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Invisible disease

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https://www.readbyqxmd.com/read/28102557/cardiovascular-disease-and-prediabetes-as-complex-illness-people-s-perspectives
#1
Kim van Wissen, Michelle Thunders, Karen Mcbride-Henry, Margaret Ward, Jeremy Krebs, Rachel Page
Cardiovascular disease (CVD) and sustained high blood glucose as prediabetes are an established comorbidity. People's experience in reconciling these long-term conditions requires deeper appreciation if nurses are to more effectively support person-centred care for people who have them. Our analysis explores the initial experience of people admitted to hospital with CVD who then find they also have sustained high blood glucose. Our methodology is informed by the philosophy of Gadamer and applies interpretive description to develop an interpretation of participant experiences...
January 19, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28050720/indocyanine-green-visualization-of-middle-meningeal-artery-before-craniotomy-during-surgical-revascularization-for-moyamoya-disease
#2
Nozomu Tanabe, Shusuke Yamamoto, Daina Kashiwazaki, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda
BACKGROUND: The middle meningeal artery (MMA) is well known to function as an important collateral channel to the territory of the anterior cerebral artery in moyamoya disease. This study was aimed to evaluate whether indocyanine green (ICG) videoangiography could visualize the anterior branch of the MMA before craniotomy during surgical revascularization for moyamoya disease. METHODS: This study included 19 patients who developed TIA, ischemic stroke or hemorrhagic stroke due to moyamoya disease...
January 3, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28050271/evolution-of-tumor-clones-in-adult-acute-lymphoblastic-leukemia
#3
S Yu Smirnova, Yu V Sidorova, N V Ryzhikova, K A Sychevskaya, E N Parovichnikova, A B Sudarikov
Clonal instability of a tumor cell population in acute lymphoblastic leukemia (ALL) may complicate the monitoring of a minimal residual disease (MRD) by means of patient-specific targets identified at the disease onset. Most of the data concerning the possible instability of rearranged clonal TCR and IG genes during disease recurrence were obtained for ALL in children. The appropriate features of adult ALL, which are known to differ from those of childhood ALL in certain biological characteristics and prognosis, remain insufficiently studied...
October 2016: Acta Naturae
https://www.readbyqxmd.com/read/28045236/usefulness-of-a-ct-guided-hookwire-marking-in-laparoscopic-partial-hepatectomy-for-hepatocellular-carcinoma-invisible-on-ultrasonography
#4
Kazuteru Monden, Hiroshi Sadamori, Masayoshi Hioki, Kanyu Nakano, Shinya Asami, Satoshi Ohno, Kyo Sasaki, Toru Ueki, Kazuhisa Yabushita, Mayu Uka, Tsuyoshi Hyodo, Kousaku Sakaguchi, Norihisa Takakura
INTRODUCTION: The intra-operative detection of hepatocellular carcinoma (HCC) by ultrasonography is indispensable for laparoscopic partial hepatectomy. However, it is occasionally difficult to localize an HCC on an ultrasound in chronic liver disease. Two cases of partial hepatectomy using hookwire marking under CT guidance are presented. MATERIALS AND SURGICAL TECHNIQUE: The location of the HCC was identified by CT scan, and the puncture site was determined. A hookwire system, made of a stainless steel hook, was used to localize the HCC...
February 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28025106/effect-of-lysosomotropic-molecules-on-cellular-homeostasis
#5
REVIEW
Omer F Kuzu, Mesut Toprak, M Anwar Noory, Gavin P Robertson
Weak bases that readily penetrate through the lipid bilayer and accumulate inside the acidic organelles are known as lysosomotropic molecules. Many lysosomotropic compounds exhibit therapeutic activity and are commonly used as antidepressant, antipsychotic, antihistamine, or antimalarial agents. Interestingly, studies also have shown increased sensitivity of cancer cells to certain lysosomotropic agents and suggested their mechanism of action as a promising approach for selective destruction of cancer cells...
December 23, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28001035/serotonin-in-space-understanding-single-fibers
#6
Skirmantas Janušonis
All brain regions contain fibers that store and release 5-hydroxytryptamine (5-HT, serotonin). Since these fibers often do not have well-defined trajectories, most studies have focused on their overall densities, a measure that can be associated with local 5-HT tone in heathy and diseased brains. However, the observed fiber densities are the consequence of the behavior of single fibers. Evidence is presented as to why understanding single-fiber trajectories is important for basic and clinical neuroscience. In particular, serotonergic fibers can be viewed as natural, readily detectable stochastic probes that sample the invisible microarchitecture of brain tissue...
December 21, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27993688/improving-access-to-tuberculosis-preventive-therapy-and-treatment-for-children
#7
REVIEW
Ben J Marais
Children suffer a huge burden of disease in tuberculosis (TB) endemic countries. This disease burden was largely invisible when TB control programmes focused exclusively on adults with sputum smear-positive disease. High-level advocacy and better data have improved visibility, but the establishment of functional paediatric TB programmes remains challenging. The key issues that limit children's access to TB preventive therapy and treatment in endemic areas are briefly discussed. Barriers to preventive therapy include (1) the perceived inability to rule out active disease, (2) fear of creating drug resistance, (3) non-implementation of existing guidelines in the absence of adequate monitoring, and (4) poor adherence with long preventive therapy courses...
December 16, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27989557/the-invisible-child-childhood-heart-disease-in-global-health
#8
Bistra Zheleva, J Brian Atwood
No abstract text is available yet for this article.
December 15, 2016: Lancet
https://www.readbyqxmd.com/read/27951611/clinical-implications-of-low-grade-dysplasia-found-during-inflammatory-bowel-disease-surveillance-a-retrospective-study-comparing-chromoendoscopy-and-white-light-endoscopy
#9
Joren R Ten Hove, Erik Mooiweer, Andrea E van der Meulen de Jong, Evelien Dekker, Cyriel Y Ponsioen, Peter D Siersema, Bas Oldenburg
Background and study aims: Current guidelines recommend the use of pancolonic chromoendoscopy for surveillance of patients with inflammatory bowel disease (IBD). It is currently unknown whether low grade dysplasia (LGD) found using chromoendoscopy carries a similar risk of high grade dysplasia (HGD) or colorectal cancer (CRC) compared with LGD detected using white-light endoscopy (WLE). The aim of this study was to compare the risk of advanced neoplasia, a combined endpoint of HGD and CRC, during follow-up after detection of lesions containing LGD identified with either chromoendoscopy or WLE...
December 12, 2016: Endoscopy
https://www.readbyqxmd.com/read/27788645/educating-people-with-chronic-obstructive-pulmonary-disease
#10
(no author information available yet)
In this study, researchers explored the experiences of 14 people with chronic obstructive pulmonary disease. The three main themes of the findings are being trapped in an invisible cage, torments in the winter and striving for wellness.
October 28, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27776544/anti-n-methyl-d-aspartate-receptor-encephalitis-with-an-imaging-invisible-ovarian-teratoma-a-case-report
#11
Zainab M Abdul-Rahman, Peter K Panegyres, Margareta Roeck, David Hawkins, Jude Bharath, Paul Grolman, Cliffe Neppe, David Palmer
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis is a recently discovered disease entity of paraneoplastic limbic encephalitis. It largely affects young women and is often associated with an ovarian teratoma. It is a serious yet treatable condition if diagnosed early. Its remedy involves immunotherapy and surgical removal of the teratoma of the ovaries. This case of anti-N-methyl-D-aspartate receptor encephalitis involves an early surgical intervention with bilateral oophorectomy, despite negative imaging evidence of a teratoma...
October 24, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27759865/portable-optical-coherence-tomography-detection-or-confirmation-of-ophthalmoscopically-invisible-or-indeterminate-active-retinoblastoma
#12
Michael I Seider, Dilraj S Grewal, Prithvi Mruthyunjaya
Portable, hand-held optical coherence tomography (OCT) revealed three clinically relevant yet not ophthalmoscopically detected or confirmed manifestations of retinoblastoma in a single patient with familial bilateral disease. Specifically, OCT showed new retinal tumors, new vitreous seeds, and tumor recurrence before they could be detected or confirmed by ophthalmoscopy. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:965-968.].
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27739032/a-qualitative-systematic-review-of-patients-experience-of-osteoporosis-using-meta-ethnography
#13
K L Barker, F Toye, C J Minns Lowe
: We aimed to systematically review qualitative studies exploring the experience of living with osteoporosis to develop new conceptual understanding. We identified themes about the invisibility/visibility of osteoporosis, the experience of uncertainty of living with osteoporosis (OP) and living with an ageing body and the place of gender. PURPOSE: The aim of this review was to systematically review the body of qualitative studies exploring the experience of living with either osteoporosis or osteopenia and to use meta-ethnography to develop new conceptual understanding...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27726004/deconstructing-the-chlamydial-cell-wall
#14
Anna Klöckner, Henrike Bühl, Patrick Viollier, Beate Henrichfreise
The evolutionary separated Gram-negative Chlamydiales show a biphasic life cycle and replicate exclusively within eukaryotic host cells. Members of the genus Chlamydia are responsible for many acute and chronic diseases in humans, and Chlamydia-related bacteria are emerging pathogens. We revisit past efforts to detect cell wall material in Chlamydia and Chlamydia-related bacteria in the context of recent breakthroughs in elucidating the underlying cellular and molecular mechanisms of the chlamydial cell wall biosynthesis...
September 21, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27719695/a-translation-of-the-linnaean-dissertation-the-invisible-world
#15
Janis Antonovics, Jacobus Kritzinger
This study presents the first translation from Latin to English of the Linnaean dissertation Mundus invisibilis or The Invisible World, submitted by Johannes Roos in 1769. The dissertation highlights Linnaeus's conviction that infectious diseases could be transmitted by living organisms, too small to be seen. Biographies of Linnaeus often fail to mention that Linnaeus was correct in ascribing the cause of diseases such as measles, smallpox and syphilis to living organisms. The dissertation itself reviews the work of many microscopists, especially on zoophytes and insects, marvelling at the many unexpected discoveries...
September 2016: British Journal for the History of Science
https://www.readbyqxmd.com/read/27698620/the-hoops-hopes-and-hypes-of-human-microbiome-research
#16
Elisabeth M Bik
Recent developments in sequencing methods and bioinformatics analysis tools have greatly enabled the culture-independent analysis of complex microbial communities associated with environmental samples, plants, and animals. This has led to a spectacular increase in the number of studies on both membership and functionalities of these hitherto invisible worlds, in particular those of the human microbiome. The wide variety in available microbiome tools and platforms can be overwhelming, and making sound conclusions from scientific research can be challenging...
September 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/27660119/2016-presidential-address-diabetes-at-212%C3%A2-confronting-the-invisible-disease
#17
Desmond Schatz
This address was delivered by Desmond Schatz, MD, President, Medicine & Science, of the American Diabetes Association (ADA), at the Association's 76th Scientific Sessions in New Orleans, LA, on 12 June 2016. Dr. Schatz is Professor and Associate Chairman of Pediatrics, Medical Director of the University of Florida Diabetes Institute, and Director of the Clinical Research Center at the University of Florida, Gainesville, FL. A physician-scientist, he has been involved in type 1 diabetes research since the mid-1980s and has published over 300 articles and book chapters...
October 2016: Diabetes Care
https://www.readbyqxmd.com/read/27617094/reduction-of-fluoroscopy-time-and-radiation-dosage-during-catheter-ablation-for-atrial-fibrillation
#18
Kenichiro Yamagata, Bashar Aldhoon, Josef Kautzner
Radiofrequency catheter ablation has become the treatment of choice for atrial fibrillation (AF) that does not respond to antiarrhythmic drug therapy. During the procedure, fluoroscopy imaging is still considered essential to visualise catheters in real-time. However, radiation is often ignored by physicians since it is invisible and the long-term risks are underestimated. In this respect, it must be emphasised that radiation exposure has various potentially harmful effects, such as acute skin injury, malignancies and genetic disease, both to patients and physicians...
August 2016: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/27609647/impaired-perception-of-human-movements-in-parkinson-s-disease
#19
Silvie Kloeters, Christian J Hartmann, Viktoria D Pundmann, Alfons Schnitzler, Martin Südmeyer, Joachim Lange
Interacting with other individuals in a social world requires fast and accurate perception of other individuals' identity, actions, or intentions. Humans are very efficient in these social tasks, as they can extract social information even if the actor is represented only by a handful of point-lights on an otherwise invisible body. Theories have argued that efficient visual perception of actions is based on intact motor system functioning. The motor system provides visuo-motor action representations shaped by the observer's own movements or motor repertoire...
September 5, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27582434/missing-the-mark-prostate-cancer-upgrading-by-systematic-biopsy-over-magnetic-resonance-imaging-transrectal-ultrasound-fusion-biopsy
#20
Akhil Muthigi, Arvin K George, Abhinav Sidana, Michael Kongnyuy, Richard Simon, Vanessa Moreno, Maria J Merino, Peter L Choyke, Baris Turkbey, Bradford J Wood, Peter A Pinto
PURPOSE: Multiparametric magnetic resonance imaging and fusion biopsy detect more high risk prostate cancer and less low risk prostate cancer than systematic biopsy. However, there remains a small subset of patients in whom systematic biopsy captures higher grade disease than fusion biopsy. We sought to identify potential mechanisms of the failure of fusion biopsy in the detection of clinically significant prostate cancer. MATERIALS AND METHODS: We reviewed a prospectively maintained database of patients who underwent multiparametric magnetic resonance imaging followed by fusion biopsy and systematic biopsy from 2007 to 2014...
February 2017: Journal of Urology
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