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https://www.readbyqxmd.com/read/29774672/glucose-sensitive-silicone-hydrogel-contact-lens-toward-tear-glucose-monitoring
#1
Ramachandram Badugu, Edward Albert Reece, Joseph R Lakowicz
Accurate and reliable monitoring of blood glucose is needed for the treatment of diabetes, which has many challenges, including lack of patient compliance. Measuring tear glucose is an alternative to traditional finger-stick tests used to track blood sugar levels, but glucose sensing using tears has yet to be achieved. We report a methodology for possible tear glucose monitoring using glucose-sensitive silicone hydrogel (SiHG) contact lenses, the primary type of lenses available in today's market. Initially, we assessed the interpenetrating polymer network, with nearly pure silicone and water regions, existing in the SiHGs using a polarity-sensitive probe Prodan...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29769806/paediatric-type-1-diabetes-2018-clinical-and-research-insights
#2
Stephen J Zborovski, Farid H Mahmud
The management of children and adolescents with type 1 diabetes continues to progress as clinical and technological innovations enter into practice. Variability in glucose readings can present a significant challenge for care providers, patients and families alike and recent research demonstrates that insulin selection and site-related lipohypertrophy can significantly influence blood glucose levels. New technology aims to improve both glycemic control and quality of life. New insulin analogues have been developed and insulin pumps and continuous glucose monitoring systems continue to evolve toward a fully closed-loop system...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29768642/-rhinocerebral-mucormycosis
#3
Anke Mertens, Christoph Arens, Doreen Barche, Laszlo Scheinpflug, Friedrich Gunther Scholz, Stefan Vielhaber, Cordula Scherlach, Uwe Tröger, Gernot Geginat, Jacqueline Färber
Mucormycosis is a rare but serious type of fungal infection, which can progress rapidly especially in immunsupressed patients.We report about a 47 year old female patient with ptosis on the left eye. The ophthalmological report offered no further pathologic findings. Diabetes mellitus was known and the blood sugar value was very high.A computed tomography of the paranasal sinuses showed a shadow in the ethmoid bone and in an additonally performed MRI-scan, an increase of orbital fat and an extension of the ocular muscle were visible...
May 16, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29761993/-design-and-implementation-of-real-time-continuous-glucose-monitoring-instrument
#4
Yonghong Huang, Hongying Liu, Senfu Tian, Ziru Jia, Zi Wang, Xitian Pi
Real-time continuous glucose monitoring can help diabetics to control blood sugar levels within the normal range. However, in the process of practical monitoring, the output of real-time continuous glucose monitoring system is susceptible to glucose sensor and environment noise, which will influence the measurement accuracy of the system. Aiming at this problem, a dual-calibration algorithm for the moving-window double-layer filtering algorithm combined with real-time self-compensation calibration algorithm is proposed in this paper, which can realize the signal drift compensation for current data...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29682580/access-to-hemoglobin-a1c-in-rural-africa-a-difficult-reality-with-severe-consequences
#5
REVIEW
Paul H Park, Sonak D Pastakia
Sub-Saharan Africa (SSA) continues to have the highest diabetes-related mortality rate in the world. While there exists a multitude of health system barriers driving poor diabetes control, rural facilities particularly in SSA lack access to proper monitoring of glucose and other key biologic tests. At best, most of these diabetes patients receive random blood sugar readings only on the day of their clinic visit. This approach has very limited clinical value in determining dosage adjustments for narrow therapeutic index medications such as insulin...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29580854/metabolomics-based-evidence-of-the-hypoglycemic-effect-of-ge-gen-jiao-tai-wan-in-type-2-diabetic-rats-via-uhplc-qtof-ms-analysis
#6
Wenbo Wang, Linlin Zhao, Zhenyu He, Ning Wu, Qiuxia Li, Xinjian Qiu, Lu Zhou, Dongsheng Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional Chinese herbal medicine, is composed of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (Ge-Gen in Chinese), Coptis chinensis Franch (Huang-Lian), and Cinnamomum cassia (L.) J. Presl (Rou-Gui). GGJTW is used for treatment of diabetes in China, reflecting the potent hypoglycemic effect of its ingredients. However, little is known of the hypoglycemic effect of GGJTW and the underlying metabolic mechanism...
March 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29559348/microrna-24-regulates-vascular-remodeling-via-inhibiting-pdgf-bb-pathway-in-diabetic-rat-model
#7
Jian Yang, Ping Zeng, Jun Yang, Xiaowen Liu, Jiawang Ding, Huibo Wang, Lihua Chen
PURPOSE: Hyperglycemia is the high risk factor of vascular remodeling induced by angioplasty, and neointimal hyperplasia is strongly implicated in the pathogenesis of vascular remodeling caused by carotid artery balloon injury. Studies have shown that MicroRNA 24 (miR-24) plays an important role in angiocardiopathy, However, the role of miR-24 is far from thorough research. In this study, we investigate whether up-regulation of miR-24 by using miR-24 recombinant adenovirus (Ad-miR-24-GFP) can inhibit PDGF-BB signaling pathway and attenuate vascular remodeling in the diabetic rat model...
March 17, 2018: Gene
https://www.readbyqxmd.com/read/29555548/postoperative-period
#8
(no author information available yet)
Follow on from continuous intravenous administration of insulin with an electronic syringe (IVES) is an important element in the postoperative management of a diabetic patient. The basal-bolus scheme is the most suitable taking into account the nutritional supply and variable needs for insulin, reproducing the physiology of a normal pancreas: (i) slow (long-acting) insulin (=basal) which should immediately take over from IVES insulin simulating basal secretion; (ii) ultra-rapid insulin to simulate prandial secretion (=bolus for the meal); and (iii) correction of possible hyperglycaemia with an additional ultra-rapid insulin bolus dose...
March 16, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29543434/point-of-care-determination-of-acetaminophen-levels-with-multi-hydrogen-bond-manipulated-single-molecule-recognition-emuhsir
#9
Yan Zhang, Zhongyuan Huang, Letao Wang, Chunming Wang, Changde Zhang, Thomas E Wiese, Guangdi Wang, Kevin Eugene Riley, Zhe Wang
This work aims to face the challenge of monitoring small molecule drugs accurately and rapidly for point-of-care (POC) diagnosis in current clinical settings. Overdose of acetaminophen (AP), a commonly used OTC analgesic drug, has been determined to be a major cause of acute liver failure in the US and the UK. However, there is no rapid and accurate detection method available for this drug in the emergency room. The present study examined an AP sensing strategy that relies on a previously unexplored strong interaction between AP and the arginine (Arg) molecule...
March 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29502389/second-generation-antipsychotic-and-diabetes-mellitus-in-children-and-adolescents
#10
Carlo Ripoli, Anna Paola Pinna, Faustina Podda, Roberta Zanni, Maria Giada Tronci, Anna Maria Nurchi
Second generation antipsychotics (SGA) are used in children for the treatment of various psychiatric diseases, including pervasive developmental disorders. These drugs can cause metabolic effects as hyperglycemia and diabetes. A 16-year-old young-boy, diagnosed with autism, developed diabetes mellitus type 1 whilst he was on treatment with olanzapine (started 4 months before), clomipramine, valproic acid and lithium. The hypothesis of druginduced diabetes imposed olanzapine interruption and clozapine initiation...
December 13, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/29492362/clozapine-improvement-of-negative-symptoms-of-schizophrenia
#11
Afaque H Khan, Samina Zaidi
We report five cases of treatment-resistant schizophrenia that presented with prominent negative and positive symptoms. They fulfill the criteria of diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). They showed lack of response despite receiving multiple trials of first and second generation psychotropic agents. We decided to give these patients a trial of clozapine to improve their negative and positive symptoms as well as their quality of life...
December 20, 2017: Curēus
https://www.readbyqxmd.com/read/29492060/neutrophil-lymphocyte-ratio-nlr-a-well-assessment-tool-of-glycemic-control-in-type-2-diabetic-patients
#12
Mazhar Hussain, Muhammad Zafar Majeed Babar, Lubna Akhtar, Muhammad Shahbaz Hussain
Background and Objective: Increased neutrophil lymphocyte ratio (NLR) is a marker as well as predictor of various cardiac and non cardiac disorders. Our aim was to assess the relationship between NLR and different level of glycemic control in type 2 diabetic patients. Methods: An observational study was conducted at diabetic clinic of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from September 2016 to February 2017 in which 330 type 2 diabetic patients were randomly divided in to three groups based upon diabetes control according to ADA criteria...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29455909/elevated-tissue-sodium-deposition-in-patients-with-type-2-diabetes-on-hemodialysis-detected-by-23-na-magnetic-resonance-imaging
#13
Christoph Kopp, Peter Linz, Carolin Maier, Peter Wabel, Matthias Hammon, Armin M Nagel, Daniela Rosenhauer, Stephan Horn, Michael Uder, Friedrich C Luft, Jens Titze, Anke Dahlmann
Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this, 23 Na magnetic resonance imaging (23 Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by 1 H MRI and tissue sodium content by 23 Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients...
May 2018: Kidney International
https://www.readbyqxmd.com/read/29417017/how-much-do-persons-with-diabetes-in-a-rural-area-of-south-india-know-about-diabetes-management-a-step-toward-person-centered-care
#14
Marie Gilbert Majella, Palanivel Chinnakali, Bijay Nanda Naik, Pruthu Thekkur, Bharath Nag, Gomathi Ramaswamy
Introduction: The burden of diabetes mellitus is increasing worldwide, more so in developing countries. Optimal diabetes care depends on adherence to management protocol, which can be brought about by shared decision-making. Patient's knowledge on life-threatening complications and preventive strategies for the same is a prerequisite for shared decision-making. Hence, this study was carried out among diabetes patients to assess the level of knowledge on different aspects of diabetes management...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29393699/clinical-implications-of-combined-glucose-intolerance-in-treatment-na%C3%A3-ve-hypertensive-patients
#15
Beom-June Kwon, Dae-Won Kim, Mahn-Won Park, Sung-Ho Her, Ha Wook Park, Kiyuk Chang, Wook-Sung Chung, Ki-Bae Seung, Tai-Ho Rho
BACKGROUND: This study is the first study to evaluate clinical significance of combined glucose intolerance (CGI) in treatment-naïve hypertensive patients. METHODS: We compared the results of demographic, anthropometric, clinical, laboratory examinations, echocardiography, arterial stiffness, central blood pressure (BP) and ambulatory BP monitoring (ABPM) between the groups according to fasting blood sugar (FBS), postprandial 2 hour blood glucose (PP2) and gender in treatment-naïve hypertensive patients...
February 2, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29390917/an-analysis-of-diabetes-mobile-applications-features-compared-to-aade7%C3%A2-addressing-self-management-behaviors-in-people-with-diabetes
#16
Qing Ye, Uzma Khan, Suzanne A Boren, Eduardo J Simoes, Min Soon Kim
BACKGROUND: Diabetes self-management (DSM) applications (apps) have been designed to improve knowledge of diabetes and self-management behaviors. However, few studies have systematically examined if diabetes apps followed the American Association of Diabetes Educators (AADE) Self-Care Behaviors™ guidelines. The purpose of this study was to compare the features of current DSM apps to the AADE7™ guidelines. METHODS: In two major app stores (iTunes and Google Play), we used three search terms "diabetes," "blood sugar," and "glucose" to capture a wide range of diabetes apps...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29338325/comparative-evaluations-of-randomly-selected-four-point-of-care-glucometer-devices-in-addis-ababa-ethiopia
#17
Mistire Wolde, Getahun Tarekegn, Tedla Kebede
BACKGROUND: Point-of-care glucometer (PoCG) devices play a significant role in self-monitoring of the blood sugar level, particularly in the follow-up of high blood sugar therapeutic response. The aim of this study was to evaluate blood glucose test results performed with four randomly selected glucometers on diabetes and control subjects versus standard wet chemistry (hexokinase) methods in Addis Ababa, Ethiopia. METHOD: A prospective cross-sectional study was conducted on randomly selected 200 study participants (100 participants with diabetes and 100 healthy controls)...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29336274/controlling-diabetes-continuous-glucose-monitoring-for-the-older-adult
#18
Caren McHenry Martin, Catherine Travis
Obtaining and maintaining adequate blood glucose control in the older adult with diabetes offers unique challenges. Intensive blood glucose control can increase the risk of hypoglycemia, which can be particularly risky in the older adult. Adding and adjusting diabetes medications in elderly patients with multiple comorbidities and numerous other medications can also be challenging. The use of professional continuous glucose monitors-which are worn by the patient for up to two weeks and record blood sugars every 5 to 15 minutes-provides pharmacists and other health care professionals with valuable data for managing the care of the older adult with diabetes...
January 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29285451/the-prevalence-of-new-onset-diabetes-mellitus-after-renal-transplantation-in-patients-with-immediate-posttransplant-hyperglycemia-in-a-tertiary-care-centre
#19
Saba Samad Memon, Nikhil Tandon, Sandeep Mahajan, V K Bansal, Asuri Krishna, Arunkumar Subbiah
Objectives: This study aimed to determine the prevalence of immediate posttransplant hyperglycemia and new onset diabetes after renal transplantation (NODAT). It also aims at answering whether posttransplant hyperglycemia per se is a risk factor for future development of NODAT. Methods: A retrospective study was conducted among patients undergoing kidney transplantation under a single surgical unit in a tertiary care hospital in the past 5 years. All known patients with diabetes were excluded from the study...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29282052/identifying-gaps-in-the-continuum-of-care-for-hypertension-and-diabetes-in-two-indian-communities
#20
Rose Gabert, Marie Ng, Ruchi Sogarwal, Miranda Bryant, R V Deepu, Claire R McNellan, Sunil Mehra, Bryan Phillips, Marissa Reitsma, Blake Thomson, Shelley Wilson, Alexandra Wollum, Emmanuela Gakidou, Herbert C Duber
BACKGROUND: Non-communicable diseases (NCDs) represent the largest, and fastest growing, burden of disease in India. This study aimed to quantify levels of diagnosis, treatment, and control among hypertensive and diabetic patients, and to describe demand- and supply-side barriers to hypertension and diabetes diagnosis and care in two Indian districts, Shimla and Udaipur. METHODS: We conducted household and health facility surveys, as well as qualitative focus group discussions and interviews...
December 27, 2017: BMC Health Services Research
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