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https://www.readbyqxmd.com/read/28920049/effect-of-selenium-on-stress-response-in-coronary-artery-bypass-graft-surgery-a-clinical-trial
#1
Ali Mirmansouri, Vali Imantalab, Ali Mohammadzadeh Jouryabi, Gholamreza Kanani, Bahram Naderi Nabi, Farnoush Farzi, Gelareh Biazar, Samaneh Ghazanfar Tehran, Masoud Tarbiat
BACKGROUND: In spite of significant improvements in surgical and anesthetic techniques, acute stress response to surgery remains a main cause of mortality and morbidity in coronary artery bypass graft (CABG) surgery patients. Therefore, doing research to find safe and effective modalities with more cardio protective properties seems necessary. OBJECTIVES: In this study, we sought to determine whether intravenous injection of 600 μg Selenium (Se) prior to surgery would limit stress response measured by blood sugar...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28883893/the-association-between-alu-hypomethylation-and-severity-of-type-2-diabetes-mellitus
#2
Jirapan Thongsroy, Maturada Patchsung, Apiwat Mutirangura
BACKGROUND: Cellular senescence due to genomic instability is believed to be one of the mechanisms causing health problems in diabetes mellitus (DM). Low methylation levels of Alu elements or Alu hypomethylation, an epigenomic event causing genomic instability, were commonly found in aging people and patients with aging phenotypes, such as osteoporosis. RESULTS: We investigate Alu methylation levels of white blood cells of type 2 DM, pre-DM, and control. The DM group possess the lowest Alu methylation (P < 0...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28868043/metabolomics-profiling-as-a-diagnostic-tool-in-severe-traumatic-brain-injury
#3
REVIEW
Jussi P Posti, Alex M Dickens, Matej Orešič, Tuulia Hyötyläinen, Olli Tenovuo
Traumatic brain injury (TBI) is a complex disease with a multifaceted pathophysiology. Impairment of energy metabolism is a key component of secondary insults. This phenomenon is a consequence of multiple potential mechanisms including diffusion hypoxia, mitochondrial failure, and increased energy needs due to systemic trauma responses, seizures, or spreading depolarization. The degree of disturbance in brain metabolism is affected by treatment interventions and reflected in clinical patient outcome. Hence, monitoring of these secondary events in peripheral blood will provide a window into the pathophysiological course of severe TBI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28832184/type-1-diabetes-at-high-altitude-performance-of-personal-insulin-pumps-and-patient-metabolic-control
#4
Bartłomiej Matejko, Andrzej Gawrecki, Marta Wróbel, Jerzy Hohendorff, Teresa Benbenek-Klupa, Maciej T Malecki, Dorota Zozulińska-Ziółkiewicz, Tomasz Klupa
High-altitude trekking can expose people to extreme environmental conditions, like low temperatures and hypobaric hypoxia. Such extreme conditions make it more difficult for people with type 1 diabetes mellitus (T1DM) to maintain glycemic control. Intensive blood glucose monitoring using either glucose meters or continuous systems is imperative in these cases. In this observational study, we report metabolic control of T1DM patients and the performance of various insulin pumps at high altitude. All 19 patients with T1DM included in this study participated in the final step of the "5000 meters above sugar level" initiative, which involved trekking Damavand Mountain to an altitude of 5670 meters above sea level...
August 23, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28819568/nebivolol-attenuates-neutrophil-lymphocyte-ratio-a-marker-of-subclinical-inflammation-in-hypertensive-patients
#5
Mazhar Hussain, Muhammad Saeed, Muhammad Zafar Majeed Babar, Moazzam Ali Atif, Lubna Akhtar
BACKGROUND: High value of neutrophil lymphocyte ratio (NLR) is a strong independent predictor and biomarker of ongoing vascular inflammation in various cardiovascular disorders. OBJECTIVE: The main focus of the study is to investigate the effect of nebivolol on NLR in mild to moderate hypertensive patients in comparison with metoprolol. In addition, BMI, blood pressure, TLC count, blood sugar, and lipid profile were also assayed before and after treatment. MATERIALS AND METHODS: In this 12-week prospective double-blinded randomized study, 120 patients with mild to moderate hypertension were randomly divided into two groups to prescribed daily dose of tab nebivolol 5-10 mg and metoprolol 50-100 mg, respectively, for 12 weeks...
2017: International Journal of Hypertension
https://www.readbyqxmd.com/read/28818706/diabetes-increases-interleukin-17-levels-in-periapical-hepatic-and-renal-tissues-in-rats
#6
Mariane Maffei Azuma, João Eduardo Gomes-Filho, Annelise Katrine Carrara Prieto, Renata Oliveira Samuel, Valéria Marçal Felix de Lima, Dóris Hissako Sumida, Edilson Ervolino, Luciano Tavares Angelo Cintra
OBJECTIVES: This study aimed to evaluate the association between endodontic infection and diabetes on interleukin-17 levels in periapical, hepatic, and renal tissues of rats. DESIGN: Forty male rats were divided into groups: normoglycemic rats (N), normoglycemic rats with apical periodontitis (N-AP), rats with experimental diabetes (ED), and rats with experimental diabetes and apical periodontitis (ED-AP). Diabetes was induced by intravenous streptozotocin injection, and blood sugar levels were monitored to confirm disease development...
August 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28782747/laparoscopic-surgery-for-solitary-insulinoma-in-the-absence-of-ious
#7
Abhay Narendra Dalvi, Mahadeo Namdeo Garale, Yogesh Prabhakar Takalkar, Sameer Ashok Rege, Pinky Manoharlal Thapar, Lila Anurag, Nalini Samir Shah
BACKGROUND: Insulinomas are the most common pancreatic neuroendocrine neoplasms. In spite of adequate pre-operative localisation, conventional surgical methods rely on intraoperative palpation. Intraoperative ultrasonography (IOUS) is said to aid in accurate localisation, decreases morbidity. Laparoscopic removal of pancreatic endocrine neoplasms is beneficial due to magnification and minimal invasion; however, in the absence of IOUS, error of judgement may lead to conversion to open surgery, thereby relying on 'palpation method' to localise the tumour...
August 1, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28782194/the-preparation-of-hyaluronic-acid-nanoparticles-from-aspicilia-lichens-using-bifido-bacteria-for-help-in-the-treatment-of-diabetes-in-rats-in-vivo
#8
Akbar Esmaeili, Shirin Rajaee
Many common herbs and spices are claimed to have blood sugar lowering properties that make them useful for people with or at high risk of diabetes. The main of compounds of kiwifruit (Actinidia deliciosa), rhubarb (Rheum ribes), membrane inner of egg shell, wool of sheep, human fingernail (unguis), hyaluronic acid produced by the Bifidobacterium, and usnic acid of Aspicilia lichen were extracted by different methods. All compounds of the extract were divided into five groups. We used variables such as pH, different compounds, concentration, number of injections, and blood glucose monitoring in different situations...
August 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28772105/transient-endothelial-dysfunction-induced-by-sugar-sweetened-beverage-consumption-may-be-attenuated-by-a-single-bout-of-aerobic-exercise
#9
Pia Varsamis, Guillaume Walther, Bianca Share, Frances Taylor, Simon Stewart, Christian Lorenzen, Jordan Loader
BACKGROUND: This study assessed whether aerobic exercise would attenuate microvascular endothelial dysfunction induced by commercial sugar-sweetened beverage (SSB) consumption. METHODS: Eleven healthy males participated in this randomized, single-blind crossover study. Cutaneous microvascular endothelial function was assessed using laser speckle contrast imaging coupled with post-occlusive reactive hyperemia before and after a) consumption of water; b) consumption of a commercial SSB; c) 30min of aerobic exercise followed by water consumption; and d) 30 minutes of aerobic exercise followed by SSB consumption...
July 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28753611/the-impact-of-the-quality-of-care-and-other-factors-on-progression-of-chronic-kidney-disease-in-thai-patients-with-type-2-diabetes-mellitus-a-nationwide-cohort-study
#10
Paithoon Sonthon, Supannee Promthet, Siribha Changsirikulchai, Ram Rangsin, Bandit Thinkhamrop, Suthee Rattanamongkolgul, Cameron P Hurst
OBJECTIVE: The present study investigates the impact of quality of care (QoC) and other factors on chronic kidney disease (CKD) stage progression among Type 2 Diabetes Mellitus (T2DM) patients. METHODS: This study employed a retrospective cohort from a nationwide Diabetes and Hypertension study involving 595 Thai hospitals. T2DM patients who were observed at least 2 times in the 3 years follow-up (between 2011-2013) were included in our study. Ordinal logistic mixed effect regression modeling was used to investigate the association between the QoC and other factors with CKD stage progression...
2017: PloS One
https://www.readbyqxmd.com/read/28712186/glycaemic-control-of-type-2-diabetic-patients-during-ramazan-fasting
#11
Uzma Malik, Nasir Mahmood, Khurshid Ahmed Khan, Maliha Hameed, Fawad Ahmed Randhawa, Sadia Salman, Amna Riaz, Khadija Waheed, Aqeela Rasheed
BACKGROUND: Among five main pillars of Islam Fasting is one of the key elements, all healthy adult Muslims have to observe fast from dawn till dusk during the holy month of Ramadan. According to a 2009 demographic study, Islam has 1.57 billion believers, making up 23% of the world population of 6.8 billion, and is growing by 3% per year. EPIDIAR (epidemiology of diabetes and Ramadan) study showed that 43% patients with type 1 and 79% patients with type2 diabetes observe fast during the month of Ramadan...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28700414/evaluation-of-gut-blood-barrier-gbb-dysfunction-in-various-models-of-trauma-haemorrhagic-shock-and-burn-injury
#12
Lisa Wrba, Annette Palmer, Christian Karl Braun, Markus Huber-Lang
Dysfunction of the gut-blood barrier (GBB) plays a pivotal role in various diseases, including trauma, haemorrhagic shock (HS) and burn injury, as well as inflammatory bowel diseases (IBD). Whereas GBB disruption significantly contributes to IBD, the exact extent and consequences of GBB failure and its reliable determination in the clinical course following trauma remain rather unclear. A compromised GBB function seems to contribute to remote organ injury after trauma by generation of inflammatory mediators and biologically active lymph, which in turn augments the inflammatory response...
July 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28681521/changes-of-bladder-m1-3-muscarinic-receptor-expression-in-rats-fed-with-short-term-long-term-high-fat-diets
#13
Chian-Shiung Lin, Tony T-L Wu, Chin-Hong Chang, Juei-Tang Cheng, Yat-Ching Tong
OBJECTIVES: To investigate the effect of high-fat diet (HFD) on bladder M1,3 muscarinic receptor expression and contractile function in the rat. METHODS: Eight-week-old male rats were divided into two groups including one with HFD for 8 weeks (short-term) and the other for 24 weeks (long-term). Each group was compared to age-matched rats fed with normal chow as controls. The body weight, food intake amount and blood biochemistry were monitored. Bladder muscle contractile responses to acetylcholine (0...
July 5, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28678303/a-comparison-of-discovered-regularities-in-blood-glucose-readings-across-two-data-collection-approaches-used-with-a-type-1-diabetic-youth
#14
Victor Lee, Travis Thurston, Chris Thurston
BACKGROUND: Type 1 diabetes requires frequent testing and monitoring of blood glucose levels in order to determine appropriate type and dosage of insulin administration. This can lead to thousands of individual measurements over the course of a lifetime of a single individual, of which very few are retained as part of a permanent record. The third author, aged 9, and his family have maintained several years of written records since his diagnosis with Type 1 diabetes at age 20 months, and have also recently begun to obtain automated records from a continuous glucose monitor...
July 5, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28676054/a-qualitative-analysis-of-the-effectiveness-of-telehealthcare-devices-i-are-they-meeting-the-needs-of-end-users
#15
Natasha C Campling, David G Pitts, Paul V Knight, Richard Aspinall
BACKGROUND: There are many telehealthcare devices currently available ranging from personal alarms, automated pill dispensers and fall detectors through to monitoring devices for blood sugar, blood pressure and heart rate. Many devices remain unused once acquired or shortly after a period of initial use. METHODS: The study used a qualitative design involving focus groups and interviews. End users' opinions of telehealthcare devices were examined through focus groups along with the views of market experts and key supply chain players through telephone interviews to ascertain their views on the devices...
July 4, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28631075/measurement-and-evaluation-of-fetal-fat-layer-in-the-prediction-of-fetal-macrosomia-in-pregnancies-complicated-by-gestational-diabetes
#16
Mohamed Elessawy, Christina Harders, Helmut Kleinwechter, Norbert Demandt, Ghada Abu Sheasha, Nicolai Maass, Ulrich Pecks, Christel Eckmann-Scholz
OBJECTIVES: To explore the predictive power of measuring the abdominal fetal fat layer (FFL) as a soft tissue marker at 31, 34, and 37 weeks' gestation to improve the detection of fetal macrosomia in pregnant women with GDM, in addition to the biometric values with close monitoring of maternal blood sugar level and BMI changes. METHODS: We conducted a prospective observational study at the Department of Obstetrics, University Hospitals, Campus Kiel, Germany, in collaboration with diabetic clinic staff...
June 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28611323/evaluation-of-gingival-blood-as-a-minimally-invasive-screening-tool-for-diabetes-mellitus-among-40-59-year-old-adults-in-dental-clinics-a-cross-sectional-study
#17
Indumathi K Partheeban, Preetha Chaly, Indra Priyadarshni, Mohammed Junaid, J E Nijesh, S Vaishnavi
OBJECTIVE: To evaluate a quick, safe, and minimally invasive method to screen for diabetes using gingival blood with the help of self-monitoring glucometer during periodontal examination. MATERIALS AND METHODS: A hospital-based, cross-sectional comparative study was conducted among 40-59-year-old diabetic and nondiabetic population who had come for their master health examination to a private tertiary care hospital (Global Hospital and Health City) in Chennai. Among them, those who fulfilled the inclusion criteria were selected for the study...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28567298/recurrent-insulinoma-in-a-10-year-old-boy-with-down-s-syndrome
#18
Noman Ahmad, Abdulmonem Mohammed Almutawa, Mohamed Ziyad Abubacker, Hossam Ahmed Elzeftawy, Osama Abdullah Bawazir
An insulinoma is a rare tumour with an incidence of four cases per million per year in adults. The incidence in children is not established. There is limited literature available in children with insulinoma, and only one case is reported in association with Down's syndrome in adults. Insulinoma diagnosis is frequently missed in adults as well as in children. The Whipple triad is the most striking feature although it has limited application in young children. Hypoglycaemia with elevated insulin, C-peptide and absent ketones is highly suggestive of hyperinsulinism...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28561223/antidiabetic-activity-of-extract-and-compounds-from-an-endophytic-fungus-nigrospora-oryzae
#19
Philip F Uzor, Patience O Osadebe, Ngozi J Nwodo
The fungal extract as well as the 3 biosynthetic compounds, (S)-(+)-2-cis-4-trans-abscisic acid (1), , 7'-hydroxy-abscisic acid (2) and 4-des-hydroxyl altersolanol A (3) from the endophytic fungus, Nigrospora oryzae, isolated from Combretum dolichopetalum leaf were investigated for their antidiabetic potential.The antidiabetic activity was determined in alloxan-induced diabetic mice by monitoring their fasting blood sugar for 9 h.The extract and the compounds (1-3) significantly (p<0.001) reduced the fasting blood sugar of the diabetic mice...
May 2017: Drug Research
https://www.readbyqxmd.com/read/28537660/relation-between-blood-pressure-variability-and-early-renal-damage-in-hypertensive-patients
#20
L-H Yin, W-J Yan, Z-X Guo, F-Z Zhou, H-Y Zhang
OBJECTIVE: The objective of the present study was to observe the relation between blood pressure variability (BPV) and early renal damage in hypertensive patients. PATIENTS AND METHODS: A total of 118 hypertensive patients were consecutively selected. General parameters including sex, age, duration, and grade of hypertension, antihypertensive drugs taken, smoking status, blood sugar, blood lipid level, body mass index, indexes of 24-h ambulatory blood pressure monitoring and renal function including cystatin C (CysC), serum creatinine (SCr), angiotensin II (Ang II), microalbuminuria (mALb), and urine creatinine (UCr) were measured...
May 2017: European Review for Medical and Pharmacological Sciences
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