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https://www.readbyqxmd.com/read/27891351/evaluation-of-effect-of-nishamalaki-on-stz-and-hfhf-diet-induced-diabetic-neuropathy-in-wistar-rats
#1
Jayshree Shriram Dawane, Vijaya Anil Pandit, Madhura Shirish Kumar Bhosale, Pallawi Shashank Khatavkar
INTRODUCTION: Diabetic neuropathy is one of the most common complications affecting 50% of diabetic patients. Neuropathic pain is the most difficult types of pain to treat. There is no specific treatment for neuropathy. Nishamalaki (NA), combination of Curcuma longa and Emblica officinalis used to treat Diabetes Mellitus (DM). So, efforts were made to test whether NA is useful in prevention of diabetic neuropathy. AIM: To evaluate the effect of NA on diabetic neuropathy in type 2 diabetic wistar rats...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27882107/effects-of-sitagliptin-as-initial-therapy-in-newly-diagnosed-elderly-type-2-diabetics-a-randomized-controlled-study
#2
Xiaoyan Xiao, Xiaopei Cui, Jianbo Zhang, Zhenxia Han, Yu Xiao, Nan Chen, Baoying Li, Mei Cheng, Haiqing Gao, Kuanxiao Tang
The objective of this study was to investigate the characteristics of blood glycemic excursion, incretins and pancreatic hormone secretion in elderly people with newly diagnosed type 2 diabetes mellitus (T2DM) and to study the effects of sitagliptin on glycemic excursion in these subjects. A total of 129 newly diagnosed T2DM patients were enrolled in the study from March 2012 to August 2013. Clinical data, serum incretin, pancreatic hormone and continuous glucose monitoring data were collected. Among these subjects, elderly patients (NEDM) randomly received metformin combined with sitagliptin phosphate or glimepiride for 24 weeks...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27872709/the-effect-of-sugar-cane-molasses-on-the-immune-and-male-reproductive-systems-using-in-vitro-and-in-vivo-methods
#3
Farzana Rahiman, Edmund John Pool
OBJECTIVES: Sugar cane molasses is a commonly used ingredient in several food products. Contrasting reports suggest that molasses may have potential adverse or beneficial effects on human health. However, little evidence exists that examines the effects of molasses on the different physiological systems. This study investigated the effects of sugar cane molasses on various physiological systems using in vivo and in vitro methods. MATERIALS AND METHODS: Molasses was administered orally to BALB/c, male mice and animals were randomly assigned into either a treatment or control group...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27859863/the-influence-of-very-small-doses-of-alpha-radiation-on-the-stability-of-erythrocytes
#4
Magdalena Kaczmarska, Dominika Żydek, Justyna Wilkłacz-Potoczny, Maria Fornal, Tomasz Grodzicki, Elżbieta Kochowska, Krzysztof Kozak, Łukasz Gocal, Władysław Pohorecki, Krzysztof Matlak, Józef Korecki, Květoslava Burda
Our aim was to study the influence of low doses (0.2-4 μGy) of α radiation on the stability of human erythrocytes isolated from healthy and diabetic erythrocytes. Absorption spectroscopy was used to measure the level of red blood cell (RBC) hemolysis, along with Mössbauer spectroscopy, which is a highly specific method suited to monitoring various hemoglobin forms. States of hemoglobin are sensitive to a homeostatic imbalance in red blood cells. Changes in the membrane skeleton organization of irradiated erythrocytes isolated from healthy donors were studied using atomic force microscopy (AFM)...
November 16, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27855237/insulin-autoimmune-syndrome-a-rare-cause-of-postprandial-hypoglycemia
#5
Pooja Sahni, Nitin Trivedi, Abdulkadir Omer
: A 65-year-old obese Caucasian woman presented with symptomatic postprandial hypoglycemic episodes, resolution of symptoms with carbohydrate intake and significantly elevated anti-insulin antibody levels. She did not have any evidence for the use of oral antidiabetic medications, insulin, herbal substances, performing strenuous exercise or history of bariatric surgery. Fingerstick blood glucose readings revealed blood sugar of 35 mg/dL and 48 mg/dL, when she had these symptoms. Her medical history was significant for morbid obesity, hypothyroidism and gastro esophageal reflux disease...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27825406/relationships-of-blood-pressure-circadian-rhythm-and-brain-br-natriuretic-peptide-with-left-ventricular-hypertrophy-in-br-the-patients-with-primary-hypertension
#6
Hui-Juan Kou, Xin Wang, Deng-Feng Gao, Xin Dong, Jin Wei, Rui Ma
Objective To investigate the relationships of blood pressure circadian rhythm and brain natriuretic peptide (BNP) with left ventricular hypertrophy (LVH) in patients with primary hypertension. Methods Totally 349 patients (74 with LVH and 275 without LVH) with primary hypertension were enrolled in this study.Echocardiography was performed to determine left ventricular mass index (LVMI) using the Devereux formula. The nocturnal blood pressure decline rate,24-hour blood pressure (24 h PP; especially 24 h mean systolic blood pressure,24 h SBP) and blood pressure index (PPI) were determined by 24 h-ambulatory blood pressure monitoring...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27790496/unexplained-persistent-hyperglycaemia-in-a-type-i-diabetes-patient-is-injection-site-lipohypertrophy-the-cause
#7
Ranjana Ajit Sahasrabudhe, Tejas Yashwant Limaye, Vidya Sanjay Gokhale
Type I diabetes patients depend on insulin injections. Proper injection technique is essential for good glycaemic control. Incorrect technique can also lead to local injection site adverse effects, commonest being lipohypertrophy. Hypoglycaemia, by far the most dreaded adverse effect of insulin, receives utmost focus in management of patients on insulin. Lipohypertrophy, on the other hand, is a relatively neglected adverse effect. It is necessary for health care providers to realize that it can also have serious clinical implications...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27790472/arterial-stiffness-and-trace-elements-in-apparently-healthy-population-a-cross-sectional-study
#8
Gangapatnam Subrahmanyam, Rama Mohan Pathapati, Krishnan Ramalingam, Selvam Armugam Indira, Katari Kantha, Bhemasen Soren
INTRODUCTION: Stiffening of arteries is a natural ageing process. Any diseases/disorders or risk factors that escalate oxidative stress, microvascular inflammation and endothelial damage may promote to premature vascular stiffening. Any imbalance in these trace element levels may independently contribute to the changes in the components in the arterial wall and thus, arterial stiffness via one or more mechanisms. AIM: To evaluate the severity of arterial stiffness in apparently healthy population and also to evaluate role of various risk factors and trace elements in the severity of arterial stiffness...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27753929/os-05-04-empagliflozin-exerts-cardio-and-nephro-protective-effects-in-cohen-rosenthal-diabetic-hypertensive-rats
#9
Zaid Abassi, Jonatan Leor, Natalie Landa, Firas Younis, Kenneth Hollander, Eric Mayoux, Lea Rath-Wolfson, Talma Rosenthal
OBJECTIVE: Hypertension and Diabetes commonly coexist and have been implicated in deterioration of kidneys, heart and impairment of pancreas. Empagliflozin (Empa), a selective SGLT2 inhibitor, is a new agent for treatment of diabetes via enhancing glucosuria, independent of insulin resistance. This study evaluates Empa's prophylactic beneficial effect on glomerular, cardiac and pancreatic integrity, in CRDH animals. DESIGN AND METHOD: Cohen Rosenthal Diabetic Hypertensive rats (CRDH) were divided into 3 groups: A- Sugar diet (SD) + Empa, B-Sugar Diet + Veh, C-Regular Chow + Veh (Control)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27746068/targeting-postprandial-blood-sugar-over-fasting-blood-sugar-a-clinic-based-comparative-study
#10
H M M Herath, T P Weerarathna, C L Fonseka, A S Vidanagamage
INTRODUCTION: Recent studies indicate that modulation of post prandial blood sugar (PPBS) plays an important role in the long term glycemic control. Measurement of PPBS is more convenient for patients attending outpatient clinics than fasting blood sugar (FBS) as the former needs only two hours of fasting from the last meal. OBJECTIVE: To assess the value of PPBS monitoring in optimization of long term glycemic control among diabetic patients attending an outpatient clinic...
October 5, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27730074/evaluation-of-accuracy-of-ambulatory-glucose-profile-in-an-outpatient-setting-in-children-with-type-1-diabetes
#11
Anjana Hulse, Suahma Rai, K M Prasanna Kumar
BACKGROUND: In children with type 1 diabetes, intensive diabetes management has been demonstrated to reduce long-term microvascular complications. At present, self-monitoring of blood glucose (SMBG) by patients at home and glycated hemoglobin estimation every 3 months are used to monitor glycemic control in children. Recently, ambulatory glucose profile (AGP) is increasingly being used to study the glycemic patterns in adults. However, accuracy and reliability of AGP in children have not been evaluated yet...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27680758/the-phantom-of-metformin-induced-lactic-acidosis-in-end-stage-renal-disease-patients-time-to-reconsider-with-peritoneal-dialysis-treatment
#12
Abdullah K Al-Hwiesh, Ibrahiem S Abdul-Rahman, Abdul-Salam Noor, Mohammed A Nasr-El-Deen, Abdalla Abdelrahman, Tamer S El-Salamony, Fahd A Al-Muhanna, Khalid M Al-Otaibi, Nehad Al-Audah
♦ Objective: Metformin continues to be the safest and most widely used antidiabetic drug. In spite of its well-known benefits; metformin use in end-stage renal disease (ESRD) patients is still restricted. Little has been reported about the effect of peritoneal dialysis (PD) on metformin clearance and the phantom of lactic acidosis deprives ESRD patients from metformin therapeutic advantages. Peritoneal dialysis is probably a safeguard against lactic acidosis, and it is likely that using this drug would be feasible in this group of patients...
September 28, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27663288/psychological-factors-associated-with-diabetes-self-management-among-adolescents-with-type-1-diabetes-a-systematic-review
#13
Kelly Martinez, Sharon F Frazer, Martin Dempster, Andrea Hamill, Hanora Fleming, Noleen K McCorry
This review aims to synthesise the literature examining the psychosocial variables related to self-management (insulin adherence, non-adherence and administration, blood sugar monitoring, dietary behaviour, exercise behaviour) in adolescents with type 1 diabetes. A systematic search of three electronic databases was carried out and, after the application of eligibility criteria, 21 articles were assessed for quality prior to data extraction. Numerous psychological factors were found to be associated with self-management; however, correlations were typically small to moderate...
September 22, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27643322/os-05-04-empagliflozin-exerts-cardio-and-nephro-protective-effects-in-cohen-rosenthal-diabetic-hypertensive-rats
#14
Zaid Abassi, Jonatan Leor, Natalie Landa, Firas Younis, Kenneth Hollander, Eric Mayoux, Lea Rath-Wolfson, Talma Rosenthal
OBJECTIVE: Hypertension and Diabetes commonly coexist and have been implicated in deterioration of kidneys, heart and impairment of pancreas. Empagliflozin (Empa), a selective SGLT2 inhibitor, is a new agent for treatment of diabetes via enhancing glucosuria, independent of insulin resistance. This study evaluates Empa's prophylactic beneficial effect on glomerular, cardiac and pancreatic integrity, in CRDH animals. DESIGN AND METHOD: Cohen Rosenthal Diabetic Hypertensive rats (CRDH) were divided into 3 groups: A- Sugar diet (SD) + Empa, B-Sugar Diet + Veh, C-Regular Chow + Veh (Control)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27620854/socioeconomic-disparities-in-type-2-diabetes-mellitus-prevalence-and-self-management-behaviors-in-rural-southwest-china
#15
Cai Le, Su Rong, You Dingyun, Cui Wenlong
BACKGROUND: This study examines how socioeconomic factors are associated with prevalence and self-management of diabetes among ethnic minority groups in the rural Yunnan province, which has the most ethnic minority groups per province in southwest China. METHODS: A cross-sectional survey was carried out in 2014 in a rural southwest population consisting of 5532 consenting individuals aged ⩾35years. Information about participants' demographic characteristics, as well as diabetes diagnosis, treatment, and self-management behaviors, were obtained using a standard questionnaire...
August 31, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27603420/lived-experience-of-blood-glucose-self-monitoring-among-pregnant-women-with-gestational-diabetes-mellitus-a-phenomenological-research
#16
Sununta Youngwanichsetha, Sasitorn Phumdoung
AIMS AND OBJECTIVES: To explore and describe lived experience of blood glucose self-monitoring among pregnant Thai women with gestational diabetes mellitus. BACKGROUND: Self- monitoring of blood glucose is an essential practice among pregnant women with diabetes in order to prevent complications in pregnancy and the newborn infant. DESIGN: Phenomenological research was employed to understand lived experiences in glycemic control. METHODS: Thirty participants were approached and interviewed using a semi-structured interview guides...
September 7, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27573296/novel-fungal-fad-glucose-dehydrogenase-derived-from-aspergillus-niger-for-glucose-enzyme-sensor-strips
#17
Koji Sode, Noya Loew, Yosuke Ohnishi, Hayato Tsuruta, Kazushige Mori, Katsuhiro Kojima, Wakako Tsugawa, Jeffrey T LaBelle, David C Klonoff
In this study, a novel fungus FAD dependent glucose dehydrogenase, derived from Aspergillus niger (AnGDH), was characterized. This enzyme's potential for the use as the enzyme for blood glucose monitor enzyme sensor strips was evaluated, especially by investigating the effect of the presence of xylose during glucose measurements. The substrate specificity of AnGDH towards glucose was investigated, and only xylose was found as a competing substrate. The specific catalytic efficiency for xylose compared to glucose was 1...
August 18, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27524256/native-prussian-carp-carassius-gibelio-health-status-biochemical-and-histological-responses-to-treated-wastewaters
#18
Natalija Topić Popović, Ivančica Strunjak-Perović, Josip Barišić, Slavko Kepec, Margita Jadan, Blanka Beer-Ljubić, Vesna Matijatko, Dušan Palić, Goran Klobučar, Sanja Babić, Jasenka Gajdoš Kljusurić, Rozelindra Čož-Rakovac
The aim of this study was to assess the impact of treated wastewaters on native wild Prussian carp inhabiting effluent-receiving waters (ERC) receiving municipal and sugar plant treated wastewaters, further downstream waters (DW), and a detached canal unaffected by the WWTP activities. To that end, general fish health status was determined, including plasma biochemical, haematological, oxidative stress and tissue histopathological indices, over three seasons. The greatest tissue alterations were in fall in ERC during sugar beet processing, as hypertrophy of gill epithelial and interlamellar cells, necrosis and lymphocytic infiltration, hyperplasia and hypertrophy of renal tubules, distention of hepatic sinusoids...
November 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27508759/-op-5d-03-chronic-inflammation-during-pregnancy-influence-the-progression-of-early-sympathetic-mediated-hypertension-in-offspring-arising-from-maternal-obesity
#19
A Samuelsson, J M Pombo, C W Coen, C Mallard, P Gressens, L Poston
OBJECTIVE: Mounting evidence suggests that an overactive immune response during pregnancy may alter the development of the central nervous system in the foetus. An increased concentration of pro-inflammatory cytokines has been demonstrated in amniotic fluid of obese pregnancy. This study investigate if low-chronic inflammation, during brain development may have enduring effects on hypothalamic immune response leading to autonomic disturbances and sympathetic mediated hypertension arising from maternal obesity...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27494246/use-of-in-vitro-assays-to-assess-immunogenicity-risk-of-antibody-based-biotherapeutics
#20
Marisa K Joubert, Meghana Deshpande, Jane Yang, Helen Reynolds, Christine Bryson, Mark Fogg, Matthew P Baker, Jonathan Herskovitz, Theresa J Goletz, Lei Zhou, Michael Moxness, Gregory C Flynn, Linda O Narhi, Vibha Jawa
An In Vitro Comparative Immunogenicity Assessment (IVCIA) assay was evaluated as a tool for predicting the potential relative immunogenicity of biotherapeutic attributes. Peripheral blood mononuclear cells from up to 50 healthy naïve human donors were monitored up to 8 days for T-cell proliferation, the number of IL-2 or IFN-γ secreting cells, and the concentration of a panel of secreted cytokines. The response in the assay to 10 monoclonal antibodies was found to be in agreement with the clinical immunogenicity, suggesting that the assay might be applied to immunogenicity risk assessment of antibody biotherapeutic attributes...
2016: PloS One
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