keyword
MENU ▼
Read by QxMD icon Read
search

Invisible disease

keyword
https://www.readbyqxmd.com/read/29038298/subversion-of-nk-cell-and-tnf-alpha-immune-surveillance-drives-tumor-recurrence
#1
Timothy Kottke, Laura Evgin, Kevin G Shim, Diana Rommelfanger, Nicolas Boisgerault, Shane Zaidi, Rosa Maria Diaz, Jill Thompson, Elizabeth Ilett, Matt Coffey, Peter Selby, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard Vile
Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment resistant, immune-invisible recurrences has major clinical significance. We show here that this transition is mediated through the subversion of two key elements of innate immune surveillance. In the first, the role of TNFalpha changes from an antitumor effector against primary tumors into a growth promoter for MRD. Second, whereas primary tumors induced a natural killer (NK)-mediated cytokine response characterized by low IL6 and elevated IFNgamma, PD-L1hi MRD cells promoted the secretion of IL6 but minimal IFNgamma, inhibiting both NK cell and T-cell surveillance...
October 15, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29030241/discovery-of-hidden-allosteric-sites-as-novel-targets-for-allosteric-drug-design
#2
REVIEW
Shaoyong Lu, Mingfei Ji, Duan Ni, Jian Zhang
Hidden allosteric sites, as a novel type of allosteric site, are invisible in ligand-unbound (apo) crystal structures, but can emerge in ligand-bound (holo) crystal structures when a specific ligand binds to, and stabilizes, a unique conformation favored by the ligand. However, the identification of these sites is a significant challenge. Several computational and experimental approaches have been developed to identify such sites in proteins. Here, we outline these approaches, with a focus on examples of the successful use of such techniques...
October 10, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28950835/determinants-of-uptake-of-hepatitis-b-testing-and-healthcare-access-by-migrant-chinese-in-the-england-a-qualitative-study
#3
Andrew Chee Keng Lee, Alicia Vedio, Eva Zhi Hong Liu, Jason Horsley, Amrita Jesurasa, Sarah Salway
BACKGROUND: Global migration from hepatitis B endemic countries poses a significant public health challenge in receiving low-prevalence countries. In the UK, Chinese migrants are a high risk group for hepatitis B. However, they are an underserved population that infrequently accesses healthcare. This study sought to increase understanding of the determinants of hepatitis B testing and healthcare access among migrants of Chinese ethnicity living in England. METHODS: We sought to obtain and integrate insights from different key stakeholders in the system...
September 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28934765/qualitative-study-the-experience-and-impact-of-living-with-behcet-s-syndrome
#4
Vicky Tai, Karen Lindsay, Joanne L Sims, Fiona M McQueen
AIM: Behcet's syndrome is a rare chronic multisystemic vasculitis of unknown aetiology, is unpredictable and can cause life-threatening complications. This qualitative study aims to explore the experiences of patients living with Behcet's syndrome in New Zealand. METHODS: Eight English-speaking patients participated in in-depth semi-structured interviews about their experiences of living with Behcet's syndrome. Interviews were recorded and transcribed. Data were analysed using a general inductive thematic approach...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28931667/an-invisible-disease-severe-asthma-is-more-than-just-bad-asthma
#5
EDITORIAL
Sally E Wenzel, Sheila Brillhart, Kristin Nowack
No abstract text is available yet for this article.
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28922442/volumetric-laser-endomicroscopy-for-barrett-s-esophagus-looking-at-the-fine-print
#6
REVIEW
Deepanshu Jain, Sanna Fatima, Shilpa Jain, Shashideep Singhal
Barrett's esophagus (BE) is a premalignant condition. The incidence of adenocarcinoma in BE has been reported to be between 0.1-3%. Dysplasia in BE is patchy and extensive biopsy sampling is labor intensive, low yield and does not eliminate the sampling error completely. Volumetric laser endomicroscopy (VLE) is expected to enable endoscopists to do targeted biopsy of dysplastic/cancerous lesions (not visible on white light endoscopy) among patients with BE. We reviewed 7 studies with a total of 62 subjects who had undergone VLE...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28904811/which-symptoms-contribute-the-most-to-patients-perception-of-health-in-multiple-sclerosis
#7
Rivka Green, Gary Cutter, Michael Friendly, Ilya Kister
BACKGROUND: Multiple sclerosis is a polysymptomatic disease. Little is known about relative contributions of the different multiple sclerosis symptoms to self-perception of health. OBJECTIVES: To investigate the relationship between symptom severity in 11 domains affected by multiple sclerosis and self-rated health. METHODS: Multiple sclerosis patients in two multiple sclerosis centers assessed self-rated health with a validated instrument and symptom burden with symptoMScreen, a validated battery of Likert scales for 11 domains commonly affected by multiple sclerosis...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28898327/-transition-from-pediatric-to-adult-health-care-services-for-adolescents-with-chronic-diseases-recommendations-from-the-adolescent-branch-from-sociedad-chilena-de-pediatr%C3%A3-a
#8
Tamara Zubarew, Loreto Correa, Paula Bedregal, Carolina Besoain, Alejandro Reinoso, Macarena Velarde, María Teresa Valenzuela, Carolina Inostroza
The Adolescent Branch from Sociedad Chilena de Pediatría supports the implementation of planned programs for transition from child to adult health centers, oriented to adolescents with chronic diseases, in order to ensure an appropriate follow-up and a high-quality health care. Recommendations for care are set out in the FONIS and VRI PUC project carried out by the Division of Pediatrics of the Universidad Católica de Chile: “Transition process from pediatric to adult services: perspectives of adolescents with chronic diseases, caregivers and health professionals”, whose goal was to describe the experience, barriers, critical points, and facilitators in the transition process...
2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28882578/managing-ulcerative-colitis-patients-with-endoscopically-invisible-low-grade-dysplasia
#9
Ben Parker, James Buchanan, Sarah Wordsworth, Satish Keshav, Bruce George, James E East
BACKGROUND AND AIMS: There is uncertainty regarding the optimal management of endoscopically invisible ("flat") low grade dysplasia in ulcerative colitis. Such a finding does not currently provide an automatic indication for colectomy; however, a recommendation of surveillance instead of surgery is controversial. The aim of this study was to determine the clinical and cost-effectiveness of colonoscopic surveillance versus colectomy for endoscopically invisible low-grade dysplasia of the colon in ulcerative colitis...
September 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28856871/pfannenstiel-laparoendoscopic-reduced-port-bilateral-radical-nephrectomy-for-a-patient-with-renal-cell-carcinoma-undergoing-hemodialysis
#10
Takeo Nomura, Mutsushi Yamasaki, Kohei Takei, Fuminori Sato, Toshiro Terachi, Hiromitsu Mimata
We performed Pfannenstiel laparoendoscopic reduced-port bilateral radical nephrectomy on a patient with renal cell carcinoma undergoing hemodialysis. A 4-cm Pfannenstiel incision was made, and a GelPOINT access was inserted. Three trocars were placed through the access platform, and additional 5- and 3-mm trocars were inserted in the umbilicus and paraumbilical area, respectively. After left nephrectomy, right nephrectomy was successfully completed in 401 min, with an estimated blood loss of 70 mL. There were no intraoperative or postoperative complications, and the patient was discharged 10 days postoperatively...
August 30, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28846523/performing-pain-and-inflammation-rendering-the-invisible-visible
#11
Arseli Dokumaci
These drawings represent everyday experiences of an artist who has been living with rheumatoid arthritis since her teenage years. Over the course of 20 years, the disease has damaged a series of joints in her body. Pain and inflammation accompany the most mundane of her movements and gestures. Fatigue and side effects of medications are routine parts of life. None of her impairments are publicly recognized and duly accommodated, as she is not (yet) visibly disabled. Asking for a seat on the bus, for instance, turns into a thorough social negotiation, as does having to constantly remind people that she actually is disabled...
August 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28839393/invisible-lichen-planopilaris-unmasked-by-dermatoscopy
#12
Balakrishnan Nirmal, Renu George, Thomas Alex Kodiatte
Lichen planopilaris is a form of lymphocyte-mediated primary cicatricial alopecia characterized by perifollicular scaling progressing to patches of alopecia depending on the clinical variant. The course is relentlessly progressive and chronic. Hence, early diagnosis and institution of therapy are imperative to halt the disease progress. Although definitive diagnosis is made by scalp biopsy, the detection is usually delayed. Dermatoscopy helps in early recognition of this condition which at that stage is clinically invisible...
April 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28838456/successful-treatment-of-stricture-of-duct-to-duct-biliary-anastomosis-after-living-donor-liver-transplantation-of-the-left-lobe-a%C3%A2-case%C3%A2-report
#13
Y Nakaseko, H Shiba, E Yamanouchi, Y Takano, T Sakamoto, H Imazu, H Ashida, K Yanaga
Biliary complications, such as stricture or obstruction, after living-donor liver transplantation (LDLT) remain major problems to be solved. Magnetic compression anastomosis (MCA) is a minimally invasive method of biliary anastomosis without surgery in patients with biliary stricture or obstruction. A 66-year-old woman had undergone LDLT for end-stage liver disease for primary biliary cholangitis 20 months previously at another hospital. Computerized tomography showed dilation of the intrahepatic bile duct (B2)...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28830058/contrast-enhanced-ultrasonography-of-the-liver-using-sonovue
#14
Giovanna Ferraioli, Maria Franca Meloni
This review focuses on the use of contrast-enhanced ultrasonography (CEUS) with SonoVue Epub ahead of print (Bracco Imaging) for the diagnosis of focal liver lesions (FLLs), guidance during ablative treatment, and follow-up of liver tumors. Multicenter trials have shown that the performance of CEUS for the characterization of FLLs is similar to that of contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. CEUS with SonoVue has been effectively used for guiding the percutaneous treatment of malignant liver tumors that are invisible or poorly visualized in traditional gray-scale ultrasonography...
July 12, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28827275/living-with-chronic-migraine-a-qualitative-study-on-female-patients-perspectives-from-a-specialised-headache-clinic-in-spain
#15
Domingo Palacios-Ceña, Beatriz Neira-Martín, Lorenzo Silva-Hernández, Diego Mayo-Canalejo, Lidiane Lima Florencio, César Fernández-de-Las-Peñas, Héctor García-Moreno, David García-Azorín, María Luz Cuadrado
OBJECTIVES: The aim of this study was to explore the views and experiences of a group of Spanish women suffering from chronic migraine (CM). SETTING: Headache clinic at a university hospital in Madrid (Spain). PARTICIPANTS: Purposeful sampling of patients that attended a specialised headache clinic for the first time between June 2016 and February 2017 was performed. The patients included were females aged 18-65 and with positive diagnoses of CM according to the International Classification of Headache disorders (third edition, beta version), with or without medication overuse...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28804947/periodontitis-and-non-alcoholic-fatty-liver-disease-a-population-based-cohort-investigation-in-the-study-of-health-in-pomerania
#16
Aderonke A Akinkugbe, Gary D Slade, A Sidney Barritt, Stephen R Cole, Steven Offenbacher, Astrid Petersmann, Thomas Kocher, Markus M Lerch, Julia Mayerle, Henry Völzke, Gerardo Heiss, Birte Holtfreter
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 20%-30% of adults with risk factors like obesity and insulin resistance putatively acting through chronic low-grade inflammation. Because periodontitis elicits low-grade inflammation, we hypothesized that it could contribute to NAFLD occurrence. OBJECTIVE: To investigate epidemiologic associations between periodontitis and the incidence of NAFLD among 2,623 participants of the Study of Health in Pomerania...
November 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28764594/intraoperative-endoscopic-ultrasound-guidance-for-laparoscopic-excision-of-invisible-symptomatic-deep-intramural-myomas
#17
Bulent Urman, Aysen Boza, Baris Ata, Sertan Aksu, Tonguc Arslan, Cagatay Taskiran
The aim of this study was to evaluate the feasibility of intraoperative endoscopic ultrasound guidance for excision of symptomatic deep intramural myomas that are not otherwise visible at laparoscopy. Seventeen patients with symptomatic deep intramural myomas who underwent laparoscopic myomectomy with intraoperative endoscopic ultrasound guidance were followed up and reported. All myomas were removed successfully. The endometrium was breached in one patient. All patients were relieved of their symptoms and three patients presenting with infertility conceived...
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28748686/invisible-dermatoses-from-the-perspective-of-the-dermatopathologist-original-observations-and-novel-concepts
#18
Carlo Tomasini
The phrase 'invisible dermatoses' has been used in two different contexts: 1) Invisible dermatoses to the clinician, i.e., diseases with no significant clinical features, 2) invisible dermatoses to the pathologist. These latter comprise a wide spectrum of entities which present with definite and obvious clinical features, but subtle or hidden histological features and are therefore "invisible" histologically. Diagnosis of such diseases represents a great challenge to both the dermatologist and dermatopathologist...
July 26, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28747962/factors-related-to-the-diagnostic-yield-of-flexible-bronchoscopy-without-guidance-in-bronchoscopically-invisible-peripheral-lung-lesions
#19
Hye Seon Kang, Jick Hwan Ha, Hyeon Hui Kang, Chang Dong Yeo, Chin Kook Rhee, Sung Kyoung Kim, Hwa Sik Moon, Sang Haak Lee
BACKGROUND: We aimed to analyze the factors predicting the diagnostic performance of flexible bronchoscopy without guidance in peripheral lung lesions that are endoscopically invisible. METHODS: This was a retrospective study conducted in St. Paul's Hospital, The Catholic University of Korea, between January 2007 and March 2013. We included all patients who received bronchoscopy during this period. The analyzed variables were age, sex, the etiology of the lesion, lesion size, distance from the pleura, and presence of the bronchus sign...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28744325/3-d-electrochemical-impedance-spectroscopy-mapping-of-arteries-to-detect-metabolically-active-but-angiographically-invisible-atherosclerotic-lesions
#20
René R Sevag Packard, Yuan Luo, Parinaz Abiri, Nelson Jen, Olcay Aksoy, William M Suh, Yu-Chong Tai, Tzung K Hsiai
We designed a novel 6-point electrochemical impedance spectroscopy (EIS) sensor with 15 combinations of permutations for the 3-D mapping and detection of metabolically active atherosclerotic lesions. Two rows of 3 stretchable electrodes circumferentially separated by 120° were mounted on an inflatable balloon for intravascular deployment and endoluminal interrogation. The configuration and 15 permutations of 2-point EIS electrodes allowed for deep arterial penetration via alternating current (AC) to detect varying degrees of lipid burden with distinct impedance profiles (Ω)...
2017: Theranostics
keyword
keyword
100543
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"