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idiopathic cardiomyopathy

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https://www.readbyqxmd.com/read/29782370/a-common-polymorphism-in-the-scn5a-gene-is-associated-with-dilated-cardiomyopathy
#1
Cristina Mazzaccara, Giuseppe Limongelli, Mario Petretta, Rossella Vastarella, Giuseppe Pacileo, Domenico Bonaduce, Francesco Salvatore, Giulia Frisso
AIMS: SCN5A is a disease-causing gene associated with familial dilated cardiomyopathy (FDC). We examined the possible association between a common polymorphism in the SCN5A gene (c.1673A>G-p.H558R; rs1805124) and the risk of dilated cardiomyopathy (DCM) occurrence. METHODS: We genotyped 185 DCM cases (familial DCM, idiopathic DCM and postischemic DCM) and 251 controls for the p.H558R polymorphism in the SCN5A gene, to test the association of the molecular epidemiology of the individuals with the presence/absence of various types of DCM...
May 17, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29775428/the-involvement-of-human-monogenic-cardiomyopathy-genes-in-experimental-polygenic-cardiac-hypertrophy
#2
Priscilla R Prestes, Francine Z Marques, Guillermo Lopez-Campos, Paul Lewandowski, Lea M D Delbridge, Fadi J Charchar, Stephen B Harrap
Hypertrophic cardiomyopathy thickens heart muscles reducing functionality and increasing risk of cardiac disease and morbidity. Genetic factors are involved, but their contribution is poorly understood. We used the hypertrophic heart rat (HHR), a unique normotensive polygenic model of cardiac hypertrophy and heart failure to investigate the role of genes associated with monogenic human cardiomyopathy. We selected 42 genes involved in monogenic human cardiomyopathies to study: 1) DNA variants, by sequencing the whole-genome of 13-week old HHR and age-matched normal heart rat (NHR), its genetic control strain; 2) mRNA expression, by targeted RNA-sequencing in left ventricles of HHR and NHR at five ages (2-days old, 4-, 13-, 33- and 50-weeks old) compared to human idiopathic dilated data; and 3) microRNA expression, with rat microRNA microarrays in left ventricles of 2-days old HHR and age-matched NHR...
May 18, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29774407/beta-blockers-and-chronic-heart-failure-patients-prognostic-impact-of-a-dose-targeted-beta-blocker-therapy-vs-heart-rate-targeted-strategy
#3
Anna Corletto, Hanna Fröhlich, Tobias Täger, Matthias Hochadel, Ralf Zahn, Caroline Kilkowski, Ralph Winkler, Jochen Senges, Hugo A Katus, Lutz Frankenstein
BACKGROUND: Beta blockers improve survival in patients with chronic systolic heart failure (CHF). Whether physicians should aim for target dose, target heart rate (HR), or both is still under debate. METHODS AND RESULTS: We identified 1,669 patients with systolic CHF due to ischemic heart disease or idiopathic dilated cardiomyopathy from the University Hospital Heidelberg and the Clinic of Ludwigshafen, Germany. All patients were treated with an angiotensin converting enzyme inhibitor or angiotensin receptor blocker and had a history of CHF known for at least 6 months...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29745463/therapeutic-implications-of-a-combined-diagnostic-workup-including-endomyocardial-biopsy-in-an-all-comer-population-of-patients-with-heart-failure-a-retrospective-analysis
#4
Efthymios Sotiriou, Susanne Heiner, Thomas Jansen, Moritz Brandt, Kai Helge Schmidt, Karl-Friedrich Kreitner, Tilman Emrich, Heinz-Peter Schultheiss, Eberhard Schulz, Thomas Münzel, Philip Wenzel
BACKGROUND: Aetiology of heart failure (HF) often remains obscure. We therefore evaluated the usefulness of a combined diagnostic approach including cardiac magnetic resonance imaging (CMRI) and endomyocardial biopsy (EMB) to assess the cause of unexplained cardiomyopathy underlying HF. METHODS AND RESULTS: We retrospectively investigated 100 consecutive patients (36% women, mean age 53.6 ± 18.8 years) presenting with unexplained cardiomyopathy (HF with reduced ejection fraction or left ventricular hypertrophy; excluding ischaemic and valvular heart disease; left ventricular ejection fraction 31...
May 10, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29744939/heart-transplant-outcomes-in-patients-with-chagas-cardiomyopathy-in-the-united-states
#5
Rodolfo D Benatti, Sadeer G Al-Kindi, Fernando Bacal, Guilherme H Oliveira
BACKGROUND: Chagas cardiomyopathy (CC) is one of the chronic manifestations of Trypanosoma cruzi (T. cruzi) infection and is among the leading reasons for heart transplantation (HT) in Latin America. Chagas disease is also present in areas with large Hispanic communities in the United States. Our objective is to evaluate the outcomes of cardiac allograft recipients with the diagnosis of CC in the United States. METHODS AND RESULTS: We identified 25 adult patients with CC and 15,930 with idiopathic dilated cardiomyopathy (IDCMP) who underwent HT between 1987 and 2015...
May 9, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29718532/the-subcutaneous-implantable-cardioverter-defibrillator-a-tertiary-center-experience
#6
Cesar Khazen, Peter Magnusson, Johannes Flandorfer, Christoph Schukro
BACKGROUND: The aim of the study was to evaluate subcutaneous implantable cardioverter-defibrillator (S-ICD) patients with regard to underlying etiology, peri-procedural outcome, appropriate/inappropriate shocks, and complications during follow-up. METHODS: All patients who underwent S-ICD implantation from February 2013 to March 2017 at an academic hospital in Vienna were included. Medical records were examined and follow-up interrogations of devices were conducted...
May 2, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29706431/atrial-remodeling-and-metabolic-dysfunction-in-idiopathic-isolated-fibrotic-atrial-cardiomyopathy
#7
Chang Cui, Xiaohong Jiang, Weizhu Ju, Jiaxian Wang, Daowu Wang, Zheng Sun, Minglong Chen
BACKGROUND: Idiopathic isolated fibrotic atrial cardiomyopathy (IIF-ACM) is a novel subtype of cardiomyopathy characterized by atrial fibrosis that does not involve the ventricular myocardium and is associated with significant atrial tachyarrhythmia. The mechanisms underlying its pathogenesis are unknown. METHODS: Atrium samples were obtained from 3 patients with IIF-ACM via surgical intervention. Control samples were consisted of 3 atrium biopsies from patients with congenital heart disease and normal sinus rhythm, matched for gender, age and basic clinical characteristics...
April 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29687676/can-sudden-cardiac-death-in-the-young-be-predicted-and-prevented-lessons-from-autopsy-for-the-emergency-physician
#8
Jennifer L White, Anna Marie Chang, Sergi Cesar, Georgia Sarquella-Brugada
Sudden unexpected death in the young, though rare, is devastating for both the family and the community. Although only 1.3 to 8.5 cases of sudden cardiac death (SCD) occur per 100 000 young people, autopsy is often inconclusive. Many causes of SCD are related to autosomal dominant inherited risk, however; therefore, answers are important for survivors. Causes of autopsy-positive SCD in young patients include hypertrophic cardiomyopathy and arrhythmogenic right ventricular dysplasia. Autopsy-negative SCD has been related to inherited arrhythmogenic causes such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, Wolff- Parkinson-White syndrome, and idiopathic ventricular fibrillation...
June 2018: Emergencias: revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29686877/how-to-manage-various-arrhythmias-and-sudden-cardiac-death-in-the-cardiovascular-intensive-care
#9
REVIEW
Yoshinori Kobayashi
In the clinical practice of cardiovascular critical care, we often observe a variety of arrhythmias in the patients either with (secondary) or without (idiopathic) underlying heart diseases. In this manuscript, the clinical background and management of various arrhythmias treated in the CCU/ICU will be reviewed. The mechanism and background of lethal ventricular tachyarrhythmias vary as time elapses after the onset of MI that should be carefully considered to select a most suitable therapy. In the category of non-ischemic cardiomyopathy, several diseases are known to be complicated by the various ventricular tachyarrhythmias with some specific mechanisms...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29682528/the-relationship-between-serum-zinc-level-and-heart-failure-a-meta-analysis
#10
REVIEW
Xuefang Yu, Lei Huang, Jinyan Zhao, Zhuoqun Wang, Wei Yao, Xianming Wu, Jingjing Huang, Bo Bian
Zinc is essential for the maintenance of normal cellular structure and functions. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. However, there are conflicting reports on the relationship between serum zinc levels and heart failure (HF). The purpose of the present study is to explore the relationship between serum zinc levels and HF by using a meta-analysis approach. PubMed, Web of Science, and OVID databases were searched for reports on the association between serum zinc levels and HF until June 2016...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29678335/arrhythmic-risk-stratification-in-patients-with-idiopathic-dilated-cardiomyopathy
#11
Davide Stolfo, Nicole Ceschia, Massimo Zecchin, Antonio De Luca, Marco Gobbo, Giulia Barbati, Marta Gigli, Marco Masè, Bruno Pinamonti, Alberto Pivetta, Marco Merlo, Gianfranco Sinagra
Arrhythmic risk stratification in idiopathic dilated cardiomyopathy (IDC) remains a major concern. As the ventricles remodel in time, risk factors for arrhythmic death may change. A cohort of 710 patients with idiopathic dilated cardiomyopathy, without previous ventricular arrhythmias, was retrospectively studied to understand how risks vary in time. The primary end point was a composite of sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, and appropriate implantable cardioverter-defibrillator interventions...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29656687/longitudinal-evaluation-of-ventricular-ejection-fraction-and-nt-probnp-across-heart-failure-subgroups
#12
Andreas Martinsson, Petter Oest, Maj-Britt Wiborg, Öyvind Reitan, J Gustav Smith
OBJECTIVES: Left ventricular ejection fraction (EF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are important surrogate markers of cardiac function and wall stress. Randomized trials of heart failure (HF) have shown improvements in survival in patients with reduced EF (<40%, HFrEF) but not with preserved EF (≥50%, HFpEF) or mid-range EF (40-49%, HFmrEF). Limited information is available on the trajectory of EF in contemporary heart failure management programs (HFMPs)...
April 14, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29651540/identifying-non-invasive-tools-to-distinguish-acute-myocarditis-from-dilated-cardiomyopathy-in-children
#13
Divya Suthar, Debra A Dodd, Justin Godown
There is often a diagnostic dilemma in pediatric patients presenting with depressed ventricular function, as myocarditis and dilated cardiomyopathy (DCM) of other etiologies can appear very similar. Accurate identification is critical to guide treatment and to provide families with the most accurate expectation of long-term outcomes. The objective of this study was to identify patterns of clinical presentation and to assess non-invasive measures to differentiate patients with acute myocarditis from other forms of DCM...
April 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29619572/-recognizing-rare-cardiac-diseases-by-electrocardiogram
#14
REVIEW
W Grimm, A Grimm, K Grimm, E Efimova
A number of rare cardiac diseases can be recognized by electrocardiogram (ECG). This article illustrates the clinical importance of ECG as a key diagnostic tool to detect Wolff-Parkinson-White syndrome and channelopathies, which are frequently diagnosed late after one or more affected family members have become victims of sudden cardiac death. These channelopathies include long QT syndrome, short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. In addition, typical ECG findings are frequently present in patients with idiopathic ventricular tachycardia, arrhythmogenic right ventricular dysplasia, digitalis intoxication, hyperkalemia, acute cor pulmonale due to pulmonary embolism, as well as severe left ventricular hypertrophy as in hypertrophic cardiomyopathy...
April 4, 2018: Der Internist
https://www.readbyqxmd.com/read/29600790/biatrial-electrical-and-structural-atrial-changes-in-heart-failure-electroanatomic-mapping-in-persistent-atrial-fibrillation-in-humans
#15
Sandeep Prabhu, Aleksandr Voskoboinik, Alex J A McLellan, Kah Y Peck, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
OBJECTIVES: This study sought to characterize the biatrial substrate in heart failure (HF) and persistent atrial fibrillation (PeAF). BACKGROUND: Atrial fibrillation (AF) and HF frequently coexist; however, the contribution of HF to the biatrial substrate in PeAF is unclear. METHODS: Consecutive patients with PeAF and normal left ventricular (NLV) systolic function (left ventricular ejection fraction [LVEF] >55%) or idiopathic cardiomyopathy (LVEF ≤45%) undergoing AF ablation were enrolled...
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29579878/prognostic-value-of-blood-panel-parameters-in-patients-with-dilated-cardiomyopathy-and-advanced-heart-failure
#16
J M Sobrino-Márquez, A Grande-Trillo, E M Cantero-Pérez, D Rangel-Sousa, E Lage-Galle, A Adsuar-Gómez
BACKGROUND: Patients with dilated cardiomyopathy (DCM) and left ventricular dysfunction have a varied clinical course, not only dependent on left ventricular ejection fraction (LVEF) and symptoms. Finding prognostic markers for stratification in these 2 conditions is a critical area of research. Our aim was determine the prognostic value of blood panel basic parameters. METHODS: We analyzed all patients with idiopathic or familial DCM and LVEF <30% coming to our heart failure unit for evaluation for non-urgent heart transplant during the period of 2009 to 2011...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29578284/long-term-prognosis-subsequent-pregnancy-contraception-and-overall-management-of-peripartum-cardiomyopathy-practical-guidance-paper-from-the-heart-failure-association-of-the-european-society-of-cardiology-study-group-on-peripartum-cardiomyopathy
#17
Karen Sliwa, Mark C Petrie, Denise Hilfiker-Kleiner, Alexandre Mebazaa, Alice Jackson, Mark R Johnson, Peter van der Meer, Amam Mbakwem, Johann Bauersachs
Peripartum cardiomyopathy is an idiopathic cardiomyopathy presenting with heart failure secondary to left ventricular systolic dysfunction towards the end of pregnancy or in the months following delivery, where no other cause for heart failure is identified. Outcome varies from full recovery to residual left ventricular systolic dysfunction and even death. Many women return to their physician to acquire information on their long-term prognosis, to seek medical advice regarding contraception, or when planning a subsequent pregnancy...
March 26, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29577764/-immunoadsorption-in-a-patient-with-dilated-cardiomyopathy-the-first-case-in-hungary
#18
Pál Soltész, Melinda Vass, Ágnes Diószegi, Ivetta Mányiné Siket, Ildikó Garai, Csaba Kun, Orsolya Bene, Attila Kertész, István Édes
Dilated cardiomyopathy is the main cause of heart transplantation. The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD/heart transplantation-free survival can be prolonged...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29575985/successful-treatment-of-severe-combined-post-and-pre-capillary-pulmonary-hypertension-in-a-patient-with-idiopathic-restrictive-cardiomyopathy
#19
Satomi Ishihara, Hidetaka Kioka, Tomohito Ohtani, Yoshihiro Asano, Osamu Yamaguchi, Shungo Hikoso, Koichi Toda, Yoshihiko Saito, Yoshiki Sawa, Keiko Yamauchi-Takihara, Yasushi Sakata
Restrictive cardiomyopathy (RCM) is a rare form of cardiomyopathy that is characterized by restrictive ventricular filling. Elevated filling pressure leads to pulmonary hypertension (PH), which often progresses to combined post- and pre-capillary PH (Cpc-PH) with increased diastolic pulmonary vascular pressure gradient (DPG) and pulmonary vascular resistance (PVR) caused by longstanding backward hemodynamic consequences of left heart disease (LHD) leading to morphological changes in the pulmonary vasculature...
July 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29550522/diagnostic-value-and-prognostic-implications-of-early-cardiac-magnetic-resonance-in-survivors-of-out-of-hospital-cardiac-arrest
#20
Alessandro Zorzi, Angela Susana, Manuel De Lazzari, Federico Migliore, Giovanni Vescovo, Daniele Scarpa, Anna Baritussio, Giuseppe Tarantini, Luisa Cacciavillani, Benedetta Giorgi, Cristina Basso, Sabino Iliceto, Chiara Bucciarelli Ducci, Domenico Corrado, Martina Perazzolo Marra
BACKGROUND: In patients who survived out-of-hospital cardiac arrest (OHCA), it is crucial to establish the underlying cause and its potential reversibility. OBJECTIVE: The purpose of this study was to assess the incremental diagnostic and prognostic role of early cardiac magnetic resonance (CMR) in survivors of OHCA. METHODS: Among 139 consecutive OHCA patients, the study enrolled 44 patients (median age 43 years; 84% male) who underwent coronary angiography and CMR ≤7 days after admission...
March 15, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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