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https://www.readbyqxmd.com/read/28643045/validation-of-a-mathematical-model-for-laser-induced-thermotherapy-in-liver-tissue
#1
F Hübner, C Leithäuser, B Bazrafshan, N Siedow, T J Vogl
The purpose of the study was to develop a simulation approach for laser-induced thermotherapy (LITT) that is based on mathematical models for radiation transport, heat transport, and tissue damage. The LITT ablation was applied to ex vivo pig liver tissue. Experiments were repeated with different laser powers, i.e., 22-34 W, and flow rates of the cooling water in the applicator system, i.e., 47-92 ml/min. During the procedure, the temperature was measured in the liver sample at different distances to the applicator as well as in the cooling circuit using a fiber optic thermometer...
June 22, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28622515/a-mechanogenetic-toolkit-for-interrogating-cell-signaling-in-space-and-time
#2
Daeha Seo, Kaden M Southard, Ji-Wook Kim, Hyun Jung Lee, Justin Farlow, Jung-Uk Lee, David B Litt, Thomas Haas, A Paul Alivisatos, Jinwoo Cheon, Zev J Gartner, Young-Wook Jun
No abstract text is available yet for this article.
June 15, 2017: Cell
https://www.readbyqxmd.com/read/28604542/outcome-of-dupuytren-contractures-after-collagenase-clostridium-histolyticum-injection-a-single-institution-experience
#3
Yin Kan Hwee, Daniel Park, Marisa Vinas, Christopher Litts, David Friedman
BACKGROUND: Collagenase clostridium histolyticum (CCH) injection is an alternative to surgery for patients with Dupuytren disease (DD) of the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. The success of surgical and nonsurgical treatment modalities for DD is reported to vary widely between 25% and 80% (J Bone Joint Surg Am. 1985;67:1439-1443; Plast Reconstr Surg. 2007;120:44e-54e; J Bone Joint Surg Am. 2007;89:189-198; J Hand Surg Am. 2011:36:936-942; J Hand Surg Am...
June 9, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28598516/intratumor-cisplatin-nephrotoxicity-in-combined-laser-induced-thermal-therapy-for-cancer-treatment
#4
Marcel N Palumbo, Onivaldo Cervantes, Cecilia Eugênio, Flávia T P Hortense, João C Ribeiro, Ana Amélia P Paolini, Antônio C Tedesco, Joel A Sercarz, Marcos B Paiva
INTRODUCTION: Thermal ablation of tumors by Nd:YAG laser has been growing as a multidisciplinary subspecialty defined as laser-induced thermal therapy (LITT), and has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent cancer. Previous studies have shown that adjuvant chemotherapy can potentiate laser thermal ablation of tumors leading to improved palliation in advanced cancer patients. OBJECTIVE: Evaluate nephrotoxicity by early markers of renal function in treating head and neck cancer using intra-tumor injections of cisplatin combined with laser-induced thermal therapy (CDDP-LITT)...
June 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28591480/laser-interstitial-thermal-therapy-a-first-line-treatment-for-seizures-due-to-hypothalamic-hamartoma
#5
Victor X Du, Shashank V Gandhi, Harold L Rekate, Ashesh D Mehta
Successful treatment of hypothalamic hamartoma (HH) can result in the resolution of its sequelae including epilepsy and rage attacks. Risks and morbidity of open surgical management of this lesion have motivated the development of laser interstitial thermal therapy (LITT) as a less invasive treatment approach to the disease. Although overall morbidity and risk would appear to be lower, complications related to LITT therapy have been reported, and the longer-term follow-up that is now possible after initial experience helps address the question of whether LITT provides equivalent efficacy compared to other treatment options...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28580377/optimization-of-curvilinear-needle-trajectories-for-transforamenal-hippocampotomy
#6
David B Comber, E Bryn Pitt, Hunter B Gilbert, Matthew W Powelson, Emily Matijevich, Joseph S Neimat, Robert J Webster, Eric J Barth
BACKGROUND: The recent development of MRI-guided laser-induced thermal therapy (LITT) offers a minimally invasive alternative to craniotomies performed for tumor resection or for amygdalohippocampectomy to control seizure disorders. Current LITT therapies rely on linear stereotactic trajectories that mandate twist-drill entry into the skull and potentially long approaches traversing healthy brain. The use of robotically-driven, telescoping, curved needles has the potential to reduce procedure invasiveness by tailoring trajectories to the curved shape of the ablated structure and by enabling access through natural orifices...
February 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28540791/ablation-therapy-of-non-colorectal-cancer-lung-metastases-retrospective-analysis-of-tumour-response-post-laser-induced-interstitial-thermotherapy-litt-radiofrequency-ablation-rfa-and-microwave-ablation-mwa
#7
Nour-Eldin A Nour-Eldin, Sybille Exner, Mohammed Al-Subhi, Nagy N N Naguib, Benjamin Kaltenbach, Andrei Roman, Thomas J Vogl
PURPOSE: To retrospectively compare the local tumour response and survival rates in patients with non-colorectal cancer lung metastases post-ablation therapy using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA) and microwave ablation (MWA). MATERIAL AND METHODS: Retrospective analysis of 175 computed tomography (CT)-guided ablation sessions performed on 109 patients (43 males and 66 females, mean age: 56.6 years). Seventeen patients with 22 lesions underwent LITT treatment (tumour size: 1...
April 3, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28502693/prolonged-blood-brain-barrier-disruption-following-laser-interstitial-ablation-in-epilepsy-a-case-series-with-a-case-report-of-post-ablation-optic-neuritis
#8
Saint-Aaron Morris, Matthew Rollo, Patrick Rollo, Jessica Johnson, Gerald A Grant, Elliott Friedman, Giridhar Kalamangalam, Nitin Tandon
OBJECTIVE: Laser interstitial thermal therapy (LITT) has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in more than a thousand patients, the chronic effects of photo-thermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed the clinical and radiographic courses of a cohort undergoing laser ablation for focal epilepsy. Only patients with non-enhancing lesions and those who had a delayed post-operative MRI with gadolinium administration approximately 6 months after the ablation were considered...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28502023/sources-of-care-for-alcohol-and-other-drug-problems-the-role-of-the-african-american-church
#9
Eunice C Wong, Kathryn P Derose, Paula Litt, Jeremy N V Miles
African Americans experience significant disparities in treatment access, retention, and quality of care for alcohol and drug use (AOD) problems. Religious congregations, often the first point of contact for help with AOD problems, can play an integral role in improving access to treatment. However, little is known about the role of African American churches in addressing AOD problems. We administered a survey to a faith-based collaborative of 169 African American churches in Los Angeles to examine how AOD problems are identified in congregations, the types of support provided, barriers to providing treatment referrals, and factors associated with the provision of treatment referrals...
May 13, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28495211/maximum-aortic-valve-opening-phase-for-annulus-sizing-in-pre-tavr-cta
#10
Nam Ju Lee, Saurabh Jha, Bong Ju Lee, Harold Litt
RATIONALE AND OBJECTIVES: The optimal phase for the measurement of the aortic annular area for transcatheter aortic valve replacement (TAVR) is not standardized, although most agree that systolic measurements are preferred, when the annulus is larger. We hypothesized that the maximum annular area occurs at the cardiac phase of the maximum aortic valve opening (MAVO) and that this phase can be accurately and reproducibly assessed by visual inspection only. MATERIALS AND METHODS: The aortic valve opening area was inspected visually by two readers to determine the MAVO phase...
May 8, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28487318/impact-of-coronary-calcification-on-clinical-management-in-patients-with-acute-chest-pain
#11
RANDOMIZED CONTROLLED TRIAL
Daniel O Bittner, Thomas Mayrhofer, Fabian Bamberg, Travis R Hallett, Sumbal Janjua, Daniel Addison, John T Nagurney, James E Udelson, Michael T Lu, Quynh A Truong, Pamela K Woodard, Judd E Hollander, Chadwick Miller, Anna Marie Chang, Harjit Singh, Harold Litt, Udo Hoffmann, Maros Ferencik
BACKGROUND: Coronary artery calcification (CAC) may impair diagnostic assessment of coronary computed tomography angiography (CTA). We determined whether CAC affects efficiency of coronary CTA in patients with suspected acute coronary syndrome (ACS). METHODS AND RESULTS: This is a pooled analysis of ACRIN-PA (American College of Radiology Imaging Network-Pennsylvania) 4005 and the ROMICAT-II trial (Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography) comparing an initial coronary CTA strategy to standard of care in acute chest pain patients...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28487137/clinical-risk-factors-alone-are-inadequate-for-predicting-significant-coronary-artery-disease
#12
Frederick K Korley, Constantine Gatsonis, Bradley S Snyder, Richard T George, Thura Abd, Stefan L Zimmerman, Harold I Litt, Judd E Hollander
OBJECTIVE: We sought to derive and validate a model for identifying suspected ACS patients harboring undiagnosed significant coronary artery disease (CAD). METHODS: This was a secondary analysis of data from a randomized control trial (RCT). Patients randomized to the CTA arm of an RCT examining a CTA-based strategy for ruling-out acute coronary syndrome (ACS) constitute the derivation cohort, which was randomly divided into a training dataset (2/3, used for model derivation) and a test dataset (1/3, used for internal validation (IV))...
July 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28485976/use-of-nanoparticle-contrast-agents-for-cell-tracking-with-computed-tomography
#13
Johoon Kim, Peter Chhour, Jessica Hsu, Harold I Litt, Victor A Ferrari, Rachela Popovtzer, David P Cormode
Efforts to develop novel cell-based therapies originated with the first bone marrow transplant on a leukemia patient in 1956. Preclinical and clinical examples of cell-based treatment strategies have shown promising results across many disciplines in medicine, with recent advances in immune cell therapies for cancer producing remarkable response rates, even in patients with multiple treatment failures. However, cell-based therapies suffer from inconsistent outcomes, motivating the search for tools that allow monitoring of cell delivery and behavior in vivo...
June 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28459961/crowdsourcing-seizure-detection-algorithm-development-and-validation-on-human-implanted-device-recordings
#14
Steven N Baldassano, Benjamin H Brinkmann, Hoameng Ung, Tyler Blevins, Erin C Conrad, Kent Leyde, Mark J Cook, Ankit N Khambhati, Joost B Wagenaar, Gregory A Worrell, Brian Litt
There exist significant clinical and basic research needs for accurate, automated seizure detection algorithms. These algorithms have translational potential in responsive neurostimulation devices and in automatic parsing of continuous intracranial electroencephalography data. An important barrier to developing accurate, validated algorithms for seizure detection is limited access to high-quality, expertly annotated seizure data from prolonged recordings. To overcome this, we hosted a kaggle.com competition to crowdsource the development of seizure detection algorithms using intracranial electroencephalography from canines and humans with epilepsy...
June 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28456420/the-evolution-of-outer-retinal-tubulation-a-neurodegeneration-and-gliosis-prominent-in-macular-diseases
#15
Rosa Dolz-Marco, Katie M Litts, Anna C S Tan, K Bailey Freund, Christine A Curcio
PURPOSE: To document outer retinal tubulation (ORT) formation in advanced retinal disorders. DESIGN: Retrospective, observational study. PARTICIPANTS: Consecutive cases with retinal diseases showing outer retinal disruption and atrophy of the retinal pigment epithelium (RPE) associated with ORT on spectral-domain (SD) optical coherence tomography (OCT) at the final available visit. METHODS: Cross-sectional SD OCT scans showing ORT at the last available visit were compared with eye-tracked baseline scans...
April 26, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28417602/novel-use-of-perfusion-balloon-inflation-to-avoid-outflow-tract-obstruction-during-transcatheter-mitral-valve-in-valve-replacement
#16
Howard C Herrmann, Wilson Y Szeto, Harold Litt, William Vernick
Left ventricular outflow tract (LVOT) obstruction is a recognized complication of transcatheter mitral valve-in-valve replacement in previous surgical prostheses. We describe a patient who was high risk for repeat open surgery in whom the LVOT was compromised by a surgical strut and the potential for LVOT obstruction. A novel approach to avoiding this complication was utilized. A perfusion balloon was inflated in the outflow tract to provide an opposing force during mitral valve deployment resulting in less flaring of the strut into the outflow tract thereby improving the neo-LVOT area...
April 18, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28411414/laser-interstitial-thermotherapy-litt-in-epilepsy-surgery
#17
REVIEW
Christian Hoppe, Juri-Alexander Witt, Christoph Helmstaedter, Thomas Gasser, Hartmut Vatter, Christian E Elger
Besides other innovative stereotactic procedures (radiofrequency thermocoagulation, focused ultrasound, gamma knife) laser interstitial thermotherapy (LiTT) provides minimally invasive destruction of pathological soft tissues which could be especially relevant for epilepsy surgeries involving adult and pediatric patients. Unlike standard resections, no craniotomy is required; just a tiny borehole trepanation is sufficient. Damage to cortical areas when accessing deep lesions can be minimized or completely avoided, and treating epileptogenic foci near eloquent or even vital brain areas becomes possible...
April 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28409062/improved-availability-and-quality-of-care-with-epilepsy-nurse-practitioners
#18
Chloe E Hill, Bethany Thomas, Kimberly Sansalone, Kathryn A Davis, Judy A Shea, Brian Litt, Nabila Dahodwala
BACKGROUND: This study investigated the quality of care delivered by nurse practitioner (NP)-physician teams employed to expand clinic appointment availability for patients with epilepsy. METHODS: We performed a retrospective observational cohort study of patients with epilepsy presenting to the Penn Epilepsy Center for a new patient appointment in 2014. During this time, patients were seen either by an NP-physician team care model or a more traditional physician-only care model...
April 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28395232/laser-interstitial-thermotherapy-application-for-breast-surgery-current-situation-and-new-trends
#19
REVIEW
Yohan Kerbage, Nacim Betrouni, Pierre Collinet, Henri Azaïs, Serge Mordon, Anne-Sophie Dewalle-Vignion, Benjamin Merlot
While breast specialists debate on therapeutic de-escalation in breast cancer, the treatment of benign lesions is also discussed in relation to new percutaneous ablation techniques. The purpose of these innovations is to minimize potential morbidity. Laser Interstitial ThermoTherapy (LITT) is an option for the ablation of targeted nodules. This review evaluated the scientific publications investigating the LITT approach in malignant and benign breast disease. Three preclinical studies and eight clinical studies (2 studies including fibroadenomas and 6 studies including breast cancers) were reviewed...
June 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28362211/laser-interstitial-thermal-therapy-for-palliative-ablation-of-a-chordoma-metastasis-to-the-spine-case-report
#20
Brian J Williams, Patrick J Karas, Ganesh Rao, Laurence D Rhines, Claudio E Tatsui
The authors present the first report of laser interstitial thermal therapy (LITT) ablation of a recurrent chordoma metastasis to the cervical spine. This patient was a 75-year-old woman who was diagnosed and treated for a sacral chordoma, and then developed metastases to the lung and upper thoracic spine. Unfortunately she experienced symptomatic recurrence at the C-7 spinous process. She underwent an uncomplicated LITT to the lesion. The patient convalesced without incident and was discharged on postoperative Day 1...
March 31, 2017: Journal of Neurosurgery. Spine
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