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Kathleen M Morrow, Abbey Rose Tedford, M Sabrina Pankey, Michael P Lesser
Symbiotic associations with subcuticular bacteria (SCB) have been identified and studied in many echinoderms, including the SCB of the brooding brittle star, Amphipholis squamata. Previous studies on the SCB of A. squamata placed the isolated bacterium, designated as AS1, in the genus Vibrio (Gammaproteobacteria), but subsequent studies suggested that the SCB of echinoderms belong to the Alphaproteobacteria. This study examines the taxonomic composition of SCB associated with A. squamata from the Northwest Atlantic using the 16S rRNA gene and next generation sequencing (NGS)...
February 19, 2018: FEMS Microbiology Ecology
Alexander Kudryavtsev, Ekaterina Volkova
We isolated and described a brackish-water amoeba, Clydonella sawyeri n. sp. (Amoebozoa, Vannellida), from the littoral habitat in Kandalaksha Bay (The White Sea, northwestern Russia). Morphology of this amoeba corresponds to the initially proposed diagnosis of the genus Clydonella Sawyer, 1975, although it is sufficiently different from other described species of this genus to warrant a distinct species designation. Phylogenetic analysis based on the small-subunit rRNA gene shows that this species is closely related to the two previously studied ATCC strains identified as Clydonella sp...
February 6, 2018: European Journal of Protistology
María Del Carmen Ortuño-Costela, Ana Moreno-Izquierdo, Rafael Garesse, M Esther Gallardo
We have generated a human iPSC line, IISHDOi002-A, from commercial primary normal human dermal fibroblasts belonging to an African mitochondrial haplogroup (L3), and with a 46, XY/47, XYY mosaicism. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4 and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.
February 14, 2018: Stem Cell Research
Mehtap Danismazoglu, Remziye Nalcacioglu, Hacer Muratoglu, Zihni Demirbag
Entomopoxviruses are an important group of viruses infecting only insects. They belong to Poxviridae which infect both invertebrates and vertebrates, including humans. Protein kinases are known to have roles at virus morphogenesis, host selectivity, the regulation of cell division and apoptosis in some vertebrate poxviruses. In this study, 2 protein kinases (PKs) (AMV153 and AMV197) of Amsacta moorei entomopoxvirus (AMEV) were investigated for the interactions among 230 viral proteins using yeast two-hybrid system (Y2H)...
February 19, 2018: Virus Research
Federico Soria, Esther Morcillo, Alvaro Serrano, Alberto Budia, Inmaculada Fernández, Tomás Fernández-Aparicio, Francisco M Sanchez-Margallo
OBJECTIVES: The purpose is to determine the effects in urinary tract of a new antireflux biodegradable ureteral stent. MATERIAL AND METHODS: Thirty six ureters belonging to 24 pigs were used. The study began with an endoscopic, nephrosonographic and fluoroscopic assessment. Three study groups of n=12 ureters were then specified. In Group I, a biodegradable antireflux stent (BDG-ARS) was inserted in the right ureter of 12 pigs. Group II was comprised by the left ureter of the same animals, in which a double pigtail stent was placed for 6 weeks...
February 19, 2018: Urology
Priyanka Mukherjee, Amarjit Karam, Luit Barkalita, Prabodh Borah, Amit Kr Chakraborty, Samir Das, Kekungo Puro, Rajkumari Sanjukta, Sandeep Ghatak, Ingudam Shakuntala, Ram Gopal Laha, Arnab Sen, Indu Sharma
Porcine Circovirus type-2 (PCV-2) is considered as a major threat to the piggery sector in India. To ascertain the epidemiological status and infection level of PCV2, a pilot study was undertaken to find out the prevalence of PCV2 in swine population by ELISA and PCR in the interior and border areas of Meghalaya which includes the area where accessibility and medical aid is a rare phenomenon. A total of 249 serum samples were collected from October 2014 to February 2016 from three divisions of Meghalaya: Khasi, Jaintia and Garo Hills Divisions...
February 19, 2018: Acta Tropica
I C Reis, C T Codeço, D C P Câmara, J J Carvajal, G R Pereira, E C Keppeler, N A Honório
The genus Anopheles encompasses several species considered as vectors of human infecting Plasmodium. Environmental changes are responsible for behavior changes in these vectors and therefore the pattern of malaria transmission. To better understand the dynamics of malaria transmission, this study aimed at identify the species of adult anophelines found in a malaria endemic urban area of the Amazon region, Mâncio Lima, located in the Acre State Brazil. Using Shannon-type light traps installed at 11 collection points near fish ponds, a total of 116 anophelines were collected belonging to nine species...
February 22, 2018: Neotropical Entomology
Sanjana Negi, Himanshu Tak, T R Ganapathi
MusaSNAC1 function in H2 O2 mediated stomatal closure and promote drought tolerance by directly binding to CGT[A/G] motif in regulatory region of multiple stress-related genes. Drought is a abiotic stress-condition, causing reduced plant growth and diminished crop yield. Guard cells of the stomata control photosynthesis and transpiration by regulating CO2 exchange and water loss, thus affecting growth and crop yield. Roles of NAC (NAM, ATAF1/2 and CUC2) protein in regulation of stress-conditions has been well documented however, their control over stomatal aperture is largely unknown...
February 22, 2018: Plant Molecular Biology
Ming-Wei Lai, Ruey-Fen Liou
Plant cell walls are pivotal battlegrounds between microbial pathogens and their hosts. To penetrate the cell wall and thereby to facilitate infection, microbial pathogens are equipped with a wide array of cell wall-degrading enzymes to depolymerize the polysaccharides in the cell wall. However, many of these enzymes and their role in the pathogenesis of microbial pathogens are not characterized, especially those from Oomycetes. In this study, we analyzed the function of four putative endo-beta-1,4-xylanase-encoding genes (ppxyn1-ppxyn4) from Phytophthora parasitica, an oomycete plant pathogen known to cause severe disease in a wide variety of plant species...
February 22, 2018: Current Genetics
Hossein Fahimi, Mahshid Mohammadipour, Hamed Haddad Kashani, Farshid Parvini, Majid Sadeghizadeh
Dengue viruses are emerging mosquito-borne pathogens belonging to Flaviviridae family which are transmitted to humans via the bites of infected mosquitoes Aedes aegypti and Aedes albopictus. Because of the wide distribution of these mosquito vectors, more than 2.5 billion people are approximately at risk of dengue infection. Dengue viruses cause dengue fever and severe life-threatening illnesses as well as dengue hemorrhagic fever and dengue shock syndrome. All four serotypes of dengue virus can cause dengue diseases, but the manifestations are nearly different depending on type of the virus in consequent infections...
February 22, 2018: Applied Microbiology and Biotechnology
Seth S Leopold
No abstract text is available yet for this article.
February 21, 2018: Clinical Orthopaedics and related Research
Kate Prichard, David Campkin, Nicholas O'Brien, Atsushi Kato, George W J Fleet, Michela I Simone
3,4,5-Trihydroxypiperidines belong to the family of 1,5-dideoxy-1,5-iminosugar natural products and are structural analogues of pentose monosaccharides in the pyranose form. The biological activities of these apparently structurally simple molecules and their N- and O-alkylated and -arylated derivatives are no less remarkable than their C-6 hydroxymethyl counterparts of the hexoses (such as 1-deoxynojirimycin, DNJ). Their biological profiles indicate that the hydroxymethyl branch is crucial to neither potency nor selectivity, with O-alkylation demonstrated to produce exquisite selectivity extending beyond glycosidase inhibition, to immunosuppressant and antibacterial activities...
February 22, 2018: Chemical Biology & Drug Design
Young-Ok Kim, In-Suk Park, Sooyeon Park, Bo-Hye Nam, Dong-Gyun Kim, Sung-Min Won, Jung-Hoon Yoon
A Gram-stain-negative, aerobic, non-motile and coccoid or ovoid bacterial strain, designated LB2T , was isolated from a Korean foodstuff, salted pollack. Strain LB2T grew optimally at 25-30 °C, at pH 7.0-8.0 and in the presence of 0-2.0 % (w/v) NaCl. Phylogenetic trees based on 16S rRNA gene sequences showed that strain LB2T belonged to the genus Paracoccus, coherently clustering with the type strain of Paracoccus sulfuroxidans. Strain LB2T exhibited 16S rRNA gene sequence similarity values of 98.0 and 97...
February 22, 2018: International Journal of Systematic and Evolutionary Microbiology
Mariela Martínez Gómez, Filipe Vieira Santos de Abreu, Alexandre Araujo Cunha Dos Santos, Iasmim Silva de Mello, Marta Pereira Santos, Ieda Pereira Ribeiro, Anielly Ferreira-de-Brito, Rafaella Moraes de Miranda, Marcia Gonçalves de Castro, Mario Sergio Ribeiro, Roberto da Costa Laterrière Junior, Shirlei Ferreira Aguiar, Guilherme Louzada Silva Meira, Deborah Antunes, Pedro Henrique Monteiro Torres, Daiana Mir, Ana Carolina Paulo Vicente, Ana Carolina Ramos Guimarães, Ernesto Raul Caffarena, Gonzalo Bello, Ricardo Lourenço-de-Oliveira, Myrna Cristina Bonaldo
Southeastern Brazil has been suffering a rapid expansion of a severe sylvatic yellow fever virus (YFV) outbreak since late 2016, which has reached one of the most populated zones in Brazil and South America, heretofore a yellow fever-free zone for more than 70 years. In the current study, we describe the complete genome of 12 YFV samples from mosquitoes, humans and non-human primates from the Brazilian 2017 epidemic. All of the YFV sequences belong to the modern lineage (sub-lineage 1E) of South American genotype I, having been circulating for several months prior to the December 2016 detection...
February 22, 2018: Journal of General Virology
Young-Ok Kim, In-Suk Park, Sooyeon Park, Bo-Hye Nam, Dong-Gyun Kim, Seok-Gwan Choi, Jin-Woo Bae, Jung-Hoon Yoon
A Gram-stain-negative, non-motile, aerobic and rod-shaped bacterial strain, designated RA3-3-1T , was isolated from splendid alfonsino (Beryxsplendens) collected from the North Pacific Ocean. Strain RA3-3-1T grew optimally at 25 °C, at pH 7.0-8.0 and in the presence of 1.0-3.0 % (w/v) NaCl. The neighbour-joining phylogenetic tree based on 16S rRNA gene sequences revealed that strain RA3-3-1T belonged to the genus Bizionia, clustering with the type strain of Bizionia fulviae. Strain RA3-3-1T exhibited 16S rRNA gene sequence similarities of 98...
February 22, 2018: International Journal of Systematic and Evolutionary Microbiology
Anne Hudon, Émilie Blackburn, Maude Laliberté, Kadija Perreault, Barbara Mazer, Debbie Ehrmann Feldman, Bryn Williams-Jones, Matthew Hunt
Ethics education is the cornerstone of professional practice, fostering knowledge and respect for core ethical values among healthcare professionals. Ethics is also a subject well-suited for interprofessional education and collaboration. However, there are few initiatives to gather experiences and share resources among ethics educators in rehabilitation. We thus undertook a knowledge exchange project to: 1) share knowledge about ethics training across Canadian occupational and physical therapy programs, and 2) build a community of educators dedicated to improving ethics education...
February 22, 2018: Journal of Interprofessional Care
Wang Ke, Ni Qing-Xiang, Yu Xiang-Hua, Chen Yi, Wei Jing-Jiao, Zhu Shan-Bing
The three death cases of falciparum malaria in Wenzhou City were all imported from Africa. One patient died on 10 January 2007 because of severe clinical symptoms after hospitalization. The second case was initially misdiagnosed as influenza in primary health and medical institution. The patient's condition quickly worsened and died of Plasmodium falciparum infection on 5 March 2011. The third patient belonged to "non-identity" person, and there were no detailed information and epidemiological history on admission, which resulted in the delayed diagnosis, disease exacerbation and death...
December 5, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Zhou Wei, Yang Jun-Qi
The Rho subfamily of GTPase belongs to the Ras superfamily of small GTP binding protein, it is a nucleotide dependent protein, which plays a "molecular switch" function in the signal transduction process and control of numerous signaling pathways. Rho protein has many biological effects on cytoskeleton or target proteins as a signal converter in signal transduction, such as the regulation of membrane transport function, cell migration, cell adhesion, and cell proliferation. It also plays a very important role in the infection and immune inflammation of the body...
December 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Mohammad Pourkheirandish, Hiroyuki Kanamori, Jianzhong Wu, Shun Sakuma, Frank R Blattner, Takao Komatsuda
Wild barley forms a two-rowed spike with a brittle rachis, whereas domestic barley has two- or six-rowed spikes with a tough rachis. As does domestic barley, "agriocrithon" forms a six-rowed spike; however the spike is brittle the same as wild barley, which makes the origin of agriocrithon obscure. Haplotype analysis of the Six-rowed spike 1 (vrs1) and the Non-brittle rachis 1 (btr1) and 2 (btr2) genes was conducted to infer the origin of agriocrithon barley. Some agriocrithon barley accessions (eu-agriocrithon) carried Btr1 and Btr2 haplotypes that are not found in any cultivars, implying that they are directly derived from wild barley through a mutation at the vrs1 locus...
February 22, 2018: Plant Journal: for Cell and Molecular Biology
Paolo Coghi, Ivan A Yaremenko, Parichat Prommana, Peter S Radulov, Mikhail A Syroeshkin, Yu Jun Wu, Jia Ying Gao, Flora M Gordillo-Martinez, Simon Mok, Vincent K W Wong, Chairat Uthaipibull, Alexander O Terent'ev
Twenty six peroxides belonging to bridged 1,2,4,5-tetraoxanes, bridged 1,2,4-trioxolanes (ozonides), and tricyclic monoperoxides were evaluated for the in vitro antimalarial activity against Plasmodium falciparum (3D7) and for their cytotoxic activities against immortalized human normal fibroblast (CCD19Lu), liver (LO2) and lung (BEAS-2B) cell lines as well as human liver (HepG2) and lung (A549) cancer cell lines. Synthetic ozonides were shown to have highest cytotoxicity on HepG2 (IC50 0.19-0.59 µM) and some of these compounds selectively targeted liver cancer (SI for compounds 13a and 14a is 20 and 28 respectively), which in some cases were higher than that of paclitaxel, artemisinin, artesunic acid...
February 22, 2018: ChemMedChem
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