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https://www.readbyqxmd.com/read/28804947/periodontitis-and-non-alcoholic-fatty-liver-disease-a-population-based-cohort-investigation-in-the-study-of-health-in-pomerania
#1
Aderonke A Akinkugbe, Gary D Slade, A Sidney Barritt, Steven Offenbacher, Astrid Petersmann, Thomas Kocher, Markus M Lerch, Julia Mayerle, Henry Völzke, Gerardo Heiss, Birte Holtfreter
Non-alcoholic fatty liver disease (NAFLD) affects 20-30% of adults with risk factors like obesity and insulin resistance putatively acting through chronic low-grade inflammation. Because periodontitis elicits low-grade inflammation, we hypothesized that it could contribute to NAFLD occurrence. Objective To investigate epidemiologic associations between periodontitis and the incidence of NAFLD among 2,623 participants of the Study of Health in Pomerania METHODS: Periodontitis at baseline was defined as the percentage of sites (0%, 1-30%, ≥30%) with 1) clinical attachment level (CAL) ≥3mm; 2) probing pocket depth (PD) ≥4mm...
August 14, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28764594/intraoperative-endoscopic-ultrasound-guidance-for-laparoscopic-excision-of-invisible-symptomatic-deep-intramural-myomas
#2
Bulent Urman, Aysen Boza, Baris Ata, Sertan Aksu, Tonguc Arslan, Cagatay Taskiran
The aim of this study was to evaluate the feasibility of intraoperative endoscopic ultrasound guidance for excision of symptomatic deep intramural myomas that are not otherwise visible at laparoscopy. Seventeen patients with symptomatic deep intramural myomas who underwent laparoscopic myomectomy with intraoperative endoscopic ultrasound guidance were followed up and reported. All myomas were removed successfully. The endometrium was breached in one patient. All patients were relieved of their symptoms and three patients presenting with infertility conceived...
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28748686/invisible-dermatoses-from-the-perspective-of-the-dermatopathologist-original-observations-and-novel-concepts
#3
Carlo Tomasini
The phrase 'invisible dermatoses' has been used in two different contexts: 1) Invisible dermatoses to the clinician, i.e., diseases with no significant clinical features, 2) invisible dermatoses to the pathologist. These latter comprise a wide spectrum of entities which present with definite and obvious clinical features, but subtle or hidden histological features and are therefore "invisible" histologically. Diagnosis of such diseases represents a great challenge to both the dermatologist and dermatopathologist...
July 26, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28747962/factors-related-to-the-diagnostic-yield-of-flexible-bronchoscopy-without-guidance-in-bronchoscopically-invisible-peripheral-lung-lesions
#4
Hye Seon Kang, Jick Hwan Ha, Hyeon Hui Kang, Chang Dong Yeo, Chin Kook Rhee, Sung Kyoung Kim, Hwa Sik Moon, Sang Haak Lee
BACKGROUND: We aimed to analyze the factors predicting the diagnostic performance of flexible bronchoscopy without guidance in peripheral lung lesions that are endoscopically invisible. METHODS: This was a retrospective study conducted in St. Paul's Hospital, The Catholic University of Korea, between January 2007 and March 2013. We included all patients who received bronchoscopy during this period. The analyzed variables were age, sex, the etiology of the lesion, lesion size, distance from the pleura, and presence of the bronchus sign...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28744325/3-d-electrochemical-impedance-spectroscopy-mapping-of-arteries-to-detect-metabolically-active-but-angiographically-invisible-atherosclerotic-lesions
#5
René R Sevag Packard, Yuan Luo, Parinaz Abiri, Nelson Jen, Olcay Aksoy, William M Suh, Yu-Chong Tai, Tzung K Hsiai
We designed a novel 6-point electrochemical impedance spectroscopy (EIS) sensor with 15 combinations of permutations for the 3-D mapping and detection of metabolically active atherosclerotic lesions. Two rows of 3 stretchable electrodes circumferentially separated by 120° were mounted on an inflatable balloon for intravascular deployment and endoluminal interrogation. The configuration and 15 permutations of 2-point EIS electrodes allowed for deep arterial penetration via alternating current (AC) to detect varying degrees of lipid burden with distinct impedance profiles (Ω)...
2017: Theranostics
https://www.readbyqxmd.com/read/28685596/amelanotic-lentigo-maligna-melanoma-mohs-surgery-as-the-definitive-treatment-of-an-invisible-tumour
#6
Marisa Grace Ponzo, Richard Ian Crawford, Irèn Kossintseva
Amelanotic lentigo maligna melanoma represents <2% of melanomas. Diagnosis is delayed owing to the lack of lesion pigmentation and advanced disease at presentation. Excision with appropriate margins is the treatment standard, but the starting point for such margins is often unclear. We describe 2 patients with amelanotic melanoma treated by Mohs micrographic surgery (MMS) that would not have been cleared by wide local excision alone and provide an extensive review of the literature. Both patients presented with histologic diagnoses of malignant melanoma, one with a barely perceptible biopsy site scar on the left infraorbital cheek/lower eyelid (Breslow 1...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28678538/what-they-don-t-see
#7
Cody M Clemens
The author is currently living with a chronic autoimmune disease known as Hashimoto's Thyroiditis, which caused his hypothyroidism. Although this disease is most common in middle-aged women, he was diagnosed at age 23. This disease is unique, because it is not entirely visible to others. In this piece, he presents a personal narrative of his diagnosis process and utilizes poetic inquiry to demonstrate to readers what "they," meaning individuals without an invisible chronic autoimmune disease, don't see.
July 5, 2017: Health Communication
https://www.readbyqxmd.com/read/28619043/effect-of-transcutaneous-electrical-stimulation-treatment-on-lower-urinary-tract-symptoms-after-class-iii-radical-hysterectomy-in-cervical-cancer-patients-study-protocol-for-a-multicentre-randomized-controlled-trial
#8
Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-Ting Cao, Xin Yang, Jing-Song Han, Yang-Feng Wu, Kathleen H Reilly, Jian-Liu Wang
BACKGROUND: Class III radical hysterectomy (RH III)_plus pelvic lymphadenectomy is the standard surgery for early stage cervical cancer (CC) patients, the 5 year survival rate is about 90%, but pelvic floor disorders especially bladder dysfunction are common due to damaged vessels and nerve fibers following surgery. Transcutaneous electrical stimulation (TENS) treatment has been used to treat bladder disorders for many years, but its effect on cervical cancer patients, the best treatment time point and stimulated protocol, had never been assessed...
June 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28608328/towards-accurate-and-precise-t-1-and-extracellular-volume-mapping-in-the-myocardium-a-guide-to-current-pitfalls-and-their-solutions
#9
REVIEW
Donnie Cameron, Vassilios S Vassiliou, David M Higgins, Peter D Gatehouse
Mapping of the longitudinal relaxation time (T 1) and extracellular volume (ECV) offers a means of identifying pathological changes in myocardial tissue, including diffuse changes that may be invisible to existing T 1-weighted methods. This technique has recently shown strong clinical utility for pathologies such as Anderson-Fabry disease and amyloidosis and has generated clinical interest as a possible means of detecting small changes in diffuse fibrosis; however, scatter in T 1 and ECV estimates offers challenges for detecting these changes, and bias limits comparisons between sites and vendors...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28605444/is-elimination-of-hepatitis-c-from-the-uk-by-2030-a-realistic-goal
#10
Will Gelson, Graeme Alexander
Introduction: Highly effective, combination therapy for chronic hepatitis C virus (HCV) infection is now available. Current cure rates are close to 100% and applicable to all patients irrespective of race, age, severity of liver disease or viral genotype. Remarkably for persistent infection, current treatment is recommended for as little as 12 weeks; recent studies suggest even shorter courses. In contrast to interferon-based therapy, present regimens have few side effects and serious adverse events are rare...
June 9, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28604289/a-suitable-soil-plague-s-urban-breeding-grounds-at-the-dawn-of-the-third-pandemic
#11
Christos Lynteris
A pressing question during the first half-decade of the third plague pandemic (1894-9) was what was a 'suitable soil' for the disease. The question related to plague's perceived ability to disappear from a given city only to reappear at some future point; a phenomenon that became central to scientific investigations of the disease. However, rather than this simply having a metaphorical meaning, the debate around plague's 'suitable soil' actually concerned the material reality of the soil itself. The prevalence of plague in the working-class neighbourhood of Taipingshan during the first major outbreak of the pandemic, in 1894 in Hong Kong, led to an extensive debate regarding the ability of the soil to harbour and even spread the disease...
July 2017: Medical History
https://www.readbyqxmd.com/read/28559085/clinically-focused-molecular-investigation-of-1000-consecutive-families-with-inherited-retinal-disease
#12
Edwin M Stone, Jeaneen L Andorf, S Scott Whitmore, Adam P DeLuca, Joseph C Giacalone, Luan M Streb, Terry A Braun, Robert F Mullins, Todd E Scheetz, Val C Sheffield, Budd A Tucker
PURPOSE: To devise a comprehensive multiplatform genetic testing strategy for inherited retinal disease and to describe its performance in 1000 consecutive families seen by a single clinician. DESIGN: Retrospective series. PARTICIPANTS: One thousand consecutive families seen by a single clinician. METHODS: The clinical records of all patients seen by a single retina specialist between January 2010 and June 2016 were reviewed, and all patients who met the clinical criteria for a diagnosis of inherited retinal disease were included in the study...
May 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28501996/application-of-hydrogel-nanoparticles-for-the-capture-concentration-and-preservation-of-low-abundance-biomarkers
#13
Ruben Magni, Alessandra Luchini
In the recent years, a lot of emphasis has been placed on the discovery and detection of clinically relevant biomarkers. Biomarkers are crucial for the early detection of several diseases, and they play an important role in the improvement of current treatments, thus reducing patient mortality rate. Because biofluids account to 60% of the body mass, they represent a goldmine of significant biomarkers. Unfortunately, because of their low concentration in body fluids, their lability, and the presence of high abundance proteins (i...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28488844/mri-in-prostate-cancer-detection-and-management-a-systematic-review
#14
Fabio Monni, Paolo Fontanella, Angelica Grasso, Peter Wiklund, Yen-Chuan Ou, Marco Randazzo, Bernardo Rocco, Emanuele Montanari, Giampaolo Bianchi
INTRODUCTION: The aim of our work was to evaluate the role of multi-parametric MRI (mpMRI) in detection and management of prostate cancer (PC); specifically investigating the efficacy of mpMRI-based biopsy techniques in terms of diagnostic yield of significant prostate neoplasm and the improved management of patient who choose conservative treatments or active surveillance. EVIDENCE ACQUISITION: A systematic and critical analysis through Medline, Embase, Scopus and Web of Science databases was carried out in March 2016, following the PRISMA ("Preferred Reporting Items for Systematic Reviews and Meta-Analyses") statement...
May 8, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28459041/advancing-cancer-therapy-with-present-and-emerging-immuno-oncology-approaches
#15
REVIEW
Jeff Kamta, Maher Chaar, Anusha Ande, Deborah A Altomare, Sihem Ait-Oudhia
Immuno-oncology (I-O) is a young and growing field on the frontier of cancer therapy. Contrary to cancer therapies that directly target malignant cells, I-O therapies stimulate the body's immune system to target and attack the tumor, which is otherwise invisible to, or inhibiting the immune response. To this end, several methods have been developed: First, passive therapies that enable T-cells to fight the tumor without direct manipulation, typically through binding and modifying the intracellular signaling of surface receptors...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28453059/-public-health-in-the-health-disease-continuum-an-analysis-from-a-professional-perspective
#16
Valeria Santoro-Lamelas
Objective To explore the components that health professionals use to build and define the concept of Public Health as a specific area of knowledge and intervention within public health policies. Method A qualitative analysis of content was performed based on 20 semi-structured interviews with health professionals participating in the demonstration project conducted by the Public Health Agency of Garrotxa in Catalonia, Spain (2009-2012). Results Health professionals use the health-disease continuum to provide guidance to all State policies on health: public health is usually related to health and care regarding disease...
August 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28441067/anterior-segment-optical-coherence-tomography-angiography-for-identification-of-iris-vasculature-and-staging-of-iris-neovascularization-a-pilot-study
#17
Philipp K Roberts, Debra A Goldstein, Amani A Fawzi
Purpose/Aim of the study: To assess the ability of optical coherence tomographic angiography (OCTA) to visualize the normal iris vasculature as well as neovascularization of the iris (NVI). MATERIALS AND METHODS: Study participants with healthy eyes, patients at risk of NVI development and patients with active or regressed NVI were consecutively included in this cross-sectional observational study. Imaging was performed using a commercially available OCTA system (RTVue- XR Avanti, Optovue Inc...
August 2017: Current Eye Research
https://www.readbyqxmd.com/read/28333581/the-social-construction-of-fibromyalgia-as-a-health-problem-from-the-perspective-of-policies-professionals-and-patients
#18
Erica Briones-Vozmediano
BACKGROUND: Fibromyalgia is a painful chronic disease, suffered mainly by women, that consolidates a number of symptoms and skeletal muscle issues which are little understood. OBJECTIVES: To explore the social construction of FM from the perspective of health policies, patients, and health professionals involved in their medical attention. METHODS: I) Policy review of national and regional health plans in a national and international context, the clinical protocols for fibromyalgia in Spain, and the Parliamentary initials in the European and Spanish context; and ii) Qualitative study involving 28 personal interviews with 16 fibromyalgia patients and 12 interviews with health care professionals in Spain...
2017: Global Health Action
https://www.readbyqxmd.com/read/28302650/erratum-2016-presidential-address-diabetes-at-212%C3%A2-confronting-the-invisible-disease-diabetes-care-2016-39-1657-1663
#19
Desmond Schatz
No abstract text is available yet for this article.
May 2017: Diabetes Care
https://www.readbyqxmd.com/read/28289480/ultrasound-elastography-for-determination-of-the-age-of-venous-thrombi-evaluation-of-thrombus-evolution-in-patients-after-sclerotherapy
#20
Łukasz Paluch, Ewa Nawrocka-Laskus, Agnieszka Dąbrowska, Tadeusz Popiela, Jerzy Walecki
BACKGROUND: Venous thrombosis is a multicausal disease involving intravenous clot formation. It may occur spontaneously or after provoking events, such as traumatic injuries to the pelvis, upper and lower extermities, immobilization, intravascular procedures, including venous catheterization or injection. Color Doppler ultrasonography is a rapid and non-invasive technique for evaluation of venous disease. It is a very sensitive method for detection of thrombi, but has some limitations, e...
2017: Polish Journal of Radiology
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