keyword
MENU ▼
Read by QxMD icon Read
search

pcv 10

keyword
https://www.readbyqxmd.com/read/29329169/differences-in-immunization-site-pain-in-toddlers-vaccinated-with-either-the-10-or-the-13-valent-pneumococcal-conjugate-vaccine
#1
Johannes Trück, Sarah Kelly, Sena Jawad, Matthew D Snape, Merryn Voysey, Andrew J Pollard
We investigated immediate immunization pain in 12-month-old children randomized to receive a booster dose of either the 10- (PCV-10) or the 13-valent (PCV-13) pneumococcal conjugate vaccine. Pain was assessed using validated pain assessment tools and crying time. PCV-13 recipients had significantly higher scores on the observer-rated modified behavioral pain scale than did those receiving PCV-10, but the differences were small.Clinical trial registration at Clinicaltrials.gov (NCT01443416).
January 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29323771/association-of-igfn1-variant-with-polypoidal-choroidal-vasculopathy
#2
Xiaofeng Wen, Yu Liu, Qi Yan, Minling Liang, Miao Tang, Ran Liu, Jianying Pan, Qiuhui Liu, Tingting Chen, Shixin Guo, Juanran Liang, Lin Lu, Xiaoyan Ding, Wei Chen, Lai Wei
BACKGROUND: Polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) share similar phenotype but are different in clinical manifestations, responses to treatment, and prognosis. Whether PCV is a subtype of AMD or a distinct entity from nAMD remains elusive. Therefore, we performed a whole-exome sequencing (WES) based association analysis to compare the genetic architecture of PCV and nAMD in Han Chinese. METHODS: Whole-exome sequencing analysis was performed on 21 nAMD cases, 20 PCV cases and 20 healthy controls...
January 11, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29323541/development-of-a-targeted-next-generation-sequencing-assay-to-detect-diagnostically-relevant-mutations-of-jak2-calr-and-mpl-in-myeloproliferative-neoplasms
#3
Thomas Frawley, Cathal P O'Brien, Eibhlin Conneally, Elisabeth Vandenberghe, Melanie Percy, Stephen E Langabeer, Karl Haslam
BACKGROUND: The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), consisting of polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are a heterogeneous group of neoplasms that harbor driver mutations in the JAK2, CALR, and MPL genes. The detection of these mutations has been incorporated into the recent World Health Organization (WHO) diagnostic criteria for MPN. Given a pressing clinical need to screen for these mutations in a routine diagnostic setting, a targeted next-generation sequencing (NGS) assay for the detection of MPN-associated mutations located in JAK2 exon 14, JAK2 exon 12, CALR exon 9, and MPL exon 10 was developed to provide a single platform alternative to reflexive, stepwise diagnostic algorithms...
January 11, 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29304066/burden-of-invasive-pneumococcal-disease-among-children-in-rural-mozambique-2001-2012
#4
Betuel Sigaúque, Jennifer R Verani, Sérgio Massora, Delfino Vubil, Llorenç Quintó, Sozinho Acácio, Inácio Mandomando, Quique Bassat, Tacilta Nhampossa, Fabiana Pimenta, Charfudin Sacoor, Maria da Gloria Carvalho, Eusebio Macete, Pedro L Alonso
BACKGROUND: Invasive pneumococcal disease (IPD) is a major cause of illness and death among children worldwide. 10-valent pneumococcal conjugate vaccine (PCV10) was introduced as part of the Mozambican routine immunization program in April 2013. We characterized the IPD burden in a rural area of Mozambique before PCV introduction and estimated the potential impact of this intervention. METHODS: We conducted population-based surveillance for IPD, defined as S. pneumoniae isolated from blood or cerebrospinal fluid, among children <5 years old admitted to Manhiça District Hospital, a referral hospital in a rural area with high prevalence of human immunodiciency virus infection...
2018: PloS One
https://www.readbyqxmd.com/read/29285580/bone-marrow-findings-in-blast-phase-of-polycythemia-vera
#5
Juliana E Hidalgo López, Adrian Carballo-Zarate, Srdan Verstovsek, Sa A Wang, Shimin Hu, Shaoying Li, Jie Xu, Wenli Zuo, Zhenya Tang, C Cameron Yin, L Jeffrey Medeiros, Carlos E Bueso-Ramos, Guilin Tang
Approximately 10% of patients with polycythemia vera (PV) transform to acute leukemia (blast phase) at 10 years after initial diagnosis of PV. The bone marrow pathologic, cytogenetic, and molecular features of blast phase have not been well characterized. In this study, we reviewed 422 PV patients over a period of 11 years and identified 58 patients who developed acute myeloid leukemia (blast phase) during the course of disease. We found that blast phase of PV was characterized by overt myelodysplasia (n = 51, 88%); moderate to severe myelofibrosis (33 of 45, 73%); an abnormal karyotype (n = 51, 88%) that was often complex karyotype (n = 42, 72%); and gene mutations involving TP53 (55%), TET2 (27%), and DNMT3A (25%)...
December 28, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29218131/hypocalcemia-associated-with-subcutaneous-fat-necrosis-of-the-newborn-case-report-and-literature-review
#6
Alphonsus N Onyiriuka, Theodora E Utomi
Subcutaneous fat necrosis of the newborn (SCFNN) is a rare benign inflammatory disorder of the adipose tissue but may be complicated by hypercalcemia or less frequently, hypocalcemia, resulting in morbidity and mortality. Here we report the case of a neonate with subcutaneous fat necrosis who surprisingly developed hypocalcemia instead of hypercalcemia. A full-term female neonate was delivered by emergency cesarean section for fetal distress and was subsequently admitted to the Special Care Baby Unit. The mother's pregnancy was uncomplicated up to delivery...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29212537/association-of-arms2-genotype-with-response-to-anti-vascular-endothelial-growth-factor-treatment-in-polypoidal-choroidal-vasculopathy
#7
Un Chul Park, Joo Young Shin, Hum Chung, Hyeong Gon Yu
BACKGROUND: To investigate whether genetic risk variants for age-related macular degeneration (AMD) are associated with response to intravitreal anti-vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV) patients. METHODS: This prospective cohort study included 95 treatment-naïve patients that underwent anti-VEGF treatment for PCV for 12 months. Patients were genotyped for 10 single nucleotide polymorphisms in eight AMD-relevant genes...
December 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29184088/comparison-of-two-year-outcomes-after-photodynamic-therapy-with-ranibizumab-or-aflibercept-for-polypoidal-choroidal-vasculopathy
#8
Wataru Kikushima, Yoichi Sakurada, Atsushi Sugiyama, Seigo Yoneyama, Naohiko Tanabe, Mio Matsubara, Fumihiko Mabuchi, Hiroyuki Iijima
Photodynamic therapy (PDT) combined with intravitreal anti-vascular endothelial growth factor (VEGF) agents is currently the first-line treatment for polypoidal choroidal vasculopathy (PCV), along with anti-VEGF monotherapy. In this study, 100 eyes with treatment-naïve PCV were initially treated with PDT combined with intravitreal ranibizumab (IVR; n = 57) or aflibercept (IVA; n = 43). We compared two-year outcomes between these two groups and investigated factors associated with visual improvement and retreatment over 24 months...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29181548/non-driver-mutations-in-patients-with-jak2v617f-mutated-polycythemia-vera-or-essential-thrombocythemia-with-long-term-molecular-follow-up
#9
Alicia Senín, Concepción Fernández-Rodríguez, Beatriz Bellosillo, Laura Camacho, Raquel Longarón, Anna Angona, Carles Besses, Alberto Álvarez-Larrán
JAK2V617F monitoring and NGS of non-driver genes was performed in 100 patients with polycythemia vera (PV) or essential thrombocythemia (ET) with long molecular follow-up. Patients who did not progress to myelofibrosis (MF) or acute myeloid leukemia (AML) after more than 10 years (n = 50) showed a low frequency of mutations at first sample (18%) and an incidence rate of 1.7 new mutations × 100 person-years. Mutations were detected at first sample in 83% of PV/ET patients who later progressed to AML (n = 12) with these patients having a rate of 25...
November 27, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29174323/pneumococcal-conjugate-vaccine-13-delivered-as-one-primary-and-one-booster-dose-1%C3%A2-%C3%A2-1-compared-with-two-primary-doses-and-a-booster-2%C3%A2-%C3%A2-1-in-uk-infants-a-multicentre-parallel-group-randomised-controlled-trial
#10
David Goldblatt, Jo Southern, Nick J Andrews, Polly Burbidge, Jo Partington, Lucy Roalfe, Marta Valente Pinto, Vasilli Thalasselis, Emma Plested, Hayley Richardson, Matthew D Snape, Elizabeth Miller
BACKGROUND: Infants in the UK were first offered a pneumococcal conjugate vaccine (PCV7) in 2006, given at 2 and 4 months of age and a booster dose at 13 months (2 + 1 schedule). A 13-valent vaccine (PCV13) replaced PCV7 in 2010. We aimed to compare the post-booster antibody response in UK infants given a reduced priming schedule of PCV13 (ie, a 1 + 1 schedule) versus the current 2 + 1 schedule and to assess the potential effect on population protection. METHODS: In this multicentre, parallel group, randomised controlled trial, we recuited infants due to receive their primary immunisations aged up to 13 weeks on first vaccinations by information booklets mailed out via the NHS Child Health Information Service and the UK National Health Application and Infrastructure Services...
November 22, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29169154/development-of-age-related-macular-degeneration-amd-in-the-fellow-eye-of-patients-with-amd-treated-by-treat-and-extend-intravitreal-therapy-with-aflibercept
#11
Kensuke Mimura, Hidetaka Matsumoto, Masahiro Morimoto, Hideo Akiyama
PURPOSE: To evaluate the development of neovascular age-related macular degeneration (nAMD) in the fellow eye in patients with unilateral nAMD treated by a treat-and-extend (TAE) regimen with intravitreal aflibercept injections. METHODS: We retrospectively studied 104 patients with treatment-naïve unilateral nAMD. We assessed best-corrected visual acuity (BCVA) and exudative changes in the treated eyes and development of nAMD in the fellow eye for 2 years. RESULTS: The subjects included 46 patients with typical AMD (tAMD), 44 with polypoidal choroidal vasculopathy (PCV), and 14 with retinal angiomatous proliferation (RAP)...
November 23, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29164952/review-of-vaccine-effectiveness-assumptions-used-in-economic-evaluations-of-infant-pneumococcal-conjugate-vaccine
#12
Matthew Wasserman, Heather Sings, Dylan Jones, Sarah Pugh, Margaret Moffatt, Raymond Farkouh
Pneumococcal conjugate vaccines (PCVs) have provided a significant clinical and economic impact globally. The majority of countries which have implemented an infant PCV program have observed a substantial reduction in the burden of invasive pneumococcal disease (IPD), pneumococcal pneumonia, and acute otitis media (AOM) due to vaccine serotypes. After 17 years of use, many countries have evaluated and re-evaluated the value of their vaccine program using cost-effectiveness analyses; however, many of these analyses do not reflect the current body of evidence...
November 22, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29150886/ruxolitinib-associated-infections-a-systematic-review-and-meta-analysis
#13
Federico Lussana, Marco Cattaneo, Alessandro Rambaldi, Alessandro Squizzato
Ruxolitinib exerts immunosuppressive activity that may increase the risk of infectious complications. We performed a systematic review of the literature with the aim of estimating the risk of infections in patients treated with ruxolitinib. Studies were identified by electronic search of MEDLINE and EMBASE database. Differences in the incidence of infectious events between ruxolitinib and comparison groups were expressed as odds ratios (ORs) and 95% confidence intervals (95% CI). Five phase III randomized clinical trials (RCTs) (3 phase IIIa with their extended phase and 2 phase IIIb), 6 phase IV studies and 28 case reports were included in this systematic review...
November 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29143923/impact-of-concurrent-versus-adjuvant-chemotherapy-on-the-severity-and-duration-of-lymphopenia-in-glioma-patients-treated-with-radiation-therapy
#14
Alexander J Lin, Jian L Campian, Caressa Hui, Soumon Rudra, Yuan J Rao, Dinesh Thotala, Dennis Hallahan, Jiayi Huang
Prolonged severe lymphopenia has been shown to persist beyond a year in glioma patients after radiation therapy (RT) with concurrent and adjuvant chemotherapy. This study examines the differential impact of concurrent versus adjuvant chemotherapy on lymphopenia after RT. WHO grade II-III glioma patients who received RT with concurrent and/or adjuvant chemotherapy from 2007 to 2016 were retrospectively analyzed. Concurrent chemotherapy was temozolomide (TMZ), and adjuvant chemotherapy was either TMZ or procarbazine/lomustine/vincristine (PCV)...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29126217/change-in-pneumococcus-serotypes-but-not-mortality-or-morbidity-in-pre-and-post-13-valent-polysaccharide-conjugate-vaccine-era-epidemiology-in-a-pediatric-intensive-care-unit-over-10-years
#15
Kam Lun Hon, King Hang Chan, Pak Long Ko, Michelle Ho Yan Cheung, Kathy Yin C Tsang, Lawrence C N Chan, Renee W Y Chan, Ting Fan Leung, Margaret Ip
Aim: Pneumococcus is a common commensal and an important pathogen among children for which immunization is available. Some serotypes occasionally cause severe pneumococcal disease with high mortality and morbidity. We reviewed all pneumococcal serotypes and mortality/morbidity in a pediatric intensive care unit (PICU) following universal pneumococcal conjugate vaccine (PCV) immunization. Methods: A 13-valent PCV was introduced in the universal immunization program in late 2011 in Hong Kong...
November 6, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29124059/evaluation-of-three-hydration-strategies-in-detection-dogs-working-in-a-hot-environment
#16
Cynthia M Otto, Elizabeth Hare, Jess L Nord, Shannon M Palermo, Kathleen M Kelsey, Tracy A Darling, Kasey Schmidt, Destiny Coleman
Physical activity in hot environments can increase the risk of heat stress or heat stroke in dogs. Heat tolerance is influenced by acclimatization to the environment, physical fitness, and hydration state. Three common strategies to promote hydration in working dogs are free access to water (W), oral electrolyte solutions (OESs), and administration of subcutaneous fluids (SQs). None of these methods have been compared for safety or efficacy in a working environment. In a cross-over design, seven vehicle-screening canines were randomly assigned to each of the three hydration strategies during working shifts at the Sarita, TX checkpoint...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29115905/cost-effectiveness-analysis-of-infant-pneumococcal-vaccination-with-phid-cv-in-korea
#17
Xu-Hao Zhang, Oscar Leeuwenkamp, Kyu-Bin Oh, Young Eun Lee, Chul-Min Kim
BACKGROUND: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV-13) are included in the National Immunization Program for infants in Korea. This study aimed to evaluate the cost-effectiveness of the 3+1 schedule of PHiD-CV versus that of PCV-13 for National Immunization Program in Korea...
November 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29114150/response-of-outbred-albino-mice-to-concomitant-heligmosomoides-bakeri-plasmodium-berghei-and-trypanosoma-brucei-infections
#18
Lucas Atehmengo Ngongeh, Amaechi Onyeabor, Munachi Ihuoma Wosu, Samson Kansalem Gurama
To investigate the response of mice to concomitant infections with Trypanosoma brucei (Tb), Plasmodium berghei (Pb) and Heligmosomoides bakeri (Hb) infections. Each group of 6 mice was either infected with Pb + Tb + Hb, Pb + Tb, Pb + Hb, Tb + Hb, Pb, Tb, Hb or remained as uninfected controls. Hb infected mice each received 200 infective larvae (L3) of Hb orally, Tb infected mice each received 2 × 10(-6) organisms through the intraperitoneal route while Pb infected mice received 1 × 10(-5) parasitized red blood cells through the intraperitoneal route...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114142/gastrointestinal-parasitic-infections-in-indian-gaddi-goat-breed-bucks-clinical-hemato-biochemical-parasitological-and-chemotherapeutic-studies
#19
Aman Dev Moudgil, Ankur Sharma, Madan Singh Verma, Ravindra Kumar, Pradeep Kumar Dogra, Pallavi Moudgil
The present study was envisaged with an aim to evaluate gastrointestinal parasitic infections in a herd of conserved Gaddi (goat) breed bucks (6-9 months of age) kept on semi-intensive feeding management. The individuals (n = 20) representing the herd were selected and divided into two groups; group I (n = 10), clinically ill and group II (n = 10), sub clinically infected individuals. The clinical examination revealed anemia, emaciation and rise in body temperature of the individuals of group I as compared to group II...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29100304/germline-variations-at-jak2-tert-hbs1l-myb-and-mecom-and-the-risk-of-myeloproliferative-neoplasms-in-taiwanese-population
#20
Yi-Hao Chiang, Yu-Cheng Chang, Huan-Chau Lin, Ling Huang, Chun-Chia Cheng, Wei-Ting Wang, Hung-I Cheng, Nai-Wen Su, Caleb Gon-Shen Chen, Johnson Lin, Yi-Fang Chang, Ming-Chih Chang, Ruey-Kuen Hsieh, Wen-Chien Chou, Ken-Hong Lim, Yuan-Yeh Kuo
Germline variations at JAK2, TERT, HBS1L-MYB and MECOM have been found to associate with myeloproliferative neoplasms (MPNs) in European populations. Whether these germline variations are associated with MPNs in Taiwanese population is obscure. Here we aimed to evaluate the association of five germline variations (JAK2 46/1 haplotype tagged by rs12343867, JAK2 intron 8 rs12339666, TERT rs2736100, HBS1L-MYB rs9376092 and MECOM rs2201862) and the risk of MPNs in Taiwanese population. A total of 178 MPN patients (109 essential thrombocythemia, 54 polycythemia vera and 15 primary myelofibrosis) were enrolled into this study...
September 29, 2017: Oncotarget
keyword
keyword
100560
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"