T cell activation involving the CD8(+) T-compartment, we examined the diversity of the alpha/beta TCR repertoire of the patient's CD8(+) T-lymphocytes using the qualitative analysis of the CDR3 lengths (Immunoscope). Ten CIVD patients were enrolled in this study, four without complications (Group 1), six with complications (Group 2)...
2013: Results in Immunology
Mohamad Rida, Wafaa Karaki, Nesreen Ghaddar, Kamel Ghali, Jamal Hoballah
The purpose of this work was to integrate a new mathematical model with a bioheat model, based on physiology and first principles, to predict thermoregulatory arterio-venous anastomoses (AVA) and cold-induced vasodilation (CIVD) reaction to local cooling. The transient energy balance equations of body segments constrained by thermoregulatory controls were solved numerically to predict segmental core and skin temperatures, and arterial blood flow for given metabolic rate and environmental conditions. Two similar AVA-CIVD mechanisms were incorporated...
November 2014: International Journal of Biometeorology
Byeong Jo Kim, Yongsuk Seo, Jung-Hyun Kim, Dae Taek Lee
OBJECTIVE: The purpose of the study was to investigate the effect of caffeine intake on finger cold-induced vasodilation (CIVD). METHODS: Ten healthy men underwent 6 experimental trials characterized by control (NCAFF) or caffeine intake (CAFF) via chewing gum (300 mg of caffeine) while resting on a chair or performing submaximal (70% maximal oxygen consumption) or maximal (100% maximal oxygen consumption) treadmill exercise (Bruce protocol) followed by immersion of the middle finger in a water bath (5°C) for 20 minutes...
December 2013: Wilderness & Environmental Medicine
E S Smits, L S Duraku, S P Niehof, H A M Daanen, S E R Hovius, R W Selles, E T Walbeehm
PURPOSE: Cold-induced vasodilatation (CIVD) is a cyclic regulation of blood flow during prolonged cooling of protruding body parts. It is generally considered to be a protective mechanism against local cold injuries and cold intolerance after peripheral nerve injury. The aim of this study was to determine the role of the sympathetic system in initiating a CIVD response. METHODS: Eight rats were operated according to the spared nerve injury (SNI) model, eight underwent a complete sciatic lesion (CSL) and six underwent a sham operation...
September 2013: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Igor B Mekjavic, Uroš Dobnikar, Stylianos N Kounalakis
We evaluated the cold-induced vasodilatation (CIVD) response at 4 different water temperatures. Nine healthy young male subjects immersed their right hands in 35 °C water for 5 min, and immediately thereafter for 30 min in a bath maintained at either 5, 8, 10, or 15 °C. The responses of finger skin temperatures, subjective ratings of thermal comfort and temperature sensation scores were compared between the 4 immersion trials. The number of subjects who exhibited a CIVD response was higher during immersion of the hand in 5 and 8 °C (100%) compared with 10 and 15 °C water (87...
January 2013: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Mojca Amon, Michail E Keramidas, Stylianos N Kounalakis, Igor B Mekjavic
The present study evaluated the effect of a sleep high-train low regimen on the finger cold-induced vasodilation (CIVD) response. Seventeen healthy males were assigned to either a control (CON; n=9) or experimental (EXP; n=8) group. Each group participated in a 28-day aerobic training program of daily 1-h exercise (50% of peak power output). During the training period, the EXP group slept at a simulated altitude of 2800 meters (week 1) to 3400 m (week 4) above sea level. Normoxic (CIVD(NOR); CON and EXP groups) and hypoxic (CIVD(HYPO); F(I)O(2)=0...
March 2012: High Altitude Medicine & Biology
Wen Hu, Min Yang, Jingjian Chang, Zhongyi Shen, Tianwen Gu, Aidong Deng, Xiaosong Gu
Peripheral nerve repair requires comprehensive evaluation of functional outcomes of nerve regeneration; however, autonomic nerve function is seldom evaluated probably due to lack of suitable quantitative methods. This study sought to determine whether autonomic functional recovery could be reflected by cold-induced vasodilation (CIVD) within target skin territory, as monitored by laser Doppler perfusion imaging (LDPI). Rats with sciatic nerve defect injury received autologous nerve grafting, and the plantar surface of the hind feet was subjected to LDPI analysis following nerve repair...
February 2012: Microsurgery
Fabien Sauvet, C Bourrilhon, Y Besnard, A Alonso, J-M Cottet-Emard, G Savourey, J-C Launay
To study the effects of a 29-h total sleep deprivation (TSD) on local cold tolerance, 10 healthy men immersed their right hand for 30 min in a 5°C water bath (CWI) after a 30-min rest period in a thermoneutral environment (Control), after a normal night (NN) and after a 29-h TSD. CWI was followed by a 30-min passive rewarming (Recovery). Finger 2 and 4 skin temperatures (Tfi2, Tfi4) and finger 2 cutaneous vascular conductance (CVC) were monitored to study cold-induced vasodilation (CIVD). Rectal temperature (Tre), mean skin temperature ([Formula: see text]), heart rate (HR) and blood pressure (BP) were also measured...
September 2012: European Journal of Applied Physiology
Hein A M Daanen, Jens Koedam, Stephen S Cheung
Subjects that repeatedly have to expose the extremities to cold may benefit from a high peripheral temperature to maintain dexterity and tissue integrity. Therefore, we investigated if repeated immersions of a hand and a foot in cold water resulted in increased skin temperatures. Nine male and seven female subjects (mean 20.4; SD 2.2 years) immersed their right (trained) hand and foot simultaneously in 8°C water, 30 min daily for 15 days. During the pre and post-test (days 1 and 15, respectively) the left (untrained) hand and foot were immersed as well...
July 2012: European Journal of Applied Physiology
Stephen S Cheung, Hein A M Daanen
Humans residing or working in cold environments exhibit a stronger cold-induced vasodilation (CIVD) reaction in the peripheral microvasculature than those living in warm regions of the world, leading to a general assumption that thermal responses to local cold exposure can be systematically improved by natural acclimatization or specific acclimation. However, it remains unclear whether this improved tolerance is actually due to systematic acclimatization, or alternately due to the genetic pre-disposition or self-selection for such occupations...
January 2012: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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