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https://www.readbyqxmd.com/read/29773594/interleukin-22-levels-are-increased-in-gastrointestinal-graft-versus-host-disease-in-children
#1
Dana T Lounder, Pooja Khandelwal, Nicholas J Gloude, Christopher E Dandoy, Sonata Jodele, Mario Medvedovic, Lee A Denson, Adam Lane, Kelly Lake, Bridget Litts, Alyss Wilkey, Stella M Davies
No abstract text is available yet for this article.
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29772367/patterns-of-clinical-utilization-of-stereotactic-laser-ablation-sla-an-analysis-of-the-multi-center-prospective-registry
#2
Robert C Rennert, Usman Khan, Stephen B Tatter, Melvin Field, Brian Toyota, Peter E Fecci, Kevin Judy, Alireza M Mohammadi, Patrick Landazuri, Andrew Sloan, Eric Leuthardt, Clark C Chen
BACKGROUND: Stereotactic laser ablation (SLA), also termed laser interstitial thermal therapy (LITT), is a minimally invasive procedure that is increasingly utilized in neurosurgery. We wished to examine how/if SLA is changing the landscape of treatment options for neurosurgical patients. METHODS: Patients undergoing stereotactic laser ablation were prospectively enrolled in the Laser Ablation of Abnormal Neurological Tissue (LAANTERN) registry. Data from the first 100 enrolled patients are presented here...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29726782/laser-ablation-after-stereotactic-radiosurgery-a-multicenter-prospective-study-in-patients-with-metastatic-brain-tumors-and-radiation-necrosis
#3
Manmeet Ahluwalia, Gene H Barnett, Di Deng, Stephen B Tatter, Adrian W Laxton, Alireza M Mohammadi, Eric Leuthardt, Roukoz Chamoun, Kevin Judy, Anthony Asher, Marco Essig, Jorg Dietrich, Veronica L Chiang
OBJECTIVE Laser Ablation After Stereotactic Radiosurgery (LAASR) is a multicenter prospective study of laser interstitial thermal (LITT) ablation in patients with radiographic progression after stereotactic radiosurgery for brain metastases. METHODS Patients with a Karnofsky Performance Scale (KPS) score ≥ 60, an age > 18 years, and surgical eligibility were included in this study. The primary outcome was local progression-free survival (PFS) assessed using the Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29714337/temperature-dependent-litt-effect-in-c-axis-inclined-bicuseo-thin-films
#4
Lingyun Wang, Guoying Yan, Shuaihang Hou, Shuang Guo, Jianglong Wang, Nian Fu, Shufang Wang
Light-induced transverse thermoelectric (LITT) effect in c axis inclined BiCuSeO thin films was investigated in the temperature range of 80-300 K by using three different lasers with the wavelength changing from visible to mid-IR. Obvious open-circuit voltage signals were all detected when the film surface was illuminated by these lasers, and the amplitude Vp of the induced voltage signals was found to increase with the measured temperature. The improvement of Vp at a higher temperature can be explained by the enhanced anisotropy of the Seebeck coefficient as well as the reduced thermal conductivity of the film...
April 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29625839/choroidal-and-sub-retinal-pigment-epithelium-caverns-multimodal-imaging-and-correspondence-with-friedman-lipid-globules
#5
Rosa Dolz-Marco, Jay P Glover, Orly Gal-Or, Katie M Litts, Jeffrey D Messinger, Yuhua Zhang, Mariano Cozzi, Marco Pellegrini, K Bailey Freund, Giovanni Staurenghi, Christine A Curcio
PURPOSE: To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. DESIGN: Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis. PARTICIPANTS: Donor eyes (n = 139; 26 with early AMD, 13 with GA, 40 with nAMD, 52 with a healthy macula, and 8 with other or unknown characteristics) and 41 eyes of 28 participants with GA (n = 16), nAMD (n = 8), Stargardt disease (n = 4), cone dystrophy (n = 2), pachychoroid spectrum (n = 6), choroidal hemangioma (n = 1), and healthy eyes (n = 4)...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29625550/classification-and-phylogenetic-analyses-of-the-arabidopsis-and-tomato-g-type-lectin-receptor-kinases
#6
Marcella A Teixeira, Alex Rajewski, Jiangman He, Olenka G Castaneda, Amy Litt, Isgouhi Kaloshian
BACKGROUND: Pathogen perception by plants is mediated by plasma membrane-localized immune receptors that have varied extracellular domains. Lectin receptor kinases (LecRKs) are among these receptors and are subdivided into 3 classes, C-type LecRKs (C-LecRKs), L-type LecRKs (L-LecRKs) and G-type LecRKs (G-LecRKs). While C-LecRKs are represented by one or two members in all plant species investigated and have unknown functions, L-LecRKs have been characterized in a few plant species and have been shown to play roles in plant defense against pathogens...
April 6, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29624104/characterization-of-bacteriophages-targeting-non-o157-shiga-toxigenic-escherichia-coli
#7
Pushpinder Kaur Litt, Joyjit Saha, Divya Jaroni
Non-O157 Shiga toxigenic Escherichia coli (STEC) are an important group of foodborne pathogens, implicated in several outbreaks and recalls in the past 2 decades. It is therefore crucial to devise effective control strategies against these pathogens. Bacteriophages present an attractive alternative to conventional pathogen control methods in the food industry. Bacteriophages, targeting non-O157 STEC (O26, O45, O103, O111, O121, O145), were isolated from beef cattle operations in Oklahoma. Their host range and lytic ability were determined against several ( n = 21) non-O157 STEC isolates, by using the spot-on-lawn assay...
April 6, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29606224/individual-versus-group-female-specific-cognitive-behavior-therapy-for-alcohol-use-disorder
#8
Elizabeth E Epstein, Barbara S McCrady, Kevin A Hallgren, Ayorkor Gaba, Sharon Cook, Noelle Jensen, Thomas Hildebrandt, Cathryn Glanton Holzhauer, Mark D Litt
OBJECTIVES: To test group-based Female-Specific Cognitive Behavioral Therapy (G-FS-CBT) for women with Alcohol Use Disorder (AUD) against an individual Female-Specific Cognitive Behavioral Therapy (I-FS-CBT). This aims of this paper are to describe G-FS-CBT development, content, feasibility, acceptability, group process, engagement in treatment, and within- and post-treatment outcomes. METHODS: Women with AUD (n=155) were randomly assigned to 12 manual-guided sessions of G-FS-CBT or I-FS-CBT; 138 women attended at least one treatment session...
May 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29605700/stereoelectroencephalography-guided-radiofrequency-thermocoagulation-for-hypothalamic-hamartomas-preliminary-evidence
#9
Peng-Hu Wei, Yang An, Xiao-Tong Fan, Yi-He Wang, Yan-Feng Yang, Lian-Kun Ren, Yong-Zhi Shan, Guo-Guang Zhao
BACKGROUND: The use of magnetic resonance imaging (MRI)-guided ablation methods, such as laser interstitial thermal therapy and MRI-guided radiofrequency thermocoagulation (RF-TC), poses a risk of mistreatment in patients with nonepileptic hypothalamic hamartoma (HH). Using stereoelectroencephalography (SEEG)-guided RF-TC could solve this problem; however, there are no reports on the efficacy of this technique. Thus, we examined the safety and efficacy of this method. METHODS: This retrospective study was conducted in 9 consecutive patients with HH treated between August 2015 and July 2017...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29575339/treatment-response-and-non-response-in-cbt-and-network-support-for-alcohol-disorders-targeted-mechanisms-and-common-factors
#10
Mark D Litt, Ronald M Kadden, Howard Tennen
AIMS: To determine whether mechanisms of drinking behavior-change that are targeted by specific treatments mediate the effects of Packaged Cognitive-Behavior Therapy (PCBT) and Network Support (NS) on abstinence rates over 27 months. DESIGN: Secondary analysis of data from two Network Support Project randomized clinical trials (1, 2), in which participants were assigned to either a case management control treatment (Control) or NS treatment in trial 1, or to PCBT or NS Treatment in trial 2...
March 25, 2018: Addiction
https://www.readbyqxmd.com/read/29570388/contemporaneous-biopsy-and-laser-interstitial-thermal-therapy-for-two-treatment-refractory-brain-metastases
#11
Ashish H Shah, Angela M Richardson, Joshua D Burks, Ricardo J Komotar
Recurrent treatment-refractory brain metastases can be treated with modern adjuvant therapies such as laser interstitial thermal therapy (LITT). Since previously radiated lesions may be indolent (treatment effect) or recurrent tumor, histological confirmation may be helpful. The authors present the utility of contemporaneous biopsy and LITT using intraoperative O-arm navigation in a patient who presented with multiple refractory metastases. The authors demonstrate the utility of O-arm navigation to confirm intraoperative biopsy and LITT placement...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29570387/introduction-to-laser-ablation-video-supplement
#12
Gene H Barnett, Andrew E Sloan, Claudio E Tatsui
Laser ablation (also known as laser interstitial thermal therapy [LITT]) has emerged as an important new technology for treating various disorders of the brain and spine. As with any new or emerging technology, there is a learning curve for its optimal use, and video tutorials can be important learning tools to help bridge gaps in knowledge for those who wish to become more familiar with laser ablation. In this special supplement to Neurosurgical Focus, videos illustrate laser ablation's use in the treatment of epilepsy and failed radiosurgery, as well as technical aspects of performing these procedures in eloquent brain and in the spine...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29570386/laser-interstitial-thermal-therapy-for-an-eloquent-region-supratentorial-brain-lesion
#13
Mayur Sharma, Daria Krivosheya, Hamid Borghei-Razavi, Gene H Barnett, Alireza M Mohammadi
Laser interstitial thermal therapy (LITT) is a minimally invasive stereotactic technique that causes tumor ablation using thermal energy. LITT has shown to be efficacious for the treatment of deep-seated brain lesions, including those near eloquent areas. In this video, the authors present the case of a 62-year-old man with a history of metastatic melanoma who presented with worsening right-sided hemiparesis. MRI revealed a contrast-enhancing lesion in left centrum semiovale in close proximity to corticospinal tracts, consistent with radiation necrosis...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29563043/rationale-and-design-for-the-community-activation-for-prevention-study-caps-a-randomized-controlled-trial-of-community-gardening
#14
J S Litt, K Alaimo, M Buchenau, A Villalobos, D H Glueck, T Crume, L Fahnestock, R F Hamman, J R Hebert, T G Hurley, J Leiferman, K Li
BACKGROUND: Engaging in health-promoting behaviors (e.g., healthy fruit- and vegetable-rich diet, physical activity) and living in supportive social and built environments are consistently and significantly associated with reductions in cancer, heart disease, diabetes, and other chronic diseases. Interventions to change diet and physical activity behaviors should aim to educate individuals, change the environments in which people live, work and recreate, improve access, availability, and affordability of healthy foods, and create safe places the facilitate active lifestyles...
May 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29562253/describing-perceived-racial-bias-among-youth-with-sickle-cell-disease
#15
Emily O Wakefield, Ashley Pantaleao, Jill M Popp, Lourdes P Dale, James P Santanelli, Mark D Litt, William T Zempsky
Objectives: Sickle cell disease (SCD) predominately affects Black Americans. This is the first study of its kind to describe the racial bias experiences of youth with SCD and their reactions to these experiences. Methods: Participants were 20 youth with SCD (ages 13-21 years) who were asked to describe any racial bias events they experienced, as recorded on the Perception of Racism in Children and Youth measure (PRaCY). Interviews were recorded, transcribed, and analyzed by two independent raters using a conventional content analysis approach...
March 17, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29536345/the-safety-of-magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-for-cerebral-radiation-necrosis
#16
Richard Rammo, Karam Asmaro, Lonni Schultz, Lisa Scarpace, Salim Siddiqui, Tobias Walbert, Steven Kalkanis, Ian Lee
Cerebral radiation necrosis (CRN) is a known complication of radiation therapy. Treatment options are limited and include steroids, bevacizumab, and surgery. This study seeks to determine the safety of laser interstitial thermal therapy (LITT) for CRN and identify the pattern of post-ablation volume change over time. Patients undergoing LITT for tumor treatment at Henry Ford Hospital between November 2013 and January 2016 with biopsy-confirmed CRN were prospectively collected and retrospectively reviewed with attention to ablation volume, survival, demographic data, steroid dose, and complications...
March 13, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29528488/automated-trajectory-planning-for-laser-interstitial-thermal-therapy-in-mesial-temporal-lobe-epilepsy
#17
Vejay N Vakharia, Rachel Sparks, Kuo Li, Aidan G O'Keeffe, Anna Miserocchi, Andrew W McEvoy, Michael R Sperling, Ashwini Sharan, Sebastien Ourselin, John S Duncan, Chengyuan Wu
OBJECTIVE: Surgical resection of the mesial temporal structures brings seizure remission in 65% of individuals with drug-resistant mesial temporal lobe epilepsy (MTLE). Laser interstitial thermal therapy (LiTT) is a novel therapy that may provide a minimally invasive means of ablating the mesial temporal structures with similar outcomes, while minimizing damage to the neocortex. Systematic trajectory planning helps ensure safety and optimal seizure freedom through adequate ablation of the amygdalohippocampal complex (AHC)...
April 2018: Epilepsia
https://www.readbyqxmd.com/read/29520449/cardiac-ct-in-the-emergency-department-contrasting-evidence-from-registries-and-randomized-controlled-trials
#18
REVIEW
Nam Ju Lee, Harold Litt
PURPOSE OF REVIEW: To compare outcomes between registries and randomized controlled trials of coronary computed tomographic angiography (CCTA)-based versus standard of care approaches to the initial evaluation of patients with acute chest pain. RECENT FINDINGS: Randomized trials have demonstrated CCTA to be a safe and efficient tool for triage of low- to intermediate-risk patients presenting to the emergency department with chest pain. Recent studies demonstrate heterogeneous result using different standard of care approaches for evaluation of hard endpoints in comparison with standard evaluation...
March 8, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29488838/spatiotemporal-evolution-of-focal-epileptiform-activity-from-surface-and-laminar-field-recordings-in-cat-neocortex
#19
Hank Bink, Madineh Sedigh-Sarvestani, Ivan Fernandez-Lamo, Lohith Kini, Hoameng Ung, Duygu Kuzum, Flavia Vitale, Brian Litt, Diego Contreras
New devices that use targeted electrical stimulation to treat refractory localization-related epilepsy have shown great promise, though it is not well known which targets most effectively prevent the initiation and spread of seizures. To better understand how the brain transitions from healthy to seizing on a local scale, we induced focal epileptiform activity in the visual cortex of five anesthetized cats with local application of the GABAA blocker picrotoxin while simultaneously recording local field potentials on a high-resolution electrocorticography array and laminar depth probes...
February 28, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29473644/the-atrial-fibrillation-health-literacy-information-technology-system-pilot-assessment
#20
Jared W Magnani, Courtney L Schlusser, Everlyne Kimani, Bruce L Rollman, Michael K Paasche-Orlow, Timothy W Bickmore
Background: Atrial fibrillation (AF) is a highly prevalent heart rhythm condition that has significant associated morbidity and requires chronic treatment. Mobile health (mHealth) technologies have the potential to enhance multiple aspects of AF care, including education, monitoring of symptoms, and encouraging and tracking medication adherence. We have previously implemented and tested relational agents to improve outcomes in chronic disease and sought to develop a smartphone-based relational agent for improving patient-centered outcomes in AF...
July 2017: JMIR cardio
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