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https://www.readbyqxmd.com/read/28619043/effect-of-transcutaneous-electrical-stimulation-treatment-on-lower-urinary-tract-symptoms-after-class-iii-radical-hysterectomy-in-cervical-cancer-patients-study-protocol-for-a-multicentre-randomized-controlled-trial
#1
Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-Ting Cao, Xin Yang, Jing-Song Han, Yang-Feng Wu, Kathleen H Reilly, Jian-Liu Wang
BACKGROUND: Class III radical hysterectomy (RH III)_plus pelvic lymphadenectomy is the standard surgery for early stage cervical cancer (CC) patients, the 5 year survival rate is about 90%, but pelvic floor disorders especially bladder dysfunction are common due to damaged vessels and nerve fibers following surgery. Transcutaneous electrical stimulation (TENS) treatment has been used to treat bladder disorders for many years, but its effect on cervical cancer patients, the best treatment time point and stimulated protocol, had never been assessed...
June 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28608328/towards-accurate-and-precise-t-1-and-extracellular-volume-mapping-in-the-myocardium-a-guide-to-current-pitfalls-and-their-solutions
#2
REVIEW
Donnie Cameron, Vassilios S Vassiliou, David M Higgins, Peter D Gatehouse
Mapping of the longitudinal relaxation time (T 1) and extracellular volume (ECV) offers a means of identifying pathological changes in myocardial tissue, including diffuse changes that may be invisible to existing T 1-weighted methods. This technique has recently shown strong clinical utility for pathologies such as Anderson-Fabry disease and amyloidosis and has generated clinical interest as a possible means of detecting small changes in diffuse fibrosis; however, scatter in T 1 and ECV estimates offers challenges for detecting these changes, and bias limits comparisons between sites and vendors...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28605444/is-elimination-of-hepatitis-c-from-the-uk-by-2030-a-realistic-goal
#3
Will Gelson, Graeme Alexander
Introduction: Highly effective, combination therapy for chronic hepatitis C virus (HCV) infection is now available. Current cure rates are close to 100% and applicable to all patients irrespective of race, age, severity of liver disease or viral genotype. Remarkably for persistent infection, current treatment is recommended for as little as 12 weeks; recent studies suggest even shorter courses. In contrast to interferon-based therapy, present regimens have few side effects and serious adverse events are rare...
June 9, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28604289/a-suitable-soil-plague-s-urban-breeding-grounds-at-the-dawn-of-the-third-pandemic
#4
Christos Lynteris
A pressing question during the first half-decade of the third plague pandemic (1894-9) was what was a 'suitable soil' for the disease. The question related to plague's perceived ability to disappear from a given city only to reappear at some future point; a phenomenon that became central to scientific investigations of the disease. However, rather than this simply having a metaphorical meaning, the debate around plague's 'suitable soil' actually concerned the material reality of the soil itself. The prevalence of plague in the working-class neighbourhood of Taipingshan during the first major outbreak of the pandemic, in 1894 in Hong Kong, led to an extensive debate regarding the ability of the soil to harbour and even spread the disease...
July 2017: Medical History
https://www.readbyqxmd.com/read/28559085/clinically-focused-molecular-investigation-of-1000-consecutive-families-with-inherited-retinal-disease
#5
Edwin M Stone, Jeaneen L Andorf, S Scott Whitmore, Adam P DeLuca, Joseph C Giacalone, Luan M Streb, Terry A Braun, Robert F Mullins, Todd E Scheetz, Val C Sheffield, Budd A Tucker
PURPOSE: To devise a comprehensive multiplatform genetic testing strategy for inherited retinal disease and to describe its performance in 1000 consecutive families seen by a single clinician. DESIGN: Retrospective series. PARTICIPANTS: One thousand consecutive families seen by a single clinician. METHODS: The clinical records of all patients seen by a single retina specialist between January 2010 and June 2016 were reviewed, and all patients who met the clinical criteria for a diagnosis of inherited retinal disease were included in the study...
May 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28501996/application-of-hydrogel-nanoparticles-for-the-capture-concentration-and-preservation-of-low-abundance-biomarkers
#6
Ruben Magni, Alessandra Luchini
In the recent years, a lot of emphasis has been placed on the discovery and detection of clinically relevant biomarkers. Biomarkers are crucial for the early detection of several diseases, and they play an important role in the improvement of current treatments, thus reducing patient mortality rate. Because biofluids account to 60% of the body mass, they represent a goldmine of significant biomarkers. Unfortunately, because of their low concentration in body fluids, their lability, and the presence of high abundance proteins (i...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28488844/mri-in-prostate-cancer-detection-and-management-a-systematic-review
#7
Fabio Monni, Paolo Fontanella, Angelica Grasso, Peter Wiklund, Yen-Chuan Ou, Marco Randazzo, Bernardo Rocco, Emanuele Montanari, Giampaolo Bianchi
INTRODUCTION: The aim of our work was to evaluate the role of multi-parametric MRI (mpMRI) in detection and management of prostate cancer (PC); specifically investigating the efficacy of mpMRI-based biopsy techniques in terms of diagnostic yield of significant prostate neoplasm and the improved management of patient who choose conservative treatments or active surveillance. EVIDENCE ACQUISITION: A systematic and critical analysis through Medline, Embase, Scopus and Web of Science databases was carried out in March 2016, following the PRISMA ("Preferred Reporting Items for Systematic Reviews and Meta-Analyses") statement...
May 8, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28459041/advancing-cancer-therapy-with-present-and-emerging-immuno-oncology-approaches
#8
REVIEW
Jeff Kamta, Maher Chaar, Anusha Ande, Deborah A Altomare, Sihem Ait-Oudhia
Immuno-oncology (I-O) is a young and growing field on the frontier of cancer therapy. Contrary to cancer therapies that directly target malignant cells, I-O therapies stimulate the body's immune system to target and attack the tumor, which is otherwise invisible to, or inhibiting the immune response. To this end, several methods have been developed: First, passive therapies that enable T-cells to fight the tumor without direct manipulation, typically through binding and modifying the intracellular signaling of surface receptors...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28453059/-public-health-in-the-health-disease-continuum-an-analysis-from-a-professional-perspective
#9
Valeria Santoro-Lamelas
Objective To explore the components that health professionals use to build and define the concept of Public Health as a specific area of knowledge and intervention within public health policies. Method A qualitative analysis of content was performed based on 20 semi-structured interviews with health professionals participating in the demonstration project conducted by the Public Health Agency of Garrotxa in Catalonia, Spain (2009-2012). Results Health professionals use the health-disease continuum to provide guidance to all State policies on health: public health is usually related to health and care regarding disease...
August 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28441067/anterior-segment-optical-coherence-tomography-angiography-for-identification-of-iris-vasculature-and-staging-of-iris-neovascularization-a-pilot-study
#10
Philipp K Roberts, Debra A Goldstein, Amani A Fawzi
Purpose/Aim of the study: To assess the ability of optical coherence tomographic angiography (OCTA) to visualize the normal iris vasculature as well as neovascularization of the iris (NVI). MATERIALS AND METHODS: Study participants with healthy eyes, patients at risk of NVI development and patients with active or regressed NVI were consecutively included in this cross-sectional observational study. Imaging was performed using a commercially available OCTA system (RTVue- XR Avanti, Optovue Inc...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28333581/the-social-construction-of-fibromyalgia-as-a-health-problem-from-the-perspective-of-policies-professionals-and-patients
#11
Erica Briones-Vozmediano
BACKGROUND: Fibromyalgia is a painful chronic disease, suffered mainly by women, that consolidates a number of symptoms and skeletal muscle issues which are little understood. OBJECTIVES: To explore the social construction of FM from the perspective of health policies, patients, and health professionals involved in their medical attention. METHODS: I) Policy review of national and regional health plans in a national and international context, the clinical protocols for fibromyalgia in Spain, and the Parliamentary initials in the European and Spanish context; and ii) Qualitative study involving 28 personal interviews with 16 fibromyalgia patients and 12 interviews with health care professionals in Spain...
2017: Global Health Action
https://www.readbyqxmd.com/read/28302650/erratum-2016-presidential-address-diabetes-at-212%C3%A2-confronting-the-invisible-disease-diabetes-care-2016-39-1657-1663
#12
Desmond Schatz
No abstract text is available yet for this article.
May 2017: Diabetes Care
https://www.readbyqxmd.com/read/28289480/ultrasound-elastography-for-determination-of-the-age-of-venous-thrombi-evaluation-of-thrombus-evolution-in-patients-after-sclerotherapy
#13
Łukasz Paluch, Ewa Nawrocka-Laskus, Agnieszka Dąbrowska, Tadeusz Popiela, Jerzy Walecki
BACKGROUND: Venous thrombosis is a multicausal disease involving intravenous clot formation. It may occur spontaneously or after provoking events, such as traumatic injuries to the pelvis, upper and lower extermities, immobilization, intravascular procedures, including venous catheterization or injection. Color Doppler ultrasonography is a rapid and non-invasive technique for evaluation of venous disease. It is a very sensitive method for detection of thrombi, but has some limitations, e...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28276544/advanced-optoacoustic-methods-for-multiscale-imaging-of-in-vivo-dynamics
#14
REVIEW
X L Deán-Ben, S Gottschalk, B Mc Larney, S Shoham, D Razansky
Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems...
April 18, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28210315/news
#15
REVIEW
(no author information available yet)
Rare diseases are defined by a limited prevalence of ≤5 cases per 10 000 individuals in Europe [1]. This definition includes around 8000 diseases, many of which are unknown not only to the public but also to the vast majority of healthcare professionals and text books. It is estimated that, as a whole, rare diseases affect around 25 to 30 million people in Europe. Most rare diseases are chronic and debilitating and appear in early childhood or young adulthood, accounting for a significant proportion of infant mortality and childhood/life-long disability...
December 2016: Breathe
https://www.readbyqxmd.com/read/28176657/emerging-methods-for-structural-analysis-of-protein-aggregation
#16
Eshan Khan, Amit Kumar
Protein misfolding and aggregation is a key attribute of different neurodegenerative diseases. Misfolded and aggregated proteins are intrinsically disordered and rule out structure based drug design. The comprehensive characterization of misfolded proteins and associated aggregation pathway is prerequisite to develop therapeutics for neurodegenerative diseases caused due to the protein aggregation. Visible protein aggregates used to be the final stage during aggregation mechanism. The structural analysis of intermediate steps in such protein aggregates will help us to discern the conformational role and subsequently involved pathways...
February 6, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28153937/beliefs-and-attitudes-to-bowel-cancer-screening-in-patients-with-ckd-a-semistructured-interview-study
#17
Laura J James, Germaine Wong, Jonathan C Craig, Angela Ju, Narelle Williams, Wai H Lim, Nicholas Cross, Allison Tong
BACKGROUND AND OBJECTIVES: Bowel cancer is a leading cause of cancer-related death in people with CKD. Shared decision making regarding cancer screening is particularly complex in CKD and requires an understanding of patients' values and priorities, which remain largely unknown. Our study aimed to describe the beliefs and attitudes to bowel cancer screening in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Face to face, semistructured interviews were conducted from April of 2014 to December of 2015 with 38 participants ages 39-78 years old with CKD stages 3-5, on dialysis, or transplant recipients from four renal units in Australia and New Zealand...
April 3, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28129486/-it-s-not-me-it-s-not-really-me-insights-from-patients-on-living-with-systemic-sclerosis-an-interview-study
#18
Daniel Sumpton, Vivek Thakkar, Sean O'Neill, Davinder Singh-Grewal, Jonathan C Craig, Allison Tong
OBJECTIVES: Patients with systemic sclerosis suffer severe physical limitations and psychological morbidity but their lived experience remains underrepresented and is reflected in the scarcity of evidence based patient-centered interventions. We aimed to describe patients' perspectives of systemic sclerosis to inform strategies to improve their care. METHODS: Face-to-face semi-structured interviews were conducted with 30 adult patients with limited or diffuse systemic sclerosis in Australia...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28128905/open-partial-nephrectomy-for-entirely-intraparenchymal-tumors-a-matched-case-control-study-of-oncologic-outcome-and-complication-rate
#19
Piotr Zapala, Bartosz Dybowski, Nina Miazek, Piotr Radziszewski
PURPOSE: To compare the oncologic and clinical outcomes for open partial nephrectomy (OPN) performed in patients with entirely intraparenchymal tumors versus casematched controls, with exophytic lesions. MATERIAL AND METHODS: Patients having undergone OPN between 2007 and 2012 were investigated. Exclusion criteria included patients with a benign tumor, advanced malignancy, malignancies other than renal cell carcinoma, end-stage renal failure, or 3 or more co-existing chronic diseases...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28128787/an-invisible-student-population-accommodating-and-serving-college-students-with-lupus
#20
Neelam Agarwal, Vinod Kumar
BACKGROUND: Systemic Lupus Erythematosus (SLE), or lupus, is a chronic autoimmune disorder. Individuals with lupus face unique psychosocial and emotional challenges such as living with the unpredictability of the disease, symptoms such as fatigue, pain and depression, anxiety, cognitive problems, and coping with stress. OBJECTIVE: This article attempts to shed light on the role that lupus plays in the lives of college students in their academics and other unique psychosocial needs...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
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