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https://www.readbyqxmd.com/read/29457137/correcting-nonpathological-variation-in-longitudinal-parametric-response-maps-of-ct-scans-in-copd-subjects-spiromics
#1
Antonio Fernández-Baldera, Charles R Hatt, Susan Murray, Eric A Hoffman, Ella A Kazerooni, Fernando J Martinez, MeiLan K Han, Craig J Galbán
Small airways disease (SAD) is one of the leading causes of airflow limitations in patients diagnosed with chronic obstructive pulmonary disease (COPD). Parametric response mapping (PRM) of computed tomography (CT) scans allows for the quantification of this previously invisible COPD component. Although PRM is being investigated as a diagnostic tool for COPD, variability in the longitudinal measurements of SAD by PRM has been reported. Here, we show a method for correcting longitudinal PRM data because of non-pathological variations in serial CT scans...
September 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29433137/-the-invisibles-project-meeting-and-collaboration-of-public-health-and-volunteering-the-influenza-vaccination-experience-to-promote-the-health-of-the-socially-vulnerable-and-economically-disadvantaged-population
#2
Loris Pagano, Caterina Pizzutelli, Maria Maddalena Matarazzo, Gaia Monteleone, Damiano Pizzuti
Migration and the current European socioeconomic conditions necessitate an evaluation/assessment, as detailed as possible, of the spread of seasonal infectious diseases in order to reduce inequalities in the healthcare system. The "Scuola di Formazione in Medicina Generale" of Lazio, in collaboration with the Community of Sant'Egidio of Rome, organized an influenza/flu vaccination campaign for homeless people, migrants and the poor in order to check their health conditions and prevent the spread of the most common infectious diseases...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29408639/hepatitis-b-virus-does-not-interfere-with-innate-immune-responses-in-the-human-liver
#3
Aleksei Suslov, Tujana Boldanova, Xueya Wang, Stefan Wieland, Markus H Heim
BACKGROUND AND AIMS: Most viruses are detected at early stages of cell infection and induce an innate immune response mediated by production interferons (IFNs). IFNs induce expression of hundreds of IFN-stimulated genes (ISGs). Infection of chimpanzees with hepatitis C virus, but not hepatitis B virus (HBV), induces ISG expression in the liver. HBV might not induce an innate immune response because it is not detected by pattern recognition receptors (the stealth properties of HBV) or because HBV suppresses IFN production or signaling despite detection by pattern recognition receptors...
February 2, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29387453/advancing-care-for-family-caregivers-of-persons-with-dementia-through-caregiver-and-community-partnerships
#4
Carole L White, Kristen J Overbaugh, Carolyn E Z Pickering, Bridgett Piernik-Yoder, Debbie James, Darpan I Patel, Frank Puga, Lark Ford, James Cleveland
Background: There are currently 15 million Americans who provide over 80% of the care required by their family members with Alzheimer's disease and other dementias. Yet care for caregivers continues to be fragmented and few evidence-based interventions have been translated into routine clinical care and therefore remain inaccessible to most family caregivers. To address this gap, the Caring for the Caregiver program is being developed at UT Health San Antonio, School of Nursing to improve support services and health outcomes for family caregivers...
2018: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29385427/diagnostic-yield-of-dysplasia-in-polyp-adjacent-biopsies-for-patients-with-inflammatory-bowel-disease-a-cross-sectional-study
#5
Conor Lahiff, Lai Mun Wang, Simon P L Travis, James E East
Introduction: Patients with inflammatory bowel disease (IBD) undergoing polypectomy are recommended by current guidelines to have biopsies taken from adjacent mucosa to determine whether there is dysplasia present. With improvements in endoscopic imaging it is now possible to characterise colonic lesions with higher levels of confidence than previously. We reviewed the diagnostic yield of polyp-adjacent biopsies in IBD. Materials and Methods: A systematic search of our histopathology database revealed cases where polyps had been endoscopically resected or biopsied in patients with IBD...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29378311/high-risk-of-advanced-colorectal-neoplasia-in-patients-with-primary-sclerosing-cholangitis-associated-with-inflammatory-bowel-disease
#6
Shailja C Shah, Joren R Ten Hove, Daniel Castaneda, Carolina Palmela, Erik Mooiweer, Jean-Frédéric Colombel, Noam Harpaz, Thomas A Ullman, Ad A van Bodegraven, Jeroen M Jansen, Nofel Mahmmod, Andrea E van der Meulen-de Jong, Cyriel Y Ponsioen, Christine J van der Woude, Bas Oldenburg, Steven H Itzkowitz, Joana Torres
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC, termed PSC-IBD) are at increased risk for colorectal cancer (CRC), but their risk following a diagnosis of low-grade dysplasia (LGD) is not well described. We aimed to determine the rate of advanced colorectal neoplasia (aCRN), defined as high-grade dysplasia and/or colorectal cancer, following a diagnosis of indefinite dysplasia or LGD in this population. METHODS: We performed a retrospective, longitudinal study of 1911 patients with colonic IBD (293 with PSC and 1618 without PSC) who underwent more than 2 surveillance colonoscopies from 2000 through 2015 in the Netherlands or the United States (9265 patient-years of follow up)...
January 25, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29318004/poly-de-prescribing-to-treat-polypharmacy-efficacy-and-safety
#7
Doron Garfinkel
Background: The aim of this study was to evaluate efficacy and safety of poly-de-prescribing (PDP) based on the Garfinkel method in older people with polypharmacy. Methods: A longitudinal, prospective, nonrandomized study in Israel was carried out between 2009 and 2016. Comprehensive geriatric assessments were performed at home in people age ⩾66 years consuming ⩾6 prescription drugs. Exclusion criteria were life expectancy <6 months and a seeming unwillingness to cooperate (poor compliance)...
January 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29305937/of-mice-and-men-traces-of-life-in-the-death-registries-of-the-1630-plague-in-milano
#8
Alfonsina D'Amato, Gleb Zilberstein, Svetlana Zilberstein, Benedetto Luigi Compagnoni, Pier Giorgio Righetti
The death registries of the plague epidemic of 1630, stored at the Archivio di Stato of Milano, have been interrogated via the EVA film technology (ethyl vinyl acetate film studded with crushed strong anion and cation exchangers as well as C8 resins). The EVA diskettes have been left in contact with the lower right margins of 11 different pages pertaining to the peak months of the raging disease (June through end of September) for 60-90min and then the captured material, after elution and digestion, analysed by mass spectrometry...
January 3, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29248887/the-lived-experience-of-chronic-headache-a-systematic-review-and-synthesis-of-the-qualitative-literature
#9
Vivien P Nichols, David R Ellard, Frances E Griffiths, Atiya Kamal, Martin Underwood, Stephanie J C Taylor
OBJECTIVE: To systematically review the qualitative literature of the lived experience of people with a chronic headache disorder. BACKGROUND: Chronic headaches affect 3%-4% of the population. The most common chronic headache disorders are chronic migraine, chronic tension-type headache and medication overuse headache. We present a systematic review and meta-ethnographic synthesis of the lived experience of people with chronic headache. METHODS: We searched seven electronic databases, hand-searched nine journals and used a modified Critical Appraisal Skills Programme checklist to appraise study quality...
December 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29236927/making-the-invisible-visible-searching-for-human-t-cell-lymphotropic-virus-types-1-and-2-htlv-1-and-htlv-2-in-brazilian-patients-with-viral-hepatitis-b-and-c
#10
Adele Caterino-de-Araujo, Fabiana Aparecida Alves, Karoline Rodrigues Campos, Marcílio Figueiredo Lemos, Regina Célia Moreira
With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one)...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29191686/ct-features-of-hepatic-veno-occlusive-disease-a-meta-analysis
#11
Song Yang, Jing Wu, Si Lei
RATIONALE AND OBJECTIVE: The computed tomography (CT) features of hepatic veno-occlusive disease (HVOD) could play a role in its diagnosis. We aimed to perform a meta-analysis of studies examining the CT features of HVOD. METHODS: Relevant studies published up to May 3, 2017 were searched in major electronic databases. The extracted data included the proportion of various CT features in patients with HVOD. The meta-analysis was conducted using R 3.3.3 with the "meta" package...
November 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29168584/hemolysis-and-iga-antibodies-against-tissue-transglutaminase-when-are-antibody-test-results-no-longer-reliable
#12
Johannes Wolf, Norman Haendel, Johannes Remmler, Carl Elias Kutzner, Thorsten Kaiser, Thomas Mothes
BACKGROUND: Antibodies against tissue transglutaminase (TTG) of isotype IgA (IgA-aTTG) represent reliable diagnostic markers to confirm or exclude celiac disease (CD). Hemolysis (HL) is an important pre-analytical factor. HL can be quantified as HL index (HI) correlating with the concentration of free hemoglobin. TTG is abundant in erythrocytes and released upon HL. In immunoassays, the released TTG may interfere with binding of IgA-aTTG to the coated TTG. METHODS: We selected 17 HL-free sera from children with biopsy-confirmed CD: 7 with low-positive (1-5 multiples of upper limit of normal [×ULN]), 5 with intermediate (5-10 × ULN) and 5 with high IgA-aTTG (10-15 × ULN)...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29164836/power-controlled-temperature-guided-retinal-laser-therapy
#13
Alexander Baade, Claus von der Burchard, Meike Lawin, Stefan Koinzer, Benedikt Schmarbeck, Kerstin Schlott, Yoko Miura, Johann Roider, Reginald Birngruber, Ralf Brinkmann
Laser photocoagulation has been a treatment method for retinal diseases for decades. Recently, studies have demonstrated therapeutic benefits for subvisible effects. A treatment mode based on an automatic feedback algorithm to reliably generate subvisible and visible irradiations within a constant irradiation time is introduced. The method uses a site-individual adaptation of the laser power by monitoring the retinal temperature rise during the treatment using optoacoustics. This provides feedback to adjust the therapy laser power during the irradiation...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29153019/-the-actual-questions-of-the-care-of-rare-diseases
#14
Gábor Pogány
The aim was to present the actual situation of rare diseases, especially to characterize the circumstances in Hungary. The most important developments were summarized which could help the care of rare disease patients in the everyday practice. There are around 800 000 patients with rare diseases in Hungary. The lack of information leads to "invisibility" for the health and social care system (most of them without ICD code). Therefore, these patients still have a huge disadvantage even when compared to the patients of common diseases...
November 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29124692/ultraviolet-radiations-skin-defense-damage-mechanism
#15
Dheeraj Mohania, Shikha Chandel, Parveen Kumar, Vivek Verma, Kumar Digvijay, Deepika Tripathi, Khushboo Choudhury, Sandeep Kumar Mitten, Dilip Shah
UV-radiations are the invisible part of light spectra having a wavelength between visible rays and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320-400 nm), UV-B (280-320 nm) and UV-C (200-280 nm). Ultraviolet rays can have both harmful and beneficial effects. UV-C has the property of ionization thus acting as a strong mutagen, which can cause immune-mediated disease and cancer in adverse cases. Numbers of genetic factors have been identified in human involved in inducing skin cancer from UV-radiations...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29082005/maternal-and-child-health-services-and-an-integrated-life-cycle-approach-to-the-prevention-of-non-communicable-diseases
#16
REVIEW
Luisa Brumana, Alvaro Arroyo, Nina R Schwalbe, Susanna Lehtimaki, David B Hipgrave
Described as the 'invisible epidemic', non-communicable diseases (NCDs) are the world's leading cause of death. Most are caused by preventable factors, including poor diet, tobacco use, harmful use of alcohol and physical inactivity. Diabetes, cancer and cardiovascular and chronic lung diseases were responsible for 38 million (68%) of global deaths in 2012. Since 1990, proportionate NCD mortality has increased substantially as populations have aged and communicable diseases decline. The majority of NCD deaths, especially premature NCD deaths (<70 years, 82%), occur in low-income and middle-income countries, and among poor communities within them...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29038298/subversion-of-nk-cell-and-tnf%C3%AE-immune-surveillance-drives-tumor-recurrence
#17
Tim Kottke, Laura Evgin, Kevin G Shim, Diana Rommelfanger, Nicolas Boisgerault, Shane Zaidi, Rosa Maria Diaz, Jill Thompson, Elizabeth Ilett, Matt Coffey, Peter Selby, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard Vile
Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment-resistant, immune-invisible recurrences has major clinical significance. We show here that this transition is mediated through the subversion of two key elements of innate immunosurveillance. In the first, the role of TNFα changes from an antitumor effector against primary tumors into a growth promoter for MRD. Second, whereas primary tumors induced a natural killer (NK)-mediated cytokine response characterized by low IL6 and elevated IFNγ, PD-L1(hi) MRD cells promoted the secretion of IL6 but minimal IFNγ, inhibiting both NK-cell and T-cell surveillance...
October 15, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29030241/discovery-of-hidden-allosteric-sites-as-novel-targets-for-allosteric-drug-design
#18
REVIEW
Shaoyong Lu, Mingfei Ji, Duan Ni, Jian Zhang
Hidden allosteric sites, as a novel type of allosteric site, are invisible in ligand-unbound (apo) crystal structures, but can emerge in ligand-bound (holo) crystal structures when a specific ligand binds to, and stabilizes, a unique conformation favored by the ligand. However, the identification of these sites is a significant challenge. Several computational and experimental approaches have been developed to identify such sites in proteins. Here, we outline these approaches, with a focus on examples of the successful use of such techniques...
October 10, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28950835/determinants-of-uptake-of-hepatitis-b-testing-and-healthcare-access-by-migrant-chinese-in-the-england-a-qualitative-study
#19
Andrew Chee Keng Lee, Alicia Vedio, Eva Zhi Hong Liu, Jason Horsley, Amrita Jesurasa, Sarah Salway
BACKGROUND: Global migration from hepatitis B endemic countries poses a significant public health challenge in receiving low-prevalence countries. In the UK, Chinese migrants are a high risk group for hepatitis B. However, they are an underserved population that infrequently accesses healthcare. This study sought to increase understanding of the determinants of hepatitis B testing and healthcare access among migrants of Chinese ethnicity living in England. METHODS: We sought to obtain and integrate insights from different key stakeholders in the system...
September 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28934765/qualitative-study-the-experience-and-impact-of-living-with-behcet-s-syndrome
#20
Vicky Tai, Karen Lindsay, Joanne L Sims, Fiona M McQueen
AIM: Behcet's syndrome is a rare chronic multisystemic vasculitis of unknown aetiology, is unpredictable and can cause life-threatening complications. This qualitative study aims to explore the experiences of patients living with Behcet's syndrome in New Zealand. METHODS: Eight English-speaking patients participated in in-depth semi-structured interviews about their experiences of living with Behcet's syndrome. Interviews were recorded and transcribed. Data were analysed using a general inductive thematic approach...
September 22, 2017: New Zealand Medical Journal
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