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https://www.readbyqxmd.com/read/29126217/change-in-pneumococcus-serotypes-but-not-mortality-or-morbidity-in-pre-and-post-13-valent-polysaccharide-conjugate-vaccine-era-epidemiology-in-a-pediatric-intensive-care-unit-over-10-years
#1
Kam Lun Hon, King Hang Chan, Pak Long Ko, Michelle Ho Yan Cheung, Kathy Yin C Tsang, Lawrence C N Chan, Renee W Y Chan, Ting Fan Leung, Margaret Ip
Aim: Pneumococcus is a common commensal and an important pathogen among children for which immunization is available. Some serotypes occasionally cause severe pneumococcal disease with high mortality and morbidity. We reviewed all pneumococcal serotypes and mortality/morbidity in a pediatric intensive care unit (PICU) following universal pneumococcal conjugate vaccine (PCV) immunization. Methods: A 13-valent PCV was introduced in the universal immunization program in late 2011 in Hong Kong...
November 6, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29124059/evaluation-of-three-hydration-strategies-in-detection-dogs-working-in-a-hot-environment
#2
Cynthia M Otto, Elizabeth Hare, Jess L Nord, Shannon M Palermo, Kathleen M Kelsey, Tracy A Darling, Kasey Schmidt, Destiny Coleman
Physical activity in hot environments can increase the risk of heat stress or heat stroke in dogs. Heat tolerance is influenced by acclimatization to the environment, physical fitness, and hydration state. Three common strategies to promote hydration in working dogs are free access to water (W), oral electrolyte solutions (OESs), and administration of subcutaneous fluids (SQs). None of these methods have been compared for safety or efficacy in a working environment. In a cross-over design, seven vehicle-screening canines were randomly assigned to each of the three hydration strategies during working shifts at the Sarita, TX checkpoint...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29115905/cost-effectiveness-analysis-of-infant-pneumococcal-vaccination-with-phid-cv-in-korea
#3
Xu-Hao Zhang, Oscar Leeuwenkamp, Kyu-Bin Oh, Young Eun Lee, Chul-Min Kim
BACKGROUND: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV-13) are included in the National Immunization Program for infants in Korea. This study aimed to evaluate the cost-effectiveness of the 3+1 schedule of PHiD-CV versus that of PCV-13 for National Immunization Program in Korea...
November 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29114150/response-of-outbred-albino-mice-to-concomitant-heligmosomoides-bakeri-plasmodium-berghei-and-trypanosoma-brucei-infections
#4
Lucas Atehmengo Ngongeh, Amaechi Onyeabor, Munachi Ihuoma Wosu, Samson Kansalem Gurama
To investigate the response of mice to concomitant infections with Trypanosoma brucei (Tb), Plasmodium berghei (Pb) and Heligmosomoides bakeri (Hb) infections. Each group of 6 mice was either infected with Pb + Tb + Hb, Pb + Tb, Pb + Hb, Tb + Hb, Pb, Tb, Hb or remained as uninfected controls. Hb infected mice each received 200 infective larvae (L3) of Hb orally, Tb infected mice each received 2 × 10(-6) organisms through the intraperitoneal route while Pb infected mice received 1 × 10(-5) parasitized red blood cells through the intraperitoneal route...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114142/gastrointestinal-parasitic-infections-in-indian-gaddi-goat-breed-bucks-clinical-hemato-biochemical-parasitological-and-chemotherapeutic-studies
#5
Aman Dev Moudgil, Ankur Sharma, Madan Singh Verma, Ravindra Kumar, Pradeep Kumar Dogra, Pallavi Moudgil
The present study was envisaged with an aim to evaluate gastrointestinal parasitic infections in a herd of conserved Gaddi (goat) breed bucks (6-9 months of age) kept on semi-intensive feeding management. The individuals (n = 20) representing the herd were selected and divided into two groups; group I (n = 10), clinically ill and group II (n = 10), sub clinically infected individuals. The clinical examination revealed anemia, emaciation and rise in body temperature of the individuals of group I as compared to group II...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29100304/germline-variations-at-jak2-tert-hbs1l-myb-and-mecom-and-the-risk-of-myeloproliferative-neoplasms-in-taiwanese-population
#6
Yi-Hao Chiang, Yu-Cheng Chang, Huan-Chau Lin, Ling Huang, Chun-Chia Cheng, Wei-Ting Wang, Hung-I Cheng, Nai-Wen Su, Caleb Gon-Shen Chen, Johnson Lin, Yi-Fang Chang, Ming-Chih Chang, Ruey-Kuen Hsieh, Wen-Chien Chou, Ken-Hong Lim, Yuan-Yeh Kuo
Germline variations at JAK2, TERT, HBS1L-MYB and MECOM have been found to associate with myeloproliferative neoplasms (MPNs) in European populations. Whether these germline variations are associated with MPNs in Taiwanese population is obscure. Here we aimed to evaluate the association of five germline variations (JAK2 46/1 haplotype tagged by rs12343867, JAK2 intron 8 rs12339666, TERT rs2736100, HBS1L-MYB rs9376092 and MECOM rs2201862) and the risk of MPNs in Taiwanese population. A total of 178 MPN patients (109 essential thrombocythemia, 54 polycythemia vera and 15 primary myelofibrosis) were enrolled into this study...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29093131/exploring-the-role-of-competition-induced-by-non-vaccine-serotypes-for-herd-protection-following-pneumococcal-vaccination
#7
G L Masala, M Lipsitch, C Bottomley, S Flasche
The competitive pressure from non-vaccine serotypes may have helped pneumococcal conjugate vaccines (PCVs) to limit vaccine-type (VT) serotype prevalence. We aimed to investigate if, consequently, the indirect protection of vaccines targeting most pneumococcal serotypes could fall short of the profound effects of current formulations. We compared three previously described pneumococcal models harmonized to simulate 20 serotypes with a combined pre-vaccination prevalence in children younger than 5-years-old of 40%...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29081590/a-recombinase-polymerase-amplification-based-assay-for-rapid-detection-of-african-swine-fever-virus
#8
Jianchang Wang, Jinfeng Wang, Yunyun Geng, Wanzhe Yuan
A recombinase polymerase amplification (RPA)-based method was developed for rapid and specific detection of African swine fever virus (ASFV), the etiologic agent of African swine fever, a devastating disease of swine. Primers and the exo probe targeting the conserved region of the P72 gene of ASFV were designed and the reaction was run on the Genie III scanner device. Using recombinant plasmid DNA containing the P72 gene as template, we showed that the amplified product could be detected in less than 10 min and that the detection limit was 10(2) copies DNA/reaction [same detection limit as real-time polymerase chain reaction (PCR)]...
October 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29080806/t-cell-mediated-immune-response-to-pneumococcal-conjugate-vaccine-pcv-13-and-tetanus-toxoid-vaccine-in-patients-with-moderate-to-severe-psoriasis-during-tofacitinib-treatment
#9
Kevin Winthrop, Neil Korman, William Abramovits, Scott T Rottinghaus, Huaming Tan, Annie Gardner, Geoffrey Mukwaya, Mandeep Kaur, Hernan Valdez
BACKGROUND: Psoriasis is often treated with immunomodulatory therapies that may affect immune response to common antigens. Tofacitinib is an oral Janus kinase inhibitor. OBJECTIVE: To characterize the effect of long-term exposure to tofacitinib 10 mg twice daily (BID) on T cell function in psoriasis patients. METHODS: Patients completing at least 3 months' continuous treatment with tofacitinib 10 mg BID were vaccinated with T cell-dependent vaccines (monovalent tetanus toxoid and 13-valent pneumococcal conjugate [PCV-13])...
October 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29062961/novel-polysaccharide-protein-conjugates-provide-an-immunogenic-13-valent-pneumococcal-conjugate-vaccine-for-s-%C3%A2-pneumoniae
#10
Allison E B Turner, Jonas E Gerson, Helen Y So, Daniel J Krasznai, Adrienne J St Hilaire, Donald F Gerson
Pneumonia remains the single leading cause of childhood death worldwide. Despite the commercial availability of multiple pneumococcal conjugate vaccines (PCVs), high dosage cost and supply shortages prevent PCV delivery to much of the developing world. The current work presents high-yield pneumococcal conjugates that are immunogenic in animals and suitable for use in human vaccine development. The 13-valent pneumococcal conjugate vaccine (PCV-13) investigated in this research incorporated serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F...
March 2017: Synthetic and Systems Biotechnology
https://www.readbyqxmd.com/read/29059101/prevalence-of-polypoidal-choroidal-vasculopathy-in-white-patients-with-exudative-age-related-macular-degeneration-systematic-review-and-meta-analysis
#11
Thomas D Lorentzen, Yousif Subhi, Torben L Sørensen
PURPOSE: Polypoidal choroidal vasculopathy (PCV) is a disease with significant inter-ethnical differences. In this study, we systematically review the literature on the prevalence of PCV in whites referred with a diagnosis of exudative age-related macular degeneration (AMD). METHODS: We searched PubMed, Embase, the Cochrane Library, and the Web of Science on 24 March, 2017 for studies evaluating the prevalence of PCV in white patients with exudative AMD. Data extraction and risk of bias assessments were performed in duplicate...
October 20, 2017: Retina
https://www.readbyqxmd.com/read/29031029/glutathione-peroxidase-activity-plasma-total-antioxidant-capacity-and-urinary-f2-isoprostanes-as-markers-of-oxidative-stress-in-anemic-dogs
#12
A Kendall, A Woolcock, A Brooks, G E Moore
BACKGROUND: Oxidative stress plays a role in the pathophysiology of several diseases and has been documented as a contributor to disease in both the human and veterinary literature. One at-risk cell is the erythrocyte, however, the role of oxidative stress in anemia in dogs has not been widely investigated. HYPOTHESIS/OBJECTIVE: Anemic dogs will have an alteration in the activity of glutathione peroxidase (GPx), a decrease in of total antioxidant capacity (TAC), and an increased concentration of urinary 15-F2 -isoprostanes (F2 -IsoP) when compared to healthy dogs...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29029063/impact-of-pneumococcal-vaccination-on-pneumonia-hospitalizations-and-related-costs-in-ontario-a-population-based-ecological-study
#13
Dara Lee Luca, Jeffrey C Kwong, Anna Chu, Beate Sander, Ryan O'Reilly, Allison J McGeer, David E Bloom
Background: In Ontario, Canada, pneumococcal conjugate vaccine (PCV) was approved for infants in 2001 and became part of the publicly funded routine immunization schedule in 2005. We assessed the population-level impact of PCV on pneumonia hospitalizations and related costs. Methods: We used the difference-in-differences (DD) approach to evaluate the impact of pneumococcal vaccination on pneumonia hospitalizations and related costs, using non-pneumonia hospitalization as the control condition...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29025108/hdl-cholesterol-levels-and-risk-of-age-related-macular-degeneration-a-multiethnic-genetic-study-using-mendelian-randomization
#14
Qiao Fan, Joseph C Maranville, Lars Fritsche, Xueling Sim, Chui Ming Gemmy Cheung, Li Jia Chen, Mathias Gorski, Kenji Yamashiro, Jeeyun Ahn, Augustinus Laude, Rajkumar Dorajoo, Tock Han Lim, Yik-Ying Teo, Robert O Blaustein, Nagahisa Yoshimura, Kyu-Hyung Park, Chi Pui Pang, E Shyong Tai, Chiea Chuen Khor, Tien Yin Wong, Heiko Runz, Ching-Yu Cheng
Background: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. Methods: We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 832 controls of European descent, together with 2219 cases and 5275 controls of Asian descent, using Mendelian randomization in three models...
September 12, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29017808/a-novel-technique-for-duplex-guided-office-based-interventions-for-patients-with-acute-arteriovenous-fistula-occlusion
#15
Afsha Aurshina, Enrico Ascher, Anil Hingorani, Natalie Marks
OBJECTIVE: The purpose of the study was to aggressively salvage acutely occluded arteriovenous fistulas (AVFs) using duplex imaging as the sole imaging modality for percutaneous transluminal angioplasty of acutely thrombosed AVF. METHODS: Over a period of 12 months, 14 patients with acute thrombosis of their AVFs underwent 18 procedures in a single center for AVF salvage. All 14 patients presented with chronic renal failure, and six were diabetic. All patients were treated under duplex guidance alone...
October 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29016756/the-electrocardiogram-as-a-predictor-of-successful-pharmacological-cardioversion-and-progression-of-atrial-fibrillation
#16
Stef Zeemering, Theo A R Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C A M Bekkers, Harry J G M Crijns, Ulrich Schotten
Aims: Non-invasive characterization of atrial fibrillation (AF) substrate complexity based on the electrocardiogram (ECG) may improve outcome prediction in patients receiving rhythm control therapies for AF. Multiple parameters to assess AF complexity and predict treatment outcome have been suggested. A comparative study of the predictive performance of complexity parameters on response to therapy and progression of AF in a large patient population is needed to standardize non-invasive analysis of AF...
July 26, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28990497/calr-jak2-and-mpl-mutation-status-in-argentinean-patients-with-bcr-abl1-negative-myeloproliferative-neoplasms
#17
Mara Jorgelina Ojeda, Irma Margarita Bragós, Karina Lucrecia Calvo, Gladis Marcela Williams, María Magdalena Carbonell, Arianna Flavia Pratti
OBJECTIVES: To establish the frequency of JAK2, MPL and CALR mutations in Argentinean patients with BCR-ABL1-negative  myeloproliferative neoplasms (MPN) and to compare their clinical and haematological features. METHODS: Mutations of JAK2V617F, JAK2 exon 12, MPL W515L/K and CALR were analysed in 439 Argentinean patients with BCR-ABL1-negative MPN, including 176 polycythemia vera (PV), 214 essential thrombocythemia (ET) and 49 primary myelofibrosis (PMF). RESULTS: In 94...
October 9, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28985807/age-related-macular-degeneration-is-polypoidal-choroidal-vasculopathy-recognized-and-treated
#18
Yufeng N Chen, Robert G Devenyi, Michael H Brent, Peter J Kertes, Kenneth T Eng, Carol E Schwartz, Radha P Kohly, David R Chow, David T Wong, Alan R Berger, Fil Altomare, Louis R Giavedoni, Rajeev H Muni, Alexander Soon, Patrick Yoo, Wai-Ching Lam
OBJECTIVE: To assess how polypoidal choroidal vasculopathy (PCV) is recognized and treated, and to assess whether treatment outcomes are different between Chinese and Caucasian Canadian patients with age-related macular degeneration (AMD). DESIGN: Retrospective chart review. PARTICIPANTS: 154 eyes from 135 Chinese patients and 2291 eyes from 1792 Caucasian patients who were newly diagnosed with either AMD or PCV and had more than 1 year of follow-up were included...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28961345/prediction-of-packed-cell-volume-after-whole-blood-transfusion-in-small-ruminants-and-south-american-camelids-80-cases-2006-2016
#19
D Luethy, D Stefanovski, R Salber, R W Sweeney
BACKGROUND: Calculation of desired whole blood transfusion volume relies on an estimate of an animal's circulating blood volume, generally accepted to be 0.08 L/kg or 8% of the animal's body weight in kilograms. OBJECTIVE: To use packed cell volume before and after whole blood transfusion to evaluate the accuracy of a commonly used equation to predict packed cell volume after transfusion in small ruminants and South American camelids; to determine the nature and frequency of adverse transfusion reactions in small ruminants and camelids after whole blood transfusion...
September 29, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28939140/clinical-presentation-management-and-prognostic-factors-of-idiopathic-systemic-capillary-leak-syndrome-a-systematic-review
#20
Tae Seong Eo, Kyung Ju Chun, Su Jung Hong, Ji Young Kim, I Re Lee, Keum Hwa Lee, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin
BACKGROUND: The idiopathic systemic capillary leak syndrome is a rare disease characterized by unexplained recurrent shock caused by capillary hyperpermeability. Because of the rarity of the disease, this disease has easily been misdiagnosed and evidence of efficacious agents used empirically is lacking. OBJECTIVE: To analyze the clinical and laboratory data, treatment modalities, and mortality rate of patients and to find contributing factors leading to mortality...
September 19, 2017: Journal of Allergy and Clinical Immunology in Practice
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