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https://www.readbyqxmd.com/read/29067616/a-clinical-review-of-phototherapy-for-psoriasis
#1
REVIEW
Ping Zhang, Mei X Wu
Psoriasis is an autoimmune inflammatory skin disease. In the past several decades, phototherapy has been widely used to treat stable psoriatic lesions, including trunk, scalp, arms and legs, and partial nail psoriasis. A variety of light/lasers with different mechanisms of action have been developed for psoriasis including ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), and so on. Because light/laser each has specific therapeutic and adverse effects, it is important to adequately choose the sources and parameters in management of psoriasis with different pathogenic sites, severities, and duration of the disorder...
October 24, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29058948/pace-study-real-life-pasi-100-response-with-biological-agents-in-moderate-severe-psoriasis
#2
Carlo Giovanni Carrera, Paolo Dapavo, Piergiorgio Malagoli, Luigi Naldi, Luisa Arancio, Francesca Gaiani, Colin Gerard Egan, Marco Di Mercurio, Angelo Cattaneo
BACKGROUND: Few studies have compared the use of different biologics in a real-life setting in plaque psoriasis patients. OBJECTIVE: To compare the efficacy of biologics in psoriasis/psoriatic arthritis patients. METHODS: Patients treated with adalimumab, etanercept and ustekinumab for at least 16 weeks were included. Achievement of PASI90/100 response and time taken to achieve PASI90/100 response were measured. Logistic regression was used to evaluate the effect of psoriasis localization on achievement of PASI100 response...
October 23, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28919705/new-insight-into-the-pathogenesis-of-nail-psoriasis-and-overview-of-treatment-strategies
#3
REVIEW
Alessandra Ventura, Mauro Mazzeo, Roberta Gaziano, Marco Galluzzo, Luca Bianchi, Elena Campione
Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Differential diagnosis between an onychomycosis and a psoriatic nail could be challenging; nevertheless, coexistence of onychomycosis and nail psoriasis also occurs and both are common disorders in the general population...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28816983/characteristics-of-turkish-patients-with-elderly-onset-psoriatic-arthritis-a-retrospective-cohort-study
#4
Senol Kobak, Fidan Yildiz, Ahmet Karaarslan, Huseyin Semiz, Mehmet Orman
Psoriatic arthritis (PsA) is a chronic inflamatory disease characterized with axial and peripheral joints involvement. It rarely affects patients older than 65 years old.The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset psoriatic arthritis (EOPsA) and young-onset (YOPsA) patients.A total of 180 patients diagnosed with PsA according to CASPAR criteria and followed-up in single center were included in this study. The patients with initial symptoms started after age 65 were accepted as EOPsA...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28769136/nail-involvement-in-psoriatic-arthritis
#5
REVIEW
Piotr Sobolewski, Irena Walecka, Klaudia Dopytalska
Nail psoriasis is considered a significant psychological and social problem causing functional impairment in affected patients. Nail changes hamper their daily and occupational activities and contribute to a worse quality of life. Almost 50% of patients with psoriasis vulgaris and up to 80% of patients with psoriatic arthritis are afflicted with nail lesions. The important correlation between psoriatic arthritis and nail changes is well established - the presence of the latter is a strong predictor of the development of arthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28761838/topical-therapies-in-psoriasis
#6
REVIEW
R Torsekar, Manjyot M Gautam
Topical therapy as monotherapy is useful in psoriasis patients with mild disease. Topical agents are also used as adjuvant for moderate-to-severe disease who are being concurrently treated with either ultraviolet light or systemic medications. Emollients are useful adjuncts to the treatment of psoriasis. Use of older topical agents such as anthralin and coal tar has declined over the years. However, they are cheaper and can still be used for the treatment of difficult psoriasis refractory to conventional treatment...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761301/a-case-of-nail-psoriasis-improved-by-treatment-with-golimumab-in-a-psoriatic-arthritis-patient
#7
So Young Jung
No abstract text is available yet for this article.
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28752373/skin-manifestations-of-rheumatoid-arthritis-juvenile-idiopathic-arthritis-and-spondyloarthritides
#8
REVIEW
Carolyn Jean Chua-Aguilera, Burkhard Möller, Nikhil Yawalkar
Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28725251/custom-made-micro-applicators-for-high-dose-rate-brachytherapy-treatment-of-chronic-psoriasis
#9
Ivan M Buzurovic, Desmond A O'Farrell, Mandar S Bhagwat, Jorgen L Hansen, Thomas C Harris, Scott Friesen, Robert A Cormack, Phillip M Devlin
PURPOSE: In this study, we present the treatment of the psoriatic nail beds of patients refractory to standard therapies using high-dose-rate (HDR) brachytherapy. The custom-made micro applicators (CMMA) were designed and constructed for radiation dose delivery to small curvy targets with complicated topology. The role of the HDR brachytherapy treatment was to stimulate the T cells for an increased immune response. MATERIAL AND METHODS: The patient diagnosed with psoriatic nail beds refractory to standard therapies received monthly subunguinal injections that caused significant pain and discomfort in both hands...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28691207/hyperuricemia-is-an-independent-risk-factor-for-psoriatic-arthritis-in-psoriatic-patients
#10
Noriko Tsuruta, Shinichi Imafuku, Yutaka Narisawa
Psoriatic arthritis (PsA) is a spondyloarthritic condition mainly seen in patients with psoriasis. Psoriatic patients with plaques on the scalp, gluteal fold or nail lesions are known to develop PsA more frequently, but other markers for PsA have not yet been identified. To determine which psoriatic patients are at greatest risk of developing PsA, psoriasis vulgaris (PsV) patients who visited the Department of Dermatology, Fukuoka University Hospital in 2015 were enrolled. Patients with and without PsA were statistically compared with respect to age, sex, age at onset, body mass index (BMI), smoking and drinking habits, familial history of psoriasis and comorbidities...
July 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28681115/-psoriatic-arthritis-drugs-of-the-near-future
#11
REVIEW
D Redelstein, M Fleck
The treatment of psoriatic arthritis (PsA) necessitates different and highly effective treatment strategies due to the diverse clinical manifestations. Drugs that exhibit efficacy for most of the musculoskeletal (e.g. arthritis, dactylitis, enthesitis and spondyloarthritis) and extra-articular manifestations (e.g. skin and nail lesions) are therefore of special interest. This review presents a selection of drugs for the treatment of PsA, which might be available within the (near) future. Based on an improved understanding of the pathopysiology of psoriasis as well as PsA, novel therapeutic approaches are under development...
July 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28666612/nail-findings-in-patients-with-psoriatic-arthritis-a-cross-sectional-study-with-special-reference-to-transverse-grooves
#12
COMPARATIVE STUDY
Yukari Zenke, Yuri Ohara, Daiki Kobayashi, Satoru Arai, Mitsumasa Kishimoto, Masato Okada, Hikaru Eto
BACKGROUND: Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations. OBJECTIVE: This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without arthritis. METHODS: We performed a retrospective analysis of 118 patients with PsA and 974 patients with psoriasis without arthritis who visited St. Luke's International Hospital (Tokyo, Japan) between July 2003 and February 2015...
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28664284/-differential-diagnostic-spectrum-of-psoriasis-vs-psoriatic-arthritis-in-skin-and-joints
#13
REVIEW
S Gerdes, U Mrowietz, U Wagner
Psoriasis and psoriatic arthritis are common disease entities in the daily routine of dermatologists and rheumatologists. The clinical management of the diseases profits tremendously from interdisciplinary contacts and shared decision-making processes. For dermatologists, recognition of early clinical symptoms of inflammatory arthropathies is pivotal. Rheumatologists, on the other hand, are required to make an early assessment of skin and nail changes in patients, since they are important parameters in the clinical classification of inflammatory joint diseases, in particular for the diagnosis of psoriatic arthritis...
June 29, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28656915/clinical-and-serological-characteristics-of-nail-psoriasis-in-indian-patients-a-cross-sectional-study
#14
Deepashree Daulatabad, Chander Grover, Bineeta Kashyap, Amit Kumar Dhawan, Archana Singal, Iqbal R Kaur
BACKGROUND: Nail involvement in psoriasis is common with a lifetime incidence of 80-90%. It may reflect severity of cutaneous involvement and predict joint disease. Yet it remains, poorly studied and evaluated especially in Indian psoriatic patients. AIM: The present study was undertaken to evaluate clinical and serological profile of nail involvement in psoriasis and to assess quality of life impairment associated with nail involvement in Indian patients. METHODS: Consecutive patients with nail psoriasis were assessed for severity of cutaneous disease (psoriasis area severity index score) and nail disease (nail psoriasis severity index score)...
June 28, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28648658/ultrasound-entheseal-abnormalities-at-the-distal-interphalangeal-joints-and-clinical-nail-involvement-in-patients-with-psoriasis-and-psoriatic-arthritis-supporting-the-nail-enthesitis-theory
#15
Maria Laura Acosta-Felquer, Santiago Ruta, Javier Rosa, Josefina Marin, Leandro Ferreyra-Garrot, Maria Laura Galimberti, Ricardo Galimberti, Ricardo Garcia-Monaco, Enrique R Soriano
OBJECTIVE: It has been shown that nail involvement in psoriasis is associated with systemic enthesopathy. Our objective was to evaluate the association of nail involvement and enthesopathy at distal interphalangeal joint (DIP) level in psoriasis (PsO) and psoriatic arthritis (PsA) patients. METHODS: Consecutive patients (54 PsO and 56 PsA) seen at the outpatients clinic in this cross-sectional study were included. All patients underwent both clinical and ultrasound (US) assessment on the same day...
May 11, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28628470/vascularity-of-nail-bed-by-ultrasound-to-discriminate-psoriasis-psoriatic-arthritis-and-healthy-controls
#16
Sibel Zehra Aydin, Concepción Castillo-Gallego, Zoe R Ash, Helena Marzo-Ortega, Richard Wakefield, Dennis McGonagle
No abstract text is available yet for this article.
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28625638/development-of-psoriatic-arthritis-during-nivolumab-therapy-for-metastatic-non-small-cell-lung-cancer-clinical-outcome-analysis-and-review-of-the-literature
#17
Juan Ruiz-Bañobre, Eva Pérez-Pampín, Jorge García-González, Antonio Gómez-Caamaño, Francisco Javier Barón-Duarte, Rafael López-López, Francisca Vázquez-Rivera
Lung cancer is the leading cause of cancer-related death worldwide. The most common type, non-small cell lung cancer (NSCLC), is further divided into two main types, squamous cell and non-squamous cell (which includes adenocarcinoma). Nivolumab, a fully human IgG4 programmed death-1 immune checkpoint inhibitor antibody, has shown not only an overall survival advantage when compared to docetaxel, but also a relatively good side-effect profile among patients with previously treated advanced squamous and non-squamous NSCLC...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28612459/detection-of-dermatological-abnormalities-in-the-rheumatology-clinic-using-a-standardized-screening-exam
#18
Newton Wai Kwan Wong, Tanveer Ezad Towheed, Wilma Hopman, Mark Gajda Kirchhof
AIM: To develop a standardized practical screening tool for rheumatologists to assess for underlying dermatological manifestations of rheumatic conditions. METHODS: A relevant screening tool was developed by consensus between dermatology and rheumatology authors. Patients visiting the general rheumatology clinic for routine care were systematically assessed based on the standardized screening tool. RESULTS: One hundred patients were recruited with 76 being female...
June 14, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28611632/infliximab-induced-aseptic-meningitis-during-the-treatment-of-psoriatic-arthritis
#19
Yuki Matsuura-Otsuki, Takaaki Hanafusa, Hiroo Yokozeki, Kyoko Watanabe
A 42-year-old Japanese man presented with persistent headache during treatment for psoriatic arthritis (PsA) with infliximab. Treatment with infliximab was initiated 3 years before and the psoriatic skin lesions with arthritis were well controlled. However, after 21 doses of infliximab, the skin lesions and joint pain exacerbated and became intractable. Ten days after the dosage of infliximab was increased, the patient experienced headache and nausea with high fever. He had scaly, well-circumscribed erythemas on his trunk, extremities, and deformed nails...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28608530/psoriasis-in-latin-america-and-the-caribbean-a-systematic-review
#20
REVIEW
A Hernández-Vásquez, L Molinari, N Larrea, A Ciapponi
Psoriasis is a chronic inflammatory disease that generally affects the skin, nails and joints. The burden of psoriatic disease in Latin America and the Caribbean (LAC) remains largely unknown. To estimate the burden of psoriasis in LAC. We conducted a systematic review following the MOOSE and PRISMA statements. We searched published studies in MEDLINE, EMBASE, LILACS and CENTRAL from 1st January 2000 to 5th August 2015. We included studies that reported incidence, prevalence, health resource use and health expenditures, treatment patterns, comparative effectiveness of different drugs, patients reported outcomes, adherence to treatment and patient preferences in LAC...
June 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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