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https://www.readbyqxmd.com/read/29786817/targeted-cardiopulmonary-resuscitation-training-focused-on-the-family-members-of-high-risk-patients-at-a-regional-medical-center-a-comparison-between-family-members-of-high-risk-and-no-risk-patients
#1
Kap Su Han, Ji Sung Lee, Su Jin Kim, Sung Woo Lee
BACKGROUND: We developed a hospital-based cardiopulmonary resuscitation (CPR) training model focused on the target population (family members of patients with potential risks for cardiac arrest) and compared the outcome of CPR training between target and non-target populations for validity. METHODS: Family members of patients in training were divided into three groups on the basis of patients' diseases, as follows: 1) the cardio-specific (CS) risk group, including family members of patients with cardiac disease at risk of cardiac arrest; 2) the cardiovascular (CV) risk group, including family members of patients with risk factors for cardiovascular disease; and 3) the no-risk group...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786073/integrin-%C3%AE-6%C3%AE-4-src-akt-signaling-induces-cellular-senescence-by-counteracting-apoptosis-in-irradiated-tumor-cells-and-tissues
#2
Seung Hee Jung, Minyoung Lee, Hyun A Park, Hyung Chul Lee, Donghee Kang, Hyun Jung Hwang, Chanho Park, Dong-Min Yu, Yu Ri Jung, Mi-Na Hong, Yong-Nyun Kim, Heon Joo Park, Young-Gyu Ko, Jae-Seon Lee
Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have demonstrated that cellular senescence plays a crucial role in the regression of tumors exposed to ionizing radiation (IR), but the underlying mechanism remains unknown. Here we show that the activation of integrin β4 is essential for IR-induced cellular senescence. IR treatment results in the phosphorylation of integrin β4 at tyrosine residue 1510, leading to activation of the integrin α6β4-Src-AKT signaling pathway...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29783851/the-death-debate-penumbra-conundrum
#3
Robert F Johnson
Determination and declaration of death by neurologic criteria, brain death, is an established and legally accepted clinical practice with profound implications. Concerns regarding the accuracy of this diagnosis raise important clinical, ethical, and legal issues. A recent magazine article highlights these concerns by describing a poignant example of a patient meeting accepted clinical and ancillary testing criteria for brain death in the setting of post cardiac arrest hypoxic ischemic encephalopathy (CA-HIE)...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29783184/postoperative-outcomes-in-patients-with-a-do-not-resuscitate-dnr-order-undergoing-elective-procedures
#4
Ethan Y Brovman, Elisa C Walsh, Brittany N Burton, Christine E Kuo, Charlotta Lindvall, Rodney A Gabriel, Richard D Urman
STUDY OBJECTIVE: Do-not-resuscitate (DNR) status has been shown to be an independent risk factor for mortality in the post-operative period. Patients with DNR orders often undergo elective surgeries to alleviate symptoms and improve quality of life, but there are limited data on outcomes for informed decision making. DESIGN: Retrospective cohort study. SETTING: A multi-institutional setting including operating room, postoperative recovery area, inpatient wards, and the intensive care unit...
May 18, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29783095/initiating-buprenorphine-treatment-prior-to-versus-after-release-from-prison-arrest-outcomes
#5
Michael S Gordon, Thomas R Blue, Kathryn Couvillion, Robert P Schwartz, Kevin E O'Grady, Terrence T Fitzgerald, Frank J Vocci
BACKGROUND: This secondary analysis of a randomized trial examines the association between initiation of buprenorphine treatment prior to, versus post-release, and rearrests during the 12-months following release. METHODS: Official rearrest data (N = 199) for the 12-months post-release were examined. Four outcomes were measured: (1) rearrested (yes/no), (2) time to rearrest, (3) number of rearrests, and (4) severity of charges (less severe vs. severe). RESULTS: A minority (43...
May 12, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29781687/assessment-of-nurses-cardiopulmonary-resuscitation-knowledge-and-skills-within-three-district-hospitals-in-botswana
#6
Lakshmi Rajeswaran, Megan Cox, Stoffel Moeng, Billy M Tsima
BACKGROUND:  Nurses are usually the first to identify the need for and initiate cardiopulmonary resuscitation (CPR) on patients with cardiopulmonary arrest in the hospital setting. Cardiopulmonary resuscitation has been shown to reduce in-hospital deaths when received from adequately trained health care professionals. AIM:  We aimed to investigate nurses' retention of CPR knowledge and skills at district hospitals in Botswana. METHODS:  A quantitative, quasi-experimental study was conducted at three hospitals in Botswana...
April 12, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29777769/a-combined-approach-for-the-early-recognition-of-acute-kidney-injury-after-adult-cardiac-surgery
#7
Cédrick Zaouter, Julien Potvin, Marie-Lise Bats, Marie-Christine Beauvieux, Alain Remy, Alexandre Ouattara
BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication. The current criteria to detect CSA-AKI rise only when organic dysfunction has occurred. The Doppler Renal Resistive Index (RRI) and the urinary G1 cell cycle arrest proteins (TIMP-2 and IGFBP7) have been advocated to predict CSA-AKI at an early stage after cardiac surgery. The primary objective was to determine the predictive value of these new markers to detect CSA-AKI after elective heart surgery in patients at risk to develop AKI...
May 16, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29769006/role-of-cardiac-catheterization-lab-post-resuscitation-in-patients-with-st-elevation-myocardial-infarction
#8
Sridhar Reddy, Kwan S Lee, Karl Kern, Kapildeo Lotun
BACKGROUND: Cardiac arrest remains a common and lethal condition associated with high morbidity and mortality. Even with improving survival rates, the successfully resuscitated post cardiac arrest patient is also at risk for poor neurological outcomes, functional status and long- term survival if not managed appropriately. Given that acute coronary occlusion has been found to be the leading cause of cardiac arrest, long-term prognosis is good in selected patients after successful out-of-hospital resuscitation and ST elevation myocardial infarction who are taken for immediate coronary angiography, treated with primary percutaneous coronary intervention and hypothermia when indicated...
May 16, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29763810/forensic-drug-intelligence-and-the-rise-of-cryptomarkets-part-ii-combination-of-data-from-the-physical-and-virtual-markets
#9
Marie Morelato, Julian Broséus, Adrian De Grazia, Mark Tahtouh, Pierre Esseiva, Claude Roux
Technology provides new ways to access customers and suppliers while enhancing the security of off-line criminal activity. Since the first cryptomarket, Silk Road, in 2011, cryptomarkets have transformed the traditional drug sale by facilitating the creation of a global network of vendors and buyers. Due to the fragmented nature of traces that result from illegal activities, combining the results of concurrent processes based on traces of different nature should provide supplementary benefit to understand the drug market...
May 8, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29762071/vla-4-mediated-adhesion-of-melanoma-cells-on-the-blood-brain-barrier-is-the-critical-cue-for-melanoma-cell-intercalation-and-barrier-disruption
#10
Ana B García-Martín, Pascale Zwicky, Thomas Gruber, Christoph Matti, Federica Moalli, Jens V Stein, David Francisco, Gaby Enzmann, Mitchell P Levesque, Ekkehard Hewer, Ruth Lyck
Melanoma is the most aggressive skin cancer in humans. One severe complication is the formation of brain metastasis, which requires extravasation of melanoma cells across the tight blood-brain barrier (BBB). Previously, VLA-4 has been assigned a role for the adhesive interaction of melanoma cells with non-BBB endothelial cells. However, the role of melanoma VLA-4 for breaching the BBB remained unknown. In this study, we used a mouse in vitro BBB model and imaged the shear resistant arrest of melanoma cells on the BBB...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29759300/decreased-contractile-response-of-peripheral-arterioles-to-serotonin-after-cpb-in-patients-with-diabetes
#11
Sharif A Sabe, Jun Feng, Yuhong Liu, Laura A Scrimgeour, Afshin Ehsan, Frank W Sellke
BACKGROUND: Regulation of coronary vasomotor tone by serotonin is significantly changed after cardioplegic arrest and reperfusion. The current study investigates whether cardiopulmonary bypass may also affect peripheral arteriolar response to serotonin in patients with or without diabetes. METHODS: Human peripheral microvessels (90-180 µm diameter) were dissected from harvested skeletal muscle tissues from diabetic and non-diabetic patients before and after cardiopulmonary bypass and cardiac surgery (n = 8/group)...
May 11, 2018: Surgery
https://www.readbyqxmd.com/read/29755185/recidivism-in-a-sample-of-serious-adolescent-offenders
#12
Robert Brame, Edward P Mulvey, Carol A Schubert, Alex R Piquero
Objectives: A broad research literature in criminology documents key aspects of how criminal offending develops and changes over the life span. We contribute to this literature by showcasing methods that are useful for studying medium-term patterns of subsequent criminal justice system involvement among a sample of serious adolescent offenders making the transition to early adulthood. Methods: Our approach relies on 7 years of post-enrollment follow-up from the Pathways to Desistance Study...
March 2018: Journal of Quantitative Criminology
https://www.readbyqxmd.com/read/29754265/resveratrol-analogue-e-n-2-4-methoxystyryl-phenyl-furan-2-carboxamide-induces-g-2-m-cell-cycle-arrest-through-the-activation-of-p53-p21-cip1-waf1-in-human-colorectal-hct116-cells
#13
Foo Kit Cheah, Kok Hoong Leong, Noel Francis Thomas, Hui Kee Chin, Azhar Ariffin, Khalijah Awang
Resveratrol, a naturally occurring polyphenolic antioxidant, is a potential chemoprophylactic agent for various cancers, including colorectal cancer. Although emerging evidence continually suggests that a number of resveratrol derivatives may be better cancer chemopreventive candidates than resveratrol, studies on the mechanism of action of these derivatives are limited. This is the first study which investigates the mechanism underlying the cytotoxic effect of a synthesized resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide (CS) on colorectal cancer...
May 12, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29752776/influence-of-prehospital-airway-management-on-neurological-outcome-in-patients-transferred-to-a-heart-attack-centre-following-out-of-hospital-cardiac-arrest
#14
Timothy Edwards, Julia Williams, Michaela Cottee
OBJECTIVE: To describe the association between prehospital airway management and neurological outcomes in patients transferred by the ambulance service directly to a heart attack centre (HAC) post-return of spontaneous circulation (ROSC). METHODS: A retrospective observational cohort study in which ambulance records were reviewed to determine prehospital airway management strategy and collect physiological and demographic data. HAC notes were obtained to determine in-hospital management and quantify neurological outcome via the cerebral performance category (CPC) scale...
May 11, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29751827/timp-2-igfbp7-predicts-acute-kidney-injury-in-out-of-hospital-cardiac-arrest-survivors
#15
Christoph Adler, Tobias Heller, Felix Schregel, Henning Hagmann, Martin Hellmich, Joana Adler, Hannes Reuter
BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiopulmonary resuscitation (CPR) and predicts in-hospital mortality. To which extent post-resuscitation disease or the initial event of cardiac arrest and the duration of insufficient cardiac output triggers AKI is challenging to discriminate. Knowledge on molecular mediators of AKI is scarce. Early identification of patients at high risk of AKI is hampered by the low sensitivity of the established tests in clinical routine practice...
May 12, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29749536/biib021-an-hsp90-inhibitor-a-promising-therapeutic-strategy-for-blood-malignancies-review
#16
Wei He, Huixian Hu
Heat shock proteins (HSPs) are molecular chaperones that are consistently increased to help cells survive under conditions of stress. As a member of the Hsps, Hsp90 is involved in protein post‑translational maturation and disposition. This protein is ubiquitously expressed in normal cells. However, in cancer cells and particularly in hematological malignancies, Hsp90 is unexpectedly abundant to maintain levels of proteins vital for cancer pathology. Hsp90 inhibitors can target the ATP domain of Hsp90 and prohibit its exchange of ADP for ATP, leading to the degradation of client proteins and disruption of signaling cascades...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29748701/patient-characteristics-and-emergency-department-factors-associated-with-survival-after-sudden-cardiac-arrest-in-children-and-young-adults-a-cross-sectional-analysis-of-a-nationally-representative-sample-2006-2013
#17
Rie Sakai-Bizmark, Scott M I Friedlander, Emily H Marr, Laurie A Mena, Ismael Corral, Ruey-Kang R Chang
The purpose of the study is to examine (1) nationally representative incidence rates of Emergency Department (ED) visits due to sudden cardiac arrest (SCA) in pediatric and young adult populations, (2) basic characteristics of the ED visits with SCA, and (3) patient and hospital factors associated with survival after SCA. We used the Nationwide Emergency Department Sample from 2006 to 2013. ICD-9-CM diagnostic codes identified ED visits due to SCA for patients ≤ 30 years old. Outcomes included yearly incidence of ED visits for SCA, and survival to hospital discharge...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29746987/age-and-benefit-of-early-coronary-angiography-after-out-of-hospital-cardiac-arrest-in-patients-presenting-with-shockable-rhythm-insights-from-the-sudden-death-expertise-center-registry
#18
Nadia Aissaoui, Wulfran Bougouin, Florence Dumas, Franckie Beganton, Richard Chocron, Olivier Varenne, Christian Spaulding, Nicole Karam, Gilles Montalescot, Pierre Aubry, Georges Sideris, Eloi Marijon, Xavier Jouven, Alain Cariou
BACKGROUND: Little is known about the association between provision of post-resuscitation care and prognosis of out-of-hospital cardiac arrest(OHCA) in elderly patients. Previous studies have suggested futility after 65 years of age. OBJECTIVES: We aimed to evaluate the association of early coronary angiogram(CAG) followed if necessary by percutaneous coronary intervention(PCI), with favorable outcome after OHCA among elderly patients, compared to younger patients...
May 7, 2018: Resuscitation
https://www.readbyqxmd.com/read/29744657/transcatheter-intervention-of-coronary-obstructions-in-infants-children-and-young-adults
#19
Ryan Callahan, James E Lock, Pinak B Shah, Audrey C Marshall
This study assesses the characteristics of coronary obstructions that underwent transcatheter intervention in a pediatric catheterization laboratory, the procedural details, and patient outcomes. Acute cardiac failure due to coronary obstructions in children is rare. The role of catheter based intervention is largely unreported. Single center retrospective review between January 2000 and December 2016. Thirty-three patients (median age 2y/o [0-38], weighing 9.6 kg [2.2-91]) underwent 39 transcatheter interventions on 39 lesions, mainly left main coronary (16/39; 39%) and right coronary (9/39; 23%) arteries...
May 9, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29740777/severe-metabolic-acidosis-after-out-of-hospital-cardiac-arrest-risk-factors-and-association-with-outcome
#20
Matthieu Jamme, Omar Ben Hadj Salem, Lucie Guillemet, Pierre Dupland, Wulfran Bougouin, Julien Charpentier, Jean-Paul Mira, Frédéric Pène, Florence Dumas, Alain Cariou, Guillaume Geri
BACKGROUND: Metabolic acidosis is frequently observed as a consequence of global ischemia-reperfusion after out-of-hospital cardiac arrest (OHCA). We aimed to identify risk factors and assess the impact of metabolic acidosis on outcome after OHCA. METHODS: We included all consecutive OHCA patients admitted between 2007 and 2012. Using admission data, metabolic acidosis was defined by a positive base deficit and was categorized by quartiles. Main outcome was survival at ICU discharge...
May 8, 2018: Annals of Intensive Care
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