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https://www.readbyqxmd.com/read/28346762/predicting-the-pain-continuum-after-adolescent-idiopathic-scoliosis-surgery-a-prospective-cohort-study
#1
V Chidambaran, L Ding, D L Moore, K Spruance, E M Cudilo, V Pilipenko, M Hossain, P Sturm, S Kashikar-Zuck, L J Martin, S Sadhasivam
BACKGROUND: Chronic postsurgical pain (CPSP) affects half a million children annually in the United States, with dire socioeconomic consequences, including long-term disability into adulthood. The few studies of CPSP in children are limited by sample size, follow-up duration, non-homogeneity of surgical procedure and factors evaluated. METHODS: In a prospective study of 144 adolescents undergoing a single major surgery (spine fusion), we evaluated demographic, perioperative, surgical and psychosocial factors as predictors of a continuum of postsurgical pain: immediate, pain maintenance at 2-3 months (chronic pain/CP) and persistence of pain a year (persistent pain/PP) after surgery...
March 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28346386/a-mixed-methods-examination-of-physical-activity-and-sedentary-time-in-overweight-and-obese-south-asian-men-living-in-the-united-kingdom
#2
Amir Emadian, Janice Thompson
South Asian men living in the UK have higher rates of central obesity and Type 2 Diabetes Mellitus (T2DM) compared with their white British counterparts. Physical activity (PA) and sedentary time (ST) are important risk factors for the development of T2DM. The purpose of this study was to objectively measure PA, ST, and to explore the factors influencing these behaviours in this high-risk population. A mixed-methods cross-sectional research design was employed, including the quantification of PA and ST using the self-report International Physical Activity Questionnaire (IPAQ)-long form and accelerometry in overweight and obese UK South Asian men (n = 54), followed by semi-structured interviews in a purposive sub-sample to explore the factors influencing PA and ST (n = 31)...
March 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28345979/assessment-and-treatment-options-for-patients-with-constipation
#3
Alison Bardsley
Constipation is a common complaint for people of all ages, with prevalence increasing with age and during pregnancy. Women are more likely to be affected than men. Severity of constipation varies from person to person; most people experience short periods of constipation during their lives, including possibly after surgery, while others have constipation as a chronic long-term condition that can significantly affect their quality of life. There are a number of factors that can contribute to developing constipation including diets low in fibre, changes in lifestyle, side effects of certain medications and low fluid intake...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345900/fluorescence-and-radio-labeling-of-lys-4-nle-17-30-hpp-yields-molecular-tools-for-the-npy-y4-receptor
#4
Stefanie Dukorn, Timo Littmann, Max Keller, Kilian Konrad Kuhn, Chiara Cabrele, Paul Baumeister, Günther Bernhardt, Armin Buschauer
The neuropeptide Y (NPY) Y4 receptor (Y4R) is involved in energy homeostasis and considered as a potential drug target for the treatment of obesity. Only a few molecular tools, i. e., radiolabeled and fluorescent ligands, for the investigation of the Y4R were reported. Previously, [Lys(4)]hPP proved to be an appropriate full-length PP analog to prepare a fluorescent ligand by derivatization at the ε-amino group. To preclude oxidation upon long-term storage, we replaced the two methionine residues in [Lys(4)]hPP by norleucine and prepared the corresponding [(3)H]propionylated ([(3)H]12) and cyanine labeled (13) peptides, which were characterized and compared with a set of reference compounds in binding (Y1, Y2, Y4 and Y5 receptors) and functional (luciferase gene reporter, β-arrestin-1, -2) Y4R assays...
March 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28345620/acute-and-chronic-mitochondrial-respiratory-chain-deficiency-differentially-regulate-lysosomal-biogenesis
#5
Lorena Fernández-Mosquera, Cátia V Diogo, King Faisal Yambire, Gabriela L Santos, Marta Luna Sánchez, Paule Bénit, Pierre Rustin, Luis Carlos Lopez, Ira Milosevic, Nuno Raimundo
Mitochondria are key cellular signaling platforms, affecting fundamental processes such as cell proliferation, differentiation and death. However, it remains unclear how mitochondrial signaling affects other organelles, particularly lysosomes. Here, we demonstrate that mitochondrial respiratory chain (RC) impairments elicit a stress signaling pathway that regulates lysosomal biogenesis via the microphtalmia transcription factor family. Interestingly, the effect of mitochondrial stress over lysosomal biogenesis depends on the timeframe of the stress elicited: while RC inhibition with rotenone or uncoupling with CCCP initially triggers lysosomal biogenesis, the effect peaks after few hours and returns to baseline...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345434/effect-of-diabetes-treatment-related-attributes-on-costs-to-type-2-diabetes-patients-in-a-real-world-population
#6
Jie Meng, Roman Casciano, Yi-Chien Lee, Lee Stern, Dmitry Gultyaev, Liyue Tong, Brice Kitio-Dschassi
BACKGROUND: Type 2 diabetes mellitus (T2DM) results in a substantial economic burden on patients, health care systems, and society. Most literature assessing the cost of T2DM focuses on the long-term complications of the disease, the association between glucose control and cost, and patient characteristics resulting in poor and costly outcomes. However, it is likely that attributes specific to diabetes therapy can affect the use of costly resources. OBJECTIVE: To estimate the effect of diabetes treatment-related attributes, such as improved efficacy, adherence, and reduced risk for hypoglycemia, on costs to T2DM patients...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345115/counseling-practices-for-fetal-hypoplastic-left-heart-syndrome
#7
Michael J Walsh, George R Verghese, M Eric Ferguson, Nora F Fino, David J Goldberg, Sonal T Owens, Nelangi Pinto, Sinai C Zyblewski, Michael D Quartermain
While counseling parents of a fetus diagnosed with hypoplastic left heart syndrome (HLHS), pediatric cardiologists play a critical role in shaping a family's expectations for the months and years to come. However, techniques for the most effective counseling practices have not been studied, and significant variation among physicians is likely present. Web-based survey of pediatric cardiologists that perform fetal echocardiography using snowball sampling. 201 physicians responded (61% male, 81% from academic centers, and 95% from the U...
March 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28344999/long-term-engraftment-and-fetal-globin-induction-upon-bcl11a-gene-editing-in-bone-marrow-derived-cd34-hematopoietic-stem-and-progenitor-cells
#8
Kai-Hsin Chang, Sarah E Smith, Timothy Sullivan, Kai Chen, Qianhe Zhou, Jason A West, Mei Liu, Yingchun Liu, Benjamin F Vieira, Chao Sun, Vu P Hong, Mingxuan Zhang, Xiao Yang, Andreas Reik, Fyodor D Urnov, Edward J Rebar, Michael C Holmes, Olivier Danos, Haiyan Jiang, Siyuan Tan
To develop an effective and sustainable cell therapy for sickle cell disease (SCD), we investigated the feasibility of targeted disruption of the BCL11A gene, either within exon 2 or at the GATAA motif in the intronic erythroid-specific enhancer, using zinc finger nucleases in human bone marrow (BM) CD34(+) hematopoietic stem and progenitor cells (HSPCs). Both targeting strategies upregulated fetal globin expression in erythroid cells to levels predicted to inhibit hemoglobin S polymerization. However, complete inactivation of BCL11A resulting from bi-allelic frameshift mutations in BCL11A exon 2 adversely affected erythroid enucleation...
March 17, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28344798/long-term-outcomes-of-botulinum-toxin-in-the-treatment-of-chronic-anal-fissure-5-years-of-follow-up
#9
Sandra Barbeiro, Catarina Atalaia-Martins, Pedro Marcos, Cláudia Gonçalves, Manuela Canhoto, Bruno Arroja, Filipe Silva, Isabel Cotrim, Liliana Eliseu, Antonieta Santos, Helena Vasconcelos
BACKGROUND: Chronic anal fissure is a frequent and disabling disease, often affecting young adults. Botulinum toxin and lateral internal sphincterotomy are the main therapeutic options for refractory cases. Botulinum toxin is minimally invasive and safer compared with surgery, which carries a difficult post-operative recovery and fecal incontinence risk. The long-term efficacy of Botulinum toxin is not well known. OBJECTIVE: The aim of this study was to evaluate the long-term efficacy and safety of Botulinum toxin in the treatment of chronic anal fissure...
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28344332/molecular-and-functional-heterogeneity-of-early-postnatal-porcine-satellite-cell-populations-is-associated-with-bioenergetic-profile
#10
Claudia Miersch, Katja Stange, Silvio Hering, Martin Kolisek, Torsten Viergutz, Monika Röntgen
During postnatal development, hyperplastic and hypertrophic processes of skeletal muscle growth depend on the activation, proliferation, differentiation, and fusion of satellite cells (SC). Therefore, molecular and functional SC heterogeneity is an important component of muscle plasticity and will greatly affect long-term growth performance and muscle health. However, its regulation by cell intrinsic and extrinsic factors is far from clear. In particular, there is only minor information on the early postnatal period which is critical for muscle maturation and the establishment of adult SC pools...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344184/arteriovenous-hybrid-graft-with-outflow-in-the-proximal-axillary-vein
#11
Allen G Murga, Jason Chiriano, Sharon C Kiang, Sheela Patel, Christian Bianchi, Ahmed M Abou-Zamzam, Theodore H Teruya
INTRODUCTION: The patency of long-term hemodialysis access in end-stage renal disease (ESRD) patients remains a significant challenge. Often these patients are affected with limited venous outflow options, requiring limb abandonment and creation of new access in the contralateral arm. Vascular surgeons are familiar with the exposure of the proximal axillary artery via an infraclavicular incision. The axillary vein is easily exposed through this technique. The use of the hybrid Gore graft can make the venous anastomosis easier...
March 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28344022/aga-institute-clinical-practice-update-care-of-patients-who-have-achieved-a-sustained-virologic-response-svr-following-antiviral-therapy-for-chronic-hepatitis-c-infection
#12
REVIEW
Ira M Jacobson, Joseph K Lim, Michael W Fried
Chronic hepatitis C virus (HCV) infection is well-recognized as a common blood borne infection with global public health impact, affecting 3 to 5 million persons in the U.S. and over 170 million persons worldwide. Chronic HCV infection is associated with significant morbidity and mortality due to complications of liver cirrhosis and hepatocellular carcinoma (HCC). Current therapies with all-oral directly acting antiviral agents (DAAs) are associated with high rates of sustained virologic response (SVR), generally exceeding 90%...
March 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28343884/short-term-desensitization-of-fast-escape-behavior-associated-with-suppression-of-mauthner-cell-activity-in-larval-zebrafish
#13
Megumi Takahashi, Maya Inoue, Masashi Tanimoto, Tsunehiko Kohashi, Yoichi Oda
Escape is among the simplest animal behaviors employed to study the neural mechanisms underlying learning. Teleost fishes exhibit behavioral learning of fast escape initiated with a C-shaped body bend (C-start). C-starts are subdivided into short-latency (SLC) and long-latency (LLC) types in larval zebrafish. Whether these two can be separately modified, and the neural correlates of this modification, however, remains undetermined. We thus performed Ca(2+) imaging of Mauthner (M-) cells, a pair of giant hindbrain neurons constituting a core element of SLC circuit, during behavioral learning in larval zebrafish...
March 23, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28343666/removable-partial-dentures-the-clinical-need-for-innovation
#14
REVIEW
Stephen D Campbell, Lyndon Cooper, Helen Craddock, T Paul Hyde, Brian Nattress, Sue H Pavitt, David W Seymour
STATEMENT OF PROBLEM: The number of partially dentate adults is increasing, and many patients will require replacement of missing teeth. Although current treatment options also include fixed partial dentures and implants, removable partial dentures (RPDs) can have advantages and are widely used in clinical practice. However, a significant need exists to advance materials and fabrication technologies because of the unwanted health consequences associated with current RPDs. PURPOSE: The purpose of this review was to assess the current state of and future need for prosthetics such as RPDs for patients with partial edentulism, highlight areas of weakness, and outline possible solutions to issues that affect patient satisfaction and the use of RPDs...
March 23, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28343043/clonal-integration-increases-tolerance-of-a-phalanx-clonal-plant-to-defoliation
#15
Pu Wang, Huan Li, Xiao-Yu Pang, Ao Wang, Bi-Cheng Dong, Jing-Pin Lei, Fei-Hai Yu, Mai-He Li
Defoliation by herbivores commonly imposes negative effects on plants, and physiological integration (resource sharing) can enhance the ability of guerilla clonal plants to tolerate stresses. Here we examined whether physiological integration can increase the ability of phalanx clonal plants to withstand defoliation. On a high mountain grassland in southwestern China, we subjected the phalanx clonal plant Iris delavayi within 10cm×10cm plots to three levels of defoliation intensity, i.e., control (no defoliation), moderate (50% shoot removal to simulate moderate herbivory) and heavy defoliation (100% shoot removal to simulate heavy herbivory), and kept rhizomes at the plot edges connected (allowing physiological integration) or disconnected (preventing integration) with intact ramets outside the plots...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28341725/paraneoplastic-endocrine-syndromes
#16
Georgios K Dimitriadis, Anna Angelousi, Martin O Weickert, Harpal S Randeva, Gregory A Kaltsas, Ashley B Grossman
The majority of neoplasms produce symptoms related to mass effects to surrounding tissues and/or through the development of metastases. However, occasionally neoplasms, with or without endocrine differentiation, acquire the ability to secrete a variety of bioactive substances or induce immune cross-reactivity with the normal tissues that can lead to the development of characteristic clinical syndromes. These syndromes are named endocrine paraneoplastic when the specific secretory components (hormones, peptides or cytokines) are unrelated to the anticipated tissue or organ of origin...
March 24, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28341608/the-dual-pathway-model-of-binge-eating-is-there-a-need-for-modification
#17
Marie Sehm, Petra Warschburger
The dual-pathway model proposes that body dissatisfaction might lead to binge eating (BE) through restraint eating and negative affect. Both pathways have been confirmed longitudinally, but there is evidence that the affect-pathway might rather be found in the short-term, whereas other variables might be involved over longer periods. Research suggests that self-esteem represents a key-factor in the etiology of BE in adolescent girls and might serve as a mediator between body dissatisfaction and eating pathology...
March 21, 2017: Appetite
https://www.readbyqxmd.com/read/28341585/the-experiences-of-last-year-student-midwives-with-high-fidelity-perinatal-simulation-training-a-qualitative-descriptive-study
#18
Joeri Vermeulen, Katrien Beeckman, Rivka Turcksin, Lies Van Winkel, Léonardo Gucciardo, Monika Laubach, Wim Peersman, Eva Swinnen
BACKGROUND: Simulation training is a powerful and evidence-based teaching method in healthcare. It allows students to develop essential competences that are often difficult to achieve during internships. High-Fidelity Perinatal Simulation exposes them to real-life scenarios in a safe environment. Although student midwives' experiences need to be considered to make the simulation training work, these have been overlooked so far. AIM: To explore the experiences of last-year student midwives with High-Fidelity Perinatal Simulation training...
March 21, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28341151/mice-heterozygous-for-an-inactivated-allele-of-the-schizophrenia-associated-brd1-gene-display-selective-cognitive-deficits-with-translational-relevance-to-schizophrenia
#19
Per Qvist, Anto P Rajkumar, John P Redrobe, Mette Nyegaard, Jane H Christensen, Ole Mors, Gregers Wegener, Michael Didriksen, Anders D Børglum
Schizophrenia is a debilitating brain disorder characterized by disturbances of emotion, perception and cognition. Cognitive impairments predict functional outcome in schizophrenia and are detectable even in the prodromal stage of the disorder. However, our understanding of the underlying neurobiology is limited and procognitive treatments remain elusive. We recently demonstrated that mice heterozygous for an inactivated allele of the schizophrenia-associated Brd1 gene (Brd1(+/-) mice) display behaviors reminiscent of schizophrenia, including impaired social cognition and long-term memory...
March 21, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28341094/association-between-exposure-to-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-prior-to-septic-shock-and-acute-kidney-injury
#20
B Suberviola, E Rodrigo, A González-Castro, M Serrano, M Heras, Á Castellanos-Ortega
OBJECTIVE: To evaluate the association between angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) use prior to a septic shock episode and the development, prognosis and long-term recovery from acute kidney injury (AKI). DESIGN: A single-centre, prospective observational study was carried out between September 2005 and August 2010. SCOPE: Patients admitted to the ICU of a third level hospital. PATIENTS: A total of 386 septic shock patients were studied...
January 2017: Medicina Intensiva
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