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https://www.readbyqxmd.com/read/27885882/state-of-the-art-of-ultrasound-in-the-assessment-of-psoriasis-and-psoriatic-arthritis
#1
Marwin Gutierrez, Gurjit S Kaeley, Chiara Bertolazzi, Carlos Pineda
Ultrasound (US) is a rapidly evolving technique that is gaining increasing success in the assessment of psoriatic arthritis (PsA). Recently, new research avenues have been opened, and these are focused on the potential of US for the assessment of extra musculoskeletal areas such as skin and nails. This permits work on the concept of 'holistic US assessment of PsA'. Areas covered: Here, we analyze the potential role of US in the global assessment of PsA. Additionally, we provide the current evidence supporting its application in routine clinical practice...
December 2, 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27882586/efficacy-and-safety-of-dose-escalation-of-infliximab-therapy-in-japanese-patients-with-psoriasis-results-of-the-spread-study
#2
Hideshi Torii, Masayuki Nakano, Toshiro Yano, Kazuoki Kondo, Hidemi Nakagawa
Although infliximab is approved for psoriasis, its efficacy is reduced over time in some patients. The aim of this phase III trial is to evaluate efficacy and safety of infliximab dose escalation in Japanese psoriasis patients with loss of efficacy to standard-dose therapy. Patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis or psoriatic erythroderma who showed loss of efficacy to standard-dose therapy received infliximab dose escalation (10 mg/kg every 8 weeks) from weeks 0 to 32. Loss of efficacy was defined as not maintaining 50% reduction in the Psoriasis Area and Severity Index (PASI 50) after achieving PASI 75...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27873356/nail-psoriasis-a-systematic-evaluation-in-313-children-with-psoriasis
#3
Diane Pourchot, Christine Bodemer, Alice Phan, Anne-Claire Bursztejn, Smaïl Hadj-Rabia, Franck Boralevi, Juliette Miquel, Thomas Hubiche, Eve Puzenat, Anne-Laure Souillet, Ingrid Kupfer, Maryam Piram, Alain Beauchet, Emmanuel Mahé
BACKGROUND/OBJECTIVES: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. METHODS: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27860304/nail-involvement-can-predict-enthesopathy-in-patients-with-psoriasis
#4
Maria Castellanos-González, Beatriz Esther Joven, Julio Sánchez, Eva María Andrés-Esteban, Francisco Vanaclocha-Sebastián, Pablo Ortiz Romero, Raquel Rivera Díaz
BACKGROUND: Although subclinical enthesopathy is a well-established diagnostic criterion for psoriatic arthritis (PsA), it is frequently overlooked, as many patients are asymptomatic. The possibility of finding a clinical clue predicting enthesopathy would help clinicians establish an early diagnosis of PsA. MATERIAL AND METHODS: A prospective single-center study of a total of 90 patients with psoriasis was conducted to assess the presence of entheseal abnormalities as detected by ultrasound, and to determine any correlation with nail involvement...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27836567/management-of-psoriatic-arthritis-early-diagnosis-monitoring-of-disease-severity-and-cutting-edge-therapies
#5
REVIEW
Siba P Raychaudhuri, Reason Wilken, Andrea C Sukhov, Smriti K Raychaudhuri, Emanual Maverakis
Psoriatic arthritis (PsA) is a heterogeneous disease that can involve a variety of distinct anatomical sites including a patient's peripheral and axial joints, entheses, skin and nails. Appropriate management of PsA requires early diagnosis, monitoring of disease activity, and utilization of cutting edge therapies. To accomplish the former there are a variety of PsA-specific tools available to screen, diagnose, and assess patients. This review will outline the recently developed PsA screening tools, including the Toronto Psoriatic Arthritis Screening Questionnaire (TOPAS), the Psoriasis Epidemiology Screening Tool (PEST), the Psoriatic Arthritis Screening and Evaluation (PASE), and the Psoriasis and Arthritis Screening Questionnaire (PASQ)...
November 8, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27750274/predictors-of-response-to-tnf-blockers-in-patients-with-polyarticular-psoriatic-arthritis
#6
Pedro David Carvalho, Cátia Duarte, Elsa Vieira-Sousa, Luís Cunha-Miranda, Pedro Avila-Ribeiro, Helena Santos, Miguel Bernardes, Maria José Santos, Marcos Cerqueira, Margarida Mateus, Patrícia Nero, Ana Águeda, José António Pereira da Silva, Pedro Machado
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease with a broad clinical spectrum. PsA can affect the axial skeleton, peripheral joints, entheses, synovial sheaths of tendons, skin, nails and extra-articular organs. Tumour necrosis factor alpha blockers (TNF blockers) were a breakthrough development in the treatment of PsA. Identifying predictors of response to biological therapies in patients with PsA is of utmost importance, especially in view of the costs and potential side effects of these agents...
August 17, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27726163/efficacy-and-safety-of-ixekizumab-treatment-for-japanese-patients-with-moderate-to-severe-plaque-psoriasis-erythrodermic-psoriasis-and-generalized-pustular-psoriasis-results-from-a-52-week-open-label-phase-3-study-uncover-j
#7
Hidehisa Saeki, Hidemi Nakagawa, Ko Nakajo, Taeko Ishii, Yoji Morisaki, Takehiro Aoki, Gregory S Cameron, Olawale O Osuntokun
Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Ixekizumab was administrated s.c. at baseline (week 0, 160 mg), from weeks 2 to 12 (80 mg every 2 weeks), and from weeks 16 to 52 (80 mg every 4 weeks)...
October 11, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27706115/childhood-psoriasis-a-survey-among-pediatricians-in-italy
#8
Porfirio Toscano, Paolo Chiodini, Orsola Ametrano, Elvira Moscarella
BACKGROUND: Psoriasis is one of the most common inflammatory skin diseases. There seem to be an increasing interest in childhood psoriasis in recent years. METHODS: We conducted a survey among pediatricians in Italy. 50 pediatricians from different areas in Italy (north, center and south) were invited to participate, 37 were responding and active in data collection. Doctors were asked to review their databases and to fill a form providing a series of information about all patients diagnosed with psoriasis attending their ambulatory...
October 5, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27683154/speckled-variance-optical-coherence-tomography-for-the-assessment-of-nail-involvement-in-acrodermatitis-continua-of-hallopeau-a-case-study
#9
Andrea Conti, Silvana Ciardo, Victor Desmond Mandel, Laura Bigi, Giovanni Pellacani
Noninvasive techniques for nail imaging would be useful for confirming diagnosis and monitoring treatment response at the microscopic level in patients with nail psoriasis. However, the use of ultrasound and high-resolution magnetic resonance imaging in nail evaluation is limited. Optical coherence tomography (OCT) produces high-resolution images of transversal tissue sections and represents an optimal approach to the study of the nail. This study used a multibeam OCT instrument to produce speckled variance OCT (SV-OCT) blood-flow images, which were used to measure the degree of change over successive scans...
September 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27633825/incidence-of-malignancies-in-a-cohort-of-psoriatic-arthritis-patients-taking-traditional-disease-modifying-antirheumatic-drug-and-tumor-necrosis-factor-inhibitor-therapy-an-observational-study
#10
Luisa Costa, Francesco Caso, Antonio Del Puente, Matteo Nicola Dario Di Minno, Rosario Peluso, Raffaele Scarpa
OBJECTIVE: Psoriatic arthritis (PsA) is an inflammatory arthropathy, associated with skin and/or nail psoriasis. As suggested in 2012 by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), studies devoted to assess cancer in the PsA population are still limited and need to be increased. Therefore, the aim of this study was to determine the incidence of malignancies in patients with PsA who are taking conventional and biologic therapies. METHODS: A cohort of patients with PsA was followed prospectively...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27632414/expression-of-inflammatory-cytokines-in-psoriatic-nails
#11
I Saulite, M Pilmane, E Guenova, J Kisis
No abstract text is available yet for this article.
September 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27622407/high-frequency-sonography-in-the-evaluation-of-nail-psoriasis
#12
Mihaela Elena Marina, Carolina Solomon, Sorana-Daniela Bolboaca, Corina Bocsa, Carmen Mihaela Mihu, Alexandru Dumitru Tătaru
AIM: To evaluate the morphostructural aspects and nail vascularity in the nail unit of patients with psoriasis, and to evaluate whether there are differences among psoriatic patients with and without nail involvement. MATERIAL AND METHODS: Nail plates and nail bed changes, nail fold vessel resistance index (NVRI), power and color Doppler blood flow appearances were investigated in 23 patients with moderate-to-severe psoriasis, with and without nail involvement, and compared to those of 11 healthy participants...
September 2016: Medical Ultrasonography
https://www.readbyqxmd.com/read/27599783/identification-of-nail-features-associated-with-psoriasis-severity
#13
Jee Woong Choi, Bo Ri Kim, Eunmi Seo, Sang Woong Youn
There are no detailed studies of the prevalence of nail psoriasis and clinical characteristics of psoriatic nail involvement, including nail features associated with disease severity. Therefore, we designed a study to investigate the prevalence and characteristics of psoriatic nail involvement in patients with psoriasis and determine the relationship between psoriatic nail features and severity of nail psoriasis and cutaneous psoriasis. The Nail Psoriasis Severity Index (NAPSI) was used for evaluation of the severity of nail lesions...
September 7, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27537996/ixekizumab-is-effective-in-subjects-with-moderate-to-severe-plaque-psoriasis-with-significant-nail-involvement-results-from-uncover-3
#14
Ellen B Dennehy, Lu Zhang, David Amato, Orin Goldblum, Phoebe Rich
BACKGROUND: Ixekizumab, a monoclonal antibody that selectively targets interleukin-17A, has been established as safe and effective in 3 Phase 3 trials for the treatment of moderate to severe plaque psoriasis. The lifetime incidence of psoriatic nail disease is 80%-90% of patients, and approximately 50% of patients with psoriasis have nail involvement.<BR /> MATERIALS AND METHODS: The design of UNCOVER-3, a Phase 3, multicenter, double-blind, placebo- and active-controlled trial that evaluated the efficacy and safety of ixekizumab for moderate to severe psoriasis, has been published previously...
August 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27508394/prevalence-of-psoriatic-arthritis-and-its-correlates-among-patients-with-psoriasis-in-greece-results-from-a-large-retrospective-study
#15
E Papadavid, P Katsimbri, I Kapniari, D Koumaki, A Karamparpa, M Dalamaga, K Tzannis, D Βoumpas, D Rigopoulos
OBJECTIVES: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital. METHODS: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013. RESULTS: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Their median age was 51.41 with median psoriasis presenting age of 34.52 years...
August 10, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27498667/an-innovative-promising-topical-treatment-for-psoriasis-a-romanian-clinical-study
#16
S Gianfaldoni, J Hercogovấ, M Fioranelli, A A Chokoeva, G Tchernev, U Wollina, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. Even if today many therapeutic options are available for psoriasis treatment, none of them provide excellent clinical results without the risk of side effects...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27498654/nail-psoriasis-in-an-adult-successfully-treated-with-a-series-of-herbal-skin-care-products-family-%C3%A2-a-case-report
#17
M Tirant, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, U Wollina, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a common chronic inflammatory dermatosis that causes significant distress and morbidity. Approximately 50% of patients with cutaneous psoriasis and 90% of patients with psoriatic arthritis demonstrate nail involvement of their psoriasis. Left untreated, nail psoriasis may progress to debilitating nail disease that leads to not only impairment of function but also on quality of life. We report the case of a 50-year-old male patient with recalcitrant nail dystrophies on the fingers since the age of 40, who responded successfully to Dr...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27498653/a-clinical-examination-of-the-efficacy-of-preparation-of-dr-michaels%C3%A2-also-branded-as-soratinex%C3%A2-products-in-the-treatment-of-psoriasis
#18
J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, U Wollina, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. The aim of the study was to investigate the efficacy of Dr Michaels® (Soratinex®) product line in the treatment of psoriatic patients with different age and disease severity...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27498651/a-multi-centred-open-trial-of-%C3%A2-dr-michaels%C3%A2-%C3%A2-also-branded-as-soratinex%C3%A2-topical-product-family-in-psoriasis
#19
U Wollina, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a chronic, recurring skin disease affecting 2-4% of the population. Genetic predisposition and precipitating factors play a role in its etiology. The disease can occur in any age or gender group. The most frequently affected areas of the body include scalp, extensor surfaces of the extremities, skin folds and nails. While a number of therapies exist for the treatment of psoriasis with a total resolution of the skin, achieving remission in a high percentage of sufferers, a treatment that results in the maintenance of remission and is free of side effects is still a desirable goal...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27487860/psoriatic-arthritis-lessons-from-imaging-studies-and-implications-for-therapy
#20
Ashish J Mathew, Laura C Coates, Debashish Danda, Philip G Conaghan
INTRODUCTION: Modern imaging may aid in the diagnosis, prognosis and monitoring of therapeutic response in psoriatic arthritis (PsA). Detection of osteitis and technical advances like whole body magnetic resonance imaging (MRI) exemplify the value of this technology. AREAS COVERED: Ultrasound (US) provides a clinic-based tool for evaluating both joint pathologies and extra-articular structures (especially enthesitis) including skin and nail disease. Recent studies have demonstrated subclinical disease in psoriasis without arthritis, as well as in PsA, with implications for diagnosis and treatment classification...
August 4, 2016: Expert Review of Clinical Immunology
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