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Liposomes and skin

S Marques, R Carmo, I Ferreira, M Bustorff, S Sampaio, M Pestana
BACKGROUND: In solid organ transplant patients, 8% of invasive fungal infections are attributed to Cryptococcus. The aim of this study was to determine the frequency, risk factors, clinical characteristics, and outcome of kidney transplant recipients (TR) infected with Cryptococcus. CASE SERIES: Between 2007 and 2014, a total of 500 kidney transplantations were performed at São João Hospital, in Porto, Portugal. Six infections by C. neoformans were reported, an incidence of 1...
September 2016: Transplantation Proceedings
Filippo Ricciardiello, Elena Cantone, Teresa Abate, Antonella M Di Lullo, Flavia Oliva, Maurizio Iengo, Giuseppe De Bernardo
BACKGROUND: This study evaluates endoscopic and quality of life (QoL) outcomes in two groups, composed by both allergic (A) and non-allergic (N-A) adolescents undergoing septoplasty with concurrent turbinate surgery by radiofrequency treated after surgery with nasal spray containing liposomes and vitamins A and E. METHODS: This double-blind randomized study was carried out on 40 patients (22 males, 18 females, mean age 15.5 ± 1.0 years) undergoing septoplasty and volumetric tissue reduction of inferior turbinates by radiofrequency for post-traumatic deformities and severe nasal obstruction...
October 5, 2016: Minerva Pediatrica
Jagdish Chander, Nidhi Singla, Mandeep Kaur, Rajpal Singh Punia, Ashok Attri, Ana Alastruey-Izquierdo, José F Cano-Lira, Alberto Miguel Stchigel, Josep Guarro
BACKGROUND: Saksenaea erythrospora is an emerging and recently described pathogenic fungus mainly causing invasive cutaneous infections. Globally, very few human cases, caused by S. erythrospora, have been reported. In India, among the genus Saksenaea, S. vasiformis was the only reported pathogenic species, until recently when a case of fungal rhinosinusitis was reported to be caused by S. erythrospora. We observed five human cases of necrotizing skin and soft tissue infections caused by S...
October 4, 2016: Infectious Diseases
Naseem Akhtar, Riaz A Khan
Skin cancer is among one of the most common human malignancies wide-spread world-over with mortality statistics rising continuously at an alarming rate. The increasing frequency of these malignancies has marked the need for adopting effective treatment plan coupled with better and site-specific delivery options for the desired therapeutic agent's availability at the affected site. The concurrent delivery approaches to cancerous tissues are under constant challenge and, as a result, are evolving and gaining advancements in terms of delivery modes, therapeutic agents and site-specificity of the therapeutics delivery...
September 30, 2016: Progress in Lipid Research
Xi Tian, Samuel B Warner, Kyle T Wagner, Joseph M Caster, Tian Zhang, Patricia Ohana, Alberto A Gabizon, Andrew Z Wang
PURPOSE: To examine the effect of radiation on in vitro drug activation and release of Promitil, a pegylated liposomal formulation of a mitomycin C (MMC) lipid-based prodrug; and examine the efficacy and toxicity of Promitil with concurrent radiation in colorectal cancer models. METHODS AND MATERIALS: Promitil was obtained from Lipomedix Pharmaceuticals (Jerusalem, Israel). We tested the effects of radiation on release of active MMC from Promitil in vitro. We next examined the radiosensitization effect of Promitil in vitro...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Kunat Suktham, Thongchai Koobkokkruad, Somsak Saesoo, Nattika Saengkrit, Suvimol Surassmo
Sericin protein (SP) is widely used as a nutrient biomaterial for biomedical and cosmeceutical applications although it shows low stability to heat and light. To overcome these problems and add value to wastewater from the silk industry, sericin protein was recovered as sericin-loaded copolymer-liposomes (SP-PVA-LP), prepared through thin film hydration. The size and morphology of the liposomes were investigated using dynamic light scattering (DLS), and electron microscopy (SEM and TEM). The particle size, liposome surface morphology and encapsulation efficiency of SP were dependent on PVA concentration...
September 21, 2016: Colloids and Surfaces. B, Biointerfaces
Paula Santos Nunes, Alessandra Silva Rabelo, Jamille Cristina Campos de Souza, Bruno Vasconcelos Santana, Thailson Monteiro Menezes da Silva, Mairim Russo Serafini, Paula Dos Passos Menezes, Bruno Dos Santos Lima, Juliana Cordeiro Cardoso, Júlio César Santana Alves, Luiza Abrahão Frank, Sílvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Malone Santos Pinheiro, Ricardo Luiz Cavalcanti de Albuquerque, Adriano Antunes de Souza Araújo
There are a range of products available which claim to accelerate the healing of burns; these include topical agents, interactive dressings and biomembranes. The aim of this study was to assess the effect of a gelatin-based membrane containing usnic acid/liposomes on the healing of burns in comparison to silver sulfadiazine ointment and duoDerme(®) dressing, as well as examining its quantification by high performance liquid chromatography. The quantification of the usnic acid/liposomes was examined using high performance liquid chromatography (HPLC) by performing separate in vitro studies of the efficiency of the biomembranes in terms of encapsulation, drug release and transdermal absorption...
September 12, 2016: International Journal of Pharmaceutics
Fangzhen Jiang, Kai Jin, Shenyu Huang, Qi Bao, Zheren Shao, Xueqing Hu, Juan Ye
Melanoma is one common skin cancer. In the present study, the potential anti-melanoma activity by a liposomal C6 ceramide was tested in vitro. We showed that the liposomal C6 (ceramide) was cytotoxic and anti-proliferative against a panel of human melanoma cell lines (SK-Mel2, WM-266.4 and A-375 and WM-115). In addition, liposomal C6 induced caspase-dependent apoptotic death in the melanoma cells. Reversely, its cytotoxicity was attenuated by several caspase inhibitors. Intriguingly, liposomal C6 was non-cytotoxic to B10BR mouse melanocytes and primary human melanocytes...
2016: PloS One
Mukul Ashtikar, Kalpa Nagarsekar, Alfred Fahr
Strong barrier properties of stratum corneum often limits the efficiency of drug delivery through skin. Several strategies were tried to improve permeation of drug through skin for local as well as systemic drug delivery. Incorporation of the drug within flexible liposomal vesicles has been one of the popular and well-studied approaches for delivering drug to deeper layers of the skin or even systemic circulation. Flexible/deformable/elastic liposomal systems such as invasomes, Transfersomes®, ethosomes, niosomes, etc...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Weihua Zhang, Yuanyuan Yang, Tao Lv, Zhaoyang Fan, Yongquan Xu, Junfeng Yin, Bingwu Liao, Hao Ying, Nagaiya Ravichandran, Qizhen Du
Nanoethosomal suspensions, composed of phospholipids, ethanol, and water, are novel lipid carriers. These suspensions have been reported to enhance the permeation of drugs into the skin as a result of the interdigitation effect of ethanol on the lipid bilayer of liposomes and by increasing the fluidity of lipids in the stratum corneum. The physical stability of the nanoethosomal suspension is still a critical research problem until now. This study investigated the commercial palm sucrose esters to improve the colloidal stability of nanoethosomal suspensions...
September 12, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Carla Caddeo, Amparo Nacher, Antonio Vassallo, Maria Francesca Armentano, Ramon Pons, Xavier Fernàndez-Busquets, Claudia Carbone, Donatella Valenti, Anna Maria Fadda, Maria Manconi
The present investigation reports the development of liposomes for the co-delivery of naturally occurring polyphenols, namely quercetin and resveratrol. Small, spherical, uni/bilamellar vesicles were produced, as demonstrated by light scattering, cryo-TEM, SAXS. The incorporation of quercetin and resveratrol in liposomes did not affect their intrinsic antioxidant activity, as DPPH radical was almost completely inhibited. The cellular uptake of the polyphenols was higher when they were formulated in liposomes, and especially when co-loaded rather than as single agents, which resulted in a superior ability to scavenge ROS in fibroblasts...
September 5, 2016: International Journal of Pharmaceutics
Md Habban Akhter, Saima Amin
Squamous cell carcinoma of skin has become an important matter of discussion worldwide due to high number of deaths. Treatment of such cancer involves use of drugs (chemotherapy) along with surgery or radiation therapy. The combination therapy is always preferred than single treatment modality due to poor internalization of most of the chemotherapeutics in the affected cells. Now a days, nanoparticle based drug delivery to squamous cell carcinoma is equanimous to become a leading therapeutic approach for cancer treatment...
September 6, 2016: Current Drug Delivery
Mei Shao, Zahid Hussain, Hnin Ei Thu, Shahzeb Khan, Haliza Katas, Tarek A Ahmed, Minaketan Tripathy, Jing Leng, Hua-Li Qin, Syed Nasir Abbas Bukhari
Atopic dermatitis (AD) is a chronically relapsing skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin-E (IgE), T-lymphocytes and mast cells. The key pathophysiological factors causing this disease are immunological disorders and the compromised epidermal barrier integrity. Pruritus, intense itching, psychological stress, deprived physical and mental performance and sleep disturbance are the hallmark features of this dermatological complication. Preventive interventions which include educational programs, avoidance of allergens, exclusive care towards skin, and the rational selection of therapeutic regimen play key roles in the treatment of dermatosis...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
Hui Zhang, Xuemin Zhu, Jingjing Shen, Haiheng Xu, Min Ma, Wei Gu, Qiudong Jiang, Jun Chen, Jinao Duan
A prerequisite for successful transdermal or dermal drug therapy is the drug ability to penetration through the skin, especially stratum corneum (SC). The most acceptable technique for measuring skin permeation in vitro is the application of both the Franz diffusion cell device and the skin model. As the skin model, a liposome-based artificial skin membrane (LASM) consisting of tight layers of liposomes immobilized on a filter was prepared and characterized. Using porcine ear skin, rat skin and Strat-M(TM) artificial membrane as control, the LASM was then evaluated in permeation studies with five active compounds, i...
August 31, 2016: Journal of Liposome Research
John W Sessions, David G Armstrong, Sandra Hope, Brian D Jensen
Traditional methods for addressing chronic wounds focus on correcting dysfunction by controlling extracellular elements. This review highlights technologies that take a different approach - enhancing chronic wound healing by genetic modification to wound beds. Featured cutaneous transduction/transfection methods include viral modalities (i.e. adenoviruses, adeno-associated viruses, retroviruses, and lentiviruses) and conventional non-viral modalities (i.e. naked DNA injections, micro-seeding, liposomal reagents, particle bombardment, and electroporation)...
August 30, 2016: Experimental Dermatology
Vieri Grandi, Irene Baldi, Pietro Cappugi, Moira Mori, Nicola Pimpinelli
BACKGROUND: Actinic Keratoses (AK) are considered a form of in situ Squamous Cell Carcinoma (SCC) arising on chronically photoexposed skin. PDT with ALA or MAL is an effective treatment for multiple AK due its high Overall Response Ratio (ORR) but is burdened by important drawbacks: time-consumption, pain and high costs. Indole-3 acetic acid (IAA) is a newly described photosensitizer with proven clinical efficacy on seborrheic dermatitis and acne vulgaris. The aim of the study was to assess efficacy, safety and tolerability of a cycle of IAA-PDT at 0...
August 23, 2016: Photodiagnosis and Photodynamic Therapy
Ming-Hsien Lin, Chi-Feng Hung, Ibrahim A Aljuffali, Calvin T Sung, Chi-Ting Huang, Jia-You Fang
A cationic amphiphile, soyaethyl morpholinium ethosulfate (SME), immobilized in liposomes or nanoemulsions, was prepared in an attempt to compare the antibacterial activity between SME intercalated in the phospholipid bilayer and oil-water interface. Before antibacterial assessment, the size of the liposomes and nanoemulsions was respectively recorded as 75 and 214nm. The data of minimum inhibitory concentration (MIC)/minimum bactericidal concentration (MBC) and live/dead cell count demonstrated a superior antimicrobial activity of nanoemulsions compared to liposomes against Staphylococcus aureus, methicillin-resistant S...
August 21, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Kevin Ita
In 2010, the number of deaths from infectious diseases globally was approximately 15 million. It has been reported that two-thirds of deaths from infections are caused by around 20 species, mainly bacteria and viruses. Transnational migration caused by war and the development of transportation facilities have led to the global spread of infectious diseases. Subcutaneous vaccination, though widespread, has a number of problems: the need for trained healthcare personnel, pain, needle-related injuries as well as storage difficulties...
August 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Alam Zeb, Omer Salman Qureshi, Hyung-Seo Kim, Ji-Hye Cha, Hoo-Seong Kim, Jin-Ki Kim
The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. The physicochemical properties of MTX-UDLs were determined in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. The deformability of MTX-UDLs was compared with that of methotrexate-entrapped conventional liposomes (MTX-CLs) using a steel pressure filter device...
2016: International Journal of Nanomedicine
Mihai Paduraru, Carlos Moreno-Sanz, Jose Maria Olalla Gallardo
Mucormycosis is most common in immunocompromised patients, but it can also occur in healthy hosts, most frequently as primary cutaneous mucormycosis (PCM) and predominantly as a result of skin trauma. We present an uncommon case of PCM in a healthy, young man with no previous history of local trauma. Despite rapid progression of the infection, the patient was successfully treated through surgical intervention and by administering liposomal amphotericin B and posaconazole. He made a full recovery without the need for skin grafting...
2016: BMJ Case Reports
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