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Hashimoto's thyroidism

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https://www.readbyqxmd.com/read/29788738/hashimoto-s-thyroiditis-nodular-goiter-or-follicular-adenoma-combined-with-papillary-thyroid-carcinoma-play-protective-role-in-patients
#1
H Ma, L Li, K Li, T Wang, Y Zhang, C Zhang, Y Xu, X Wu, J Yu, H Wang, B Xiang, R Zhang, W Wang
Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto's thyroiditis(HT), nodular goiter(NG), Follicular adenoma(FA) and other types. However, the function of these diseases in PTC tumorigenesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Clinicopathological characteristics and BRAFV600E mutation status were compared between PTC and PTC+...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29787820/clinicopathological-characteristics-of-thyroid-transcription-factor-1-negative-small-cell-lung-cancers
#2
Yuko Iida, Shinobu Masuda, Yoko Nakanishi, Tetsuo Shimizu, Haruna Nishimaki, Mai Takahashi, Mari Hikichi, Shuichiro Maruoka, Yasuhiro Gon, Noriaki Takahashi, Shu Hashimoto
Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer (NSCLC); however, clinicopathological features of TTF-1-negative SCLC remain unclear. This study aimed to elucidate the characteristics of TTF-1-negative SCLC. We studied the associations between the expression of TTF-1 and the clinicopathological factors associated with SCLC, including survival and expression of neuroendocrine markers (synaptophysin, chromogranin A, and CD56), neuroendocrine cell-specific transcription factors (achaete-scute homolog like 1 (ASCL1), BRN2), a proliferation marker (Ki-67 labeling index), and an oncogene (Nuclear Factor 1B (NF1B))...
May 19, 2018: Human Pathology
https://www.readbyqxmd.com/read/29781213/thyroid-microcalcifications-in-the-absence-of-identifiable-nodules-and-their-association-with-thyroid-cancer
#3
Carolina Whittle, Marisol García, Eleonora Horvath, Jeannie Slater, Carmen Carrasco
OBJECTIVES: To determine ultrasound (US) and clinical findings of thyroid microcalcifications in the absence of a nodule and their association with the risk of malignancy. METHODS: The Institutional Review Board approved a 5-year retrospective study. Twenty-one patients with clustered or scattered thyroid microcalcifications in the absence of nodules on US images who underwent fine-needle aspiration biopsies (FNABs) were included. Demographic and clinical data, US findings, and pathologic results were registered...
May 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29778090/massive-pericardial-effusion-without-cardiac-tamponade-due-to-subclinical-hypothyroidism-hashimoto-s-disease
#4
Panteleimon E Papakonstantinou, Nikolaos Gourniezakis, Christos Skiadas, Alexandros Patrianakos, Achilleas Gikas
CONTEXT: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Herein, the case of a 70-year-old woman with a massive pericardial effusion due to Hashimoto's disease is presented. ISSUES: A 70-year-old female from a rural village on the island of Crete, Greece, was admitted to our hospital due to a urinary tract infection...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29777516/irisin-levels-increase-after-treatment-in-patients-with-newly-diagnosed-hashimoto-thyroiditis
#5
Z A Uc, S Gorar, S Mizrak, S Gullu
PURPOSE: Irisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects. METHODS: The study included 26 patients with overt hypothyroidism due to Hashimoto thyroiditis and 19 healthy subjects...
May 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29777250/prevalence-of-temporomandibular-disorders-in-patients-with-hashimoto-thyroiditis
#6
Alina Grozdinska, Elisabeth Hofmann, Matthias Schmid, Ursula Hirschfelder
OBJECTIVES: Autoimmune thyroid disease (AITD), also known as Hashimoto thyroiditis (HT), is a degenerative inflammatory disease with high prevalence among women and has been associated with fibromyalgia and widespread chronic pain. The goal was to determine the frequency of temporomandibular disorders (TMD) in patients with HT. METHODS: In all, 119 women (age 19-60 years) were divided into a study (52 women diagnosed with HT) and a control (67 healthy individuals, of which 15 were excluded) group...
May 17, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/29774542/accelerated-pre-senile-systemic-amyloidosis-in-pacap-knockout-mice-a-protective-role-of-pacap-in-age-related-degenerative-processes
#7
Dora Reglodi, Adel Jungling, Rémi Longuespée, Joerg Kriegsmann, Rita Casadonte, Mark Kriegsmann, Tamas Juhasz, Sebastian Bardosi, Andrea Tamas, Balazs Daniel Fulop, Krisztina Kovacs, Zsuzsanna Nagy, Jason Sparks, Attila Miseta, Gabriel Mazzucchelli, Hitoshi Hashimoto, Attila Bardosi
Dysregulation of neuropeptides may play an important role in aging-induced impairments. Among them, pituitary adenylate cyclase activating polypeptide (PACAP) is a potent cytoprotective peptide that provides an endogenous control against a variety of tissue-damaging stimuli. We hypothesized that the progressive decline of PACAP throughout life, and the well-known general cytoprotective effects of PACAP lead to age-related pathophysiological changes in PACAP deficiency, supported by the increased vulnerability to various stressors of animals partially or totally lacking PACAP...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29772535/untangling-thyroid-autoimmunity-through-modeling-and-simulation
#8
Stephen J Merrill, Balamurugan Pandiyan
Thyroid autoimmunity is characterized by a large number of identified factors, and determining the relative importance of genetics and environment, for instance, can be difficult. In addition, the definition and progression of the individual diseases can also be challenging, and questions such as "when to begin treatment" or even "should treatment be begun" can be problematic. One approach to handling situations in which there are many factors is utilizing mathematical modeling. In a model, quantities that are clinically measurable are related through equations, based on known and inferred relationships between the systems involved...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29770856/risk-factors-associated-with-intrathyroid-extension-of-thyroid-microcarcinomas
#9
Nikola Slijepcevic, Vladan Zivaljevic, Aleksandar Diklic, Milan Jovanovic, Branislav Oluic, Ivan Paunovic
PURPOSE: The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it. METHODS: A retrospective study of 301 patients operated for benign thyroid diseases (hyperthyroid diseases, multinodular goitre, Hashimoto thyroiditis and benign thyroid tumours) was performed at a high-volume endocrine surgery unit of a tertiary referral academic hospital, in a 5-year period...
May 17, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29765436/anti-thyroid-antibodies-parietal-cell-antibodies-and-tissue-transglutaminase-antibodies-in-patients-with-autoimmune-thyroid-disease
#10
Orit Twito, Yonatan Shapiro, Aviva Golan-Cohen, Yoav Dickstein, Rosane Ness-Abramof, Menachem Shapiro
Introduction: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20-25%, and that of celiac antibodies is 2-5%. The goal of this study was to determine the prevalence of PC-Ab and anti-tissue transglutaminase antibodies (tTG-Ab) in patients with ATD and to evaluate the correlation between anti-thyroid antibodies and the other antibodies. Material and methods: The files of 120 Israeli Jews and Arabs with ATD were evaluated for anti-thyroglobulin antibodies (Tg-Ab), anti-thyroid peroxidase antibodies (TPO-Ab), PC-Ab and tTG-Ab...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764904/aberrant-mrp14-expression-in-thyroid-follicular-cells-mediates-chemokine-secretion
#11
Xuan Luo, Tingting Zheng, Chaoming Mao, Xin Dong, Xiao Mou, Chengcheng Xu, Qingyan Lu, Baocui Liu, Shengjun Wang, Yichuan Xiao
Myeloid-related protein 14 (MRP14) is responsible for inflammatory reactions. However, the correlation between MRP14 and Hashimoto's thyroiditis (HT) is still not clear. In this study, we examined the status of MRP14 in thyroid tissues and sera of HT patients and explored the mechanism of IL-1β-mediated regulation of MRP14 expression, as well as the effects of MRP14 on pro-inflammatory chemokine secretion in thyroid follicular cells (TFCs), to elucidate the role of MRP14 in HT development. Our results showed dramatically increased MRP14 expression in thyroid tissues and sera from HT patients...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29764793/evaluation-of-the-ovarian-reserve-in-adolescents-with-hashimoto-s-thyroiditis-using-serum-anti-m%C3%A3-llerian-hormone-levels
#12
Ezgi Özalp Akın, Zehra Aycan
OBJECTIVE: This study aims to evaluate the ovarian reserve of the adolescent girls with Hashimoto's thyroiditis (HT) with serum anti-müllerian hormone (AMH) levels and compare to healthy adolescents. It is hypothesized that HT decreases ovarian reserve and AMH levels are lower in the HT group. METHOD: Thirty HT patients aged between 10-18 years and 30 healthy girls as the control group are enrolled in this cross-sectional study. The mean serum AMH levels of the groups are compared using the Mann-Whitney U test...
May 16, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29760568/co-existence-of-braf-v600e-and-tert-promoter-mutations-in-papillary-thyroid-carcinoma-is-associated-with-tumor-aggressiveness-but-not-with-lymph-node-metastasis
#13
Haoyu Ren, Yifan Shen, Daixing Hu, Wei He, Jing Zhou, Yijia Cao, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Yuhong Zhang, Xinliang Su
Background: Mutations of BRAF V600E and TERT promoters are associated with thyroid cancer development. This study further investigated association of these mutations with clinicopathological characteristics from patients with papillary thyroid carcinoma (PTC). Methods: Tumor tissues from 342 PTC patients were obtained for DNA extraction and polymerase chain reaction amplification to detect the BRAF V600E mutation using amplification-refractory mutation system-polymerase chain reaction...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29749329/is-celiac-disease-misdiagnosed-in-children-with-functional-constipation
#14
Sezin Akman, Özlem Şahaloğlu, Ceyhun Dalkan, Nerin Nadir Bahçeciler, Çiğdem Arıkan
BACKGROUND/AIMS: Functional constipation is one of the common problems in childhood, and it comprises approximately 5% of the pediatric outpatient clinical applications. On the other hand, celiac disease (CD) is an immune enteropathy with the prevalence between 1/150 and 1/200. In addition to the classical symptoms of the disease such as diarrhea and weight loss, the incidence of atypical symptoms is increasing. This study aims to determine the prevalence of CD in patients with chronic constipation...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29737268/evaluation-and-management-of-the-child-with-hypothyroidism
#15
Alexander A C Leung, Alexander K C Leung
BACKGROUND: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is therefore of utmost importance to optimize physical and neurodevelopmental outcomes. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of hypothyroidism in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "hypothyroidism"...
May 8, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29737056/-correlation-of-thyroid-autoantibodies-system-lupus-erythematosus-immunologic-indicators-and-disease-activity-in-sle-with-ht
#16
Huan Liu, Li-Hua Yang, Geng Yin, Qi-Bing Xie
OBJECTIVE: To investigate the correlation of disease activity and thyroid indicators ,immunologic markers of system lupus erythematosus (SLE) in SLE with Hashimoto's thyroiditis (HT). METHODS: The clinical data of 63 cases of SLE with HT were collected. According to Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000),we classified the patients into four groups,which were remission group (5 cases),low (19 cases),moderate (12 cases) and high (27 cases) disease activity group...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29730659/myxedema-coma-due-to-hashimoto-thyroiditis-a-rare-but-real-presentation-of-failure-to-thrive-in-infancy
#17
Ryan A Heksch, Rohan K Henry
BACKGROUND: Hashimoto thyroiditis (HT) is uncommon in infancy, and myxedema coma (MC) is even less common. While prior reports have documented these entities separately, to our knowledge, MC in combination with HT has not been reported before in this age group. METHODS/RESULTS: A 10-month-old female presented with ptosis, lethargy, dysphagia, and failure to thrive (FTT). She developed hypotension, bradycardia, hypothermia, and apnea requiring intubation. Initial thyroid-stimulating hormone was 422 μIU/mL, and free thyroxine was < 0...
May 4, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29726593/surgical-management-of-neck-pain-and-headache-associated-with-pediatric-hashimoto-s-thyroiditis
#18
Paul Krakovitz, Christine Cairns, Bahareh Michelle Schweiger, Brian Burkey
OBJECTIVES/HYPOTHESIS: Case reports of a painful variant of Hashimoto's thyroiditis exist in the literature; however, these cases have only been documented in adult patients and there are no standard treatment guidelines. The aim of this study was to describe an alternative management for Hashimoto's thyroiditis associated with medically intractable head and neck pain in the pediatric population. STUDY DESIGN: Case series with chart review. METHODS: The study was conducted in the Section of Pediatric Otolaryngology at the Cleveland Clinic...
May 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29720960/increased-requirement-of-replacement-doses-of-levothyroxine-caused-by-liver-cirrhosis
#19
Salvatore Benvenga, Giovanni Capodicasa, Sarah Perelli, Silvia Martina Ferrari, Poupak Fallahi, Alessandro Antonelli
Background: Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, and drinks cause L-T4 malabsorption, resulting in failure of serum TSH to be normal. Only rarely liver cirrhosis is mentioned as causing L-T4 malabsorption. Case report: In this study, we report increased requirement of daily doses of l-thyroxine in two patients with the atrophic variant of Hashimoto's thyroiditis and liver cirrhosis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29713105/progressive-non-familial-adult-onset-cerebellar-degeneration-an-unusual-occurrence-with-hashimoto-s-thyroiditis
#20
Raghavendra S Rao, Shubha Sheshadri, Dipanjan Bhattacharjee, Navin Patil, Karthik Rao
Progressive non-familial adult onset cerebellar degeneration has been rarely associated with hypothyroidism and is known to be reversible after therapy. We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels...
March 13, 2018: Psychopharmacology Bulletin
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