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Psoriatic nail

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https://www.readbyqxmd.com/read/29757042/comparison-of-napsi-and-n-nail-for-evaluation-of-fingernail-psoriasis-in-patients-with-moderate-to-severe-plaque-psoriasis-treated-using-ustekinumab
#1
Bo Ri Kim, Seungkeol Yang, Chong Won Choi, Sang Woong Youn
OBJECTIVE: We sought to determine which psoriatic nail features more effectively respond to ustekinumab treatment and evaluate which between the Nail Psoriasis Severity Index (NAPSI) and the Nijmegen-Nail psoriasis Activity Index tooL (N-NAIL) better reflects the clinical improvement of nail psoriasis. METHODS: Thirty patients with moderate-to-severe plaque psoriasis were prospectively enrolled; the patients were treated with ustekinumab for 52 weeks. A single investigator evaluated the condition using the NAPSI and the N-NAIL with serial fingernail photographs...
May 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29730685/the-microvascular-and-morphostructural-changes-of-nails-in-psoriatic-patients-with-nail-disease-a-link-between-ultrasound-and-videocapillaroscopy-findings-in-the-nailfold
#2
Sibel Bakirci Ureyen, Rabia Oztas Kara, Zeynep Erturk, Mahizer Yaldiz
OBJECTIVE: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs). MATERIAL AND METHODS: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29730684/ultrasonography-of-the-nail-unit-reveals-quantitative-and-qualitative-alterations-in-patients-with-psoriasis-and-psoriatic-arthritis
#3
Luca Idolazzi, Paolo Gisondi, Angelo Fassio, Ombretta Viapiana, Alessandro Giollo, Maurizio Rossini, Giampiero Girolomoni, Davide Gatti
AIMS: The nail unit is a matter of interest both for dermatologist and rheumatologist. The nail is considered one of the possible targets of assessment, especially when ultrasonography is performed. The aim of the study is to highlight peculiar features and alterations of the nail unit in patients affected by psoriasis and psoriatic arthritis versus healthy controls using ultrasonography. MATERIALS AND METHODS: The study sample included 82 patients affected by psoriasis and/or psoriatic arthritis and 50 healthy controls...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29706002/-subclinical-enthesopathy-of-at-least-one-extensor-digitorum-tendon-is-highly-prevalent-and-associated-with-clinical-and-ultrasound-alterations-of-the-adjacent-finger-nails-in-patients-with-psoriatic-disease
#4
P Moya Alvarado, E Roé Crespo, F Z Muñoz-Garza, A López-Ferrer, A Laiz Alonso, E Vilarrassa Rull, J Casademont, L Puig Sanz
BACKGROUND: Nail psoriasis disease is associated with an increased probability of psoriatic arthritis and its clinical signs may have different correlates with the pathogenesis of adjacent bone destruction and have different prognostic value. Recent publications about psoriasis and nail psoriatic disease describe different ultrasonographic findings but the relationship between these ungueal alterations measured by ultrasonography and the presence of enthesopathy of the extensor digitorum has yet to be discovered...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29686442/ultrasound-as-a-useful-tool-to-integrate-the-clinical-assessment-of-nail-involvement-in-psoriatic-arthritis
#5
REVIEW
Jessica Gutierrez-Manjarrez, Marwin Gutierrez, Chiara Bertolazzi, Alfonso Afaro-Rodriguez, Carlos Pineda
Developing the skills to adequately assess nail lesions in psoriasis is mandatory for correct interpretation of the pathological features and to provide correct management of psoriatic patients. Although clinical assessment is part of an accurate diagnosis of nail psoriasis, recent advances in the field of imaging are generating growing interest among clinicians exploring its potential role for the assessment of nail psoriasis. We would like to address the attention to ultrasound (US), which is having an impact in different clinical scenarios such as diagnosis, prognosis, and treatment monitoring of nail involvement in psoriatic disease...
2018: Reumatologia
https://www.readbyqxmd.com/read/29673870/microstructural-alterations-in-the-onychomycotic-and-psoriatic-nail-relevance-in-drug-delivery
#6
Elena Cutrín Gómez, Soledad Anguiano Igea, M Begoña Delgado-Charro, José Luis Gómez Amoza, Francisco J Otero Espinar
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered structure. This work aimed to characterize the microstructure of the healthy, onychomycotic and psoriatic human nail using Raman spectroscopy, scanning electron microscopy, optical microscope profilometry and mercury intrusion porosimetry followed by analysis of the structure with PoreCor® software...
April 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29670773/psoriatic-arthritis-and-nail-psoriasis-in-a-patient-with-concomitant-atopic-dermatitis
#7
Gerhard Eichhoff, Noriko Soffi Harun
Coincidence of psoriasis and atopic dermatitis (AD) is considered to be very rare, as a result of the different underlying immunopathology. This case report describes a patient with long history of atopy and AD who developed psoriatic nail changes and psoriatic arthritis (PsA). The patient's skin, however, revealed only eczematous lesions without manifestation of psoriasis.
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29616495/role-of-methotrexate-in-the-management-of-psoriatic-arthritis
#8
Musaab Elmamoun, Vinod Chandran
Methotrexate is known to be safe and efficacious in the management of rheumatoid arthritis and psoriasis and thus has been used for the management of psoriatic arthritis despite a lack of evidence to support efficacy in psoriatic arthritis from randomized controlled trials. Although the largest randomized trial to date did not support its use as a disease-modifying therapy, observational studies have supported its role, and current treatment recommendations approve of its use as a first-line agent for the management of psoriatic arthritis with predominant peripheral arthritis...
April 3, 2018: Drugs
https://www.readbyqxmd.com/read/29573849/dactylitis-a-hallmark-of-psoriatic-arthritis
#9
REVIEW
Gurjit S Kaeley, Lihi Eder, Sibel Z Aydin, Marwin Gutierrez, Catherine Bakewell
OBJECTIVE: Dactylitis-long considered a hallmark clinical feature of psoriatic arthritis (PsA)-occurs in 16-49% of patients with PsA. In this review, we discuss the pathology of dactylitis in PsA and clinical and imaging tools used to diagnose and monitor dactylitis. METHODS: PubMed literature searches were conducted using the terms psoriatic arthritis, dactylitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, diagnosis, and/or monitoring of dactylitis in PsA, or if they discussed clinical or imaging indices used to assess dactylitis...
February 14, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29566966/considerations-for-the-definition-of-remission-criteria-in-psoriatic-arthritis
#10
REVIEW
Philip J Mease, Laura C Coates
OBJECTIVES: Psoriatic arthritis (PsA) is an autoimmune disease that can cause progressive structural damage of the joints and irreversible disability. The potentially achievable results of biologic therapy for PsA has led to the view that disease remission should be the goal of treatment. However, the heterogeneity of disease manifestations and need for validated outcome measures makes defining remission in PsA challenging. This article evaluates proposed criteria for defining remission in PsA and discusses how these criteria can be applied in clinical practice...
October 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29564871/long-term-treatment-of-psoriatic-patients-with-adalimumab-reduces-disease-severity-and-maintains-a-favorable-lipid-pattern-and-a-low-atherogenic-index
#11
Arianna Zangrilli, Mauro Bavetta, Martina Scaramella, Luca Bianchi
BACKGROUND: This retrospective study aimed to evaluate the long-term efficacy and effects on lipid profile and Atherogenic Index of antitumor necrosis factor (TNF)α therapy with adalimumab in patients with moderate-to-severe psoriasis or psoriatic arthritis. METHODS: Sixty-nine psoriatic patients treated with adalimumab 40 mg every other week were included. Patients were treated continuously for four years; study visits took place every 24 weeks. Disease severity (Psoriasis Area Severity Index [PASI], Nail Psoriasis Severity Index [NAPSI], articular pain intensity), disease burden (PSOdisk), serum lipid concentrations, Atherogenic Index, and inflammatory markers were assessed at each visit...
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29556416/4-year-results-from-the-rapid-psa-phase-3-randomised-placebo-controlled-trial-of-certolizumab-pegol-in-psoriatic-arthritis
#12
Désirée van der Heijde, Atul Deodhar, Oliver FitzGerald, Roy Fleischmann, Dafna Gladman, Alice B Gottlieb, Bengt Hoepken, Lars Bauer, Oscar Irvin-Sellers, Majed Khraishi, Luke Peterson, Anthony Turkiewicz, Jürgen Wollenhaupt, Philip J Mease
Objective: To report the efficacy, patient-reported, radiographic and safety outcomes of 4 years' certolizumab pegol (CZP) treatment in patients with psoriatic arthritis (PsA). Methods: RAPID-PsA (NCT01087788) was double-blind and placebo-controlled to Week 24, dose-blind to Week 48 and open-label (OL) to Week 216. Patients were randomised 1:1:1 to either placebo or CZP 200 mg every 2 weeks (Q2W) or 400 mg every 4 weeks (Q4W) (following 400 mg at Weeks 0/2/4)...
2018: RMD Open
https://www.readbyqxmd.com/read/29542417/cardiovascular-risk-markers-and-major-adverse-cardiovascular-events-in-psoriatic-arthritis-patients
#13
Rosario Peluso, Francesco Caso, Marco Tasso, Pasquale Ambrosino, Matteo Nicola, Dario Di Minno, Roberta Lupoli, Livio Criscuolo, Paolo Caso, Francesco Ursini, Antonio Del Puente, Raffaele Scarpa, Luisa Costa
BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis and leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and serologic features in addition to familial and genetic relationship. Beyond skin and joint involvement, psoriatic arthritis is characterized by a high prevalence of extra-articular manifestation and comorbidities, such as autoimmune, infectious and neoplastic diseases...
March 13, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29536977/intramatricial-injections-for-nail-psoriasis-an-open-label-comparative-study-of-triamcinolone-methotrexate-and-cyclosporine
#14
Jyotisterna Mittal, Bharat Bhushan Mahajan
BACKGROUND: One of the most effective options available for treating psoriatic fingernails is intramatricial injection of triamcinolone acetonide. Efficacies of intramatricial methotrexate and cyclosporine have not been comparatively evaluated to date. METHODS: Ninety fingernails in 17 patients were assigned to three groups of thirty nails each, and treated with intramatricial injections of triamcinolone acetonide (10 mg/ml), methotrexate (25 mg/ml) and cyclosporine (50 mg/ml) respectively...
March 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29531787/design-and-rationale-of-the-study-of-etanercept-and-methotrexate-in-combination-or-as-monotherapy-in-subjects-with-psoriatic-arthritis-seam-psa
#15
Philip J Mease, Dafna D Gladman, Ahmed S Samad, Laura C Coates, Lyrica X H Liu, Girish A Aras, David H Collier, James B Chung
Objective: To evaluate the efficacy of etanercept and methotrexate as monotherapies and as combination therapy in subjects with active psoriatic arthritis (PsA). Methods: The Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis (SEAM-PsA) is an ongoing, global, double-blind, 48-week, randomised, controlled study. Subjects are randomised (1:1:1) to etanercept monotherapy, methotrexate monotherapy or etanercept-methotrexate combination therapy...
2018: RMD Open
https://www.readbyqxmd.com/read/29531786/mri-of-psoriatic-nail-disease-pre-and-post-tnf-inhibitor-therapy-shows-persistent-subclinical-inflammation-after-6-months-despite-good-clinical-response
#16
Zoe Ash, Ai Lyn Tan, Richard J Hodgson, Andrew Grainger, Helena Marzo-Ortega, Dennis G McGonagle
No abstract text is available yet for this article.
2018: RMD Open
https://www.readbyqxmd.com/read/29469753/a-case-of-de-novo-palmoplantar-psoriasis-with-psoriatic-arthritis-and-autoimmune-hypothyroidism-after-receiving-nivolumab-therapy
#17
Marta Elosua-González, Ana Pampín-Franco, Ramón Mazzucchelli-Esteban, Xabier Mielgo-Rubio, Ximena Rodriguez-Vásquez, Elena García-Zamora, Jose Luis López-Estebaranz
Nivolumab, a monoclonal antibody against the programmed cell death protein 1 (PD-1), has shown promising results in patients with advanced malignancies, including melanoma, lung cancer, and renal cancer. Immune-related adverse events (irAEs) have been reported, including both organ-specific toxicities and skin toxicities. Herein, we report a case of predominantly palmoplantar psoriasis with severe nail involvement, psoriatic arthritis, and autoimmune hypothyroidism after receiving nivolumab treatment for lung cancer...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29449498/early-psoriatic-arthritis-versus-early-seronegative-rheumatoid-arthritis-role-of-dermoscopy-combined-with-ultrasonography-for-differential-diagnosis
#18
Alen Zabotti, Enzo Errichetti, Francesca Zuliani, Luca Quartuccio, Stefania Sacco, Giuseppe Stinco, Salvatore De Vita
OBJECTIVE: Exclusion of psoriatic skin/nail lesions is important in differentiating early seronegative rheumatoid arthritis (ERA) from early polyarticular psoriatic arthritis (EPsA) and such manifestations may go unnoticed in atypical or minimally expressed cases. The aim of this study is to assess the usefulness of integrated rheumatological-dermatological evaluation in highlighting dermatological lesions missed on rheumatological examination and to investigate the role of ultrasonography (US) and dermoscopy in improving the recognition of subclinical psoriatic findings...
May 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29364440/how-relevant-are-vascular-endothelial-growth-factor-and-intercellular-adhesion-molecule-in-the-systemic-capillary-leak-syndrome-of-psoriasis
#19
REVIEW
Aline Lopes Bressan, Daniele Pereira, Paula Mota Medeiros, Sueli Carneiro, Luna Azulay-Abulafia
Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29356051/optical-coherence-tomography-angiography-of-normal-skin-and-inflammatory-dermatologic-conditions
#20
Anthony J Deegan, Faezeh Talebi-Liasi, Shaozhen Song, Yuandong Li, Jingjiang Xu, Shaojie Men, Michi M Shinohara, Mary E Flowers, Stephanie J Lee, Ruikang K Wang
BACKGROUND: In clinical dermatology, the identification of subsurface vascular and structural features known to be associated with numerous cutaneous pathologies remains challenging without the use of invasive diagnostic tools. OBJECTIVE: To present an advanced optical coherence tomography angiography (OCTA) method to directly visualize capillary-level vascular and structural features within skin in vivo. METHODS: An advanced OCTA system with a 1310 nm wavelength was used to image the microvascular and structural features of various skin conditions...
March 2018: Lasers in Surgery and Medicine
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