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Invisible disease

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https://www.readbyqxmd.com/read/29911591/although-unseen-chronic-pain-is-real-a-phenomenological-study
#1
Tapio Ojala, Arja Häkkinen, Jaro Karppinen, Kirsi Sipilä, Timo Suutama, Arja Piirainen
Background Research has emphasised the essential role of psychosocial risk factors in chronic pain. In practice, pain is usually verified by identifying its physical cause. In patients without any distinct pathology, pain is easily defined as imaginary pain. The aim of this qualitative study was to explore the invisibility of chronic pain, from the patients' perspective. Methods Thirty-four participants with chronic pain were interviewed. The mean age of the participants was 48 years, and 19 of them were women...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29907951/analysis-of-human-c24-bile-acids-metabolome-in-serum-and-urine-based-on-enzyme-digestion-of-conjugated-bile-acids-and-lc-ms-determination-of-unconjugated-bile-acids
#2
Pingping Zhu, Jian Zhang, Yujie Chen, Shanshan Yin, Mingming Su, Guoxiang Xie, Kim L R Brouwer, Changxiao Liu, Ke Lan, Wei Jia
Host-gut microbiota metabolic interactions are closely associated with health and disease. A manifestation of such co-metabolism is the vast structural diversity of bile acids (BAs) involving both oxidative stereochemistry and conjugation. Herein, we describe the development and validation of a LC-MS-based method for the analysis of human C24 BA metabolome in serum and urine. The method has high throughput covering the discrimination of oxidative stereochemistry of unconjugated species in a 15-min analytical cycle...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29897342/motion-artifacts-in-standard-clinical-setting-obscure-disease-specific-differences-in-quantitative-susceptibility-mapping
#3
Jakob Meineke, Fabian Wenzel, Matteo de Marco, Annalena Venneri, Daniel J Blackburn, Kevin Teh, Iain D Wilkinson, Ulrich Katscher
As Quantitative Susceptibility Mapping (QSM) is maturing, more clinical applications are being explored. With this comes the question whether QSM is sufficiently robust and reproducible to be directly used in a clinical setting where patients are possibly not cooperative and/or unable to suppress involuntary movements sufficiently.
 Subjects and Methods: Twenty-nine patients with Alzheimer's Disease (AD), 31 patients with Mild Cognitive Impairment (MCI) and 41 healthy controls (HC) were scanned on a 3T scanner, including a multi-echo gradient-echo sequence for QSM and an inversion-prepared segmented gradient-echo sequence (T1-TFE, MPRAGE)...
June 13, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29895048/patient-associations-a-driving-force-for-rare-diseases-research-resilience-a-driving-force-for-patient-associations
#4
S Pulciani, E Nutile, D Taruscio
Until a few decades ago, Rare Diseases were relatively unknown. Their low prevalence made them invisible to public opinion, and were of little concern to researchers and pharmaceutical industries. Rare disease sufferers and their loved ones had become victims of the disease as their implications were overlooked. Consequently, some of these individuals formed associations and embarked on ways to change this situation of neglect they had found themselves, in finally having their rights recognized. These associations have over time gained important roles in planning public health and biomedical research, especially after the introduction of the Human Genome Project...
July 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29893437/social-adjustment-experiences-of-adolescents-with-tourette-syndrome
#5
Mei-Yin Lee, Huei-Shyong Wang, Chen-Jung Chen, Mei-Hua Lee
AIMS AND OBJECTIVES: To explore and describe the experience of social adjustment of adolescents with Tourette syndrome in Taiwan. BACKGROUND: Although Tourette syndrome is a non-life-threatening disease, the inherent difficulties in controlling tics and comorbidities can cause long-term physical and psychological issues, as well as social maladjustment among adolescents. Good social adjustment can promote mental health among adolescents. Currently, it is not clear how adolescents with Tourette syndrome can self-adjust and maintain harmonious social interaction with others...
June 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29733919/disruptions-of-brain-structural-network-in-end-stage-renal-disease-patients-with-long-term-hemodialysis-and-normal-appearing-brain-tissues
#6
Ming-Chung Chou, Chih-Hung Ko, Jer-Ming Chang, Tsyh-Jyi Hsieh
OBJECTIVE: End-stage renal disease (ESRD) patients on hemodialysis were demonstrated to exhibit silent and invisible white-matter alterations which would likely lead to disruptions of brain structural networks. Therefore, the purpose of this study was to investigate the disruptions of brain structural network in ESRD patients. MATERIALS AND METHODS: Thiry-three ESRD patients with normal-appearing brain tissues and 29 age- and gender-matched healthy controls were enrolled in this study and underwent both cognitive ability screening instrument (CASI) assessment and diffusion tensor imaging (DTI) acquisition...
May 4, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29729219/finding-invisible-quantitative-trait-loci-with-missing-data
#7
Iulian Gabur, Harmeet Singh Chawla, Xiwei Liu, Vinod Kumar, Sébastien Faure, Andreas von Tiedemann, Christophe Jestin, Emmanuelle Dryzska, Susann Volkmann, Frank Breuer, Régine Delourme, Rod Snowdon, Christian Obermeier
Evolutionary processes during plant polyploidisation and speciation have led to extensive presence-absence variation (PAV) in crop genomes, and there is increasing evidence that PAV associates with important traits. Today, high-resolution genetic analysis in major crops frequently implements simple, cost-effective, high-throughput genotyping from single nucleotide polymorphism (SNP) hybridization arrays, however these are normally not designed to distinguish PAV from failed SNP calls caused by hybridization artefacts...
May 5, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29720903/colorectal-cancer-in-inflammatory-bowel-disease
#8
REVIEW
Ryan W Stidham, Peter D R Higgins
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29718911/mental-distress-and-perceived-wealth-justice-and-freedom-across-eight-countries-the-invisible-power-of-the-macrosystem
#9
Saskia Scholten, Julia Velten, Jürgen Margraf
Health and well-being have been related to macro-level factors such as income, income inequality or socioeconomic status. With regard to the increasing burden of disease due to mental disorders worldwide, the association between the macrosystem and mental distress should be further explored, too. In this context, the subjective evaluation of the macrosystem might play an important role. In the present exploratory study, we assessed symptoms of depression, anxiety and stress as well as perceived wealth, justice and freedom in population-based surveys in Spain, France, Germany, Poland, Russia, Sweden, the United Kingdom and the United States of America (n ≈ 1000 per country)...
2018: PloS One
https://www.readbyqxmd.com/read/29701051/-development-of-the-connotation-of-deficiency-and-excess-and-acupuncture-reinforcing-and-reducing-theory
#10
Suyun Li
There are connotations on regulating deficiency and excess by acupuncture reinforcing and reducing in Neijing ( the Internal Canon of Medicine ), including regulating yin and yang , regulating blood and qi , regulating weakened body resistance and state of evil domination, regulating the deficiency and excess of syndrome. The deficiency and excess usually mean the objects received reinforcing and reducing, such as tangible blood stasis, pus, water, etc, and invisible qi . The deficiency and excess had always mean the symptoms of diseases since Nanjing ( Classic of Questioning ), and the reinforcing and reducing of acupuncture was regulating qi ...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29681710/possible-link-between-stress-related-factors-and-altered-body-composition-in-women-with-polycystic-ovarian-syndrome
#11
Barnali Ray Basu, Olivia Chowdhury, Sudip Kumar Saha
Background: Stress is an invisible factor affecting modern day living and is strongly associated with many disease pathogenesis including polycystic ovarian syndrome (PCOS) in women. PCOS is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic dysfunction and body composition alterations. Salivary amylase and cortisol are major stress mediators that have been implicated in PCOS. However, their role in altering body composition in PCOS is yet to be deciphered...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29627134/delivering-a-new-deal-of-kidney-health-opportunities-to-improve-outcomes-within-the-veterans-health-administration
#12
Susan T Crowley, Katherine Murphy
Just as the "New Deal" aimed to elevate the "forgotten man" of the Great Depression through governmental relief and reform, so does the Department of Veterans Affairs (VA) health care system aim to improve the health of veterans with the invisible illness of chronic kidney disease through a concerted series of health care delivery reforms. Augmenting its primary care platform with advances in informatics and health service delivery initiatives targeting kidney disease, the VA is changing how nephrology care is provided to veterans with the goal of optimized population kidney health...
April 4, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29626181/disability-in-adults-with-arthrogryposis-is-severe-partly-invisible-and-varies-by-genotype
#13
Shenhao Dai, Klaus Dieterich, Marie Jaeger, Bernard Wuyam, Pierre-Simon Jouk, Dominic Pérennou
OBJECTIVE: To understand the disability of adults with arthrogryposis multiplex congenita (AMC), a rare disease spectrum characterized by at least 2 joint contractures at birth in different body areas. METHODS: This is a retrospective analysis of data for unselected persons with AMC referred to the French center for adults with AMC from 2010 to 2016. All underwent a pluriprofessional systematic and comprehensive investigation of deficits, activity limitation, and participation restriction according to the International Classification of Functioning, Disability and Health and genetic analysis when indicated...
May 1, 2018: Neurology
https://www.readbyqxmd.com/read/29587813/use-patterns-use-values-and-management-of-afzelia-africana-sm-in-burkina-faso-implications-for-species-domestication-and-sustainable-conservation
#14
Larba Hubert Balima, Blandine Marie Ivette Nacoulma, Marius Rodrigue Mensah Ekué, François N'Guessan Kouamé, Adjima Thiombiano
BACKGROUND: The lack of literature on the interactions between indigenous people and the valuable agroforestry trees hinder the promotion of sustainable management of plant resources in West African Sahel. This study aimed at assessing local uses and management of Afzelia africana Sm. in Burkina Faso, as a prerequisite to address issues of domestication and sustainable conservation. METHODS: One thousand forty-four peoples of seven dominant ethnic groups were questioned in 11 villages through 221 semi-structured focus group interviews...
March 27, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29582632/accuracy-of-specimen-radiography-in-assessing-complete-local-excision-with-breast-conservation-surgery
#15
Saira Naz, Imrana Masroor, Shaista Afzal, Waseem Mirza, Sehrish Butt, Zafar Sajjad, Anwar Ahmad
Objective: The aim of this study was to evaluate the accuracy of “X- ray examination of surgically resected specimen‘‘ in assessing complete local excision (CLE). Materials and Methods: In this retrospective cross sectional study, data were collected for all female breast cancer cases who underwent breast-conserving surgery after needle localization of mammographically visible disease. Males, patients with mammographically invisible disease and cases with benign or inconclusive histopathology, those undergoing modified radical mastectomy and individuals with dense breast parenchyma were excluded...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29556354/genes-involved-in-prostate-cancer-progression-determine-mri-visibility
#16
Ping Li, Sungyong You, Christopher Nguyen, Yanping Wang, Jayoung Kim, Deepika Sirohi, Asha Ziembiec, Daniel Luthringer, Shih-Chieh Lin, Timothy Daskivich, Jonathan Wu, Michael R Freeman, Rola Saouaf, Debiao Li, Hyung L Kim
MRI is used to image prostate cancer and target tumors for biopsy or therapeutic ablation. The objective was to understand the biology of tumors not visible on MRI that may go undiagnosed and untreated. Methods: Prostate cancers visible or invisible on multiparametric MRI were macrodissected and examined by RNAseq. Differentially expressed genes (DEGs) based on MRI visibility status were cross-referenced with publicly available gene expression databases to identify genes associated with disease progression...
2018: Theranostics
https://www.readbyqxmd.com/read/29544782/automated-choroid-segmentation-of-three-dimensional-sd-oct-images-by-incorporating-edi-oct-images
#17
Qiang Chen, Sijie Niu, Wangyi Fang, Yuanlu Shuai, Wen Fan, Songtao Yuan, Qinghuai Liu
BACKGROUND AND OBJECTIVE: The measurement of choroidal volume is more related with eye diseases than choroidal thickness, because the choroidal volume can reflect the diseases comprehensively. The purpose is to automatically segment choroid for three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) images. METHODS: We present a novel choroid segmentation strategy for SD-OCT images by incorporating the enhanced depth imaging OCT (EDI-OCT) images...
May 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29544392/the-invisible-burden-of-violence-against-girls-and-young-women-in-mexico-1990-to-2015
#18
Martha P Romero Mendoza, Héctor Gómez-Dantes, Quetzaliztli Manríquez Montiel, Gabriela J Saldívar Hernández, Julio C Campuzano Rincón, Rafael Lozano, María Elena Medina-Mora Icaza
The increasing burden of interpersonal violence in women in Mexico is a neglected social and health problem that competes with other leading causes of premature death, disability, and health losses in young women. In this article, we focus on revealing the burden of violence in girls and young women and its implications for public policy. This study presents the subnational analysis of Mexico from the Global Burden of Disease study (1990-2015). The global study harmonized information of 195 countries and 79 risk factors...
March 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29473673/mississippian-subadults-from-the-middle-cumberland-and-eastern-regions-of-tennessee-biological-indicators-of-population-interaction
#19
Rebecca Scopa Kelso
OBJECTIVES: Human subadult skeletal remains can provide a unique perspective into biosocial aspects of Mississippian period population interactions within and between the Middle Cumberland (MCR) and Eastern Tennessee Regions (ETR). The majority of previous studies have concentrated on adult skeletal remains, leaving out a large and extremely important population segment. METHODS: Skeletal indicators of disease, growth, body proportions, and metabolic stress were collected from subadult remains from five archaeological sites over several temporal periods...
February 23, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29466516/-infoxication-in-health-health-information-overload-on-the-internet-and-the-risk-of-important-information-becoming-invisible
#20
Marcelo D Agostino, Felipe Medina Mejía, Myrna Martí, David Novillo-Ortiz, Flavio Hazrum, Federico G de Cosío
OBJECTIVE: The objectives of this study were to: 1) raise awareness of the volume of quality health information on the Internet; 2) explore perceptions of information professionals with regard to the use of qualified sources for health decision-making; and 3) make recommendations that facilitate strengthening health worker capacities and institutional competencies related to digital literacy. METHODS: A non-experimental, descriptive cross-sectional study was conducted with a non-probability sample of 32 information professionals from nine countries...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
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