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J V C Guedes, J A Arnemann, L E Curioletti, L M Burtet, M L Ramírez-Paredes, D Noschang, F Irala de Oliveira, W T Tay
We provided the first scientific record of Melanagromyza sojae (Zehntner, 1900), through molecular characterization of partial mtDNA COI gene, that confirms the occurrence of this pest in Paraguay. Previously reported in Brazil, an outbreak of larvae of M. sojae known as the soybean stem fly (SSF) that belongs to the family Agromyzidae, was also noted in soybean fields from the Canindeyú, Alto Paraná and Itapúa Departments in Paraguay. This pest is highly polyphagous, attacking various host plant species from the family Fabaceae, such as soybean and other beans...
August 17, 2017: Genetics and Molecular Research: GMR
Olga Szaluś-Jordanow, Michał Czopowicz, Lucjan Witkowski, Marcin Mickiewicz, Tadeusz Frymus, Iwona Markowska-Daniel, Emilia Bagnicka, Jarosław Kaba
OBJECTIVES: To determine references intervals for echocardiographic measurements in adult dairy goats. ANIMALS: 125 clinically healthy, adult dairy goats aged 2-9 years, belonging to two breeds-Polish Fawn Improved (PFI, n = 64, weight range from 46 to 73, median of 58.5kg) and Polish White Improved (PWI, n = 61, weight range from 48 to 80 kg, median of 67.9kg), closely related to French Alpine and Saanen, respectively. METHODS: Non-invasive transthoracic echocardiography examination was performed in unsedated goats in a standing position...
2017: PloS One
Beomseok Suh, Dong Wook Shin, Hyung-Min Kwon, Jae Moon Yun, Hyung-Kook Yang, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho
Elevated neutrophil to lymphocyte ratio (NLR) has been reported as a marker for chronic inflammation, associated with poor prognosis in ischemic stroke patients, but there has been no study that investigated its association with ischemic stroke risk. This study was conducted to investigate elevated NLR as an independent risk factor for ischemic stroke incidence. Our retrospective cohort study included 24,708 generally healthy subjects aged 30-75 who received self-referred health screening at Seoul National University Hospital...
2017: PloS One
Radhey S Gupta, Richard M Epand
Diacylglycerol kinase (DGK) family of proteins, which phosphorylates diacylglycerol into phosphatidic acid, play important role in controlling diverse cellular processes in eukaryotic organisms. Most vertebrate species contain 10 different DGK isozymes, which are grouped into 5 different classes based on the presence or absence of specific functional domains. However, the relationships among different DGK isozymes or how they have evolved from a common ancestor is unclear. The catalytic domain constitutes the single largest sequence element within the DGK proteins that is commonly and uniquely shared by all family members, but there is limited understanding of the overall function of this domain...
2017: PloS One
Shingo Ito, Hideto Koso, Kazuhiro Sakamoto, Sumiko Watanabe
BACKGROUND: Glioblastoma is the most common form of malignant brain cancer and has a poor prognosis in adults. We identified Dhx15 as a candidate tumour suppressor gene in glioma by transposon-based mutagenesis. Dhx15 is an adenosine triphosphate (ATP)-dependent RNA helicase belonging to the DEAH-box (DHX) helicase family, but its role in cancer remains elusive. METHODS: DHX15 expression levels were examined in glioma cell lines. DHX15 functions were examined by gain- and loss-of-function analyses...
August 22, 2017: British Journal of Cancer
Wenjie Tan, Zhen Wu, Min Zhu, Jiajun Shen, Tiejun Zhu, Xinbing Zhao, Baibiao Huang, Xu-Tang Tao, Sheng-Qing Xia
A series of new magnesium bismuth Zintl phases, A14MgBi11 (A = Ca, Sr, Eu), have been synthesized, and their thermoelectric properties were systematically evaluated. These novel phases belong to the well-known Yb14MnSb11 family, whose structure adopts the tetragonal space group I41/acd (No. 142) with cell parameters of a = 17.0470(17)/17.854(2)/17.6660(7) Å and c = 22.665(5)/23.580(6)/23.2446(18) Å for Ca14MgBi11, Sr14MgBi11, and Eu14MgBi11, respectively. Without intentional optimization, these materials exhibit high potential as new thermoelectric candidates...
August 22, 2017: Inorganic Chemistry
Beibei Xiang, Xiaoxue Li, Yan Wang, Xiaoxuan Tian, Zhen Yang, Lin Ma, Xia Liu, Yong Wang
Swertia mussotii is an important medicinal plant found on the Qinghai Tibetan Plateau that has great economic and medicinal value. This plant has enjoyed a long history of use as a curative for hepatitis. The biological activity of secoiridoids, including gentiopicroside and swertiamarin, has been mainly tested for its anti-hepatitis effects. Here, we identify two candidate genes (SmIS1 and SmIS2) that are homologues of iridoid synthase and that are components of the secoiridoid pathway in S. mussotii. Using sequencing and phylogenetic analyses, we confirm that SmIS1 and SmIS2 contain six conserved short-chain dehydrogenases/reductase (SDR) motifs and thus belong to the P5βRs group...
August 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Susanne Roosing, Frans P M Cremers, Frans C C Riemslag, Marijke N Zonneveld-Vrieling, Herman E Talsma, Francoise J M Klessens-Godfroy, Anneke I den Hollander, L Ingeborgh van den Born
PURPOSE: To identify the gene defect and to study the clinical characteristics and natural course of disease in a family originally diagnosed with oligocone trichromacy (OT), a rare congenital cone dysfunction syndrome. METHODS: Extensive clinical and ophthalmologic assessment was performed on two siblings with OT and long-term follow up data were analyzed. Subsequently, whole exome sequencing (WES) and Sanger sequence analysis of CEP290 was performed in the two siblings...
August 22, 2017: Genes
Alessandra Gamberucci, Paola Marcolongo, Csilla E Németh, Nicoletta Zoppi, András Szarka, Nicola Chiarelli, Tamás Hegedűs, Marco Ritelli, Giulia Carini, Andy Willaert, Bert L Callewaert, Paul J Coucke, Angiolo Benedetti, Éva Margittai, Rosella Fulceri, Gábor Bánhegyi, Marina Colombi
GLUT10 belongs to a family of transporters that catalyze the uptake of sugars/polyols by facilitated diffusion. Loss-of-function mutations in the SLC2A10 gene encoding GLUT10 are responsible for arterial tortuosity syndrome (ATS). Since subcellular distribution of the transporter is dubious, we aimed to clarify the localization of GLUT10. In silico GLUT10 localization prediction suggested its presence in the endoplasmic reticulum (ER). Immunoblotting showed the presence of GLUT10 protein in the microsomal, but not in mitochondrial fractions of human fibroblasts and liver tissue...
August 22, 2017: International Journal of Molecular Sciences
Lucienne Juillerat-Jeanneret, Petra Tafelmeyer, Dela Golshayan
Fibroblast activation protein-α (FAP-α) belongs to the family of prolyl-specific serine proteases. FAP-α displays both exopeptidase and endopeptidase/gelatinase/collagenase activities. FAP-α protein and/or activity have been associated with fibrosis, inflammation and cancer, but the protein is undetectable in most normal tissues. FAP-α is selectively expressed at sites of tissue remodeling and repair and enhances tumor progression, suggesting that this protease may be a therapeutic target to treat human disorders associated with fibrotic dysregulation...
August 22, 2017: Expert Opinion on Therapeutic Targets
Yoshiaki Teraoka, Satoshi Kume, Yuxi Lin, Shogo Atsuji, Takashi Inui
Low water solubility of candidate drug compounds is a major problem in pharmaceutical research and development. We developed a novel drug delivery system (DDS) for poorly water-soluble drugs using lipocalin-type prostaglandin D synthase (L-PGDS), which belongs to the lipocalin superfamily and binds a large variety of hydrophobic molecules. In this study, we comprehensively evaluated the capability of L-PGDS to bind and solubilize various poorly-water soluble drugs using structure-based docking. Docking simulations of 2892 commercially available approved drugs indicated that L-PGDS shows higher binding affinities for various drugs compared with 2-hydroxypropyl-β-cyclodextrin...
August 22, 2017: Molecular Pharmaceutics
GiovanniMaria Piccini, Daniela Polino, Michele Parrinello
We have studied the cyclization reaction of deprotonated 4-chloro-1-butanethiol to tetrahydrothiophene by means of well-tempered metadynamics. To properly select the collective variables, we used the recently proposed variational approach to conformational dynamics within the framework of metadyanmics. This allowed us to select the appropriate linear combinations from a set of collective variables representing the slow degrees of freedom that best describe the slow modes of the reaction. We performed our calculations at three different temperatures, namely, 300, 350, and 400 K...
August 22, 2017: Journal of Physical Chemistry Letters
Sooyeon Park, Yong-Taek Jung, Ji-Min Park, Jung-Hoon Yoon
A Gram-stain-negative, non-flagellated, non-gliding, aerobic and rod-shaped or ovoid bacterium, designated strain KEM-10T, was isolated from water in an estuary environment in the Yellow Sea, South Korea, and subjected to a polyphasic taxonomic study. Strain KEM-10T grew optimally at 25 °C, at pH 7.0-8.0 and in the presence of 2.0 % (w/v) NaCl. A neighbour-joining phylogenetic tree based on 16S rRNA gene sequences revealed that strain KEM-10T belonged to the genus Algoriphagus, joining the type strain of Algoriphagus litorisediminis showing 97...
August 22, 2017: International Journal of Systematic and Evolutionary Microbiology
Suresh G, Sailaja B, Ashif A, Bharti P Dave, Sasikala Ch, Ramana Ch V
Three strains (JA826T, JA912T and JA913), which were yellowish brown colour, rod to oval shaped, Gram-stain-negative, motile, phototrophic bacteria with a vesicular architecture of intracytoplasmic membranes, were isolated from different pond samples. The DNA G+C content of the three strains was between 64.6 and 65.5 mol%. The highest 16S rRNA gene sequence similarity of all three strains was with the type strains of the genus Rhodobacter sensu stricto in the family Rhodobacteraceae. Strain JA826T had highest sequence similarity with Rhodobacter maris JA276T (98...
August 22, 2017: International Journal of Systematic and Evolutionary Microbiology
Yanhong Wu, Min Yu, Zenghu Zhang, Yanan Wang, Xiaoting Yang, Xiaolei Wang, Qiaomeng Ren, Zhongcheng Sun, Xiaochong Shi, Xiao-Hua Zhang
A Gram-staining-negative, yellow-colony-forming, rod-shaped, non-flagellated and facultatively aerobic strain, designed HRA130-1T, was isolated from a deep-sea polymetallic nodule from the Pacific Clarion-Clipperton Fracture Zone (CCFZ). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain HRA130-1T belonged to the genus Polaribacter (96.3-93.2 % 16S rRNA gene sequence similarity), and exhibited 94 % 16S rRNA gene sequence similarity to Polaribacter filamentus KCTC 23135T (type species) and the highest sequence similarity to Polaribacter huanghezhanensis KCTC 32516T (96...
August 22, 2017: International Journal of Systematic and Evolutionary Microbiology
Gabrielle B McCallum, Peter S Morris, Ngiare Brown, Anne B Chang
BACKGROUND: People with asthma who come from minority groups often have poorer asthma outcomes, including more acute asthma-related doctor visits for flare-ups. Various programmes used to educate and empower people with asthma have previously been shown to improve certain asthma outcomes (e.g. adherence outcomes, asthma knowledge scores in children and parents, and cost-effectiveness). Models of care for chronic diseases in minority groups usually include a focus of the cultural context of the individual, and not just the symptoms of the disease...
August 22, 2017: Cochrane Database of Systematic Reviews
Beatriz López-Corcuera, Cristina Benito-Muñoz, Carmen Aragón
Glycine, besides exerting essential metabolic functions, is an important inhibitory neurotransmitter in caudal areas of the central nervous system and also a positive neuromodulator at excitatory glutamate-mediated synapses. Glial cells provide metabolic support to neurons and modulate synaptic activity. Six transporters belonging to three solute carrier families (SLC6, SLC38, and SLC7) are capable of transporting glycine across the glial plasma membrane. The unique glial glycine-selective transporter GlyT1 (SLC6) is the main regulator of synaptic glycine concentrations, assisted by the neuronal GlyT2...
2017: Advances in Neurobiology
Negar Bizhani, Abdol Motalleb Sharifi, Mohmmad Bagher Rokni, Jean Dupouy Camet, Mostafa Rezaeian, Mohammad Fallah Kiapi, Niloofar Paknezhad, Faezeh Najafi, Gholamreza Mowlavi
BACKGROUND: Along with the newly emergence of paleoparasitology research in Iran, findings of parasites from Northern part of the county have not been reported so far. In this study tracking for the lancet liver fluke dates back 250 BC is addressed. METHODS: Samples were taken from grave crypts of the soil layers attached to the pelvic bones from above-mentioned site in 2015. The laboratory examinations were conducted in the Dept. of Medial Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran...
June 2017: Iranian Journal of Public Health
Padmanabhan Guruprasad, Kamal Kishore, Sandeep Mahajan, Sandeep Aggarwal
AIM: Renal transplantation is the treatment of choice for end-stage renal disease patients. Renal transplant recipients, however, have to be on lifelong therapy with immunosuppressants, which are associated with a number of adverse events (AEs). The safety profile of these immunosuppressants is not clear with respect to the Indian population. This study was conducted to find the frequency and pattern of all AEs experienced by Indian renal transplant recipients during the initial 3 months posttransplantation...
July 2017: Perspectives in Clinical Research
Guillaume Billet, Lionel Hautier, Benoit de Thoisy, Frédéric Delsuc
BACKGROUND: With their Pan-American distribution, long-nosed armadillos (genus Dasypus) constitute an understudied model for Neotropical biogeography. This genus currently comprises seven recognized species, the nine-banded armadillo (D. novemcinctus) having the widest distribution ranging from Northern Argentina to the South-Eastern US. With their broad diversity of habitats, nine-banded armadillos provide a useful model to explore the effects of climatic and biogeographic events on morphological diversity at a continental scale...
2017: PeerJ
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