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https://www.readbyqxmd.com/read/30016667/the-nmda-receptor-antagonist-radiprodil-reverses-the-synaptotoxic-effects-of-different-amyloid-beta-a%C3%AE-species-on-long-term-potentiation-ltp
#1
Gerhard Rammes, Franziska Seeser, Korinna Mattusch, Kaichuan Zhu, Laura Haas, Markus Kummer, Michael Heneka, Jochen Herms, Chris G Parsons
Aβ1-42 is well accepted to be a primary early pathogenic agent in Alzheimer's disease (AD). However, other amyloid peptides are now gaining considerable attention as potential key participants in AD due to their proposed higher neuronal toxicity. Impairment of the glutamatergic system is also widely accepted to be associated with pathomechanisms underlying AD. There is ample evidence that Aβ1-42 affects GLUN2B subunit containing N-methyl-D-aspartate receptor function and abolishes the induction of long term potentiation (LTP)...
July 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/30015940/short%C3%A2-term-use-of-atorvastatin-affects-glucose-homeostasis-and-suppresses-the-expression-of-ldl-receptors-in-the-pancreas-of-mice
#2
Qi Yu, Fang Wang, Xiaodong Meng, Yiren Gong, Yanli Wang, Cangbao Xu, Siwang Wang
Low‑density lipoprotein receptors (LDLRs) may serve a role in the diabetogenic effect of statins; however, the effects of statins on LDLR expression and its regulation in the pancreas and islets have yet to be determined. To exclude the long‑term effects of treatment with atorvastatin, which allows mice to adapt, male C57BL/j and apolipoprotein E‑deficient mice were acutely treated with oral atorvastatin for 6 weeks, and glucose homeostasis and LDLR expression in the pancreas and islets were examined...
July 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30015734/the-outcome-of-sling-retraction-technique-in-microvascular-decompression-for-hemifacial-spasm
#3
Debao Yang, Cheng Tao, Shijun Zhou, Zhimin Wang
OBJECTIVE: This study explored the technical characteristics and effectiveness of sling retraction technique in microvascular decompression for hemifacial spasm. METHODS: Between January 2008 and May 2016, 158 patients affected by hemifacial spasm underwent microvascular decompression. Among them, the traditional technique was performed in 86 patients (A Group) and the sling retraction technique was used in 72 patients (B Group). The authors conducted a retrospective study and compared the surgical outcome of the 2 groups...
July 13, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30015649/in-sickness-and-in-health-relationship-quality-and-cardiovascular-risk-and-management
#4
Heather E Tulloch, Paul S Greenman
PURPOSE OF REVIEW: To review the link between couple relationships and cardiovascular health, the plausible mechanisms by which relationship quality affects heart health, and to provide an overview of couple-based interventions aimed at improving cardiovascular health. RECENT FINDINGS: Marriage and the quality of the couple relationship bond are robust predictors of long-term health outcomes. Chronic relationship conflict and disconnection can be deadly. There are direct and indirect pathways by which couple relationship quality affect cardiovascular health...
July 13, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/30015220/the-effect-of-mannequin-fidelity-on-the-achievement-of-learning-outcomes-for-nursing-midwifery-and-allied-healthcare-practitioners-systematic-review-and-meta-analysis
#5
REVIEW
Rebecca J Sherwood, Gary Francis
BACKGROUND: Simulation has demonstrated superiority over purely didactic instruction in multiple contexts, and educationalists have embraced this modality for enhancing access to clinical skills. However, there remains uncertainty if increasing the realism (fidelity) of simulation equipment heightens performance. To address this within nursing and allied health, this review examines if increasing equipment fidelity improves learning outcomes. METHODS: A systematic search of; CINAHL, Academic Search Complete, AMED; British Education Index, ERIC, MEDLINE, PsycARTICLES, PsycINFO, Maternity and Infant Care, INTERMID, Google Scholar, American Doctoral Dissertations, EThOS, ClinicalTrials...
June 30, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/30015196/toxic-effects-of-pentachlorophenol-and-2-2-4-4-tetrabromodiphenyl-ether-on-two-generations-of-folsomia-candida
#6
Qian-Qian Zhang, Min Qiao
The standard Folsomia candida test (ISO 11267), in which only the survival and reproduction of the parental generation (F0) were determined, is insufficient to assess the toxicity of chemicals, like endocrine disrupting chemicals (EDCs), since the effects of EDCs could last for several generations and sometimes can be transgenerational. It's necessary to assess the effects on subsequent generations to address the long-term consequences of these chemicals exposure. In this study, the effects of pentachlorophenol (PCP) and 2,2',4,4'-tetrabromodiphenyl (BDE47) were assessed on F0 and the first filial generation (F1) of F...
July 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30015041/hereditary-component-of-variation-in-90-sr-deposition-in-inbred-mice-under-exogenous-conditions-that-affect-bone-formation
#7
V I Starichenko
Bone-seeking radionuclides (specifically 90 Sr) accumulate in the bone tissue and act as a long-term source of internal irradiation. Their behaviour in the body has been studied in detail, while the impact of inheritance has not been established. On one hand, the genetic determination of both skeletal morphology and calcium metabolism is indirect evidence that the kinetics of deposition of alkaline-earth radioisotopes in the skeleton also have a hereditary component. On the other hand, analysis of 90 Sr kinetics in different inbred mouse strains did not reveal any differences between the mice...
July 6, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/30014981/refinery-and-concentration-of-nutrients-from-urine-with-electrodialysis-enabled-by-upstream-precipitation-and-nitrification
#8
Jolien De Paepe, Ralph E F Lindeboom, Marjolein Vanoppen, Kim De Paepe, Dries Demey, Wout Coessens, Brigitte Lamaze, Arne R D Verliefde, Peter Clauwaert, Siegfried E Vlaeminck
Human urine is a valuable resource for nutrient recovery, given its high levels of nitrogen, phosphorus and potassium, but the compositional complexity of urine presents a challenge for an energy-efficient concentration and refinery of nutrients. In this study, a pilot installation combining precipitation, nitrification and electrodialysis (ED), designed for one person equivalent (1.2 Lurine d-1 ), was continuously operated for ∼7 months. First, NaOH addition yielded calcium and magnesium precipitation, preventing scaling in ED...
July 7, 2018: Water Research
https://www.readbyqxmd.com/read/30014767/bone-marrow-derived-monocytes-drive-the-inflammatory-microenvironment-in-local-and-remote-regions-after-thoracic-sci
#9
Diana M Norden, Timothy D Faw, Daniel B McKim, Rochelle J Deibert, Lesley C Fisher, John F Sheridan, Jonathan Phillip Godbout, D Michele Basso
Spinal cord injury (SCI) produces a toxic inflammatory microenvironment that negatively affects plasticity and recovery. Recently, we showed glial activation and peripheral myeloid cell infiltration extending beyond the epicenter through the remote lumbar cord after thoracic SCI. The presence and role of infiltrating monocytes is important, especially in the lumbar cord where locomotor central pattern generators are housed. Therefore, we compared the inflammatory profile of resident microglia and peripheral myeloid cells after SCI...
July 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30014458/identification-and-assessment-of-health-related-quality-of-life-issues-in-patients-with-sporadic-desmoid-type-fibromatosis-a-literature-review-and-focus-group-study
#10
Milea J M Timbergen, Lonneke V van de Poll-Franse, Dirk J Grünhagen, Winette T van der Graaf, Stefan Sleijfer, Cornelis Verhoef, Olga Husson
PURPOSE: Sporadic desmoid-type fibromatosis (DTF) is a rare, chronic, non-metastasising, disease of the soft tissues. It is characterised by local invasive and unpredictable growth behaviour and a high propensity of local recurrence after surgery thereby often having a great impact on health-related quality of life (HRQL). This study aims to review currently used HRQL measures and to asses HRQL issues among DTF patients. METHODS: A mixed methods methodology was used consisting of (1) a systematic literature review, according to the PRISMA guidelines (2009), using search terms related to sporadic DTF and HRQL in commonly used databases (e...
July 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/30014062/modelling-mass-balance-of-cadmium-in-paddy-soils-under-long-term-control-scenarios
#11
Wenli Feng, Zhaohui Guo, Chi Peng, Xiyuan Xiao, Lei Shi, Xiaoqing Han, Hongzhen Ran
A simple mathematical model on the basis of the mass balance principle was developed to simulate the long-term changes of Cd in paddy soils. The model predicted the dynamics of cadmium concentration in soils under six alternative control scenarios, including rice straw incorporation into fields (A), removing straw from fields (B), irrigating paddies with groundwater (C), reducing atmospheric Cd deposition (D), liming (E), and integrating measures (F), which were used for Cd contaminated paddy fields in the central subtropical areas of China...
July 17, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/30013958/improving-long-term-outcomes-after-extracorporeal-membrane-oxygenation-from-observational-follow-up-programs-toward-risk-stratification
#12
REVIEW
Hanneke IJsselstijn, Maayke Hunfeld, Raisa M Schiller, Robert J Houmes, Aparna Hoskote, Dick Tibboel, Arno F J van Heijst
Since the introduction of extracorporeal membrane oxygenation (ECMO), more neonates and children with cardiorespiratory failure survive. Interest has therefore shifted from reduction of mortality toward evaluation of long-term outcomes and prevention of morbidity. This review addresses the changes in ECMO population and the ECMO-treatment that may affect long-term outcomes, the diagnostic modalities to evaluate neurological morbidities and their contributions to prognostication of long-term outcomes. Most follow-up data have only become available from observational follow-up programs in neonatal ECMO-survivors...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30013843/stability-of-important-antibodies-for-kidney-disease-pre-analytic-methodological-considerations
#13
Qiuxia Han, Songyan Li, Bo Fu, Dongwei Liu, Maoqing Wu, Xiaoli Yang, Guangyan Cai, Zhangsuo Liu, Xiangmei Chen, Hanyu Zhu
Background: The importance of circulating antibodies as biomarkers of kidney disease has recently been recognized. However, no study has systematically described the methodology of sample preparation and storage regarding antibodies as biomarkers of kidney disease. It remains unknown whether repetitive freeze-thaw cycles, physical disturbances, storage at different temperatures or for different periods of time, or haemolytic or turbid serum samples affect antibody measurements. The aim of this study was to investigate the stabilities of antibodies associated with kidney disease in serum samples under various relevant clinical and research conditions...
2018: PeerJ
https://www.readbyqxmd.com/read/30013534/effect-of-early-weaning-on-the-intestinal-microbiota-and-expression-of-genes-related-to-barrier-function-in-lambs
#14
Chong Li, Weimin Wang, Ting Liu, Qian Zhang, Guoxiu Wang, Fadi Li, Fei Li, Xiangpeng Yue, Tingfu Li
Weaning stress has been reported to impair intestinal health. The gut microbiota plays a vital role in the long-term health of the host. However, our understanding of weaning stress on gut microbiota and barrier function is very limited in livestock species, especially lambs. We investigated the effects of early weaning stress on intestinal bacterial communities and intestinal barrier function in lambs. A total of 24 neonatal male Hu lambs were randomly allocated into two groups, one weaned on day 28 and the other weaned on day 56...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30013332/the-effect-of-positive-changes-during-intraoperative-monitoring-of-the-functional-improvement-in-patients-with-cervical-compressive-myelopathy
#15
Min Kyu Park, Sook Joung Lee, Sang Beom Kim, Kyeong Woo Lee, Hye-Jeong Lee, Eun Young Han, Bo Ryun Kim
Background: Cervical compressive myelopathy (CCM) is a progressive, degenerative spine disease and the most common cause of spinal cord dysfunction in older individuals. Current clinical guidelines for spinal surgery recommend multimodal intraoperative monitoring (IOM) during spinal surgery as a reliable and valid diagnostic adjunct to assess spinal cord integrity. The aim of this study was to evaluate the effect of positive changes during IOM on the functional status in patients with CCM...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/30013169/author-correction-pv-plasticity-sustained-through-d1-5-dopamine-signaling-required-for-long-term-memory-consolidation
#16
Smitha Karunakaran, Ananya Chowdhury, Flavio Donato, Charles Quairiaux, Christoph M Michel, Pico Caroni
In the version of this article initially published, the right panel in Fig. 2b was duplicated from the corresponding panel in Fig. 2c, and some data points in Fig. 3b were duplicated from Fig. 3a. None of the conclusions in the paper are affected. The errors have been corrected in the HTML and PDF versions of the article, and source data have been posted for the revised panels. The original and corrected figures are shown in the accompanying Author Correction.
July 16, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/30013021/graft-regeneration-and-functional-recovery-in-patients-with-early-allograft-dysfunction-after-living-donor-liver-transplantation
#17
Min Suk Chae, Youngchan Kim, Nuri Lee, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sanghyun Hong
BACKGROUND Successful graft regeneration is important in living-donor liver transplantation (LDLT) because partial liver grafts are used. Early allograft dysfunction (EAD) is an intermediate outcome that affects the long-term postoperative course in liver transplantation. The aim of the present study was to investigate liver graft regeneration under EAD development in LDLT. MATERIAL AND METHODS The data of 226 patients who underwent LDLT from September 2010 to July 2014 were retrospectively analyzed. The patients were classified into 2 groups: one with and one without EAD...
July 17, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30012879/preserved-capacity-for-scene-construction-and-shifts-in-perspective-after-hippocampal-lesions
#18
Nuttida Rungratsameetaweemana, Larry R Squire
The hippocampus has long been recognized as important for the formation of long-term memory. Recent work has suggested that the hippocampus might also be important for certain kinds of spatial operations, as in constructing scenes, shifting perspective, or perceiving the geometry of scenes and their boundaries. We explored this proposal using a task similar to one used previously that related hippocampal activity to scenes and their boundaries. In our study, participants viewed scenes from above that displayed walls and towers...
August 2018: Learning & Memory
https://www.readbyqxmd.com/read/30012770/novel-potent-capsid-assembly-modulators-regulate-multiple-steps-of-the-hepatitis-b-virus-life-cycle
#19
Thomas Lahlali, Jan Martin Berke, Karen Vergauwen, Adrien Foca, Koen Vandyck, Frederik Pauwels, Fabien Zoulim, David Durantel
The assembly of hepatitis B virus (HBV) core proteins (HBc) into capsids represents a critical step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it an attractive target for antiviral therapies. Capsid assembly modulators (CAMs) induce the formation of empty-capsid or aberrant-capsid devoid of pregenomic RNA (pgRNA) and finally block rcDNA neosynthesis and virion progeny. In this study, novel CAMs JNJ-827 and JNJ-890, were found to be potent inhibitors of HBV replication with a respective half maximal effective concentration of 4...
July 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30012688/perinatal-exposure-to-an-environmentally-relevant-mixture-of-phthalates-results-in-a-lower-number-of-neurons-and-synapses-in-the-medial-prefrontal-cortex-and-decreased-cognitive-flexibility-in-adult-male-and-female-rats
#20
Daniel G Kougias, Elli P Sellinger, Jari Willing, Janice M Juraska
The growth and organization of the developing brain is known to be influenced by hormones, but little is known about whether disruption of hormones affects cortical regions, like the medial prefrontal cortex (mPFC). This region is particularly important given its involvement in executive functions and implication in the pathology of many neuropsychiatric disorders. Here, we examine the long-term effects of perinatal exposure to endocrine-disrupting compounds, the phthalates, on the mPFC and associated behavior...
July 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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