keyword
https://read.qxmd.com/read/38628966/the-inactivation-of-tolc-sensitizes-escherichia-coli-to-perturbations-in-lipopolysaccharide-transport
#1
JOURNAL ARTICLE
Shawna Zhu, Mary Kate Alexander, Telmo O Paiva, Kenneth Rachwalski, Anh Miu, Yiming Xu, Vishal Verma, Mike Reichelt, Yves F Dufrêne, Eric D Brown, Georgina Cox
The Escherichia coli outer membrane channel TolC complexes with several inner membrane efflux pumps to export compounds across the cell envelope. All components of these complexes are essential for robust efflux activity, yet E. coli is more sensitive to antimicrobial compounds when tolC is inactivated compared to the inactivation of genes encoding the inner membrane drug efflux pumps. While investigating these susceptibility differences, we identified a distinct class of inhibitors targeting the core-lipopolysaccharide translocase, MsbA...
May 17, 2024: IScience
https://read.qxmd.com/read/38603465/association-between-musculoskeletal-pain-and-exposures-to-awkward-postures-during-work-a-compositional-analysis-approach
#2
JOURNAL ARTICLE
Fredrik Klæboe Lohne, Kailiang Xu, Marius Steiro Fimland, Javier Palarea-Albaladejo, Skender Redzovic
OBJECTIVES: This study aimed to explore the association between arm elevation and neck/shoulder pain, and trunk forwarding bending and low back pain among home care workers. METHODS: Home care workers (N = 116) from 11 home care units in Trondheim, Norway, filled in pain assessment and working hours questionnaire, and wore 3 accelerometers for up to 7 consecutive days. Work time was partitioned into upright awkward posture, nonawkward posture, and nonupright time, i...
April 11, 2024: Annals of Work Exposures and Health
https://read.qxmd.com/read/38576412/the-strategies-used-to-balance-health-and-work-across-the-solid-organ-transplantation-trajectory
#3
JOURNAL ARTICLE
Keira Gaudet, Marc Corbiere, Tianyan Chen, Heloise Cardinal, Marie Achille
Introduction: Workers who undergo solid organ transplantation report frequent conflicts between the unpredictable demands of their health condition and the rigid requirements of their employer and of health services. The present study aimed to describe the self-management strategies adopted by workers while staying at work before transplantation and during sustainable return-to-work posttransplantation. Methods: Fifteen employed kidney, liver, and lung transplant recipients were recruited from 2 large urban university health centers in Montreal, Canada...
April 5, 2024: Progress in Transplantation
https://read.qxmd.com/read/38566834/work-participation-and-the-covid-19-pandemic-an-observational-study-in-people-with-inflammatory-rheumatic-diseases-and-population-controls
#4
JOURNAL ARTICLE
Maarten Butink, Laura Boekel, Annelies Boonen, Angelique deRijk, Gertjan Wolbink, Casper Webers
OBJECTIVE: During the coronavirus disease 2019 (COVID-19) crisis, people with inflammatory rheumatic diseases (iRDs) might have been more vulnerable for adverse work outcomes (AWOs) and restrictions in work ability and work performance. Our objectives were to compare AWOs during the pandemic and current work ability between iRD patients and controls, understand which patients are most vulnerable for these outcomes and (3) explore the role of work characteristics on work performance while working remotely...
2024: Rheumatology Advances in Practice
https://read.qxmd.com/read/38561922/factors-affecting-patients-journey-with-primary-healthcare-services-during-mental-health-related-sick-leave
#5
JOURNAL ARTICLE
Justine Labourot, Émilie Pinette, Nadia Giguère, Matthew Menear, Cynthia Cameron, Elyse Marois, Brigitte Vachon
CONTEXT: Best practice guidelines for the recovery and return to work (RTW) of people with mental disorders recommend access to the services of an interdisciplinary team combining pharmacological, psychological and work rehabilitation interventions. In the Canadian context, primary healthcare services are responsible for providing these services for people with common mental disorders, such as depressive or anxiety disorders. However, not everyone has easy access to these recommended primary healthcare services, and previous studies suggest that multiple personal, practice-related and organizational factors can influence the patient's journey...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38533974/return-to-work-after-refractory-out-of-hospital-cardiac-arrest-in-patients-managed-with-or-without-extracorporeal-cardiopulmonary-resuscitation-a-nationwide-register-based-study
#6
JOURNAL ARTICLE
Emilie Gregers, Kristian Kragholm, Louise Linde, Sivagowry Rasalingam Mørk, Jo Bønding Andreasen, Christian Juhl Terkelsen, Jens Flensted Lassen, Jacob Eifer Møller, Helle Laugesen, Morten Smerup, Jesper Kjærgaard, Peter Hasse Møller-Sørensen, Lene Holmvang, Christian Torp-Pedersen, Christian Hassager, Helle Søholm
BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out-of-hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA. METHODS AND RESULTS: Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry-based study included 805 patients with refractory OHCA in the working age (18-65 years) who were employed before OHCA (2% of the total OHCA cohort)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38501735/patient-reported-experiences-with-refractory-or-unexplained-chronic-cough-a-qualitative-analysis
#7
JOURNAL ARTICLE
Vishal Bali, Jonathan Schelfhout, Mandel R Sher, Anju Tripathi Peters, Gayatri B Patel, Margaret Mayorga, Diana Goss, Carla DeMuro Romano
BACKGROUND: Chronic cough, defined as a cough lasting 8 or more weeks, affects up to 10% of adults. Refractory chronic cough (RCC) is a cough that is uncontrolled despite comprehensive investigation and treatment of comorbid conditions while unexplained chronic cough (UCC) is a cough with no identifiable cause despite extensive evaluation of comorbid conditions. RCC and UCC are often poorly controlled. Understanding individuals' lived experience of the symptoms and impacts of these conditions may guide therapeutic strategies...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38489212/evaluation-of-absenteeism-and-presenteeism-status-of-factory-employees
#8
JOURNAL ARTICLE
Belgin Oral, Yavuzalp Solak, Hasan Durmuş
BACKGROUND: While absenteeism refers to not attending work, presenteeism is defined as not being present at work. These two conditions, which negatively affect employee health, can be indicators of work efficiency, work peace, work safety and work engagement. OBJECTIVE: Several factors were evaluated in this study concerning absenteeism and presenteeism among factory workers. METHODS: This cross-sectional study was conducted among workers in a factory operating in a heavy industry in southern Turkey in 2021...
March 9, 2024: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://read.qxmd.com/read/38484612/occupational-exposure-to-particulate-matter-and-staff-sickness-absence-on-the-london-underground
#9
JOURNAL ARTICLE
Justie Mak, Johanna Feary, André F S Amaral, Emma Marczylo, Paul Cullinan, David C Green
The London Underground (LU) employs over 19,000 staff, some of whom are exposed to elevated concentrations of particulate matter (PM) within the network. This study quantified the occupational exposure of LU staff to subway PM and investigated the possible association with sickness absence (SA). A job exposure matrix to quantify subway PM2.5 staff exposure was developed by undertaking measurement campaigns across the LU network. The association between exposure and SA was evaluated using zero-inflated mixed-effects negative binomial models...
February 27, 2024: Environment International
https://read.qxmd.com/read/38475747/impact-of-psychosocial-work-factors-on-risk-of-medically-certified-sick-leave-due-to-common-mental-disorders-a-nationwide-prospective-cohort-study-of-norwegian-home-care-workers
#10
JOURNAL ARTICLE
Rigmor Harang Knutsen, Morten Birkeland Nielsen, Lars-Kristian Lunde, Øivind Skare, Håkon A Johannessen
BACKGROUND: The Norwegian home care services experience a high level of sick leave, a large proportion of which is due to common mental disorders. A substantial number of such cases can be attributed to psychosocial factors at work, but more knowledge about occupation-specific risk factors is needed to develop targeted preventive measures to reduce sick leave levels. The aim of this study is to identify the most prominent psychosocial work factors influencing the risk of sick leave spells due to common mental disorders...
March 12, 2024: BMC Public Health
https://read.qxmd.com/read/38462912/covid-19-mitigation-activities-in-inpatient-psychiatry-were-associated-with-patient-reported-institutional-betrayal-changes-in-trust-and-fear-of-getting-sick
#11
JOURNAL ARTICLE
Francis J Ochman, Morgan C Shields
Institutional betrayal occurs when the institutions that people depend on fail to protect them from harm, which was exemplified by a failure to manage COVID-19 risks. Inpatient psychiatry provides a rich context for which to understand the effects of institutional betrayal, and this is amplified in the context of the COVID-19 pandemic. Using a retrospective cohort design, we administered an online survey to former patients (n = 172) of inpatient psychiatry hospitalized at the height of the COVID-19 pandemic (March 2020 to February 2021) to understand the relationship between facilities' use of COVID-19 mitigation activities (ie, offering or requiring face masks, keeping patients and staff 6 feet apart, access to hand sanitizer, use of telemedicine for clinical consults, and routine cleanliness of the unit) and former patients' reports of institutional betrayal, changes in their trust in mental healthcare providers, fear of getting sick, and having contracted or witnessed someone else contract COVID-19...
2024: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://read.qxmd.com/read/38459570/improving-access-to-melarsomine-therapy-treating-canine-heartworm-infection-in-a-high-volume-outpatient-community-clinic-setting
#12
JOURNAL ARTICLE
Meghan B Still, Dana Tedesco, Christina Hawkins, Holly Putnam
BACKGROUND: Models that provide high-quality veterinary care for more affordable prices are emerging, but not well documented outside of wellness and preventative care. Effective treatment guidelines for heartworm disease have been developed by the American Heartworm Society; however, not all owners are able to access treatment due to the high costs associated with sick and emergency care services. METHODS: To increase access to high-quality adulticidal treatment of canine heartworm disease, we developed and implemented a technician-leveraged heartworm treatment protocol for high-volume, outpatient community clinic settings based on the American Heartworm Society guidelines...
March 8, 2024: Parasites & Vectors
https://read.qxmd.com/read/38459468/bidirectional-associations-between-workplace-bullying-and-sickness-absence-due-to-common-mental-disorders-a-propensity-score-matched-cohort-study
#13
JOURNAL ARTICLE
Rebecka Holmgren, Alessandra Grotta, Kristin Farrants, Linda L Magnusson Hanson
BACKGROUND: The link between workplace bullying and poor mental health is well-known. However, little is known about the prospective and potentially reciprocal association between workplace bullying and mental health-related sickness absence. This 2-year prospective study examined bidirectional associations between exposure to workplace bullying and sickness absence due to common mental disorders (SA-CMD) while controlling for confounding factors from both work and private life. METHODS: The study was based on propensity score-matched samples (N = 3216 and N = 552) from the Swedish Longitudinal Occupational Survey of Health, using surveys from years 2012, 2014 and 2016...
March 8, 2024: BMC Public Health
https://read.qxmd.com/read/38451073/a-man-in-his-sixties-with-life-threatening-febrile-illness-after-travel-abroad
#14
JOURNAL ARTICLE
Bjørn Blomberg, Trond Bruun, Stina Jordal, John Olav Alvsvåg, Kristine Mørch
BACKGROUND: African sleeping sickness is a neglected tropical disease seldom seen in European travellers. CASE PRESENTATION: While working in Eastern Africa, a Norwegian man in his sixties developed weakness and fever. He was prescribed doxycycline after a negative malaria rapid test. On the third day of illness he returned to Norway and was admitted to the hospital upon arrival. On admission he was somnolent with fever, tachypnoea, tachycardia, jaundice, a hyperaemic rash, oliguria and haematuria...
February 27, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://read.qxmd.com/read/38441440/non-medical-interventions-to-enhance-return-to-work-for-people-with-cancer
#15
JOURNAL ARTICLE
Angela Gem de Boer, Sietske J Tamminga, Julitta S Boschman, Jan L Hoving
BACKGROUND: People with cancer are 1.4 times more likely to be unemployed than people without a cancer diagnosis. Therefore, it is important to investigate whether programmes to enhance the return-to-work (RTW) process for people who have been diagnosed with cancer are effective. This is an update of a Cochrane review first published in 2011 and updated in 2015. OBJECTIVES: To evaluate the effectiveness of non-medical interventions aimed at enhancing return to work (RTW) in people with cancer compared to alternative programmes including usual care or no intervention...
March 5, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38439021/age-and-healthy-lifestyle-behavior-s-disparities-and-similarities-on-knowledge-of-myocardial-infarction-symptoms-and-risk-factors-among-public-and-outpatients-in-a-resource-limited-setting-cross-sectional-study-in-greater-gaborone-botswana
#16
JOURNAL ARTICLE
Ookeditse Ookeditse, Kebadiretse K Ookeditse, Thusego R Motswakadikgwa, Gosiame Masilo, Yaone Bogatsu, Baleufi C Lekobe, Mosepele Mosepele, Henrik Schirmer, Stein H Johnsen
OBJECTIVES: In this cross-sectional study from Botswana, we investigated knowledge of myocardial infarction (MI) symptoms and risk factors among the general public and outpatients with MI risk factors based on age and lifestyle behaviors, in addition to assessing associations with sociodemographic and MI risk factors. METHOD: Open-ended questionnaires about 8 MI symptoms and 10 risk factors, were administered by research assistants to a representative selection of outpatients (n = 525) and the public (n = 2248)...
March 4, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38437100/the-effects-of-secondary-task-demands-on-cybersickness-in-active-exploration-virtual-reality-experiences
#17
JOURNAL ARTICLE
Roshan Venkatakrishnan, Rohith Venkatakrishnan, Ryan Canales, Balagopal Raveendranath, Dawn M Sarno, Andrew C Robb, Wen-Chieh Lin, Sabarish V Babu
Active exploration in virtual reality (VR) involves users navigating immersive virtual environments, going from one place to another. While navigating, users often engage in secondary tasks that require attentional resources, as in the case of distracted driving. Inspired by research generally studying the effects of task demands on cybersickness (CS), we investigated how the attentional demands specifically associated with secondary tasks performed during exploration affect CS. Downstream of this, we studied how increased attentional demands from secondary tasks affect spatial memory and navigational performance...
March 4, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38433720/psychotherapy-duration-and-work-disability-a-prospective-finnish-register-study
#18
JOURNAL ARTICLE
Sanna Selinheimo, Kia Gluschkoff, Johanna Kausto, Jarno Turunen, Ari Väänänen
INTRODUCTION: The influence of psychotherapy duration on common mental disorder (CMD) outcomes remains a topic of ongoing debate. Whereas most research has focused on CMD symptom change, the evidence on the psychotherapy duration of subsequent CMD-related work disability and the change in psychotropic drug purchases is scarce. METHODS: We used a register-based cohort representing 33% of the Finnish population. The participants included working-age individuals (N = 12,047, 76% women, mean age = 36) who initiated long-term psychotherapy, between 2014 and 2017...
March 4, 2024: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/38431615/pre-job-loss-grief-reactions-and-work-attachment-among-sick-listed-employees-introduction-of-the-imminent-job-loss-scale
#19
JOURNAL ARTICLE
Janske H W van Eersel, Inge L Hulshof, Miriam I Wickham, Geert E Smid, Paul A Boelen
BACKGROUND: With this study, we aimed to explore the emotional experiences of sick-listed employees facing imminent job loss, as this emotional distress may hinder successful job search outcomes. The study had two objectives: (1) to develop and validate the Imminent Job Loss Scale (IJLS) for assessing pre-job loss grief reactions and (2) to examine its relationship to work attachment. METHODS: Development of the 9-item IJLS was carried out using feedback from an expert panel, consisting of five academic experts in grief and labour, five re-integration specialists, and five sick-listed employees facing imminent job loss...
March 2, 2024: BMC Psychology
https://read.qxmd.com/read/38402092/why-do-physicians-go-to-work-when-they-are-sick-presenteeism-at-different-career-stages
#20
JOURNAL ARTICLE
O Urbano Gonzalo, B Marco Gómez, C Pérez Álvarez, A Gállego Royo, I Sebastián Sánchez, M P Astier Peña
INTRODUCTION AND OBJECTIVE: Physicians find it difficult to take on the role of the patient and they show unusual behaviors when ill. One of these behaviors is presenteeism, which is working while sick. The objective of this research is to analyze the factors that contribute to the phenomenon of presenteeism in Spanish physicians. MATERIAL AND METHODS: Mixed methodology study: one national survey through the General Council of Medical Associations website (quantitative part), 22 semistructured interviews with sick residents and practicing physicians, and three focus groups involving professionals from the occupational health services (qualitative)...
February 23, 2024: Journal of Healthcare Quality Research
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