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https://www.readbyqxmd.com/read/29220872/new-hydrazide-hydrazones-of-isonicotinic-acid-synthesis-lipophilicity-and-in-vitro-antimicrobial-screening
#1
Łukasz Popiołek, Anna Biernasiuk, Anna Berecka, Anna Gumieniczek, Anna Malm, Monika Wujec
This paper describes the synthesis, lipophilicity and in vitro antimicrobial assays of 15 new hydrazide-hydrazones of isonicotinic acid. New derivatives were obtained on the basis of the condensation reaction of isonicotinic acid hydrazide with different aromatic aldehydes. The chemical structure of synthesized compounds was confirmed by spectral methods. Experimental lipophilicity of new isonicotinic acid derivatives was determined using reversed-phase thin-layer chromatography. All synthesized compounds were subjected to in vitro antimicrobial assays against reference strains of Gram-positive bacteria, Gram-negative bacteria and fungi belonging to Candida spp...
December 8, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29220374/a-blaoxa-181-harbouring-multi-resistant-st147-klebsiella-pneumoniae-isolate-from-pakistan-that-represent-an-intermediate-stage-towards-pan-drug-resistance
#2
Fouzia Nahid, Rabaab Zahra, Linus Sandegren
Carbapenem resistant Klebsiella pneumoniae (CR-KP) infections are an ever-increasing global issue, especially in the Indian subcontinent. Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896 was isolated from a patient from Pakistan and was susceptible only to tigecycline and colistin. It harboured blaOXA-181 and was assigned to sequence type ST147...
2017: PloS One
https://www.readbyqxmd.com/read/29218503/differential-alterations-in-metabolism-and-proteolysis-related-proteins-in-human-parkinson-s-disease-substantia-nigra
#3
Edna Grünblatt, Josefine Ruder, Camelia Maria Monoranu, Peter Riederer, Moussa Bh Youdim, Silvia A Mandel
Parkinson's disease is the most common neurodegenerative disorder after Alzheimer's disease, with the majority of cases being sporadic or "idiopathic". The aetiology of the sporadic form is still unknown, but there is a broad consensus that Parkinson's disease involves multiple pathways. In previous human post-mortem studies investigating substantia nigra of parkinsonian subjects, gene expression alterations in various metabolic pathways including protein folding, trafficking, aggregation, ubiquitination and oxidative stress were found...
December 7, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29218442/silver-nanoparticle-conjugation-affects-antiacanthamoebic-activities-of-amphotericin-b-nystatin-and-fluconazole
#4
Ayaz Anwar, Ruqaiyyah Siddiqui, Muhammad Asim Hussain, Dania Ahmed, Muhammad Raza Shah, Naveed Ahmed Khan
Infectious diseases are the leading cause of morbidity and mortality, killing more than 15 million people worldwide. This is despite our advances in antimicrobial chemotherapy and supportive care. Nanoparticles offer a promising technology to enhance drug efficacy and formation of effective vehicles for drug delivery. Here, we conjugated amphotericin B, nystatin (macrocyclic polyenes), and fluconazole (azole) with silver nanoparticles. Silver-conjugated drugs were synthesized successfully and characterized by ultraviolet-visible spectrophotometry, Fourier transform infrared spectroscopy, and atomic force microscopy...
December 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29218433/s8orf2-protein-of-infectious-salmon-anaemia-virus-is-a-rna-silencing-suppressor-and-interacts-with-salmon-salar-mov10-ssmov10-of-the-host-rnai-machinery
#5
Vandana Thukral, Bhavna Varshney, Rimatulhana B Ramly, Sanket S Ponia, Sumona Karjee Mishra, Christel M Olsen, Akhil C Banerjea, Sunil K Mukherjee, Rana Zaidi, Espen Rimstad, Sunil K Lal
The infectious salmon anaemia virus (ISAV) is a piscine virus, a member of Orthomyxoviridae family. It encodes at least 10 proteins from eight negative-strand RNA segments. Since ISAV belongs to the same virus family as Influenza A virus, with similarities in protein functions, they may hence be characterised by analogy. Like NS1 protein of Influenza A virus, s8ORF2 of ISAV is implicated in interferon antagonism and RNA-binding functions. In this study, we investigated the role of s8ORF2 in RNAi suppression in a well-established Agrobacterium transient suppression assay in stably silenced transgenic Nicotiana xanthi...
December 7, 2017: Virus Genes
https://www.readbyqxmd.com/read/29218384/is-it-possible-to-give-a-single-definition-of-the-rectosigmoid-junction
#6
Damien Massalou, David Moszkowicz, Daniela Mariage, Patrick Baqué, Olivier Camuzard, Nicolas Bronsard
AIM: The rectosigmoid junction is the limit separating the sigmoid colon and rectum. This transition zone has different definitions. We want to highlight different landmarks of the rectosigmoid junction (RSJ), to help the clinicians to adopt a consensual definition. METHOD: We reviewed anatomical, endoscopic, physiological and surgical points of view concerning the rectosigmoid junction (RSJ). RESULTS: The rectosigmoid junction has a different definition depending on who is studying it...
December 7, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29218280/the-effect-of-lithospermum-officinale-silver-sulfadiazine-and-alpha-ointments-in-healing-of-burn-wound-injuries-in-rat
#7
Zahra Mohtasham Amiri, Nader Tanideh, Anahita Seddighi, Maral Mokhtari, Masood Amini, Alborz Shakouri Partovi, Amir Manafi, Seyedeh Sara Hashemi, Davood Mehrabani
BACKGROUND: Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat. METHODS: Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine (SSD), gel base and L. officinale extract, respectively. A hot plate was used for induction of a standard 3rd degree burn wound...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218008/improving-the-adherence-to-antiretroviral-therapy-a-difficult-but-essential-task-for-a-successful-hiv-treatment-clinical-points-of-view-and-practical-considerations
#8
REVIEW
Simona A Iacob, Diana G Iacob, Gheorghita Jugulete
HIV infection is responsible for one the most devastating human pandemics. The advent of antiretroviral therapy has changed the course of the pandemic and saved millions of lives. Complex therapeutic regimens have been introduced since 1996 and have contributed to the transformation of HIV infection into a treatable chronic diseases. New types of potent antiretrovirals and their combinations, including "once daily" treatment, have simplified the regimens and diminished side effects. Nevertheless the adherence to antiretroviral therapy remains unsatisfactory and varies between 27 and 80% across different population in various studies, compared with the required level of 95%...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29217858/effect-of-co-administration-of-different-doses-of-phenylephrine-with-oxytocin-on-the-prevention-of-oxytocin-induced-hypotension-in-caesarean-section-under-spinal-anaesthesia-a-randomised-comparative-study
#9
Ranjitha Gangadharaiah, Devika Rani Duggappa, Sudheesh Kannan, S B Lokesh, Karuna Harsoor, K M Sunanda, S S Nethra
Introduction: Co-administration of phenylephrine prevents oxytocin-induced hypotension during caesarean section under spinal anaesthesia (SA), but higher doses cause reflex bradycardia. This study compares the effects of co-administration of two different doses of phenylephrine on oxytocin-induced hypotension during caesarean section under SA. Methods: In this prospective, double-blind study, 90 parturients belonging to the American Society of Anesthesiologists' physical status 1 or 2, undergoing caesarean section under SA were randomised into Group A: oxytocin 3U and phenylephrine 50 μg, Group B: oxytocin 3U and phenylephrine 75 μg, Group C: oxytocin 3U and normal saline, administered intravenously over 5 min after baby extraction...
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29217829/genome-wide-genotyping-uncovers-genetic-profiles-and-history-of-the-russian-cattle-breeds
#10
Andrey Yurchenko, Nikolay Yudin, Ruslan Aitnazarov, Alexandra Plyusnina, Vladimir Brukhin, Vladimir Soloshenko, Bulat Lhasaranov, Ruslan Popov, Ivan A Paronyan, Kirill V Plemyashov, Denis M Larkin
One of the most economically important areas within the Russian agricultural sector is dairy and beef cattle farming contributing about $11 billion to the Russian economy annually. Trade connections, selection and breeding have resulted in the establishment of a number of breeds that are presumably adapted to local climatic conditions. Little however is known about the ancestry and history of Russian native cattle. To address this question, we genotyped 274 individuals from 18 breeds bred in Russia and compared them to 135 additional breeds from around the world that had been genotyped previously...
December 8, 2017: Heredity
https://www.readbyqxmd.com/read/29217769/structural-insights-into-ankyrin-repeat-mediated-recognition-of-the-kinesin-motor-protein-kif21a-by-kank1-a-scaffold-protein-in-focal-adhesion
#11
Wenfei Pan, Kang Sun, Kun Tang, Qingpin Xiao, Chenxue Ma, Cong Yu, Zhiyi Wei
Kidney ankyrin repeat-containing proteins (KANK1/2/3/4) belong to a family of scaffold proteins, playing critical roles in cytoskeleton organization, cell polarity and migration. Mutations in KANK proteins are implicated in cancers and genetic diseases, such as nephrotic syndrome. KANK proteins can bind various target proteins through different protein regions, including a highly conserved ankyrin repeat domain (ANKRD). However, the molecular basis for target recognition by the ANKRD remains elusive. In this study, we solved a high-resolution crystal structure of the ANKRD of KANK1 in complex with a short sequence of the motor protein kinesin family member 21A (KIF21A), revealing that the highly specific target-binding mode of the ANKRD involves combinatorial use of two interfaces...
December 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29217678/hrpu-2-a-homologue-of-mammalian-hnrnp-u-regulates-synaptic-transmission-by-controlling-the-expression-of-slo-2-potassium-channel-in-c-elegans
#12
Ping Liu, Sijie Jason Wang, Zhao-Wen Wang, Bojun Chen
Slo2 channels are large-conductance potassium channels abundantly expressed in the nervous system. However, it is unclear how their expression level in neurons is regulated. Here we report that HRPU-2, an RNA-binding protein homologous to mammalian hnRNP U, plays an important role in regulating the expression of SLO-2 (a homologue of mammalian Slo2) in C. elegans Loss-of-function (lf) mutants of hrpu-2 were isolated in a genetic screen for suppressors of a sluggish phenotype caused by a hyperactive SLO-2. In hrpu-2(lf) mutants, SLO-2-mediated delayed outward currents in neurons are greatly decreased, and neuromuscular synaptic transmission is enhanced...
December 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217674/pollen-pistil-interaction-in-pawpaw-asimina-triloba-the-northernmost-species-of-the-mainly-tropical-family-annonaceae
#13
Juan M Losada, Jose I Hormaza, Jorge Lora
PREMISE OF THE STUDY: The pawpaw, Asimina triloba, is an underutilized fruit crop native to North America that belongs to the mainly tropical, early-divergent family Annonaceae. Asimina is the only genus within the Annonaceae with species adapted to cold climates. A thorough analysis of its reproductive biology, specifically pollen-pistil interaction during the progamic phase, is essential to understand both its adaptation to cold climates and how to optimize its fertilization and fruit set...
December 7, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/29217592/loss-of-lofsep-transcription-factor-function-converts-spikelet-to-leaf-like-structures-in-rice
#14
Di Wu, Wanqi Liang, Wanwan Zhu, Mingjiao Chen, Cristina Ferrandiz, Rachel A Burton, Ludovico Dreni, Dabing Zhang
SEPALLATA (SEP)-like genes, which encode a subfamily of MADS-box transcription factors, are essential for specifying floral organ and meristem identity in angiosperms. Rice (Oryza sativa L.) has five SEP-like genes with partial redundancy and overlapping expression domains, yet their functions and evolutionary conservation are only partially known. Here, we describe the biological role of one of the SEP genes of rice, OsMADS5, in redundantly controlling spikelet morphogenesis. OsMADS5 belongs to the conserved LOFSEP subgroup along with OsMADS1 and OsMADS34...
December 7, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29217368/hla-g-a-haplotypes-in-amerindians-ecuador-hla-g%C3%A2-01-05n-world-distribution
#15
Antonio Arnaiz-Villena, Jose Palacio-Gruber, Mercedes Enriquez de Salamanca, Ignacio Juárez, Cristina Campos, Jorge Nuñez, Ester Muñiz, Jose Manuel Martin-Villa
HLA-G and HLA-A frequencies have been analysed in Amerindians from Ecuador. HLA-G allele frequencies are found to be closer to those of other Amerindians (Mayas from Guatemala and Uros from Peru) and closer to European ones than to Far East Asians groups, particularly, regarding to HLA-G∗ 01:04 allele. HLA-G/-A haplotypes have been calculated for the first time in Amerindians. It is remarkable that HLA-G∗01:05N "null" allele is found in a very low frequency (like in Amerindian Mayas and Uros) and is also found in haplotypes belonging to the HLA-A19 group of alleles (HLA-A∗30, -A∗31,-A∗33)...
December 4, 2017: Human Immunology
https://www.readbyqxmd.com/read/29217270/kafirin-from-sorghum-bicolor-inhibition-of-inflammation-in-thp-1-human-macrophages-is-associated-with-reduction-of-intracellular-reactive-oxygen-species
#16
Andrew C Sullivan, Philipus Pangloli, Vermont P Dia
Aberrant inflammation as a result of activation of the transmembrane protein Toll-like receptor 4 belonging to pattern recognition receptor and subsequent phosphorylation of signaling proteins facilitated by reactive oxygen species has been linked to a myriad of diseases. Sorghum is a drought-resistant cereal with health promoting properties associated with its biologically active substances such as kafirin. Kafirin is an alcoholsoluble protein and accounts for as much as 70% of the total proteins in sorghum...
December 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29217198/clinical-molecular-and-computational-analysis-in-two-cases-with-mitochondrial-encephalomyopathy-associated-with-suclg1-mutation-in-a-consanguineous-family
#17
Marwa Maalej, Amel Tej, Jihène Bouguila, Samia Tilouche, Senda Majdoub, Boudour Khabou, Mouna Tabbebi, Rahma Felhi, Marwa Ammar, Emna Mkaouar-Rebai, Leila Keskes, Lamia Boughamoura, Faiza Fakhfakh
Deficiency of the mitochondrial enzyme succinyl COA ligase (SUCL) is associated with encephalomyopathic mtDNA depletion syndrome and methylmalonic aciduria. This disorder is caused by mutations in both SUCL subunits genes: SUCLG1 (α subnit) and SUCLA2 (β subnit). We report here, two Tunisian patients belonging to a consanguineous family with mitochondrial encephalomyopathy, hearing loss, lactic acidosis, hypotonia, psychomotor retardation and methylmalonic aciduria. Mutational analysis of SUCLG1 gene showed, for the first time, the presence of c...
December 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29217146/the-association-between-adherence-to-a-mediterranean-style-diet-and-cognition-in-older-people-the-impact-of-medication
#18
Roy J Hardman, Denny Meyer, Greg Kennedy, Helen Macpherson, Andrew B Scholey, Andrew Pipingas
BACKGROUND: Recent reviews indicate that adherence to a Mediterranean diet may be associated with better cognitive functioning. In assessing these relationships in older individuals, previous studies have not taken into account medication usage that may support or compromise cognitive functioning. OBJECTIVE: To investigate the association between adherence to a Mediterranean style diet, cognition and medication usage in cognitively healthy older individuals. DESIGN: Data were assessed from individuals aged 60-90 years (mean = 77...
October 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29217118/checkpoints-in-tnf-induced-cell-death-implications-in-inflammation-and-cancer
#19
REVIEW
Alessandro Annibaldi, Pascal Meier
Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue homeostasis by regulating cytokine production, cell survival, and cell death. However, how life and death decisions are made in response to TNF is poorly understood. Many inflammatory pathologies are now recognized to be driven by aberrant TNF-induced cell death, which, in most circumstances, depends on the kinase Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Recent advances have identified ubiquitin (Ub)-mediated phosphorylation of RIPK1 as belonging to crucial checkpoints for cell fate in inflammation and infection...
December 4, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29216932/nanobodies-targeting-conserved-epitopes-on-the-major-outer-membrane-protein-of-campylobacter-as-potential-tools-for-control-of-campylobacter-colonization
#20
Charlotte Vanmarsenille, Inés Díaz Del Olmo, Jelle Elseviers, Gholamreza Hassanzadeh Ghassabeh, Kristof Moonens, Didier Vertommen, An Martel, Freddy Haesebrouck, Frank Pasmans, Jean-Pierre Hernalsteens, Henri De Greve
Campylobacter infections are among the most prevalent foodborne infections in humans, resulting in a massive disease burden worldwide. Broilers have been identified as the major source of campylobacteriosis and reducing Campylobacter loads in the broiler caeca has been proposed as an effective measure to decrease the number of infections in humans. Failure of current methods to control Campylobacter in broilers stresses the urgency to develop novel mitigation measures. We obtained six nanobodies with a broad specificity, that recognize strains belonging to the two most relevant species, Campylobacter jejuni and Campylobacter coli...
December 8, 2017: Veterinary Research
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