keyword
MENU ▼
Read by QxMD icon Read
search

Long term affects

keyword
https://www.readbyqxmd.com/read/28454389/notch-signaling-is-important-for-epithelial-mesenchymal-transition-induced-by-low-concentrations-of-doxorubicin-in-osteosarcoma-cell-lines
#1
Jian Yang, Weichun Guo, Lu Wang, Ling Yu, Hongjun Mei, Shuo Fang, Anyuan Chen, Yang Liu, Kezhou Xia, Gaiwei Liu
Osteosarcoma is an aggressive pediatric tumor affecting growing bones that typically occurs in adolescents and young adults. Although advances in treatment have been made in recent years, a high proportion of patients relapse due to metastases, which are frequently resistant to chemotherapy and pose a significant threat to long-term survival. Previous studies have demonstrated that the epithelial-mesenchymal transition (EMT) is associated with cancer occurrence and metastasis, and our previous study demonstrated the occurrence of EMT in osteosarcoma...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454228/prognostic-factors-of-long-term-outcome-in-surgically-resectable-pancreatic-neuroendocrine-tumors-a-12-year-experience-from-a-single-center
#2
Bo Zhou, Jixuan Duan, Sheng Yan, Jie Zhou, Shusen Zheng
The present study was performed to assess the prognostic factors with respect to patient survival and clinicopathological characteristics for patients who underwent surgery for pancreatic neuroendocrine tumors (PNETs). A retrospective review of patients pathologically diagnosed with PNETs at the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, Zhejiang, China) between September 2002 and September 2013 was conducted. The clinicopathological findings, overall survival (OS) rate and disease-free survival (DFS) rate of the patients with PNETs were analyzed...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454041/long-term-intake-of-a-high-protein-diet-increases-liver-triacylglycerol-deposition-pathways-and-hepatic-signs-of-injury-in-rats
#3
Rubén Díaz-Rúa, Jaap Keijer, Andreu Palou, Evert M van Schothorst, Paula Oliver
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathways affected by long-term intake of an HP diet. We performed a transcriptome analysis on liver of rats chronically fed with a casein-rich HP diet and analyzed molecular parameters related to liver injury. Chronic increase in the dietary protein/carbohydrate ratio up-regulated processes related with amino acid uptake/metabolism and lipid synthesis, promoting a molecular environment indicative of hepatic triacylglycerol (TG) deposition...
April 19, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28453797/coronary-artery-bypass-surgery-in-young-adults-excellent-perioperative-results-and-long-term-survival
#4
Joana Saraiva, Pedro E Antunes, Manuel J Antunes
OBJECTIVES: To analyse perioperative results, long-term survival and freedom from complications after coronary artery bypass grafting (CABG) in young adults. METHODS: A total of 163 patients, 40 years old or younger, had isolated CABG from January 1989 to December 2010. Pre- and perioperative demographic and clinical data were retrieved from a prospectively organised database. Follow-up data were obtained by letter or telephone interviews. The mean age of the patients was 37...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453558/tumor-targeted-sn38-inhibits-growth-of-early-stage-non-small-cell-lung-cancer-nsclc-in-a-kras-p53-transgenic-mouse-model
#5
Alexander Y Deneka, Leora Haber, Meghan C Kopp, Anna V Gaponova, Anna S Nikonova, Erica A Golemis
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide, with a 5-year survival of only ~16%. Potential strategies to address NSCLC mortality include improvements in early detection and prevention, and development of new therapies suitable for use in patients with early and late stage diagnoses. Controlling the growth of early stage tumors could yield significant clinical benefits for patients with comorbidities that make them poor candidates for surgery: however, many drugs that limit cancer growth are not useful in the setting of long-term use or in comorbid patients, because of associated toxicities...
2017: PloS One
https://www.readbyqxmd.com/read/28453486/cognitive-deficits-after-cerebral-ischemia-and-underlying-dysfunctional-plasticity-potential-targets-for-recovery-of-cognition
#6
Holly M Stradecki-Cohan, Charles H Cohan, Ami P Raval, Kunjan R Dave, Diego Reginensi, Rolando A Gittens, Mehdi Youbi, Miguel A Perez-Pinzon
Cerebral ischemia affects millions of people worldwide and survivors suffer from long-term functional and cognitive deficits. While stroke and cardiac arrest are typically considered when discussing ischemic brain injuries, there is much evidence that smaller ischemic insults underlie neurodegenerative diseases, including Alzheimer's disease. The "regenerative" capacity of the brain relies on several aspects of plasticity that are crucial for normal functioning; less affected brain areas may take over function previously performed by irreversibly damaged tissue...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28449459/endovascular-repair-of-residual-intimal-tear-or-distal-new-entry-after-frozen-elephant-trunk-for-type-a-aortic-dissection
#7
Xu-Dong Pan, Bin Li, Wei-Guo Ma, Jun Zheng, Yong-Min Liu, Jun-Ming Zhu, Lian-Jun Huang, Li-Zhong Sun
BACKGROUND: In patients with type A dissection, residual dissection and new distal entry tears following the frozen elephant trunk (FET) procedure adversely affect long-term prognosis. Management include open and endovascular repair, while clinical experience is limited. We evaluate the efficacy of thoracic endovascular aortic repair (TEVAR) in management of residual intimal tear or distal new entry tear following FET in patients with type A aortic dissection (TAAD). METHODS: Between May 2003 and April 2013, we performed FET and total arch replacement for 1,003 patients with TAAD...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449272/adalimumab-is-a-safe-option-for-psoriasis-patients-with-concomitant-hepatitis-b-or-c-infection-a-multicentre-cohort-study-of-37-patients-and-review-of-the-literature-%C3%A2-reply-to-dr-ricceri-letter
#8
Stefano Piaserico
We thank Ricceri et al. for their comments (1) and interest in our study (2). Despite the recent advances in prevention and treatment of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, these two chronic infections still represent the most common cause of chronic liver disease. Dermatologists are frequently encountering patients with psoriatic disease who have concomitant HBV or HCV infection in daily clinical practice. Dr Ricceri provided in his letter further long-term follow-up data (60 months) on the use of etanercept or adalimumab in 17 psoriatic patients affected by past HBV infection or chronic HCV infection...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28449223/the-impact-of-a-sibling-s-life-limiting-genetic-condition-on-adult-brothers-and-sisters
#9
Erica Brown, Jane Coad, Anita Franklin
It is estimated that rare diseases affect the lives of over three million people in the United Kingdom. Of these, a significant proportion are children and young people with genetic life-limiting or life-shortening conditions. This study used a qualitative approach with in-depth semi-structured interviews to explore the experiences of 10 adult siblings of a baby diagnosed with Trisomy 13 (Patau syndrome) or Trisomy 18 (Edward syndrome). Findings illustrate that parental grief from the time of their child's diagnosis onward is also experienced by siblings...
April 27, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28449189/reply-adalimumab-is-a-safe-option-for-psoriasis-patients-with-concomitant-hepatitis-b-or-c-infection-a-multicentre-cohort-study-of-37-patients-and-review-of-the-literature
#10
F Ricceri, L Pescitelli, L Lazzeri, A Di Cesare, F Prignano
We have read with interest the article by Piaserico et al. concerning the use of tumour necrosis factor-alpha (TNF-alpha) blocking agent adalimumab in psoriatic patients with concomitant hepatitis B virus (HBV) or hepatitis C virus (HCV). The authors describe 17 psoriatic patients affected by chronic HBV infection and 20 affected by chronic HCV who were successfully treated with adalimumab with no evidence of HBV or HCV reactivation in a mean follow-up period of 27 and 40 months, respectively. We have previously described our successful experience of treatment with anti-TNF-alpha therapy in 17 psoriatic patients (11 with past HBV infection, 5 with chronic HCV infection and one affected by both HBV and HCV) without the use of lamivudine or adenofovir, and can now report on long-term follow-up data (mean follow-up period of 60 months)...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28449121/tri-directional-anaphases-as-a-novel-chromosome-segregation-defect-in-human-oocytes
#11
Jenna Haverfield, Nicola L Dean, Diana Nöel, Gaudeline Rémillard-Labrosse, Veronique Paradis, Isaac-Jacques Kadoch, Greg FitzHarris
STUDY QUESTION: What are the chromosome segregation errors in human oocyte meiosis-I that may underlie oocyte aneuploidy? SUMMARY ANSWER: Multiple modes of chromosome segregation error were observed, including tri-directional anaphases, which we attribute to loss of bipolar spindle structure at anaphase-I. WHAT IS KNOWN ALREADY: Oocyte aneuploidy is common and associated with infertility, but mechanistic information on the chromosome segregation errors underlying these defects is scarce...
April 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28448920/the-effect-of-equiaxial-stretching-on-the-osteogenic-differentiation-and-mechanical-properties-of-human-adipose-stem-cells
#12
Sanni Virjula, Feihu Zhao, Joni Leivo, Sari Vanhatupa, Joose Kreutzer, Ted J Vaughan, Anna-Maija Honkala, Marlitt Viehrig, Conleth A Mullen, Pasi Kallio, Laoise M McNamara, Susanna Miettinen
Although mechanical cues are known to affect stem cell fate and mechanobiology, the significance of such stimuli on the osteogenic differentiation of human adipose stem cells (hASCs) remains unclear. In this study, we investigated the effect of long-term mechanical stimulation on the attachment, osteogenic differentiation and mechanical properties of hASCs. Tailor-made, pneumatic cell stretching devices were used to expose hASCs to cyclic equiaxial stretching in osteogenic medium. Cell attachment and focal adhesions were visualised using immunocytochemical vinculin staining on days 3 and 6, and the proliferation and alkaline phosphatase activity, as a sign of early osteogenic differentiation, were analysed on days 0, 6 and 10...
April 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28448718/cannabis-use-by-women-during-pregnancy-does-not-influence-infant-dna-methylation-of-the-dopamine-receptor-drd4
#13
Peter D Fransquet, Delyse Hutchinson, Craig A Olsson, Steve Allsop, Elizabeth J Elliott, Lucinda Burns, Richard Mattick, Richard Saffery, Joanne Ryan
BACKGROUND: Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between cannabis use and offspring DNA methylation have not been investigated; however, maternal tobacco smoking in pregnancy is associated with distinct patterns of DNA methylation at birth and beyond. OBJECTIVES: To determine whether maternal cannabis use is associated with methylation of the dopamine receptor gene DRD4 promoter in infants...
April 27, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28448277/long-term-consequences-of-obesity-on-female-fertility-and-the-health-of-the-offspring
#14
Suchitra Chandrasekaran, Genevieve Neal-Perry
PURPOSE OF REVIEW: Obesity has reached near epidemic levels among reproductive age women with a myriad of consequences. Obesity adversely affects the maternal milieu by creating conditions that decrease fertility and increase the risk of gestational diabetes, hypertensive disease in pregnancy, fetal growth abnormalities and congenital anomalies. The effects of obesity are not limited to pregnancy. Indeed, beyond the immediate postpartum period, obese women maintain a higher prevalence of insulin resistance and cardiovascular disease...
April 26, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28447864/the-use-of-cyproterone-acetate-ethinyl-estradiol-in-hyperandrogenic-skin-symptoms-a-review
#15
J Bitzer, T Römer, A Lopes da Silva Filho
INTRODUCTION: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28447816/does-combat-exposure-affect-well-being-in-later-life-the-va-normative-aging-study
#16
Hyunyup Lee, Carolyn M Aldwin, Soyoung Choun, Avron Spiro
OBJECTIVE: Combat exposure can have long-term negative effects in later life; although aspects of service may be appraised positively, the long-term positive effects of combat on well-being in later life is largely unknown. METHOD: The sample included 1,006 male veterans from the VA Normative Aging Study, surveyed by mail in 1986, 1990, and 1991 (Mage = 65.5 years, SD = 7.3). They reported on their combat exposure, desirable appraisals of military service, unit cohesion, dispositional optimism, self-rated health, and psychological well-being (PWB), as well as age, military rank, and education...
April 27, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28447574/optimized-longitudinal-monitoring-of-stem-cell-grafts-in-mouse-brain-using-a-novel-bioluminescent-near-infrared-fluorescent-fusion-reporter
#17
Laura Mezzanotte, Juvita Delancy Iljas, Ivo Que, Alan Chan, Eric Kaijzel, Rob Hoeben, Clemens Löwik
<p>Biodistribution and fate of transplanted stem cells via longitudinal monitoring has been successfully achievedin the last decade using optical imaging. However, sensitive longitudinal imaging of transplanted stem cells in deep tissue like the brain remains challenging not only due to low light penetration but because of other factors such as low or inferior expression levels of optical reporters in stem cells and stem cell death after transplantation. Here we describe an optimized imaging protocol for sensitive long term monitoring of human bone marrow derived mesenchymal stem cells (hMSCs) expressing a novel bioluminescent/near infrared fluorescent (NIRF) fusion reporter transplanted in mouse brain cortex...
April 26, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28447127/bone-adaptation-of-a-biologically-reconstructed-femur-after-ewing-sarcoma-long-term-morphological-and-densitometric-evolution
#18
Giordano Valente, Fulvia Taddei, Andrea Roncari, Enrico Schileo, Marco Manfrini
Combining bone allografts and vascularized fibular autografts in intercalary reconstructions after resection of bone sarcomas is of particular interest in young patients as it facilitates bone healing and union and helps reduce fractures. However, adverse events related to bone adaptation still occur. Bone adaptation is driven by mechanical loading, but no quantitative biomechanical studies exist that would help surgical planning and rehabilitation. We analyzed the bone adaptation of a successful femoral reconstruction after Ewing sarcoma during 76-month follow-up using a novel methodology that allows CT-based quantification of morphology and density...
April 26, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28447080/doping-of-nematic-cyanobiphenyl-liquid-crystals-with-mesogen-hybridized-magnetic-nanoparticles
#19
Ingo Appel, Hajnalka Nádasi, Christian Reitz, Nerea Sebastián, Horst Hahn, Alexey Eremin, Ralf Stannarius, Silke S Behrens
Magnetic nanoparticles (MNPs) functionalized with (pro-)mesogenic ligands are implemented into a nematic liquid crystal (LC) and studied regarding both colloidal stability and magneto-optical behavior. In this study, the particle surface is specifically engineered to tune the MNP interactions with the LC host. For this purpose, four types of (pro-)mesogenic ligands (ML) are synthesized, which are composed of three structural parts, i.e., a rigid, LC motif (i.e., cyanobiphenyl) and a functional group for nanoparticle binding, both linked via a flexible spacer of different alkyl chain lengths...
April 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28446701/wind-and-rain-are-the-primary-climate-factors-driving-changing-phenology-of-an-aerial-insectivore
#20
Rachel D Irons, April Harding Scurr, Alexandra P Rose, Julie C Hagelin, Tricia Blake, Daniel F Doak
While the ecological effects of climate change have been widely observed, most efforts to document these impacts in terrestrial systems have concentrated on the impacts of temperature. We used tree swallow (Tachycineta bicolor) nest observations from two widely separated sites in central Alaska to examine the aspects of climate affecting breeding phenology at the northern extent of this species' range. We found that two measures of breeding phenology, annual lay and hatch dates, are more strongly predicted by windiness and precipitation than by temperature...
April 26, 2017: Proceedings. Biological Sciences
keyword
keyword
1006
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"