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https://www.readbyqxmd.com/read/28546150/six-year-outcomes-of-antivascular-endothelial-growth-factor-monotherapy-for-polypoidal-choroidal-vasculopathy
#1
Taiichi Hikichi
OBJECTIVE: To evaluate the 6-year outcomes of anti-VEGF (vascular endothelial growth factor) monotherapy for polypoidal choroidal vasculopathy (PCV). METHODS: The charts of 66 eyes of 66 patients with newly diagnosed, symptomatic, treatment-naive PCV were reviewed retrospectively. All patients were treated with 0.5 mg intravitreal ranibizumab (IVR) injections for 3 months followed by as-needed reinjections based on monthly examinations until 3 years after the first IVR injection...
May 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28542347/effectiveness-of-pneumococcal-vaccines-in-preventing-pneumonia-in-adults-a-systematic-review-and-meta-analyses-of-observational-studies
#2
Myint Tin Tin Htar, Anke L Stuurman, Germano Ferreira, Cristiano Alicino, Kaatje Bollaerts, Chiara Paganino, Ralf René Reinert, Heinz-Josef Schmitt, Cecilia Trucchi, Thomas Vestraeten, Filippo Ansaldi
INTRODUCTION: S. pneumoniae can cause a wide spectrum of diseases, including invasive pneumococcal disease and pneumonia. Two types of pneumococcal vaccines are indicated for use in adults: 23-valent pneumococcal polysaccharide vaccines (PPV23) and a 13-valent pneumococcal conjugate vaccine (PCV13). OBJECTIVE: To systematically review the literature assessing pneumococcal vaccine effectiveness (VE) against community-acquired pneumonia (CAP) in adults among the general population, the immunocompromised and subjects with underlying risk factors in real-world settings...
2017: PloS One
https://www.readbyqxmd.com/read/28533538/proteomic-analysis-of-jak2v617f-induced-changes-identifies-potential-new-combinatorial-therapeutic-approaches
#3
S Pearson, A J K Williamson, R Blance, T C P Somervaille, S Taylor, N Azadbakht, A D Whetton, A Pierce
In excess of 90% of patients with polycythemia vera express a mutated form of JAK2, JAK2V617F. Such aberrant proteins offer great potential for the treatment of these diseases however inhibitors to JAK2 have had limited success in the clinic in terms of curing the disease. To understand the effects of this oncogene in hematopoietic cells with the aim of improving treatment strategies we undertook a systematic evaluation of the effects of JAK2V617F expression using proteomics. The effects of JAK2V617F on over 5000 proteins and 2000 nuclear phosphopeptides sites were relatively quantified using either SILAC or eight channel iTRAQ mass spectrometry...
May 23, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28504566/influence-of-lactobacillus-reuteri-l26-biocenol%C3%A2-on-immune-response-against-porcine-circovirus-type-2-infection-in-germ-free-mice
#4
V Karaffová, T Csank, D Mudroňová, J Király, V Revajová, S Gancarčíková, R Nemcová, J Pistl, Š Vilček, M Levkut
Probiotic bacteria are frequently used for prevention of bacterial infections of the gastrointestinal tract, but there are only limited studies on their efficacy against viral gut infections in animals. The aim of this study was to investigate the effect of probiotic Lactobacillus reuteri L26 Biocenol(TM) on the innate and adaptive immune responses in germ-free Balb/c mice, experimentally infected by porcine circovirus type 2 (PCV2), which confers immunosuppressive effect. A total of 30 six-week-old female mice were divided into 3 groups and animals in experimental group LPCV (n=10) were inoculated with L...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28501455/exploring-the-acceptability-of-the-available-pneumococcal-conjugate-vaccines-in-canadian-health-care-professionals-and-immunization-experts
#5
Melissa Berman, Eve Dubé, Caroline Quach
BACKGROUND: In children, the 13 and 10-valent pneumoccocal conjugate vaccines (PCV13/10) are currently approved for the prevention of invasive pneumococcal disease (IPD). Acceptability is a key consideration in the implementation of a vaccine program and it is recognized that health professional's attitudes and opinions towards vaccines are independent predictors of the success of an immunization program. We aimed to survey the beliefs and attitudes for the two available PCVs in health care professionals and immunization experts...
June 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28499786/head-elevation-and-lateral-head-rotation-effect-on-facemask-ventilation-efficiency-randomized-crossover-trials
#6
Sayuri Matsunami, Nobuyasu Komasawa, Yuki Konishi, Toshiaki Minami
PURPOSE: We performed two prospective randomized crossover trials to evaluate the effect of head elevation or lateral head rotation to facemask ventilation volume. METHODS: In the first trial, facemask ventilation was performed with a 12-cm high pillow (HP) and 4-cm low pillow (LP) in 20 female patients who were scheduled to undergo general anesthesia. In the second trial, facemask ventilation was performed with and without lateral head rotation in another 20 female patients...
May 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28486544/serotype-distribution-of-streptococcus-pneumoniae-causing-invasive-disease-in-children-in-the-post-pcv-era-a-systematic-review-and-meta-analysis
#7
Evelyn Balsells, Laurence Guillot, Harish Nair, Moe H Kyaw
BACKGROUND: Routine immunisation with pneumococcal conjugate vaccines (PCV7/10/13) has reduced invasive pneumococcal disease (IPD) due to vaccine serotypes significantly. However, an increase in disease due to non-vaccine types, or serotype replacement, has been observed. Serotypes' individual contributions to IPD play a critical role in determining the overall effects of PCVs. This study examines the distribution of pneumococcal serotypes in children to identify leading serotypes associated with IPD post-PCV introduction...
2017: PloS One
https://www.readbyqxmd.com/read/28471973/a-randomized-comparison-of-volume-and-pressure-controlled-ventilation-in-children-with-the-i-gel-effects-on-peak-inspiratory-pressure-oropharyngeal-leak-pressure-and-gastric-insufflation
#8
Jin Ha Park, Ji Young Kim, Kyoungun Park, Hae Keum Kil
BACKGROUND: The i-gel provides good airway sealing but gastric insufflation may occur when peak inspiratory pressure (PIP) exceeds the sealing pressure of the i-gel without a gastric tube. Pressure-controlled ventilation (PCV) provides lower PIP compared with volume-controlled ventilation (VCV) and low PIP may reduce the incidence of gastric insufflation in children during positive pressure ventilation. This study was designed to evaluate PIP, oropharyngeal leak pressure, and gastric insufflation during VCV or PCV in children undergoing general anesthesia with i-gel without a gastric tube in situ...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28452991/focal-choroidal-excavation-morphological-features-and-clinical-correlation
#9
C Y Chung, S H Li, K K W Li
PurposeTo describe and correlate the morphological and clinical features of focal choroidal excavation (FCE).MethodsThis is a consecutive case series from the review of the 4436 optical coherence tomography scans performed by Kowloon East Cluster Ophthalmic Service from 1 August 2014-31 January 2016. Statistical analysis was performed on SPSS 18.0 (SPSS, Chicago, IL, USA). A significance level of P<0.05 was taken.ResultsAll 16 patients with FCE had unilateral involvement. The mean age of diagnosis was 52...
April 28, 2017: Eye
https://www.readbyqxmd.com/read/28429115/comparison-of-the-tolerability-of-newly-introduced-childhood-vaccines-in-the-netherlands
#10
Jeanet M Kemmeren, Nicoline At van der Maas, Hester E de Melker
In 2011, the 7-valent conjugated pneumococcal vaccine (PCV7) was replaced by the 10-valent vaccine (PCV10) and universal hepatitis B vaccination has been introduced in the Netherlands. A questionnaire study was conducted to assess the tolerability of DTaP-IPV-Hib + PCV7 (PCV7-cohort), DTaP-IPV-Hib + PCV10 (PCV10-cohort), and DTaP-IPV-Hib-HepB + PCV10 (HepB-cohort). Parents were asked to report in questionnaires local reactions and systemic adverse events (AEs) before and after vaccination of their infant at 2, 3, 4, and 11 months of age...
April 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28428893/characteristics-and-racial-variations-of-polypoidal-choroidal-vasculopathy-in-tertiary-centers-in-the-united-states-and-united-kingdom
#11
Tarek Alasil, Nelida Munoz, Pearse A Keane, Adnan Tufail, Patrick A Coady, Eduardo Novais, Talisa E de Carlo, Caroline R Baumal, Nadia K Waheed, Jay S Duker, Ron A Adelman
PURPOSE: To evaluate the characteristics and racial variations amongst patients with polypoidal choroidal vasculopathy (PCV) in the United States and the United Kingdom. METHODS: Fundus photos and indocyanine green angiography images were evaluated in a multicenter retrospective study to establish the diagnosis of PCV. Visual acuity (VA) was recorded in ETDRS letter count. RESULTS: Eighty eyes of 71 PCV patients (average age of 69.4 ± 10...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28420390/a-novel-viewrna-in-situ-hybridization-method-for-the-detection-of-the-dynamic-distribution-of-classical-swine-fever-virus-rna-in-pk15-cells
#12
COMPARATIVE STUDY
Qianyi Zhang, Lu Xu, Yujie Zhang, Tuanjie Wang, Xingqi Zou, Yuanyuan Zhu, Yan Zhao, Cui Li, Kai Chen, Yongfang Sun, Junxiang Sun, Qizu Zhao, Qin Wang
BACKGROUND: Classical swine fever (CSF) is a highly contagious fatal infectious disease caused by classical swine fever virus (CSFV). A better understanding of CSFV replication is important for the study of pathogenic mechanism of CSF. With the development of novel RNA in situ Hybridization method, quantitatively localization and visualization of the virus RNA molecular in cultured cell or tissue section becomes very important tool to address these pivotal pathogenic questions. In this study, we established ViewRNA ISH method to reveal the dynamic distribution of CSFV RNA in PK15 cells...
April 18, 2017: Virology Journal
https://www.readbyqxmd.com/read/28419083/pneumococcal-vaccination-and-efficacy-in-patients-with-heterotaxy-syndrome
#13
Pei-Lan Shao, Mei-Hwan Wu, Jou-Kou Wang, Hui-Wen Hsu, Li-Min Huang, Shuenn-Nan Chiu
BACKGROUND: Pneumococcal vaccines, including pneumococcal polysaccharide vaccine (PPV) and pneumococcal conjugated vaccine (PCV), are important in preventing invasive pneumococcal disease. We analyzed the pneumococcal vaccination rate, efficacy and durability in patients with heterotaxy. METHODS: All patients with heterotaxy and CCHD who were followed at our institution between 2010 and 2015 were included. Pneumococcal vaccine status and geometric mean concentration (GMC) of serotypes 6B, 14, 19F, and 23F were analyzed...
April 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28401328/equine-colic-clinical-epidemiology-and-associated-risk-factors-in-and-around-debre-zeit
#14
Yonas Worku, Workneh Wondimagegn, Nigatu Aklilu, Zerihun Assefa, Ayele Gizachew
A prospective study was conducted to describe clinical epidemiology of equine colic in the Society for Protection of Animal Abroad and Donkey Sanctuary Project Clinic, at Debre Zeit, Ethiopia, from November 2014 to April 2015. The objectives were to describe clinical epidemiology of equine colic, to characterize the main types of equine colic, and to determine the major risk factors associated with equine colic. The method which was used in the study was attending clinical case of equine and assessing physiological parameters, fecal egg count, abdominal sounds, and rectal examination as well as questioner interviewing of the owners...
April 11, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28391070/can-haemonchus-placei-primary-infected-na%C3%A3-ve-lambs-withstand-haemonchus-contortus-infections
#15
Regina Celis Pereira Reiniger, Luciana Laitano Dias de Castro, Magda Vieira Benavides, Maria Elisabeth Aires Berne
An experiment was conducted with the objective of evaluating whether a 5000 L3 larvae Haemonchus placei primary infection, a less pathogenic parasite species for sheep, could attenuate highly pathogenic Haemonchus contortus infections in lambs. Thirty nine 6-month-old lambs were divided in three primary-infection groups: (HcPI) H. contortus-primary infected lambs, (HpPI) H. placei-primary infected lambs, and (CTRL) non-infected control lambs. Later, these same individuals, then aged 10-month old, were cross challenged with Haemonchus parasite species, creating four groups: HcPI challenged with H...
February 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28384009/incidence-and-timing-of-the-first-recurrence-in-neovascular-age-related-macular-degeneration-comparison-between-ranibizumab-and-aflibercept
#16
Jae Hui Kim, Young Suk Chang, Dong Won Lee, Chul Gu Kim, Jong Woo Kim
PURPOSE: To compare the incidence and timing of first recurrence between patients who were treated with ranibizumab and aflibercept in neovascular age-related macular degeneration (AMD). METHODS: This retrospective study included 120 patients who received the diagnosis of treatment-naive typical neovascular AMD or polypoidal choroidal vasculopathy (PCV) and were treated using either ranibizumab (n = 73) or aflibercept (n = 47). Recurrence within 10 months of the third injection was compared between the 2 treatment groups...
April 6, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28380511/association-between-famacha-scores-and-fecal-egg-counts-in-katahdin-lambs
#17
D R Notter, J M Burke, J E Miller, J L M Morgan
The FAMACHA system was introduced to the U.S. just over 10 yr ago to allow selective deworming of lambs with anemia associated with and retard the development of anthelmintic resistance. The FAMACHA system was initially developed as a predictor of packed cell volume (PCV), but correlations between FAMACHA and fecal egg counts (FEC) have also been reported. It is important to understand factors that influence FAMACHA scores among farms to improve management of gastrointestinal nematodes. The objectives of this study were therefore to quantify associations between FAMACHA scores, FEC, BW, and age in Katahdin lambs at 2 different measurement times in 8 flocks in the eastern U...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28372533/panel-6-vaccines
#18
Melinda M Pettigrew, Mark R Alderson, Lauren O Bakaletz, Stephen J Barenkamp, Anders P Hakansson, Kevin M Mason, Johanna Nokso-Koivisto, Janak Patel, Stephen I Pelton, Timothy F Murphy
Objective To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources PubMed database of the National Library of Science. Review Methods We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28370365/monocytosis-in-polycythemia-vera-clinical-and-molecular-correlates
#19
Daniela Barraco, Sonia Cerquozzi, Naseema Gangat, Mrinal M Patnaik, Terra Lasho, Christy Finke, Curtis A Hanson, Rhett P Ketterling, Animesh Pardanani, Ayalew Tefferi
Monocytosis (absolute monocyte count, AMC ≥1 x 10(9) /L) might accompany a spectrum of myeloid neoplasms, other than chronic myelomonocytic leukemia (CMML). In the current study, we examined the prevalence, laboratory and molecular correlates, and prognostic relevance of monocytosis in polycythemia vera (PV). Among 267 consecutive patients with World Health Organization (WHO)-defined PV, 55 (21%) patients displayed an AMC of ≥1 x 10(9) /L and 18 (7%) an AMC of ≥1.5 x 10(9) /L. In general, PV patients with monocytosis were significantly older and displayed higher frequencies of leukocytosis (81% vs 50% at AMC ≥1 x 10(9) /L) and TET2/SRSF2 mutations (57%/29% vs 19%/1% at AMC≥1...
March 28, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28352230/lead-induced-hepato-renal-damage-in-male-albino-rats-and-effects-of-activated-charcoal
#20
Samuel J Offor, Herbert O C Mbagwu, Orish E Orisakwe
Lead is a multi-organ toxicant implicated in various cancers, diseases of the hepatic, renal, and reproductive systems etc. In search of cheap and readily available antidote this study has investigated the role of activated charcoal in chronic lead exposure in albino rats. Eighteen mature male albino rats were used, divided into three groups of six rats per group. Group 1 (control rats) received deionised water (10 ml/kg), group 2 was given lead acetate solution 60 mg/kg and group 3 rats were given lead acetate (60 mg/kg) followed by Activated charcoal, AC (1000 mg/kg) by oral gavage daily for 28 days...
2017: Frontiers in Pharmacology
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