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pcv 10

Xiuting Mo, Ruoyan Gai Tobe, Xiaoyan Liu, Rintaro Mori
BACKGROUND: Each year in China, approximately 700,000 children under 5 years old are diagnosed with pneumonia, and 30,000 die of the disease. Although 7-valent pneumococcal conjugate vaccine (PCV-7) and 23-valent pneumococcal polysaccharide vaccine (PPV-23) are available in China, the costs are borne by the consumer, resulting in low coverage for PCV-7. We aimed to conduct a simulation study to assess the cost-effectiveness and health benefits of PCV-7, 13-valent pneumococcal conjugate vaccine (PCV-13) and PPV-23 to prevent childhood pneumonia and other vaccine-preventive diseases in China...
November 2016: Pediatric Infectious Disease Journal
Frederico F Vaz, Rosangela Locatelli-Dittrich, Olair C Beltrame, Elenise A B Sipinski, Maria C Abbud, Rafael M Sezerban
BACKGROUND: The Red-Tailed Amazon parrot (Amazona brasiliensis) is an endangered species of the Psittaciformes. There is little information about hematologic and biochemical variables of this species. OBJECTIVES: The purpose of this study was to determine hematologic and biochemical RIs for free-living A brasiliensis nestlings on Rasa Island, Paraná, Brazil, and to compare the results between sexes. METHODS: Thirty-seven parrots were taken from their nests and physically restrained for clinical examination and blood collection...
October 4, 2016: Veterinary Clinical Pathology
Maria-Cristina de C Brandileone, Rosemeire C Zanella, Samanta C G Almeida, Angela P Brandao, Ana F Ribeiro, Telma-Regina M P Carvalhanas, Helena Sato, Ana-Lúcia Andrade, Jennifer R Verani
In March 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in the routine infant immunization program using a 4-dose schedule and catch-up for children <23months. We investigated PCV10 effect on nasopharyngeal carriage with vaccine-type Streptococcus pneumoniae (Spn) and non-typeable Haemophilus influenzae (NTHi) among children in São Paulo city. Cross-sectional surveys were conducted in 2010 (baseline) and 2013 (post-PCV10). Healthy PCV-naïve children aged 12-23months were recruited from primary health centers during immunization campaigns...
September 28, 2016: Vaccine
E C McKenzie, L V Eyrich, M E Payton, S J Valberg
A previous report suggests a substantial incidence of exertional rhabdomyolysis (ER) in Arabian horses performing endurance racing. This study compared formalin histopathology and clinical and metabolic responses to a standardised field exercise test (SET) between Arabians with and without ER. Arabian horses with (n = 10; age 15.4 ± 5.6 years) and without (n = 9; 12.9 ± 6.1 years) prior ER were stall-rested for 24-48 h, after which paired ER and control horses were fitted with a telemetric ECG and performed a 47 min submaximal SET...
October 2016: Veterinary Journal
Kassa Shawle, Mengistu Urge, Getachew Animut
BACKGROUND: Frequent use of antibiotics to stimulate growth and health of animals leads to the development of antibiotic-resistant populations of microorganisms. In this context, alternatives like herbs and spices to antibiotics are of importance, as they are natural products. Therefore, the present experiment was designed to evaluate the performance, carcass traits, hematology and serum biochemical parameters of broilers fed ration containing varying levels of Lepidium satvium (Garden cress) seed powder as feed additive up to the age of 42 days...
2016: SpringerPlus
Sanath Krishna Muliya, Mudraje Narayana Bhat
AIM: To study the hematology and serum biochemistry parameters of Indian spectacled cobra (Naja naja) and Indian rat snake (Ptyas mucosa) and to evaluate the differences in the same between captive and wild populations. MATERIALS AND METHODS: Animals were categorized into four groups, viz., wild Indian spectacled cobra (n=10), wild Indian rat snakes (n=10), captive Indian spectacled cobra (n=10), and captive Indian rat snake (n=10). The snakes were restrained with restraint tubes, and 2 ml of blood was collected from either heart or ventral coccygeal vein...
August 2016: Veterinary World
Isaiah O Ademola, Paul O Odeniran
CONTEXT: Control of African trypanosomiasis relies on chemotherapy, but the development of resistance and the problem of drug residues require research for alternatives. Triterpenes and phenolics, the major constituents of Pleurotus sajor-caju (Fr.) Singer (Pleurotaceae), are reported to be effective against trypanosomiasis. OBJECTIVE: Trypanocidal effect of whole Pleurotus sajor-caju aqueous extract was investigated in vivo against Trypanosoma congolense. MATERIALS AND METHODS: Mice (25-32 g) were divided into seven groups of six animals...
September 21, 2016: Pharmaceutical Biology
Dana L Shuey, Julian Oliver, Gongfu Zhou, Alan Roberts
Ruxolitinib is a selective and potent inhibitor of Janus kinase (JAK) 1 and JAK2. It is approved for the treatment of patients with intermediate or high-risk myelofibrosis, or those with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea. To investigate its carcinogenic potential, ruxolitinib was administered by oral gavage once daily to Tg.rasH2 mice for 6 months at doses of 15, 45 or 125 mg/kg/day, and to Sprague-Dawley (Crl:CD) rats for 2 years at 10, 20 or 60 mg/kg/day...
September 16, 2016: Regulatory Toxicology and Pharmacology: RTP
Ermias Mergia, Workineh Shibeshi, Getachew Terefe, Tilahun Teklehaymanot
BACKGROUND: African Trypanosomiasis is a neglected tropical disease with a large impact on the livelihood of the rural poor in Sub-Saharan Africa. The available drugs for managing this disease are old, expensive and are facing the problem of drug resistance. Thus, the aim of this study was to evaluate in vivo antitrypanosomal efficacy of aqueous and absolute methanol leaf extracts of Verbascum sinaiticum Benth. against Trypanosoma congolense field isolate. METHODS: Verbascum sinaiticum (Local name 'qetetina') is a biennial plant, and 60-150 cm tall...
2016: BMC Complementary and Alternative Medicine
Kalyan Sarma, H Prasad, Gunjan Das, P Behera, S K Behera, J B Rajesh, S K Borthakur
To know the prevalence of theileriosis infection, haemato-biochemical alteration and efficacy of Oxytetracycline in combination with Diaminazene aceturate injection against theileriosis in Lushai hill district of Mizoram; fifty five cross bred cattle were screened during July, 2013 to November, 2013. The prevalence of tropical theileriosis was 9.09 % based on blood smear examination. Clinical features of the disease were manifested by high rise of body temperature 104.8 ± 1.2 °F, lymphadenopathy, inability to walk, anorexia, listlessness, moderate anaemia, nasal discharge, edema of eye and corneal opacity...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Seongyong Jeong, Min Sagong
BACKGROUND/AIMS: To compare the short-term efficacy of intravitreal aflibercept treatment according to the subtypes of polypoidal choroidal vasculopathy (PCV) based on indocyanine green angiography (ICGA). METHODS: Twenty-nine patients (29 eyes) with treatment-naïve subfoveal PCV were consecutively enrolled in this institutional study. The subjects were classified into two subtypes (type 1, polypoidal choroidal neovascularisation (CNV), 16 eyes; and type 2, idiopathic PCV, 13 eyes) based on the presence or absence of both feeder and draining vessels on ICGA...
September 5, 2016: British Journal of Ophthalmology
Ilaria Ceglia, Amylou C Dueck, Francesca Masiello, Fabrizio Martelli, Wu He, Giulia Federici, Emanuel F Petricoin, Ann Zeuner, Camelia Iancu-Rubin, Rona Weinberg, Ronald Hoffman, John Mascarenhas, Anna Rita Migliaccio
To assess the role of abnormal transforming growth factor-beta (TGF-β) signaling in the pathogenesis of primary myelofibrosis (PMF), the effects of the TGF-β receptor-1 kinase inhibitor SB431542 on ex vivo expansion of hematopoietic cells in cultures from patients with JAK2V617(+)-polycythemia vera (PV) or PMF (JAK2V617F(+), CALRpQ365f(+), or unknown) and from normal sources (adult blood, AB, or cord blood, CB) were compared. In cultures of normal sources, SB431542 significantly increased by 2.5-fold the number of progenitor cells generated by days 1-2 (CD34(+)) and 6 (colony-forming cells) (CB) and that of precursor cells, mostly immature erythroblasts, by days 14-17 (AB and CB)...
August 31, 2016: Experimental Hematology
R K Al-Rukibat, M B Al-Zghoul, W M Hananeh, M Q Al-Natour, E A Abu-Basha
The effects of thermal manipulation (TM) at 38.5°C and 40°C for 6 h at embryonic day (ED) 16, 9 h at ED 17, and 12 h at ED 18 on body weight (BW) and cloacal body temperature (T(b)) during the first wk and later at post-hatch d 10, 14, 21, 28, and 42 were evaluated. Furthermore, chicks' ability to cope with a thermal challenge (TC; 41°C for 6 h) at post-hatch d 14 and 42 was also evaluated. A chick's response to TC was measured by determining the cloacal body temperature; the plasma thyroid hormones (thyroxin (T4) and triiodothyronine (T3)); the packed cell volume (PCV); the heterophil (H), lymphocyte (L), monocyte, basophil, and eosinophil percentages; and the heterophil-to-lymphocyte ratios (H/L)...
September 1, 2016: Poultry Science
E Mitsi, A M Roche, J Reiné, T Zangari, J T Owugha, S H Pennington, J F Gritzfeld, A D Wright, A M Collins, S van Selm, M I de Jonge, S B Gordon, J N Weiser, D M Ferreira
The ability of pneumococcal conjugate vaccine (PCV) to decrease transmission by blocking the acquisition of colonization has been attributed to herd immunity. We describe the role of mucosal immunoglobulin G (IgG) to capsular polysaccharide (CPS) in mediating protection from carriage, translating our findings from a murine model to humans. We used a flow cytometric assay to quantify antibody-mediated agglutination demonstrating that hyperimmune sera generated against an unencapsulated mutant was poorly agglutinating...
August 31, 2016: Mucosal Immunology
Temitope A Ajadi, Oladele S Gazal
Welfare concerns are growing regarding surgical castration (SC) in pets, necessitating the need for non-surgical alternatives. Administration of vaccines against gonadotropins releasing hormone (GnRH) have been reported as alternative to SC. This study determined the effect of surgical and immunological castrations (IC) on complete blood counts, plasma testosterone (T), luteinizing hormone (LH) concentrations and ejaculate characteristics in mongrel dogs. Ten intact male dogs were randomly divided into two groups (A & B)...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
J A Findley, S Salem, R Burgess, D C Archer
REASONS FOR PERFORMING STUDY: Relaparotomy may be required to investigate and manage complications that occur following surgical management of colic. OBJECTIVES: To report factors associated with survival following relaparotomy. STUDY DESIGN: Retrospective cohort study. METHODS: Records of horses that had undergone exploratory laparotomy for treatment of colic over a 10-year period (2002-2012) and had undergone relaparotomy <8 weeks following the initial surgery were reviewed...
August 27, 2016: Equine Veterinary Journal
María J Forzán, Todd G Smith, Raphaël V Vanderstichel, Natacha S Hogan, Cornelia V Gilroy
BACKGROUND: Although the Wood Frog, Rana sylvatica, is used in research on infectious diseases of amphibians, hematologic RIs or response to infection have not been established. OBJECTIVES: The purpose of the study was to determine hematologic RIs for adult Wood Frogs and alterations associated with infection with Frog Virus 3 (FV3, Ranavirus sp.). METHODS: Blood was collected from 40 wild-caught adult Wood Frogs that had been in captivity for 6 months...
September 2016: Veterinary Clinical Pathology
Young June Choe, Hoan Jong Lee, Hyunju Lee, Chi Eun Oh, Eun Young Cho, Jae Hong Choi, Hyun Mi Kang, In Ae Yoon, Hyun Joo Jung, Eun Hwa Choi
BACKGROUND: This study was performed to assess the serotype distribution and antibiotic nonsusceptibility of pneumococcal carriage isolates from children in Korea following the introduction of extended-valency pneumococcal conjugate vaccines (PCVs). METHODS: From April to June 2014, nasopharyngeal swabs were collected from children who were attending daycare centers in Korea. The collection was conducted in accordance with the World Health Organization Pneumococcal Carriage Working Group standards...
September 14, 2016: Vaccine
G Thirumalaisamy, M R Purushothaman, P Vasantha Kumar, P Selvaraj
AIM: The study was undertaken to find out the effect of feeding cottonseed meal (CSM) on performance of hematological and serum biochemical parameters in broiler birds. MATERIALS AND METHODS: A 6-week biological trial was carried out with 432-day-old Cobb 400 broiler chicks distributed to nine experimental diets with six replicates, each containing eight chicks. The experimental diets were formulated based on total amino acids (BTAA) or based on digestible amino acids (BDAA) with or without iron supplementation with two levels of CSM (2% and 4%) and control diet based on maize - soybean...
July 2016: Veterinary World
Sarocha Chootipongchaivat, Varit Chantarastapornchit, Wantanee Kulpeng, Joyce Anne Ceria, Niña Isabelle Tolentino, Yot Teerawattananon
OBJECTIVE: Implementing national-level vaccination programs involves long-term investment, which can be a significant financial burden, particularly in resource-limited settings. Although many studies have assessed the economic impacts of providing vaccinations, evidence on the positive and negative implications of human resources for health (HRH) is still lacking. Therefore, this study aims to estimate the HRH impact of introducing pneumococcal conjugate vaccine (PCV) using a model-based economic evaluation...
September 14, 2016: Vaccine
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