Wencheng Zhang, Eliane Wauthier, Giacomo Lanzoni, Homayoun Hani, Xianwen Yi, Diletta Overi, Lei Shi, Sean Simpson, Amanda Allen, Carolyn Suitt, Jennifer Ashley Ezzell, Domenico Alvaro, Vincenzo Cardinale, Eugenio Gaudio, Guido Carpino, Glenn Prestwich, Juan Dominguez-Bendala, David Gerber, Kyle Mathews, Jorge Piedrahita, Christopher Adin, Praveen Sethupathy, Zhiying He, Lola M Reid
Patch grafting, a novel strategy for transplantation of stem/progenitor organoids into porcine livers, has been found successful also for organoid transplantation into other normal or diseased solid organs in pigs and mice. Each organoid contained ∼100 cells comprised of biliary tree stem cells (BTSCs), co-hepato/pancreatic stem/progenitors, and partnered with early lineage stage mesenchymal cells (ELSMCs), angioblasts and precursors to endothelia and stellate cells. Patch grafting enabled transplantation into livers or pancreases of ≥108th (pigs) or ≥106th-7th (mice) organoids/patch...
August 7, 2022: Biomaterials