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Liposomes and skin

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https://www.readbyqxmd.com/read/28820697/case-report-treatment-of-widespread-nodular-post-kala-azar-dermal-leishmaniasis-with-extended-dose-liposomal-amphotericin-b-in-bangladesh-a-series-of-four-cases
#1
Ariful Basher, Shomik Maruf, Proggananda Nath, Md Golam Hasnain, Muhammod Abdul Mukit, Azim Anuwarul, Fatima Aktar, Rupen Nath, Afm Akhtar Hossain, Abul Hasnat Milton, Dinesh Mondal, Abul Khair Mohammad Sumsuzzaman, Ridwanur Rahman, Mohammad Abul Faiz
Post kala-azar dermal leishmaniasis (PKDL) is a skin manifestation which usually appears after visceral leishmaniasis. It is now proved that PKDL patients serve as a reservoir for anthropometric leishmanial transmission. Hence, to achieve the kala-azar elimination target set by the World Health Organization in the Indian Subcontinent, PKDL cases should be given priority. The goal of treatment for PKDL should be early reepithelizlization and rapid cure, but unfortunately this has been difficult to achieve, especially for patients with severe lesions...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28807666/microrna-132-with-therapeutic-potential-in-chronic-wounds
#2
Xi Li, Dongqing Li, Aoxue Wang, Tongbin Chu, Warangkana Lohcharoenkal, Xiaowei Zheng, Jacob Grünler, Sampath Narayanan, Sofie Eliasson, Eva K Herter, Yang Wang, Yannan Ma, Marcus Ehrström, Liv Eidsmo, Maria Kasper, Andor Pivarcsi, Enikö Sonkoly, Sergiu-Bogdan Catrina, Mona Ståhle, Ning Xu Landén
Chronic wounds represent a major and rising health and economic burden worldwide. There is a continued search towards more effective wound therapy. We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared to normal skin wounds, and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared to wild-type mice. Local replenishment of miR-132 in the wounds of db/db mice accelerated wound closure effectively, which was accompanied by increased proliferation of wound-edge keratinocytes and reduced inflammation...
August 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28804723/ethosomes-of-phenylethyl-resorcinol-as-vesicular-delivery-system-for-skin-lightening-applications
#3
Tunyaluk Limsuwan, Prapaporn Boonme, Pasarat Khongkow, Thanaporn Amnuaikit
Ethosome formulations containing phenylethyl resorcinol (PR) were developed. The formulation was produced from 0.5% w/v PR, 0.5% w/v cholesterol from lanolin, 3% w/v L-α-phosphatidylcholine from soybean, 30% v/v absolute ethanol, and water up to 100% v/v. It was characterized by a vesicular size of 389 nm, low polydispersity index of 0.266, zeta potential of -34.19 ± 0.44 mV, high PR entrapment efficiency of 71%, and good stability on storage at 4 and 30°C at 75% RH for 4 months. In vitro studies using pig skin revealed that permeation coefficient of PR from ethosomes was significantly higher than that from liposomes...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28800544/protease-loaded-permeation-enhancer-liposomes-for-treatment-of-skin-fibrosis-arisen-from-second-degree-burn
#4
Kamini Sahu, Monika Kaurav, Ravi Shankar Pandey
Cysteine protease (papain) is a plant derived enzyme and due to its collagenolytic activity has potential in fibrosis reduction. However, a major hurdle in its use as fibrosis reducing agent is to overcome stratum corneum skin barrier via topical application, owing to its hydrophilic and high molecular weight and protein nature which is prone to degradation. The aim of the present study was to develop a penetration enhancer incorporated drug delivery system, i.e. propylene glycol (PG) liposomes, loaded with papain for application in fibrosis therapy...
August 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28794452/the-anti-influenza-m2e-antibody-response-is-promoted-by-xcr1-targeting-in-pig-skin
#5
Charlotte Deloizy, Even Fossum, Christophe Barnier-Quer, Céline Urien, Tiphany Chrun, Audrey Duval, Maelle Codjovi, Edwige Bouguyon, Pauline Maisonnasse, Pierre-Louis Hervé, Céline Barc, Olivier Boulesteix, Jérémy Pezant, Christophe Chevalier, Nicolas Collin, Marc Dalod, Bjarne Bogen, Nicolas Bertho, Isabelle Schwartz-Cornil
XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from experimental models to human and veterinary applications. Here we evaluated in pigs the immunogenicity of bivalent protein structures made of XCL1 fused to the external portion of the influenza virus M2 proton pump, which is conserved through strains and a candidate for universal influenza vaccines...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770285/-treatment-of-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#6
REVIEW
J P Nicolay, C Assaf
Adequate therapeutic management of cutaneous T-cell lymphoma (CTCL) requires the identification of the exact CTCL stage and entity within the current WHO classification. There is no curative therapy for CTCL yet, so that treatment currently aims at improving symptoms and quality of life as well as reducing relapse rates. The treatment has to be stage-adapted. Therapeutic options comprise skin-directed as well as systemic treatment. In early stages, phototherapy and local steroids are the first-line therapeutic options...
August 2, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28768951/characterization-and-evaluation-of-skin-permeation-of-tocopheryl-phosphoric-acid-loaded-phospholipid-nanoparticles
#7
Tomonobu Uchino, Yasunori Miyazaki, Ako Fujii, Yoshiyuki Kagawa
 Tocopheryl phosphoric acid (TPA, a hydrophilic vitamin E derivative) loaded liposome and glycerin containing phospholipid nanoparticles (GPLNP) were prepared using the film rehydration and extrusion method. Nanoparticle formulations were evaluated for size, zeta potential, and in vitro permeation across hairless mouse skin, and (31)P NMR spectral analysis was performed. The prepared formulations were stable for 2 weeks, and their mean nanoparticle size varied between 90 and 140 nm. Although glycerin did not affect the particle size of the empty (no TPA) system, TPA-loading resulted in the reduction of particle size and conferred a negative charge...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28768931/potential-of-stratum-corneum-lipid-liposomes-for-screening-of-chemical-skin-penetration-enhancers
#8
Pajaree Sakdiset, Hiroaki Todo, Kenji Sugibayashi
The evaluation of effective skin chemical penetration enhancers (CPEs) is a crucial process in the development of transdermal and dermal formulations with the capacity to overcome the stratum corneum barrier. In the present study, we aimed to investigate the potential of stratum corneum lipid liposomes (SCLLs) as an alternative tool for the screening of various types and concentrations of CPEs. SCLLs were prepared using a thin-film hydration technique, and two types of fluorescent probes (sodium fluorescein [FL] or 1,6-diphenyl-1,3,5-hexatriene [DPH] were entrapped separately into SCLLs (FL-SCLL and DPH-SCLL, respectively)...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28768499/simultaneous-primary-invasive-cutaneous-aspergillosis-in-two-preterm-twins-case-report-and-review-of-the-literature
#9
Floriane Gallais, Julie Denis, Olfa Koobar, Laurence Dillenseger, Dominique Astruc, Raoul Herbrecht, Ermanno Candolfi, Valérie Letscher-Bru, Marcela Sabou
BACKGROUND: Primary invasive cutaneous aspergillosis is a rare fungal infection that occurs mostly in immunocompromised patients. Newborns of very low birth weight present a high risk for this type of infection due to an immaturity of the cutaneous barrier and of the immune system. CASE PRESENTATION: We describe here a case of simultaneous invasive cutaneous aspergillosis in two preterm twins. Two male preterm bichorionic biamniotic twins (A & B) were born at a general hospital by spontaneous normal delivery at 24 weeks and 6 days of gestation...
August 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28761343/elastic-liposomes-as-novel-carriers-recent-advances-in-drug-delivery
#10
REVIEW
Afzal Hussain, Sima Singh, Dinesh Sharma, Thomas J Webster, Kausar Shafaat, Abdul Faruk
Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral routes for efficient and effective drug delivery. Increased drug encapsulation efficiency, enhanced drug permeation and penetration into or across the skin, and ultradeformability have led to widespread interest in ELs to modulate drug release, permeation, and drug action more efficiently than conventional drug-release vehicles...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28756612/clinical-pharmacokinetics-of-systemically-administered-antileishmanial-drugs
#11
REVIEW
Anke E Kip, Jan H M Schellens, Jos H Beijnen, Thomas P C Dorlo
This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and excretion and potential drug-drug interactions. This overview provides an understanding of their clinical pharmacokinetics, which could assist in rationalising and optimising treatment regimens, especially in combining multiple antileishmanial drugs in an attempt to increase efficacy and shorten treatment duration...
July 29, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28753523/development-and-in-vitro-assessment-of-psoralen-and-resveratrol-co-loaded-ultradeformable-liposomes-for-the-treatment-of-vitiligo
#12
Sindhu Doppalapudi, Shaheen Mahira, Wahid Khan
Vitiligo is a de-pigmenting skin disorder characterized by white patches on skin due to partial or complete loss of melanocytes. Psoralen in combination with ultraviolet-A (PUVA) acts by stimulation of melanin content and tyrosinase activity in melanocytes. Resveratrol, a sirtuin activator and a potential anti-oxidant reduce oxidative stress which is one of the triggering factors for initiation of vitiligo. Despite their therapeutic activity, weak percutaneous permeability of psoralen and poor solubility of resveratrol hinders their effective topical administration...
July 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28744121/design-optimization-and-characterization-of-coenzyme-q10-and-d-panthenyl-triacetate-loaded-liposomes
#13
Burak Çelik, Ali Asram Sağıroğlu, Samet Özdemir
Coenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28740383/enhanced-immunization-via-dissolving-microneedle-array-based-delivery-system-incorporating-subunit-vaccine-and-saponin-adjuvant
#14
Ji-Hui Zhao, Qi-Bo Zhang, Bao Liu, Xiang-Hua Piao, Yu-Lu Yan, Xiao-Ge Hu, Kuan Zhou, Yong-Tai Zhang, Nian-Ping Feng
PURPOSE: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS: OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxicity to mouse bone marrow dendritic cells (BMDCs), and hemolytic activity to rabbit red blood cells (RBCs) were evaluated...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28738502/formulation-and-optimization-of-lacidipine-loaded-niosomal-gel-for-transdermal-delivery-in-vitro-characterization-and-in-vivo-activity
#15
Mohd Qumbar, Ameeduzzafar, Syed Sarim Imam, Javed Ali, Javed Ahmad, Asgar Ali
The aim of the present research work is to formulate lacidipine (LAC) loaded niosomes formulation for the management of hypertension by thin film hydration technique. The developed formulations were statistically optimized by four factors, three levels Box-Behnken design and were evaluated for vesicle size, entrapment efficiency, and flux. The optimized LAC niosomes was further evaluated for permeation depth by confocal laser scanning microscopy (CLSM) and converted to gel formulation. Further, the optimized LAC niosomes gel was evaluated for ex-vivo permeation study, skin irritation study, stability study and pharmacodynamics study...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28725673/efficiency-data-of-intracellular-recombinant-protein-delivery-using-cationic-lipid-coated-silk-fibroin-particle
#16
Woo-Jin Kim, Bong-Soo Kim, Young-Dan Cho, Won-Joon Yoon, Jeong-Hwa Baek, Kyung-Mi Woo, Hyun-Mo Ryoo
This article presents data related to the research article "Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery" and focuses on the delivery efficiency aspects of the fibroin particle-cationic lipid complex (Fibroplex), including its fabrication and the intracellular delivery to the mouse skin tissue. We introduced a stable lipid-particle complex called "Fibroplex", formed by loading cargo protein onto a silk fibroin spherical particle core complexed with cationic liposomes to address the intracellular recombinant protein delivery...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28716129/current-knowledge-on-feline-injection-site-sarcoma-treatment
#17
REVIEW
Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Roman Lechowski
Feline injection-site sarcomas (FISS) are malignant skin tumours of mesenchymal origin, the treatment of which is a challenge for veterinary surgeons. The role of surgery, radiotherapy and chemotherapy in FISS treatment has been studied, and a correlation between "clean" surgical margins and disease-free survival has been shown. In addition, clean surgical margins are one of the most important factors for achieving a low recurrence rate. The most effective method of FISS treatment includes combining radical surgery with pre- or postoperative radiotherapy...
July 17, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28707264/evaluation-of-propylene-glycol-nanoliposomes-containing-curcumin-on-burn-wound-model-in-rat-biocompatibility-wound-healing-and-anti-bacterial-effects
#18
Nooshin Kianvash, Abbas Bahador, Maryam Pourhajibagher, Homanaz Ghafari, Vahid Nikoui, Sayed Mehdi Rezayat, Ahmad Reza Dehpour, Alireza Partoazar
Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28698667/phylogenetic-analysis-reveals-two-genotypes-of-the-emerging-fungus-mucor-indicus-an-opportunistic-human-pathogen-in-immunocompromised-patients
#19
Saad J Taj-Aldeen, Muna Almaslamani, Bart Theelen, Teun Boekhout
Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28697465/combined-photodynamic-and-antibiotic-therapy-for-skin-disorder-via-lipase-sensitive-liposomes-with-enhanced-antimicrobial-performance
#20
Songhee Jeong, Jonghwan Lee, Byeong Nam Im, Hyung Park, Kun Na
A lipase-sensitive singlet oxygen-producible and erythromycin-loaded liposome (LSSPL) was developed for combination antibacterial therapy for skin disorder. The LSSPL was synthesized by coating pullulan-pheophorbide a (PU-Pheo A) conjugates onto erythromycin-loaded liposomes composed of 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) and cholesterol. Lipase activity was chosen as the environmental-stimulus for the controlled release of erythromycin and Pheo A from LSSPL because skin inflammation-inducing Propionibacterium acnes (P...
July 6, 2017: Biomaterials
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