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https://www.readbyqxmd.com/read/27905093/magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-for-treatment-of-drug-resistant-epilepsy
#1
Joon Y Kang, Michael R Sperling
Surgery is the most effective treatment for drug-resistant epilepsy. Long-term studies demonstrate that about 60% to 80% of patients become seizure-free after anterior temporal lobectomy and a majority of patients (about 95%) report significant seizure reduction after surgery. In the last few years, there has been significant advances in minimally invasive surgical techniques to treat drug-resistant epilepsy. These minimally invasive procedures have significant advantages over open surgery in that they produce less immediate discomfort and disability, while allowing for greater preservation of functional tissue...
November 30, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27896038/focal-seizures-induced-by-intracranial-electroencephalogram-grids
#2
Eric Hudgins, Mesha-Gay Brown, Brian Litt, Kathryn Davis, Andrew G Richardson, Timothy Lucas
Here we present a unique, but important seizure variant directly related to placement of subdural grids. Two distinct epileptogenic zones were identified, one which correlated with the patient's baseline seizures and a separate zone associated with atypical semiology and localization. Inspection of this zone at surgery revealed cortical deformation from the grid itself. The patient underwent successful surgical resection of the primary epileptogenic zone, but not that of the atypical zone. She remains seizure free at two years following surgery...
October 15, 2016: Curēus
https://www.readbyqxmd.com/read/27893578/propylthiouracil-associated-leukocytoclastic-necrotizing-cutaneous-vasculitis-a-case-report-and-review-of-the-literature
#3
Anji E Wall, Sheena M Weaver, Jeffrey S Litt, Lisa Rae
The purpose of this case report and review of the literature is to provide an exploration of the clinical symptoms, diagnosis, prevention, and management of propylthiouracil (PTU)-associated vasculitis in the intensive care setting. A PubMed search of the available literature was conducted using the MeSH search terms "propylthiouracil" and "vasculitis." The literature search returned 121 articles. Twenty-five were excluded because they were not in English. Fifty-nine case reports or case studies describing PTU-associated vasculitis were included...
November 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27883904/enabling-an-open-data-ecosystem-for-the-neurosciences
#4
Martin Wiener, Friedrich T Sommer, Zachary G Ives, Russell A Poldrack, Brian Litt
No abstract text is available yet for this article.
November 23, 2016: Neuron
https://www.readbyqxmd.com/read/27861328/laser-interstitial-thermal-therapy-for-mesial-temporal-lobe-epilepsy
#5
Robert T Wicks, Walter J Jermakowicz, Jonathan R Jagid, Daniel E Couture, Jon T Willie, Adrian W Laxton, Robert E Gross
: Approximately one-third of patients with epilepsy do not achieve adequate seizure control through medical management alone. Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of medically refractory epilepsy referred for surgical management. Stereotactic laser amygdalohippocampotomy using magnetic resonance-guided laser interstitial thermal therapy (MRg-LITT) is an important emerging therapy for MTLE. Initial published reports support MRg-LITT as a less invasive surgical option with a shorter hospital stay and fewer neurocognitive side effects compared with craniotomy for anterior temporal lobectomy with amygdalohippocampectomy and selective amygdalohippocampectomy...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861323/stereotactic-laser-interstitial-thermal-therapy-for-recurrent-high-grade-gliomas
#6
Ian Lee, Steven Kalkanis, Constantinos G Hadjipanayis
BACKGROUND: The value of maximal safe cytoreductive surgery in recurrent high-grade gliomas (HGGs) is gaining wider acceptance. However, patients may harbor recurrent tumors that may be difficult to access with open surgery. Laser interstitial thermal therapy (LITT) is emerging as a technique for treating a variety of brain pathologies, including primary and metastatic tumors, radiation necrosis, and epilepsy. OBJECTIVE: To review the role of LITT in the treatment of recurrent HGGs, for which current treatments have limited efficacy, and to discuss the possible role of LITT in the disruption of the blood-brain barrier to increase delivery of chemotherapy locoregionally...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861322/laser-ablation-of-newly-diagnosed-malignant-gliomas-a-meta-analysis
#7
Michael E Ivan, Alireza M Mohammadi, Nicoleta De Deugd, Joshua Reyes, Gregor Rodriguez, Ashish Shah, Gene H Barnett, Ricardo J Komotar
BACKGROUND: Magnetic resonance-guided laser-interstitial thermotherapy (MR-LITT) is a minimally invasive technique that shows promise in neuro-oncology because of its superiority in delivering precise minimally invasive thermal energy with minimal collateral damage. OBJECTIVE: In this analysis, we investigate initial data on the use of MR-LITT in the treatment of newly diagnosed high-grade gliomas. METHODS: With the use of the PubMed, OVID, and Google-scholar database systems, a comprehensive search of the English literature was performed...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861321/laser-interstitial-thermal-therapy-technology-physics-of-magnetic-resonance-imaging-thermometry-and-technical-considerations-for-proper-catheter-placement-during-magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy
#8
Nitesh V Patel, Matthew Mian, R Jason Stafford, Brian V Nahed, Jon T Willie, Robert E Gross, Shabbar F Danish
: Laser-induced thermal therapy has become a powerful tool in the neurosurgical armamentarium. The physics of laser therapy are complex, but a sound understanding of this topic is clinically relevant, as many centers have incorporated it into their treatment algorithm, and educated patients are demanding consideration of its use for their disease. Laser ablation has been used for a wide array of intracranial lesions. Laser catheter placement is guided by stereotactic planning; however, as the procedure has popularized, the number of ways in which the catheter can be inserted has also increased...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861320/laser-interstitial-thermal-therapy-lighting-the-way-to-a-new-treatment-option-in-neurosurgery
#9
Roberto Diaz, Michael E Ivan, Simon Hanft, Steve Vanni, Glen Manzano, Jonathan Jagid, Ricardo J Komotar
LITT, laser interstitial therapyNd:YAG, neodymium-doped yttrium aluminum.
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861319/introduction-for-laser-interstitial-thermal-therapy-litt-in-neurosurgery-supplement
#10
Simon Buttrick, Ricardo J Komotar
LITT, laser interstitial thermal therapy.
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27810004/enabling-an-open-data-ecosystem-for-the-neurosciences
#11
Martin Wiener, Friedrich T Sommer, Zachary G Ives, Russell A Poldrack, Brian Litt
As the pace and complexity of neuroscience data grow, an open data ecosystem must develop and grow with it to allow neuroscientists the ability to reach for new heights of discovery. However, the problems and complexities of neuroscience data sharing must first be addressed. Among the challenges facing data sharing in neuroscience, the problem of incentives, discoverability, and sustainability may be the most pressing. We here describe these problems and provide potential future solutions to help cultivate an ecosystem for data sharing...
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27807850/temporal-behavior-of-seizures-and-interictal-bursts-in-prolonged-intracranial-recordings-from-epileptic-canines
#12
Hoameng Ung, Kathryn A Davis, Drausin Wulsin, Joost Wagenaar, Emily Fox, John J McDonnell, Ned Patterson, Charles H Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic intracranial recordings in canine epilepsy. METHODS: Continuous, yearlong intracranial electroencephalography (iEEG) recordings from four dogs with naturally occurring epilepsy were analyzed for seizures and interictal bursts...
November 3, 2016: Epilepsia
https://www.readbyqxmd.com/read/27765720/magnetic-resonance-guided-laser-ablation-for-the-treatment-of-recurrent-dural-based-lesions-a-series-of-five-cases
#13
Michael E Ivan, Roberto Jose Diaz, Michael H Berger, Gregory W Basil, David A Osiason, Thomas Plate, Amanda Wallo, Ricardo J Komotar
BACKGROUND AND OBJECTIVE: Magnetic resonance-guided laser-induced thermotherapy (MR-LITT) is a minimally invasive technique that shows promise in neuro-oncology due to its superiority in delivering precise minimally invasive thermal energy with minimal collateral damage. In this analysis we investigate initial data on MR-LITT's effect on dural based lesions. METHODS: Five patients were identified with dural based lesions (4 meningiomas, 1 solitary fibrous tumor) with clear evidence of radiological progression...
October 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27755466/survey-of-household-contacts-of-infants-with-laboratory-confirmed-pertussis-infection-during-a-national-pertussis-outbreak-in-england-and-wales
#14
Edna O Kara, Helen Campbell, Sonia Ribeiro, Norman K Fry, David Litt, Seyi Eletu, Gayatri Amirthalingam
BACKGROUND: Highest rates of pertussis occur in infants <3 months old, too young to be fully vaccinated. The 2012 national outbreak provided a valuable opportunity to study sources of infection for these infants at highest risk of severe complications and death. METHODS: Households of infants <3 months old with laboratory-confirmed pertussis between 08/2012 and 10/2013 were invited to complete a questionnaire with information on household members' demographics, relationship with the infant, chronology of cough onset where relevant, and vaccination history...
October 17, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27690660/stereotactic-robot-assisted-mri-guided-laser-thermal-ablation-of-radiation-necrosis-in-the-posterior-cranial-fossa-technical-note
#15
Alvin Y Chan, Diem Kieu T Tran, Amandip S Gill, Frank P K Hsu, Sumeet Vadera
Laser interstitial thermal therapy (LITT) is a minimally invasive procedure used to treat a variety of intracranial lesions. Utilization of robotic assistance with stereotactic procedures has gained attention due to potential for advantages over conventional techniques. The authors report the first case in which robot-assisted MRI-guided LITT was used to treat radiation necrosis in the posterior fossa, specifically within the cerebellar peduncle. The use of a stereotactic robot allowed the surgeon to perform LITT using a trajectory that would be extremely difficult with conventional arc-based techniques...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27690659/intracerebral-laser-interstitial-thermal-therapy-followed-by-tumor-resection-to-minimize-cerebral-edema
#16
Sindhura Pisipati, Kyle A Smith, Kushal Shah, Koji Ebersole, Roukoz B Chamoun, Paul J Camarata
OBJECTIVE Laser interstitial thermal therapy (LITT) is used in numerous neurosurgical applications including lesions that are difficult to resect. Its rising popularity can be attributed to its minimally invasive approach, improved accuracy with real-time MRI guidance and thermography, and enhanced control of the laser. One of its drawbacks is the possible development of significant edema, which contributes to extended hospital stays and often necessitates hyperosmolar or steroid therapy. Here, the authors discuss the use of minimally invasive craniotomy to resect tissue ablated with LITT in attempt to minimize cerebral edema...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27690658/laser-interstitial-thermal-therapy-followed-by-minimal-access-transsulcal-resection-for-the-treatment-of-large-and-difficult-to-access-brain-tumors
#17
James Wright, Jessey Chugh, Christina Huang Wright, Fernando Alonso, Alia Hdeib, Haley Gittleman, Jill Barnholtz-Sloan, Andrew E Sloan
OBJECTIVE Laser interstitial thermal therapy (LITT), sometimes referred to as "stereotactic laser ablation," has demonstrated utility in a subset of high-risk surgical patients with difficult to access (DTA) intracranial neoplasms. However, the treatment of tumors larger than 10 cm(3) is associated with suboptimal outcomes and morbidity. This may limit the utility of LITT in dealing with precisely those large or deep tumors that are most difficult to treat with conventional approaches. Recently, several groups have reported on minimally invasive transsulcal approaches utilizing tubular retracting systems...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27690657/laser-interstitial-thermal-therapy-for-newly-diagnosed-and-recurrent-glioblastoma
#18
Jonathan G Thomas, Ganesh Rao, Yvonne Kew, Sujit S Prabhu
OBJECTIVE Glioblastoma (GBM) is the most common and deadly malignant primary brain tumor. Better surgical therapies are needed for newly diagnosed GBMs that are difficult to resect and for GBMs that recur despite standard therapies. The authors reviewed their institutional experience of using laser interstitial thermal therapy (LITT) for the treatment of newly diagnosed or recurrent GBMs. METHODS This study reports on the pre-LITT characteristics and post-LITT outcomes of 8 patients with newly diagnosed GBMs and 13 patients with recurrent GBM who underwent LITT...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27690653/thermal-injury-to-corticospinal-tracts-and-postoperative-motor-deficits-after-laser-interstitial-thermal-therapy
#19
Mayur Sharma, Ghaith Habboub, Mandana Behbahani, Danilo Silva, Gene H Barnett, Alireza M Mohammadi
OBJECTIVE Laser interstitial thermal therapy (LITT) has been increasingly used to treat deep-seated tumors. Despite its being minimally invasive, there is a risk of LITT damaging adjacent critical structures, including corticospinal tracts (CSTs). In this study, the authors investigated the predictive value of overlap between the hyperthermic field and CSTs in determining postoperative motor deficit (PMDs). METHODS More than 140 patients underwent an LITT procedure in our institution between April 2011 and June 2015...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27690652/utilizing-personalized-stereotactic-frames-for-laser-interstitial-thermal-ablation-of-posterior-fossa-and-mesiotemporal-brain-lesions-a-single-institution-series
#20
David Y A Dadey, Ashwin A Kamath, Matthew D Smyth, Michael R Chicoine, Eric C Leuthardt, Albert H Kim
OBJECTIVE The precision of laser probe insertion for interstitial thermal therapy of deep-seated lesions is limited by the method of stereotactic guidance. The objective of this study was to evaluate the feasibility of customized STarFix 3D-printed stereotactic platforms to guide laser probe insertion into mesiotemporal and posterior fossa targets. METHODS The authors conducted a retrospective review of 5 patients (12-55 years of age) treated with laser interstitial thermal therapy (LITT) in which STarFix platforms were used for probe insertion...
October 2016: Neurosurgical Focus
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