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https://www.readbyqxmd.com/read/29470701/preservation-of-gonadal-function-in-women-undergoing-chemotherapy-a-systematic-review-and-meta-analysis-of-the-potential-role-for-gonadotropin-releasing-hormone-agonists
#1
REVIEW
Lisa C Hickman, Natalia C Llarena, Lindsey N Valentine, Xiaobo Liu, Tommaso Falcone
PURPOSE: To evaluate the available randomized controlled trials (RCTs) in the literature investigating the use of gonadotropin-releasing hormone agonist (GnRHa) co-treatment for ovarian preservation in women receiving chemotherapy. METHODS: A systematic review of the literature was performed from 1960 through 2017 to identify relevant RCTs. Included patients had lymphoma, ovarian cancer, or breast cancer. The primary outcome was the proportion of women who retained ovarian function after chemotherapy...
February 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29466689/the-protective-effects-of-gonadotropin-releasing-hormone-agonist-on-ovarian-functions-in-breast-cancer-patients-receiving-chemotherapy
#2
Chen Wang, Xing-Fei Yu
In recent decades, the incidence rate of breast cancer has increased dramatically worldwide and has become one of the most prevalent cancers in women. According to the global data provided by the WHO, there were more than 1.7 million new cases of breast cancer in 2012, accounting for 25% of all reported cancer cases and 15% of all reported deaths among females. To most young patients, especially those younger than 40 years of age, chemotherapy should be taken into consideration as a treatment modality, even if the tumor size is small or without lymphatic metastasis...
January 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29462389/neoplasia-and-precursor-lesions-of-the-female-genital-tract-in-ibd-epidemiology-role-of-immunosuppressants-and-clinical-implications
#3
Hanna M J L Hazenberg, Nanne K H de Boer, Chris J J Mulder, Stijn H Mom, Ad A van Bodegraven, Greetje J Tack Md PhD
In this review the risk of breast, ovarian, and endometrial cancer and cervical and vulvovaginal (pre)malignant abnormalities in patients with inflammatory bowel disease (IBD) with or without immune suppressive treatment will be discussed. So far, this has not been studied thoroughly and large studies taking into account diverse potential confounding factors are lacking. IBD per se has not been associated with development of cervical cancer, yet patients with Crohn's disease who smoke, have a younger age at diagnosis or who use(d) thiopurines might be more at risk...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29460478/routine-germline-brca1-and-brca2-testing-in-ovarian-carcinoma-patients-analysis-of-the-scottish-real-life-experience
#4
Kelly Rust, Pavlina Spiliopoulou, Chee Yuan Tang, Christine Bell, Diane Stirling, Tze Hui Fifi Phang, Rosemarie Davidson, Melanie Mackean, Fiona Nussey, Ros Glasspool, Nick Reed, Azmat Sadozye, Mary Porteous, Trevor McGoldrick, Michelle Ferguson, Zofia Miedzybrodzka, Iain A McNeish, Charlie Gourley
OBJECTIVE: To determine the rate of germline BRCA1 and BRCA2 mutations in Scottish ovarian cancer patients before and after a change in testing policy. DESIGN: Retrospective cohort study. SETTING: Four cancer/genetics centres in Scotland. POPULATION: Ovarian cancer patients undergoing germline BRCA1 and BRCA2 (gBRCA1/2) gene sequencing before 2013 ('old criteria'; selection based solely on family history), after 2013 ('new criteria'; sequencing offered to newly presenting non-mucinous ovarian cancer patients) and the 'prevalent population' (who presented before 2013, were not eligible for sequencing under the old criteria but were sequenced under the new criteria)...
February 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29458907/surgical-and-survival-outcomes-of-laparoscopic-staging-surgery-for-patients-with-stage-i-ovarian-cancer
#5
Chyi-Long Lee, Soshi Kusunoki, Chen-Yin Huang, Kai-Yun Wu, Pei-Shan Lee, Kuan-Gen Huang
OBJECTIVE: To assess the feasibility and survival outcomes of laparoscopic staging for patients with stage I ovarian cancer. MATERIALS AND METHODS: Consecutive patients who underwent laparoscopic staging surgery for stage I ovarian cancer from January 2002 to December 2014 were evaluated retrospectively by chart review. RESULTS: Twenty-four patients with mean age 43.9 ± 9.9 years and mean body mass index 24.0 ± 3.8 kg/m2 were included, in which 12 (50%) patients were in stage IA and 12 (50%) in stage IC...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29456806/women-with-hereditary-breast-cancer-predispositions-should-avoid-using-their-smartphones-tablets-and-laptops-at-night
#6
EDITORIAL
Seyed Ali Reza Mortazavi, Seyed Mohammad Javad Mortazavi
Breast cancer is the most common malignancy among women, both in the developed and developing countries. Women with mutations in the BRCA1 and BRCA2 genes have an increased risk of breast and ovarian cancers. Recent studies show that short-wavelength visible light disturb the secretion of melatonin and causes circadian rhythm disruption. We have previously studied the health effects of exposure to different levels of radiofrequency electromagnetic fields (RF-EMFs) such as mobile phones, mobile base stations, mobile phone jammers, laptop computers, and radars...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456620/endometriosis-and-endometriosis-associated-cancers-new-insights-into-the-molecular-mechanisms-of-ovarian-cancer-development
#7
REVIEW
Amy Dawson, Marta Llauradó Fernandez, Michael Anglesio, Paul J Yong, Mark S Carey
Endometriosis is a fascinating disease that we strive to better understand. Molecular techniques are shedding new light on many important aspects of this disease: from pathogenesis to the recognition of distinct disease variants like deep infiltrating endometriosis. The observation that endometriosis is a cancer precursor has now been strengthened with the knowledge that mutations that are present in endometriosis-associated cancers can be found in adjacent endometriosis lesions. Recent genomic studies, placed in context, suggest that deep infiltrating endometriosis may represent a benign neoplasm that invades locally but rarely metastasises...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29450531/screening-for-ovarian-cancer-us-preventive-services-task-force-recommendation-statement
#8
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: With approximately 14 000 deaths per year, ovarian cancer is the fifth most common cause of cancer death among US women and the leading cause of death from gynecologic cancer. More than 95% of ovarian cancer deaths occur among women 45 years and older. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on screening for ovarian cancer. Evidence Review: The USPSTF reviewed the evidence on the benefits and harms of screening for ovarian cancer in asymptomatic women not known to be at high risk for ovarian cancer (ie, high risk includes women with certain hereditary cancer syndromes that increase their risk for ovarian cancer)...
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29443777/oral-leukoplakia-a-precancerous-lesion-of-squamous-cell-carcinoma-in-patients-with-long-term-pegylated-liposomal-doxorubicin-treatment
#9
Hidetaka Nomura, Kimihiko Sakamoto, Takeru Sugihara, Shuhei Okamoto, Yoichi Aoki, Terumi Tanigawa, Maki Matoda, Kohei Omatsu, Hiroyuki Kanao, Kazuyoshi Kato, Kuniko Utsugi, Yuko Sugiyama, Nobuhiro Takeshima
Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29435699/psychosocial-benefits-of-fertility-preservation-for-young-cancer-patients
#10
Juliana Assi, Juliana Santos, Tatiana Bonetti, Paulo C Serafini, Eduardo L A Motta, Mauricio Barbour Chehin
PURPOSE: The risk of ovarian failure after radiotherapy and/or chemotherapy is a concern among oncologic women. There is no doubt regarding the psycho-emotional benefits of fertility preservation (FP) after a cancer diagnosis because concerns about biological conception are a source of anxiety and can even affect the patient's cancer recovery. The aim of this study was to evaluate oncology patients' feelings, concerns, and life quality impacts related to FP. METHODS: This qualitative cross-sectional study was based on a questionnaire administered to a selected group of women diagnosed with cancer who underwent FP...
February 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29433539/prognostic-impact-of-presumed-breast-or-ovarian-cancer-among-patients-with-unfavorable-subset-cancer-of-unknown-primary-site
#11
Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara, Kenji Tamura
BACKGROUND: The clinical utility and prognostic impact of presumed primary breast or ovarian cancer among patients with an unfavorable subset of cancer of unknown primary site (CUP) remains unclear. We aimed to evaluate the clinical relevance of the presumed primary site of CUP and the clinical outcome of site-specific therapy based on such presumptions. METHODS: Patients referred to our center who were diagnosed with unfavorable-subset CUP and treated between April 2007 and March 2015 were enrolled in this study...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29433453/male-brca-mutation-carriers-clinical-characteristics-and-cancer-spectrum
#12
Mohammed Ibrahim, Siddhartha Yadav, Foluso Ogunleye, Dana Zakalik
BACKGROUND: Mutations in BRCA1 and BRCA2 (BRCA1/2) genes are associated with an increased risk of breast and ovarian cancers in women. The cancer characteristics of men with BRCA1/2 mutations are less well studied. This study describes the unique cancer characteristics of male BRCA1/2 mutation carriers at our institution. METHODS: We performed a retrospective chart review on male patients who were seen between January 2004 and December 2014 and tested positive for a BRCA1/2 mutation...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29428045/genetic-testing-for-hereditary-breast-cancer-the-decision-to-decline
#13
V Brook White, Kendall K Walsh, Kimberly Showers Foss, Lisa Amacker-North, Stacy Lenarcic, Lindsay McNeely, Richard L White
Genetic testing is important for comprehensive cancer care. Commercial analysis of the BRCA1/2 genes has been available since 1996, and testing for hereditary breast and ovarian cancer syndrome is well established. The National Comprehensive Cancer Network (NCCN) guidelines identify individuals for whom BRCA1/2 analysis is appropriate and define management recommendations for mutation carriers. Despite recommendations, not all who meet NCCN criteria undergo genetic testing. We assess the frequency that individuals meeting NCCN criteria decline BRCA1/2 analysis, as well as factors that affect the decision-making process...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29425051/carbohydrate-antigen-125-a-promising-tool-for-risk-stratification-in-heart-diseases
#14
Felipe Falcão, Flávio R A de Oliveira, Flávio R A de Oliveira, Maria Cleide F C da Silva, Dário C Sobral Filho
All patients with heart diseases should undergo risk stratification to predict those who are at high risk for short- and long-term adverse outcomes. Carbohydrate antigen 125 (CA125) is a glycoprotein produced by mesothelium that has clinical role in ovarian cancer monitoring. However, as it is not specific for ovarian cells, CA125 could also be used in heart diseases to monitor congestion and inflammation. Pericarditis, atrial fibrillation, heart failure and coronary artery disease are some scenarios in which this biomarker was studied...
February 9, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29418038/imaging-in-gynecological-disease-clinical-and-ultrasound-characteristics-of-endometrioid-ovarian-cancer
#15
F Moro, G Magoga, T Pasciuto, F Mascilini, M C Moruzzi, D Fischerova, L Savelli, S Giunchi, R Mancari, D Franchi, A Czekierdowski, W Froyman, D Verri, E Epstein, V Chiappa, S Guerriero, G F Zannoni, D Timmerman, G Scambia, L Valentin, A C Testa
OBJECTIVE: To describe the clinical and ultrasound characteristics of ovarian pure endometrioid carcinoma. METHODS: This is a retrospective multicenter study. From the International Ovarian Tumor Analysis (IOTA) database we identified 161 patients with a histological diagnosis of pure endometrioid carcinoma, who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016. Another 78 patients with a histological diagnosis of pure endometrioid carcinoma were identified from the databases of the departments of gynecological oncology in the participating centers...
February 8, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29415128/expression-iii-patient%C3%A2-s-expectations-and-preferences-regarding-physician-patient-relationship-and-clinical-management-results-of-the-international-noggo-engot-ov4-gcig-study-in-1-830-ovarian-cancer-patients-from-european-countries
#16
G Oskay-Özcelik, S Alavi, R Richter, M Keller, S C Cecere, G Cormio, F Joly, J E Kurtz, A du Bois, M Maciejewski, M Jedryka, I Vergote, E Van Nieuwenhuysen, A Casado, C Mendiola, P Achimas-Cadariu, C Vlad, D Reimer, A G Zeimet, M Friedlander, J Sehouli
Backround: The primary aim of this study was to investigate information needs and treatment preferences of patients with ovarian cancer, focusing especially on physician-patient relationship and treatment. Patients and methods: A questionnaire was developed based on the experiences of the national German survey Expression II, and was provided to patients with ovarian cancer either at initial diagnosis or with recurrent disease via Internet (online-version) or as print-out-version...
February 5, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29404823/-second-class-status-insight-into-communication-patterns-and-common-concerns-among-men-with-hereditary-breast-and-ovarian-cancer-syndrome
#17
Alexandra Suttman, Robert Pilarski, Doreen M Agnese, Leigha Senter
Hereditary breast and ovarian cancer syndrome (HBOC) is a cancer predisposition syndrome that affects both men and women, with more significant cancer risk elevations in women. Dissemination patterns regarding familial genetic risk information among females with HBOC are fairly well defined, but knowledge about how males share this information is limited. We interviewed 21 people primarily Ashkenazi Jewish men who were accrued via listserv email through Facing Our Risk of Cancer Empowered (FORCE). Interviews focused on family cancer history, experiences with cancer and genetic testing, motivations to pursue genetic testing and subsequently disclose genetic test results, information-sharing patterns, health care provider response, and participants' emotional support systems...
February 5, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29402700/chromatin-organisation-and-cancer-prognosis-a-pan-cancer-study
#18
Andreas Kleppe, Fritz Albregtsen, Ljiljana Vlatkovic, Manohar Pradhan, Birgitte Nielsen, Tarjei S Hveem, Hanne A Askautrud, Gunnar B Kristensen, Arild Nesbakken, Jone Trovik, Håkon Wæhre, Ian Tomlinson, Neil A Shepherd, Marco Novelli, David J Kerr, Håvard E Danielsen
BACKGROUND: Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the chromatin component of tumour cell nuclei using image texture analysis. As yet, the methodology has not been sufficiently validated to permit its clinical application. We aimed to define and validate a novel prognostic biomarker for the automatic detection of heterogeneous chromatin organisation...
February 2, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29402500/increasing-genetic-counseling-referral-rates-through-bundled-interventions-after-ovarian-cancer-diagnosis
#19
Casey L Swanson, Amanika Kumar, Joy M Maharaj, Jennifer L Kemppainen, Brittany C Thomas, Megan R Weinhold, Kristine M Slaby, Kristin C Mara, Myra J Wick, Jamie N Bakkum-Gamez
OBJECTIVE: To increase genetic counseling referrals for patients with newly diagnosed epithelial ovarian cancer (EOC). METHODS: A practice-gap analysis was performed after measuring baseline genetic counseling referral rates to identify barriers to referral from the multidisciplinary single institution EOC care group. A Genetics Referral Toolkit consisting of a referral template, a genetic risk checklist, family history worksheet and provider and patient awareness was developed to address identified gaps with the goal of increasing referral rates...
February 3, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29400023/diagnostic-value-of-integrated-%C3%A2-%C3%A2-f-fluoro-2-deoxyglucose-positron-emission-tomography-computed-tomography-in-recurrent-epithelial-ovarian-cancer-accuracy-of-patient-selection-for-secondary-cytoreduction-in-134-patients
#20
Young Jae Lee, Yong Man Kim, Phill Seung Jung, Jong Jin Lee, Jeong Kon Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: The aim of this study was to evaluate the diagnostic value of integrated ¹⁸F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) for suspected recurrence of epithelial ovarian cancer (EOC) with non-disseminated lesions. METHODS: We retrospectively reviewed the medical records of recurrent EOC patients who underwent secondary cytoreduction from January 2000 to December 2013. A total of 134 patients underwent secondary cytoreduction after imaging with either ¹⁸F-FDG-PET/CT or contrast-enhanced computed tomography (CECT)...
February 1, 2018: Journal of Gynecologic Oncology
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