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Liposomes and skin

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https://www.readbyqxmd.com/read/28631206/diclofenac-loaded-lipid-nanovesicles-prepared-by-double-solvent-displacement-for-skin-drug-delivery
#1
M Sala, F Locher, M Bonvallet, G Agusti, A Elaissari, H Fessi
PURPOSE: Herein, we detail a promising strategy of nanovesicle preparation based on control of phospholipid self-assembly: the Double Solvent Displacement. A systematic study was conducted and diclofenac as drug model encapsulated. In vitro skin studies were carried out to identify better formulation for dermal/transdermal delivery. METHODS: This method consists in two solvent displacements. The first one, made in a free water environment, has allowed triggering a phospholipid pre-organization...
June 19, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28625748/comparison-of-liposomal-drug-formulations-for-transdermal-iontophoretic-drug-delivery
#2
K Malinovskaja-Gomez, S Espuelas, M J Garrido, J Hirvonen, T Laaksonen
This study was aimed to evaluate the in vitro transdermal direct/pulsed current iontophoretic delivery of an amphiphilic model compound from various lipid vesicle-encapsulated formulations compared to free-drug formulation. Conventional, pegylated, ultradeformable liposomes (transfersomes) and ethosomes loaded with a negatively charged drug diclofenac sodium (DS) were prepared and characterized. All the liposomes possessed an average size of ≈100-150nm and negative zeta potential. No changes in colloidal stability were detected after 8h incubation of any vesicle formulation under constant or pulsed iontophoretic current...
June 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28609225/preparation-of-nano-cationic-liposome-as-carrier-membrane-for-polyhexamethylene-biguanide-chloride-through-various-methods-utilizing-higher-antibacterial-activities-with-low-cell-toxicity
#3
Elnaz Ahani, Majid Montazer, Tayebeh Toliyat, Mahnaz Mahmoudi Rad, Tina Harifi
This study suggested successful encapsulation of polyhexamethylene biguanide chloride (PHMB) into nano cationic liposome as a biocompatible antibacterial agent with less cytotoxicity and higher activities. Phosphatidylcholine, cholesterol and stearylamine were used to prepare nano cationic liposome using thin film hydration method along with sonication or homogeniser. Sonication was more effective in PHMB loaded nano cationic liposome preparation with smaller size (34 nm). FTIR, (1)H NMR and XRD analyses were used to confirm the encapsulation of PHMB into nano cationic liposome...
March 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28596489/nanobubbles-as-ultrasound-contrast-agent-for-facilitating-small-cell-lung-cancer-imaging
#4
Jin-Ping Wang, Xiao-Lin Zhou, Ji-Ping Yan, Rong-Qin Zheng, Wei Wang
BACKGROUND: This study is to investigate whether liposome-loaded nanobubbles (NBs) have the potentials to carry anti-pro-gastrin releasing peptide (proGRP) antibody and enhance ultrasound imaging of small cell lung cancer (SCLC). METHODS: NBs were loaded with an antibody against SCLC (H446 cell line). A nude mouse model of SCLC tumor was established by a subcutaneous injection of tumor cell suspension in the dorsal skin. Images for contrast-enhanced ultrasound (CEUS) of xenograft tumors in the model were obtained through an intravenous injection of blank and targeting NBs...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28578126/ultradeformable-liposome-loaded-with-zinc-phthalocyanine-and-ru-nh-nhq-tpy-no-3-for-photodynamic-therapy-by-topical-application
#5
Renata Galvão de Lima, Antonio Cláudio Tedesco, Roberto Santana da Silva, Margaret Jayne Lawrence
Ultradeformable liposomes (UDLs) as a drug delivery system (DDS), prepared from the unsaturated phospholipid, dioleylphosphocholine (DOPC), and containing the non-ionic surfactant Tween 20 as edge activator, have been explored as topical vehicles for zinc phthalocyanine (ZnPc) and the nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) (RuNO) as a photosensitizers for co-generation of (1)O2 and NO as reactive species, respectively. However, in order to ensure that ZnPc was present in the UDLs in its monomeric form - essential for maximal ZnPc photophysical properties - it was necessary to replace 40wt% of the DOPC with the saturated phospholipid, dimyristoylphosphocholine (DMPC)...
May 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28571554/methotrexate-in-the-treatment-of-psoriasis-and-rheumatoid-arthritis-mechanistic-insights-current-issues-and-novel-delivery-approaches
#6
P Rajitha, Raja Biswas, M Sabitha, R Jayakumar
Our review is focused on the use of methotrexate in drug therapy of two autoimmune diseases, psoriasis and rheumatoid arthritis (RA). The article describes the pathogenesis of psoriasis and RA, the role of methotrexate in the treatment of these diseases with more focused review on the mechanism behind the clinical benefits of methotrexate therapy. Methotrexate due to its cytotoxic, anti-inflammatory and immune modulatory activities provides clinical benefits in the therapy of the selected diseases. This review also gives a panorama of the problems associated with the use of methotrexate in the selected diseases and the guidelines provided by FDA for its safe use...
May 31, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28565781/design-and-implementation-of-fast-allergy-skin-test-detector-for-traditional-chinese-medicine-injections
#7
Ying Xiao, Yubin Zhao, Yanming Xie
Traditional Chinese medicine (TCM) injections are prepared from active substances extracted from TCMs and other natural medicines to establish scientific and technological methods, based on TCM hypotheses and experiences. A device was designed to provide a fast allergy skin test detector for TCM injections that could be applied to drugs of a single component or complex components. A novel fast allergy skin test detector for TCM injections was developed combining direct-current main, drug solution permeation devices of various shape that were compatible with the skin test electrode, nano-sponge patch adsorption, and flexible liposome coverage technologies with high-amplitude pulse...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28558705/disseminated-cryptococcosis-with-recurrent-multiple-abscesses-in-an-immunocompetent-patient-a-case-report-and-literature-review
#8
Qiaoling Ruan, Yimin Zhu, Shu Chen, Liping Zhu, Shu Zhang, Wenhong Zhang
BACKGROUND: Cryptococcus neoformans is frequently present as an opportunistic pathogen mainly affecting immunocompromised populations. Disseminated C. neoformans infection in immunocompetent population is rare and usually involves lung and central nerve system. Cryptococcus from biologic samples can easily grow on routine fungal and bacterial culture media. Besides, cryptococcal latex agglutination test has been established as a reliable diagnostic tool with overall sensitivities of 93-100%...
May 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28552724/nano-liposomal-entrapment-of-bioactive-peptidic-fraction-from-fish-gelatin-hydrolysate
#9
Seyed Fakhreddin Hosseini, Leila Ramezanzade, Maryam Nikkhah
This study guided the potential of nanoliposomal vesicles for the encapsulation of an active peptidic fraction from the fish skin gelatin by enzymatic hydrolysis using alcalase. The average particle size of peptide-loaded nanoliposomes was found to be in the range 134-621nm, with a ζ-potential of 0.06-8.65mV and a polydispersity index of 0.27-0.49, when the initial peptide content was 0-10mg/ml. The FTIR analysis showed that there was an effective hydrophobic interaction as well as hydrogen bonding between phosphatidylcholine and peptidic fraction...
May 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28551229/biopolymer-coated-nanoliposomes-as-carriers-of-rainbow-trout-skin-derived-antioxidant-peptides
#10
Leila Ramezanzade, Seyed Fakhreddin Hosseini, Maryam Nikkhah
In this study, an antioxidant peptide fraction with a molecular mass<30kDa (PF30) isolated from rainbow trout (Oncorhynchus mykiss) skin gelatin hydrolysates was encapsulated in chitosan-coated nanoliposomes. The mean particle size of liposomal nanovesicles containing PF30 was found to be in the range 163.4-234nm with a low polydispersity index (PDI<0.5); furthermore, the ζ-potential changed from +3.9mV in uncoated liposomes to +45.5mV in biopolymer-coated liposomes. FTIR spectra showed electrostatic interactions as well as hydrogen bonding between phospholipid head groups and amine groups of chitosan...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28544386/skin-mucous-membrane-disorder-and-therapeutic-effect-of-pegylated-liposomal-doxorubicin-in-recurrent-ovarian-cancer
#11
Yuki Yamada, Ryuji Kawaguchi, Fuminori Ito, Kana Iwai, Emiko Niiro, Hiroshi Shigetomi, Yasuhito Tanase, Hiroshi Kobayashi
AIM: Hand-foot syndrome (HFS) induced by chemotherapy and molecule-targeting drugs is correlated with treatment efficacy. We conducted a retrospective analysis to evaluate the relationship between HFS and efficacy of pegylated liposomal doxorubicin (PLD) for recurrent ovarian cancer. METHODS: Patients were treated with PLD between July 2009 and May 2014. We evaluated patient characteristics, incidence of adverse events, clinical benefit (rate of complete response, partial response, and stable disease), progression-free survival, and overall survival...
May 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28523894/primary-cutaneous-mucormycosis-in-an-extremely-preterm-infant-successfully-treated-with-liposomal-amphotericin-b
#12
Christopher D Lowe, Rebecca J Sainato, David R Stagliano, Maribel M Morgan, Brian P Green
Cutaneous mucormycosis is a rare but often fatal invasive fungal infection that occurs most commonly in patients with diabetes, malignancy, and other immunocompromising conditions. We report an extremely preterm (<28 weeks) baby boy who developed polymicrobial sepsis and primary cutaneous mucormycosis within his first 10 days of life. He was successfully treated with medical management alone since he was not a candidate for surgery. Successful treatment of cutaneous mucormycosis without surgical debridement has been reported on only two other occasions...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28522423/sertaconazole-nitrate-loaded-nanovesicular-systems-for-targeting-skin-fungal-infection-in-vitro-ex-vivo-and-in-vivo-evaluation
#13
Menna M Abdellatif, Islam A Khalil, Mahmoud A F Khalil
The aim of this study was to develop different vesicular systems for sertaconazole nitrate and evaluate the ability of targeting deep skin layers to treat dermal fungal infection. Therefore, different phospholipid based nanovesicles, namely liposomes, glycerosomes, transferosmes and ethosomes were prepared and in-vitro evaluated for morphology, entrapment efficiency, vesicle size and zeta potential value, followed by ex-vivo evaluation through skin penetration and permeation. The selected vesicular formula was incorporated into gel base system and assessed by ex-vivo permeation visualization study using confocal laser scanning microscopy (CLSM)...
May 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28506801/old-drug-new-wrapping-a-possible-comeback-for-chloramphenicol
#14
Sveinung G Ingebrigtsen, Alena Didriksen, Mona Johannessen, Nataša Škalko-Basnet, Ann Mari Holsæter
The antimicrobial drug chloramphenicol (CAM) exhibits activity against resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). However, its use has been limited due to its toxicity. As the threat of antibiotic resistance continues to grow, a promising approach might be to increase the use of historical antimicrobial agents that demonstrate clinical efficacy, but are hampered by toxicity. We therefore aimed to prepare a liposome-in-hydrogel system for dermal delivery of CAM. Chitosan (CS) was used as the hydrogel vehicle due to its antimicrobial activity and excellent biocompatibility...
May 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28503066/essential-oil-mediated-glycerosomes-increase-transdermal-paeoniflorin-delivery-optimization-characterization-and-evaluation-in-vitro-and-in-vivo
#15
Kai Zhang, Yongtai Zhang, Zhe Li, Nana Li, Nianping Feng
In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490875/mechanism-of-transdermal-permeation-promotion-of-lipophilic-drugs-by-ethosomes
#16
Li Yang, Lifang Wu, Dongze Wu, Deshun Shi, Tai Wang, Xiaoliang Zhu
Ethosomes can promote the penetration of lipophilic drugs into the skin, but the underlying mechanism is still unknown. The purpose of this study was to investigate the mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes. The formulation of ethosomes was optimized using the Box-Behnken experimental design, in which Rhodamine B and 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphocholine were used to simulate a model lipophilic drug and act as a fluorescent tracer of ethosomal phospholipids, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28481795/the-use-of-fdg-pet-ct-imaging-for-the-assessment-of-early-antifungal-treatment-response-in-disseminated-fusariosis
#17
Romain-David Seban, Gérald Bonardel, Mohamed Guernou, David Lussato, Mathieu Queneau
Fusariosis is an opportunistic infection, caused by a filamentous fungus, found on plants and in soil. The treatment of disseminated pattern, seen in immunocompromised patients with severe neutropenia, is difficult because of antifungal therapy resistance. A 12-year-old girl, who was diagnosed with B-cell acute lymphoblastic leukemia, developed multiple widespread skin papules and subcutaneous nodules, at day 20 of consolidation therapy. Histological examination with cultures of skin tissue revealed Fusarium species...
July 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28476587/preparation-and-in-vivo-evaluation-of-cationic-elastic-liposomes-comprising-highly-skin-permeable-growth-factors-combined-with-hyaluronic-acid-for-enhanced-diabetic-wound-healing-therapy
#18
Jeong Uk Choi, Seong Wook Lee, Rudra Pangeni, Youngro Byun, In-Soo Yoon, Jin Woo Park
To enhance the therapeutic effects of exogenous administration of growth factors (GFs) in the treatment of chronic wounds, we constructed GF combinations of highly skin-permeable epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and platelet-derived growth factor-A (PDGF-A). We genetically conjugated a low-molecular-weight protamine (LMWP) to the N-termini of these GFs to form LMWP-EGF, LMWP-IGF-I, and LMWP-PDGF-A. Subsequently, these molecules were complexed with hyaluronic acid (HA). Combinations of native or LMWP-fused GFs significantly promoted fibroblast proliferation and the synthesis of procollagen, with a magnification of these results observed after the GFs were complexed with HA...
May 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28472915/nanotechnology-a-promising-tool-towards-wound-healing
#19
Thaís Alberti, Daniela S Coelho, Ana Voytena, Heloísa Pitz, Manuel de Prá, Letícia Mazzarino, Shirley Kuhnen, Rosa Maria Ribeiro-do-Valle, Marcelo Maraschin, Beatriz Veleirinho
Nanotechnology is an exciting emerging field with multiple applications in skin regeneration. Nanofibers have gained special attention in skin regeneration based on their structural similarity to the extracellular matrix. A wide variety of polymeric nanofibers with distinct properties have been developed and tested as scaffolds for skin regeneration. Besides providing support for tissue repair, nanofibrous materials can act as delivery systems for drugs, proteins, growth factors, and other molecules. Moreover, the morphology, biodegradability, and other functionalities of nanofibrous materials can be controlled towards specific conditions of wound healing...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28444443/-new-approaches-for-the-prevention-of-actinic-keratosis
#20
REVIEW
H Stege, J Krutmann
Actinic keratosis is one of the most common skin diseases. Because of the ongoing demographic changes, it is anticipated that the incidence will further increase. Prevention of actinic keratoses is thus of great importance. By far the most important cause of actinic keratoses is the chronic cumulative irradiation of human skin with ultraviolet B and A radiation from natural sunlight. There is no doubt that use of sunscreens is effective in preventing actinic keratoses. Recent studies indicate that in high-risk groups the regular use of medical devices which are characterized by a very high SPF and which contain liposomally encapsulated DNA repair enzymes are effective in preventing the development of new actinic keratoses even when field cancerization is already present in human skin...
May 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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