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https://www.readbyqxmd.com/read/28222265/modeling-soluble-and-particulate-lead-release-into-drinking-water-from-full-and-partially-replaced-lead-service-lines
#1
Ahmed A Abokifa, Pratim Biswas
Partial replacement of lead service lines (LSLs) often results in the excessive long-term release of lead particulates due to the disturbance of pipe scale and galvanic corrosion. In this study, a modeling approach to simulate the release and transport of particulate and dissolved lead from full and partially replaced LSLs is developed. A mass transfer model is coupled with a stochastic residential water demand generator to investigate the effect of normal household usage (NHU) flow patterns on lead exposure...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28222069/patients-perceptions-of-the-negative-effects-following-different-prostate-cancer-treatments-and-the-impact-on-psychological-well-being-a-nationwide-survey
#2
Ulla-Sisko Lehto, Heli Tenhola, Kimmo Taari, Arpo Aromaa
BACKGROUND: Although the prognosis of localised prostate cancer is good, the negative effects of prostate cancer treatment often impair patient quality of life. A growing number of men experience these negative effects over a longer time because of the increased incidence of and prolonged survival in prostate cancer, and the ageing of the population. Only a few studies have investigated the adverse effects of different prostate cancer treatments using large population-based samples. METHODS: We conducted a nationwide survey (n=1239) to collect detailed information regarding the negative effects (i...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28221088/the-menstrual-cycle-response-and-developmental-affective-risk-model-a-multilevel-and-integrative-model-of-influence
#3
Jeff Kiesner
An integrative developmental model is presented in which menstrual cycle-related symptoms are hypothesized to result in a cascade of developmental challenges that contribute to increased affective symptoms among adolescent girls, and to long-term developmental sequelae. To provide the basis for this model a broad foundation is developed considering (a) psychological symptoms and disorders associated with reproductive events across the life span, and (b) the many and complicated effects that female reproductive steroids (estrogen & progesterone) have which trigger a variety of physical and psychological changes that are commonly associated with the menstrual cycle...
March 2017: Psychological Review
https://www.readbyqxmd.com/read/28220959/evaluating-clinical-dietary-and-psychological-risk-factors-for-relapse-of-ulcerative-colitis-in-clinical-endoscopic-and-histological-remission
#4
Rajan Dhingra, Saurabh Kedia, Pratap Mouli Venigalla, Sushil Kumar, Namrata Singh, Sawan Bopanna, Vikas Singla, Bikash Narayan Choudhury, Prashant Verma, Veena Tiwari, Siddhartha Datta Gupta, Govind Makharia, Vineet Ahuja
BACKGROUND: The literature on possible factors that could trigger a relapse in patients with ulcerative colitis (UC) in clinical, endoscopic and histological remission on long term follow up is scarce. AIM: To determine the relapse rate in patients with UC in clinical, endoscopic and histological remission and identify factors that may influence the risk of relapse. METHODS: Patients with UC in clinical, endoscopic and histological remission were enrolled between January-July 2010 and followed up for 1 year to determine the effect of clinical, dietary and psychological factors on relapse...
February 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28220905/mobile-phone-use-and-risk-for-intracranial-tumors-and-salivary-gland-tumors-a-meta-analysis
#5
REVIEW
Alicja Bortkiewicz, Elżbieta Gadzicka, Wiesław Szymczak
Results of epidemiological studies on the association between use of mobile phone and brain cancer are ambiguous, as well as the results of 5 meta-analysis studies published to date. Since the last meta-analysis (2009), new case-control studies have been published, which theoretically could affect the conclusions on this relationship. Therefore, we decided to perform a new meta-analysis. We conducted a systematic review of multiple electronic data bases for relevant publications. The inclusion criteria were: original papers, case-control studies, published till the end of March 2014, measures of association (point estimates as odds ratio and confidence interval of the effect measured), data on individual exposure...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220870/long-term-use-of-ceftriaxone-sodium-induced-changes-in-gut-microbiota-and-immune-system
#6
Yanjie Guo, Xuefei Yang, Yane Qi, Shu Wen, Yinhui Liu, Shaoying Tang, Rongsheng Huang, Li Tang
Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice received saline or different doses of ceftriaxone sodium (100, 200 and 400 mg/mL) via daily gavage for 150 days. Alterations of fecal microbiota, small intestine histopathology, body weight, spleen index, serum IgG, mucus SIgA, IFN-γ/IL-4 ratio, CD4/CD8 ratio and CD4(+)CD25(+) cells were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220263/characterization-and-outcome-of-41-patients-with-beta-ketothiolase-deficiency-10%C3%A2-years-experience-of-a-medical-center-in-northern-vietnam
#7
Khanh Ngoc Nguyen, Elsayed Abdelkreem, Roberto Colombo, Yuki Hasegawa, Ngoc Thi Bich Can, Thao Phuong Bui, Hai Thanh Le, Mai Thi Chi Tran, Hoan Thi Nguyen, Hung Thanh Trinh, Yuka Aoyama, Hideo Sasai, Seiji Yamaguchi, Toshiyuki Fukao, Dung Chi Vu
Beta-ketothiolase (T2) deficiency is an inherited disease of isoleucine and ketone body metabolism caused by mutations in the ACAT1 gene. Between 2005 and 2016, a total of 41 patients with T2 deficiency were identified at a medical center in northern Vietnam, with an estimated incidence of one in 190,000 newborns. Most patients manifested ketoacidotic episodes of varying severity between 6 and 18 months of age. Remarkably, 28% of patients showed high blood glucose levels (up to 23.3 mmol/L). Ketoacidotic episodes recurred in 43% of patients...
February 20, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28220112/predominance-of-viable-spore-forming-piezophilic-bacteria-in-high-pressure-enrichment-cultures-from-1-5-to-2-4-km-deep-coal-bearing-sediments-below-the-ocean-floor
#8
Jiasong Fang, Chiaki Kato, Gabriella M Runko, Yuichi Nogi, Tomoyuki Hori, Jiangtao Li, Yuki Morono, Fumio Inagaki
Phylogenetically diverse microorganisms have been observed in marine subsurface sediments down to ~2.5 km below the seafloor (kmbsf). However, very little is known about the pressure-adapted and/or pressure-loving microorganisms, the so called piezophiles, in the deep subseafloor biosphere, despite that pressure directly affects microbial physiology, metabolism, and biogeochemical processes of carbon and other elements in situ. In this study, we studied taxonomic compositions of microbial communities in high-pressure incubated sediment, obtained during the Integrated Ocean Drilling Program (IODP) Expedition 337 off the Shimokita Peninsula, Japan...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28219966/the-child-witness-in-the-courtroom
#9
Robert H Pantell
Beginning in the 1980s, children have increasingly served as witnesses in the criminal, civil, and family courts; currently, >100 000 children appear in court each year. This statement updates the 1992 American Academy of Pediatrics (AAP) policy statement "The Child as a Witness" and the subsequent 1999 "The Child in Court: A Subject Review." It also builds on existing AAP policy on adverse life events affecting children and resources developed to understand and address childhood trauma. The purpose of this policy statement is to provide background information on some of the legal issues involving children testifying in court, including the accuracy and psychological impact of child testimony; to provide suggestions for how pediatricians can support patients who will testify in court; and to make recommendations for policy improvements to minimize the adverse psychological consequences for child witnesses...
February 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28219933/akt-signalling-as-a-mediator-of-cardiac-adaptation-to-low-birth-weight
#10
Kimberley Cw Wang, Kimberley J Botting, Song Zhang, Caroline McMillen, Doug A Brooks, Janna L Morrison
Intrauterine insults, such as poor nutrition and placental insufficiency, can alter cardiomyocyte development and this can have significant long-term implications for heart health. Consequently, epidemiological studies have shown that low birth weight babies have an increased risk of death from cardiovascular disease in adult life. In addition, intrauterine growth restriction can result in increased left ventricular hypertrophy, which is the strongest predictor for poor health outcomes in cardiac patients. The mechanisms responsible for these associations are not clear, but a suboptimal intrauterine environment can program alternative expression of genes such as cardiac IGF-2/H19, IGF-2R and AT1R through either an increase or decrease in DNA methylation or histone acetylation at specific loci...
February 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28219879/use-of-online-forums-for-perinatal-mental-illness-stigma-and-disclosure-an-exploratory-model
#11
Donna Moore, Nicholas Drey, Susan Ayers
BACKGROUND: Perinatal mental illness is a global health concern; however, many women with the illness do not get the treatment they need to recover. Interventions that reduce the stigma around perinatal mental illness have the potential to enable women to disclose their symptoms to health care providers and consequently access treatment. There are many online forums for perinatal mental illness and thousands of women use them. Preliminary research suggests that online forums may promote help-seeking behavior, potentially because they have a role in challenging stigma...
February 20, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28219430/digital-health-system-for-personalised-copd-long-term-management
#12
Carmelo Velardo, Syed Ahmar Shah, Oliver Gibson, Gari Clifford, Carl Heneghan, Heather Rutter, Andrew Farmer, Lionel Tarassenko
BACKGROUND: Recent telehealth studies have demonstrated minor impact on patients affected by long-term conditions. The use of technology does not guarantee the compliance required for sustained collection of high-quality symptom and physiological data. Remote monitoring alone is not sufficient for successful disease management. A patient-centred design approach is needed in order to allow the personalisation of interventions and encourage the completion of daily self-management tasks...
February 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28219113/personality-coping-and-social-support-as-predictors-of-long-term-quality-of-life-trajectories-in-older-breast-cancer-survivors-calgb-protocol-369901-alliance
#13
Estrella Durá-Ferrandis, Jeanne S Mandelblatt, Jonathan Clapp, George Luta, Leigh Anne Faul, Gretchen Kimmick, Harvey J Cohen, Rachel L Yung, Arti Hurria
OBJECTIVE: To determine long-term quality-of-life (QoL) trajectories among breast cancer survivors aged 65+ ("older") evaluating the effects of personality and social support. METHODS: Older women (N = 1280) newly diagnosed with invasive, non-metastatic breast cancer completed baseline assessments. Follow-up data were collected 6 and 12 months later and then annually for up to 7 years (median 4.5 years). QoL was assessed using EORTC-QLQC30 emotional, physical, and cognitive scales...
February 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28219103/digoxin-induces-cardiac-hypertrophy-without-negative-effects-on-cardiac-function-and-physical-performance-in-trained-normotensive-rats
#14
Claodete Hasselstrom Neves, Ramires Alsamir Tibana, Jonato Prestes, Fabricio Azevedo Voltarelli, Andreo Fernando Aguiar, Gustavo Augusto Ferreira Mota, Sergio Luiz Borges de Sousa, Andre Soares Leopoldo, Ana Paula Lima Leopoldo, Andre Mueller, Danilo Henrique Aguiar, James Wilfred Navalta, Mario Mateus Sugizaki
Cardiotonic drugs and exercise training promote cardiac inotropic effects, which may affect training-induced cardiac adaptations. This study investigated the effects of long-term administration of digoxin on heart structure and function, and physical performance of rats submitted to high-intensity interval training (HIIT). Male Wistar rats, 60 days old, were divided into control (C), digoxin (DIGO), trained (T), and trained with digoxin (TDIGO). Digoxin was administered by gavage (30 µg/kg/day) for 75 days...
February 20, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28219061/establishing-prenatal-surgery-for-myelomeningocele-in-asia-the-singapore-consensus
#15
Tuangsit Wataganara, Suresh Seshadri, Tak Yeung Leung, Citra Matter, Monawat Ngerncham, Namtip Triyasunant, Padmakar Vidyadhar Mali, Agnhitori Biswas, Katika Nawapun, Nisarat Phithakwatchara, Alan W Flake, Mark P Johnson, Arijit Biswas, Mahesh Choolani
OBJECTIVES: The Management of Myelomeningocele Study (MOMS Trial) has inspired many fetal therapy centers (FTCs) to offer open fetal surgery for myelomeningocele (MMC). This is an initial effort to create a candidate model that can be applicable to many parts of Asia. MATERIAL AND METHODS: A limited selection of specialists from 4 established FTCs in Thailand, Hong Kong, India, and Singapore met for a round table discussion. Experts from Children's Hospital of Philadelphia (CHOP) involved in the Trial moderated the session...
February 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28218990/renal-function-at-one-year-after-cardiac-transplantion-rather-than-acute-kidney-injury-is-highly-associated-with-long-term-patient-survival-and-loss-of-renal-function
#16
Gijs Fortrie, Olivier C Manintveld, Alina A Constantinescu, Pieter C van de Woestijne, Michiel G H Betjes
BACKGROUND: The current study aims to assess the association between acute kidney injury (AKI), renal function one year after transplantation and long-term adverse outcomes after cardiac transplantation. METHODS: A retrospective cohort study was performed including 471 adult cardiac transplantation recipients that survived the first postoperative year between 1984 and 2012. Primary outcome variables were long-term overall and renal survival. RESULTS: During the first postoperative week 40% (n=288) of the recipients developed AKI stage I, 22% (n=104) stage II, 13% (n=63) stage III and 4% (n=17) required temporary RRT...
February 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28218953/glial-papillary-tumour-of-the-spinal-cord-with-smarcb1-ini1-loss-and-favourable-long-term-outcome
#17
Martin Hasselblatt, Anastasia Dewi Kurniawan, Stephanie Rozsnoki, Pascal D Johann, Susanne Bens, Florian Oyen, Reinhard Schneppenheim, Reiner Siebert, David Capper, Marcel Kool, Christoph Schul, Werner Paulus
Rhabdoid phenotype and biallelic mutations of the SMARCB1 gene causing loss of SMARCB1/INI1 protein expression are the hallmark of atypical teratoid/rhabdoid tumour (AT/RT), a highly malignant central nervous system tumour mainly affecting infants [1]. Loss of SMARCB1/INI1 protein expression has also been described in a variety of other rhabdoid and non-rhabdoid tumour entities including cribriform neuroepithelial tumour (CRINET) [2], poorly differentiated chordoma [3] as well as rhabdoid peripheral nerve sheath tumour [4] and familial schwannomatosis [5]...
February 20, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28218871/a-systematic-review-of-influences-on-development-of-athletes-with-disabilities
#18
Nima Dehghansai, Srdjan Lemez, Nick Wattie, Joseph Baker
Compared with mainstream sport athletes, relatively little is known regarding the factors affecting the development of athletes with a disability. Sport-specific training programs are essential to athletes' successful performance; to create appropriate programs and strategies, a clear understanding of the nuances of development of athletes with a disability is important. The objective of this systematic review was to synthesize existing research on development in athletes with a disability and examine the key determinants of successful development and sporting performance...
January 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28218646/impact-of-consuming-toxic-monarch-caterpillars-on-adult-chinese-mantid-mass-gain-and-fecundity
#19
Jamie L Rafter, Liahna Gonda-King, Daniel Niesen, Navindra P Seeram, Chad M Rigsby, Evan L Preisser
Predators that feed on chemically-defended prey often experience non-lethal effects that result in learned avoidance of the prey species. Some predators are able to consume toxic prey without ill-effect. The Chinese mantid is able to consume cardenolide-containing monarch caterpillars without immediate adverse effects. Although they discard the caterpillars' gut contents, mantids consume sequestered cardenolides. Although consumption of these cardenolides does not elicit an acute response, there may be long-term costs associated with cardenolide consumption...
February 17, 2017: Insects
https://www.readbyqxmd.com/read/28218337/long-term-outcome-after-reperfusion-treated-stroke
#20
Oscar Mühr, Hanna C Persson, Katharina S Sunnerhagen
OBJECTIVE: To explore motor function, health-related quality of life and impact on activities of daily living 5 and 6 years after reperfusion treatment in patients with stroke. METHODS: A total of 75 patients with first-time stroke received either thrombectomy or thrombolytic treatment at the Sahlgrenska University Hospital in Gothenburg during an 18-month period in 2009-2010. Follow-up involved questionnaires and clinical examinations, 5 and 6 years post-stroke...
February 17, 2017: Journal of Rehabilitation Medicine
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