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Liposomes and skin

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https://www.readbyqxmd.com/read/28725673/efficiency-data-of-intracellular-recombinant-protein-delivery-using-cationic-lipid-coated-silk-fibroin-particle
#1
Woo-Jin Kim, Bong-Soo Kim, Young-Dan Cho, Won-Joon Yoon, Jeong-Hwa Baek, Kyung-Mi Woo, Hyun-Mo Ryoo
This article presents data related to the research article "Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery" and focuses on the delivery efficiency aspects of the fibroin particle-cationic lipid complex (Fibroplex), including its fabrication and the intracellular delivery to the mouse skin tissue. We introduced a stable lipid-particle complex called "Fibroplex", formed by loading cargo protein onto a silk fibroin spherical particle core complexed with cationic liposomes to address the intracellular recombinant protein delivery...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28716129/current-knowledge-on-feline-injection-site-sarcoma-treatment
#2
REVIEW
Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Roman Lechowski
Feline injection-site sarcomas (FISS) are malignant skin tumours of mesenchymal origin, the treatment of which is a challenge for veterinary surgeons. The role of surgery, radiotherapy and chemotherapy in FISS treatment has been studied, and a correlation between "clean" surgical margins and disease-free survival has been shown. In addition, clean surgical margins are one of the most important factors for achieving a low recurrence rate. The most effective method of FISS treatment includes combining radical surgery with pre- or postoperative radiotherapy...
July 17, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28707264/evaluation-of-propylene-glycol-nanoliposomes-containing-curcumin-on-burn-wound-model-in-rat-biocompatibility-wound-healing-and-anti-bacterial-effects
#3
Nooshin Kianvash, Abbas Bahador, Maryam Pourhajibagher, Homanaz Ghafari, Vahid Nikoui, Sayed Mehdi Rezayat, Ahmad Reza Dehpour, Alireza Partoazar
Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28698667/phylogenetic-analysis-reveals-two-genotypes-of-the-emerging-fungus-mucor-indicus-an-opportunistic-human-pathogen-in-immunocompromised-patients
#4
Saad J Taj-Aldeen, Muna Almaslamani, Bart Theelen, Teun Boekhout
Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28697465/combined-photodynamic-and-antibiotic-therapy-for-skin-disorder-via-lipase-sensitive-liposomes-with-enhanced-antimicrobial-performance
#5
Songhee Jeong, Jonghwan Lee, Byeong Nam Im, Hyung Park, Kun Na
A lipase-sensitive singlet oxygen-producible and erythromycin-loaded liposome (LSSPL) was developed for combination antibacterial therapy for skin disorder. The LSSPL was synthesized by coating pullulan-pheophorbide a (PU-Pheo A) conjugates onto erythromycin-loaded liposomes composed of 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) and cholesterol. Lipase activity was chosen as the environmental-stimulus for the controlled release of erythromycin and Pheo A from LSSPL because skin inflammation-inducing Propionibacterium acnes (P...
July 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28689988/tip-enhanced-raman-scattering-for-tracking-of-invasomes-in-the-stratum-corneum
#6
Mukul Ashtikar, Lucas Langelüddecke, Alfred Fahr, Volker Deckert
Stratum corneum is the primary skin barrier to percutaneous absorption. Since 1980, topical liposomal formulations have been proposed and successfully employed for increasing the drug penetration through the skin. There is no clear consensus on the drug penetration mechanism from topically applied liposomes, despite a vast amount of research. One of the reasons for the ambiguity is that the interactions between the stratum corneum and liposomes are in nanoscale, which makes them difficult to probe. In this study, we employed tip-enhanced Raman scattering (TERS) to gain a better understanding of the interactions between the human stratum corneum and topically applied liposomal system called invasomes...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28662900/revisiting-the-use-of-spla2-sensitive-liposomes-in-cancer-therapy
#7
Houman Pourhassan, Gael Clergeaud, Anders E Hansen, Ragnhild G Østrem, Frederikke P Fliedner, Fredrik Melander, Ole L Nielsen, Ciara K O'Sullivan, Andreas Kjær, Thomas L Andresen
The first developed secretory phospholipase A2 (sPLA2) sensitive liposomal cisplatin formulation (LiPlaCis®) is currently undergoing clinical evaluation. In the present study we revisit and evaluate critical preclinical parameters important for the therapeutic potential and safety of platinum drugs, here oxaliplatin (L-OHP), formulated in sPLA2 sensitive liposomes. We show the mole percentage of negatively charged phospholipid needed to obtain enzyme-sensitivity for saturated systems is ≥25% for 16-carbon chain lipid membranes, and >40% for 18-chain lipid membranes, which was surprising as 25% is used clinically in LiPlaCis®...
June 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28653108/prevention-of-palmoplantar-erythrodysesthesia-in-patients-treated-with-pegylated-liposomal-doxorubicin-caelyx%C3%A2
#8
S Jung, J Sehouli, R Chekerov, F Kluschke, A Patzelt, H Fuss, F Knorr, J Lademann
PURPOSE: Palmoplantar erythrodysesthesia (PPE) is one of the most frequent side effects during systemic treatment with pegylated liposomal doxorubicin (PLD, Caelyx®). PPE lesions show a range of symptoms, from numbness to painful erosions, and can have a major impact on the quality of life in affected patients. Previously, a possible pathomechanism of PPE was found in doxorubicin-treated patients based on radical formation in the skin. Here, a preventive strategy using a topically applied ointment with a high radical protection factor was investigated...
June 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28639178/effective-skin-cancer-treatment-by-topical-co-delivery-of-curcumin-and-stat3-sirna-using-cationic-liposomes
#9
Anup Jose, Suman Labala, Kunal Manoj Ninave, Sudeep Kumar Gade, Venkata Vamsi Krishna Venuganti
The aim of the present study was to evaluate the effectiveness of iontophoretic co-delivery of curcumin and anti-STAT3 siRNA using cationic liposomes against skin cancer. Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA. This nanocomplex was characterized for the average particle size, zeta-potential, and encapsulation efficiency. The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p < 0...
June 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28631206/diclofenac-loaded-lipid-nanovesicles-prepared-by-double-solvent-displacement-for-skin-drug-delivery
#10
M Sala, F Locher, M Bonvallet, G Agusti, A Elaissari, H Fessi
PURPOSE: Herein, we detail a promising strategy of nanovesicle preparation based on control of phospholipid self-assembly: the Double Solvent Displacement. A systematic study was conducted and diclofenac as drug model encapsulated. In vitro skin studies were carried out to identify better formulation for dermal/transdermal delivery. METHODS: This method consists in two solvent displacements. The first one, made in a free water environment, has allowed triggering a phospholipid pre-organization...
June 19, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28625748/comparison-of-liposomal-drug-formulations-for-transdermal-iontophoretic-drug-delivery
#11
K Malinovskaja-Gomez, S Espuelas, M J Garrido, J Hirvonen, T Laaksonen
This study was aimed to evaluate the in vitro transdermal direct/pulsed current iontophoretic delivery of an amphiphilic model compound from various lipid vesicle-encapsulated formulations compared to free-drug formulation. Conventional, pegylated, ultradeformable liposomes (transfersomes) and ethosomes loaded with a negatively charged drug diclofenac sodium (DS) were prepared and characterized. All the liposomes possessed an average size of ≈100-150nm and negative zeta potential. No changes in colloidal stability were detected after 8h incubation of any vesicle formulation under constant or pulsed iontophoretic current...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28609225/preparation-of-nano-cationic-liposome-as-carrier-membrane-for-polyhexamethylene-biguanide-chloride-through-various-methods-utilizing-higher-antibacterial-activities-with-low-cell-toxicity
#12
Elnaz Ahani, Majid Montazer, Tayebeh Toliyat, Mahnaz Mahmoudi Rad, Tina Harifi
This study suggested successful encapsulation of polyhexamethylene biguanide chloride (PHMB) into nano cationic liposome as a biocompatible antibacterial agent with less cytotoxicity and higher activities. Phosphatidylcholine, cholesterol and stearylamine were used to prepare nano cationic liposome using thin film hydration method along with sonication or homogeniser. Sonication was more effective in PHMB loaded nano cationic liposome preparation with smaller size (34 nm). FTIR, (1)H NMR and XRD analyses were used to confirm the encapsulation of PHMB into nano cationic liposome...
March 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28596489/nanobubbles-as-ultrasound-contrast-agent-for-facilitating-small-cell-lung-cancer-imaging
#13
Jin-Ping Wang, Xiao-Lin Zhou, Ji-Ping Yan, Rong-Qin Zheng, Wei Wang
BACKGROUND: This study is to investigate whether liposome-loaded nanobubbles (NBs) have the potentials to carry anti-pro-gastrin releasing peptide (proGRP) antibody and enhance ultrasound imaging of small cell lung cancer (SCLC). METHODS: NBs were loaded with an antibody against SCLC (H446 cell line). A nude mouse model of SCLC tumor was established by a subcutaneous injection of tumor cell suspension in the dorsal skin. Images for contrast-enhanced ultrasound (CEUS) of xenograft tumors in the model were obtained through an intravenous injection of blank and targeting NBs...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28578126/ultradeformable-liposome-loaded-with-zinc-phthalocyanine-and-ru-nh-nhq-tpy-no-3-for-photodynamic-therapy-by-topical-application
#14
Renata Galvão de Lima, Antonio Cláudio Tedesco, Roberto Santana da Silva, Margaret Jayne Lawrence
Ultradeformable liposomes (UDLs) as a drug delivery system (DDS), prepared from the unsaturated phospholipid, dioleylphosphocholine (DOPC), and containing the non-ionic surfactant Tween 20 as edge activator, have been explored as topical vehicles for zinc phthalocyanine (ZnPc) and the nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) (RuNO) as a photosensitizers for co-generation of (1)O2 and NO as reactive species, respectively. However, in order to ensure that ZnPc was present in the UDLs in its monomeric form - essential for maximal ZnPc photophysical properties - it was necessary to replace 40wt% of the DOPC with the saturated phospholipid, dimyristoylphosphocholine (DMPC)...
May 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28571554/methotrexate-in-the-treatment-of-psoriasis-and-rheumatoid-arthritis-mechanistic-insights-current-issues-and-novel-delivery-approaches
#15
P Rajitha, Raja Biswas, M Sabitha, R Jayakumar
Our review is focused on the use of methotrexate in drug therapy of two autoimmune diseases, psoriasis and rheumatoid arthritis (RA). The article describes the pathogenesis of psoriasis and RA, the role of methotrexate in the treatment of these diseases with more focused review on the mechanism behind the clinical benefits of methotrexate therapy. Methotrexate due to its cytotoxic, anti-inflammatory and immune modulatory activities provides clinical benefits in the therapy of the selected diseases. This review also gives a panorama of the problems associated with the use of methotrexate in the selected diseases and the guidelines provided by FDA for its safe use...
May 31, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28565781/design-and-implementation-of-fast-allergy-skin-test-detector-for-traditional-chinese-medicine-injections
#16
Ying Xiao, Yubin Zhao, Yanming Xie
Traditional Chinese medicine (TCM) injections are prepared from active substances extracted from TCMs and other natural medicines to establish scientific and technological methods, based on TCM hypotheses and experiences. A device was designed to provide a fast allergy skin test detector for TCM injections that could be applied to drugs of a single component or complex components. A novel fast allergy skin test detector for TCM injections was developed combining direct-current main, drug solution permeation devices of various shape that were compatible with the skin test electrode, nano-sponge patch adsorption, and flexible liposome coverage technologies with high-amplitude pulse...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28558705/disseminated-cryptococcosis-with-recurrent-multiple-abscesses-in-an-immunocompetent-patient-a-case-report-and-literature-review
#17
Qiaoling Ruan, Yimin Zhu, Shu Chen, Liping Zhu, Shu Zhang, Wenhong Zhang
BACKGROUND: Cryptococcus neoformans is frequently present as an opportunistic pathogen mainly affecting immunocompromised populations. Disseminated C. neoformans infection in immunocompetent population is rare and usually involves lung and central nerve system. Cryptococcus from biologic samples can easily grow on routine fungal and bacterial culture media. Besides, cryptococcal latex agglutination test has been established as a reliable diagnostic tool with overall sensitivities of 93-100%...
May 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28552724/nano-liposomal-entrapment-of-bioactive-peptidic-fraction-from-fish-gelatin-hydrolysate
#18
Seyed Fakhreddin Hosseini, Leila Ramezanzade, Maryam Nikkhah
This study guided the potential of nanoliposomal vesicles for the encapsulation of an active peptidic fraction from the fish skin gelatin by enzymatic hydrolysis using alcalase. The average particle size of peptide-loaded nanoliposomes was found to be in the range 134-621nm, with a ζ-potential of 0.06-8.65mV and a polydispersity index of 0.27-0.49, when the initial peptide content was 0-10mg/ml. The FTIR analysis showed that there was an effective hydrophobic interaction as well as hydrogen bonding between phosphatidylcholine and peptidic fraction...
May 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28551229/biopolymer-coated-nanoliposomes-as-carriers-of-rainbow-trout-skin-derived-antioxidant-peptides
#19
Leila Ramezanzade, Seyed Fakhreddin Hosseini, Maryam Nikkhah
In this study, an antioxidant peptide fraction with a molecular mass<30kDa (PF30) isolated from rainbow trout (Oncorhynchus mykiss) skin gelatin hydrolysates was encapsulated in chitosan-coated nanoliposomes. The mean particle size of liposomal nanovesicles containing PF30 was found to be in the range 163.4-234nm with a low polydispersity index (PDI<0.5); furthermore, the ζ-potential changed from +3.9mV in uncoated liposomes to +45.5mV in biopolymer-coated liposomes. FTIR spectra showed electrostatic interactions as well as hydrogen bonding between phospholipid head groups and amine groups of chitosan...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28544386/skin-mucous-membrane-disorder-and-therapeutic-effect-of-pegylated-liposomal-doxorubicin-in-recurrent-ovarian-cancer
#20
Yuki Yamada, Ryuji Kawaguchi, Fuminori Ito, Kana Iwai, Emiko Niiro, Hiroshi Shigetomi, Yasuhito Tanase, Hiroshi Kobayashi
AIM: Hand-foot syndrome (HFS) induced by chemotherapy and molecule-targeting drugs is correlated with treatment efficacy. We conducted a retrospective analysis to evaluate the relationship between HFS and efficacy of pegylated liposomal doxorubicin (PLD) for recurrent ovarian cancer. METHODS: Patients were treated with PLD between July 2009 and May 2014. We evaluated patient characteristics, incidence of adverse events, clinical benefit (rate of complete response, partial response, and stable disease), progression-free survival, and overall survival...
May 19, 2017: Journal of Obstetrics and Gynaecology Research
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