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https://www.readbyqxmd.com/read/29781740/predicting-the-impact-of-pneumococcal-conjugate-vaccine-programme-options-in-vietnam
#1
Olivier Le Polain de Waroux, W John Edmunds, Kensuke Takahashi, Koya Ariyoshi, E Kim Mulholland, David Goldblatt, Yoon Hong Choi, Dang Duc Anh, Lay Myint Yoshida, Stefan Flasche
Although catch-up campaigns (CCs) at the introduction of pneumococcal conjugate vaccines (PCVs) may accelerate their impact, supply constraints may limit their benefit if the need for additional PCV doses results in introduction delay. We studied the impact of PCV13 introduction with and without CC in Nha Trang, Vietnam - a country that has not yet introduced PCV - through a dynamic transmission model. We modelled the impact on carriage and invasive pneumococcal disease (IPD) of routine vaccination (RV) only and that of RV with CCs targeting <1y olds (CC1), <2y olds (CC2) and <5y olds (CC5)...
May 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29778481/health-benefits-of-orally-administered-anti-il-10-antibody-in-milk-fed-dairy-calves
#2
S M Raabis, T L Ollivett, M E Cook, J M Sand, S M McGuirk
The primary objective of this randomized controlled trial was to determine whether anti-IL-10 egg yolk antibodies fed upon arrival to a calf ranch would lower the prevalence of Cryptosporidium parvum shedding in naturally challenged preweaned dairy calves. The secondary objectives included measuring the effect of anti-IL-10 antibodies on calf health, performance, and shedding of less common diarrheal pathogens. A total of 133 calves, enrolled at 24 to 72 h of age, received a daily dose of 0.96 g of egg yolk powder with anti-IL-10 antibodies (MAB, n = 71) or without anti-IL-10 antibodies (MEP, n = 62) split between 2 feedings for the first 11 d on feed at a calf ranch...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29764550/-predictive-value-of-central-venous-to-arterial-carbon-dioxide-partial-pressure-difference-for-fluid-responsiveness-in-septic-shock-patients-a-prospective-clinical-study
#3
Guangyun Liu, Huibin Huang, Hanyu Qin, Bin Du
OBJECTIVE: To evaluate the accuracy of central venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2 ) before and after rapid rehydration test (fluid challenge) in predicting the fluid responsiveness in patients with septic shock. METHODS: A prospective observation was conducted. Forty septic shock patients admitted to medical intensive care unit (ICU) of Peking Union Medical College Hospital from October 2015 to June 2017 were enrolled. All of the patients received fluid challenge in the presence of invasive hemodynamic monitoring...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29757851/effect-of-posterior-corneal-vesicles-on-corneal-endothelial-cell-density-and-anisometropic-amblyopia
#4
Atsushi Noguchi, Naoki Okumura, Chie Sotozono, Shigeru Kinoshita
PURPOSE: To evaluate the effect of corneal vesicles in patients with posterior corneal vesicles (PCV) on corneal endothelial cell (CEC) density and the acquisition of amblyopia. METHODS: In this retrospective study of patients with PCV (18 eyes of 14 patients), CEC density was examined by noncontact specular microscopy during each follow-up examination. Best-corrected visual acuity and the objective refractive error were also examined. RESULTS: Of the 14 total patients, 10 were diagnosed with PCV and 4 were diagnosed with bilateral suspected PCV or posterior polymorphous corneal dystrophy (PPCD), and in all patients, no ocular abnormality other than corneal vesicles was observed...
May 1, 2018: Cornea
https://www.readbyqxmd.com/read/29752840/hematological-and-immunological-reference-intervals-for-adult-population-in-the-state-of-amhara-ethiopia
#5
Bamlaku Enawgaw, Wubet Birhan, Molla Abebe, Betelihem Terefe, Habtamu Wondifraw Baynes, Tekalign Deressa, Mulugeta Melku
OBJECTIVE: Reference intervals (RIs) currently being used in Ethiopia are derived from western populations. Thus, this study aimed to establish locally derived hematological and immunological RIs. METHOD: The study was conducted in Amhara State, Ethiopia with a total of 967 (55.2% males) participants. 56.9% of males and 43.1% of females were eligible for hematological and immunological RI determination. A non-parametric test was used for the determination of upper (97...
May 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29746511/choroidal-structure-as-a-biomarker-for-visual-acuity-in-intravitreal-aflibercept-therapy-for-polypoidal-choroidal-vasculopathy
#6
Shotaro Asano, Keiko Azuma, Kimiko Shimizu, Risako Yamamoto, Jinhee Lee, Hiroshi Murata, Tatsuya Inoue, Ryo Asaoka, Ryo Obata
PURPOSE: To investigate the relationship between choroidal structure and visual acuity after intravitreal aflibercept therapy for polypoidal choroidal vasculopathy (PCV). METHODS: We conducted a retrospective, single-centre and observational study including 18 eyes of 18 patients with PCV (73.8 ± 10.2 years of age) who were treated with three monthly intravitreal aflibercept injections followed by additional treatments in a treat-and-extend protocol. The cross-sectional images of the macula were obtained with enhanced depth imaging optical coherence tomography at baseline, at 3 months, and at 12 months...
2018: PloS One
https://www.readbyqxmd.com/read/29707298/effects-of-volume-controlled-ventilation-vs-pressure-controlled-ventilation-on-respiratory-function-and-inflammatory-factors-in-patients-undergoing-video-assisted-thoracoscopic-radical-resection-of-pulmonary-carcinoma
#7
Jing Tan, Zhenghuan Song, Qingming Bian, Pengyi Li, Lianbing Gu
Background: The best ventilation approach for patients undergoing video-assisted thoracic surgery (ATS) for pulmonary carcinoma remains undefined. This study aimed to assess hemodynamics, airway pressure, arterial blood gas, and inflammatory factors in patients undergoing VATS for pulmonary carcinoma under volume-controlled ventilation (VCV) or pressure-controlled ventilation (PCV). Methods: This was a prospective study of 60 patients with pulmonary carcinoma treated at a tertiary center in 2015-2016...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29702658/use-of-weighted-multivariate-estimates-in-trials-of-multi-serotype-vaccines-to-simplify-interpretation-of-treatment-differences
#8
Merryn Voysey, Andrew J Pollard, Rafael Perera, Shrijana Shrestha, Stephen Thorson, Thomas R Fanshawe
BACKGROUND: Many vaccines contain multiple components. Licensed pneumococcal conjugate vaccines (PCV) contain polysaccharides from 7, 10, or 13 different serotypes of Streptococcus pneumoniae. The main outcomes in randomised trials of pneumococcal vaccines are serotype-specific antibody measures. Comparisons are made between groups for each serotype, resulting in multiple separate comparisons of treatment effects which can be complicated to interpret. We investigated methods for computing the overall difference between vaccine groups across all serotypes...
2018: PloS One
https://www.readbyqxmd.com/read/29682367/myelodysplastic-syndrome-acute-myeloid-leukemia-arising-in-idiopathic-erythrocytosis
#9
Stephen E Langabeer, Eibhlin Conneally, Catherine M Flynn
The term "idiopathic erythrocytosis (IE)" is applied to those cases where a causal clinical or pathological event cannot be elucidated and likely reflects a spectrum of underlying medical and molecular abnormalities. The clinical course of a patient with IE is described manifesting as a persistent erythrocytosis with a low serum erythropoietin level, mild eosinophilia, and with evidence of a thrombotic event. The patient subsequently developed a myelodysplasic syndrome (MDS) and acute myeloid leukemia (AML), an event not observed in erythrocytosis patients other than those with polycythemia vera (PV)...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29676359/molecular-genetics-of-bcr-abl1-negative-myeloproliferative-neoplasms-in-india
#10
Nikhil Rabade, P G Subramanian, Rohan Kodgule, Goutham Raval, Swapnali Joshi, Shruti Chaudhary, Russel Mascarenhas, Prashant Tembhare, Sumeet Gujral, Nikhil Patkar
Introduction: Over the past decade, we have moved on from a predominantly morphological and clinical classification of myeloproliferative neoplasms (MPN) to a more evolved classification that accounts for the molecular heterogeneity that is unique to this subgroup of hematological malignancies. This usually incorporates mutations in Janus kinase 2 (JAK2), MPL, and calreticulin (CALR) genes. In this manuscript, we report the frequency of these mutations in a cohort of Indian patients at a tertiary cancer center...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29668816/compliance-with-the-vaccination-schedule-in-children-hospitalized-with-pneumonia-and-associated-factors
#11
Amanda Tabosa Pereira da Silva, Eduardo Jorge da Fonseca Lima, Maria de Fátima Costa Caminha, Andresa Tabosa Pereira da Silva, Edil de Albuquerque Rodrigues Filho, Carmina Silva Dos Santos
OBJECTIVE: To verify the adequacy and factors associated with compliance with the immunization schedule (BCG, DTP-Hib, MMR, PCV-10) in children hospitalized with pneumonia at a pediatric referral hospital in Northeast Brazil. METHODS: This is a cross-sectional, descriptive study with an analytical component, with a sample of 452 children hospitalized with pneumonia at the Instituto de Medicina Integral Prof. Fernando Figueira, between 2010 and 2013. The inclusion criterion was children aged from one month to less than five years of age with proof in the immunization record...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29664706/evaluation-of-four-blood-glucose-monitoring-systems-for-self-testing-with-built-in-insulin-dose-advisor-based-on-iso-15197-2013-system-accuracy-and-hematocrit-influence
#12
Nina Jendrike, Annette Baumstark, Stefan Pleus, Christina Liebing, Alexandra Beer, Frank Flacke, Cornelia Haug, Guido Freckmann
BACKGROUND: Self-monitoring of blood glucose (SMBG) is important in diabetes therapy; however, not all SMBG systems are sufficiently accurate. In addition, some SMBG systems are influenced by the user's hematocrit value. METHODS: System accuracy and hematocrit influence was evaluated for four SMBG systems with built-in insulin dose advisors (Accu-Chek® Aviva Expert [1], FreeStyle InsuLinx [2], FreeStyle Precision Neo [3], MyStar DoseCoach® [4]) based on International Organization for Standardization (ISO) 15197:2013 section 6...
April 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29652440/long-term-visual-outcomes-for-treatment-of-submacular-hemorrhage-secondary-to-polypoidal-choroidal-vasculopathy
#13
Hyun Goo Kang, Hyunseung Kang, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Min Kim
IMPORTANCE: There is no consensus on the optimal management of submacular hemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV). BACKGROUND: To compare the long-term outcome of 3 treatment strategies for PCV with SMH. DESIGN: Retrospective case series at 2 tertiary hospitals. SAMPLES: A total of 48 consecutive eyes treated between July 2006 and March 2016. METHODS: Patients were grouped according to the treatment received: 22 eyes with intravitreal bevacizumab (IVB), 14 with a combination of IVB and pneumatic displacement (PD), and 12 with IVB and vitrectomy (TPPV)...
April 13, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29629644/development-and-validation-of-direct-pcr-and-quantitative-pcr-assays-for-the-rapid-sensitive-and-economical-detection-of-porcine-circovirus-3
#14
Giovanni Franzo, Matteo Legnardi, Cinzia Centelleghe, Claudia M Tucciarone, Mattia Cecchinato, Martí Cortey, Joaquim Segalés, Michele Drigo
Since the identification of species Porcine circovirus 2, the relevance of genus Circovirus has increased given its impact on the swine industry. A new species ( Porcine circovirus 3, PCV-3) has been detected in association with various clinical conditions. Consequently, there is an urgent need for reliable and widely accessible tests for both routine diagnostic and research purposes. We developed a direct PCR (requiring no DNA extraction) and a quantitative (q)PCR targeting the conserved rep gene to detect the PCV-3 genome...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29623819/register-based-ecologic-evaluation-of-safety-signals-related-to-pneumococcal-conjugate-vaccine-in-children
#15
Miia Artama, Hanna Rinta-Kokko, Hanna Nohynek, Jukka Jokinen, Arto Palmu
BACKGROUND: In clinical trials of Pneumococcal Conjugate Vaccines (PCV), some adverse events have been reported more frequently in the PCV vaccinated. Ten-valent PCV (PCV10) was introduced into the Finnish National Vaccination Programme (NVP) in September 2010. OBJECTIVES: We conducted an ecologic register-based study to investigate further the reported adverse events after PCV. METHODS: This study included data obtained from the Finnish nationwide, population-based registers...
April 6, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29601605/increased-carriage-of-non-vaccine-serotypes-with-low-invasive-disease-potential-four-years-after-switching-to-the-10-valent-pneumococcal-conjugate-vaccine-in-the-netherlands
#16
Marloes Vissers, Alienke J Wijmenga-Monsuur, Mirjam J Knol, Paul Badoux, Marlies A van Houten, Arie van der Ende, Elisabeth A M Sanders, Nynke Y Rots
The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in The Netherlands in 2006 and was replaced by PHiD-CV10 in 2011. Data on carriage prevalence of S. pneumoniae serotypes in children and invasive pneumococcal disease (IPD) in children and older adults were collected to examine the impact of PCVs on carriage and IPD in The Netherlands. Pneumococcal carriage prevalence was determined by conventional culture of nasopharyngeal swabs in 24-month-old children in 2015/2016. Data were compared to similar carriage studies in 2005 (pre-PCV7 introduction), 2009, 2010/2011 and 2012/2013...
2018: PloS One
https://www.readbyqxmd.com/read/29564688/detection-and-genetic-characterisation-of-porcine-circovirus-3-from-pigs-in-sweden
#17
Xingyu Ye, Mikael Berg, Caroline Fossum, Per Wallgren, Anne-Lie Blomström
Porcine circovirus 3 (PCV3) is a newly detected circovirus belonging to the family Circoviridae with a circular ssDNA genome of 2000 bp that encodes two proteins-the replicase protein and the capsid protein. PCV3 was discovered for the first time in the US in 2016. After this initial discovery, PCV3 was detected in other parts of the world such as in China, South Korea, Italy and Poland. In this study, 49 tissue samples from Swedish pig herds were screened for PCV3 using PCR and 10 samples were positive and one was uncertain...
March 21, 2018: Virus Genes
https://www.readbyqxmd.com/read/29517441/age-related-changes-in-hematology-and-blood-biochemistry-values-in-endangered-wild-ring-tailed-lemurs-lemur-catta-at-the-bez%C3%A3-mahafaly-special-reserve-madagascar
#18
Cora L Singleton, Michelle L Sauther, Frank P Cuozzo, Ibrahim Antho Youssouf Jacky
The health of 44 wild ring-tailed lemurs ( Lemur catta) at the Bezà Mahafaly Special Reserve was assessed across three age classes: <5 yr (young), 5-9 yr (adult), and ≥10 yr (old). Hematology and biochemistry tests were performed manually (leukocyte count and differential, packed cell volume, total protein) and using a point-of-care analyzer (hematocrit, hemoglobin, glucose, blood urea nitrogen, creatinine, sodium, potassium, chloride, ionized calcium, total carbon dioxide, anion gap), respectively. Urine specific gravity was measured via refractometry...
March 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29505522/the-effects-of-one-lung-ventilation-mode-on-lung-function-in-elderly-patients-undergoing-esophageal-cancer-surgery
#19
RANDOMIZED CONTROLLED TRIAL
Bao-Juan Zhang, Hai-Tao Tian, Hai-Ou Li, Jian Meng
The objective of the present study was to explore the effects of different one-lung ventilation (OLV) modes on lung function in elderly patients undergoing esophageal cancer surgery. A total of 180 consecutive elderly patients (ASA Grades I-II, with OLV indications) undergoing elective surgery were recruited in the study. Patients were randomly divided into 4 groups (n = 45). In Group A, patients received low tidal volume (VT < 8 mL/kg) + pressure controlled ventilation (PCV), low tidal volume (VT < 8 mL/kg) + volume-controlled ventilation (VCV) in Group B, high tidal volume (VT ≥ 8 mL/kg) + PCV in Group C and high tidal volume (VT ≥ 8 mL/kg) + VCV in Group D...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29497888/assessment-of-focal-laser-photocoagulations-early-effect-on-polypoidal-choroidal-vasculopathy-with-optical-coherence-tomography-angiography
#20
Erdem Eriş, İrfan Perente, Esra Vural, Dilek Yaşa, Abdullah Ozkaya
Polypoidal choroidal vasculopathy (PCV) is seen with polypoidal lesions and branching vascular networks (BVNs) (Spaide et al. in Retina 15(2):100-110, 1995; Yannuzzi et al. in Retina 10(1):1-8, 1990). There are reports about laser photocoagulation for PCV (Yuzawa et al. in Japan J Ophthalmol 47(4):379-384, 2003; Lee et al. in Eye 23(1):145-148, 2009); however, all these reports are about final vision and frequent relapses. Therefore, this treatment merits rigorous scrutiny using optical coherence tomography angiography (OCTA)...
March 2, 2018: Lasers in Medical Science
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