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Liposomes and skin

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https://www.readbyqxmd.com/read/27918967/nanoencapsulation-an-efficient-and-promising-approach-to-maximize-wound-healing-efficacy-of-curcumin-a-review-of-new-trends-and-state-of-the-art
#1
REVIEW
Zahid Hussain, Hnin Ei Thu, Shiow-Fern Ng, Shahzeb Khan, Haliza Katas
Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life...
November 30, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27904816/an-unusual-presentation-of-nocardiosis-in-an-allogeneic-transplant-recipient
#2
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Terenig Terjanian
Nocardiosis is a rare cause of opportunistic infection post hematopoietic stem cell transplant (HSCT) occurring in about 0.3% of patients. The risk factors include delayed immune reconstitution, prolonged neutropenia, and graft-versus-host disease. The most common site of infection is the lung, followed by the brain and the skin. Concomitant pulmonary and central nervous system (CNS) nocardiosis is an extremely rare entity as presented in our case. We present the case of a 72-year-old male at 137 days post transplant presenting with complaints of headache and slurred speech...
October 17, 2016: Curēus
https://www.readbyqxmd.com/read/27865609/recent-advances-in-lipid-based-vesicles-and-particulate-carriers-for-topical-and-transdermal-application
#3
REVIEW
Shashank Jain, Niketkumar Patel, Mansi K Shah, Pinak Khatri, Namrata Vora
In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery, and interest in life cycle management strategies among pharmaceutical companies. Literature review of recent publications indicates that among various skin delivery systems, lipid-based delivery systems (vesicular carriers and lipid particulate systems) have been the most successful. Vesicular carriers consist of liposomes, ultradeformable liposomes, and ethosomes, while lipid particulate systems consist of lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers...
November 16, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27862750/skin-lesion-in-a-patient-with-acute-myeloid-leukemia
#4
Atul Kothari, Sara C Shalin, Juan Carlos Crescencio, Mary J Burgess
We present the case of a 51-year-old man with acute myeloid leukemia who developed fevers with a skin lesion following the first cycle of induction chemotherapy. Skin biopsy showed evidence of invasive fungal infection. Cultures remained negative, but polymerase chain reaction on tissue detected Rhizopus oryzae complex. Patient was started on liposomal amphotericin B and underwent surgical debridement. He was switched to posaconazole, with plans for allogeneic hematopoetic stem cell transplant in the future...
November 16, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27856266/local-injection-of-liposomal-bupivacaine-combined-with-intravenous-dexamethasone-reduces-postoperative-pain-and-hospital-stay-after-shoulder-arthroplasty
#5
Howard D Routman, Logan R Israel, Molly A Moor, Andrew D Boltuch
BACKGROUND: Alternative techniques have been developed to address pain after shoulder arthroplasty and are well documented. We evaluated the effect of adding intraoperative liposomal bupivacaine and intravenous dexamethasone during shoulder arthroplasty. METHODS: We retrospectively reviewed 2 consecutive cohorts undergoing elective shoulder arthroplasty. The 24 patients in cohort 1 and the 31 patients in cohort 2 received perioperative multimodal management with preoperative and postoperative intravenous and oral narcotics, gabapentin, nonsteroidal anti-inflammatory drugs, acetaminophen, and single-injection interscalene block...
November 15, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27837534/elastic-liposomes-for-topical-and-transdermal-drug-delivery
#6
Heather A E Benson
Elastic liposomes have been developed and evaluated as novel topical and transdermal delivery systems. They share some similarities to conventional liposomes but their composition is designed to confer flexibility and elasticity in the lipid bilayer structure. Elastic liposomes are applied non-occluded to the skin and are reported to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. They have been investigated as drug carriers for a range of small molecules, peptides, proteins, and vaccines, both in vitro and in vivo...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27834056/ultradeformable-liposomes-a-novel-vesicular-carrier-for-enhanced-transdermal-delivery-of-procyanidins-effect-of-surfactants-on-the-formation-stability-and-transdermal-delivery
#7
Rencai Chen, Rongli Li, Qian Liu, Chao Bai, Benlin Qin, Yue Ma, Jing Han
The aims of this work were to develop a novel vesicular carrier, procyanidins, ultradeformable liposomes (PUDLs), to expand the applications for procyanidins, and increase their stability and transdermal delivery. In this study, we prepared procyanidins ultradeformable liposomes using thin film hydration method and evaluated their encapsulation efficiency, vesicle deformability, storage stability, and skin permeation in vitro. The influence of different surfactants on the properties of PUDLs was also investigated...
November 10, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27832955/lipid-vesicular-nanocarrier-quick-encapsulation-efficiency-determination-and-transcutaneous-application
#8
Yibang Zhang, Weibeng Ng, Xue Feng, Fangying Cao, Huaxi Xu
Nanoscale delivery systems have been widely investigated to overcome the penetration barrier of stratum corneum for effective transcutaneous application. The aim of this study is the development of effective vesicular formulations of ovalbumin and saponin which are able to promote penetration through the skin layers. Three kinds of vesicular formulations have been investigated as carriers, including liposomes, transfersomes and ethosomes, in which cholesterol and/or cationic lipid stearylamine are incorporated...
November 8, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27829611/sodium-lauryl-sulfate-stimulates-the-generation-of-reactive-oxygen-species-through-interactions-with-cell-membranes
#9
Taeko Mizutani, Ryota Mori, Misaki Hirayama, Yuki Sagawa, Kenji Shimizu, Yuri Okano, Hitoshi Masaki
Sodium lauryl sulfate (SLS), a representative anionic surfactant, is well-known to induce rough skin following single or multiple topical applications. The mechanism by which SLS induces rough skin is thought to result from the disruption of skin moisture function consisting of NMF and epidermal lipids. However, a recent study demonstrated that topically applied SLS easily penetrates into the living cell layers of the epidermis, which suggests that physiological alterations of keratinocytes might cause the SLS-induced rough skin...
December 1, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27829536/anticancer-activity-of-all-trans-retinoic-acid-loaded-liposomes-on-human-thyroid-carcinoma-cells
#10
Maria Chiara Cristiano, Donato Cosco, Christian Celia, Andra Tudose, Rosario Mare, Donatella Paolino, Massimo Fresta
All-trans retinoic acid (ATRA) is an anti-tumor compound, exerting different anti-cancer effects on different types of cancer cells. Unfortunately, retinoids are also characterized by certain side effects following systemic administration, such as the burning of skin and general malaise. The highly variable degree of bioavailability of ATRA plus its tendency to induce its own destruction through metabolic degradation following oral treatment necessitate the development of alternative formulations. The aim of this work is to evaluate the physico-chemical properties of unilamellar, ATRA-containing liposomes and to investigate the cytotoxic activity of this potential nanomedicine on human thyroid carcinoma cells...
November 4, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27825918/combination-of-grape-extract-silver-nanoparticles-and-liposomes-a-totally-green-approach
#11
Ines Castangia, Francesca Marongiu, Maria Letizia Manca, Raffaello Pompei, Fabrizio Angius, Andrea Ardu, Anna Maria Fadda, Maria Manconi, Guido Ennas
In the present work, silver nanoparticles were prepared using a totally green procedure combining silver nitrate and an extract of grape pomace as a green source. Additionally, nanoparticles were stabilized using phospholipid and water and/or a mixture of water and propylene glycol (PG). To the best of our knowledge, grape-silver nanoparticle stabilized liposomes or PG-liposomes were formulated, for the first time, combining the residual products of wine-made industry, silver nitrate and phospholipids, avoiding the addition of hazardous substances to human health and the environment, in an easy, scalable and reproducible method...
November 4, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27825863/comparison-of-liposomal-and-nlc-nanostructured-lipid-carrier-formulations-for-improving-the-transdermal-delivery-of-oxaprozin-effect-of-cyclodextrin-complexation
#12
N Mennini, M Cirri, F Maestrelli, P Mura
The combined strategy of drug-cyclodextrin (CD) complexation and complex loading into nanocarriers (deformable liposomes or nanostructured lipid carriers (NLC)), was exploited to develop effective topical formulations for oxaprozin transdermal administration. Oxaprozin was loaded as ternary complex with randomly-methylated-ßCD and arginine, selected as the best system in improving drug solubility. The colloidal dispersions, characterized for particle size, zeta-potential and entrapment efficiency, were investigated for drug permeation properties in comparison with a plain drug aqueous suspension, a ternary complex aqueous solution and a plain drug liposomal or NLC dispersion...
November 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27819148/co-delivery-of-curcumin-and-stat3-sirna-using-deformable-cationic-liposomes-to-treat-skin-cancer
#13
Anup Jose, Suman Labala, Venkata Vamsi Krishna Venuganti
Skin cancer is one of the most widely prevalent cancer types with over expression of multiple oncogenic signaling molecules including STAT3. Curcumin is a natural compound with effective anti-cancer properties. The objective of this work was to investigate the liposomal co-delivery of curcumin and STAT3 siRNA by non-invasive topical iontophoretic application to treat skin cancer. Curcumin was encapsulated in cationic liposomes and then complexed with STAT3 siRNA. The liposomal nanocomplex was characterized for particle size, zeta-potential, drug release and stability...
November 7, 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27815492/preclinical-biodistribution-and-safety-evaluation-of-a-pbi-shrna-stmn1-lipoplex-after-subcutaneous-delivery
#14
Zhaohui Wang, Christopher M Jay, Courtney Evans, Padmasini Kumar, Connor Phalon, Donald D Rao, Neil Senzer, John Neumantis
Stathmin-1 (STMN1) is a microtubule-destabilizing protein which is overexpressed in cancer. Its overexpression is associated with poor prognosis and also serves as a predictive marker to taxane therapy. We have developed a proprietary bi-functional shRNA (bi-shRNA) platform to execute RNA interference (RNAi)-mediated gene silencing and a liposome-carrier complex to systemically deliver the pbi-shRNA plasmids. In vitro and in vivo testing demonstrated efficacy and specificity of pbi-shRNA plasmid in targeting STMN1 (Phadke et al...
November 4, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27802901/percutaneous-penetration-of-anticancer-agents-past-present-and-future
#15
REVIEW
Kevin Ita
Cancer occurs as a result of alterations in oncogenes, tumor-suppressor genes, and microRNA genes. Over the past few decades, efforts have been made to understand the dominant oncogenes and tumor suppressor genes whose respective activation/upregulation or loss of function serve to impart aberrant properties on normal cells. Cancer continues to be a source of public health concern due to widespread prevalence, morbidity and mortality. The most common types include but are not limited to lung, prostate, colorectal, breast, ovarian and skin cancers...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27787222/cutaneous-leishmaniasis-caused-by-leishmania-infantum-in-southern-israel
#16
Shalom Ben-Shimol, Orli Sagi, Amir Horev, Yonat Shemer Avni, Mati Ziv, Klaris Riesenberg
Cutaneous leishmaniasis (CL) caused by Leishmania major is common in southern Israel, while Leishmania infantum (sub-strain of L. donovani, causing zoonotic visceral leishmaniasis) infections were rarely reported in Israel and only in other regions. We report the first case of L. infantum infection in southern Israel, presented atypically as CL in an immunosuppressed 47-year old male. The patient was treated with liposomal amphotericin-B and recovered, without extra-cutaneous complications. Diagnosis of L. infantum CL was confirmed by microscopic identification of amastigotes in Gimsa-stained smear of skin lesion, positive blood serology and a positive polymerase chain reaction (PCR) amplification of the internal transcribed spacer 1 genes (ITS1) and restriction fragment length polymorphism (ITS1 PCR-RFLP)...
December 1, 2016: Acta Parasitologica
https://www.readbyqxmd.com/read/27777066/psoralen-loaded-liposomal-nanocarriers-for-improved-skin-penetration-and-efficacy-of-topical-puva-in-psoriasis
#17
Sindhu Doppalapudi, Anjali Jain, Dhiraj Kumar Chopra, Wahid Khan
Psoralen in combination with ultraviolet A radiation (PUVA) is an FDA recommended therapy for clinical application in the management of severe recalcitrant psoriasis. Psoralen acts by intercalation of DNA and upon exposure to UV-A, it forms monoadducts which inturn induce apoptosis. Poor skin deposition, weak percutaneous permeability of psoralen and adverse effects of severe burning, blisters, pigmentation associated with conventional topical psoralen vehicles hinders the therapeutic efficacy and safety of topical PUVA...
October 21, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27742281/cryptococcosis-in-renal-transplant-recipients-a-single-center-experience
#18
S Marques, R Carmo, I Ferreira, M Bustorff, S Sampaio, M Pestana
BACKGROUND: In solid organ transplant patients, 8% of invasive fungal infections are attributed to Cryptococcus. The aim of this study was to determine the frequency, risk factors, clinical characteristics, and outcome of kidney transplant recipients (TR) infected with Cryptococcus. CASE SERIES: Between 2007 and 2014, a total of 500 kidney transplantations were performed at São João Hospital, in Porto, Portugal. Six infections by C. neoformans were reported, an incidence of 1...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27706120/effect-of-liposomes-vitamins-a-and-e-nasal-spray-in-reducing-the-healing-time-after-septoplasty-with-concurrent-turbinate-surgery-in-adolescents
#19
Filippo Ricciardiello, Elena Cantone, Teresa Abate, Antonella M Di Lullo, Flavia Oliva, Maurizio Iengo, Giuseppe De Bernardo
BACKGROUND: This study evaluates endoscopic and quality of life (QoL) outcomes in two groups, composed by both allergic (A) and non-allergic (N-A) adolescents undergoing septoplasty with concurrent turbinate surgery by radiofrequency treated after surgery with nasal spray containing liposomes and vitamins A and E. METHODS: This double-blind randomized study was carried out on 40 patients (22 males, 18 females, mean age 15.5 ± 1.0 years) undergoing septoplasty and volumetric tissue reduction of inferior turbinates by radiofrequency for post-traumatic deformities and severe nasal obstruction...
October 5, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27701965/saksenaea-erythrospora-an-emerging-mucoralean-fungus-causing-severe-necrotizing-skin-and-soft-tissue-infections-a-study-from-a-tertiary-care-hospital-in-north-india
#20
Jagdish Chander, Nidhi Singla, Mandeep Kaur, Rajpal Singh Punia, Ashok Attri, Ana Alastruey-Izquierdo, José F Cano-Lira, Alberto Miguel Stchigel, Josep Guarro
BACKGROUND: Saksenaea erythrospora is an emerging and recently described pathogenic fungus mainly causing invasive cutaneous infections. Globally, very few human cases, caused by S. erythrospora, have been reported. In India, among the genus Saksenaea, S. vasiformis was the only reported pathogenic species, until recently when a case of fungal rhinosinusitis was reported to be caused by S. erythrospora. We observed five human cases of necrotizing skin and soft tissue infections caused by S...
October 4, 2016: Infectious Diseases
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