keyword
Keywords charlson comorbidity index, de...

charlson comorbidity index, delirium

https://read.qxmd.com/read/38321383/perioperative-point-of-care-testing-of-plasmacholinesterases-identifies-older-patients-at-risk-for-postoperative-delirium-an-observational-prospective-cohort-study
#1
JOURNAL ARTICLE
Matthias S Gruendel, Wibke Brenneisen, Jakob Wollborn, Gerrit Haaker, Melanie Meersch, Simone Gurlit, Ulrich Goebel
BACKGROUND: Postoperative delirium (POD) is a severe perioperative complication that may increase mortality and length-of-stay in older patients. Moreover, POD is a major economic burden to any healthcare system. An altered expression of Acetylcholine- and Butyrylcholinesterases (AChE, BuChE) due to an unbalanced neuroinflammatory response to trauma or an operative stimulus has been reported to play an essential role in the development of POD. We investigated if perioperative measurement of cholinesterases (ChEs) can help identifying patients at risk for the occurrence of POD in both, scheduled and emergency surgery patients...
February 6, 2024: BMC Geriatrics
https://read.qxmd.com/read/38252194/intraoperative-electroencephalogram-features-related-to-frailty-in-older-patients-an-exploratory-prospective-observational-study
#2
JOURNAL ARTICLE
Pan-Pan Fang, Hui-Wen Zhang, Xi-Xi Hao, Zi-Xiang Shang, Jun Li, Xue-Sheng Liu
Frailty is an independent risk factor for the increased incidence of postoperative delirium (POD). To date, the effect of frailty on intraoperative electroencephalogram (EEG) changes remains unexplored. The present study, an exploratory analysis of a prospective cohort study, aimed to investigate the differences in EEG characteristics between frail and robust patients. This prospective observational study was conducted between December 2020 and November 2021. The preoperative frailty status was assessed using the FRAIL scale...
January 22, 2024: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/38144372/optimal-postoperative-delirium-prediction-after-coronary-artery-bypass-grafting-surgery-a-prospective-cohort-study
#3
JOURNAL ARTICLE
Ying Ma, Dongxin Sui, Shaozhong Yang, Xiaomei Yang, Joseph Oldam, Jessica L Semel, Zhihao Wang, Ningning Fang
BACKGROUND: Postoperative delirium (POD) presents as a serious neuropsychiatric syndrome in patients undergoing off-pump coronary artery bypass grafting (OPCABG) surgery. This is correlated with higher mortality, cognitive decline, and increased costs. The Age-adjusted Charlson Comorbidity Index (ACCI) is recognized as an independent predictor for mortality and survival rate. The purpose of our study is to estimate the predictive value of the ACCI on the POD in patients undergoing OPCABG surgery...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38115237/can-we-let-our-patients-sleep-in-the-hospital-a-randomized-controlled-trial-of-a-pragmatic-sleep-protocol-in-surgical-oncology-patients
#4
JOURNAL ARTICLE
Kathrine Kelly, Hordur Kolbeinsson, Lauren M Blanck, Mariam Khan, Roxanne Kyriakakis, M Mura Assifi, G Paul Wright, Mathew Chung
BACKGROUND: Postoperative inpatients experience increased stress due to pain and poor restorative sleep than non-surgical inpatients. OBJECTIVES AND METHODS: A total of 101 patients, undergoing major oncologic surgery, were randomized to a postoperative sleep protocol (n = 50) or standard postoperative care (n = 51), between August 2020 and November 2021. The primary endpoint of the study was postoperative sleep time after major oncologic surgery...
March 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38061940/protect-the-neck-devastating-outcomes-of-cervical-spine-fractures-in-the-elderly
#5
JOURNAL ARTICLE
Jeremy Mormol, Laura Krech, Steffen Pounders, Chelsea Fisk, Alistair Chapman, Matthew Karek, Kailyn Kwong Hing
BACKGROUND: Cervical spine fractures are associated with high mortality in elderly patients. This study aims to identify patient-related and in-hospital factors contributing to this mortality. METHODS: A 3-year retrospective study of 235 patients aged 65+ presenting with cervical spine fractures was performed. Age cohorts were 65-74, 75-84, and 85+ years. Mortality was measured at 30, 90, 180 and 365-days post-discharge. RESULTS: Mortality was 11 ​%, 15 ​%, 19 ​%, and 22 ​% at 30-, 90-, 180- and 365-days respectively...
December 3, 2023: American Journal of Surgery
https://read.qxmd.com/read/38042511/risk-factors-and-associated-outcomes-of-postoperative-delirium-after-open-abdominal-aortic-aneurysm-repair
#6
JOURNAL ARTICLE
Richard D Gutierrez, Eric J T Smith, Zachary A Matthay, Warren J Gasper, Jade S Hiramoto, Michael S Conte, Emily Finlayson, Louise C Walter, James C Iannuzzi
OBJECTIVES: Open abdominal aortic aneurysm repair (OAR) is a major vascular procedure that incurs a large physiologic demand, increasing the risk for complications such as postoperative delirium (POD). We sought to characterize POD incidence, identify delirium risk factors, and evaluate the effect of delirium on postoperative outcomes. We hypothesized that POD following OAR would be associated with increased postoperative complications and resource utilization. METHODS: This was a retrospective study of all OAR cases from 2012-2020 at a single tertiary care center...
November 30, 2023: Journal of Vascular Surgery
https://read.qxmd.com/read/37964474/comparison-of-the-frailty-index-and-frailty-phenotype-and-their-associations-with-postoperative-delirium-incidence-and-severity
#7
JOURNAL ARTICLE
Stacie G Deiner, Edward R Marcantonio, Shrunjal Trivedi, Sharon K Inouye, Thomas G Travison, Eva M Schmitt, Tammy Hshieh, Tamara G Fong, Long H Ngo, Sarinnapha M Vasunilashorn
BACKGROUND: Recent studies have reported an association between presurgical frailty and postoperative delirium. However, it remains unclear whether the frailty-delirium relationship differs by measurement tool (e.g., frailty index vs. frailty phenotype) and whether frailty is associated with delirium, independent of preoperative cognition. METHODS: We used the successful aging after elective surgery (SAGES) study, a prospective cohort of older adults age ≥70 undergoing major non-cardiac surgery (N = 505)...
November 14, 2023: Journal of the American Geriatrics Society
https://read.qxmd.com/read/37955965/development-and-validation-of-a-prognostic-classification-model-predicting-postoperative-adverse-outcomes-in-older-surgical-patients-using-a-machine-learning-algorithm-retrospective-observational-network-study
#8
JOURNAL ARTICLE
Jung-Yeon Choi, Sooyoung Yoo, Wongeun Song, Seok Kim, Hyunyoung Baek, Jun Suh Lee, Yoo-Seok Yoon, Seonghae Yoon, Hae-Young Lee, Kwang-Il Kim
BACKGROUND: Older adults are at an increased risk of postoperative morbidity. Numerous risk stratification tools exist, but effort and manpower are required. OBJECTIVE: This study aimed to develop a predictive model of postoperative adverse outcomes in older patients following general surgery with an open-source, patient-level prediction from the Observational Health Data Sciences and Informatics for internal and external validation. METHODS: We used the Observational Medical Outcomes Partnership common data model and machine learning algorithms...
November 13, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/37865623/hyperactive-delirium-during-emergency-department-stay-analysis-of-risk-factors-and-association-with-short-term-outcomes
#9
JOURNAL ARTICLE
Òscar Miró, Gina Osorio, Aitor Alquézar-Arbé, Sira Aguiló, Cesáreo Fernández, Guillermo Burillo, Javier Jacob, Pere Llorens, Lluís Llauger, Ángel Peláez González, Edmundo Ramón Figuera Castro, Ricardo Juarez González, María José Blanco Hoffman, Fátima Fernandez Salgado, Teresa Pablos Pizarro, María Amparo Berenguer Díez, Marina Truyol Más, Nieves López-Laguna, Jacinto Garcia Acosta, Carmen Fernandez Domato, Francisco Javier Diego Robledo, Patxi Ezponda, Andrea Martinez Lorenzo, Juan Vicente Ortega Liarte, Inmaculada García Rupérez, Setefilla Borne Jerez, Claudia Corugedo Ovies, Blanca Andrea Gallardo Sánchez, Juan González Del Castillo
To investigate factors related to the development of hyperactive delirium in patients during emergency department (ED) stay and the association with short-term outcomes. A secondary analysis of the EDEN (Emergency Department and Elderly Needs) multipurpose multicenter cohort was performed. Patients older than 65 years arriving to the ED in a calm state and who developed confusion and/or psychomotor agitation requiring intravenous/intramuscular treatment during their stay in ED were assigned to delirium group...
October 21, 2023: Internal and Emergency Medicine
https://read.qxmd.com/read/37818480/resting-state-prefrontal-eeg-biomarker-in-correlation-with-postoperative-delirium-in-elderly-patients
#10
JOURNAL ARTICLE
Jeongmin Kim, Sujung Park, Keung-Nyun Kim, Yoon Ha, Sang-Jun Shin, Wonseok Cha, Ki-Young Lee, Jungmi Choi, Bon-Nyeo Koo
Postoperative delirium (POD) is associated with adverse outcomes in elderly patients after surgery. Electroencephalography (EEG) can be used to develop a potential biomarker for degenerative cerebral dysfunctions, including mild cognitive impairment and dementia. This study aimed to explore the relationship between preoperative EEG and POD. We included 257 patients aged >70 years who underwent spinal surgery. We measured the median dominant frequency (MDF), which is a resting-state EEG biomarker involving intrinsic alpha oscillations that reflect an idle cortical state, from the prefrontal regions...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37735216/comprehensive-geriatric-assessment-to-predict-adverse-events-in-elderly-patients-undergoing-posterior-lumbar-fusion-surgery
#11
JOURNAL ARTICLE
Peng Cui, Ting Liu, Zheng Wang, Shuaikang Wang, Peng Wang, Chao Kong, Shibao Lu
PURPOSE: Although comprehensive geriatric assessment (CGA) has been used widely, its impact on adverse events in elderly patients has not been fully examined. The present study aimed to investigate the relationships between subcomponents of CGA and adverse events (AEs) in elderly patients undergoing posterior lumbar fusion surgery. METHODS: A total of 242 eligible elderly patients enrolled. Our CGA included activities of daily living, instrumental activities of daily living, nutritional status, cardiac function, pulmonary function, renal function, frailty, cognition, anxiety, depression, delirium, chronic pain score, comorbidity and polypharmacy...
September 21, 2023: European Spine Journal
https://read.qxmd.com/read/37699863/construction-of-a-risk-prediction-model-for-detecting-postintensive-care-syndrome-mental-disorders
#12
JOURNAL ARTICLE
Faying Wang, Jingshu Li, Yuying Fan, Xiaona Qi
BACKGROUND: Postintensive care syndrome (PICS) has adverse multidimensional effects on nearly half of the patients discharged from ICU. Mental disorders such as anxiety, depression and post-traumatic stress disorder (PTSD) are the most common psychological problems for patients with PICS with harmful complications. However, developing prediction models for mental disorders in post-ICU patients is an understudied problem. AIMS: To explore the risk factors of PICS mental disorders, establish the prediction model and verify its prediction efficiency...
September 12, 2023: Nursing in Critical Care
https://read.qxmd.com/read/37691483/discharge-to-rehabilitation-oriented-care-after-acute-hospital-stay-association-with-vulnerability-screening-on-hospital-admission
#13
JOURNAL ARTICLE
Aafke J de Groot, Elisabeth M Wattel, Romke van Balen, Cees M P M Hertogh, Johannes C van der Wouden
BACKGROUND: We assessed the vulnerability of patients aged ≥ 70 years during hospital admission based on the Short Dutch Safety Management Screening (DSMS). Screening of four geriatric domains aims to prevent adverse outcomes and may support targeted discharge planning for post-acute care. We explored whether the DSMS criteria for acutely admitted patients were associated with rehabilitation-oriented care needs. METHODS: This retrospective cohort study included community-dwelling patients aged ≥ 70 years acutely admitted to a tertiary hospital...
September 11, 2023: Annals of geriatric medicine and research
https://read.qxmd.com/read/37663963/risk-factors-for-postoperative-delirium-in-elderly-patients-undergoing-gastroenterological-surgery-a-single-center-retrospective-study
#14
JOURNAL ARTICLE
Tomoyuki Sugi, Tsuyoshi Enomoto, Yusuke Ohara, Kinji Furuya, Daichi Kitaguchi, Shoko Moue, Yoshimasa Akashi, Koichi Ogawa, Yohei Owada, Tatsuya Oda
AIM: To investigate the risk factors for postoperative delirium among elderly patients undergoing elective surgery for gastroenterological cancer. METHODS: From May 2020 to March 2022, patients ≥75 years old with gastroenterological cancer who underwent radical surgery were enrolled. The geriatric assessment, including evaluations of frailty, physical function, nutrition status, and cognitive function, was conducted preoperatively. The confusion assessment method was used to diagnose postoperative delirium...
September 2023: Annals of Gastroenterological Surgery
https://read.qxmd.com/read/37580439/differences-in-medication-use-by-gender-and-race-in-hospitalized-persons-living-with-dementia
#15
JOURNAL ARTICLE
Barbara Resnick, Marie Boltz, Elizabeth Galik, Ashley Kuzmik, Rachel McPherson, Brittany Drazich, Nayeon Kim, Shijun Zhu, Chris L Wells
The purpose of this study was to describe differences in treatment of White versus Black older adults, males versus females, and those living at home, assisted living, or nursing home communities with regard to the use of psychotropic, pain, and cardiovascular medications. Baseline data from the first 352 participants in the study, implementation of Function-Focused Care for Acute Care Using the Evidence Integration Triangle, were used. Data included age, gender, race, comorbidities, admission diagnosis, and living location prior to hospitalization, the Saint Louis University Mental Status exam, the modified Charlson Comorbidity Index, the Pain Assessment in Advanced Dementia scale, the Confusion Assessment Method, and medications prescribed...
August 14, 2023: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/37566934/association-of-postoperative-delirium-and-parkinson-disease-after-common-united-states-surgical-procedures
#16
JOURNAL ARTICLE
Bhavpreet Dham, Irene Richard, Eric B Schneider, Benjamin P George
INTRODUCTION: To determine the association of Parkinson disease (PD) and postoperative delirium following common surgical procedures. METHODS: We performed a retrospective database analysis of the National Inpatient Sample. We used a matched sample of patients with and without PD who underwent any of ten common surgical procedures in the US, 2005-2014. Primary outcome measure was postoperative delirium for patients with and without PD. Secondary measures included disposition, length of stay, and hospital costs...
August 9, 2023: Journal of Surgical Research
https://read.qxmd.com/read/37529818/gender-disparities-in-hospitalization-outcomes-and-healthcare-utilization-among-patients-with-systemic-lupus-erythematosus-in-the-united-states
#17
JOURNAL ARTICLE
Fidelis Uwumiro, Victory O Okpujie, Osasumwen Osemwota, Nnenna E Okafor, Michael I Otu, Azabi Borowa, Pascal Ezerioha, Ejiroghene Tejere, Hillary Alemenzohu, Michael M Bojerenu
Background Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by various clinical manifestations. Despite efforts to improve outcomes, mortality rates remain high, and certain disparities, including gender, may influence prognosis and mortality rates in SLE. This study aims to examine the gender disparities in outcomes of SLE hospitalizations in the US. Methods We conducted a retrospective analysis of the Nationwide Inpatient Sample (NIS) database between 2016 and 2020. The NIS database is the largest publicly available all-payer database for inpatient care in the United States, representing approximately 20% of all hospitalizations nationwide...
July 2023: Curēus
https://read.qxmd.com/read/37263869/clinical-data-or-scoring-system-for-predicting-mortality-in-elderly-patients-with-hip-fracture-a-prospective-study
#18
JOURNAL ARTICLE
Ricardo Machado Castanheira de Souza, Renan Dias Frassei, Luiza de Campos Moreira da Silva, Miguel Antonio Rahal, Jorge Dos Santos Silva, Kodi Edson Kojima
INTRODUCTION: Hip fracture in elderly individuals is frequent and is related to a high rate of mortality. Finding the best predictor of death will help to develop better patient care. Aim - To analyze the reliability of the clinical data and assessment scores to predict mortality in acute hip fracture in elderly patients. PATIENT AND METHODS: Prospective data were collected from all patients > 65 years with acute hip fracture from May to October 2020. The clinical data collected were age, sex, comorbidities, medication, type of fracture and presence of delirium...
May 26, 2023: Injury
https://read.qxmd.com/read/36974254/implementation-of-orthogeriatrics-in-portugal
#19
JOURNAL ARTICLE
Pedro Magalhães, Mariana Gonçalves, Fátima Silva, Tiago Fernandes, Agripino Oliveira, Rafaela Veríssimo
INTRODUCTION: Orthogeriatrics is the subspecialty of geriatrics that is dedicated to the care of elderly patients with fragility fractures. The Orthogeriatrics Unit of the Vila Nova de Gaia Hospital Centre was the first unit created in Portugal in October 2015, in a co-management model. METHODS: Patients older than 65 years and with femur fractures were admitted to the unit after surgery. The department was run by internists with differentiation in geriatrics, and multidisciplinary support from orthopaedics, physiatrists, physiotherapists, nutritionists, and social workers, as well as rehabilitation nursing...
February 2023: Curēus
https://read.qxmd.com/read/36963165/anti-inflammatory-medication-use-associated-with-reduced-delirium-risk-and-all-cause-mortality-a-retrospective-cohort-study
#20
JOURNAL ARTICLE
Takehiko Yamanashi, Eleanor J Sullivan, Katie R Comp, Yoshitaka Nishizawa, Cade C Akers, Gloria Chang, Manisha Modukuri, Tammy Tran, Zoe-Ella E M Anderson, Pedro S Marra, Kaitlyn J Crutchley, Nadia E Wahba, Masaaki Iwata, Matthew D Karam, Nicolas O Noiseux, Hyunkeun R Cho, Gen Shinozaki
OBJECTIVE: To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality. METHODS: In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history including aspirin, NSAIDs, glucosamine, and other anti-inflammatory drugs, was collected. Logistic regression analysis investigated the relationship between anti-inflammatory medications and delirium...
May 2023: Journal of Psychosomatic Research
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